Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	olfactory receptor activity	OR4M1 OR2Y1 OR4D1 OR10G6 OR4M2 OR4K5 OR4N2 OR4K2 OR2T6 OR4N5 OR4D5 OR4N4 OR11H7 OR4D9	2.33e-14	431	38	14	GO:0004984
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR4M1 OR2Y1 OR4D1 OR10G6 OR4M2 SMO PRLHR OR4K5 OR4N2 OR4K2 OR2T6 OR4N5 OR4D5 OR4N4 OR11H7 OR4D9	1.70e-12	884	38	16	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR4M1 OR2Y1 OR4D1 OR10G6 OR4M2 SMO PRLHR OR4K5 OR4N2 OR4K2 OR2T6 OR4N5 OR4D5 OR4N4 OR11H7 OR4D9 TLR3	8.91e-11	1353	38	17	GO:0004888
GeneOntologyMolecularFunction	mannosyltransferase activity	DPY19L2 DPY19L2P2 DPY19L1	2.02e-05	28	38	3	GO:0000030
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR4M1 OR2Y1 OR4D1 OR10G6 OR4M2 OR4K5 OR4N2 OR4K2 OR2T6 OR4N5 OR4D5 OR4N4 OR11H7 OR4D9	6.33e-15	432	36	14	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR4M1 OR2Y1 OR4D1 OR10G6 OR4M2 OR4K5 OR4N2 OR4K2 OR2T6 OR4N5 OR4D5 OR4N4 OR11H7 OR4D9	1.74e-14	465	36	14	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR4M1 OR2Y1 OR4D1 OR10G6 OR4M2 OR4K5 OR4N2 OR4K2 OR2T6 OR4N5 OR4D5 OR4N4 OR11H7 OR4D9	3.10e-14	485	36	14	GO:0050907
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR4M1 OR2Y1 OR4D1 OR10G6 OR4M2 OR4K5 OR4N2 OR4K2 OR2T6 OR4N5 OR4D5 OR4N4 OR11H7 OR4D9	8.93e-14	524	36	14	GO:0009593
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR4M1 OR2Y1 OR4D1 OR10G6 OR4M2 OR4K5 OR4N2 OR4K2 OR2T6 OR4N5 OR4D5 OR4N4 OR11H7 OR4D9	1.60e-13	547	36	14	GO:0007606
GeneOntologyBiologicalProcess	detection of stimulus	OR4M1 OR2Y1 OR4D1 OR10G6 OR4M2 SMO OR4K5 OR4N2 OR4K2 OR2T6 OR4N5 OR4D5 OR4N4 OR11H7 OR4D9	3.53e-13	722	36	15	GO:0051606
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR4M1 OR2Y1 OR4D1 OR10G6 OR4M2 OR4K5 OR4N2 OR4K2 OR2T6 OR4N5 OR4D5 OR4N4 OR11H7 OR4D9	3.73e-13	582	36	14	GO:0050906
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR4M1 OR2Y1 OR4D1 OR10G6 OR4M2 SMO PRLHR OR4K5 OR4N2 OR4K2 OR2T6 OR4N5 OR4D5 OR4N4 OR11H7 OR4D9	3.53e-10	1395	36	16	GO:0007186
GeneOntologyBiologicalProcess	sensory perception	OR4M1 OR2Y1 OR4D1 OR10G6 OR4M2 OR4K5 OR4N2 OR4K2 OR2T6 OR4N5 OR4D5 OR4N4 OR11H7 OR4D9	1.25e-09	1072	36	14	GO:0007600
GeneOntologyBiologicalProcess	protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan	DPY19L2 DPY19L2P2 DPY19L1	9.73e-08	6	36	3	GO:0018406
GeneOntologyBiologicalProcess	peptidyl-tryptophan modification	DPY19L2 DPY19L2P2 DPY19L1	9.73e-08	6	36	3	GO:0018211
GeneOntologyBiologicalProcess	protein C-linked glycosylation	DPY19L2 DPY19L2P2 DPY19L1	9.73e-08	6	36	3	GO:0018103
GeneOntologyBiologicalProcess	protein C-linked glycosylation via tryptophan	DPY19L2 DPY19L2P2 DPY19L1	9.73e-08	6	36	3	GO:0018317
GeneOntologyBiologicalProcess	protein mannosylation	DPY19L2 DPY19L2P2 DPY19L1	1.09e-05	25	36	3	GO:0035268
GeneOntologyBiologicalProcess	mannosylation	DPY19L2 DPY19L2P2 DPY19L1	1.23e-05	26	36	3	GO:0097502
GeneOntologyBiologicalProcess	positive regulation of response to food	OR4M1 OR4M2	6.19e-05	7	36	2	GO:0032097
GeneOntologyBiologicalProcess	positive regulation of appetite	OR4M1 OR4M2	6.19e-05	7	36	2	GO:0032100
GeneOntologyBiologicalProcess	positive regulation of response to nutrient levels	OR4M1 OR4M2	8.24e-05	8	36	2	GO:0032109
