Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	glycogen phosphorylase activity	PYGB PYGM	1.06e-05	3	38	2	GO:0008184
GeneOntologyMolecularFunction	amine sulfotransferase activity	SULT1A4 SULT1A3	2.11e-05	4	38	2	GO:0047685
GeneOntologyMolecularFunction	tyrosine-ester sulfotransferase activity	SULT1A4 SULT1A3	2.11e-05	4	38	2	GO:0017067
GeneOntologyMolecularFunction	small conductance calcium-activated potassium channel activity	KCNN2 KCNN4	2.11e-05	4	38	2	GO:0016286
GeneOntologyMolecularFunction	1,4-alpha-oligoglucan phosphorylase activity	PYGB PYGM	3.51e-05	5	38	2	GO:0004645
GeneOntologyMolecularFunction	flavonol 3-sulfotransferase activity	SULT1A4 SULT1A3	3.51e-05	5	38	2	GO:0047894
GeneOntologyMolecularFunction	steroid sulfotransferase activity	SULT1A4 SULT1A3	7.36e-05	7	38	2	GO:0050294
GeneOntologyMolecularFunction	sulfate binding	SULT1A4 SULT1A3	1.26e-04	9	38	2	GO:0043199
GeneOntologyMolecularFunction	aryl sulfotransferase activity	SULT1A4 SULT1A3	1.57e-04	10	38	2	GO:0004062
GeneOntologyMolecularFunction	pyridoxal phosphate binding	PYGB PYGM CTH	1.64e-04	56	38	3	GO:0030170
GeneOntologyMolecularFunction	vitamin B6 binding	PYGB PYGM CTH	1.73e-04	57	38	3	GO:0070279
GeneOntologyMolecularFunction	3'-phosphoadenosine 5'-phosphosulfate binding	SULT1A4 SULT1A3	2.71e-04	13	38	2	GO:0050656
GeneOntologyMolecularFunction	calcium-activated potassium channel activity	KCNN2 KCNN4	3.16e-04	14	38	2	GO:0015269
GeneOntologyMolecularFunction	calmodulin binding	KCNN2 KCNN4 CTH RYR1	9.31e-04	230	38	4	GO:0005516
GeneOntologyMolecularFunction	calcium-activated cation channel activity	KCNN2 KCNN4	1.20e-03	27	38	2	GO:0005227
GeneOntologyMolecularFunction	inward rectifier potassium channel activity	KCNN2 KCNN4	1.29e-03	28	38	2	GO:0005242
GeneOntologyMolecularFunction	monoatomic ion-gated channel activity	KCNN2 KCNN4	1.58e-03	31	38	2	GO:0022839
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	CHD8 EP400	2.25e-03	37	38	2	GO:0140658
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	KCNN2 KCNN4 RYR1	2.38e-03	140	38	3	GO:0099094
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	KCNN2 KCNN4 RYR1	3.00e-03	152	38	3	GO:0022843
GeneOntologyMolecularFunction	vitamin binding	PYGB PYGM CTH	3.53e-03	161	38	3	GO:0019842
GeneOntologyMolecularFunction	sulfotransferase activity	SULT1A4 SULT1A3	4.91e-03	55	38	2	GO:0008146
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	KCNN2 KCNN4 RYR1	4.97e-03	182	38	3	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	KCNN2 KCNN4 RYR1	5.12e-03	184	38	3	GO:0022832
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	KCNN2 KCNN4 RYR1	5.85e-03	193	38	3	GO:0015276
GeneOntologyMolecularFunction	ligand-gated channel activity	KCNN2 KCNN4 RYR1	6.19e-03	197	38	3	GO:0022834
GeneOntologyMolecularFunction	hexosyltransferase activity	PYGB PYGM MGAT4C	7.48e-03	211	38	3	GO:0016758
GeneOntologyMolecularFunction	transferase activity, transferring sulphur-containing groups	SULT1A4 SULT1A3	8.74e-03	74	38	2	GO:0016782
GeneOntologyBiologicalProcess	4-nitrophenol metabolic process	SULT1A4 SULT1A3	3.29e-05	5	38	2	GO:0018960
GeneOntologyBiologicalProcess	dopamine catabolic process	SULT1A4 SULT1A3	1.47e-04	10	38	2	GO:0042420
GeneOntologyBiologicalProcess	catecholamine catabolic process	SULT1A4 SULT1A3	1.80e-04	11	38	2	GO:0042424
GeneOntologyBiologicalProcess	catechol-containing compound catabolic process	SULT1A4 SULT1A3	1.80e-04	11	38	2	GO:0019614
