Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunction4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity

FUT3 FUT4 FUT7

5.13e-076603GO:0017083
GeneOntologyMolecularFunctionalpha-(1->3)-fucosyltransferase activity

FUT3 FUT4 FUT7

1.43e-068603GO:0046920
GeneOntologyMolecularFunctionfucosyltransferase activity

FUT3 FUT4 FUT7

9.17e-0614603GO:0008417
GeneOntologyMolecularFunctionhexosyltransferase activity

B3GALT4 B4GALT7 FUT3 FUT4 FUT7

4.28e-04211605GO:0016758
GeneOntologyMolecularFunctionvoltage-gated chloride channel activity

CLCNKA CLCNKB

4.80e-0411602GO:0005247
GeneOntologyBiologicalProcessoligosaccharide metabolic process

B3GALT4 MAN2B2 FUT3 FUT4 FUT7

1.19e-0670555GO:0009311
GeneOntologyBiologicalProcessoligosaccharide biosynthetic process

B3GALT4 FUT3 FUT4 FUT7

1.35e-0631554GO:0009312
GeneOntologyBiologicalProcessfucosylation

FUT3 FUT4 FUT7

1.42e-0518553GO:0036065
GeneOntologyBiologicalProcesslymphocyte migration into lymph node

FUT4 FUT7

4.17e-054552GO:0097022
GeneOntologyBiologicalProcesssphingolipid metabolic process

B3GALT4 NAGLU FUT3 FUT4 FUT7

1.05e-04176555GO:0006665
GeneOntologyBiologicalProcessangiogenesis involved in coronary vascular morphogenesis

ACE NRP1

1.45e-047552GO:0060978
GeneOntologyBiologicalProcessvestibulocochlear nerve morphogenesis

DCANP1 NRP1

1.45e-047552GO:0021648
GeneOntologyBiologicalProcessnerve development

DCANP1 NAGLU CHD7 NRP1

2.05e-04109554GO:0021675
GeneOntologyBiologicalProcessceramide metabolic process

B3GALT4 NAGLU FUT3 FUT7

2.35e-04113554GO:0006672
GeneOntologyBiologicalProcessL-fucose catabolic process

FUT4 FUT7

2.48e-049552GO:0042355
GeneOntologyBiologicalProcessfucose catabolic process

FUT4 FUT7

2.48e-049552GO:0019317
GeneOntologyBiologicalProcesscarbohydrate metabolic process

B3GALT4 B4GALT7 ADRB3 MAN2B2 PGGHG FUT3 FUT4 FUT7

2.94e-04646558GO:0005975
GeneOntologyBiologicalProcesslymphocyte migration into lymphoid organs

FUT4 FUT7

3.10e-0410552GO:0097021
GeneOntologyBiologicalProcesstransepithelial chloride transport

CLCNKA CLCNKB

3.10e-0410552GO:0030321
GeneOntologyBiologicalProcessL-fucose metabolic process

FUT4 FUT7

3.10e-0410552GO:0042354
GeneOntologyBiologicalProcessmembrane lipid metabolic process

B3GALT4 NAGLU FUT3 FUT4 FUT7

3.58e-04229555GO:0006643
GeneOntologyBiologicalProcessvestibulocochlear nerve development

DCANP1 NRP1

3.78e-0411552GO:0021562
GeneOntologyBiologicalProcesstrigeminal nerve development

DCANP1 NRP1

5.34e-0413552GO:0021559
GeneOntologyBiologicalProcessmacromolecule glycosylation

B3GALT4 B4GALT7 FUT3 FUT4 FUT7

5.53e-04252555GO:0043413
GeneOntologyBiologicalProcessprotein glycosylation

B3GALT4 B4GALT7 FUT3 FUT4 FUT7

5.53e-04252555GO:0006486
GeneOntologyBiologicalProcessinner ear development

DCANP1 HLA-DMA NAGLU CHD7 MYO15A

5.63e-04253555GO:0048839
GeneOntologyCellularComponentGolgi cisterna membrane

B4GALT7 FUT3 FUT4 FUT7

1.10e-0494554GO:0032580
GeneOntologyCellularComponentGolgi cisterna

B4GALT7 FUT3 FUT4 FUT7

4.40e-04135554GO:0031985
HumanPhenoHypokalemic hypochloremic metabolic alkalosis

CLCNKA CLCNKB

2.42e-053152HP:0004909
HumanPhenoHypochloremic metabolic alkalosis

CLCNKA CLCNKB

4.84e-054152HP:0005977
HumanPhenoAbnormal urine chloride concentration

CLCNKA CLCNKB

8.05e-055152HP:0012600
HumanPhenoHyperchloriduria

CLCNKA CLCNKB

8.05e-055152HP:0002914
HumanPhenoHyperprostaglandinuria

CLCNKA CLCNKB

1.21e-046152HP:0003527
HumanPhenoAbnormal circulating prostaglandin circulation

CLCNKA CLCNKB

1.21e-046152HP:0011023
HumanPhenoHypochloremia

CLCNKA CLCNKB

1.69e-047152HP:0003113
HumanPhenoImpaired renal concentrating ability

CLCNKA CLCNKB

1.69e-047152HP:0004727
HumanPhenoHyperactive renin-angiotensin system

CLCNKA CLCNKB

2.24e-048152HP:0000841
HumanPhenoAbnormal circulating unsaturated fatty acid concentration

