Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF28 TFAP2D CSRNP3 MYOG ZNF423 TP63 ZNF644 ZNF451 MAZ NKX2-3 ZBTB40 PLAGL2 ZNF350 ZNF860 ZNF772 SIX3 CREB3L1 NOTCH2 ZNF646	2.28e-05	1412	93	19	GO:0000981
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	NKD2 PI4KA MAZ XRN1 LMTK2 NAV1 FAM83G COBL TANC1 TNFAIP3 SIK3 AKAP1 NOTCH2 CRTC2 FAM110B	1.25e-08	861	95	15	36931259
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ATN1 ANAPC1 MAZ NFKBIL1 XRN1 PEX1 TANC1 ZNF318 HSD11B1 SIK3 RALGAPA2 TUBGCP5 NSRP1 NOTCH2 ZNF646	3.59e-07	1116	95	15	31753913
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	ATRN RANBP2 ZNF28 ATN1 NKD2 ANAPC1 ZNF644 ZNF451 SCARB1 MAZ ARID5B THAP12 NSRP1 NOTCH2 ZNF646	9.21e-07	1203	95	15	29180619
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	CASP8AP2 RANBP2 ANAPC1 ZNF644 ARID5B XRN1 NAV1 ZNF318 AKAP1	2.27e-06	418	95	9	34709266
Pubmed	A census of human transcription factors: function, expression and evolution.	ZNF28 TFAP2D MYOG TP63 ZNF644 ZNF451 MAZ NKX2-3 PLAGL2 SIX3 THAP12 CREB3L1	7.00e-06	908	95	12	19274049
Pubmed	Identification of a tissue-specific putative transcription factor in breast tissue by serological screening of a breast cancer library.	ANKRD30A ANKRD30B	7.38e-06	2	95	2	11280766
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PI4KA NBEAL2 NISCH SCARB1 KIAA0319L LMTK2 NAV1 COBL LAMC3 TANC1 TNFAIP3 RALGAPA2 NOTCH2	9.81e-06	1105	95	13	35748872
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CASP8AP2 NBEAL2 DDHD1 LMTK2 PLAGL2 CACNA1G DIXDC1 SIK3 ZNF646	1.50e-05	529	95	9	14621295
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	PI4KA NBEAL2 SCARB1 KIAA0319L NAV1 COBL TANC1 RALGAPA2 NOTCH2	2.66e-05	569	95	9	30639242
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	CASP8AP2 ANAPC1 PI4KA ZNF644 ZNF451 ARID5B NAV1 TANC1 ZNF318	3.43e-05	588	95	9	38580884
Pubmed	E-cadherin expression on multiple myeloma cells activates tumor-promoting properties in plasmacytoid DCs.	XRN1 TNFAIP3 TLR9	6.16e-05	28	95	3	30277474
Pubmed	Engagement of platelet toll-like receptor 9 by novel endogenous ligands promotes platelet hyperreactivity and thrombosis.	SCARB1 TLR9	7.34e-05	5	95	2	23071157
Pubmed	STK11 is required for the normal program of ciliated cell differentiation in airways.	TP63 SIK3 NOTCH2	8.40e-05	31	95	3	31636950
Pubmed	Conditional ablation of the Notch2 receptor in the ocular lens.	TP63 DIXDC1 NOTCH2	8.40e-05	31	95	3	22173065
Pubmed	14-3-3 proteins mediate inhibitory effects of cAMP on salt-inducible kinases (SIKs).	SIK3 CRTC2	1.10e-04	6	95	2	29211348
Pubmed	Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site.	MYOG SIX3	1.10e-04	6	95	2	9826681
Pubmed	11β-Hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation.	MYOG HSD11B1	1.10e-04	6	95	2	27578244
Pubmed	Notch1 maintains dormancy of olfactory horizontal basal cells, a reserve neural stem cell.	TP63 NOTCH2	1.10e-04	6	95	2	28637720
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	ATN1 NKD2 GLYR1 ZNF423 COBL GRIN2A MTUS2 NOTCH2	1.53e-04	560	95	8	21653829