GeneOntologyBiologicalProcess	flavonoid metabolic process	SULT1A4 SULT1A3	2.55e-04	13	38	2	GO:0009812
GeneOntologyBiologicalProcess	positive regulation of non-motile cilium assembly	ATMIN TMEM67	2.55e-04	13	38	2	GO:1902857
GeneOntologyBiologicalProcess	phenol-containing compound catabolic process	SULT1A4 SULT1A3	2.97e-04	14	38	2	GO:0019336
GeneOntologyBiologicalProcess	purine ribonucleoside bisphosphate metabolic process	SULT1A4 SULT1A3	4.42e-04	17	38	2	GO:0034035
GeneOntologyBiologicalProcess	3'-phosphoadenosine 5'-phosphosulfate metabolic process	SULT1A4 SULT1A3	4.42e-04	17	38	2	GO:0050427
GeneOntologyBiologicalProcess	ethanol catabolic process	SULT1A4 SULT1A3	4.42e-04	17	38	2	GO:0006068
GeneOntologyBiologicalProcess	ethanol metabolic process	SULT1A4 SULT1A3	4.96e-04	18	38	2	GO:0006067
GeneOntologyBiologicalProcess	regulation of non-motile cilium assembly	ATMIN TMEM67	4.96e-04	18	38	2	GO:1902855
GeneOntologyBiologicalProcess	biogenic amine catabolic process	SULT1A4 SULT1A3	6.15e-04	20	38	2	GO:0042402
GeneOntologyBiologicalProcess	amine catabolic process	SULT1A4 SULT1A3	7.46e-04	22	38	2	GO:0009310
GeneOntologyBiologicalProcess	primary alcohol catabolic process	SULT1A4 SULT1A3	8.16e-04	23	38	2	GO:0034310
MousePheno	abnormal skeletal muscle morphology	VAPB PYGM CTH SULT1A4 CMYA5 SULT1A3 RYR1 PRRC2B	1.79e-05	508	33	8	MP:0000759
MousePheno	pectus excavatum	SOX5 RYR1	5.38e-05	5	33	2	MP:0012514
MousePheno	abnormal primitive streak morphology	ATMIN TMEM67 FASTKD5 CHD8 KIAA0586	1.00e-04	201	33	5	MP:0002231
MousePheno	abnormal motile primary cilium morphology	ATMIN TMEM67 KIAA0586	1.39e-04	43	33	3	MP:0004131
MousePheno	abnormal primitive node morphology	ATMIN TMEM67 FASTKD5 KIAA0586	1.58e-04	117	33	4	MP:0004066
Domain	Glyco_trans_35	PYGB PYGM	1.21e-05	3	38	2	IPR000811
Domain	PHOSPHORYLASE	PYGB PYGM	1.21e-05	3	38	2	PS00102
Domain	Phosphorylase	PYGB PYGM	1.21e-05	3	38	2	PF00343
Domain	Glycg_phsphrylas	PYGB PYGM	1.21e-05	3	38	2	IPR011833
Domain	CaM-bd_dom	KCNN2 KCNN4	2.41e-05	4	38	2	IPR004178
Domain	CaMBD	KCNN2 KCNN4	2.41e-05	4	38	2	SM01053
Domain	SK_channel	KCNN2 KCNN4	2.41e-05	4	38	2	PF03530
Domain	CaMBD	KCNN2 KCNN4	2.41e-05	4	38	2	PF02888
Domain	DUF4195	ZNF280A ZNF280C	2.41e-05	4	38	2	IPR025243
Domain	K_chnl_Ca-activ_SK	KCNN2 KCNN4	2.41e-05	4	38	2	IPR015449
Domain	DUF4195	ZNF280A ZNF280C	2.41e-05	4	38	2	PF13836
Domain	K_chnl_dom	KCNN2 KCNN4	8.26e-04	21	38	2	IPR013099
Domain	Ion_trans_2	KCNN2 KCNN4	8.26e-04	21	38	2	PF07885
Domain	SNF2_N	CHD8 EP400	1.92e-03	32	38	2	PF00176
Domain	SNF2_N	CHD8 EP400	1.92e-03	32	38	2	IPR000330
Domain	DNA/RNA_helicase_DEAH_CS	CHD8 EP400	2.30e-03	35	38	2	IPR002464
Domain	Sulfotransferase_dom	SULT1A4 SULT1A3	2.43e-03	36	38	2	IPR000863
Domain	Sulfotransfer_1	SULT1A4 SULT1A3	2.43e-03	36	38	2	PF00685
Domain	BROMODOMAIN_1	TRIM66 SP110	2.57e-03	37	38	2	PS00633
Domain	DEAH_ATP_HELICASE	CHD8 EP400	2.71e-03	38	38	2	PS00690
Domain	BROMODOMAIN_2	TRIM66 SP110	3.14e-03	41	38	2	PS50014
Domain	BROMO	TRIM66 SP110	3.30e-03	42	38	2	SM00297
Domain	Bromodomain	TRIM66 SP110	3.30e-03	42	38	2	IPR001487
Domain	-	TRIM66 SP110	3.30e-03	42	38	2	1.20.920.10
Domain	Zinc_finger_PHD-type_CS	TRIM66 SP110	7.73e-03	65	38	2	IPR019786
Domain	PHD	TRIM66 SP110	1.02e-02	75	38	2	PF00628
Domain	Znf_PHD-finger	TRIM66 SP110	1.13e-02	79	38	2	IPR019787
Pathway	KEGG_MEDICUS_ENV_FACTOR_PHIP_TO_DNA_ADDUCTS	SULT1A4 SULT1A3	2.77e-05	5	24	2	M47807