CLCNKA CLCNKB

2.24e-048152HP:0011022
HumanPhenoAbnormal circulating eicosanoid concentration

CLCNKA CLCNKB

2.24e-048152HP:0030361
HumanPhenoImpaired renal function

CLCNKA CLCNKB

2.88e-049152HP:0000087
HumanPhenoHypokalemic metabolic alkalosis

CLCNKA CLCNKB

2.88e-049152HP:0001960
HumanPhenoIncreased urinary potassium

CLCNKA CLCNKB

2.88e-049152HP:0003081
HumanPhenoHypernatriuria

CLCNKA CLCNKB

3.59e-0410152HP:0012605
HumanPhenoHypokalemic alkalosis

CLCNKA CLCNKB

5.25e-0412152HP:0001949
HumanPhenoFetal polyuria

CLCNKA CLCNKB

5.25e-0412152HP:0001563
DomainGlyco_transf_10

FUT3 FUT4 FUT7

1.34e-068553PF00852
DomainGlyco_tran_10_N

FUT3 FUT4 FUT7

1.34e-068553PF17039
DomainGlyco_trans_10

FUT3 FUT4 FUT7

1.34e-068553IPR001503
DomainGlyco_tran_10_N

FUT3 FUT4 FUT7

1.34e-068553IPR031481
DomainCl_channel-K

CLCNKA CLCNKB

8.51e-062552IPR002250
Domainig

CEACAM5 TIE1 HLA-DMA ADAMTSL3 LILRA4

2.38e-04190555PF00047
DomainImmunoglobulin

CEACAM5 TIE1 HLA-DMA ADAMTSL3 LILRA4

2.38e-04190555IPR013151
DomainCl-channel_core

CLCNKA CLCNKB

3.02e-049552IPR014743
Domain-

CLCNKA CLCNKB

3.02e-0495521.10.3080.10
DomainVoltage_CLC

CLCNKA CLCNKB

3.02e-049552PF00654
DomainCl-channel_volt-gated

CLCNKA CLCNKB

3.02e-049552IPR001807
DomainIg-like_dom

CEACAM5 CSF3R TIE1 HLA-DMA ROBO3 ADAMTSL3 LILRA4

6.54e-04503557IPR007110
DomainUBA-like

ILRUN UBALD2 TNRC6C

8.87e-0464553IPR009060
DomainCBS

CLCNKA CLCNKB

9.95e-0416552SM00116
DomainCBS_dom

CLCNKA CLCNKB

1.56e-0320552IPR000644
DomainCBS

CLCNKA CLCNKB

1.56e-0320552PF00571
DomainCBS

CLCNKA CLCNKB

1.56e-0320552PS51371
DomainIg-like_fold

CEACAM5 CSF3R TIE1 HLA-DMA ROBO3 ADAMTSL3 LILRA4

4.49e-03706557IPR013783
DomainIGc2

CEACAM5 ROBO3 ADAMTSL3 LILRA4

5.04e-03235554SM00408
DomainIg_sub2

CEACAM5 ROBO3 ADAMTSL3 LILRA4

5.04e-03235554IPR003598
PathwayREACTOME_BLOOD_GROUP_SYSTEMS_BIOSYNTHESIS

B3GALT4 FUT3 FUT4 FUT7

2.33e-0721374M27917
PathwayKEGG_MEDICUS_REFERENCE_SIALYL_LEWIS_X_ANTIGEN_BIOSYNTHESIS

FUT3 FUT4 FUT7

3.31e-076373M47967
PathwayREACTOME_METABOLISM_OF_CARBOHYDRATES

B3GALT4 B4GALT7 MAN2B2 NAGLU FUT3 FUT4 FUT7

8.41e-06288377M16864
PathwayREACTOME_BLOOD_GROUP_SYSTEMS_BIOSYNTHESIS

B3GALT4 FUT4 FUT7

1.10e-0517373MM15629
PathwayKEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES

FUT3 FUT4 FUT7

4.15e-0526373M17377
PathwayKEGG_MEDICUS_REFERENCE_LEWIS_X_ANTIGEN_BIOSYNTHESIS

FUT3 FUT4

6.67e-055372M47966
PathwayREACTOME_METABOLISM_OF_CARBOHYDRATES

B3GALT4 B4GALT7 MAN2B2 NAGLU FUT4 FUT7

6.73e-05271376MM15406
PathwayBIOCARTA_AMAN_PATHWAY

FUT4 FUT7

2.39e-049372MM1535
PathwayBIOCARTA_AMAN_PATHWAY

FUT4 FUT7

6.89e-0415372M22009
Pubmed

Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism.

FUT3 FUT4 FUT7

2.54e-061563311698403
Pubmed

Lack of functional selectin ligand interactions compromises long term tumor protection by CD8+ T cells.

FUT4 FUT7

3.23e-06263222359671
Pubmed

Cloning, tissue distribution, and intrarenal localization of ClC chloride channels in human kidney.

CLCNKA CLCNKB

3.23e-0626328544406
Pubmed

α(1,3)-Fucosyltransferases FUT4 and FUT7 control murine susceptibility to thrombosis.

FUT4 FUT7

3.23e-06263223562273
Pubmed

The ClC-K2 Chloride Channel Is Critical for Salt Handling in the Distal Nephron.

CLCNKA CLCNKB

3.23e-06263227335120
Pubmed

Lack of functional selectin-ligand interactions enhances innate immune resistance to systemic Listeria monocytogenes infection.

FUT4 FUT7

3.23e-06263229345354
Pubmed

Assignment of the genes encoding the human chloride channels, CLCNKA and CLCNKB, to 1p36 and of CLCN3 to 4q32-q33 by in situ hybridization.

CLCNKA CLCNKB

3.23e-0626328812470
Pubmed

The alpha(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis.

FUT4 FUT7

3.23e-0626328752218
Pubmed

Associations between CLCNKA_B tag SNPs with essential hypertension and interactions between genetic and environmental factors in an island population in China.

CLCNKA CLCNKB

3.23e-06263225919862
Pubmed

Targeting kidney CLC-K channels: pharmacological profile in a human cell line versus Xenopus oocytes.

CLCNKA CLCNKB

3.23e-06263224863058
Pubmed

Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel.

CLCNKA CLCNKB

3.23e-0626329916798
Pubmed

Kidney kinetics and chloride ion pumps.

CLCNKA CLCNKB

3.23e-0626329916791
Pubmed

Fucosyltransferase 4 and 7 mediates adhesion of non-small cell lung cancer cells to brain-derived endothelial cells and results in modification of the blood-brain-barrier: in vitro investigation of CD15 and CD15s in lung-to-brain metastasis.

FUT4 FUT7

3.23e-06263231104223
Pubmed

The alpha(1,3)fucosyltransferases FucT-IV and FucT-VII exert collaborative control over selectin-dependent leukocyte recruitment and lymphocyte homing.

FUT4 FUT7

3.23e-06263211485743
Pubmed

Abrogation of functional selectin-ligand expression reduces migration of pathogenic CD8+ T cells into heart.

FUT4 FUT7

3.23e-06263216709814
Pubmed

Memory T cells are enriched in lymph nodes of selectin-ligand-deficient mice.

FUT4 FUT7

3.23e-06263220937846
Pubmed

Expanding Genotype-Phenotype Correlation of CLCNKA and CLCNKB Variants Linked to Hearing Loss.

CLCNKA CLCNKB

3.23e-06263238069401
Pubmed

Selectin ligand-independent priming and maintenance of T cell immunity during airborne tuberculosis.

FUT4 FUT7

3.23e-06263216394002
Pubmed

A regulatory calcium-binding site at the subunit interface of CLC-K kidney chloride channels.

CLCNKA CLCNKB

3.23e-06263220805576
Pubmed

Synthesis of {alpha}(1,3) fucosyltransferases IV- and VII-dependent eosinophil selectin ligand and recruitment to the skin.

FUT4 FUT7

3.23e-06263216127157
Pubmed

Regulation of PSGL-1 interactions with L-selectin, P-selectin, and E-selectin: role of human fucosyltransferase-IV and -VII.

FUT4 FUT7

3.23e-06263215579466
Pubmed

Fuc-TVII is required for T helper 1 and T cytotoxic 1 lymphocyte selectin ligand expression and recruitment in inflammation, and together with Fuc-TIV regulates naive T cell trafficking to lymph nodes.

FUT4 FUT7

3.23e-06263211535629
Pubmed

[Influence of angiotensin converting enzyme gene insertion/deletion polymorphism and beta3-adrenergic receptor gene Trp64Arg polymorphism on fetal growth and neonatal insulin sensitivity].

ADRB3 ACE

3.23e-06263219099777
Pubmed

Fucosyltransferase Induction during Influenza Virus Infection Is Required for the Generation of Functional Memory CD4+ T Cells.

FUT4 FUT7

3.23e-06263229491007
Pubmed

Fucosyltransferase IV and VII-directed selectin ligand function determines long-term survival in experimental tuberculosis.

FUT4 FUT7

3.23e-06263219608009
Pubmed

Salt wasting and deafness resulting from mutations in two chloride channels.

CLCNKA CLCNKB

3.23e-06263215044642
Pubmed

Pathophysiological contributions of fucosyltransferases in renal ischemia reperfusion injury.