Pubmed	IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes.	TP63 NOTCH2	1.54e-04	7	95	2	21909072
Pubmed	A review and comparison of the murine alpha1-antitrypsin and alpha1-antichymotrypsin multigene clusters with the human clade A serpins.	SERPINA1 SERPINA9	1.54e-04	7	95	2	12659817
Pubmed	A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC.	NFKBIL1 NCR3	1.54e-04	7	95	2	10202016
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ZNF451 DDHD1 DIXDC1 TANC1	1.81e-04	102	95	4	11214970
Pubmed	Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation.	CASP7 THAP12	2.05e-04	8	95	2	11555640
Pubmed	Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract.	ATN1 CASP7	2.62e-04	9	95	2	9535906
Pubmed	Analysis of a new allele of limb deformity (ld) reveals tissue- and age-specific transcriptional effects of the Ld Global Control Region.	SCG5 RYR3	2.62e-04	9	95	2	17554679
Pubmed	Analyses of the circadian clock genes expression in whole embryos and maternal major tissues of mice.	MYOG MAZ	2.62e-04	9	95	2	35149920
Pubmed	Genetic polymorphisms and susceptibility to lung disease.	SERPINA1 TLR9	3.28e-04	10	95	2	16608528
Pubmed	Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK.	APBA1 GRIN2A	3.28e-04	10	95	2	18054859
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	APBA1 NAV1 COBL DIXDC1	3.37e-04	120	95	4	31413325
Pubmed	A human MAP kinase interactome.	CASP8AP2 RANBP2 ZNF451 NAV1 COBL TNFAIP3 SIK3	3.82e-04	486	95	7	20936779
Pubmed	Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300.	TP63 SIX3	4.00e-04	11	95	2	24038357
Pubmed	lunatic fringe is an essential mediator of somite segmentation and patterning.	MYOG NOTCH2	4.00e-04	11	95	2	9690473
Pubmed	Defects in somite formation in lunatic fringe-deficient mice.	MYOG NOTCH2	4.00e-04	11	95	2	9690472
Pubmed	Homeobox genes and connective tissue patterning.	MYOG SIX3	4.00e-04	11	95	2	7720577
Pubmed	Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation.	MYOG NOTCH2	4.00e-04	11	95	2	9242490
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	ATN1 NISCH DDHD1 XRN1 PEX1 TANC1 SIK3 CRTC2	4.16e-04	650	95	8	38777146
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	RANBP2 ZNF644 PEX1 NAV1 CASP7	4.50e-04	232	95	5	25515538
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	PI4KA NISCH SCARB1 KIAA0319L PEX1 AKAP1 NOTCH2	4.75e-04	504	95	7	34432599
Pubmed	Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure.	MYOG NOTCH2	4.79e-04	12	95	2	12421720
Pubmed	Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of 3 population-based case-control studies.	CASP8AP2 CASP7	4.79e-04	12	95	2	19414860
Pubmed	Wnt signaling from the dorsal neural tube is required for the formation of the medial dermomyotome.	MYOG NOTCH2	5.65e-04	13	95	2	9811581
Pubmed	Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins.	TNFAIP3 TLR9	5.65e-04	13	95	2	30108181
Pubmed	Applying gene expression, proteomics and single-nucleotide polymorphism analysis for complex trait gene identification.	SCARB1 HSD11B1	5.65e-04	13	95	2	18245842
