Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	LAM_G_DOMAIN	EYS CELSR1 CELSR2 CNTNAP4	1.15e-04	38	124	4	PS50025
Domain	ALMS_motif	C10orf90 ALMS1	1.31e-04	3	124	2	IPR029299
Domain	ALMS_motif	C10orf90 ALMS1	1.31e-04	3	124	2	PF15309
Domain	Laminin_G_2	EYS CELSR1 CELSR2 CNTNAP4	1.41e-04	40	124	4	PF02210
Domain	EGF	NID2 EYS CELSR1 CELSR2 CNTNAP4 PLAT	1.95e-04	126	124	6	PF00008
Domain	LamG	EYS CELSR1 CELSR2 CNTNAP4	2.05e-04	44	124	4	SM00282
Domain	Glyco_hydro_31_CS	MGAM GANAB	2.60e-04	4	124	2	IPR030459
Domain	MeTrfase	METTL2A METTL2B	2.60e-04	4	124	2	IPR026113
Domain	GLYCOSYL_HYDROL_F31_2	MGAM GANAB	4.32e-04	5	124	2	PS00707
Domain	Mtc	SFXN1 SFXN3	4.32e-04	5	124	2	PF03820
Domain	Mtc	SFXN1 SFXN3	4.32e-04	5	124	2	IPR004686
Domain	Laminin_G	EYS CELSR1 CELSR2 CNTNAP4	5.95e-04	58	124	4	IPR001791
Domain	Glyco_hydro_31_AS	MGAM GANAB	6.45e-04	6	124	2	IPR030458
Domain	Methyltransf_12	METTL2A METTL2B	6.45e-04	6	124	2	IPR013217
Domain	Methyltransf_12	METTL2A METTL2B	6.45e-04	6	124	2	PF08242
Domain	fn3	EPHB6 EPOR LRFN1 LRFN3 PTPRU TYRO3	7.46e-04	162	124	6	PF00041
Domain	Glyco_hydro_31	MGAM GANAB	8.98e-04	7	124	2	IPR000322
Domain	Glyco_hydro_31	MGAM GANAB	8.98e-04	7	124	2	PF01055
Domain	GLYCOSYL_HYDROL_F31_1	MGAM GANAB	8.98e-04	7	124	2	PS00129
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	COL6A2 ARHGEF5 MYO19 SREBF1 SREBF2 PFAS NOL9 FREM2 TMEM62 TRMT2A UPF2 TSR1 BUB1B SLTM	1.36e-07	650	128	14	38777146
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DAB2IP ERCC2 LRFN1 SH2B3 KSR2 SREBF1 PFAS PIGG KMT2C TMEM129 CELSR1 INTS5 CELSR2 TTLL4 HELZ2 DYNC1H1 CYB5R2	6.78e-07	1105	128	17	35748872
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	DLG5 ERCC2 RGS19 PUSL1 EPB41L5 PIGG NOL9 TMEM205 TAF6L KMT2C CELSR1 INTS5 SPATS2L TSR1 HELZ2 RBM6 CTNNA2 KIF22	9.84e-06	1497	128	18	31527615
Pubmed	Sterol regulatory element-binding proteins are regulators of the sodium/iodide symporter in mammary epithelial cells.	SREBF1 SREBF2	1.34e-05	2	128	2	27614840
Pubmed	Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane.	SREBF1 SREBF2	1.34e-05	2	128	2	8626610
Pubmed	Role of altered renal lipid metabolism and the sterol regulatory element binding proteins in the pathogenesis of age-related renal disease.	SREBF1 SREBF2	1.34e-05	2	128	2	16316337
Pubmed	Effects of a catechin-free fraction derived from green tea on gene expression of enzymes related to lipid metabolism in the mouse liver.	SREBF1 SREBF2	1.34e-05	2	128	2	22361881
Pubmed	Impaired regulation of sterol regulatory element binding protein 2 in cholesterol gallstone-susceptible mice.	SREBF1 SREBF2	1.34e-05	2	128	2	15062879
Pubmed	The LIM-homeodomain gene family in the developing Xenopus brain: conservation and divergences with the mouse related to the evolution of the forebrain.	LHX1 LHX5	1.34e-05	2	128	2	11567052
Pubmed	Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes.	SREBF1 SREBF2	1.34e-05	2	128	2	12177166
Pubmed	Association of sterol regulatory element-binding transcription factor gene polymorphisms with ischaemic stroke.	SREBF1 SREBF2	1.34e-05	2	128	2	22429355
Pubmed	Expression of Sterol Regulatory Element-Binding Proteins in epicardial adipose tissue in patients with coronary artery disease and diabetes mellitus: preliminary study.	SREBF1 SREBF2	1.34e-05	2	128	2	28367087
Pubmed	SREBP-1c gene polymorphism is associated with increased inhibition of cholesterol-absorption in response to ezetimibe treatment.	SREBF1 SREBF2	1.34e-05	2	128	2	18072016