GeneOntologyBiologicalProcess	positive regulation of cilium-dependent cell motility	OR4M1 OR4M2	4.45e-04	18	36	2	GO:2000155
GeneOntologyBiologicalProcess	positive regulation of flagellated sperm motility	OR4M1 OR4M2	4.45e-04	18	36	2	GO:1902093
GeneOntologyBiologicalProcess	positive regulation of cilium movement	OR4M1 OR4M2	4.97e-04	19	36	2	GO:0003353
GeneOntologyBiologicalProcess	regulation of response to food	OR4M1 OR4M2	1.01e-03	27	36	2	GO:0032095
GeneOntologyBiologicalProcess	regulation of flagellated sperm motility	OR4M1 OR4M2	1.09e-03	28	36	2	GO:1901317
GeneOntologyBiologicalProcess	viral release from host cell	ZNF502 DDB1	1.25e-03	30	36	2	GO:0019076
GeneOntologyBiologicalProcess	regulation of appetite	OR4M1 OR4M2	1.25e-03	30	36	2	GO:0032098
GeneOntologyBiologicalProcess	exit from host cell	ZNF502 DDB1	1.25e-03	30	36	2	GO:0035891
GeneOntologyCellularComponent	nuclear inner membrane	TMEM120B DPY19L2 DPY19L2P2 DPY19L1	3.93e-06	59	38	4	GO:0005637
MousePheno	abnormal sperm individualization	DPY19L2 DPY19L2P2	1.05e-05	4	19	2	MP:0031372
MousePheno	decreased hepatic glucose production	OR4M1 OR4M2	3.66e-05	7	19	2	MP:0020103
MousePheno	multiflagellated sperm	DPY19L2 DPY19L2P2	1.58e-04	14	19	2	MP:0009839
MousePheno	abnormal hepatic glucose production	OR4M1 OR4M2	2.08e-04	16	19	2	MP:0020101
MousePheno	elongated manchette	DPY19L2 DPY19L2P2	2.35e-04	17	19	2	MP:0031386
MousePheno	ectopic manchette	DPY19L2 DPY19L2P2	2.95e-04	19	19	2	MP:0009377
MousePheno	decreased liver cholesterol level	OR4M1 OR4M2	5.58e-04	26	19	2	MP:0010026
MousePheno	absent sperm mitochondrial sheath	DPY19L2 DPY19L2P2	6.48e-04	28	19	2	MP:0009833
MousePheno	abnormal susceptibility to weight gain	OR4M1 PAQR9 OR4M2 PRLHR	6.98e-04	309	19	4	MP:0011117
MousePheno	improved glucose tolerance	OR4M1 OR2Y1 OR4M2 SLC29A1	7.50e-04	315	19	4	MP:0005292
MousePheno	decreased food intake	OR4M1 OR4M2 PRLHR	7.95e-04	137	19	3	MP:0011940
Domain	Olfact_rcpt	OR4M1 OR2Y1 OR4D1 OR10G6 OR4M2 OR4K5 OR4N2 OR4K2 OR2T6 OR4N5 OR4D5 OR4N4 OR4D9	1.94e-13	393	36	13	IPR000725
Domain	7tm_1	OR4M1 OR2Y1 OR4D1 OR10G6 OR4M2 PRLHR OR4K5 OR4N2 OR4K2 OR2T6 OR4N5 OR4D5 OR4N4 OR4D9	1.07e-11	677	36	14	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR4M1 OR2Y1 OR4D1 OR10G6 OR4M2 PRLHR OR4K5 OR4N2 OR4K2 OR2T6 OR4N5 OR4D5 OR4N4 OR4D9	1.26e-11	685	36	14	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR4M1 OR2Y1 OR4D1 OR10G6 OR4M2 PRLHR OR4K5 OR4N2 OR4K2 OR2T6 OR4N5 OR4D5 OR4N4 OR4D9	1.41e-11	691	36	14	PS50262
Domain	GPCR_Rhodpsn	OR4M1 OR2Y1 OR4D1 OR10G6 OR4M2 PRLHR OR4K5 OR4N2 OR4K2 OR2T6 OR4N5 OR4D5 OR4N4 OR4D9	1.44e-11	692	36	14	IPR000276
Domain	GPCR_Rhodpsn_7TM	OR4M1 OR2Y1 OR4D1 OR4M2 PRLHR OR4K5 OR4N2 OR4K2 OR2T6 OR4N5 OR4D5 OR4N4 OR4D9	1.57e-10	670	36	13	IPR017452
Domain	Dpy19	DPY19L2 DPY19L1	2.16e-05	4	36	2	PF10034
Domain	Dpy-19/Dpy-19-like	DPY19L2 DPY19L1	2.16e-05	4	36	2	IPR018732
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR4M1 OR2Y1 OR4D1 OR10G6 OR4M2 OR4K5 OR4N2 OR4K2 OR2T6 OR4N5 OR4D5 OR4N4 OR11H7 OR4D9	1.64e-14	417	29	14	M4072
Pathway	REACTOME_SENSORY_PERCEPTION	OR4M1 OR2Y1 OR4D1 OR10G6 OR4M2 OR4K5 OR4N2 OR4K2 OR2T6 OR4N5 OR4D5 OR4N4 OR11H7 OR4D9	5.21e-12	636	29	14	M41834