FUT4 FUT7

3.23e-06263212193737
Pubmed

Two highly homologous members of the ClC chloride channel family in both rat and human kidney.

CLCNKA CLCNKB

3.23e-0626328041726
Pubmed

A cytoplasmic domain mutation in ClC-Kb affects long-distance communication across the membrane.

CLCNKA CLCNKB

3.23e-06263218648499
Pubmed

Cl(-) channels in basolateral TAL membranes XV. Molecular heterogeneity between cortical and medullary channels.

CLCNKA CLCNKB

3.23e-06263211014860
Pubmed

Silencing α1,3-fucosyltransferases in human leukocytes reveals a role for FUT9 enzyme during E-selectin-mediated cell adhesion.

FUT4 FUT7

9.68e-06363223192350
Pubmed

Murine neutrophils require alpha1,3-fucosylation but not PSGL-1 for productive infection with Anaplasma phagocytophilum.

FUT4 FUT7

9.68e-06363212869507
Pubmed

Human CLC-K Channels Require Palmitoylation of Their Accessory Subunit Barttin to Be Functional.

CLCNKA CLCNKB

9.68e-06363226013830
Pubmed

Barttin increases surface expression and changes current properties of ClC-K channels.

CLCNKA CLCNKB

9.68e-06363212111250
Pubmed

Common genetic variants and haplotypes in renal CLCNKA gene are associated to salt-sensitive hypertension.

CLCNKA CLCNKB

9.68e-06363217510212
Pubmed

A role for leukocyte-endothelial adhesion mechanisms in epilepsy.

FUT4 FUT7

9.68e-06363219029985
Pubmed

Efficient recruitment of lymphocytes in inflamed brain venules requires expression of cutaneous lymphocyte antigen and fucosyltransferase-VII.

FUT4 FUT7

9.68e-06363215843584
Pubmed

Naïve T cells re-distribute to the lungs of selectin ligand deficient mice.

FUT4 FUT7

9.68e-06363220532047
Pubmed

Suppression of tumor formation in lymph nodes by L-selectin-mediated natural killer cell recruitment.

FUT4 FUT7

9.68e-06363216352740
Pubmed

Difucosylated oligosaccharide Lewis Y is contained within integrin αvβ3 on RL95-2 cells and required for endometrial receptivity.

FUT3 FUT4

9.68e-06363220605574
Pubmed

T-cell P/E-selectin ligand alpha(1,3)fucosylation is not required for graft-vs-host disease induction.

FUT4 FUT7

9.68e-06363216338500
Pubmed

Binding of L-selectin to its vascular and extravascular ligands is differentially regulated by pH.

FUT4 FUT7

9.68e-06363221982762
Pubmed

Alpha(1,3)fucosyltransferases FucT-IV and FucT-VII control susceptibility to atherosclerosis in apolipoprotein E-/- mice.

FUT4 FUT7

9.68e-06363215308551
Pubmed

Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities.

FUT3 FUT4

9.68e-0636321740457
Pubmed

Barttin is a Cl- channel beta-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion.

CLCNKA CLCNKB

9.68e-06363211734858
Pubmed

Metastatic growth progression caused by PSGL-1-mediated recruitment of monocytes to metastatic sites.

FUT4 FUT7

9.68e-06363224322980
Pubmed

CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV.

FUT4 FUT7

9.68e-06363211278338
Pubmed

Barttin modulates trafficking and function of ClC-K channels.

CLCNKA CLCNKB

9.68e-06363216849430
Pubmed

Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance.

FUT4 FUT7

9.68e-06363232341362
Pubmed

α(1,3) Fucosyltransferases IV and VII are essential for the initial recruitment of basophils in chronic allergic inflammation.

FUT4 FUT7

9.68e-06363223657464
Pubmed

Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity.

FUT4 FUT7

9.68e-06363222388819
Pubmed

Mechanisms of Disease: the kidney-specific chloride channels ClCKA and ClCKB, the Barttin subunit, and their clinical relevance.

CLCNKA CLCNKB

9.68e-06363218094726
Pubmed

Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Krüppel-like factor, a novel zinc finger repressor.

CLCNKA CLCNKB

9.68e-06363210982849
Pubmed

Haplotype diversity in four genes (CLCNKA, CLCNKB, BSND, NEDD4L) involved in renal salt reabsorption.

CLCNKA CLCNKB

1.93e-05463217652939
Pubmed

Monocyte Induction of E-Selectin-Mediated Endothelial Activation Releases VE-Cadherin Junctions to Promote Tumor Cell Extravasation in the Metastasis Cascade.

FUT4 FUT7

1.93e-05463227488527
Pubmed

The Lewis X-related α1,3-fucosyltransferase, Fut10, is required for the maintenance of stem cell populations.

FUT4 FUT7

1.93e-05463223986452
Pubmed

Arteriogenesis proceeds via ICAM-1/Mac-1- mediated mechanisms.

FUT4 FUT7

1.93e-05463215059933
Pubmed

Cellular players and role of selectin ligands in leukocyte recruitment in a T-cell-initiated delayed-type hypersensitivity reaction.

FUT4 FUT7

1.93e-05463218755847
Pubmed

A novel monoclonal antibody against 6-sulfo sialyl Lewis x glycans attenuates murine allergic rhinitis by suppressing Th2 immune responses.

FUT4 FUT7

1.93e-05463237735247
Pubmed

Heparin-induced leukocytosis requires 6-O-sulfation and is caused by blockade of selectin- and CXCL12 protein-mediated leukocyte trafficking in mice.

FUT4 FUT7

1.93e-05463222194593
Pubmed

Specialized contributions by alpha(1,3)-fucosyltransferase-IV and FucT-VII during leukocyte rolling in dermal microvessels.

FUT4 FUT7

1.93e-05463210894166
Pubmed

Notch-dependent control of myelopoiesis is regulated by fucosylation.

FUT4 FUT7

1.93e-05463218359890
Pubmed

Expression of functional P-selectin glycoprotein ligand 1 on hematopoietic progenitors is developmentally regulated.

FUT4 FUT7

1.93e-05463222461691
Pubmed

Skin-homing receptors on effector leukocytes are differentially sensitive to glyco-metabolic antagonism in allergic contact dermatitis.

FUT4 FUT7

1.93e-05463218056398
Pubmed

The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics.

FUT4 FUT7

3.22e-05563218037890
Pubmed

N-acetylglucosamine-6-O-sulfotransferases 1 and 2 cooperatively control lymphocyte homing through L-selectin ligand biosynthesis in high endothelial venules.

FUT4 FUT7

3.22e-05563216227985
Pubmed

Distinct human α(1,3)-fucosyltransferases drive Lewis-X/sialyl Lewis-X assembly in human cells.

FUT3 FUT4

3.22e-05563229593094
Pubmed

[Correlation of metabolic syndrome clinical signs and genetic determinants at children with obese].

ADRB3 ACE

4.82e-05663221033077
Pubmed

Novel anti-carbohydrate antibodies reveal the cooperative function of sulfated N- and O-glycans in lymphocyte homing.

FUT4 FUT7

4.82e-05663220929857
Pubmed

Embryonic trafficking of gammadelta T cells to skin is dependent on E/P selectin ligands and CCR4.

FUT4 FUT7

4.82e-05663220368416
Pubmed

L-selectin mechanochemistry restricts neutrophil priming in vivo.