Pubmed	Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population.	COL7A1 NBEAL2 TLR9	6.64e-04	62	95	3	19367581
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	CASP8AP2 PI4KA GLYR1 ZNF644 ZNF451 NISCH SMU1 TANC1 SIK3 AKAP1 NSRP1 NOTCH2	7.35e-04	1487	95	12	33957083
Pubmed	Genetic pathway-based hierarchical clustering analysis of older adults with cognitive complaints and amnestic mild cognitive impairment using clinical and neuroimaging phenotypes.	APBA1 CASP7	7.57e-04	15	95	2	20468060
Pubmed	Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants.	MYOG NOTCH2	7.57e-04	15	95	2	17194759
Pubmed	Multiple roles of Notch signaling in the regulation of epidermal development.	TP63 NOTCH2	7.57e-04	15	95	2	18410734
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	CSNK1G3 PI4KA GLYR1 DDHD1 ARID5B ZBTB40 PEX1 LMTK2 ZNF318 TNFAIP3	7.65e-04	1084	95	10	11544199
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ATRN ZNF423 ZNF451 NISCH KIAA0319L ARID5B APBA1 ZNF350 TUBGCP5 MTUS2 RYR3	7.67e-04	1285	95	11	35914814
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	RANBP2 NKD2 XRN1 TANC1 ZNF318	7.93e-04	263	95	5	34702444
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	CASP8AP2 RANBP2 TFAP2D ANAPC1 GLYR1 ZNF644 MAZ NFKBIL1 ARID5B SMU1 ZNF318	8.12e-04	1294	95	11	30804502
Pubmed	Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.	TP63 ARID5B	8.64e-04	16	95	2	22076464
Pubmed	Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis.	TP63 PTCH2	8.64e-04	16	95	2	23034632
Pubmed	Epidermal hyperplasia and expansion of the interfollicular stem cell compartment in mutant mice with a C-terminal truncation of Patched1.	TP63 PTCH2	8.64e-04	16	95	2	17631878
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ZNF423 ZNF644 ZNF451 NISCH NAV1 COBL	8.96e-04	407	95	6	12693553
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	ANAPC1 ZNF451 DDHD1 XRN1 NAV1 PRR14L TANC1 AKAP1	9.10e-04	733	95	8	34672954
Pubmed	Requirement of zinc transporter ZIP10 for epidermal development: Implication of the ZIP10-p63 axis in epithelial homeostasis.	SLC39A12 TP63	9.78e-04	17	95	2	29078349
Pubmed	The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments.	MYOG NOTCH2	9.78e-04	17	95	2	15155583
Pubmed	Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.	SCG5 NKX2-3	9.78e-04	17	95	2	24737748
Pubmed	Cytoplasmic dynein-1 cargo diversity is mediated by the combinatorial assembly of FTS-Hook-FHIP complexes.	KIAA0319L LMTK2 AKAP1	1.03e-03	72	95	3	34882091
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	CSNK1G3 PI4KA NISCH COBL RALGAPA2 NOTCH2	1.07e-03	421	95	6	36976175
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	CASP8AP2 PI4KA GLYR1 OR10K1 PEX1 COBL CACNA1G AKAP1	1.09e-03	754	95	8	35906200
Pubmed	Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1.	NFKBIL1 NCR3	1.10e-03	18	95	2	19143814