Pathway	KEGG_MEDICUS_REFERENCE_GLYCOGEN_DEGRADATION	PYGB PYGM	9.93e-05	9	24	2	M47621
Pathway	REACTOME_CA2_ACTIVATED_K_CHANNELS	KCNN2 KCNN4	9.93e-05	9	24	2	M26932
Pathway	KEGG_SULFUR_METABOLISM	SULT1A4 SULT1A3	2.14e-04	13	24	2	M18256
Pathway	REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS	PYGB PYGM	2.50e-04	14	24	2	M19193
Pathway	WP_ESTROGEN_METABOLISM	SULT1A4 SULT1A3	6.28e-04	22	24	2	MM15888
Pathway	REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES	SULT1A4 SULT1A3	6.88e-04	23	24	2	MM14597
Pathway	REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES	SULT1A4 SULT1A3	7.49e-04	24	24	2	M16289
Pathway	REACTOME_GLYCOGEN_METABOLISM	PYGB PYGM	8.14e-04	25	24	2	M27857
Pathway	REACTOME_PARACETAMOL_ADME	SULT1A4 SULT1A3	1.10e-03	29	24	2	M45015
Pathway	WP_GLYCOGEN_METABOLISM	PYGB PYGM	1.51e-03	34	24	2	MM15985
Pathway	REACTOME_PARACETAMOL_ADME	SULT1A4 SULT1A3	1.98e-03	39	24	2	MM15695
Pathway	WP_GLYCOGEN_SYNTHESIS_AND_DEGRADATION	PYGB PYGM	2.08e-03	40	24	2	M39595
Pathway	WP_RETINOL_METABOLISM	SULT1A4 SULT1A3	2.52e-03	44	24	2	MM15851
Pathway	KEGG_STARCH_AND_SUCROSE_METABOLISM	PYGB PYGM	3.50e-03	52	24	2	M14171
Pubmed	Human liver thermolabile phenol sulfotransferase: cDNA cloning, expression and characterization.	SULT1A4 SULT1A3	1.16e-06	2	38	2	8117269
Pubmed	Isoform-selective regulation of glycogen phosphorylase by energy deprivation and phosphorylation in astrocytes.	PYGB PYGM	1.16e-06	2	38	2	25130497
Pubmed	Impact of SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of phenylephrine and salbutamol by human SULT1A3 allozymes.	SULT1A4 SULT1A3	1.16e-06	2	38	2	31145702
Pubmed	Crystal structure of human catecholamine sulfotransferase.	SULT1A4 SULT1A3	1.16e-06	2	38	2	10543947
Pubmed	Effects of human SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of acetaminophen and opioid drugs by the cytosolic sulfotransferase SULT1A3.	SULT1A4 SULT1A3	1.16e-06	2	38	2	29705271
Pubmed	Phylogenomic approaches to common problems encountered in the analysis of low copy repeats: the sulfotransferase 1A gene family example.	SULT1A4 SULT1A3	1.16e-06	2	38	2	15752422
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	VAPB UTP20 FASTKD5 ATP8B4 CMYA5 PRC1 DAZAP1 SERPINH1 ZNF280C KIAA0586	2.14e-06	1425	38	10	30948266
Pubmed	Structure of human estrogen and aryl sulfotransferase gene. Two mRNA species issued from a single gene.	SULT1A4 SULT1A3	3.48e-06	3	38	2	7961757
Pubmed	Identification of two human brain aryl sulfotransferase cDNAs.	SULT1A4 SULT1A3	3.48e-06	3	38	2	8363592
Pubmed	A single amino acid, glu146, governs the substrate specificity of a human dopamine sulfotransferase, SULT1A3.	SULT1A4 SULT1A3	3.48e-06	3	38	2	9855620
Pubmed	Steroid sulfotransferases.	SULT1A4 SULT1A3	6.96e-06	4	38	2	8943792
Pubmed	Mapping of the phenol sulfotransferase gene (STP) to human chromosome 16p12.1-p11.2 and to mouse chromosome 7.	SULT1A4 SULT1A3	6.96e-06	4	38	2	8288252
Pubmed	A single mutation converts the nucleotide specificity of phenol sulfotransferase from PAP to AMP.	SULT1A4 SULT1A3	6.96e-06	4	38	2	12390022
Pubmed	Formation of hepatic DNA adducts by methyleugenol in mouse models: drastic decrease by Sult1a1 knockout and strong increase by transgenic human SULT1A1/2.	SULT1A4 SULT1A3	6.96e-06	4	38	2	24318996
Pubmed	Molecular cloning of cDNA encoding the phenol/aryl form of sulfotransferase (mSTp1) from mouse liver.	SULT1A4 SULT1A3	6.96e-06	4	38	2	8424956
