Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
MousePhenoincreased circulating prolactin level

LAMA2 NOS2 GABBR1

9.17e-068783MP:0005124
MousePhenoincreased prolactin level

LAMA2 NOS2 GABBR1

1.37e-059783MP:0005139
DomainIF5A_HYPUSINE

EIF5A2 EIF5A

7.82e-053962PS00302
DomainTransl_elong_IF5A_C

EIF5A2 EIF5A

7.82e-053962IPR020189
DomainTransl_elong_IF5A

EIF5A2 EIF5A

7.82e-053962IPR001884
DomaineIF-5a

EIF5A2 EIF5A

7.82e-053962PF01287
DomainTrans_elong_IF5A_hypusine_site

EIF5A2 EIF5A

7.82e-053962IPR019769
DomaineIF-5a

EIF5A2 EIF5A

7.82e-053962SM01376
DomainEPHD

KDM4C JADE2 KDM4A

1.89e-0422963PS51805
DomainATP_grasp_subdomain_2

CAD TTLL7 TTLL4

5.33e-0431963IPR013816
DomainR3H

YTHDC2 NFX1

9.19e-049962SM00393
DomainJmjN

KDM4C KDM4A

1.15e-0310962SM00545
DomainJmjN

KDM4C KDM4A

1.15e-0310962PF02375
DomainJMJN

KDM4C KDM4A

1.15e-0310962PS51183
DomainJmjN

KDM4C KDM4A

1.15e-0310962IPR003349
DomainKOW

EIF5A2 EIF5A

1.40e-0311962IPR005824
DomainR3H

YTHDC2 NFX1

1.40e-0311962PS51061
DomainKOW

EIF5A2 EIF5A

1.40e-0311962PF00467
DomainR3H

YTHDC2 NFX1

1.40e-0311962PF01424
Domain-

YTHDC2 NFX1

1.40e-03119623.30.1370.50
DomainR3H_dom

YTHDC2 NFX1

1.40e-0311962IPR001374
DomainTTL

TTLL7 TTLL4

1.97e-0313962PS51221
DomainTTL/TTLL_fam

TTLL7 TTLL4

1.97e-0313962IPR004344
DomainTTL

TTLL7 TTLL4

1.97e-0313962PF03133
DomainMAM_1

PTPRU PTPRK

2.99e-0316962PS00740
DomainTranslation_prot_SH3-like

EIF5A2 EIF5A

3.38e-0317962IPR008991
DomainMAM

PTPRU PTPRK

3.38e-0317962SM00137
DomainMAM

PTPRU PTPRK

3.79e-0318962PF00629
DomainRib_L2_dom2

EIF5A2 EIF5A

3.79e-0318962IPR014722
DomainATP_grasp_subdomain_1

CAD TTLL7

3.79e-0318962IPR013815
DomainMAM_dom

PTPRU PTPRK

3.79e-0318962IPR000998
Domain-

EIF5A2 EIF5A

3.79e-03189622.30.30.30
DomainMAM_2

PTPRU PTPRK

3.79e-0318962PS50060
DomainRhoGAP

SRGAP2 FAM13A ARHGAP31

4.00e-0362963SM00324
DomainRhoGAP

SRGAP2 FAM13A ARHGAP31

4.18e-0363963PF00620
DomainRhoGAP_dom

SRGAP2 FAM13A ARHGAP31

4.37e-0364963IPR000198
DomainRHOGAP

SRGAP2 FAM13A ARHGAP31

4.37e-0364963PS50238
Domain-

SRGAP2 FAM13A ARHGAP31

4.37e-03649631.10.555.10
DomainSH3

SORBS2 SRGAP2 ITSN2 MACF1 ARHGEF26

5.15e-03216965PS50002
DomainConA-like_dom

LAMA2 PTPRU RYR3 FAT2 PTPRK

5.46e-03219965IPR013320
DomainSH3_domain

SORBS2 SRGAP2 ITSN2 MACF1 ARHGEF26

5.56e-03220965IPR001452
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

SORBS2 VWF KDM4C JADE2 POLG FBXO11 SRGAP2 RYR3 JAK1 DGLUCY PTPRK DROSHA EIF4G1 MACF1 KDM4A EXOC1

6.93e-071285991635914814
Pubmed

N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.

SORBS2 VWF NUMA1 RPS20 SRGAP2 ANLN EIF4G1 MACF1 EXOC1

9.42e-0736099933111431
Pubmed

Glypican-6 stimulates intestinal elongation by simultaneously regulating Hedgehog and non-canonical Wnt signaling.

ROR2 GPC6 MKI67

4.83e-061299331756413
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

ERBB2 CAD ROR2 NUMA1 YTHDC2 TMEM214 EIF4G1 EIF5A MACF1 BOD1L1 ARHGEF26

5.73e-06708991139231216
Pubmed

A new subtype of brachydactyly type B caused by point mutations in the bone morphogenetic protein antagonist NOGGIN.

NOG ROR2

8.02e-06299217668388
Pubmed

Breast infiltrating ductal carcinoma: analysis of hormone, HER-2 receptors and Ki-67 proliferation marker.

ERBB2 MKI67

8.02e-06299218982746
Pubmed

Significance of HER2 and Ki-67 in Preneoplastic Lesions and Carcinoma of Gallbladder.

ERBB2 MKI67

8.02e-06299230155833
Pubmed

Correlations of β-catenin, Ki67 and Her-2/neu with gastric cancer.

ERBB2 MKI67

8.02e-06299224507671
Pubmed

Blocking triggering receptor expressed on myeloid cells-1 attenuates lipopolysaccharide-induced acute lung injury via inhibiting NLRP3 inflammasome activation.

NLRP3 TREM1

8.02e-06299228004759
Pubmed

[Expression discordances and clinical values of ER, PR, HER-2 and Ki-67 in primary and metastatic breast cancer].

ERBB2 MKI67

8.02e-06299231550858
Pubmed

[Relationship between expression of inducible nitric oxide synthase and proliferative potency of endothelium in hemangioma in infants].

MKI67 NOS2

8.02e-06299216573167
Pubmed

Expression of PFKFB3 and Ki67 in lung adenocarcinomas and targeting PFKFB3 as a therapeutic strategy.

PFKFB3 MKI67

8.02e-06299229327288
Pubmed

TREM-1 aggravates chronic obstructive pulmonary disease development via activation NLRP3 inflammasome-mediated pyroptosis.

NLRP3 TREM1

8.02e-06299234374795
Pubmed

Steroid receptors, HER2/neu and Ki-67, in endometrioid type of endometrial carcinoma: Correlation with conventional histomorphological features of prognosis.

ERBB2 MKI67

8.02e-06299219446313
Pubmed

Variability of predictive markers (hormone receptors, Her2, Ki67) and intrinsic subtypes of breast cancer in four consecutive years 2015-2018.

ERBB2 MKI67

8.02e-06299231628534
Pubmed

Expression and significance of Her2 and Ki-67 in gastric adenocarcinoma without distant metastasis: a cohort study.

