Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II C-terminal domain phosphoserine binding	SCAF8 SCAF4	3.33e-05	5	37	2	GO:1990269
GeneOntologyMolecularFunction	RNA polymerase II C-terminal domain binding	SCAF8 SCAF4	1.82e-04	11	37	2	GO:0099122
GeneOntologyMolecularFunction	phosphoserine residue binding	SCAF8 SCAF4	2.18e-04	12	37	2	GO:0050815
GeneOntologyMolecularFunction	mRNA binding	RC3H2 RBM25 TEX13D SNRPC SCAF8 SF1	1.60e-03	694	37	6	GO:0003729
GeneOntologyMolecularFunction	RNA polymerase II complex binding	SCAF8 SCAF4	2.37e-03	39	37	2	GO:0000993
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity, RNA polymerase II-specific	MLXIPL SKI ZBTB4 YLPM1	2.82e-03	320	37	4	GO:0001227
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity	MLXIPL SKI ZBTB4 YLPM1	3.01e-03	326	37	4	GO:0001217
GeneOntologyMolecularFunction	RNA polymerase core enzyme binding	SCAF8 SCAF4	3.15e-03	45	37	2	GO:0043175
GeneOntologyMolecularFunction	transcription coregulator activity	WBP2 SMARCC2 SKI SF1 RXRB	3.59e-03	562	37	5	GO:0003712
GeneOntologyMolecularFunction	chromatin DNA binding	WBP2 SMARCC2 RXRB	3.62e-03	167	37	3	GO:0031490
GeneOntologyBiologicalProcess	mRNA metabolic process	CBLL1 RC3H2 RBM25 SF3B4 PRPF40B SNRPC RBM27 SCAF8 SF1 RXRB SCAF4	3.73e-07	917	37	11	GO:0016071
GeneOntologyBiologicalProcess	mRNA processing	CBLL1 RBM25 SF3B4 PRPF40B SNRPC RBM27 SCAF8 SF1 SCAF4	4.14e-07	551	37	9	GO:0006397
GeneOntologyBiologicalProcess	negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled	SCAF8 SCAF4	3.13e-06	2	37	2	GO:2000805
GeneOntologyBiologicalProcess	negative regulation of termination of RNA polymerase II transcription	SCAF8 SCAF4	3.13e-06	2	37	2	GO:0120191
GeneOntologyBiologicalProcess	negative regulation of termination of DNA-templated transcription	SCAF8 SCAF4	9.38e-06	3	37	2	GO:0060567
GeneOntologyBiologicalProcess	regulation of termination of RNA polymerase II transcription, poly(A)-coupled	SCAF8 SCAF4	9.38e-06	3	37	2	GO:2000804
GeneOntologyBiologicalProcess	termination of RNA polymerase II transcription, poly(A)-coupled	SCAF8 SCAF4	9.38e-06	3	37	2	GO:0030846
GeneOntologyBiologicalProcess	regulation of termination of RNA polymerase II transcription	SCAF8 SCAF4	1.87e-05	4	37	2	GO:1904594
GeneOntologyBiologicalProcess	regulation of termination of DNA-templated transcription	SCAF8 SCAF4	4.68e-05	6	37	2	GO:0031554
GeneOntologyBiologicalProcess	RNA processing	CBLL1 RBM25 SF3B4 PRPF40B SNRPC RBM27 SCAF8 DROSHA SF1 SCAF4	2.27e-04	1500	37	10	GO:0006396
GeneOntologyBiologicalProcess	termination of RNA polymerase II transcription	SCAF8 SCAF4	3.70e-04	16	37	2	GO:0006369
GeneOntologyBiologicalProcess	mRNA splicing, via spliceosome	RBM25 SF3B4 PRPF40B SNRPC SF1	4.23e-04	358	37	5	GO:0000398
GeneOntologyBiologicalProcess	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	RBM25 SF3B4 PRPF40B SNRPC SF1	4.23e-04	358	37	5	GO:0000377
GeneOntologyBiologicalProcess	RNA splicing, via transesterification reactions	RBM25 SF3B4 PRPF40B SNRPC SF1	4.45e-04	362	37	5	GO:0000375
GeneOntologyBiologicalProcess	regulation of T cell differentiation	FOXN1 SMARCC2 RC3H2 DROSHA	6.98e-04	226	37	4	GO:0045580
GeneOntologyBiologicalProcess	spliceosomal complex assembly	SF3B4 SNRPC SF1	7.40e-04	99	37	3	GO:0000245
GeneOntologyCellularComponent	nuclear body	CBLL1 RBM25 SKI PRPF40B SNRPC RBM27 SF1 ZBTB4 YLPM1	2.10e-05	903	37	9	GO:0016604
GeneOntologyCellularComponent	nuclear protein-containing complex	SMARCC2 MLXIPL SF3B4 PYGO2 PRPF40B SNRPC SCAF8 DROSHA SF1 RXRB	1.00e-04	1377	37	10	GO:0140513