Pubmed	Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model.	SREBF1 SREBF2	1.34e-05	2	128	2	16879892
Pubmed	Spatial distribution and function of sterol regulatory element-binding protein 1a and 2 homo- and heterodimers by in vivo two-photon imaging and spectroscopy fluorescence resonance energy transfer.	SREBF1 SREBF2	1.34e-05	2	128	2	15798184
Pubmed	SREBP transcription factors: master regulators of lipid homeostasis.	SREBF1 SREBF2	1.34e-05	2	128	2	15589694
Pubmed	Transcriptional regulation of phagocytosis-induced membrane biogenesis by sterol regulatory element binding proteins.	SREBF1 SREBF2	1.34e-05	2	128	2	16141315
Pubmed	Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes.	SREBF1 SREBF2	1.34e-05	2	128	2	10585467
Pubmed	Determinants of variable response to simvastatin treatment: the role of common variants of SCAP, SREBF-1a and SREBF-2 genes.	SREBF1 SREBF2	1.34e-05	2	128	2	16158080
Pubmed	Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13.	SREBF1 SREBF2	1.34e-05	2	128	2	7759101
Pubmed	Drosophila ATP6AP2/VhaPRR functions both as a novel planar cell polarity core protein and a regulator of endosomal trafficking.	CELSR1 CELSR2	1.34e-05	2	128	2	23292348
Pubmed	Selective binding of sterol regulatory element-binding protein isoforms and co-regulatory proteins to promoters for lipid metabolic genes in liver.	SREBF1 SREBF2	1.34e-05	2	128	2	18413311
Pubmed	Dysregulation of sterol response element-binding proteins and downstream effectors in prostate cancer during progression to androgen independence.	SREBF1 SREBF2	1.34e-05	2	128	2	15026365
Pubmed	Role for sterol regulatory element-binding protein in activation of endothelial cells by phospholipid oxidation products.	SREBF1 SREBF2	1.34e-05	2	128	2	15388640
Pubmed	The potential role of sterol regulatory element binding protein transcription factors in renal injury.	SREBF1 SREBF2	1.34e-05	2	128	2	17198935
Pubmed	Polymorphisms in SREBF1 and SREBF2, two antipsychotic-activated transcription factors controlling cellular lipogenesis, are associated with schizophrenia in German and Scandinavian samples.	SREBF1 SREBF2	1.34e-05	2	128	2	18936756
Pubmed	Downregulation of SREBP inhibits tumor growth and initiation by altering cellular metabolism in colon cancer.	SREBF1 SREBF2	1.34e-05	2	128	2	29449559
Pubmed	SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene.	SREBF1 SREBF2	1.34e-05	2	128	2	8402897
Pubmed	SREBF1c and SREBF2 gene polymorphisms are associated with acute coronary syndrome and blood lipid levels in Mexican population.	SREBF1 SREBF2	1.34e-05	2	128	2	31490983
Pubmed	Expanding roles for SREBP in metabolism.	SREBF1 SREBF2	1.34e-05	2	128	2	23000402
Pubmed	CREating a SCAP-less liver keeps SREBPs pinned in the ER membrane and prevents increased lipid synthesis in response to low cholesterol and high insulin.	SREBF1 SREBF2	1.34e-05	2	128	2	11485982
Pubmed	SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.	SREBF1 SREBF2	1.34e-05	2	128	2	7903453
Pubmed	Sterol-dependent regulation of proprotein convertase subtilisin/kexin type 9 expression by sterol-regulatory element binding protein-2.	SREBF1 SREBF2	1.34e-05	2	128	2	17921436
Pubmed	Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.	SREBF1 SREBF2	1.34e-05	2	128	2	9329978
Pubmed	Regulation of the ADMA-DDAH system in endothelial cells: a novel mechanism for the sterol response element binding proteins, SREBP1c and -2.	SREBF1 SREBF2	1.34e-05	2	128	2	19915177