FUT4 FUT7

4.82e-05663228497779
Pubmed

Functional contributions of N- and O-glycans to L-selectin ligands in murine and human lymphoid organs.

FUT4 FUT7

4.82e-05663221224079
Pubmed

Genetic association of angiogenesis- and hypoxia-related gene polymorphisms with osteonecrosis of the femoral head.

ACE NRP1

4.82e-05663220215856
Pubmed

Physiological contribution of CD44 as a ligand for E-Selectin during inflammatory T-cell recruitment.

FUT4 FUT7

4.82e-05663221457936
Pubmed

Sialyltransferase ST3Gal-III regulates Siglec-F ligand formation and eosinophilic lung inflammation in mice.

FUT4 FUT7

6.74e-05763223677475
Pubmed

Impairment in renal medulla development underlies salt wasting in Clc-k2 channel deficiency.

CLCNKA CLCNKB

6.74e-05763234499620
Pubmed

DC-SIGN(+) Macrophages Control the Induction of Transplantation Tolerance.

FUT4 FUT7

6.74e-05763226070485
Pubmed

Intrarenal and cellular localization of CLC-K2 protein in the mouse kidney.

CLCNKA CLCNKB

6.74e-05763211423561
Pubmed

Mouse embryonic dorsal root ganglia contain pluripotent stem cells that show features similar to embryonic stem cells and induced pluripotent stem cells.

CHD7 FUT4

8.98e-05863228373172
Pubmed

VEGF mediates commissural axon chemoattraction through its receptor Flk1.

ROBO3 NRP1

8.98e-05863221658588
Pubmed

Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17.

FUT4 FUT7

1.15e-04963215780986
Pubmed

Changing expression of chloride channels during preimplantation mouse development.

CLCNKA CLCNKB

1.15e-04963223115349
Pubmed

Sex differences in environmental and genetic factors for hypertension.

ADRB3 ACE

1.44e-041063218724972
Pubmed

Genetic and environmental factors associated with the development of hypertension in pregnancy.

ADRB3 ACE

1.76e-041163216369102
Pubmed

Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response.

FUT4 FUT7

1.76e-041163219303390
Pubmed

Genetic factors are relevant and independent determinants of antihypertensive drug effects in a multiracial population.

ADRB3 ACE

1.76e-041163219779464
Pubmed

The basic helix-loop-helix transcription factor, dHAND, is required for vascular development.

TIE1 NRP1

2.49e-041363210675351
Pubmed

Neuropilin 1 sequestration by neuropathogenic mutant glycyl-tRNA synthetase is permissive to vascular homeostasis.

TIE1 NRP1

2.49e-041363228835631
Pubmed

CEACAM1 regulates insulin clearance in liver.

CEACAM5 MAP3K10

2.90e-041463211850617
Pubmed

Carcinoembryonic antigen-related cell adhesion molecule-1 regulates granulopoiesis by inhibition of granulocyte colony-stimulating factor receptor.

CEACAM5 CSF3R

3.34e-041563221029969
Pubmed

Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability.

ROBO3 NRP1

3.34e-041563218345009
Pubmed

Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions.

B3GALT4 B4GALT7

3.81e-041663210580128
Pubmed

The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics.

ADRB3 ACE

3.81e-041663215824464
Pubmed

Optic chiasm presentation of Semaphorin6D in the context of Plexin-A1 and Nr-CAM promotes retinal axon midline crossing.

FUT4 NRP1

3.81e-041663222632726
Pubmed

Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.

ADRB3 ACE

3.81e-041663210391210
Pubmed

TRIM24 is an insulin-responsive regulator of P-bodies.

TNRC6C EDC4 GARRE1

4.21e-048063335803934
Pubmed

Comprehensive analysis of low-abundance proteins in human urinary exosomes using peptide ligand library technology, peptide OFFGEL fractionation and nanoHPLC-chip-MS/MS.

NAGLU ACE

4.32e-041763221082674
Pubmed

VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm.

FUT4 NRP1

6.01e-042063221658587
Pubmed

Can we predict top-level sports performance in power vs endurance events? A genetic approach.

ADRB3 ACE

6.01e-042063220459474
Pubmed

Endothelial PlexinD1 signaling instructs spinal cord vascularization and motor neuron development.

SLC10A4 NRP1

7.29e-042263236549270
GeneFamilyFucosyltransferases|Blood group antigens

FUT3 FUT4 FUT7

2.61e-0613393434
GeneFamilyADAM metallopeptidase domain containing|CD molecules

CEACAM5 CSF3R FUT3 FUT4 ACE LILRA4 NRP1

1.86e-05394397471
GeneFamilyChloride voltage-gated channels

CLCNKA CLCNKB

2.02e-0410392302
GeneFamilyImmunoglobulin like domain containing

CEACAM5 TIE1 ROBO3 ADAMTSL3

7.73e-04193394594
GeneFamilyFibronectin type III domain containing

CSF3R TIE1 ROBO3

4.92e-03160393555
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

CEACAM5 ROBO3 ADAMTSL3

5.01e-03161393593
CoexpressionAtlasdev gonad_e12.5_M_SertoliCell_Sox9_k-means-cluster#4_top-relative-expression-ranked_1000

JCAD UBALD2 CHD7 GARRE1

5.85e-0644574gudmap_dev gonad_e12.5_M_SertoliCell_Sox9_k4_1000
CoexpressionAtlasPP_MEG_top-relative-expression-ranked_2500_k-means-cluster#5

CSF3R TIE1 HLA-DMA FUT4 FUT7 CMAHP C16orf54

5.20e-05364577PP_MEG_2500_K5
ToppCellEndothelial-B-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

JCAD LRCH2 TIE1 DACT2 ADAMTSL3

3.62e-061676256a03d16165e0b003092c39972928981abd4a75aa
ToppCellNasal_Brush-Epithelial-Ionocytes|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

CLCNKA CLCNKB LTBP2 LONRF2 NRP1

4.18e-0617262504fabb40fa9357d8902f3b04adc15231626cd9f8
ToppCellNasal_Brush-Epithelial-Ionocytes|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

CLCNKA CLCNKB LTBP2 LONRF2 NRP1

4.18e-06172625dd3a23dc78dc6939f41126f8d7bd23a2e4713647
ToppCellCOVID-19-Epithelial-Ionocytes|Epithelial / Condition, Lineage and Cell class

INTS6L CLCNKA CLCNKB PKD2L1 LTBP2

5.36e-061816254a8d4f2709c1b25f908867f1b2fae1d2d0abf1d4
ToppCellE17.5-Endothelial-capillary_endothelial_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

JCAD TIE1 ACE GARRE1 NRP1

6.28e-0618762561b8a53f29bb8b33c69f680b8359a1143a23999d
ToppCellP03-Endothelial-unknown_endothelial_cell-endothelial_unknown_1|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

JCAD TIE1 ACE GARRE1 NRP1

6.78e-06190625347c7bf67ade235a4e2320db6a75ce0dab8744f9
ToppCellE17.5-Endothelial|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

JCAD TIE1 ACE GARRE1 NRP1

6.78e-061906254fb76195ec9d6e0260a628eef6c2b3705acce787
ToppCellP03-Endothelial-unknown_endothelial_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

JCAD TIE1 ACE GARRE1 NRP1

6.78e-061906250c7da05fbd3f095dde7550585209c056f0b76990
ToppCellPSB-critical-LOC-Epithelial-Ionocyte|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CLCNKA CLCNKB PKD2L1 LTBP2 NRP1