GeneOntologyCellularComponent	U2-type prespliceosome	PRPF40B SNRPC	4.58e-04	18	37	2	GO:0071004
GeneOntologyCellularComponent	prespliceosome	PRPF40B SNRPC	4.58e-04	18	37	2	GO:0071010
GeneOntologyCellularComponent	spliceosomal complex	SF3B4 PRPF40B SNRPC SF1	5.51e-04	215	37	4	GO:0005681
GeneOntologyCellularComponent	spliceosomal snRNP complex	SF3B4 PRPF40B SNRPC	6.51e-04	96	37	3	GO:0097525
GeneOntologyCellularComponent	U2-type spliceosomal complex	SF3B4 PRPF40B SNRPC	6.71e-04	97	37	3	GO:0005684
GeneOntologyCellularComponent	small nuclear ribonucleoprotein complex	SF3B4 PRPF40B SNRPC	8.93e-04	107	37	3	GO:0030532
GeneOntologyCellularComponent	nuclear speck	CBLL1 RBM25 PRPF40B RBM27 YLPM1	9.21e-04	431	37	5	GO:0016607
GeneOntologyCellularComponent	Sm-like protein family complex	SF3B4 PRPF40B SNRPC	1.21e-03	119	37	3	GO:0120114
GeneOntologyCellularComponent	U1 snRNP	PRPF40B SNRPC	1.55e-03	33	37	2	GO:0005685
Domain	PWI	RBM25 RBM27	3.60e-05	5	36	2	PF01480
Domain	-	RBM25 RBM27	3.60e-05	5	36	2	1.20.1390.10
Domain	PWI_dom	RBM25 RBM27	3.60e-05	5	36	2	IPR002483
Domain	RRM_1	RBM25 SF3B4 RBM27 SCAF8 SCAF4	4.65e-05	208	36	5	PF00076
Domain	RRM	RBM25 SF3B4 RBM27 SCAF8 SCAF4	5.68e-05	217	36	5	SM00360
Domain	RRM_dom	RBM25 SF3B4 RBM27 SCAF8 SCAF4	7.04e-05	227	36	5	IPR000504
Domain	RRM	RBM25 SF3B4 RBM27 SCAF8 SCAF4	7.49e-05	230	36	5	PS50102
Domain	RNA_pol_II-bd	SCAF8 SCAF4	7.54e-05	7	36	2	IPR006903
Domain	CTD_bind	SCAF8 SCAF4	7.54e-05	7	36	2	PF04818
Domain	-	RBM25 SF3B4 RBM27 SCAF8 SCAF4	9.89e-05	244	36	5	3.30.70.330
Domain	RPR	SCAF8 SCAF4	1.00e-04	8	36	2	SM00582
Domain	CID_dom	SCAF8 SCAF4	1.00e-04	8	36	2	IPR006569
Domain	CID	SCAF8 SCAF4	1.00e-04	8	36	2	PS51391
Domain	Nucleotide-bd_a/b_plait	RBM25 SF3B4 RBM27 SCAF8 SCAF4	1.29e-04	258	36	5	IPR012677
Domain	-	SCAF8 SCAF4	1.14e-03	26	36	2	1.25.40.90
Domain	ENTH_VHS	SCAF8 SCAF4	1.42e-03	29	36	2	IPR008942
Domain	-	CBLL1 RC3H2 PYGO2 SYVN1 PHF3	1.60e-03	449	36	5	3.30.40.10
Domain	Znf_RING/FYVE/PHD	CBLL1 RC3H2 PYGO2 SYVN1 PHF3	1.76e-03	459	36	5	IPR013083
Domain	-	RC3H2 RBM27	2.69e-03	40	36	2	4.10.1000.10
Domain	Znf_FYVE_PHD	PYGO2 PHF3 ZBTB4	2.82e-03	147	36	3	IPR011011
Domain	zf-CCCH	RC3H2 RBM27	4.01e-03	49	36	2	PF00642
Domain	Znf_CCCH	RC3H2 RBM27	5.58e-03	58	36	2	IPR000571
Domain	ZF_C3H1	RC3H2 RBM27	5.58e-03	58	36	2	PS50103
Domain	Zinc_finger_PHD-type_CS	PYGO2 PHF3	6.96e-03	65	36	2	IPR019786
Domain	PHD	PYGO2 PHF3	9.18e-03	75	36	2	PF00628
Domain	Znf_PHD-finger	PYGO2 PHF3	1.01e-02	79	36	2	IPR019787
Domain	Collagen	SFTPA1 COLQ	1.17e-02	85	36	2	PF01391
Domain	Collagen	SFTPA1 COLQ	1.17e-02	85	36	2	IPR008160
Domain	PHD	PYGO2 PHF3	1.27e-02	89	36	2	SM00249
Domain	Znf_PHD	PYGO2 PHF3	1.33e-02	91	36	2	IPR001965
Domain	ZF_PHD_2	PYGO2 PHF3	1.44e-02	95	36	2	PS50016
Pathway	KEGG_SPLICEOSOME	RBM25 SF3B4 PRPF40B SNRPC	3.34e-05	127	21	4	M2044
Pathway	REACTOME_MRNA_SPLICING	RBM25 SF3B4 SNRPC SF1	1.98e-04	201	21	4	MM15411
Pathway	REACTOME_MRNA_SPLICING	RBM25 SF3B4 SNRPC SF1	2.43e-04	212	21	4	M14033
Pathway	WP_MRNA_PROCESSING	RBM25 SF3B4 PRPF40B SNRPC SCAF8	4.36e-04	451	21	5	MM15946
Pathway	REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA	RBM25 SF3B4 SNRPC SF1	6.71e-04	277	21	4	MM15414
Pathway	REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA	RBM25 SF3B4 SNRPC SF1	7.27e-04	283	21	4	M13087
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	DIAPH1 WBP2 SMARCC2 SF3B4 SF1 SCAF4 YLPM1	2.68e-10	154	37	7	16055720
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	CBLL1 SMARCC2 RBM25 SF3B4 SNRPC RBM27 PHF3 SF1 ANXA11 SCAF4 YLPM1	2.78e-09	954	37	11	36373674