Pubmed	Small-conductance calcium-activated K+ channels are expressed in pancreatic islets and regulate glucose responses.	KCNN2 KCNN4	6.96e-06	4	38	2	12882916
Pubmed	Bioactivation of food genotoxicants 5-hydroxymethylfurfural and furfuryl alcohol by sulfotransferases from human, mouse and rat: a comparative study.	SULT1A4 SULT1A3	6.96e-06	4	38	2	25370010
Pubmed	Decreased phenol sulfotransferase activities associated with hyperserotonemia in autism spectrum disorders.	SULT1A4 SULT1A3	6.96e-06	4	38	2	33414449
Pubmed	Interaction of the Brain-Selective Sulfotransferase SULT4A1 with Other Cytosolic Sulfotransferases: Effects on Protein Expression and Function.	SULT1A4 SULT1A3	6.96e-06	4	38	2	32152050
Pubmed	Arrhythmogenic calmodulin mutations impede activation of small-conductance calcium-activated potassium current.	KCNN2 KCNN4	1.16e-05	5	38	2	27165696
Pubmed	Identification of a new subfamily of sulphotransferases: cloning and characterization of canine SULT1D1.	SULT1A4 SULT1A3	1.16e-05	5	38	2	11389699
Pubmed	Hemoglobin adducts of furfuryl alcohol in genetically modified mouse models: Role of endogenous sulfotransferases 1a1 and 1d1 and transgenic human sulfotransferases 1A1/1A2.	SULT1A4 SULT1A3	1.16e-05	5	38	2	29908303
Pubmed	Determination of sulfotransferase forms involved in the metabolic activation of the genotoxicant 1-hydroxymethylpyrene using bacterially expressed enzymes and genetically modified mouse models.	SULT1A4 SULT1A3	1.16e-05	5	38	2	24802129
Pubmed	The effect of knockout of sulfotransferases 1a1 and 1d1 and of transgenic human sulfotransferases 1A1/1A2 on the formation of DNA adducts from furfuryl alcohol in mouse models.	SULT1A4 SULT1A3	1.16e-05	5	38	2	25053625
Pubmed	Human SULT1A3 pharmacogenetics: gene duplication and functional genomic studies.	SULT1A4 SULT1A3	1.74e-05	6	38	2	15358107
Pubmed	Cytosolic sulfotransferase 1A3 is induced by dopamine and protects neuronal cells from dopamine toxicity: role of D1 receptor-N-methyl-D-aspartate receptor coupling.	SULT1A4 SULT1A3	2.43e-05	7	38	2	24136195
Pubmed	The mouse Plk gene: structural characterization, chromosomal localization and identification of a processed Plk pseudogene.	SULT1A4 SULT1A3	2.43e-05	7	38	2	9370299
Pubmed	Chromosomal localization of three vacuolar-H+ -ATPase 16 kDa subunit (ATP6V0C) genes in the murine genome.	SULT1A4 SULT1A3	2.43e-05	7	38	2	12438748
Pubmed	Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain.	SULT1A4 SULT1A3	3.24e-05	8	38	2	10594240
Pubmed	International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels.	KCNN2 KCNN4	3.24e-05	8	38	2	16382103
Pubmed	The gene encoding the heart/muscle isoform of cytochrome c oxidase subunit VIII maps to mouse chromosome 7.	SULT1A4 SULT1A3	4.16e-05	9	38	2	9166597
Pubmed	Chromosomal localization of the mouse genes encoding the ERK1 and ERK2 isoforms of MAP kinases.	SULT1A4 SULT1A3	4.16e-05	9	38	2	9060415
Pubmed	Msx3: a novel murine homologue of the Drosophila msh homeobox gene restricted to the dorsal embryonic central nervous system.	SULT1A4 SULT1A3	4.16e-05	9	38	2	8887328
Pubmed	Structure of the human gene (COX6A2) for the heart/muscle isoform of cytochrome c oxidase subunit VIa and its chromosomal location in humans, mice, and cattle.	SULT1A4 SULT1A3	4.16e-05	9	38	2	9177785
Pubmed	Ethanol sulfation by the human cytosolic sulfotransferases: a systematic analysis.	SULT1A4 SULT1A3	4.16e-05	9	38	2	23207770