Pubmed	AP-SWATH Reveals Direct Involvement of VCP/p97 in Integrated Stress Response Signaling Through Facilitating CReP/PPP1R15B Degradation.	PEX1 THAP12 RYR3	1.20e-03	76	95	3	29599191
Pubmed	A Wnt/Notch/Pax7 signaling network supports tissue integrity in tongue development.	MYOG TP63	1.22e-03	19	95	2	28438836
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	RANBP2 ATN1 ANAPC1 ZNF644 ZBTB40 ZNF318 AKAP1 NOTCH2	1.29e-03	774	95	8	15302935
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	RANBP2 ANAPC1 PI4KA NISCH NAV1 DIXDC1 ZNF318 GRIN2A SIK3	1.29e-03	963	95	9	28671696
Pubmed	Cellular substrates and pro-apoptotic function of the human HtrA4 protease.	RANBP2 CASP7 COBL NSRP1	1.32e-03	173	95	4	31470122
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	RANBP2 ANAPC1 NISCH LMTK2 ZNF318 THAP12	1.33e-03	440	95	6	34244565
Pubmed	Trans-ancestry analysis reveals genetic and nongenetic associations with COVID-19 susceptibility and severity.	RANBP2 MALRD1	1.36e-03	20	95	2	33888907
Pubmed	A year of COVID-19 GWAS results from the GRASP portal reveals potential genetic risk factors.	RANBP2 MALRD1	1.36e-03	20	95	2	35224516
Pubmed	The formation and function of the cardiac conduction system.	CACNA1G NOTCH2	1.50e-03	21	95	2	26786210
Pubmed	Differential requirement of SUFU in tissue development discovered in a hypomorphic mouse model.	TP63 PTCH2	1.50e-03	21	95	2	28688895
Pubmed	Jagged and Delta-like ligands control distinct events during airway progenitor cell differentiation.	CYP2F1 TP63	1.50e-03	21	95	2	31631837
Pubmed	Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1.	SERPINA1 SERPINA9	1.50e-03	21	95	2	15014966
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	TFAP2D KIAA0319L NOTCH2 CRTC2	1.53e-03	180	95	4	35198878
Pubmed	Pax6 regulates craniofacial form through its control of an essential cephalic ectodermal patterning center.	TP63 SIX3	1.65e-03	22	95	2	21309073
Pubmed	E3 ubiquitin ligase FBXW7 balances airway cell fates.	TP63 NOTCH2	1.65e-03	22	95	2	34998785
Pubmed	TCF7L2 regulates postmitotic differentiation programmes and excitability patterns in the thalamus.	CACNA1G SIX3	1.65e-03	22	95	2	32675279
Pubmed	Putative complement control protein CSMD3 dysfunction impairs synaptogenesis and induces neurodevelopmental disorders.	LAMC3 GRIN2A	1.65e-03	22	95	2	35245678
Pubmed	Endodermal Hedgehog signals modulate Notch pathway activity in the developing digestive tract mesenchyme.	TP63 NOTCH2	1.65e-03	22	95	2	21750033
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	XRN1 NAV1 ZNF318 NOTCH2	1.66e-03	184	95	4	32908313
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	GLYR1 ZNF423 ZNF644 ZNF451 ARID5B PLAGL2 ZNF318 ZNF646	1.69e-03	808	95	8	20412781
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	PI4KA NFKBIL1 SMU1 PEX1 LMTK2	1.71e-03	313	95	5	38270169
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ATRN TANC1 MTUS2	1.77e-03	87	95	3	12465718
Pubmed	Aberrant epidermal differentiation and disrupted ΔNp63/Notch regulatory axis in Ets1 transgenic mice.	TP63 NOTCH2	1.80e-03	23	95	2	24337118