Pubmed	Structure of the human gene encoding sterol regulatory element binding protein 2 (SREBF2).	SREBF1 SREBF2	1.34e-05	2	128	2	9070916
Pubmed	Diet-induced obesity in C57BL/6J mice causes increased renal lipid accumulation and glomerulosclerosis via a sterol regulatory element-binding protein-1c-dependent pathway.	SREBF1 SREBF2	1.34e-05	2	128	2	16046411
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	BRSK2 EPB41L5 PFAS TRAPPC8 PTGFRN POM121 ALMS1 HELZ2 CNTNAP4 SLX4	1.53e-05	493	128	10	15368895
Pubmed	Defects in translation-dependent quality control pathways lead to convergent molecular and neurodevelopmental pathology.	LHX1 UPF2 LHX5	2.14e-05	15	128	3	33899734
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	EPHB6 ZBTB22 LCA5L PTPRU TYRO3 EYS RLIM HTATSF1 TAB1	2.70e-05	420	128	9	28065597
Pubmed	Primary Familial and Congenital Polycythemia	EPOR SH2B3	4.02e-05	3	128	2	27831681
Pubmed	Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy status.	SREBF1 SREBF2	4.02e-05	3	128	2	11739104
Pubmed	Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs.	SREBF1 SREBF2	4.02e-05	3	128	2	12032166
Pubmed	A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies.	SREBF1 SREBF2	4.02e-05	3	128	2	11929849
Pubmed	Anti-cancer efficacy of SREBP inhibitor, alone or in combination with docetaxel, in prostate cancer harboring p53 mutations.	SREBF1 SREBF2	4.02e-05	3	128	2	26512780
Pubmed	Growth factor-induced phosphorylation of sterol regulatory element-binding proteins inhibits sumoylation, thereby stimulating the expression of their target genes, low density lipoprotein uptake, and lipid synthesis.	SREBF1 SREBF2	4.02e-05	3	128	2	18403372
Pubmed	Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP.	SREBF1 SREBF2	4.02e-05	3	128	2	26028026
Pubmed	Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes.	SREBF1 SREBF2	4.02e-05	3	128	2	14512514
Pubmed	Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi.	SREBF1 SREBF2	4.02e-05	3	128	2	10619424
Pubmed	A functional interaction between Hippo-YAP signalling and SREBPs mediates hepatic steatosis in diabetic mice.	SREBF1 SREBF2	4.02e-05	3	128	2	30821074
Pubmed	Synaptic adhesion-like molecules (SALMs) promote neurite outgrowth.	LRFN1 LRFN3	4.02e-05	3	128	2	18585462
Pubmed	The Niemann-Pick C1 gene is downregulated by feedback inhibition of the SREBP pathway in human fibroblasts.	SREBF1 SREBF2	4.02e-05	3	128	2	18272927
Pubmed	Similarities and differences in the forebrain expression of Lhx1 and Lhx5 between chicken and mouse: Insights for understanding telencephalic development and evolution.	LHX1 LHX5	4.02e-05	3	128	2	20589911
Pubmed	Centriolar association of ALMS1 and likely centrosomal functions of the ALMS motif-containing proteins C10orf90 and KIAA1731.	C10orf90 ALMS1	4.02e-05	3	128	2	20844083
Pubmed	A novel functional interaction between the Sp1-like protein KLF13 and SREBP-Sp1 activation complex underlies regulation of low density lipoprotein receptor promoter function.	SREBF1 SREBF2	4.02e-05	3	128	2	16303770
Pubmed	Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein.	SREBF1 SREBF2	4.02e-05	3	128	2	9242699
Pubmed	The flamingo-related mouse Celsr family (Celsr1-3) genes exhibit distinct patterns of expression during embryonic development.	CELSR1 CELSR2	4.02e-05	3	128	2	11677057
Pubmed	Human caspase 7 is positively controlled by SREBP-1 and SREBP-2.	SREBF1 SREBF2	4.02e-05	3	128	2	19323650