ERBB2 MKI67

8.02e-06299233059614
Pubmed

Her2 and Ki67 Biomarkers Predict Recurrence of Ductal Carcinoma in Situ.

ERBB2 MKI67

8.02e-06299226317313
Pubmed

HER2/neu and Ki-67 expression predict non-invasive recurrence following breast-conserving therapy for ductal carcinoma in situ.

ERBB2 MKI67

8.02e-06299222361634
Pubmed

Importance of Ki-67 in human epidermal growth factor receptor 2 positive breast cancer.

ERBB2 MKI67

8.02e-06299226214624
Pubmed

Structural investigations of the nickel-induced inhibition of truncated constructs of the JMJD2 family of histone demethylases using X-ray absorption spectroscopy.

KDM4C KDM4A

8.02e-06299223692052
Pubmed

ANLN is a prognostic biomarker independent of Ki-67 and essential for cell cycle progression in primary breast cancer.

ANLN MKI67

8.02e-06299227863473
Pubmed

Assessment of the predictive role of pretreatment Ki-67 and Ki-67 changes in breast cancer patients receiving neoadjuvant chemotherapy according to the molecular classification: a retrospective study of 1010 patients.

ERBB2 MKI67

8.02e-06299229480449
Pubmed

A High-Density Map for Navigating the Human Polycomb Complexome.

SFMBT1 CHAF1A FBXO11 MSL1 KANSL3 YAF2 EIF4G1 PAXIP1 BOD1L1

1.24e-0549599927705803
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ERBB2 SPEG POLG TMC6 SRGAP2 KANSL3 PLEKHM2 TTLL4 EIF4G1 NFX1 PAXIP1 ADAT1 GAREM1

1.55e-051105991335748872
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

ZHX3 CHAF1A NUMA1 EIF5A2 RPS20 MSL1 NOSIP ANLN EIF4G1 EIF5A MKI67 BOD1L1

1.75e-05954991236373674
Pubmed

Glypican-6 and Glypican-4 stimulate embryonic stomach growth by regulating Hedgehog and noncanonical Wnt signaling.

ROR2 GPC6 MKI67

1.77e-051899336057966
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

CASP8AP2 RELCH ERBB2 JADE2 KANSL3 ARHGAP31 AMOT TTLL4 KDM4A

2.10e-0552999914621295
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

CAD CHAF1A FBXO11 YTHDC2 MSL1 TMEM214 SRGAP2 LRCH3 ANLN DROSHA ITSN2 EIF4G1 NFX1 GATAD1 MACF1

2.16e-051497991531527615
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ZHX3 SORBS2 SPEG PLEKHM2 ITSN2 MACF1 BOD1L1 PCDH10

2.22e-0540799812693553
Pubmed

Expression of p53, c-erbB-2 and Ki67 in intestinal metaplasia and gastric carcinoma.

ERBB2 MKI67

2.40e-05399220082479
Pubmed

Lipin-2 regulates NLRP3 inflammasome by affecting P2X7 receptor activation.

NLRP3 LPIN2

2.40e-05399228031477
Pubmed

Immunoexpression of PTEN, HER2/neu, and Ki-67 in endoscopic gastric carcinoma biopsies; their correlation with histological subtypes and one-year survival.

ERBB2 MKI67

2.40e-05399235074962
Pubmed

Cutting edge: nitric oxide inhibits the NLRP3 inflammasome.

NLRP3 NOS2

2.40e-05399223100513
Pubmed

Human eIF5A2 on chromosome 3q25-q27 is a phylogenetically conserved vertebrate variant of eukaryotic translation initiation factor 5A with tissue-specific expression.

EIF5A2 EIF5A

2.40e-05399211161802
Pubmed

MicroRNA-9 Inhibits NLRP3 Inflammasome Activation in Human Atherosclerosis Inflammation Cell Models through the JAK1/STAT Signaling Pathway.

NLRP3 JAK1

2.40e-05399228334721
Pubmed

Neutrophil NLRP3 promotes cardiac injury following acute myocardial infarction through IL-1β production, VWF release and NET deposition in the myocardium.

VWF NLRP3

2.40e-05399238914598
Pubmed

Progesterone receptor status and Ki-67 index may predict early relapse in luminal B/HER2 negative breast cancer patients: a retrospective study.

ERBB2 MKI67

2.40e-05399225170613
Pubmed

NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins.

MBD3L1 CHAF1A

2.40e-05399229533181
Pubmed

Comparative integromics on JMJD2A, JMJD2B and JMJD2C: preferential expression of JMJD2C in undifferentiated ES cells.

KDM4C KDM4A

2.40e-05399217611647
Pubmed

Transforming growth factor {beta} (TGF-{beta})-Smad target gene protein tyrosine phosphatase receptor type kappa is required for TGF-{beta} function.

ERBB2 PTPRK

2.40e-05399215899872
Pubmed

Identification and characterization of eukaryotic initiation factor 5A-2.

EIF5A2 EIF5A

2.40e-05399214622290
Pubmed

Evaluation of changes in biologic markers ER, PR, HER 2 and Ki-67 index in breast cancer with administration of neoadjuvant dose dense doxorubicin, cyclophosphamide followed by paclitaxel chemotherapy.

ERBB2 MKI67

2.40e-05399223818347
Pubmed

The role of ThinPrep cytology in the investigation of ki-67 index, p53 and HER-2 detection in fine-needle aspirates of breast tumors.

ERBB2 MKI67

2.40e-05399223818345
Pubmed

[Expressions and significances of EGFR, C-erbB2 and Ki-67 in nasal squamous cell carcinomas].

ERBB2 MKI67

2.40e-05399217674766
Pubmed

Expression of pRb, Ki67 and HER 2/neu in gastric carcinomas: Relation to different histopathological grades and stages.

ERBB2 MKI67

2.40e-05399228965621
Pubmed

Association between androgen receptor expression, Ki-67 and the 21-gene recurrence score in non-metastatic, lymph node-negative, estrogen receptor-positive and HER2-negative breast cancer.

ERBB2 MKI67

2.40e-05399226076967
Pubmed

[Abnormal expression of p53, Ki67 and iNOS in human esophageal carcinoma in situ and pre-malignant lesions].

MKI67 NOS2

2.40e-05399211783017
Pubmed

[Correlation of CerbB-2 to Ki-67 and P53 expressions in hormone-independent breast cancer].

ERBB2 MKI67

2.40e-05399221354936
Pubmed

Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development.

KDM4C KDM4A

2.40e-05399227266524
Pubmed

Ki-67 is a prognostic marker for hormone receptor positive tumors.

ERBB2 MKI67

2.40e-05399226742937
Pubmed

[Expression of HER2/neu in meningiomas: an immunohistochemistry and fluorescence in situ hybridization study].

ERBB2 MKI67

2.40e-05399220450760
Pubmed

The histone demethylase JMJD2C is stage-specifically expressed in preimplantation mouse embryos and is required for embryonic development.

KDM4C KDM4A

2.40e-05399219696013
Pubmed

New K50R mutant mouse models reveal impaired hypusination of eif5a2 with alterations in cell metabolite landscape.