Pubmed	Molecular characterization and mapping of murine genes encoding three members of the stefin family of cysteine proteinase inhibitors.	SULT1A4 SULT1A3	4.16e-05	9	38	2	8468045
Pubmed	Inhibitory effects of kynurenic acid, a tryptophan metabolite, and its derivatives on cytosolic sulfotransferases.	SULT1A4 SULT1A3	4.16e-05	9	38	2	19548878
Pubmed	Genome-wide association study of retinopathy in individuals without diabetes.	GSDMC PCDH18	5.20e-05	10	38	2	23393555
Pubmed	Rat phenol-preferring sulfotransferase genes (Stp and Stp2): localization to mouse chromosomes 7 and 17.	SULT1A4 SULT1A3	5.20e-05	10	38	2	7601475
Pubmed	Localization of the murine cholecystokinin A and B receptor genes.	SULT1A4 SULT1A3	6.35e-05	11	38	2	7613026
Pubmed	Sulfotransferases in the bioactivation of xenobiotics.	SULT1A4 SULT1A3	6.35e-05	11	38	2	11154739
Pubmed	Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes.	SULT1A4 SULT1A3	6.35e-05	11	38	2	9034160
Pubmed	Sulfotransferases: genetics and role in toxicology.	SULT1A4 SULT1A3	6.35e-05	11	38	2	10720750
Pubmed	Tbx6, a mouse T-Box gene implicated in paraxial mesoderm formation at gastrulation.	SULT1A4 SULT1A3	6.35e-05	11	38	2	8954725
Pubmed	Identification of four chromosomal loci determining obesity in a multifactorial mouse model.	SULT1A4 SULT1A3	7.62e-05	12	38	2	7706460
Pubmed	PHR1 encodes an abundant, pleckstrin homology domain-containing integral membrane protein in the photoreceptor outer segments.	SULT1A4 SULT1A3	9.00e-05	13	38	2	10585447
Pubmed	WD repeat-containing protein 5 (WDR5) localizes to the midbody and regulates abscission.	PRC1 CHMP1B	9.00e-05	13	38	2	25666610
Pubmed	Structural and chemical profiling of the human cytosolic sulfotransferases.	SULT1A4 SULT1A3	9.00e-05	13	38	2	17425406
Pubmed	HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation.	KCNN2 KCNN4	1.05e-04	14	38	2	10758170
Pubmed	Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.	UTP20 ZNF407	1.05e-04	14	38	2	24962325
Pubmed	Localization of the muscle, liver, and brain glycogen phosphorylase genes on linkage maps of mouse chromosomes 19, 12, and 2, respectively.	PYGB PYGM	1.21e-04	15	38	2	2575583
Pubmed	cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein.	SULT1A4 SULT1A3	1.21e-04	15	38	2	1741163
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	VAPB PRC1 DAZAP1 EP400 SP110	1.29e-04	453	38	5	29656893
Pubmed	Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples.	SULT1A4 SULT1A3	1.76e-04	18	38	2	20056724
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	MED12L CHD8 PCDH18	1.86e-04	101	38	3	10997877
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TRIM66 ZNF407 ATP8B4 PCDH18 KIAA0586	1.91e-04	493	38	5	15368895
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	MED12L ZNF407 PYGM CMYA5 RYR1	1.99e-04	497	38	5	23414517
Pubmed	Inactivation of Wt1 causes pre-granulosa cell to steroidogenic cell transformation and defect of ovary development†.	SULT1A4 SULT1A3	2.41e-04	21	38	2	32301970
Pubmed	USP7 Regulates Cytokinesis through FBXO38 and KIF20B.	CHD8 EP400 PRRC2B	2.80e-04	116	38	3	30804394
Pubmed	Analysis of a lung defect in autophagy-deficient mouse strains.	PYGB PYGM	3.72e-04	26	38	2	24275123
Pubmed	Characterising the dynamics of placental glycogen stores in the mouse.	PYGB PYGM	4.63e-04	29	38	2	32798765
Pubmed	Interaction network of human early embryonic transcription factors.	SOX5 CHD8 EP400 PRRC2B	5.74e-04	351	38	4	38297188
Pubmed	Joubert Syndrome	TMEM67 KIAA0586	6.38e-04	34	38	2	20301500