Pubmed	Activation of sterol regulatory element binding protein and NLRP3 inflammasome in atherosclerotic lesion development in diabetic pigs.	SREBF1 SREBF2	4.02e-05	3	128	2	23825667
Pubmed	Lipid deprivation increases surfactant phosphatidylcholine synthesis via a sterol-sensitive regulatory element within the CTP:phosphocholine cytidylyltransferase promoter.	SREBF1 SREBF2	4.02e-05	3	128	2	11829742
Pubmed	Lhx1/5 control dendritogenesis and spine morphogenesis of Purkinje cells via regulation of Espin.	LHX1 LHX5	4.02e-05	3	128	2	28516904
Pubmed	Resveratrol increases the expression and activity of the low density lipoprotein receptor in hepatocytes by the proteolytic activation of the sterol regulatory element-binding proteins.	SREBF1 SREBF2	4.02e-05	3	128	2	22153697
Pubmed	Mutant huntingtin interacts with the sterol regulatory element-binding proteins and impairs their nuclear import.	SREBF1 SREBF2	4.02e-05	3	128	2	31875875
Pubmed	Sterol regulatory element-binding proteins are regulators of the NIS gene in thyroid cells.	SREBF1 SREBF2	4.02e-05	3	128	2	23542164
Pubmed	[Genetic predisposition to ischemic heart disease in patients with obstructive sleep apnea syndrome (OSAS)].	SREBF1 SREBF2	4.02e-05	3	128	2	24868893
Pubmed	Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP.	SREBF1 SREBF2	4.02e-05	3	128	2	30718857
Pubmed	Identification and validation of seven new loci showing differential DNA methylation related to serum lipid profile: an epigenome-wide approach. The REGICOR study.	SREBF1 SREBF2	4.02e-05	3	128	2	28173150
Pubmed	Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis.	SREBF1 SREBF2	4.02e-05	3	128	2	15085196
Pubmed	Identification of human ELOVL5 enhancer regions controlled by SREBP.	SREBF1 SREBF2	4.02e-05	3	128	2	26321664
Pubmed	Selective role of sterol regulatory element binding protein isoforms in aggregated LDL-induced vascular low density lipoprotein receptor-related protein-1 expression.	SREBF1 SREBF2	4.02e-05	3	128	2	20980003
Pubmed	DALRD3 encodes a protein mutated in epileptic encephalopathy that targets arginine tRNAs for 3-methylcytosine modification.	METTL2A METTL2B	4.02e-05	3	128	2	32427860
Pubmed	Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity.	SREBF1 SREBF2	4.02e-05	3	128	2	23563690
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	DAB2IP DPAGT1 HJURP SREBF2 NOL9 TGM4 KMT2C TSR1 TTLL4 RLIM SFXN3 SLTM TNS1 SLX4	4.83e-05	1084	128	14	11544199
Pubmed	TRIM65 regulates microRNA activity by ubiquitination of TNRC6.	HJURP PFAS NOL9 TAF6L TRMT2A ALMS1 UPF2 TSR1	6.40e-05	364	128	8	24778252
Pubmed	MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis.	SREBF1 SREBF2	8.02e-05	4	128	2	20466882
Pubmed	Urokinase activates macrophage PON2 gene transcription via the PI3K/ROS/MEK/SREBP-2 signalling cascade mediated by the PDGFR-beta.	SREBF2 PON2	8.02e-05	4	128	2	19497963
Pubmed	Sterol response element binding protein and thyroid transcription factor-1 (Nkx2.1) regulate Abca3 gene expression.	SREBF1 SREBF2	8.02e-05	4	128	2	17890326
Pubmed	Peroxisome deficiency causes a complex phenotype because of hepatic SREBP/Insig dysregulation associated with endoplasmic reticulum stress.	SREBF1 SREBF2	8.02e-05	4	128	2	19110480
Pubmed	Sterol regulatory element binding proteins (SREBP)-1a and SREBP-2 are linked to the MAP-kinase cascade.	SREBF1 SREBF2	8.02e-05	4	128	2	10627507