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	RC3H2 RBM25 SF3B4 SNRPC RBM27 DROSHA SF1 ANXA11 SCAF4 YLPM1	8.46e-09	807	37	10	22681889
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	DIAPH1 SMARCC2 RBM25 SF3B4 PHF3 SF1 SCAF4 YLPM1	5.06e-08	506	37	8	30890647
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	CBLL1 MLXIPL RBM25 SF3B4 SKI SNRPC RBM27 PHF3 SF1 SCAF4 YLPM1	6.36e-08	1294	37	11	30804502
Pubmed	Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.	DIAPH1 WBP2 SCAF8 DROSHA SCAF4 YLPM1	1.18e-07	220	37	6	24550385
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	CBLL1 SMARCC2 RBM25 SF3B4 SNRPC RBM27 DROSHA SF1 SCAF4 YLPM1	1.32e-07	1082	37	10	38697112
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	DIAPH1 SMARCC2 SF3B4 ZBTB7C SCAF8 RXRB ANXA11 YLPM1	1.48e-07	582	37	8	20467437
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	SMARCC2 PYGO2 SKI RBM27 PHF3 YLPM1	3.77e-07	268	37	6	33640491
Pubmed	SCAF4 and SCAF8, mRNA Anti-Terminator Proteins.	SCAF8 SCAF4	1.10e-06	2	37	2	31104839
Pubmed	Knockdown of Drosha in human alveolar type II cells alters expression of SP-A in culture: a pilot study.	SFTPA1 DROSHA	1.10e-06	2	37	2	25058539
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	SMARCC2 RC3H2 RBM25 SF3B4 RBM27 PHF3 DROSHA SF1 SCAF4 YLPM1	1.15e-06	1371	37	10	36244648
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	SF3B4 RBM27 SCAF8 SF1 YLPM1	1.34e-06	180	37	5	35198878
Pubmed	A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.	RBM25 SF3B4 RBM27 SCAF8 SF1 SCAF4	1.69e-06	347	37	6	16033648
Pubmed	Prp40 pre-mRNA processing factor 40 homolog B (PRPF40B) associates with SF1 and U2AF65 and modulates alternative pre-mRNA splicing in vivo.	PRPF40B SF1	3.30e-06	3	37	2	25605964
Pubmed	Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of the carboxyl-terminal domain of RNA polymerase II.	SCAF8 SCAF4	3.30e-06	3	37	2	18550522
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	SMARCC2 RBM25 SF3B4 SNRPC SF1 YLPM1	3.78e-06	399	37	6	35987950
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	PYGO2 PRPF40B SNRPC RBM27 SCAF8 YLPM1	8.20e-06	457	37	6	32344865
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	SMARCC2 RBM25 SCAF8 PHF3 SF1 SCAF4 YLPM1	1.51e-05	774	37	7	15302935
Pubmed	Proteomic analysis of the cullin 4B interactome using proximity-dependent biotinylation in living cells.	SMARCC2 RBM25 SF1 ANXA11	2.12e-05	153	37	4	28225217
Pubmed	The genetic origin of mouse annexin VIII.	SFTPA1 ANXA11	2.30e-05	7	37	2	9434938
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	WBP2 RBM25 RBM27 PHF3 SCAF4 YLPM1	2.31e-05	549	37	6	38280479
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	SMARCC2 RBM25 SF3B4 RBM27 PHF3 DROSHA SF1	2.70e-05	847	37	7	35850772
Pubmed	Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.	SMARCC2 RBM25 SF3B4 SNRPC	3.21e-05	170	37	4	16159877
Pubmed	RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma.	SNRPC RBM27 PHF3 SMR3B	4.28e-05	183	37	4	28186131
Pubmed	Recognition sequences for the GYF domain reveal a possible spliceosomal function of CD2BP2.	SF3B4 SF1	4.93e-05	10	37	2	15105431
Pubmed	Dynamic protein-protein interaction wiring of the human spliceosome.	RBM25 SF3B4 SNRPC SF1	5.70e-05	197	37	4	22365833
Pubmed	Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.	RBM25 YLPM1	7.22e-05	12	37	2	7596406
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	DIAPH1 SMARCC2 RBM25 RBM27 PHF3 SF1 YLPM1	8.40e-05	1014	37	7	32416067