EIF5A2 EIF5A

2.40e-05399236848144
Pubmed

Potential i-Nos/Arg-1 Switch with NLRP3 and Parasitic Load Down Regulation in Experimental Schistosoma mansoni Infection via Chloroquine Repurposing.

NLRP3 NOS2

2.40e-05399238498004
Pubmed

Differential expression of eIF5A-1 and eIF5A-2 in human cancer cells.

EIF5A2 EIF5A

2.40e-05399216519677
Pubmed

ESR1, ERBB2, and Ki67 mRNA expression predicts stage and grade of non-muscle-invasive bladder carcinoma (NMIBC).

ERBB2 MKI67

2.40e-05399227514658
Pubmed

Neoadjuvant chemotherapy-induced changes in immunohistochemical expression of estrogen receptor, progesterone receptor, HER2, and Ki-67 in patients with breast cancer.

ERBB2 MKI67

2.40e-05399225778295
Pubmed

Diversity within the JMJD2 histone demethylase family.

KDM4C KDM4A

2.40e-05399217207460
Pubmed

The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance.

KDM4C KDM4A

2.40e-05399231434704
Pubmed

P16, c-erbB2 and Ki67 immunoexpression in urothelial carcinomas of the bladder.

ERBB2 MKI67

2.40e-05399221655657
Pubmed

Prognostic molecular markers in women aged 35 years or younger with breast cancer: is there a difference from the older patients?

ERBB2 MKI67

2.40e-05399221642658
Pubmed

Role of WT1, B-cell lymphoma 2, Ki-67 (Mib1), and Her2/Neu as diagnostic and prognostic immunomarkers in ovarian serous and endometroid carcinoma.

ERBB2 MKI67

2.40e-05399233723149
Pubmed

Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.

PTPRK MKI67 AIFM3 MACF1 GABBR1

3.38e-0512899530995482
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

PABIR1 ERBB2 SORBS2 ROR2 SRGAP2 FAM13A ANLN AMOT EIF4G1 MACF1 BOD1L1

3.49e-05861991136931259
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

YTHDC2 SRGAP2 NOSIP AMOT EIF4G1 NFX1 EIF5A MKI67 MACF1 EXOC1

4.23e-05724991036232890
Pubmed

Histone demethylase KDM4C controls tumorigenesis of glioblastoma by epigenetically regulating p53 and c-Myc.

KDM4C KDM4A

4.79e-05499233462212
Pubmed

Analysis of c-ErbB1/epidermal growth factor receptor and c-ErbB2/HER-2 expression in bronchial dysplasia: evaluation of potential targets for chemoprevention of lung cancer.

ERBB2 MKI67

4.79e-05499216609045
Pubmed

Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer.

ERBB2 MKI67

4.79e-05499219436038
Pubmed

An international reproducibility study validating quantitative determination of ERBB2, ESR1, PGR, and MKI67 mRNA in breast cancer using MammaTyper®.

ERBB2 MKI67

4.79e-05499228490348
Pubmed

Differential expression of MAM-subfamily protein tyrosine phosphatases during mouse development.

PTPRU PTPRK

4.79e-0549929510027
Pubmed

Expression of eukaryotic initiation factor 5A and hypusine forming enzymes in glioblastoma patient samples: implications for new targeted therapies.

EIF5A2 EIF5A

4.79e-05499222927971
Pubmed

Prognostic significance of estrogen receptor, progesterone receptor, HER2/neu, Ki-67, and nm23 expression in patients with invasive breast cancer.

ERBB2 MKI67

4.79e-05499223818346
Pubmed

DHPS-dependent hypusination of eIF5A1/2 is necessary for TGFβ/fibronectin-induced breast cancer metastasis and associates with prognostically unfavorable genomic alterations in TP53.

EIF5A2 EIF5A

4.79e-05499231558321
Pubmed

Histone Demethylases KDM4A and KDM4C Regulate Differentiation of Embryonic Stem Cells to Endothelial Cells.

KDM4C KDM4A

4.79e-05499226120059
Pubmed

Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells.

KDM4C KDM4A

4.79e-05499227257215
Pubmed

The post-translational synthesis of a polyamine-derived amino acid, hypusine, in the eukaryotic translation initiation factor 5A (eIF5A).

EIF5A2 EIF5A

4.79e-05499216452303
Pubmed

Clinicopathological significance of androgen receptor, HER2, Ki-67 and EGFR expressions in salivary duct carcinoma.

ERBB2 MKI67

4.79e-05499224553861
Pubmed

The histone demethylase Kdm4 suppresses activation of hepatic stellate cell by inducing MiR-29 transcription.

KDM4C KDM4A

4.79e-05499231014673
Pubmed

Useful immunohistochemical markers for distinguishing Paget cells from Toker cells.

ERBB2 MKI67

4.79e-05499220001343
Pubmed

THE STUDY OF THE EXPRESSION OF CDH1, KI67, P53 AND HER2 IN DIFFUSE GASTRIC CARCINOMA.

ERBB2 MKI67

4.79e-05499232242863
Pubmed

Development of circulating tumor cell-endocrine therapy index in patients with hormone receptor-positive breast cancer.

ERBB2 MKI67

4.79e-05499225381338
Pubmed

Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

MARK1 SPEG RPS20 GPC6 MACF1 GABBR1

5.39e-0523199616452087
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

CAD SORBS2 VWF MARK1 EIF5A2 YTHDC2 RPS20 SRGAP2 LRCH3 AMOT ITSN2 EIF4G1 MACF1 EXOC1

5.40e-051431991437142655
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

ZHX3 CHAF1A NUMA1 MSL1 ANLN MKI67 GATAD1 BOD1L1 KDM4A

6.16e-0560899936089195
Pubmed

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.

KDM4C JADE2 PTPRK EIF4G1 KDM4A

6.98e-0514999525231870
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

ZHX3 SORBS2 CHAF1A NUMA1 YTHDC2 KANSL3 FAM13A ANLN EIF4G1 MKI67

7.37e-05774991015302935
Pubmed

A human MAP kinase interactome.

CASP8AP2 VWF JADE2 CHAF1A ARHGAP31 ITSN2 MACF1 GAREM1

7.73e-0548699820936779
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

SFMBT1 CASP8AP2 CHAF1A NUMA1 FBXO11 RPS20 MSL1 TMEM214 KANSL3 YAF2 PAXIP1 MKI67 GATAD1

7.83e-051294991330804502
Pubmed

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

CASP8AP2 SPEG KANSL3 BOD1L1 PCDH10

7.91e-0515399510718198
Pubmed

Mitochondrial DNA alterations correlate with the pathological status and the immunological ER, PR, HER-2/neu, p53 and Ki-67 expression in breast invasive ductal carcinoma.

ERBB2 MKI67

7.98e-05599225845386
Pubmed

Biological Relevance and Therapeutic Potential of the Hypusine Modification System.

EIF5A2 EIF5A

7.98e-05599226037925
Pubmed

TREM-1 induces pyroptosis in cardiomyocytes by activating NLRP3 inflammasome through the SMC4/NEMO pathway.