Pubmed	Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice.	SREBF1 SREBF2	8.02e-05	4	128	2	28244871
Pubmed	Srebp-controlled glucose metabolism is essential for NK cell functional responses.	SREBF1 SREBF2	8.02e-05	4	128	2	28920951
Pubmed	Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice.	SREBF1 SREBF2	8.02e-05	4	128	2	16890542
Pubmed	Interaction between sterol regulatory element-binding proteins and liver receptor homolog-1 reciprocally suppresses their transcriptional activities.	SREBF1 SREBF2	8.02e-05	4	128	2	17283069
Pubmed	Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways.	EPOR SH2B3	8.02e-05	4	128	2	15705783
Pubmed	Coordinate roles for LIM homeobox genes in directing the dorsoventral trajectory of motor axons in the vertebrate limb.	LHX1 LHX5	8.02e-05	4	128	2	10943837
Pubmed	HCBP6 Modulates Triglyceride Homeostasis in Hepatocytes Via the SREBP1c/FASN Pathway.	SREBF1 FUNDC2	8.02e-05	4	128	2	25855506
Pubmed	The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via distinct activation mechanisms.	CELSR1 CELSR2	8.02e-05	4	128	2	37224017
Pubmed	Mutually exclusive substrate selection strategy by human m3C RNA transferases METTL2A and METTL6.	METTL2A METTL2B	8.02e-05	4	128	2	34268557
Pubmed	SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein.	SREBF1 SREBF2	8.02e-05	4	128	2	8918891
Pubmed	mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.	SREBF1 SREBF2	8.02e-05	4	128	2	21816276
Pubmed	Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER.	SREBF1 SREBF2	8.02e-05	4	128	2	12202038
Pubmed	Developmental expression profiles of Celsr (Flamingo) genes in the mouse.	CELSR1 CELSR2	8.02e-05	4	128	2	11850187
Pubmed	Sterol regulatory element-binding proteins are negatively regulated through SUMO-1 modification independent of the ubiquitin/26 S proteasome pathway.	SREBF1 SREBF2	8.02e-05	4	128	2	12615929
Pubmed	Identification of a novel family of putative methyltransferases that interact with human and Drosophila presenilins.	METTL2A METTL2B	8.02e-05	4	128	2	11738826
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	ERCC2 PPP1R3E XNDC1N TMEM9B PTGFRN TMEM129 GANAB TSR1 ELFN1 ETHE1 HES7 RBM6 ALDH3B1	1.05e-04	1021	128	13	26760575
Pubmed	Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling.	FREM2 CELSR1 CELSR2 DYNC1H1	1.12e-04	67	128	4	21875946
Pubmed	The impact of severe LDL receptor mutations on SREBP-pathway regulation in homozygous familial hypercholesterolemia (FH).	SREBF1 SREBF2	1.33e-04	5	128	2	22425645
Pubmed	Methyl protodioscin increases ABCA1 expression and cholesterol efflux while inhibiting gene expressions for synthesis of cholesterol and triglycerides by suppressing SREBP transcription and microRNA 33a/b levels.	SREBF1 SREBF2	1.33e-04	5	128	2	25733328
Pubmed	Homeodomain transcription factors in the development of subsets of hindbrain reticulospinal neurons.	LHX1 LHX5	1.33e-04	5	128	2	15607939
Pubmed	Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects?	SREBF1 SREBF2	1.33e-04	5	128	2	18195716
Interaction	NXPH3 interactions	COL6A2 PTPRU CELSR1 CELSR2 TAB1 CTNNA2	1.64e-06	58	126	6	int:NXPH3
Cytoband	11q12.3	TAF6L INTS5 GANAB	1.66e-04	38	128	3	11q12.3
Cytoband	19p13.2	ZNF627 RNASEH2A TMEM205 ZNF20 ZNF791	4.75e-04	229	128	5	19p13.2
Cytoband	15q15	TYRO3 BUB1B	5.00e-04	12	128	2	15q15
GeneFamily	Fibronectin type III domain containing	EPHB6 EPOR LRFN1 LRFN3 PTPRU TYRO3 ELFN1	4.88e-06	160	76	7	555
GeneFamily	Adhesion G protein-coupled receptors, subfamily C\|CELSR cadherins	CELSR1 CELSR2	5.22e-05	3	76	2	913