Pubmed	ASH2L Mediates Epidermal Differentiation and Hair Follicle Morphogenesis through H3K4me3 Modification.	TP63 NOTCH2	1.80e-03	23	95	2	38582368
Pubmed	Mycn deficiency underlies the development of orofacial clefts in mice and humans.	MYOG TP63	1.96e-03	24	95	2	34590686
Pubmed	p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate.	COL7A1 TP63	1.96e-03	24	95	2	28604778
Pubmed	An approach based on a genome-wide association study reveals candidate loci for narcolepsy.	SCARB1 OR10K1 GRIN2A AKAP1	1.97e-03	193	95	4	20677014
Pubmed	Risk of meningomyelocele mediated by the common 22q11.2 deletion.	MYOG PI4KA	2.13e-03	25	95	2	38696583
Pubmed	PDK1 Is a Regulator of Epidermal Differentiation that Activates and Organizes Asymmetric Cell Division.	TP63 NOTCH2	2.13e-03	25	95	2	27184845
Pubmed	Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death.	PLA2G4F GRIN2A	2.30e-03	26	95	2	9745929
Pubmed	Modulation of the notch signaling by Mash1 and Dlx1/2 regulates sequential specification and differentiation of progenitor cell types in the subcortical telencephalon.	SIX3 NOTCH2	2.30e-03	26	95	2	12397111
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	ANAPC1 PI4KA XRN1 ANKRD30A	2.33e-03	202	95	4	33005030
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	RANBP2 KIAA0319L XRN1 FAM83G COBL TANC1 SIK3 FAM110B	2.36e-03	853	95	8	28718761
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	RANBP2 ANAPC1 PI4KA GLYR1 ZNF644 NISCH ZBTB40 NOTCH2	2.43e-03	857	95	8	25609649
Pubmed	Signalling codes for the maintenance and lineage commitment of embryonic gastric epithelial progenitors.	TP63 NOTCH2	2.48e-03	27	95	2	32878924
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF28 ZNF423 ZNF451 MAZ ZBTB40 PLAGL2 ZNF350 ZNF318 ZNF860 ZNF772 ZNF646	2.45e-05	718	61	11	28
ToppCell	facs-Brain_Non-Myeloid-Striatum\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATRN NISCH SIK3 SIX3 SERPINA9 RYR3	3.65e-06	193	95	6	d8ccfb780a75bdf9141f41fb29a076958601ebb4
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(CH25H+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL7A1 DDHD1 TAFA1 NKX2-3 PTCH2 RYR3	4.11e-06	197	95	6	467e7cbf511d3bcc701923603032aaf0bba2736d
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NKX2-3 COBL LAMC3 CREB3L1 MTUS2 FAM110B	4.35e-06	199	95	6	a95aa72387c9558e0316898eaa9df4de8932af1b
Drug	Propantheline bromide [50-34-0]; Up 200; 9uM; PC3; HT_HG-U133A	LUZP4 ATN1 GLYR1 TP63 SCARB1 MAZ HRC SIX3	1.81e-06	198	95	8	4214_UP
Drug	Mebendazole [31431-39-7]; Down 200; 13.6uM; PC3; HT_HG-U133A	ATRN ATN1 GLYR1 SCARB1 LAMC3 ZNF350 PRR14L	1.72e-05	194	95	7	3671_DN
Drug	Flecainide acetate [54143-56-5]; Down 200; 8.4uM; PC3; HT_HG-U133A	SERPINA1 ATN1 CSRNP3 NBEAL2 COX6A2 CREB3L1 NOTCH2	1.96e-05	198	95	7	3761_DN
Drug	trifluoperazine dihydrochloride; Down 200; 10uM; HL60; HT_HG-U133A	PRSS12 GLYR1 KIAA0319L ZBTB40 PEX1 ZNF350 NOTCH2	1.96e-05	198	95	7	6183_DN
Drug	Gelsemine [509-15-9]; Up 200; 12.4uM; MCF7; HT_HG-U133A	LUZP4 COL7A1 PRSS12 TP63 APBA1 GRIN2A SIX3	2.02e-05	199	95	7	4177_UP