NLRP3 TREM1

7.98e-05599236181338
Pubmed

Evaluation of IL-1 Blockade as an Adjunct to Linezolid Therapy for Tuberculosis in Mice and Macaques.

NLRP3 NOS2

7.98e-05599232477361
Pubmed

Non-small cell lung carcinoma: cyclin D1, bcl-2, p53, Ki-67 and HER-2 proteins expression in resected tumors.

ERBB2 MKI67

7.98e-05599217848143
Pubmed

Tissue-specific expression of the human laminin alpha5-chain, and mapping of the gene to human chromosome 20q13.2-13.3 and to distal mouse chromosome 2 near the locus for the ragged (Ra) mutation.

LAMA2 SOX18

7.98e-0559929271224
Pubmed

Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family.

KDM4C KDM4A

7.98e-05599221914792
Pubmed

Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells.

KDM4C KDM4A

7.98e-05599216738407
Pubmed

Cloning of a novel murine gene Sfmbt, Scm-related gene containing four mbt domains, structurally belonging to the Polycomb group of genes.

SFMBT1 CHAT

7.98e-05599210806358
Pubmed

Calcitonin Receptor Signaling Inhibits Muscle Stem Cells from Escaping the Quiescent State and the Niche.

LAMA2 MKI67

7.98e-05599226440893
Pubmed

Brucella abortus nitric oxide metabolite regulates inflammasome activation and IL-1β secretion in murine macrophages.

NLRP3 NOS2

7.98e-05599230919410
InteractionYWHAQ interactions

PABIR1 CAD SORBS2 MARK1 SPEG CHAF1A ROR2 NUMA1 CHAT SRGAP2 PFKFB3 YAF2 FAM13A ANLN EIF4G1 NFX1 MACF1 NOS2 GAREM1

8.02e-0711189419int:YWHAQ
InteractionYWHAZ interactions

PABIR1 ERBB2 CAD SORBS2 MARK1 SPEG CHAF1A ROR2 SRGAP2 PFKFB3 YAF2 FAM13A ANLN LPIN2 NFX1 MACF1 MAP3K15 NOS2 GABBR1 GAREM1

2.30e-0613199420int:YWHAZ
InteractionYWHAG interactions

PABIR1 CAD SORBS2 MARK1 SPEG CHAF1A ROR2 SRGAP2 PFKFB3 LRCH3 TTLL7 FAM13A ANLN AMOT EIF4G1 MACF1 BOD1L1 NOS2 GAREM1

4.07e-0612489419int:YWHAG
InteractionEIF3H interactions

SORBS2 CHAF1A NUMA1 RPS20 ANLN EIF4G1 NFX1 PAXIP1 MKI67

6.81e-06282949int:EIF3H
InteractionYWHAE interactions

PABIR1 CAD SORBS2 MARK1 CHAF1A SRGAP2 LRCH3 TTLL7 JAK1 YAF2 FAM13A ANLN LPIN2 NFX1 MACF1 MAP3K15 NOS2 GAREM1

1.74e-0512569418int:YWHAE
InteractionYWHAH interactions

PABIR1 SORBS2 MARK1 SPEG ROR2 SRGAP2 PFKFB3 TTLL7 YAF2 FAM13A ANLN AMOT EIF4G1 MACF1 BOD1L1 MAP3K15

4.67e-0511029416int:YWHAH
GeneFamilyRho GTPase activating proteins|BCH domain containing

SRGAP2 FAM13A ARHGAP31

8.42e-0450673721
GeneFamilyTubulin tyrosine ligase family

TTLL7 TTLL4

1.20e-0314672779
CoexpressionGSE7509_UNSTIM_VS_FCGRIIB_STIM_MONOCYTE_DN

VWF POLG SRGAP2 TTLL4 PAXIP1 MACF1 BOD1L1 DISP1

2.29e-07166998M6826
CoexpressionCUI_TCF21_TARGETS_2_DN

SFMBT1 KDM4C MARK1 SPEG PFKFB3 ATP10A TTLL7 JAK1 DENND6A ARHGAP31 ITSN2 LPIN2 MACF1 ARHGEF26

3.98e-068549914M1533
CoexpressionCUI_TCF21_TARGETS_2_DN

SFMBT1 KDM4C MARK1 SPEG PFKFB3 ATP10A TTLL7 JAK1 DENND6A ARHGAP31 ITSN2 LPIN2 MACF1 ARHGEF26

6.22e-068889914MM1018
ToppCell-Unknown-Endothelial-Myofibroblast| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RELCH ROR2 GPC6 ARHGAP31 TTLL4 ARNT2 PAXIP1

2.14e-071889976468fa95ad0395395301115286f2d8c0df5d3882
ToppCell-Unknown-Endothelial| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RELCH ROR2 GPC6 ARHGAP31 TTLL4 ARNT2 PAXIP1

2.14e-071889977a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell-Unknown| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RELCH ROR2 GPC6 ARHGAP31 TTLL4 ARNT2 PAXIP1

2.14e-071889979cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCellLA-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

GPC6 ATP10A RYR3 TTLL7 MACF1 ARHGEF26

4.11e-061899966b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCellfacs-Skin-Anagen-3m-Epithelial-bulge_keratinocyte|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SORBS2 NOG GPC6 TTLL7 PTPRK MACF1

4.64e-06193996eba3c70701b051bc1ed1f4db9270cb27a77ffc3e
ToppCellfacs-Skin-Anagen-3m-Epithelial-outer_bulge|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SORBS2 NOG GPC6 TTLL7 PTPRK MACF1

4.78e-061949965d30d3d41d5f19cdf3077cc609aa2738762cb8c5
ToppCellBAL-Mild-Myeloid-MoAM-MoAM2|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SRGAP2 PFKFB3 NLRP3 ARNT2 GABBR1

2.35e-051539955fbb90b8477f9fdabf3be19efd3068fbf70abee6
ToppCellChildren_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

MARK1 SPEG LAMA2 FAT2 PCDH10

2.35e-051539951524557514668f515ac1bbe847611f564b265b42
ToppCellBAL-Mild-Myeloid-MoAM-MoAM2-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SRGAP2 PFKFB3 NLRP3 ARNT2 GABBR1

2.35e-051539952c46183481e6d5a7fa190a743062509465f88e56
ToppCellBAL-Mild-Myeloid-MoAM-MoAM2|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

SRGAP2 PFKFB3 NLRP3 ARNT2 GABBR1

2.35e-05153995decc4f3098a9374a6b65c015a9d36380986290bf
ToppCellBAL-Mild-Myeloid-MoAM-MoAM2-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SRGAP2 PFKFB3 NLRP3 ARNT2 GABBR1

2.35e-0515399536a28805c0545c2f410c74a6ca0a70d840e75715
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

VWF SOX18 RYR3 ZNF469 ARHGAP31

3.10e-05162995c399b9e4854916a59f5cae2d8dbf19660f8759be
ToppCellMild_COVID-19-Myeloid-MoAM2|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）

SRGAP2 PFKFB3 NLRP3 ARNT2 GABBR1

3.10e-05162995e5fc80ab19d513af6a7e677a5e67bfebca2e963b
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