Pubmed	The arginine methyltransferase CARM1 regulates the coupling of transcription and mRNA processing.	SF3B4 SNRPC	8.53e-05	13	37	2	17218272
Pubmed	The protein interaction landscape of the human CMGC kinase group.	RBM25 SF3B4 SKI SNRPC PHF3 DROSHA	8.55e-05	695	37	6	23602568
Pubmed	Human transcription factor protein interaction networks.	SMARCC2 RBM25 PYGO2 SKI RBM27 SCAF8 SCAF4 YLPM1	1.06e-04	1429	37	8	35140242
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	RC3H2 SF3B4 RBM27 PHF3 SF1 YLPM1	1.07e-04	724	37	6	36232890
Pubmed	A germline-specific class of small RNAs binds mammalian Piwi proteins.	WBP2 CDIP1 SF3B4 SYVN1 ZBTB4	1.10e-04	450	37	5	16751776
Pubmed	Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.	CBLL1 RBM25 SF3B4 SNRPC RBM27 SF1	1.13e-04	731	37	6	29298432
Pubmed	Inhibition of Glycolysis in Pathogenic TH17 Cells through Targeting a miR -21-Peli1-c-Rel Pathway Prevents Autoimmunity.	RBM25 SKI	1.31e-04	16	37	2	32414810
Pubmed	FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3.	RBM25 SF3B4 SF1 YLPM1	1.39e-04	248	37	4	27926873
Pubmed	Affinity purification strategies for proteomic analysis of transcription factor complexes.	SMARCC2 SNRPC SF1	1.53e-04	97	37	3	23937658
Pubmed	Global proteomics of Ubqln2-based murine models of ALS.	WBP2 SF3B4 SNRPC ANXA11	1.68e-04	261	37	4	33277362
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	RBM25 PYGO2 RBM27 PHF3 SF1	1.85e-04	503	37	5	16964243
Pubmed	The DNA sequence and analysis of human chromosome 14.	RBM25 MAPK1IP1L YLPM1	2.27e-04	111	37	3	12508121
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	RBM27 PHF3 SF1 YLPM1	2.29e-04	283	37	4	30585729
Pubmed	Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor.	SF3B4 SNRPC SF1	2.39e-04	113	37	3	23403292
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	CBLL1 SMARCC2 SF3B4 SYVN1 RBM27 PHF3 SF1	2.41e-04	1203	37	7	29180619
Pubmed	Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes.	SF3B4 SNRPC SF1	2.52e-04	115	37	3	17332742
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	DIAPH1 WBP2 SMARCC2 RBM25 SF3B4 PHF3 SF1	3.00e-04	1247	37	7	27684187
Pubmed	The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo.	SF3B4 SF1	3.25e-04	25	37	2	15456888
Pubmed	Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex.	SF3B4 SF1	3.25e-04	25	37	2	9731529
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	RBM25 RBM27 SF1	3.61e-04	130	37	3	35545047
Pubmed	A census of human transcription factors: function, expression and evolution.	FOXN1 MLXIPL RC3H2 SKI RXRB ZBTB4	3.63e-04	908	37	6	19274049
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	CBLL1 WBP2 SF3B4 SNRPC SCAF4 YLPM1	3.93e-04	922	37	6	27609421
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	DIAPH1 RBM25 SF3B4 SNRPC RBM27 SCAF8 SF1	4.19e-04	1318	37	7	30463901
Pubmed	PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.	SMARCC2 RBM25 RBM27 SCAF4	4.59e-04	340	37	4	24332808
Pubmed	WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.	WBP2 SMARCC2 SF3B4 SNRPC DROSHA	4.64e-04	615	37	5	31048545
Pubmed	Identification of interaction partners for individual SH3 domains of Fas ligand associated members of the PCH protein family in T lymphocytes.	DIAPH1 YLPM1	5.02e-04	31	37	2	19041431
Pubmed	HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.	RBM27 SF1 YLPM1	5.28e-04	148	37	3	32538781
Pubmed	Fine-mapping quantitative trait loci affecting murine external ear tissue regeneration in the LG/J by SM/J advanced intercross line.	DIAPH1 SMARCC2	5.69e-04	33	37	2	24569637