Pubmed	Radial glia require PDGFD-PDGFRβ signalling in human but not mouse neocortex.	PRC1 SP110	6.38e-04	34	38	2	25391964
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	PYGB UTP20 CHD8 SERPINH1 PRRC2B	6.91e-04	653	38	5	22586326
Pubmed	Ion channel expression in the developing enteric nervous system.	KCNN2 KCNN4	7.56e-04	37	38	2	25798587
Pubmed	The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.	FASTKD5 PRC1 EP400 SERPINH1	9.00e-04	396	38	4	26687479
Pubmed	Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression.	PYGB PYGM SERPINH1	9.13e-04	174	38	3	29669786
GeneFamily	Glycogen phosphorylases	PYGB PYGM	5.50e-06	3	25	2	437
GeneFamily	Potassium calcium-activated channels	KCNN2 KCNN4	2.74e-05	6	25	2	255
GeneFamily	Sulfotransferases, cytosolic	SULT1A4 SULT1A3	1.65e-04	14	25	2	762
GeneFamily	PHD finger proteins	TRIM66 SP110	6.82e-03	90	25	2	88
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM66 CMYA5	7.58e-03	95	25	2	59
ToppCell	droplet-Heart-nan-3m-Hematologic-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MED12L KCNN4 ATP8B4 RYR1	6.11e-06	140	38	4	ab90f6f30d89761687f8836e3d327d143ce49ed4
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TRIM66 ZBTB12 GSDMC TTC6	1.51e-05	176	38	4	87de432c680b80555342afac864599bbc002c040
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-B\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ZNF280A PYGB SULT1A4 SULT1A3	1.75e-05	183	38	4	dc8220ac8879b118a4ef64ce6417d6d3874143ca
ToppCell	droplet-Heart-nan-18m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MED12L PYGB PYGM CMYA5	2.12e-05	192	38	4	0bf99e029a06151092db1e8a0dcb45f4e688e771
ToppCell	droplet-Heart-nan-18m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MED12L PYGB PYGM CMYA5	2.12e-05	192	38	4	d766221acfce30cbf2c60b3ae40f6744968b952c
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KCNN4 CMYA5 GSDMC TTC6	2.16e-05	193	38	4	a5695ce2e24a62026ae28f3dea07ca4a435206b8
Drug	GlcMan	PYGB PYGM MGAT4C	4.28e-08	5	38	3	CID000152120
Drug	adenylylsulfate	KCNN2 PYGB PYGM SULT1A4 SULT1A3	1.27e-07	72	38	5	CID000000228
Drug	Gvapspat amide	PYGB PYGM RYR1	1.92e-06	15	38	3	CID000125015
Drug	3,5-dimethylphenyl isocyanate	PYGB PYGM	8.13e-06	3	38	2	CID000521488
Drug	3'-FFdUrd	PYGB PYGM	8.13e-06	3	38	2	CID000072260
Drug	5-ethyl-4-hydroxy-2-methyl-3(2H)-furanone	PYGB PYGM	8.13e-06	3	38	2	CID000093111
Drug	2',3',4',5,5'-pentachloro-2-biphenylol	PYGB PYGM	8.13e-06	3	38	2	CID000119518
Drug	adenosine-5'-chloromethylphosphonate	PYGB PYGM	8.13e-06	3	38	2	CID000191554
Drug	AC1L8XK3	PYGB PYGM	8.13e-06	3	38	2	CID000409735
Drug	N-acetyl-N'-beta-D-glucopyranosyl urea	PYGB PYGM	8.13e-06	3	38	2	CID000446801
Drug	hydan	PYGB PYGM	8.13e-06	3	38	2	CID000008360
Drug	EHMF	PYGB PYGM	8.13e-06	3	38	2	CID000033931
Drug	NSC758405	PYGB PYGM	8.13e-06	3	38	2	CID000003201
Drug	3,5-dinitrophenyl phosphate	PYGB PYGM	8.13e-06	3	38	2	CID000151920
Drug	riboflavin tetraacetate	PYGB PYGM	8.13e-06	3	38	2	CID000094186
Drug	5'-deoxy-5'-fluoro-5'-(methylthio)adenosine	PYGB PYGM	8.13e-06	3	38	2	CID000147839
Drug	pyridoxal phosphoglucose	PYGB PYGM	8.13e-06	3	38	2	CID000196007
Drug	pyridoxal 5'-methylenephosphonate	PYGB PYGM	8.13e-06	3	38	2	CID003082249
Drug	2,5-dimethyl-3-furanone	PYGB PYGM	8.13e-06	3	38	2	CID000085730
Drug	Plp 5'-mpa	PYGB PYGM	8.13e-06	3	38	2	CID003082151
Drug	3,5-dinitrophenol	PYGB PYGM	8.13e-06	3	38	2	CID000011459