Drug	Zidovudine, AZT [30516-87-1]; Up 200; 15uM; MCF7; HT_HG-U133A	SERPINA1 ATN1 GLYR1 SCARB1 COX6A2 KIAA0319L PLAGL2	2.02e-05	199	95	7	5333_UP
Disease	Malignant neoplasm of breast	COL7A1 SLC39A12 TFAP2D ZNF644 NISCH ANKRD30A CASP7 ZNF318 HSD11B1 SIK3 NOTCH2 ZNF646	9.14e-05	1074	89	12	C0006142
Disease	kallistatin measurement	SERPINA1 SERPINA9	2.49e-04	8	89	2	EFO_0008196
Disease	Colorectal Carcinoma	COL7A1 CSRNP3 SCG5 TP63 C2CD6 GRIN2A ALDH1L1 TLR9 FAM110B	2.71e-04	702	89	9	C0009402
Disease	femoral neck bone mineral density	MALRD1 CSRNP3 ANAPC1 ZNF423 ZBTB40	3.25e-04	196	89	5	EFO_0007785
Disease	cortical thickness	SERPINA1 MALRD1 PRSS12 PI4KA GLYR1 ZNF423 NAV1 LAMC3 C1GALT1 ZNF318 USP35	5.19e-04	1113	89	11	EFO_0004840
Disease	Tinnitus	ARID5B APBA1 ZNF318 THAP12	6.58e-04	130	89	4	HP_0000360
Disease	natural cytotoxicity triggering receptor 3 measurement	NFKBIL1 NCR3	8.00e-04	14	89	2	EFO_0008243
Disease	Gastro-enteropancreatic neuroendocrine tumor	SERPINA1 NOTCH2	9.21e-04	15	89	2	C2930967
Disease	alcohol consumption measurement	SERPINA1 SLC39A12 TFAP2D TAFA1 ARID5B XRN1 SMU1 COBL LAMC3 SIX3 CREB3L1	1.27e-03	1242	89	11	EFO_0007878
Disease	Manic Disorder	SERPINA1 DIXDC1 GRIN2A	1.31e-03	71	89	3	C0024713
Disease	attention deficit hyperactivity disorder, autism spectrum disorder, intelligence	TFAP2D CSRNP3 FSCN3 NAV1 GRIN2A AFG1L	1.31e-03	398	89	6	EFO_0003756, EFO_0003888, EFO_0004337
Disease	protein Z-dependent protease inhibitor measurement	SERPINA1 SERPINA9	1.33e-03	18	89	2	EFO_0021849
Disease	triglyceride measurement, high density lipoprotein cholesterol measurement	SERPINA1 MALRD1 SCARB1 SIK3 SERPINA9	1.46e-03	274	89	5	EFO_0004530, EFO_0004612
Disease	hepatitis B virus infection	GRIN2A AFG1L	1.49e-03	19	89	2	EFO_0004197
Disease	Manic	SERPINA1 DIXDC1 GRIN2A	1.71e-03	78	89	3	C0338831
Disease	serum gamma-glutamyl transferase measurement	ATRN SERPINA1 CSNK1G3 NBEAL2 NKX2-3 LMTK2 NOTCH2 FAM110B AFG1L	1.76e-03	914	89	9	EFO_0004532
Disease	Depression, Bipolar	SERPINA1 DIXDC1 GRIN2A	1.78e-03	79	89	3	C0005587
Disease	bone density, lean body mass	CSRNP3 ZBTB40	1.82e-03	21	89	2	EFO_0003923, EFO_0004995
Disease	Rheumatoid Arthritis	NFKBIL1 ARID5B TNFAIP3 HSD11B1	1.93e-03	174	89	4	C0003873
Disease	smoking status measurement	TFAP2D CSRNP3 ZNF423 ARID5B XRN1 LMTK2 LAMC3 DIXDC1 GRIN2A CDH12	2.59e-03	1160	89	10	EFO_0006527
Disease	cardiovascular disease	TFAP2D ARID5B NAV1 C1GALT1 ZNF318 FAM110B	2.63e-03	457	89	6	EFO_0000319

Protein segments in the cluster

Peptide	Gene	Start	Entry
QQHTHPTFHALRSLD	AKAP1	726	Q92667
LNNAHFPEHLDHFTE	CREB3L1	31	Q96BA8
QRPRDHLQHDHLDST	CREB3L1	461	Q96BA8
LLNEAGHAFTDDHLH	ACTL7B	236	Q9Y614
ESHHPRLASALQDHD	ANKRD30B	1176	Q9BXX2
DTSHHDQDHPTFNKI	SERPINA1	36	P01009
RSLRNSFSGHDPQHH	DIXDC1	521	Q155Q3
CSFVHLNHPLHISDR	FAM106A	31	Q4KMX7
LHLHQQDAIHAASAS	ATN1	1061	P54259
PISSLFLHQHHDSEL	AFG1L	411	Q8WV93
ESHHPRLASAVQDHD	ANKRD30A	1196	Q9BXX3
SREFQLHQHLFDPEH	SCG5	141	P05408
ITNTSLNLFHDDIHH	HSD11B1	121	P28845