GeneFamily	Adhesion G protein-coupled receptors, subfamily C\|CELSR cadherins	CELSR1 CELSR2	5.22e-05	3	76	2	1189
GeneFamily	Sideroflexins	SFXN1 SFXN3	1.73e-04	5	76	2	746
GeneFamily	LIM class homeoboxes	LHX1 LHX5	1.12e-03	12	76	2	522
GeneFamily	Glycosyl transferases group 1 domain containing\|Phosphatidylinositol glycan anchor biosynthesis	PIGG PIGQ	3.48e-03	21	76	2	680
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)\|390C / Donor, Lineage, Cell class and subclass (all cells)	DAB2IP ARHGEF5 BCLAF3 PIGQ CELSR1 RBM6 TAB1	1.51e-06	194	128	7	88db9f9e80c20ff3474f1f6459dcbdc25aec0b6d
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	DAB2IP ARHGEF5 BCLAF3 PIGQ CELSR1 RBM6 TAB1	1.51e-06	194	128	7	a71728202493d4858342ea2756ea281cd0d99a3a
Disease	Pulmonary Thromboembolisms	DAB2IP CAT PLAT	1.44e-05	12	121	3	C0524702
Disease	Pulmonary Embolism	DAB2IP CAT PLAT	1.44e-05	12	121	3	C0034065
Disease	lipid storage disease (biomarker_via_orthology)	SREBF1 SREBF2	1.67e-05	2	121	2	DOID:9455 (biomarker_via_orthology)
Disease	familial erythrocytosis 1 (is_implicated_in)	EPOR SH2B3	4.99e-05	3	121	2	DOID:0060652 (is_implicated_in)
Disease	ERYTHROCYTOSIS, FAMILIAL, 1	EPOR SH2B3	4.99e-05	3	121	2	133100
Disease	Primary familial polycythemia due to EPO receptor mutation	EPOR SH2B3	4.99e-05	3	121	2	cv:C4551637
Disease	Familial erythrocytosis	EPOR SH2B3	2.47e-04	6	121	2	cv:C0152264
Disease	asphyxia neonatorum (biomarker_via_orthology)	ERCC2 HTRA2	2.47e-04	6	121	2	DOID:11088 (biomarker_via_orthology)
Disease	hereditary lymphedema (is_implicated_in)	THSD1 CELSR1	3.46e-04	7	121	2	DOID:0050580 (is_implicated_in)
Disease	catalase measurement	CAT CELSR2	3.46e-04	7	121	2	EFO_0008071
Disease	vascular dementia (is_implicated_in)	SREBF2 PON2	3.46e-04	7	121	2	DOID:8725 (is_implicated_in)
Disease	tyrosine-protein kinase receptor TYRO3 measurement	MGAM TYRO3	4.59e-04	8	121	2	EFO_0020829
Disease	Erythrocytosis familial, 1	EPOR SH2B3	5.89e-04	9	121	2	C4551637
Disease	Myocardial Infarction	DAB2IP SH2B3 CAT PLAT	6.42e-04	95	121	4	C0027051
Disease	osteonecrosis (is_implicated_in)	CAT PLAT	7.35e-04	10	121	2	DOID:10159 (is_implicated_in)
Disease	urinary albumin to creatinine ratio	MGAM WDR81 TSPY26P TYRO3 SPATS2L	8.75e-04	179	121	5	EFO_0007778
Disease	senile cataract (is_implicated_in)	ERCC2 CAT	8.95e-04	11	121	2	DOID:9669 (is_implicated_in)
Disease	end stage renal disease (biomarker_via_orthology)	EPOR SREBF2 CAT	9.56e-04	47	121	3	DOID:783 (biomarker_via_orthology)
Disease	Kidney Failure, Chronic	SREBF1 SREBF2 CAT	1.02e-03	48	121	3	C0022661
Disease	methionine sulfone measurement	SLC7A7 ALMS1	1.07e-03	12	121	2	EFO_0800072
Disease	xanthine measurement	KSR2 EYS	1.26e-03	13	121	2	EFO_0010548
Disease	Yu-Zhi constitution type	PON2 FREM2	1.69e-03	15	121	2	EFO_0007638
Disease	Disorder of eye	KCNV2 FREM2 EYS ALMS1 FOXE3	1.85e-03	212	121	5	C0015397
Disease	Global developmental delay	ABAT BRSK2 PIGQ CTNNA2	2.23e-03	133	121	4	C0557874
Disease	Hypercholesterolemia, Familial	SREBF2 PON2	2.44e-03	18	121	2	C0020445
Disease	Intellectual Disability	RNASEH2A BRSK2 KMT2C RLIM PISD CTNNA2 DYNC1H1	2.51e-03	447	121	7	C3714756
Disease	Microcephaly	BUB1B PISD DYNC1H1	2.66e-03	67	121	3	C0025958
Disease	stomach cancer (is_implicated_in)	DAB2IP ERCC2 KMT2C	3.26e-03	72	121	3	DOID:10534 (is_implicated_in)
Disease	kidney disease (biomarker_via_orthology)	SREBF1 SREBF2	3.33e-03	21	121	2	DOID:557 (biomarker_via_orthology)