6.96e-061916258f4637e801554e2343b974fe7794f01dd2151418
ToppCellEndothelial-B|World / shred on cell class and cell subclass (v4)

JCAD TIE1 ACE GARRE1 NRP1

6.96e-061916258b7857dee69d0ba3e59e230c9fd372e14695299e
ToppCellfacs-Lung-nan-3m-Endothelial-Capillary_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JCAD TIE1 ACE GARRE1 NRP1

7.14e-061926254bab9754cfd8b9c2d7cc1490e8a29f58c3c26f6c
ToppCellEndothelial|World / shred on cell class and cell subclass (v4)

JCAD TIE1 ACE GARRE1 NRP1

7.14e-061926252b13cca5c4b58628dbbbb356859632dba66d43f9
ToppCellfacs-Lung-18m-Endothelial-capillary_endothelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

JCAD TIE1 ACE GARRE1 NRP1

7.32e-06193625ee4b31d9c92f8fd0d3ddb5e723b82300fcb459d1
ToppCellPND10-Endothelial-Endothelial_blood-vessel|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

JCAD TIE1 ACE GARRE1 NRP1

7.32e-061936251d8acf81dcbfe81c7a73ce50c9f38fe0cbc74486
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

JCAD TIE1 ACE GARRE1 NRP1

7.32e-06193625097a244cf37ce6c1ace9bae56beb7de59442cd6b
ToppCellfacs-Lung-18m-Endothelial-capillary_endothelial-capillary_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

JCAD TIE1 ACE GARRE1 NRP1

7.32e-061936257401e276b644b254c692160d0e7417ec28d50aa4
ToppCellPND10-Endothelial|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

JCAD TIE1 ACE GARRE1 NRP1

7.32e-06193625f3c743b340fc588bc8effd375b12e2c7cbfa49d2
ToppCellPND14-Endothelial|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

JCAD TIE1 ACE GARRE1 NRP1

7.50e-06194625cee89d4340738f09d07a159cd6aeee4300776988
ToppCellPND14-Endothelial-Endothelial_blood-vessel|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

JCAD TIE1 ACE GARRE1 NRP1

7.50e-0619462532962060d80f3edffbe9f0ecad3000c3a9817865
ToppCellfacs-Lung-nan-3m-Endothelial-endothelial_cell_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JCAD TIE1 ACE GARRE1 NRP1

7.50e-06194625f159ef8541d75a4e98468947f231bb463bec922c
ToppCellPND07-Endothelial-Endothelial_blood-vessel|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

JCAD TIE1 ACE GARRE1 NRP1

7.50e-0619462512496bc964d1c572241410524a89ca1a9fdb7e34
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

JCAD TIE1 ACE GARRE1 NRP1

7.50e-0619462546e36817fd1ed27af8013375214c38c9a9271640
ToppCellPND07-Endothelial|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

JCAD TIE1 ACE GARRE1 NRP1

7.50e-06194625d1080c86884916c22894b27994141463f5919812
ToppCellfacs-Lung-18m-Endothelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

JCAD TIE1 ACE GARRE1 NRP1

7.50e-061946253b5ba12375102598468cb09e66af9241b66c3cf9
ToppCelldroplet-Lung-LUNG-1m-Endothelial-Capillary_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JCAD TIE1 ACE GARRE1 NRP1

7.50e-06194625f6c9cc362ccdbc7e790f7c8d1c56cab3557c5306
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

JCAD TIE1 ACE GARRE1 NRP1

7.50e-06194625c6cee7d15af76f9a60d7f414ef0bcc1735c47b7a
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

JCAD TIE1 ACE GARRE1 NRP1

7.50e-0619462544c7d4b75f3b7c9301eba20610e548a01a84ae40
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

JCAD TIE1 ACE GARRE1 NRP1

7.50e-061946257f24023df47935286f185dd428d48797daf26f49
ToppCellPND03-Endothelial-Endothelial_blood-vessel|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

JCAD TIE1 ACE GARRE1 NRP1

7.50e-06194625f93f5148b136819d87faef89707dbaba07d6c2b5
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

JCAD TIE1 ACE GARRE1 NRP1

7.69e-06195625d700e959e060932e3854a9cf294799465efbe18b
ToppCellPND03-Endothelial|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

JCAD TIE1 ACE GARRE1 NRP1

7.89e-06196625a529681d822a95dd1980b7b1c71dc61aaf0baecd
ToppCell3'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

JCAD TIE1 ANXA2R ACE NRP1

8.08e-0619762598e34e8612f111bb667a574de1faaa785d318ca4
ToppCellControl_saline|World / Treatment groups by lineage, cell group, cell type

JCAD TIE1 ACE GARRE1 NRP1

8.49e-0619962511c9c1779caceb725ecccf3f23b7d4e6dbd1af64
ToppCellLPS_IL1RA-Endothelial-Endothelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

JCAD TIE1 ACE GARRE1 NRP1

8.70e-0620062572ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

TIE1 CHD7 ACE GARRE1 NRP1

8.70e-06200625dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellLPS_IL1RA-Endothelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

JCAD TIE1 ACE GARRE1 NRP1

8.70e-062006255c092b2ecc081b5d04476c56333c338cd89ab984
ToppCellControl_saline-Endothelial-Endothelial-Alv_Gen_Intermediate|Control_saline / Treatment groups by lineage, cell group, cell type

JCAD TIE1 ACE GARRE1 NRP1

8.70e-06200625041a34080120c9f613373c20dcc366292f558040
ToppCellControl_saline-Endothelial-Endothelial|Control_saline / Treatment groups by lineage, cell group, cell type

JCAD TIE1 ACE GARRE1 NRP1

8.70e-06200625e77eba6172cabf85b8028638ed35299f2f079cd8
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

JCAD TIE1 ACE GARRE1 NRP1

8.70e-06200625b2d4e6f3e8e4da62e6b02758ab2ed8f505269f9a
ToppCellControl_saline-Endothelial|Control_saline / Treatment groups by lineage, cell group, cell type

JCAD TIE1 ACE GARRE1 NRP1

8.70e-062006253372c488a39fe812fa94e4f0564594186fea3db5
ToppCellControl-Epithelial-Ionocyte|Epithelial / Disease state, Lineage and Cell class

CLCNKA CLCNKB PKD2L1 LTBP2

6.47e-051556244b9369b203a4d7071c56d3d8e6b450e9a0121c41
ToppCelldroplet-Lung-nan-21m-Myeloid-Intermediate_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HLA-DMA APOBEC1 FUT4 ACE

7.32e-051606240b8151037b28f52a21918856a1e9336e8d5edb90
ToppCelldroplet-Trachea-3m-Hematologic-myeloid-granulocyte-granulocyte_l1-4|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CSF3R HLA-DMA APOBEC1 CHD7

7.32e-051606246329b0f02f9509086e563c2ed762a8ec693883b5
ToppCelldroplet-Lung-nan-21m-Myeloid-intermediate_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HLA-DMA APOBEC1 FUT4 ACE

7.32e-051606244738d0c73d8c3508e5b5beb6c61e0ad551d9b949
ToppCellILEUM-non-inflamed-(3)_pDC|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

FUT7 LONRF2 DNAH10OS LILRA4

7.86e-05163624bc5411702badab39143905aa51676b4bbfad2041
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B-B_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