VWF SOX18 RYR3 ZNF469 ARHGAP31

3.10e-05162995a291248b693c771845174393934a782f1d8bd7ce
ToppCellFetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MARK1 SPEG NMUR2 ATP10A TTLL7

3.19e-0516399551dee6c21cbeca4e17d1cc386e203f0c403089e8
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOG VWF SOX18 PTPRU ARHGAP31

3.68e-051689953bddf411a60137a8883fc9e77586e4719b0d6067
ToppCellAdult-Endothelial-endothelial_cell_of_artery-D122|Adult / Lineage, Cell type, age group and donor

VWF SPEG SOX18 RYR3 PCDH10

3.68e-051689958c3e1e45b422813bcdfa4273b1167db649a312f5
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOG VWF SOX18 PTPRU ARHGAP31

3.68e-05168995b6d948857ee652351ddbe383b75fdd1721cd8721
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CASP8AP2 RYR3 DENND6A MACF1 ADAT1

3.79e-0516999516c52a0f6d96ecc1832922fce9b39691849f0d73
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SORBS2 NOG SPEG ROR2 RYR3

4.01e-0517199582de2885c8ce4fb7776da6a0207b3355c0910121
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SORBS2 NOG SPEG ROR2 RYR3

4.01e-0517199509e653973962fb884878089d281f0947f7a285f6
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SRGAP2 GPC6 ATP10A RYR3 ARHGEF26

4.12e-05172995381ae1c3c07d0a424f43455ec571653b192a946a
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SRGAP2 GPC6 ATP10A RYR3 ARHGEF26

4.35e-05174995dbdcdec08f1fc69fcdb5d8a6d78df8ef9c374d89
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZHX3 ROR2 LAMA2 MACF1 ARHGEF26

4.47e-051759951799a7be623dc3bf53ba580a7c47d2619969d708
ToppCellCOVID-19-kidney-Podocyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

SRGAP2 GPC6 ATP10A RYR3 ARHGEF26

4.47e-05175995a73e3a65fd5c1e09cb0c2dae20c1a7bfcae49223
ToppCellChildren_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

MARK1 SPEG ROR2 LAMA2 PCDH10

4.72e-05177995b59967219f7d874805768e247c0eb2bc4d4420c8
ToppCellfacs-Lung-18m-Endothelial-venous_endothelial-vein_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SORBS2 VWF SOX18 PTPRU ARHGAP31

4.85e-05178995ebfae386a518ea33911ba3ff40464c94d18ef695
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PABIR1 ZHX3 ANLN MACF1 TRMT12

4.85e-05178995c87945146b2734141f07b39d268e0d8086ee0364
ToppCellfacs-Lung-18m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SORBS2 VWF SOX18 PTPRU ARHGAP31

4.85e-05178995ccd37575b60102f5e647c01546e8ff8fec638bd7
ToppCellfacs-Lung-18m-Endothelial-venous_endothelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SORBS2 VWF SOX18 PTPRU ARHGAP31

4.85e-0517899587b04753650e45f12299c8456fb980d6c0d5961c
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Colon_Adenocarcinoma-10|TCGA-Colorectal / Sample_Type by Project: Shred V9

RASGRP4 ATP10A NLRP3 ZNF469 ARHGAP31

4.98e-05179995cc079ba015326dccde955c5eafa3e4a2e40de192
ToppCellASK454-Epithelial-Ciliated|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

SFMBT1 PRMT8 SNTN TTLL7 AMOT

4.98e-05179995f21919ef9d3d984e2925ef3d24f89e20fe265dcd
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SRGAP2 GPC6 ATP10A RYR3 ARHGEF26

5.25e-051819955bf7aa43f6e6ecce15c95928b91195544d6928c4
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SRGAP2 GPC6 ATP10A RYR3 ARHGEF26

5.25e-051819958e751f5d7cd2d328ec0196d874e8a507e8c4e1a9
ToppCelldroplet-Marrow-nan-3m-Hematologic-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CASP8AP2 JAK1 ITSN2 MACF1 BOD1L1

5.39e-05182995e78ba2c5cae480c16a596ce7c3bf2d480becacf4
ToppCelldroplet-Marrow-nan-3m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CASP8AP2 JAK1 ITSN2 MACF1 BOD1L1

5.39e-051829951710eab3037a87609d21838be2d2d29c3bc36651
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SORBS2 VWF SOX18 SNTN TTLL7

5.53e-051839956f8f997ffc9eaebca2683de125b6069d07c07d26
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

VWF SOX18 ZNF469 ARHGAP31 NOS2

5.53e-05183995dc19857b66dcadbf7c87de91f7b1f4e8ef2857ed
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

VWF SOX18 ZNF469 ARHGAP31 NOS2

5.53e-051839954759560e5b4f4e5a00e5f933e3451a27c7c4aefe
ToppCelldroplet-Lung-LUNG-30m-Myeloid-Proliferating_Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHAF1A ATP10A TC2N ANLN MKI67

5.68e-0518499516aa8e88bdd51b1d132d5cf33c29963b384a8bae
ToppCellAdult-Endothelial-endothelial_cell_of_artery|Adult / Lineage, Cell type, age group and donor

VWF SOX18 RYR3 ARNT2 PCDH10

5.98e-051869952d1c4ea2e401db89971582ee54618a8b0c81b8ac
ToppCelldroplet-Lung-3m-Endothelial-venous_endothelial-vein_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SORBS2 VWF SOX18 PTPRU ARHGAP31

6.13e-051879953827fa80e558b642f3e0036f5ee1a8b69f437e30
ToppCelldroplet-Lung-3m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SORBS2 VWF SOX18 PTPRU ARHGAP31

6.13e-051879951bf696eb03422ea507d3efe58dda1d442a65225d
ToppCelldroplet-Lung-3m-Endothelial-venous_endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SORBS2 VWF SOX18 PTPRU ARHGAP31

6.13e-05187995ebe4d1216cc0d4c079b413d5a5460cfd3a4af922
ToppCellCOVID-19-Fibroblasts-Airway_smooth_muscle|COVID-19 / group, cell type (main and fine annotations)

SPEG ROR2 LAMA2 GPC6 TTLL7

6.13e-05187995464a0c3b92b778911b5f9cd73642e09e3472063a
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SORBS2 GPC6 TTLL7 PTPRK LPIN2

6.44e-051899953b48b0d220cc24d5170713d61fa91f5bb6c21841
ToppCellControl-Endothelial-VE_Capillary_B|Endothelial / Disease state, Lineage and Cell class

SORBS2 VWF LAMA2 SRGAP2 PTPRK

6.61e-051909957f3f419fffe02934b6f27b697f7a6401072491ed
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SPEG ROR2 LAMA2 GPC6 TTLL7

6.61e-05190995562ee3b025c29edf07b8b344323edb49d82f1c7e
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SPEG ROR2 LAMA2 GPC6 TTLL7

6.61e-05190995f5fb989afabb49d64d91324570cd8c80a4b9e67d
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ROR2 LAMA2 GPC6 ATP10A ARHGEF26