Drug	glucose-1,2-cyclic phosphate	PYGB PYGM	8.13e-06	3	38	2	CID000191723
Drug	1,2-dideoxy-d-arabino-hex-1-enopyranose	PYGB PYGM MGAT4C	9.62e-06	25	38	3	CID000089465
Drug	LB-2	PYGB PYGM MGAT4C	1.37e-05	28	38	3	CID000129887
Drug	galocitabine	PYGB PYGM	1.62e-05	4	38	2	CID000065950
Drug	uric acid riboside	PYGB PYGM	1.62e-05	4	38	2	CID000164933
Drug	pseudo-dl-glucose	PYGB PYGM	1.62e-05	4	38	2	CID000125259
Drug	2,5-anhydro-D-mannitol 1-phosphate	PYGB PYGM	1.62e-05	4	38	2	CID000189134
Drug	AC1LAMW2	PYGB PYGM	1.62e-05	4	38	2	CID000491364
Drug	FdUrd-C8	PYGB PYGM	1.62e-05	4	38	2	CID000094262
Drug	BCIp4A	PYGB PYGM	1.62e-05	4	38	2	CID000192417
Drug	Mem-CC	PYGB PYGM	1.62e-05	4	38	2	CID003081269
Drug	pyridoxal diphosphate	PYGB PYGM	1.62e-05	4	38	2	CID000125696
Drug	5-deoxyribose-1-phosphate	PYGB PYGM	1.62e-05	4	38	2	CID000135786
Drug	3'-chloromethotrexate	PYGB PYGM	1.62e-05	4	38	2	CID000097703
Drug	ingliforib	PYGB PYGM	1.62e-05	4	38	2	CID006451325
Drug	barium hydroxide	SULT1A4 SULT1A3 MGAT4C	1.87e-05	31	38	3	CID000028387
Drug	Antipyrine, 4-hydroxy [1672-63-5]; Up 200; 19.6uM; PC3; HG-U133A	PYGB EP400 SERPINH1 SP110 PRRC2B	1.93e-05	199	38	5	1915_UP
Drug	AC1L1AOE	PYGB PYGM CTH	2.06e-05	32	38	3	CID000001078
Drug	heptulose-2-P	PYGB PYGM	2.70e-05	5	38	2	CID000124823
Drug	m-anisidine	PYGB PYGM	2.70e-05	5	38	2	CID000010824
Drug	indirubin-5-sulphonate	PYGB PYGM	2.70e-05	5	38	2	CID005288641
Drug	6-FPLP	PYGB PYGM	2.70e-05	5	38	2	CID000146246
Drug	gluconohydroximo-1,5-lactone	PYGB PYGM	2.70e-05	5	38	2	CID009576855
Drug	2-hydroxypropylphosphonate	PYGB PYGM	2.70e-05	5	38	2	CID000441028
Drug	DHPBU	PYGB PYGM	2.70e-05	5	38	2	CID000125914
Drug	6-FDPL	PYGB PYGM	2.70e-05	5	38	2	CID000129578
Drug	AC1O3M08	PYGB PYGM	2.70e-05	5	38	2	CID006331955
Drug	AC1LCUXJ	PYGB PYGM	2.70e-05	5	38	2	CID000656425
Drug	6-amino-5-bromouracil	PYGB PYGM	2.70e-05	5	38	2	CID000080578
Drug	5'-isobutylthioinosine	PYGB PYGM	2.70e-05	5	38	2	CID003080910
Drug	etafenone	PYGB PYGM	2.70e-05	5	38	2	CID000003275
Drug	ddEtUrd	PYGB PYGM	2.70e-05	5	38	2	CID000451452
Drug	5-trifluoromethyl-2'-deoxycytidine	PYGB PYGM	2.70e-05	5	38	2	CID000125618
Drug	3'-O-methylpyridoxal 5'-phosphate	PYGB PYGM	2.70e-05	5	38	2	CID003082179
Drug	U66985	PYGB PYGM	2.70e-05	5	38	2	CID000127224
Drug	2,2-dimethyl-3-hydroxybutyric acid	PYGB PYGM	4.05e-05	6	38	2	CID000152984
Drug	CV-araU	PYGB PYGM	4.05e-05	6	38	2	CID006441877
Drug	EdUMP	PYGB PYGM	4.05e-05	6	38	2	CID003085112
Drug	2-thiothymidine	PYGB PYGM	4.05e-05	6	38	2	CID003005944
Drug	5'-deoxy-5'-chloroformycin	PYGB PYGM	4.05e-05	6	38	2	CID000126430
Drug	NSC-97433	PYGB PYGM	4.05e-05	6	38	2	CID000001803
Drug	5-n-propylthioadenosine	PYGB PYGM	4.05e-05	6	38	2	CID000656428
Drug	AzddCyd	PYGB PYGM	4.05e-05	6	38	2	CID000451374
Drug	5-Ffdru	PYGB PYGM	4.05e-05	6	38	2	CID000065561
Drug	AR-L57	PYGB PYGM	4.05e-05	6	38	2	CID000156890
Drug	Carbocyclic Ivdu	PYGB PYGM	4.05e-05	6	38	2	CID006439191
Drug	Carbocyclic Bvdc	PYGB PYGM	4.05e-05	6	38	2	CID006438602
Drug	DNPP	PYGB PYGM	4.05e-05	6	38	2	CID000067056
Drug	5-chloro-indole-2-carboxylic acid	PYGB PYGM	4.05e-05	6	38	2	CID000082693
Drug	maltoheptose	PYGB PYGM DPP8	4.06e-05	40	38	3	CID003037125
Drug	alpha-(fluoromethyl)dehydroornithine	PYGB PYGM	5.67e-05	7	38	2	CID006439607
Drug	1 Gpt	PYGB PYGM	5.67e-05	7	38	2	CID000101247
Drug	6-fluoropyridoxal	PYGB PYGM	5.67e-05	7	38	2	CID003080803
Drug	formycins	PYGB PYGM	5.67e-05	7	38	2	CID000512867
Drug	luciferyl sulfate	SULT1A4 SULT1A3	5.67e-05	7	38	2	CID011953812