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	SMARCC2 RBM25 RBM27 PHF3 SF1 YLPM1	5.70e-04	989	37	6	36424410
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	SF3B4 SNRPC SF1	5.70e-04	152	37	3	38360978
Pubmed	Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry.	SF3B4 SCAF8	6.05e-04	34	37	2	11101529
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	SMARCC2 RBM25 PHF3 ANXA11 YLPM1	6.09e-04	653	37	5	22586326
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	RBM25 SF3B4 SNRPC SF1 YLPM1	6.39e-04	660	37	5	32780723
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	SMARCC2 RBM25 SF1 ANXA11 SCAF4 YLPM1	6.84e-04	1024	37	6	24711643
Pubmed	PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.	RC3H2 RBM25 SNRPC RBM27 SF1	7.22e-04	678	37	5	30209976
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	SFTPA1 COLQ ANXA11	7.49e-04	167	37	3	22159717
Pubmed	Cellular substrates and pro-apoptotic function of the human HtrA4 protease.	CBLL1 SF3B4 ANXA11	8.30e-04	173	37	3	31470122
Pubmed	Citron kinase interacts with LATS2 and inhibits its activity by occluding its hydrophobic phosphorylation motif.	WBP2 ANXA11	8.37e-04	40	37	2	30865227
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	RBM25 SF3B4 SNRPC RBM27 SCAF4	9.04e-04	713	37	5	29802200
Pubmed	Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation.	SMARCC2 RBM25 SF1	9.31e-04	180	37	3	30110629
Pubmed	Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.	RBM25 RBM27 YLPM1	9.61e-04	182	37	3	32239614
Pubmed	Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event.	SMARCC2 RBM25 SNRPC	9.61e-04	182	37	3	26527279
Pubmed	Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.	SMARCC2 RC3H2 SF3B4 SNRPC SF1	9.62e-04	723	37	5	34133714
Interaction	TLE3 interactions	CBLL1 SMARCC2 PYGO2 PRPF40B SNRPC SCAF8 SCAF4 ZBTB4	1.62e-07	376	34	8	int:TLE3
Interaction	DDX17 interactions	CBLL1 WBP2 SMARCC2 RC3H2 SF3B4 SNRPC SF1 YLPM1	4.19e-07	426	34	8	int:DDX17
Interaction	SMC5 interactions	CBLL1 SMARCC2 RBM25 SF3B4 SNRPC RBM27 PHF3 SF1 ANXA11 SCAF4 YLPM1	4.24e-07	1000	34	11	int:SMC5
Interaction	PRPF40A interactions	DIAPH1 SMARCC2 RBM25 SF3B4 SNRPC SF1 SCAF4 YLPM1	5.92e-07	446	34	8	int:PRPF40A
Interaction	SP7 interactions	SMARCC2 RBM25 PYGO2 RBM27 SCAF8 SCAF4 YLPM1	6.29e-07	304	34	7	int:SP7
Interaction	MECP2 interactions	CBLL1 SMARCC2 RBM25 SF3B4 SKI PRPF40B SNRPC RBM27 DROSHA SF1 SCAF4 YLPM1	6.42e-07	1287	34	12	int:MECP2
Interaction	FUBP1 interactions	SMARCC2 RBM25 PRPF40B SNRPC RBM27 MAPK1IP1L ANXA11	7.02e-07	309	34	7	int:FUBP1
Interaction	SNRNP40 interactions	CBLL1 SMARCC2 RC3H2 RBM25 PRPF40B SNRPC SCAF8 SCAF4 ZBTB4	7.69e-07	637	34	9	int:SNRNP40
Interaction	CDC5L interactions	DIAPH1 SMARCC2 RC3H2 SF3B4 ZBTB7C SNRPC SCAF8 RXRB ANXA11 YLPM1	9.29e-07	855	34	10	int:CDC5L
Interaction	SNRPA interactions	RC3H2 RBM25 SF3B4 SNRPC PHF3 SF1 SCAF4 YLPM1	1.06e-06	482	34	8	int:SNRPA
Interaction	CPSF6 interactions	CBLL1 SMARCC2 RC3H2 RBM25 SNRPC PHF3 SCAF4 YLPM1	2.04e-06	526	34	8	int:CPSF6
Interaction	HNRNPA1 interactions	RC3H2 SF3B4 SNRPC RBM27 SCAF8 PHF3 DROSHA SF1 SCAF4 YLPM1	2.30e-06	945	34	10	int:HNRNPA1
Interaction	FUS interactions	SMARCC2 RC3H2 RBM25 SF3B4 SNRPC PHF3 SF1 SCAF4 YLPM1	3.20e-06	757	34	9	int:FUS
Interaction	SNRPC interactions	RC3H2 RBM25 SF3B4 SNRPC PHF3 SCAF4 YLPM1	7.28e-06	440	34	7	int:SNRPC
Interaction	WWOX interactions	DIAPH1 WBP2 SNRPC SCAF8 DROSHA ANXA11 SCAF4 YLPM1	7.45e-06	627	34	8	int:WWOX
Interaction	CELF1 interactions	RC3H2 RBM27 SCAF8 SF1 SCAF4 YLPM1	7.77e-06	288	34	6	int:CELF1