6.61e-051909950fea33f2dc1efa23aaa2da1c318482a52a313ff1
ToppCellASK454-Epithelial-Ciliated|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

SFMBT1 CAD SNTN NOSIP AMOT

6.61e-051909955cea6480f08253d7adf484e511d3fdfa96641268
ToppCellLPS_only-Endothelial-Endothelial-Activated_Alv_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VWF VPS4A PTPRK ARHGAP31 DISP1

6.77e-05191995a7b18bcf27c38ad2353c239ecb309c80f3ef3359
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ERBB2 MXRA5 ROR2 PFKFB3 TC2N

7.11e-05193995371f4c98a599923fbe8382530b3eab05d873665a
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

RELCH KDM4C LRCH3 TC2N MACF1

7.11e-051939959337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ERBB2 MXRA5 ROR2 PFKFB3 MAP3K15

7.29e-05194995d602a0cdb69cd5a3e9ef61ddbab8d920557dd73e
ToppCelldroplet-Lung-nan-18m-Endothelial-Capillary_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF SOX18 PTPRU ARHGAP31 ARHGEF26

7.29e-05194995faaa7f18667e8943528fd0e92b7988e5b0607b54
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPEG LAMA2 GPC6 ATP10A TTLL7

7.29e-05194995ebb038f94f49f5c655578d1b018676e10c6b7e3c
ToppCellCOVID-19_Mild-Lymphoid_T/NK-CD4+_T_naive|COVID-19_Mild / Disease group, lineage and cell class

NOG RPS20 NOSIP TC2N FAM13A

7.47e-051959958aec807b24bcebf1a8011d676d2143b6fc570f1d
ToppCellCOVID_non-vent-Lymphocytic-T_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

JADE2 NOSIP TC2N LPIN2 MACF1

7.47e-051959954bdedd924564a260841a9153604026b57487c83d
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_naive-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NOG RPS20 NOSIP TC2N FAM13A

7.47e-05195995d9965223430aba1ec0b1b77b5bd40d3a01e42e95
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_naive-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

NOG RPS20 NOSIP TC2N FAM13A

7.47e-05195995d056c806c7ad38ca425bdaa44385424a7f43f915
ToppCellCOVID-19_Moderate-CD4+_T_naive|World / disease group, cell group and cell class

NOG RPS20 NOSIP TC2N FAM13A

7.47e-0519599538d65cf0895f7a99d789ec3dcbd56a7506706d38
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_naive|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NOG RPS20 NOSIP TC2N FAM13A

7.47e-051959951d3c51a3be5ad1fbc465c5f684565ec4c6f35f54
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_naive|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

NOG RPS20 NOSIP TC2N FAM13A

7.47e-051959956421d949bfebcd985bea7efc5731a1ca79350b61
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPEG LAMA2 GPC6 ATP10A TTLL7

7.65e-051969951522958a92e0126326a9f0d9fb1c5b5c50b001ea
ToppCellCOVID-19-lung-Proliferative_fibroblast|lung / Disease (COVID-19 only), tissue and cell type

ROR2 LAMA2 GPC6 ANLN MKI67

7.65e-051969952ce8a787f2731faa913d20342d73041d59468f27
ToppCellFibroblasts-DKK3+_Fibroblasts|Fibroblasts / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

MXRA5 NOG LAMA2 ATP10A PTPRK

7.65e-0519699524d64b67aa9b0e8215ad06f9101c1314b3483620
ToppCellCOPD-Multiplet-Multiplet|COPD / Disease state, Lineage and Cell class

SORBS2 SNTN PTPRK MKI67 MACF1

7.65e-05196995af4cdc61830685a888a1209826c23bcf54a43084
ToppCellCOVID-19_Moderate-CD4+_T_naive|COVID-19_Moderate / disease group, cell group and cell class

NOG RPS20 NOSIP TC2N FAM13A

7.65e-05196995b1a463cf4cf3755086f3420b8892d493af8cacbe
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPEG LAMA2 GPC6 ATP10A TTLL7

7.65e-051969951c8294014713684b50885e638668f2ce75f357f0
ToppCellCOPD-Multiplet|COPD / Disease state, Lineage and Cell class

SORBS2 SNTN PTPRK MKI67 MACF1

7.65e-051969956d02d494196e3f857d53eea46d9419690d43beca
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SORBS2 SPEG GPC6 ATP10A TTLL7

7.84e-05197995aafe279b14cdcb786bc45524bc3c26261128ee48
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SORBS2 SPEG GPC6 ATP10A TTLL7

7.84e-05197995fb14da600f563273059a4683a5079af81aca0886
ToppCellCOVID_vent-Lymphocytic-T_cell|COVID_vent / Disease condition, Lineage, Cell class and subclass

JADE2 RPS20 NOSIP TC2N MACF1

7.84e-05197995ad702e440a74d54cfdcb8bb1c66bd8e0e71ab04e
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ERBB2 PTPRU GPC6 LPIN2 ARHGEF26

8.03e-05198995b598ab958e31f1e98bd06dc0097b58ac3a3f90a3
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_1|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ERBB2 PTPRU GPC6 LPIN2 ARHGEF26

8.22e-05199995a270630626df614f8605abddb7dee7c4d74f6149
ToppCellHematolymphoid-Endothelial-NOSTRIN|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

VWF LAMA2 ATP10A PTPRK ARNT2

8.41e-05200995032df80aa5c40991e1c1e80f9d8da106e6aeaee2
ToppCellHematolymphoid-Endothelial-NOSTRIN---|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

VWF LAMA2 ATP10A PTPRK ARNT2

8.41e-0520099568fce28690246895fd33354b30960ebcc31aa4cc
ToppCellHematolymphoid-Endothelial-NOSTRIN-|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

VWF LAMA2 ATP10A PTPRK ARNT2

8.41e-05200995376b19ab5a7cd2c85f726d8ba41337d4525863e5
ToppCellHematolymphoid-Endothelial-NOSTRIN--|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

VWF LAMA2 ATP10A PTPRK ARNT2

8.41e-052009957fa54370221ed61bac0e09e6bcf1f3dff202a846
ToppCellParenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_alveolar-Macro_alv_MT|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

RASGRP4 NLRP3 TREM1 AIFM3 EXOC1

8.41e-05200995f11ae9055e72c938b6c9e52701478b2eee681ac4
ToppCelldroplet-Skin-nan-21m-Epithelial-keratinocyte_stem_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOG CHAT GPC6 FAM13A PTPRK

8.41e-0520099569295705fc614c2687f2b6c8e6aa0c6717841008
ToppCellHematolymphoid-Endothelial-NOSTRIN----L2-6|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

VWF LAMA2 ATP10A PTPRK ARNT2

8.41e-05200995878bbbe32e3602723aa14ef32877ab2453b8c6e5
ToppCellHematolymphoid-Endothelial|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

VWF LAMA2 ATP10A PTPRK ARNT2

8.41e-052009957136936d05ab344a560cf159684c881063b5430d
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-CD4+_T_naive|COVID-19_Mild / Disease, condition lineage and cell class