B3GALT4 LINC01599 LILRA4 C16orf54

8.24e-051656247039bb5a7af4684fbd1192230864e5cd6936e83c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B-B_Cell-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

B3GALT4 LINC01599 LILRA4 C16orf54

8.24e-05165624d2c79653710b139794170f3d72f11392fc548ac7
ToppCellTCGA-Colorectal|World / Sample_Type by Project: Shred V9

CEACAM5 APOBEC1 FUT3 FUT4

8.44e-05166624c018cd8c7a82251c67e3dc812d4d21e527a43456
ToppCellILEUM-non-inflamed-(3)_MNP-(3)_pDC|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

LRCH2 LONRF2 DNAH10OS LILRA4

8.64e-051676248ddf9da71a7c4ed53588435db826563a24cee616
ToppCellNS-critical-d_16-33-Epithelial-Ionocyte|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CLCNKA CLCNKB LTBP2 RTKN

8.84e-051686246a233045638cb83dab64789b996b7598c325001e
ToppCellsevere-Myeloid-mDC|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

CEACAM5 HLA-DMA SLC10A4 MRPL3

8.84e-05168624eff37a92d41624924201372cc09f9eb07b60aec1
ToppCellTCGA-Colorectal-Solid_Tissue_Normal-Rectum_normal_tissue|TCGA-Colorectal / Sample_Type by Project: Shred V9

CLCNKB CMTM5 LONRF2 ADAMTSL3

9.04e-0516962441cb92b0558f0d5a3e511058efd9110258b88ee3
ToppCellTCGA-Colorectal-Solid_Tissue_Normal-Rectum_normal_tissue-Rectum_normal_tissue|TCGA-Colorectal / Sample_Type by Project: Shred V9

CLCNKB CMTM5 LONRF2 ADAMTSL3

9.04e-0516962491f4b6a14708e701b2af22989004282041777491
ToppCell3'-Airway_Nasal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ACSM5 FUT7 LONRF2 LILRA4

9.25e-05170624db0ec8b7ecbb4db108fc35c564df4b740f65cc8f
ToppCell3'-Airway_Nasal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ACSM5 FUT7 LONRF2 LILRA4

9.25e-0517062488f6804e973863245ca1c7e5e6656d4a8b824da9
ToppCell3'-Airway_Nasal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ACSM5 FUT7 LONRF2 LILRA4

9.25e-05170624dad3aaf7d9f7bafdbddee51610f03f2359e587ae
ToppCellCOVID_vent-Lymphocytic-Dendritic-pDC|COVID_vent / Disease condition, Lineage, Cell class and subclass

HLA-DMA RTKN LILRA4 NRP1

9.46e-05171624779c951d274ecbd1d546ac425d6c8e718623be5a
ToppCellCOVID_vent-Lymphocytic-Dendritic|COVID_vent / Disease condition, Lineage, Cell class and subclass

HLA-DMA RTKN LILRA4 NRP1

9.46e-05171624debbb071d260639b16269c94d172766908325c58
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic-Neutrophil|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CSF3R SP5 FUT7 C16orf54

9.46e-05171624ef9397cec7f5c217d34583f26270af7ed7fbcebf
ToppCell5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-Myeloid-pDC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HLA-DMA FUT7 LILRA4 C16orf54

9.68e-05172624d40a8bd61114b49a5837c836136a13c37c8f7de0
ToppCellHippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Ibsp-Inhibitory_Gad1Gad2_Htr3a.Ibsp_(Interneuron,__(candidate_CGE-derived_7))|Hippocampus / BrainAtlas - Mouse McCarroll V32

MEIOSIN FUT4 FUT7

9.78e-0564623c13a7edad4d52a955e2c2247139246522d9e4463
ToppCellHippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Ibsp-Inhibitory_Gad1Gad2_Htr3a.Ibsp_(Interneuron,__(candidate_CGE-derived_7))-|Hippocampus / BrainAtlas - Mouse McCarroll V32

MEIOSIN FUT4 FUT7

9.78e-0564623eefb4573ec4ff8efe602543ccbe555dbef1c4d54
ToppCellHippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Ibsp|Hippocampus / BrainAtlas - Mouse McCarroll V32

MEIOSIN FUT4 FUT7

9.78e-0564623fcc0f3fa0b462620d031aae810a01fadb7c01202
ToppCellBronchial_Brush-Epithelial-Ionocytes|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

CLCNKA CLCNKB PKD2L1 LTBP2

9.90e-05173624e1de849dcd96063136bdac87e050ddbd55cabdcc
ToppCellBronchial_Brush-Epithelial-Ionocytes|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

CLCNKA CLCNKB PKD2L1 LTBP2

9.90e-05173624f2a8f4918c1fb68d98bc3f33cd624de0f0f11e06
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Myeloid_Dendritic_Type_1|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

INTS6L B4GALT7 HLA-DMA FUT7

1.01e-04174624ff13a5c55d18b951315908f33cb47c7f9cb901bf
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Endothelial|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSF3R TIE1 CMTM5 C16orf54

1.03e-04175624c36b4526970db9ccfbe2c70b00961fab9f13b133
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Endothelial-endothelial_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSF3R TIE1 CMTM5 C16orf54

1.03e-04175624c1e082538f31b5c98ac63f71dcca4a1211a14708
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Endothelial-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSF3R TIE1 CMTM5 C16orf54

1.03e-041756242f9b5bdf8a62e8e99d1c4f677a8e5525bfd3b4ce
ToppCellmild-Myeloid-pDC|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

TIE1 RTKN LILRA4 NRP1

1.06e-0417662459a9c262c252b7d220a025837922d98e9d6b0a24
ToppCell3'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-cDC1|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CEP85 HLA-DMA SPAG8 FUT7

1.06e-0417662487f90834c7278516beff7814b78f7c75732d9bf0
ToppCellfacs-Aorta|facs / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JCAD TIE1 LTBP2 NRP1

1.06e-041766240b3491451be02c18a16cdb875645be47eb867a7f
ToppCell3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CLCNKA CLCNKB APOBEC1 LTBP2

1.08e-041776246d89042bda8e244babb68929e84b25edcb545a77
ToppCell3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CLCNKA CLCNKB APOBEC1 LTBP2

1.08e-04177624daaccf1249dcf816df4caca695a944f53078291a
ToppCell3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CLCNKA CLCNKB APOBEC1 LTBP2

1.08e-04177624338bdda26796bf4e16072878c070212d1006cf57
ToppCelltumor_Lung-Endothelial_cells-EPCs|tumor_Lung / Location, Cell class and cell subclass

JCAD TIE1 ACE GARRE1

1.08e-04177624f8b152c09d56a97e8c0482fb1a3964c05f9dc8c5
ToppCell3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CLCNKA CLCNKB APOBEC1 LTBP2

1.08e-04177624c5a16f984c836dbf7d0faf061677844167ab612a
ToppCellNS-critical-LOC-Epithelial-Ionocyte|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CLCNKA CLCNKB LTBP2 RTKN

1.13e-0417962465a96bee7bc28f5bfc20f0fd92bcc0ab2eb5e06c
ToppCellmetastatic_Brain-Myeloid_cells-CD207+CD1a+_LCs|metastatic_Brain / Location, Cell class and cell subclass