Interaction	P4HA1 interactions	SF3B4 SYVN1 COLQ PRPF40B SNRPC YLPM1	9.43e-06	298	34	6	int:P4HA1
Interaction	SNRPA1 interactions	SMARCC2 RC3H2 RBM25 SF3B4 SNRPC SF1	9.80e-06	300	34	6	int:SNRPA1
Interaction	RBM25 interactions	SMARCC2 RC3H2 RBM25 SF3B4 PRPF40B SNRPC	1.49e-05	323	34	6	int:RBM25
Interaction	ACTC1 interactions	DIAPH1 SMARCC2 RBM25 SF3B4 PHF3 SF1 SCAF4 YLPM1	1.56e-05	694	34	8	int:ACTC1
Interaction	DTX2 interactions	PRR32 SF3B4 RBM27 SCAF8 SF1 YLPM1	1.68e-05	330	34	6	int:DTX2
Interaction	POLR2C interactions	SMARCC2 SNRPC SCAF8 PHF3 CNTRL SCAF4	1.93e-05	338	34	6	int:POLR2C
Interaction	SS18L1 interactions	SMARCC2 SF3B4 SNRPC MAPK1IP1L	2.18e-05	98	34	4	int:SS18L1
Interaction	WDR77 interactions	RC3H2 SF3B4 SKI SNRPC SF1 YLPM1	2.79e-05	361	34	6	int:WDR77
Interaction	MPLKIP interactions	SF3B4 RBM27 SF1	3.02e-05	36	34	3	int:MPLKIP
Interaction	WBP4 interactions	DIAPH1 SF3B4 SF1 SCAF4	3.31e-05	109	34	4	int:WBP4
Interaction	SNRPF interactions	SF3B4 SNRPC PHF3 SCAF4 YLPM1 SMR3B	4.00e-05	385	34	6	int:SNRPF
Interaction	LUC7L interactions	RC3H2 RBM25 SNRPC RBM27 SCAF4	5.02e-05	242	34	5	int:LUC7L
Interaction	RBM10 interactions	CBLL1 RC3H2 SF3B4 SNRPC SF1	6.19e-05	253	34	5	int:RBM10
Interaction	NUP35 interactions	PYGO2 PRPF40B SNRPC RBM27 SCAF8 YLPM1	6.83e-05	424	34	6	int:NUP35
Interaction	HDLBP interactions	SMARCC2 RBM25 SF3B4 RBM27 DROSHA SF1 SCAF4 YLPM1	6.90e-05	855	34	8	int:HDLBP
Interaction	CWC15 interactions	RBM25 SF3B4 SNRPC SF1	7.42e-05	134	34	4	int:CWC15
Interaction	BCAS2 interactions	RC3H2 RBM25 SF3B4 SNRPC SF1	8.42e-05	270	34	5	int:BCAS2
Interaction	GAGE5 interactions	RBM25 PHF3 SCAF4	9.16e-05	52	34	3	int:GAGE5
Interaction	RBFOX2 interactions	RC3H2 SF3B4 SNRPC MAPK1IP1L SF1	1.07e-04	284	34	5	int:RBFOX2
Interaction	SF3A1 interactions	SMARCC2 RBM25 SF3B4 SNRPC SF1 YLPM1	1.22e-04	471	34	6	int:SF3A1
Interaction	TOP1 interactions	DIAPH1 SMARCC2 RBM25 SNRPC PHF3 SCAF4 YLPM1	1.35e-04	696	34	7	int:TOP1
Interaction	YLPM1 interactions	SMARCC2 SNRPC DROSHA YLPM1	1.47e-04	160	34	4	int:YLPM1
Interaction	BCHE interactions	COLQ SF1 SMR3B	1.78e-04	65	34	3	int:BCHE
Interaction	SNRPB interactions	RBM25 SF3B4 SNRPC PHF3 SCAF4 YLPM1	2.02e-04	517	34	6	int:SNRPB
Interaction	PPP4R3A interactions	SMARCC2 RBM25 SF3B4 SCAF4	2.27e-04	179	34	4	int:PPP4R3A
Interaction	ALG13 interactions	RC3H2 RBM25 SCAF8 SF1	2.47e-04	183	34	4	int:ALG13
Interaction	SRRM1 interactions	SMARCC2 RC3H2 RBM25 SF3B4 SNRPC	2.75e-04	348	34	5	int:SRRM1
Interaction	SRPK3 interactions	SF3B4 SNRPC DROSHA SCAF4	2.85e-04	190	34	4	int:SRPK3
Interaction	HNRNPUL1 interactions	RC3H2 SF3B4 SNRPC MAPK1IP1L SF1	2.86e-04	351	34	5	int:HNRNPUL1
Interaction	NXF1 interactions	SMARCC2 RBM25 PYGO2 SNRPC RBM27 SCAF8 DROSHA SF1 YLPM1	2.92e-04	1345	34	9	int:NXF1
Interaction	APBB1 interactions	DIAPH1 SF3B4 SF1 YLPM1	3.14e-04	195	34	4	int:APBB1
Interaction	SFPQ interactions	CBLL1 SMARCC2 SF3B4 RBM27 SF1 YLPM1	3.20e-04	563	34	6	int:SFPQ
Interaction	WDR83 interactions	SF3B4 SNRPC SF1 CNTRL	3.20e-04	196	34	4	int:WDR83
Interaction	CELA2A interactions	SKI YLPM1	3.27e-04	16	34	2	int:CELA2A
Interaction	DOT1L interactions	SMARCC2 RBM25 SF3B4 RBM27 PHF3 DROSHA SF1	3.36e-04	807	34	7	int:DOT1L
Interaction	RAMAC interactions	SF3B4 SNRPC MAPK1IP1L	3.55e-04	82	34	3	int:RAMAC
Interaction	PUF60 interactions	DIAPH1 RC3H2 RBM25 SF3B4 SF1	3.60e-04	369	34	5	int:PUF60
Interaction	PDCD6 interactions	SMARCC2 DROSHA MAPK1IP1L ANXA11	3.73e-04	204	34	4	int:PDCD6
Interaction	KHDRBS1 interactions	CBLL1 RC3H2 SNRPC DROSHA YLPM1	3.78e-04	373	34	5	int:KHDRBS1