Drug	Promonta	PYGB PYGM	5.67e-05	7	38	2	CID000108494
Drug	2',3'-dideoxy-3'-fluorocytidine	PYGB PYGM	5.67e-05	7	38	2	CID000356019
Drug	dopamine-4-O-sulfate	SULT1A4 SULT1A3	5.67e-05	7	38	2	CID000123932
Drug	2-naphthylsulfate	SULT1A4 SULT1A3	5.67e-05	7	38	2	CID000074428
Drug	heptenitol	PYGB PYGM	5.67e-05	7	38	2	CID000188267
Drug	5'-methylthioinosine	PYGB PYGM	5.67e-05	7	38	2	CID000161214
Drug	AC1L3372	PYGB PYGM	5.67e-05	7	38	2	CID000108025
Drug	hydantocidin	PYGB PYGM	5.67e-05	7	38	2	CID000125429
Drug	2-iodo-4-azidophenol	SULT1A4 SULT1A3	5.67e-05	7	38	2	CID003035977
Drug	2-iodophenol	SULT1A4 SULT1A3	7.55e-05	8	38	2	CID000010784
Drug	dopamine 3-O-sulfate	SULT1A4 SULT1A3	7.55e-05	8	38	2	CID000122136
Drug	6-methylpurine	PYGB PYGM	7.55e-05	8	38	2	CID005287547
Drug	amorphin	PYGB PYGM	7.55e-05	8	38	2	CID000122792
Drug	Etafenone [inn]	PYGB PYGM	7.55e-05	8	38	2	CID000066659
Drug	AC1NUVX5	PYGB PYGM	7.55e-05	8	38	2	CID005461894
Drug	6-anilino-2-thiouracil	SULT1A4 SULT1A3	7.55e-05	8	38	2	CID003037707
Drug	amylopectin	PYGB PYGM DPP8	8.96e-05	52	38	3	CID000439207
Drug	Pyridoxal Phosphate	PYGB PYGM CTH	9.49e-05	53	38	3	DB00114
Drug	5'-iodo-5'-deoxyadenosine	PYGB PYGM	9.69e-05	9	38	2	CID000107502
Drug	6-benzyl-2-thiouracil	PYGB PYGM	9.69e-05	9	38	2	CID000685814
Drug	5'-methylthiotubercidin	PYGB PYGM	9.69e-05	9	38	2	CID000188350
Drug	alpha-maltosyl fluoride	PYGB PYGM	9.69e-05	9	38	2	CID000194237
Drug	5-Iodoribose 1-phosphate	PYGB PYGM	9.69e-05	9	38	2	CID003035973
Drug	8-azidoadenosine 5'-monophosphate	PYGB PYGM	1.21e-04	10	38	2	CID000124726
Disease	colorectal cancer, inflammatory bowel disease	ATP8B4 SP110	2.44e-04	19	36	2	EFO_0003767, MONDO_0005575
Disease	Joubert syndrome 1	TMEM67 KIAA0586	3.00e-04	21	36	2	C4551568
Disease	Familial aplasia of the vermis	TMEM67 KIAA0586	6.16e-04	30	36	2	C0431399
Disease	uric acid measurement	SOX5 PYGB PYGM DAZAP1 PRRC2B	8.24e-04	610	36	5	EFO_0004761
Disease	coronary aneurysm	KCNN2 TTC6	8.40e-04	35	36	2	EFO_1000881
Disease	age at onset, alcohol dependence	UTP20 ZNF407	1.21e-03	42	36	2	EFO_0004847, MONDO_0007079

Protein segments in the cluster

Peptide	Gene	Start	Entry
KFMNHMKHHLEFEKQ	ZNF280A	311	P59817
FQGNMMDFLAFKKKH	EP400	396	Q96L91
FKTKMAQMRHFFHED	CHD8	701	Q9HCK8
FHFSDIMIQKHKADM	GSDMC	81	Q9BYG8
MEKHFKNGMAVAQFL	CTH	266	P32929
FQFFDHHLMESIKMG	ATP8B4	446	Q8TF62
VNMHFHDIMGKKVEV	DAZAP1	171	Q96EP5
MHQMNAKMHFRFVFA	PCDH18	1	Q9HCL0
MSNMEKHLFNLKFAA	CHMP1B	1	Q7LBR1
MFKFHQMKHIFEILD	MGAT4C	1	Q9UBM8
QHEKEHFEDSMKKAF	POC5	341	Q8NA72
LAFHMFQEGMLEKHE	MED12L	236	Q86YW9
FNKAEKHVHNFMMDI	KCNN4	291	O15554
KAEKHVHNFMMDTQL	KCNN2	401	Q9H2S1
FSQFSLVKQHFMKMH	ATMIN	146	O43313
KMFRFTHVDHINFMK	FASTKD5	361	Q7L8L6
KKMEFLHEQMVHFLQ	CMYA5	3616	Q8N3K9
MAKAPHDFMFVKRND	DPP8	76	Q6V1X1
FLHVFAHMMMKLAQD	RYR1	3991	P21817
MMNKFLGSFIDHVHK	TMEM67	876	Q5HYA8
EMDFFENMKHIQIHR	UTP20	1571	O75691
EHSKAFMVNGQKFME	PRC1	416	O43663
DEKFHHKMVDNRGFM	SERPINH1	211	P50454
MNHFHQRRELDFKHM	SNX33	531	Q8WV41
RAMEEALFQHFMHQK	SP110	6	Q9HB58
DFMVQHTSFKEMKKN	SULT1A4	221	P0DMN0
DFMVQHTSFKEMKKN	SULT1A3	221	P0DMM9
EKLVFHMRAQHFIFM	ZBTB12	346	Q9Y330
VIHEFMGHKQNAMKD	TTC6	356	Q86TZ1
DIVNMLMHHDRFKVF	PYGM	761	P11217
DIVNMLMHHDRFKVF	PYGB	761	P11216
MEMKGFHFADSKQNV	PRRC2B	2131	Q5JSZ5
KQNEEGKFSHAMMDF	SOX5	511	P35711
NEKSKHKFMVQSMFA	VAPB	81	O95292
FMNHMKHHLELEKQN	ZNF280C	331	Q8ND82
INLRDHMKEKHNMHF	ZNF407	601	Q9C0G0
DIMHHKFELEEMQKD	TRIM66	506	O15016
HDHEKQMNVFMEQHI	KIAA0586	226	Q9BVV6