ADRB3 HLA-DMA FUT7 LILRA4

1.15e-0418062451727cb66fe7a7709453f7026e0ff3d6c93d5aa5
ToppCelldroplet-Liver-Npc-21m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JCAD TIE1 GARRE1 NRP1

1.20e-04182624dc55de945c6f78f32eb3a1b3520835eb8417e068
ToppCelltumor_Lung-Myeloid_cells-CD207+CD1a+_LCs|tumor_Lung / Location, Cell class and cell subclass

DCANP1 ADRB3 HLA-DMA LILRA4

1.20e-04182624243779ba1009097f8fafa1a691e296ec3aeefc04
ToppCell10x3'2.3-week_14-16-Endothelial-stroma-proliferating_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

JCAD LRCH2 TIE1 NRP1

1.20e-04182624997d37ca2af661c92a56add888762724dfccc890
ToppCellChildren_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

JCAD TIE1 ACE NRP1

1.20e-04182624a20017b6a4f9a6a29e090e4dbd7c02ed1495bd50
ToppCellE18.5-samps-Endothelial-Mature_fetal_endothelial|E18.5-samps / Age Group, Lineage, Cell class and subclass

JCAD TIE1 ACE GARRE1

1.20e-041826247af3b2029b7f55b923d5a4b764d4292f4ea48599
ToppCellE16.5-samps-Endothelial-Immature_fetal_endothelial-Intermediate_Endothelial|E16.5-samps / Age Group, Lineage, Cell class and subclass

JCAD TIE1 ACE GARRE1

1.20e-04182624fec1caf867b1dc87b24504d895ee1a27df78062e
ToppCellE18.5-samps-Endothelial|E18.5-samps / Age Group, Lineage, Cell class and subclass

JCAD TIE1 ACE GARRE1

1.20e-04182624e2d799e6e7526176a6fe6515b8fbe4d83d3a3ea1
ToppCelldroplet-Liver-Npc-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JCAD TIE1 GARRE1 NRP1

1.20e-04182624010a7364da46101cb5068891fd7bc712ea8f13bd
ToppCelldroplet-Liver-Npc-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JCAD TIE1 GARRE1 NRP1

1.20e-04182624b1ec2015aad1181eac1bbf8d48ad6f2f7ed24a01
ToppCellControl-Endothelial-Endothelial-Activated_Alv_Cap|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

JCAD TIE1 ACE NRP1

1.23e-04183624e81c142770f44fd902b0631bc360c5b5339d4c75
ToppCellPND14|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

INTS6L HLA-DMA ACE NRP1

1.25e-041846241bfee4eb121e76a79f48b06b45f05d124fbbedba
ToppCell(4)_Endothelial_cells-(40)_EC-arterial|World / Cell class and subclass of bone marrow stroma cells in homeostatis

TIE1 ACE NRP1 C16orf54

1.25e-041846247e1a2971321ddcfa00d78d3e3ba7960e532f9392
ToppCellURO-Myeloid-pDC|URO / Disease, Lineage and Cell Type

HLA-DMA FUT7 LILRA4 NRP1

1.25e-041846240edb5dd003c2bca0b9e3ec18d03610d68bd52538
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

MAP3K10 CHD7 GARRE1

1.28e-047062337e34ef782b253c43628d5bb2fe5e0294573d0ef
ToppCellControl-Endothelial-Endothelial-Alv_Cap|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

JCAD TIE1 ACE NRP1

1.34e-04187624ea9d34bcd3bd1f36745846309ede349773de501a
ToppCellE17.5-Endothelial-capillary_endothelial_cell-capillary_endothelial_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

JCAD TIE1 ACE GARRE1

1.34e-04187624e9aa0a5a0f8e2593de63e83b56b53ae33e60af49
ToppCellE17.5-Endothelial-unknown_endothelial_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

JCAD TIE1 ACE NRP1

1.34e-04187624da885c26ccc5189b1ff1f607552e00a5c0e49e7e
ToppCellE12.5-Epithelial-epithelial_progenitor_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SLC10A4 DACT2 SP5 CHD7

1.34e-04187624ab6f4d387218b4651fdadbf269806c1ddc96a1d2
ToppCellfacs-Aorta-Heart-3m-Endothelial-nan|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JCAD TIE1 GARRE1 NRP1

1.34e-04187624df0279b7e94e26f5541b0e2a0ce56befa96ec8ca
ToppCellE17.5-Endothelial-unknown_endothelial_cell-endothelial_unknown_1|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

JCAD TIE1 ACE NRP1

1.34e-041876241f358d02ec69d44dea2e2831af9473ed05dcf8cc
ToppCellMonocytes-M2-like_CD16+_macrophages|Monocytes / Immune cells in Kidney/Urine in Lupus Nephritis

JCAD ACSM5 LTBP2 NRP1

1.34e-0418762459e31c51183ed4c9a3d0792c8005ea3a12b28dfa
DrugAC1MPID6

FUT3 FUT4 FUT7

3.82e-076623CID003411618
DrugAC1MQWF5

FUT3 FUT4 FUT7

2.28e-0610623CID003458642
Drug3'SLN

FUT3 FUT4 FUT7

8.55e-0615623CID000643986
DrugGrape Seed Proanthocyanidins

VN1R3 TUBGCP6 PGGHG CLCNKB ANXA2R NAGLU PKD2L1 ZNF74 C22orf39 TNRC6C FUT3

1.68e-058526211ctd:C511402
DrugBenzydamine hydrochloride [132-69-4]; Up 200; 11.6uM; MCF7; HT_HG-U133A

PGGHG ROBO3 SPAG8 MYO15A FUT7 LILRA4

1.69e-051996263169_UP
DrugAC1MPID3

FUT3 FUT4 FUT7

1.81e-0519623CID003411617
Drug(2S,3R,4S,5S,6R)-2-benzyl-6-(hydroxymethyl)oxane-3,4,5-triol

FUT3 FUT4 FUT7

3.28e-0523623CID010332525
DrugCatechin

VN1R3 TUBGCP6 PGGHG CLCNKB ANXA2R NAGLU PKD2L1 ZNF74 C22orf39 TNRC6C FUT3

3.68e-059286211ctd:D002392
Drugf119

HLA-DMA ACE

4.36e-054622CID000009602
DrugAC1L1B78

MAN2B2 PKD2L1 MYO15A ACE

4.46e-0572624CID000001313
DrugsLex

CEACAM5 FUT3 FUT4 FUT7

4.46e-0572624CID004564901
DrugH S Q

B4GALT7 CEACAM5 MAN2B2 CLCNKA NAGLU SH2D3A FUT3

4.63e-05351627CID000000897
Drugrhamnose

CEACAM5 MAN2B2 NAGLU FUT3 FUT4 FUT7 ACE

5.06e-05356627CID000000840
DrugsLea

CEACAM5 FUT3 FUT4 FUT7

6.11e-0578624CID000643993
Drug2-Methyl-4-chlorophenoxyacetic Acid

CLCNKA CLCNKB

7.26e-055622ctd:D008456
Drug2'-fucosyllactose

FUT3 FUT4 FUT7

7.41e-0530623CID000170484
Drugp904

B4GALT7 MAN2B2 NAGLU FUT3 FUT4 FUT7

8.72e-05267626CID000065150
Druglacto-N-tetraose

FUT3 FUT4 FUT7

9.01e-0532623CID000440993
Drugvaleric anhydride

HLA-DMA ACE

1.09e-046622CID000074959
DiseaseBartter disease type 4B

CLCNKA CLCNKB

3.93e-062592cv:C4310805
DiseaseBARTTER SYNDROME, TYPE 4B

CLCNKA CLCNKB

3.93e-062592C2751312
DiseaseBARTTER SYNDROME, TYPE 4B, NEONATAL, WITH SENSORINEURAL DEAFNESS

CLCNKA CLCNKB

3.93e-062592C4310805
DiseaseBartter disease type 3 (implicated_via_orthology)