NOG RPS20 NOSIP TC2N FAM13A

8.41e-05200995a51b61afc3fd2e548489901a86fb9d1c5bd3f95f
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_STALK|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

VWF SOX18 ATP10A NOS2

2.09e-04131994308ddb7fe113eac5dbeb9cb0b688d9e09275ce5e
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CASP8AP2 VWF NMUR2 ARHGAP31

2.62e-04139994b07929348ec9ad95d7bce33a7deac0938227b19f
ToppCellTCGA-Thymus-Primary_Tumor-Thymoma-Type_B1-4|TCGA-Thymus / Sample_Type by Project: Shred V9

POLG NMUR2 TRBV16 PAXIP1

2.69e-0414099421e5f55a98b819d3638ec971d5029b2fcbd1ebc7
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_low-phase|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SPEG PTPRU ANLN MKI67

2.99e-04144994f6061dd965a2b2fe6ad864f8aecc06d2e74881ce
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MXRA5 ROR2 PFKFB3 GAREM1

3.07e-04145994fd02d55755c35288a42ab08a82450b370aad35a7
ToppCellAT1-AT2_cells-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

PTPRU GPC6 TTLL7 ARHGEF26

3.07e-04145994cd5de30fd948024e3ad043c9411ce9f2722178b2
ToppCelldroplet-Pancreas-Exocrine-18m-Epithelial-pancreatic_acinar_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERBB2 POLG TC2N AIFM3

3.41e-04149994defe2e4a2f3118f8b42e99a4f2bf03e54c1b698f
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MXRA5 MARK1 ROR2 AMOT

3.58e-041519943744e4ed87703a97002e001afd16490d525a5128
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SPEG GPC6 ATP10A TTLL7

3.67e-04152994bd1f36b436d8ab7dd8420f595b97d851eab31a38
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SPEG GPC6 ATP10A TTLL7

3.67e-04152994ee329249a034a969a16b26a224aa04249d67382d
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_STALK|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

VWF SOX18 ATP10A NOS2

3.86e-04154994b0735365de153d4586ca17896431d7bd9c7d8eac
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SRGAP2 ATP10A RYR3 ARHGEF26

3.96e-0415599490e629681a72baacc7981b82883866a487638dbc
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SRGAP2 ATP10A RYR3 ARHGEF26

3.96e-04155994e7f49e2fdaf184fa6b4e685518004e7deff1316d
ToppCellChildren_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

MARK1 SPEG LAMA2 PCDH10

3.96e-04155994cd7d95cbcad248670e531d80bb83c55e36ebc573
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SRGAP2 ATP10A RYR3 ARHGEF26

3.96e-041559945a872ca70ae8c30b57f45a6772d7bf565e0c2663
DrugSanguinarine [2447-54-3]; Down 200; 12uM; MCF7; HT_HG-U133A

ZHX3 POLG YTHDC2 PTPRU PLEKHM2 LPIN2 MKI67 MACF1

1.75e-061919884168_DN
DiseaseBrachydactyly syndrome type B

NOG ROR2

1.03e-052952cv:C1300267
Diseasestomach carcinoma (is_marker_for)

ERBB2 KDM4C KDM4A

6.23e-0524953DOID:5517 (is_marker_for)
Diseasemucositis (biomarker_via_orthology)

MKI67 NOS2

1.02e-045952DOID:0080178 (biomarker_via_orthology)
Diseaseinterleukin 2 receptor antagonist measurement

PFKFB3 SNTN ZNF469

1.96e-0435953EFO_0008332
DiseaseHereditary Autoinflammatory Diseases

NLRP3 LPIN2

2.13e-047952C0751422
DiseaseOxidative Phosphorylation Deficiencies

POLG NOS2

3.64e-049952C0949856
DiseaseMitochondrial Respiratory Chain Deficiencies

POLG NOS2

3.64e-049952C0949857
DiseaseElectron Transport Chain Deficiencies, Mitochondrial

POLG NOS2

3.64e-049952C0949855
Diseasealopecia areata (is_marker_for)

KDM4C KDM4A

4.54e-0410952DOID:986 (is_marker_for)
DiseaseAsbestosis

NLRP3 NOS2

9.10e-0414952C0003949
DiseasePulmonary Fibrosis - from Asbestos Exposure

NLRP3 NOS2

9.10e-0414952C2930617
Diseaseresting heart rate

ZHX3 SPEG DGLUCY GAREM1

1.39e-03149954EFO_0004351
DiseaseAutistic Disorder

MARK1 ATP10A PCDH10 NOS2 GABBR1

1.58e-03261955C0004352
Diseaseresponse to methotrexate, neurotoxicity

GPC6 MACF1

1.69e-0319952EFO_0011057, GO_0031427
Diseaseneuroticism measurement, cognitive function measurement

JADE2 PCDHA1 PTPRU SNTN TG PTPRK SLC15A5

2.38e-03566957EFO_0007660, EFO_0008354
DiseaseMalignant neoplasm of breast

ERBB2 VWF LAMA2 ITSN2 MKI67 TREM1 ANKRD30A MACF1 BOD1L1 NOS2

2.41e-0310749510C0006142
Diseaseshort-term memory

SORBS2 PTPRK ITSN2

2.47e-0383953EFO_0004335
DiseaseCarcinoma of lung

ERBB2 MXRA5

2.48e-0323952C0684249
DiseaseIntrahepatic Cholangiocarcinoma

ERBB2 NOS2

2.70e-0324952C0345905
DiseaseExtrahepatic Cholangiocarcinoma

ERBB2 NOS2

2.70e-0324952C3805278
Diseasemalaria (is_implicated_in)

TREM1 NOS2

2.70e-0324952DOID:12365 (is_implicated_in)
Diseaseresponse to peginterferon alfa-2a