Interaction	YAP1 interactions	WBP2 SMARCC2 CDIP1 RBM25 PHF3 DROSHA SCAF4 YLPM1	3.79e-04	1095	34	8	int:YAP1
Interaction	JMJD6 interactions	RBM25 RBM27 SCAF8 SCAF4	3.80e-04	205	34	4	int:JMJD6
Interaction	TCERG1 interactions	DIAPH1 SF3B4 SNRPC SF1	3.94e-04	207	34	4	int:TCERG1
Interaction	NR2C2 interactions	DIAPH1 RC3H2 RBM25 SF3B4 SNRPC RBM27 SCAF8 SF1 RXRB	4.00e-04	1403	34	9	int:NR2C2
Interaction	WWP2 interactions	WBP2 SMARCC2 SF3B4 SNRPC DROSHA SF1 YLPM1	4.28e-04	840	34	7	int:WWP2
Interaction	ZC3H11A interactions	SF3B4 SNRPC RBM27 SF1	4.54e-04	215	34	4	int:ZC3H11A
Interaction	RGS9 interactions	RBM25 PRPF40B	4.64e-04	19	34	2	int:RGS9
Interaction	DMRTB1 interactions	SF3B4 SNRPC SF1	5.30e-04	94	34	3	int:DMRTB1
Interaction	BAG4 interactions	RC3H2 SF3B4 SNRPC SF1	5.30e-04	224	34	4	int:BAG4
Interaction	PRPF40B interactions	RBM25 PRPF40B	5.69e-04	21	34	2	int:PRPF40B
Interaction	TAF15 interactions	SMARCC2 RC3H2 RBM25 SNRPC SF1	5.69e-04	408	34	5	int:TAF15
Interaction	ILF3 interactions	DIAPH1 RC3H2 SF3B4 SNRPC DROSHA SF1 YLPM1	6.29e-04	896	34	7	int:ILF3
Interaction	SMAD5 interactions	WBP2 SKI DROSHA	6.53e-04	101	34	3	int:SMAD5
Interaction	EWSR1 interactions	SMARCC2 RC3H2 SF3B4 SNRPC MAPK1IP1L SF1 ANXA11	6.72e-04	906	34	7	int:EWSR1
Interaction	EYA4 interactions	SF3B4 SNRPC MAPK1IP1L SF1	7.20e-04	243	34	4	int:EYA4
Interaction	ANKRD50 interactions	RBM25 PHF3 YLPM1	7.94e-04	108	34	3	int:ANKRD50
Interaction	CRTAP interactions	SF3B4 COLQ SMR3B	7.94e-04	108	34	3	int:CRTAP
Interaction	SNRPB2 interactions	RBM25 SF3B4 SNRPC SF1	8.61e-04	255	34	4	int:SNRPB2
Interaction	RBMX interactions	RC3H2 SF3B4 SNRPC SF1 YLPM1	9.86e-04	461	34	5	int:RBMX
Interaction	PRMT5 interactions	SMARCC2 RC3H2 SF3B4 SKI SNRPC	1.09e-03	471	34	5	int:PRMT5
Interaction	SNRNP70 interactions	SMARCC2 RC3H2 RBM25 SF3B4 SNRPC RBM27 SCAF4	1.09e-03	984	34	7	int:SNRNP70
Interaction	AR interactions	SMARCC2 RBM25 PYGO2 SKI RBM27 PHF3 YLPM1	1.15e-03	992	34	7	int:AR
Interaction	HNRNPM interactions	RC3H2 RBM25 SF3B4 SKI SNRPC SF1	1.19e-03	723	34	6	int:HNRNPM
Interaction	H2AJ interactions	RBM25 RBM27 PHF3	1.27e-03	127	34	3	int:H2AJ
Interaction	NR1H4 interactions	MLXIPL RXRB	1.33e-03	32	34	2	int:NR1H4
Interaction	RECQL interactions	SNRPC RBM27 PHF3 SMR3B	1.37e-03	289	34	4	int:RECQL
Interaction	ZBTB7A interactions	SMARCC2 ZBTB7C ZBTB4	1.39e-03	131	34	3	int:ZBTB7A
Interaction	PRPF3 interactions	RC3H2 RBM25 SNRPC PHF3	1.40e-03	291	34	4	int:PRPF3
Interaction	NKAP interactions	RC3H2 RBM25 SNRPC	1.42e-03	132	34	3	int:NKAP
Interaction	DHX8 interactions	RBM25 SNRPC RBM27 YLPM1	1.42e-03	292	34	4	int:DHX8
Interaction	RBM39 interactions	RC3H2 RBM25 SF3B4 SNRPC DROSHA SF1 YLPM1	1.52e-03	1042	34	7	int:RBM39
Cytoband	Xq25	PRR32 TEX13D	5.08e-04	41	37	2	Xq25
Cytoband	Ensembl 112 genes in cytogenetic band chrXq25	PRR32 TEX13D	6.96e-04	48	37	2	chrXq25
Cytoband	14q24.3	RBM25 YLPM1	2.58e-03	93	37	2	14q24.3
Cytoband	11q13	SYVN1 SF1	4.11e-03	118	37	2	11q13
Cytoband	Ensembl 112 genes in cytogenetic band chr9q33	RC3H2 CNTRL	5.58e-03	138	37	2	chr9q33
GeneFamily	RNA binding motif containing	RBM25 SF3B4 RBM27 SCAF8 SCAF4	4.84e-06	213	22	5	725
GeneFamily	Zinc fingers CCCH-type	RC3H2 RBM27	8.21e-04	35	22	2	73
GeneFamily	Ring finger proteins	CBLL1 RC3H2 SYVN1	4.33e-03	275	22	3	58
GeneFamily	PHD finger proteins	PYGO2 PHF3	5.31e-03	90	22	2	88
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	ZBTB7C ZBTB4	1.14e-02	134	22	2	861
Coexpression	TABULA_MURIS_SENIS_HEART_VALVE_CELL_AGEING	CYSTM1 WBP2 SF3B4 SNRPC	2.66e-05	126	36	4	MM3709