Disease	fumarate measurement	EYS SMTNL2	3.33e-03	21	121	2	EFO_0010480
Disease	status epilepticus (implicated_via_orthology)	ABAT PLAT	3.33e-03	21	121	2	DOID:1824 (implicated_via_orthology)
Disease	pentachlorophenol measurement	EYS SPATS2L TNS1	3.39e-03	73	121	3	EFO_0022071
Disease	parathion measurement	EYS SPATS2L TNS1	3.39e-03	73	121	3	EFO_0022070
Disease	potassium chromate measurement	EYS SPATS2L TNS1	3.39e-03	73	121	3	EFO_0022072
Disease	mercuric chloride measurement	EYS SPATS2L TNS1	3.39e-03	73	121	3	EFO_0022068
Disease	heptachlor epoxide measurement	EYS SPATS2L TNS1	3.39e-03	73	121	3	EFO_0022067
Disease	methoxychlor measurement	EYS SPATS2L TNS1	3.39e-03	73	121	3	EFO_0022069
Disease	4,6-dinitro-o-cresol measurement	EYS SPATS2L TNS1	3.39e-03	73	121	3	EFO_0022053
Disease	2,4,5-trichlorophenol measurement	EYS SPATS2L TNS1	3.39e-03	73	121	3	EFO_0022052
Disease	azinphos methyl measurement	EYS SPATS2L TNS1	3.39e-03	73	121	3	EFO_0022055
Disease	aldrin measurement	EYS SPATS2L TNS1	3.39e-03	73	121	3	EFO_0022054
Disease	dicofol measurement	EYS SPATS2L TNS1	3.39e-03	73	121	3	EFO_0022060
Disease	disulfoton measurement	EYS SPATS2L TNS1	3.39e-03	73	121	3	EFO_0022062
Disease	dieldrin measurement	EYS SPATS2L TNS1	3.39e-03	73	121	3	EFO_0022061
Disease	endrin measurement	EYS SPATS2L TNS1	3.39e-03	73	121	3	EFO_0022064
Disease	endosulfan measurement	EYS SPATS2L TNS1	3.39e-03	73	121	3	EFO_0022063
Disease	heptachlor measurement	EYS SPATS2L TNS1	3.39e-03	73	121	3	EFO_0022066
Disease	ethion measurement	EYS SPATS2L TNS1	3.39e-03	73	121	3	EFO_0022065
Disease	chlorpyrifos measurement	EYS SPATS2L TNS1	3.39e-03	73	121	3	EFO_0022057
Disease	cadmium chloride measurement	EYS SPATS2L TNS1	3.39e-03	73	121	3	EFO_0022056
Disease	diazinon measurement	EYS SPATS2L TNS1	3.39e-03	73	121	3	EFO_0022059
Disease	dibutyl phthalate measurement	EYS SPATS2L TNS1	3.39e-03	73	121	3	EFO_0022058
Disease	environmental exposure measurement	EYS SPATS2L TNS1	3.39e-03	73	121	3	EFO_0008360
Disease	DDT metabolite measurement	EYS SPATS2L TNS1	3.53e-03	74	121	3	EFO_0007886
Disease	progression free survival, ovarian serous carcinoma	MGAM CTNNA2	3.65e-03	22	121	2	EFO_0004920, EFO_1001516
Disease	nephrosis (biomarker_via_orthology)	SREBF2 PTPRU	3.65e-03	22	121	2	DOID:2527 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
ISDIHLSRFRDPGRA	TMEM62	61	Q0P6H9
FARAARFVSTPFHEI	BUB1B	611	O60566
AQHLAFFSRFSARGP	B4GALT2	36	O60909
PSRAAFLTGRHSFRS	ARSD	91	P51689
VRSPRAFRAEAVGVH	ELFN1	646	P0C7U0
VSFLFSDRGIPDGHR	CAT	196	P04040
GDFAPVRVFSRTLHN	CREB3L3	351	Q68CJ9
LREAFHAGRTRPAEF	ALDH3B1	11	P43353
HAGRTRPAEFRAAQL	ALDH3B1	16	P43353
RFLVFDHAPFSSIRG	ARHGEF5	1436	Q12774
LQFHRPDFISRSGER	ALMS1	4041	Q8TCU4
PVHRAFSRIARVGFL	AJM1	731	C9J069
SSSHGPGFARLNRRD	CNTNAP4	51	Q9C0A0
VFLASRAGRLRFHGP	AMN	181	Q9BXJ7
FNFTGARVPRFDTIH	CELSR1	2256	Q9NYQ6
SFPAHSFITFRGLRQ	CELSR2	1371	Q9HCU4
SRPRGHFSPALRREF	CCDC90B	21	Q9GZT6
SPLGALQHGFFRRTA	DYRK1B	421	Q9Y463
RAITRDGTRDHQFPA	HJURP	666	Q8NCD3
EKISHNTRRFRFGLP	CYB5R2	26	Q6BCY4
NLPHRVTRDTAFRGF	CYP2F1	366	P24903
HFAISAAFSANERPR	MSL3P1	141	P0C860
SFRHILPGFRSAAAA	DAB2IP	101	Q5VWQ8
RHRDGRILLFSGPQF	MMP25	376	Q9NPA2
TDFAFRITPRNRESH	NOL9	501	Q5SY16
GDGLLLRSHAASRRF	LDLRAD2	41	Q5SZI1
LRSHAASRRFYFVAP	LDLRAD2	46	Q5SZI1
RGERDHTFRVGSLIF	KMT2C	4541	Q8NEZ4
PHDGRRLAVRFTALD	LRP10	226	Q7Z4F1
SAATLGFFFPDRRAR	EYS	1376	Q5T1H1
ISAAGFPIRVSHRNF	MYO19	651	Q96H55
GALFQSHSYPRRARR	LRFN1	711	Q9P244