VWF ATP10A

2.93e-0325952EFO_0010103
DiseasePeriodontal Pocket

KDM4C DGLUCY

2.93e-0325952EFO_1001393
Diseaseerosive tooth wear measurement

PRMT8 SORBS2 PCDH10

3.10e-0390953EFO_0009331
DiseaseCholangiocarcinoma

ERBB2 NOS2

3.17e-0326952C0206698

Protein segments in the cluster

PeptideGeneStartEntry
GEMPKTLACTERPSK

TREM1

61

Q9NP99
CTGTDMKLRLPASPE

ERBB2

26

P04626
KEPSKTEQLSCMRPA

AMOT

771

Q4VCS5
RRTKVMAKCISPSAG

AIFM3

176

Q96NN9
VCSTGPLTSMQVIKP

FBXW10

936

Q5XX13
GLLKATCGMKVSIPT

ANKRD30A

606

Q9BXX3
PLLMDTICQKTPKDS

ARHGEF26

586

Q96DR7
TQPSCPGRGKMSKLL

PRMT8

51

Q9NR22
PISLKRKSAGSMCIT

CHAF1A

866

Q13111
ELVSGVASPCPKMIS

CASP8AP2

1361

Q9UKL3
PKMAEPSSFVCRSTG

DISP1

1386

Q96F81
TKGKVSMRFSSLCPP

ATP10A

946

O60312
SPVTKKMRLEPGTAA

ADAT1

191

Q9BUB4
LSDMVPTCSALARKP

ARNT2

86

Q9HBZ2
KLASDPRCKGMPLSS

ITSN2

1331

Q9NZM3
RPVTPSCKELADLMT

JAK1

811

P23458
LEKPSRTVTCPMSGK

NOSIP

176

Q9Y314
RTVTCPMSGKPLRMS

NOSIP

181

Q9Y314
CKSKPGLSTSIPLRM

MBD3L1

16

Q8WWY6
RSKSCLGSIMTPKSL

NOS2

111

P35228
TPGICPSLSTMKAIV

PAXIP1

981

Q6ZW49
EREGMPPSSLSSKKT

RELCH

461

Q9P260
SMAISEPIKGSRKPC

PNMA8A

281

Q86V59
PSPAVPKLTMAKCRR

LRCH3

706

Q96II8
SLVPGSATCTVIKPM

NMUR2

196

Q9GZQ4
DPIKIILMPGCSSVS

GABBR1

236

Q9UBS5
PKGFTECEMTKSSPL

ANLN

506

Q9NQW6
RPCKIVEMSTSKTGK

EIF5A2

36

Q9GZV4
PCGALESPMATITKI

KIAA1109

4726

Q2LD37
SIGCPEKMEPITKIS

JADE2

286

Q9NQC1
TRKESKGMCTSPPLI

F13B

516

P05160
TISEDMPLKSPICKV

FAT2

156

Q9NYQ8
MPLKSPICKVTATDA

FAT2

161

Q9NYQ8
SCGPKLTNSPTVIVM

PFKFB3

26

Q16875
MDPAPSLGCSLKDVK

GAREM1

1

Q9H706
KTCPSPREISKVMAS

RASGRP4

31

Q8TDF6
KEVTMDCKTPSNPTG

POLG

1191

P54098
ELGSSSRKTCMDPVP

NFX1

606

Q12986
SRKTCMDPVPSCGKV

NFX1

611

Q12986
RTKPLIPEMCFTSTG

KDM4A

701

O75164
VTSEGKTKPLIPEMC

KDM4C

676

Q9H3R0
IKLCTMPPVGTDLNT

MACF1

2261

O94854
RPCKIVEMSTSKTGK

EIF5A

36

P63241
RGTTMTPPADLIEKC

LAMA2

1366

P24043
LRKRTPSAGKAMDTP

MKI67

2376

P46013
PSVLGPLKRKCEMET

PABIR1

196

Q96E09
KTDLMFLKPCSPSRS

PCDH10

831

Q9P2E7
PKKEETVARCLMPSS

MSL1

451

Q68DK7
GFISPMDDKIPSKCS

FAM13A

921

O94988
LCTMPPVGTDLNTVK

MACF1

6136

Q9UPN3
SRTKCAEPMRAPKGL

PTPRU

376

Q92729
QRVCSSEGPPKTDLM

PCDHA1

756

Q9Y5I3
CPKPLSRVSIMAGSL

GBA

11

P04062
RMGPKKETEGTVTCT

BOD1L1

1716

Q8NFC6
SKVSPTPGCIRALMK

GPC6

236

Q9Y625
TGLVKMSRKPRASSP

CSAG1

31

Q6PB30
MPLGLKPTCSVCKTT

GATAD1

1

Q8WUU5
LLPKRTACPTKNSME

FBXO11

106

Q86XK2
VMKVRIPTCHDKPGT

DENND6A

231

Q8IWF6
CLMALKVPTTEKPTV

EIF4G1

821

Q04637
EMTASPLVGPERKKS

MARK1

471

Q9P0L2
MLVRKALPPGTSSCL

KANSL3

591

Q9P2N6
CGTPLPVSSEKDMIR

EXOC1

566

Q9NV70
TVMTDLKDAKAPPGC

DGLUCY

251

Q7Z3D6
QPLSGKVLTVSSMPC

SLC15A5

416

A6NIM6
ITRTKCAEPMRTPKT

PTPRK

381

Q15262
CAEPMRTPKTLKIAE

PTPRK

386

Q15262
PESKKATSCFPRPMT

NUMA1

2001

Q14980
KRSCSVPEGMVCKPS

NOG

181

Q13253
ASLKSAMIKGCREPP

PLEKHM2

696

Q8IWE5
SLGCTIIEMATSKPP

MAP3K15

836

Q6ZN16
GKTKTCESPVSPIKM

NLRP3

191

Q96P20
MPTKTLRITTRKTPC

RPS20

56

P60866
ECKGMIVTNPGTKPS

DROSHA

736

Q9NRR4
PRKKTIGECSMSLRT

TC2N

316

Q8N9U0
PLSCSPEAMSKRQTV

PRAMEF19

121

Q5SWL8
TSTCAPRKMPKRISI

SNTN

26

A6NMZ2
EMRALACSPKATPKG

SPATA31E1

1371

Q6ZUB1
VPSCSPRDSSKMGIL

ROR2

391

Q01974
PDPKVKSESMGSLLC

SORBS2

396

O94875
RGKLSPSIIEKTMPS

STARD6

176

P59095
PRKMAAKTPSSEESG

CHAT

116

P28329
PVSIGVPATLRCSMK

TRDV2

31

A0JD36
SKRSLSCRPPMVKLV

VWF

761

P04275
PRTAASGPSSKLEKM

SPEG

1156

Q15772
ACVRKKVSPMSPKAT

RP1L1

1661

Q8IWN7
GTMDSPPCLKVTHKT

RYR3

1261

Q15413
MSQSLPKEGPDKCSI

SRGAP2

881

O75044
MASGKDTCPTLPKLT

TEX43

1

Q6ZNM6
MCDVRKGTSTRKPRP

YAF2

41

Q8IY57
SRATPSCPPEMKKEL

TMEM214

371

Q6NUQ4
SCPPEMKKELLSSLT

TMEM214

376

Q6NUQ4
IRPAKSMDSLCSVPV

ARHGAP31

341

Q2M1Z3
KSSRKVAEPELMGTP

CAD

1871

P27708
GATKMPRVTCPSTGL

ZNF469

2361

Q96JG9
CTTAERVLMKSPSPA

YTHDC2

1211

Q9H6S0
SKKPIPECIVSVESM

SFMBT1

421

Q9UHJ3
KLGPRAMSCPEESSL

SOX18

351

P35713
TRDSRGKMLSPATKP

TRMT12

376

Q53H54
KPSSTCGPFRTLDTM

TMC6

676

Q7Z403
TTSLPTSPGDKCRMA

TTLL4

956

Q14679
KSTTPCMIPVKTVVL

ZHX3

6

Q9H4I2
ETGMPKERFSAKCLP

TRBV16

76

A0A087WV62
ESMGCRKDTVPRPAS

TG

1831

P01266
KTTKTRGPKPLCSMP

TTLL7

521

Q6ZT98
KKVCGPSRTNPSMMI

VPS4A

356

Q9UN37
SMEDTVCTIVKPKPR

LPIN2

316

Q92539
KDMTCLKPSIESPLR

MXRA5

271

Q9NR99