LHQRLSEFPHFRNNH	CASP8AP2	136	Q9UKL3
HHGEPTDFINLHNAR	TFAP2D	106	Q7Z6R9
SEPENRTHFHKEFHQ	MTUS2	66	Q5JR59
FHHLPHETSRLETNA	RANBP2	461	P49792
PENDFKHHRSQNHSR	NSRP1	276	Q9H0G5
AHSVHDHQASLDPRS	CYP2F1	246	P24903
GQPEENHHSERSRNH	LUZP4	151	Q9P127
HFPAHSTDNRYHLQA	ANAPC1	1591	Q9H1A4
APVHAQHALSFSNLH	NOTCH2	2191	Q04721
FDSVLNDSLHHSHRH	PRSS12	21	P56730
SARDGDPTFHTHQLH	KIAA0100	1436	Q14667
ASSRFLHDHQAELHI	NCR3	81	O14931
LNHSDHHPILFLSNL	KIAA0319L	741	Q8IZA0
PDLHHDVNRFGHSAV	ATRN	606	O75882
DIHNHARHSARPYTA	C2CD6	561	Q53TS8
EHRSNHPQVEFHSYL	CSRNP3	521	Q8WYN3
KDADPHFHHFLLSQT	GLYR1	211	Q49A26
DLHSALDRSHPQHYT	PI4KA	1176	P42356
FSRPDHLNSHVRQVH	MAZ	346	P56270
HNKPFSEDHHSHRRL	LMTK2	926	Q8IWU2
QFPHSLHLHSNLAAV	TUBGCP5	231	Q96RT8
PAHQDRHGDTALHAA	NFKBIL1	91	Q9UBC1
HKHTFPLNHQDSQEL	PLA2G4F	141	Q68DD2
AILHSLVSENHDNAH	RALGAPA2	1396	Q2PPJ7
DSQQANPHHLRAHLA	CSNK1G3	371	Q9Y6M4
SQEPDTHAVHHRRSQ	NKD2	286	Q969F2
DHQPLLRLSCSDTHH	OR1K1	181	Q8NGR3
FDLTSHLNNPHSRHR	THAP12	86	O43422
LNNGEHHFPAADHTA	MALRD1	501	Q5VYJ5
ILDHRQLHEFSSPSH	TP63	601	Q9H3D4
PAAHARSASHFSLEH	CACNA1G	1911	O43497
DGNHTLFHNSHVNPL	COX6A2	76	Q02221
DPHTFNHQNLTHCSR	CRTC2	596	Q53ET0
NHLNPSHHALEIRSS	COBL	96	O75128
HHFLSHVDRLFSQPS	FSCN3	196	Q9NQT6
LPNHLHFHSLEHEEA	APBA1	146	Q02410
HKAQVPGHSDDHRFQ	CCDC78	131	A2IDD5
RHFESQSDDPHFHEK	CASP7	271	P55210
PHRSEATDLHRHSFA	FAM110B	146	Q8TC76
VLHNDPHARHSDDNG	C1GALT1	41	Q9NS00
PHARHSDDNGQNHLE	C1GALT1	46	Q9NS00
SNLHLDHRFHSAGPF	CDH12	351	P55289
VFLPHATQDNAHRAE	COL7A1	1056	Q02388
TDDHNHHLALDPCLS	DDHD1	71	Q8NEL9
HSHHLALNSELSDQA	SLC39A12	486	Q504Y0
HLQADLEHHFHSAPC	NKX2-3	31	Q8TAU0
HEHSPDAVQSQRLAH	PEX1	676	O43933
EDEHPQCLNSHSHAR	LILRA3	161	Q8N6C8
ACHPHENSSDRHLPL	PRR14L	1311	Q5THK1
SLVFHLPFHSSNQLH	OR10K1	161	Q8NGX5
QQFHHHRVPASGTRD	FAM83G	696	A6ND36
HPAPHTRLFHANEEE	NAV1	1286	Q8NEY1
SLQHTFQQHHLHRPE	TAFA1	26	Q7Z5A9
HHFDPHLEASALRDN	NBEAL2	1846	Q6ZNJ1
NHHSRQAPNVAHELS	PTCH2	266	Q9Y6C5
SSHFLLPNFADSHHR	SIX3	11	O95343
DQAHLHPHLFSDQSR	SIK3	886	Q9Y2K2
LHPNQEAHSLFLDIH	SCARB1	361	Q8WTV0
PHISNEAHRSHLTAA	TANC1	1836	Q9C0D5
HLSEPRFLHLHNDSI	OCSTAMP	526	Q9BR26
HLPSHRSHSHQDEDE	HRC	151	P23327
SAELGHQAPSHRQSH	HRC	431	P23327
HQAPSHRQSHQDEET	HRC	436	P23327
DHLRNHLQTHDPNKE	PLAGL2	111	Q9UPG8
PESAIHQGFQHLVHS	SERPINA9	106	Q86WD7
DRDTDHGPQNHHAHL	ALDH1L1	741	O75891
ENSSFPSHRHQEKLH	ARID5B	866	Q14865
KAFHDPESAQQHFHR	ZNF451	796	Q9Y4E5
ERCHNARQLHASHAP	TNFAIP3	496	P21580
AHHPHQNLIATYSED	SMU1	491	Q2TAY7
SSNRIHHLHDSDFAH	TLR9	71	Q9NR96
HHLHDSDFAHLPSLR	TLR9	76	Q9NR96
HGFETHTLQEHNLAN	RYR3	4806	Q15413
TFQHSHEAFHLLLPH	USP35	336	Q9P2H5
HEFHADLRSCFAPQH	NISCH	801	Q9Y2I1
EFDSLPALRSHFQNH	ZNF646	856	O15015
HQCSHPNDDDVHFRI	XRN1	41	Q8IZH2
GDSFLHANHERLHTA	ZNF350	161	Q9GZX5
SNNFLHEIHDPQHLE	ZNF644	926	Q9H582
GLSFHSHLPELHIFQ	ZNF28	141	P17035
GLSFHSHLPELHIFQ	ZNF860	156	A6NHJ4
DENTLLAHIHQAHAN	ZNF423	306	Q2M1K9
HLDSHRQPDSSNHSV	ZNF423	341	Q2M1K9
FLASSSIFEHHAPHN	ZNF772	231	Q68DY9
SDPHRLESREAHHSN	ZNF318	671	Q5VUA4
RTHHPDVFAAQNHRS	ZBTB40	1026	Q9NUA8
DPQRHHNASYLTDFH	LAMC3	81	Q9Y6N6
HLLTADPTDAHNLHS	MYOG	186	P15173
HTSDNPFLHSHRDDQ	GRIN2A	1361	Q12879