LFFRAHSRGDTVARP	MGAM	726	O43451
SERSLRSFFVGHAPF	KSR2	361	Q6VAB6
VRYSHLGARSPSRDR	FREM2	136	Q5SZK8
SIRFRPTLVFRDHHA	ABAT	471	P80404
SIKNSFLGSPRFHRR	BRSK2	481	Q8IWQ3
VTLIPAFRGHFIAAR	DPAGT1	26	Q9H3H5
FERHFLPASRNRTVG	KIF22	221	Q14807
ALARAFPLFTHRSGA	NPEPL1	126	Q8NDH3
FPLFTHRSGASRRLE	NPEPL1	131	Q8NDH3
QRFASKAGIPDRRFH	CSPP1	291	Q1MSJ5
GSRFLSDPARVFHHN	METTL2B	21	Q6P1Q9
RLAFATHGTAFDKRP	DLG5	166	Q8TDM6
GSIRTAEHFLGFLRR	ERCC2	321	P18074
GPLRQRRHYSFTEAT	LCA5L	516	O95447
LSALGARRHAFFRSP	LHX1	241	P48742
LSALGARRHAFFRSP	LHX5	241	Q9H2C1
RHVAAGAFADLRALR	LRFN3	96	Q9BTN0
RPRFAAFTATLHAVG	GPR78	166	Q96P69
GSRFLRDPARVFHHN	METTL2A	21	Q96IZ6
GVRHISHRRFLATFP	PTPRU	236	Q92729
LFDRHPDGVASVSFR	HTATSF1	306	O43719
FPSAAGLHRALLRRV	HERC5	36	Q9UII4
FRRFALPRASVSGFQ	PARD6A	26	Q9NPB6
RAGFPRSARFTPTHA	NID2	141	Q14112
RISRGFDLASFNPHG	PON2	101	Q15165
SFVRKARHRRPLSSF	POM121	81	Q96HA1
AFFRLRGPVQKSSHR	EPB41L5	321	Q9HCM4
FAIPSDRLREFLHRG	HTRA2	331	O43464
SPSHTFRGLLRELRY	FMC1	6	Q96HJ9
RFTGPRGFITHKFRE	BCLAF3	681	A2AJT9
AFLRHPDVAATRANR	CTNNA2	226	P26232
SPRGGARRHAELSFV	COL6A2	931	P12110
RFGRFALETRASPGH	ETHE1	121	O95571
SRFNALFVRPHIRGA	DYNC1H1	586	Q14204
ELRVTAASGAPRYHR	EPOR	121	P19235
PRLFSVARARAAEHT	HELZ2	701	Q9BYK8
LRLAAFAHDASPAAR	HES7	101	Q9BYE0
TARALRAAARHTPLF	B3GNT6	291	Q6ZMB0
GRFLFRSPESHLRTS	UPF2	711	Q9HAU5
TARHSAAYRADPLRV	FUNDC2	16	Q9BWH2
PARRSVLALTHEGRF	PTGFRN	191	Q9P2B2
AIRVLRAFRVPSDFH	PUSL1	106	Q8N0Z8
RAFRVPSDFHARHAA	PUSL1	111	Q8N0Z8
RFAPRGAPHFRFIIA	TAF6L	551	Q9Y6J9
SRLFGFVRLHEDGAR	UTY	51	O14607
DFRDRDTPHSDFRGR	RBM6	246	P78332
DTPHSDFRGRHRSRT	RBM6	251	P78332
HSPAGRSVFRAFLRT	RGS19	96	P49795
PRHASFSDVRRFLGR	TRMT2A	81	Q8IZ69
LGRARHFFTVTDPRN	SFXN3	21	Q9BWM7
FIGRANHFFTVTDPR	SFXN1	21	Q9H9B4
RQHAADTSEARPFRG	SPATS2L	511	Q9NUQ6
FVSGFLLFRSLPRHT	TMEM205	31	Q6UW68
GSQARPRSSHRYFLE	RNASEH2A	276	O75792
PRSSHRYFLERGLES	RNASEH2A	281	O75792
TFASGGERARFCPRH	TAB1	341	Q15750
PLVRVTFHALVRGAF	OVCH1	936	Q7RTY7
GTRFGARSRAHAPSR	PPP1R3E	46	Q9H7J1
PFFRAHAHLDTGRRE	GANAB	671	Q14697
DRARRPHFDQLVAAF	EPHB6	901	O15197
ARHSTGLRAFGFTLR	KCNV2	391	Q8TDN2
FRSDRFDEGPVRLSH	PIGQ	176	Q9BRB3
HAPGRRLTLAAIYRF	FOXE3	86	Q13461
FDHRERGRFPESSAV	SLTM	771	Q9NWH9
AFAALPHDRSLRDAR	SMIM32	81	A0A1B0GUA5
TSSPVFRRGQVFHLR	TGM4	31	P49221
GLVRAGVHRFFASLR	INTS5	646	Q6P9B9
TKAPRGFAFVRFHDR	SRSF8	51	Q9BRL6
PISGDRAHFSRRFLK	SLX4	1361	Q8IY92
RDRASRIFPHLYLGS	SSH3	326	Q8TE77
PRALHFLTRFFLSSA	SREBF1	731	P36956
ADRPFHLSARDAREA	CHST7	416	Q9NS84
PGRHQRSFACTEFSR	C10orf90	186	Q96M02
RVAYRSSHGDLRPRA	C11orf71	16	Q6IPW1
GNAFSFPSEIRRHKR	ZNF20	261	P17024
AAIFAKHRRSPGERF	PLAT	326	P00750
RRFRASPLFSQHTAA	TSR1	621	Q2NL82
SFSARPAFRVHVRVH	ZNF791	336	Q3KP31
PFANAHDVLARSRSR	TMEM9B	151	Q9NQ34
LPFRAFRTDARKIHT	PISD	41	Q9UG56
AAVTFHPRAGAELRR	PFAS	1131	O15067
SGARREGRHRAPVTF	RLIM	506	Q9NVW2
AEDRFRPQSRGAHLF	THSD1	691	Q9NS62
ASRLFFVGSREGHLP	SLC7A7	331	Q9UM01
GSLRRLAHSFRPAYR	SREBF2	1016	Q12772
EPGAFIIRDSHSFRG	TNS1	1481	Q9HBL0
RPRADHLAVFFVFSG	UNC93A	341	Q86WB7
RALSYHRSFPVRERT	ZNF627	146	Q7L945
RARHVAPDSIRGSFG	NME6	106	O75414
RAPRLGSARFASHAT	SMTNL2	111	Q2TAL5
FRRRSAGELPAAHTA	SH2B3	146	Q9UQQ2
PFTRHQSFGLAFLRV	XNDC1N	136	Q6ZNB5
NSSATRVFFGHDRRP	TRAPPC8	671	Q9Y2L5
AAFVPFHLRRTAATL	TMEM129	46	A0AVI4
PEFRTVGALLRSRFH	WNT10A	281	Q9GZT5
ESSGVARFGPLHFER	TMEM134	26	Q9H6X4
GFFPAPVRSSARAEH	PIGG	26	Q5H8A4
PALVHRNRDTVRSFF	TSPY26P	281	Q9H489
EFSRRGQFERIFPSH	TTLL4	1016	Q14679
GEPAVHFRAARSFNR	TYRO3	471	Q06418
REFRAHRAVLAASSP	ZBTB22	66	O15209
VVDFTTPHGRFRDLR	WDR81	386	Q562E7
ARFHLSEDLAGSRRP	EXD3	571	Q8N9H8