CLCNKA CLCNKB

3.93e-062592DOID:0110144 (implicated_via_orthology)
DiseaseBartter disease type 4b (is_implicated_in)

CLCNKA CLCNKB

3.93e-062592DOID:0110146 (is_implicated_in)
DiseaseBARTTER SYNDROME, TYPE 4B, NEONATAL, WITH SENSORINEURAL DEAFNESS

CLCNKA CLCNKB

3.93e-062592613090
DiseaseBartter disease (implicated_via_orthology)

CLCNKA CLCNKB

3.93e-062592DOID:445 (implicated_via_orthology)
DiseaseBartter syndrome

CLCNKA CLCNKB

5.87e-056592cv:C0004775
Diseasecandidiasis (implicated_via_orthology)

FUT3 FUT4 FUT7

9.49e-0544593DOID:1508 (implicated_via_orthology)
Diseasenephrogenic diabetes insipidus (implicated_via_orthology)

CLCNKA CLCNKB

1.75e-0410592DOID:12387 (implicated_via_orthology)
Diseaseserum carcinoembryonic antigen measurement

CEACAM5 FUT3

7.30e-0420592EFO_0005760
Diseasebipolar disorder, schizophrenia, response to lithium ion

HLA-DMA CMAHP

7.30e-0420592GO_0010226, MONDO_0004985, MONDO_0005090
DiseaseLeft Ventricular Hypertrophy

ADRB3 ACE

1.14e-0325592C0149721
Diseasehypertension (is_implicated_in)

ADRB3 CLCNKB ACE

1.85e-03121593DOID:10763 (is_implicated_in)
Diseasesensorineural hearing loss (is_implicated_in)

CLCNKA MYO15A

1.99e-0333592DOID:10003 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
VWAPRQSPPPDWHLP

C22orf39

121

Q6P5X5
SDPWHPPSLSPNSWN

DCANP1

181

Q8TF63
PGDEAHWPQYPPLWM

APOBEC1

161

P41238
LGWPEYQWHPPLPDN

ACE

621

P12821
ESEWAPWQPQLPCEP

DNAH10OS

101

P0CZ25
MESPSAPPHRWCIPW

CEACAM5

1

P06731
VSEEQWPHTWGPFPP

B3GALT4

246

O96024
RVEGPPAWEAAPWPS

C16orf54

11

Q6UWD8
LEEAGHRPPNPAFWW

ACSM5

66

Q6NUN0
MAPWPHENSSLAPWP

ADRB3

1

P13945
LPWSSPLHPWDRQQD

ANXA2R

121

Q3ZCQ2
VWIPEPFHAEVPADW

CHD7

1771

Q9P2D1
NLHTWDGPLPPSWHI

NAGLU

206

P54802
HQVAEPPEDWPALIW

EDC4

941

Q6P2E9
HWPIPESFWPDQNLP

INTS6L

286

Q5JSJ4
PPEFWVSAHPGWLQV

KIRREL3-AS3

61

Q8N7Y1
PRPWAPHALPFWDTP

SLC10A4

86

Q96EP9
LWAEPGPVITWHNPV

LILRA4

31

P59901
PWEPTPSAPPARWGH

MAP3K10

651

Q02779
APAHVPPAPQASWWA

MYO15A

706

Q9UKN7
PPAPQASWWAFVEPP

MYO15A

711

Q9UKN7
PPWHRWGTLPQAAAP

MYO15A

1076

Q9UKN7
PPDWPPPWGIQAHTA

FUT4

246

P22083
WSEELQPGHPRAWPP

JCAD

916

Q9P266
PPEPPPEHWEEDASW

B4GALT7

76

Q9UBV7
VWHWPFTDQPPELPS

FUT7

51

Q11130
APTQPWWPNTPGDSV

TUBGCP6

1351

Q96RT7
EPEPQSNPSGPAWSW

LONRF2

686

Q1L5Z9
GLPPAHDPWEPKPDW

SLC9A3R2

111

Q15599
AGPWAPHLEAELWPS

PGGHG

651

Q32M88
WLPAWTPENSPQGSP

MEIOSIN

326

C9JSJ3
WALPPAPHSYINEWL

NRP1

471

O14786
NTWAPAPDTWAPAPD

ILRUN

241

Q9H6K1
AAPQPSLEWDPAHWP

DACT2

526

Q5SW24
PHAWWVPPTAPGTSL

LINC01599

266

Q8WXQ3
NWPPMDDAHRTWPFP

GARRE1

876

O15063
PLPSQVWQPSPDTWH

CEP85

261

Q6P2H3
LPHSWAVPEAPTPMW

HLA-DMA

21

P28067
DPHSLWVGWEPPNPW

CSF3R

441

Q99062
PPPWLPASPGHSLWD

LTBP2

511

Q14767
WPAPRGHLDPTWALQ

MAN2B2

391

Q9Y2E5
VEPSWPWHPGLEQAA

LINC02913

131

Q8NAJ2
DEQPWPESHPIIWQS

LRCH2

536

Q5VUJ6
KDEPWPIHPWEPGSF

MRPL3

81

P09001
WLEPWSGQPAHPPLN

FUT3

171

P21217
VAPAPDWTHPLPWGR

RTKN

501

Q9BST9
PWEPPAAWELQEAPA

RTL3

96

Q8N8U3
SSINWPPEFHPGVPW

TNRC6C

1381

Q9HCJ0
WSQHCPWEPQKQPPW

SPAG8

231

Q99932
AVWSGHSPPPPQENW

REPS1

216

Q96D71
NPAPDDLPWWSIPQA

SP5

181

Q6BEB4
PGVVTSPELPEHWWQ

SPATA31E1

616

Q6ZUB1
PPLVRGPWHNTNSPW

DIP2C-AS1

91

Q8N8Z3
PAFARGWWLLHEPPS

CMAHP

61

Q9Y471
PGWHTPAAVPWVPAP

CMTM5

126

Q96DZ9
PPWPEELDPQHLWWE

CLCNKA

376

P51800
PPWPEELDPQHLWWE

CLCNKB

376

P51801
NHWPADTSLQPIHPW

WFDC5

176

Q8TCV5
APPTPAPDHWWMEAP

nan

76

Q8N377
PSQSCPEPEAPWWEA

SH2D3A

246

Q9BRG2
DCPEPLLQPWLEGWH

TIE1

541

P35590
PAPYSWLADSWPHPS

ROBO3

956

Q96MS0
WKHPQPAPAVTPDPW

PKD2L1

756

Q9P0L9
PFWASSPPSHQAPWI

UBALD2

111

Q8IYN6
AAPWAPAPAMVWDVP

ZNF74

161

Q16587
PPSLHMSLFPNPSWW

VN1R3

251

Q9BXE9
PPPQEPFWEPGNWSH

ADAMTSL3

1421

P82987