Coexpression	GSE45365_HEALTHY_VS_MCMV_INFECTION_CD11B_DC_UP	SMARCC2 PYGO2 RBM27 SCAF8	1.29e-04	189	36	4	M9978
Coexpression	BUSSLINGER_GASTRIC_IMMUNE_CELLS	DIAPH1 SKI RBM27 SCAF8 PHF3 MAPK1IP1L SF1 CNTRL ZBTB4	1.42e-04	1492	36	9	M40023
Coexpression	GSE42021_TREG_PLN_VS_CD24LO_TREG_THYMUS_UP	COLQ RXRB KIAA0586 SCAF4	1.48e-04	196	36	4	M9578
Coexpression	GSE46606_IRF4MID_VS_WT_CD40L_IL2_IL5_DAY1_STIMULATED_BCELL_UP	SKI PHF3 DROSHA KIAA0586	1.57e-04	199	36	4	M9850
Coexpression	GSE15930_NAIVE_VS_72H_IN_VITRO_STIM_TRICHOSTATINA_CD8_TCELL_UP	DIAPH1 RC3H2 SCAF8 CNTRL	1.60e-04	200	36	4	M3614
Coexpression	GSE43955_TGFB_IL6_VS_TGFB_IL6_IL23_TH17_ACT_CD4_TCELL_60H_UP	CDIP1 RC3H2 COLQ RXRB	1.60e-04	200	36	4	M9671
Coexpression	GSE37416_CTRL_VS_24H_F_TULARENSIS_LVS_NEUTROPHIL_DN	DIAPH1 CYSTM1 MAPK1IP1L ANXA11	1.60e-04	200	36	4	M5338
Coexpression	TABULA_MURIS_SENIS_MARROW_MATURE_ALPHA_BETA_T_CELL_AGEING	DIAPH1 WBP2 SF3B4 SYVN1 SNRPC ANXA11	1.70e-04	612	36	6	MM3804
Coexpression	STARK_PREFRONTAL_CORTEX_22Q11_DELETION_UP	CBLL1 SMARCC2 RBM25 SKI	1.79e-04	206	36	4	M2817
Coexpression	STARK_PREFRONTAL_CORTEX_22Q11_DELETION_UP	CBLL1 SMARCC2 RBM25 SKI	1.86e-04	208	36	4	MM581
Drug	Etifenin [63245-28-3]; Down 200; 12.4uM; PC3; HT_HG-U133A	SMARCC2 RC3H2 RBM25 SKI PHF3	7.41e-06	178	35	5	3998_DN
Disease	syndrome (implicated_via_orthology)	SCAF8 SCAF4	1.95e-04	18	34	2	DOID:225 (implicated_via_orthology)
Disease	serum urea measurement	ZBTB7C SCAF8 ANXA11	1.46e-03	195	34	3	EFO_0009795
Disease	blood urea nitrogen measurement	CYSTM1 MLXIPL ZBTB7C SCAF8	1.75e-03	452	34	4	EFO_0004741
Disease	factor VII measurement	MLXIPL SF1	1.84e-03	55	34	2	EFO_0004619
Disease	atypical femoral fracture, response to bisphosphonate	SFTPA1 SCAF8	2.80e-03	68	34	2	EFO_0009958, EFO_0009960
Disease	hemoglobin A1 measurement	MLXIPL RC3H2 ZBTB7C SKI	2.91e-03	520	34	4	EFO_0007629
Disease	total cholesterol measurement, high density lipoprotein cholesterol measurement	MLXIPL COLQ SNRPC	5.65e-03	315	34	3	EFO_0004574, EFO_0004612

Protein segments in the cluster

Peptide	Gene	Start	Entry
PPPYEPPGHPMPQPG	CDIP1	51	Q9H305
PPAGAPMVYGPPPPN	CNTRL	1286	Q7Z7A1
PPYPGAPVPGQPMPP	ANXA11	121	P50995
PPPGMGMPPPPPFGF	DIAPH1	741	O60610
PPQPYGPVPPVPSGM	RC3H2	676	Q9HBD1
FPGFPPPVPPGTPMI	RBM25	26	P49756
PSMIPFPPPPPGLPP	RBM27	311	Q9P2N5
PPPPPLFPPPFFRGG	COLQ	56	Q9Y215
YAPPPPPPPPISHPM	CBLL1	341	Q75N03
RQPPPFPPNPMGPAF	PYGO2	131	Q9BRQ0
APYPPYPPQPMGPGP	CYSTM1	16	Q9H1C7
PMHLPPGFLPPGPPP	SCAF4	731	O95104
PPAFPVSMPVPPPGF	SCAF8	656	Q9UPN6
GFMPPPVPPPVVPPP	SCAF8	691	Q9UPN6
MPFPPMPPPPAPAPG	PRR18	1	Q8N4B5
MYPSVPPTGPPPGPP	MAPK1IP1L	71	Q8NDC0
PPMGPFPPVPPPPSS	SYVN1	386	Q86TM6
PPPFAFPPMPVPPAG	SYVN1	466	Q86TM6
FPPPMPPSAQGPLPP	DROSHA	81	Q9NRR4
FPVPPCFPPMPPPMP	DROSHA	111	Q9NRR4
PFSAPPPAGAMIPPP	SNRPC	66	P09234
PFPAPPAPPFPAAPG	TGFBR3L	41	H3BV60
MPPPQPPPHCFPPGP	FOXN1	571	O15353
FGPGFVPPPPPPPYG	SMR3B	41	P02814
MPLPFAPPPIFGPPL	PRR32	261	B1ATL7
GLEPCPPPPFPPMAP	MLXIPL	406	Q9NP71
PPPPFPPMAPPTALL	MLXIPL	411	Q9NP71
LPFGMPPPPPPPAPS	SMARCC2	1081	Q8TAQ2
PPGPMGPPGEMPCPP	SFTPA1	56	Q8IWL2
PPPPVLPGPFFMPSD	SKI	81	P12755
PPPMPPPPLGSPFPV	RXRB	121	P28702
PPFPMKFPSLPPLPP	TEX13D	231	A0A0J9YY54
PAPVAMPASPPPGPP	ZBTB4	446	Q9P1Z0
SPPGFPFPGPPNFPP	PHF3	1811	Q92576
FMPPPGIPPPFPPMG	PRPF40B	6	Q6NWY9
GYGDWQPPPPPMPPP	YLPM1	96	P49750
PPESPPVPPGSYMPP	YLPM1	146	P49750
ELPPPPPPPFPNDFF	ZBTB7C	296	A1YPR0
MYAPPPPPPPPMDPS	SF1	596	Q15637
AGMPPFGMPPAPPPP	SF1	621	Q15637
GLPPPGMPPPGSFPP	SF3B4	231	Q15427
GMPPPGSFPPPVPPP	SF3B4	236	Q15427
FPAQPPPPEPVPFMP	KIAA0586	1176	Q9BVV6
PPPEPVPFMPFPAGT	KIAA0586	1181	Q9BVV6
PPPPYPGPMEPPVSG	WBP2	196	Q969T9