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR4M1 OR2Y1 OR4D1 OR4M2 OR4K5 OR4N2 OR4K2 OR2T6 OR4N5 OR4D5 OR4N4 OR4D9	5.60e-12	389	29	12	M14091
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR4M1 OR2Y1 OR4D1 OR10G6 OR4M2 OR4K5 OR4N2 OR4K2 OR2T6 OR4N5 OR4D5 OR11H7	2.74e-15	340	40	12	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR4M1 OR2Y1 OR4D1 OR10G6 OR4M2 OR4K5 OR4N2 OR4K2 OR2T6 OR4N5 OR4D5 OR11H7	2.74e-15	340	40	12	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR4M1 OR2Y1 OR4D1 OR10G6 OR4M2 OR4K5 OR4N2 OR4K2 OR2T6 OR4N5 OR4D5 OR11H7	3.05e-15	343	40	12	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR4M1 OR2Y1 OR4D1 OR10G6 OR4M2 OR4K5 OR4N2 OR4K2 OR2T6 OR4N5 OR4D5 OR11H7	3.38e-15	346	40	12	14611657
Pubmed	The human olfactory receptor gene family.	OR4M1 OR2Y1 OR4D1 OR10G6 OR4M2 OR4K5 OR4N2 OR4K2 OR4N5 OR4D5 OR4N4 OR11H7 OR4D9	2.22e-14	541	40	13	14983052
Pubmed	Absence of Dpy19l2, a new inner nuclear membrane protein, causes globozoospermia in mice by preventing the anchoring of the acrosome to the nucleus.	DPY19L2 DPY19L2P2	1.29e-06	2	40	2	22764053
Pubmed	Dpy19l2-deficient globozoospermic sperm display altered genome packaging and DNA damage that compromises the initiation of embryo development.	DPY19L2 DPY19L2P2	1.29e-06	2	40	2	25354700
Pubmed	Subcellular localization of phospholipase Cζ in human sperm and its absence in DPY19L2-deficient sperm are consistent with its role in oocyte activation.	DPY19L2 DPY19L2P2	1.29e-06	2	40	2	25354701
Pubmed	Dpy19l1, a multi-transmembrane protein, regulates the radial migration of glutamatergic neurons in the developing cerebral cortex.	DPY19L2 DPY19L2P2 DPY19L1	1.58e-06	20	40	3	22028030
Pubmed	The Asprosin-OLFR734 hormonal signaling axis modulates male fertility.	OR4M1 OR4M2	3.87e-06	3	40	2	31798959
Pubmed	Dynamics of Sun5 localization during spermatogenesis in wild type and Dpy19l2 knock-out mice indicates that Sun5 is not involved in acrosome attachment to the nuclear envelope.	DPY19L2 DPY19L2P2	3.87e-06	3	40	2	25775128
Pubmed	Duplication and relocation of the functional DPY19L2 gene within low copy repeats.	DPY19L2 DPY19L2P2	3.87e-06	3	40	2	16526957
Pubmed	The Asprosin-OLFR734 module regulates appetitive behaviors.	OR4M1 OR4M2	3.87e-06	3	40	2	32337066
Pubmed	OLFR734 Mediates Glucose Metabolism as a Receptor of Asprosin.	OR4M1 OR4M2	7.73e-06	4	40	2	31230984
Pubmed	FAM209 associates with DPY19L2, and is required for sperm acrosome biogenesis and fertility in mice.	DPY19L2 DPY19L2P2	1.29e-05	5	40	2	34471926
Pubmed	Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons.	OR4D1 OR4K2 OR4N4C	2.07e-05	46	40	3	32126975
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR2Y1 OR4D1 OR2T6 OR11H7	1.17e-04	219	40	4	12213199
Pubmed	Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.	SMO PRLHR	3.80e-04	25	40	2	28154160
Cytoband	14q11.2	OR4M1 OR4K5 OR4N2 OR4K2 OR4N5 OR11H7	1.15e-08	180	40	6	14q11.2
Cytoband	Ensembl 112 genes in cytogenetic band chr14q11	OR4M1 OR4K5 OR4N2 OR4K2 OR4N5 OR11H7	4.27e-07	332	40	6	chr14q11
Cytoband	11q24.1	OR10G6 OR4D5	4.84e-04	37	40	2	11q24.1
Cytoband	Ensembl 112 genes in cytogenetic band chr15q11	OR4M2 OR4N4 OR4N4C	9.04e-04	217	40	3	chr15q11
GeneFamily	Olfactory receptors, family 4	OR4M1 OR4D1 OR4M2 OR4K5 OR4N2 OR4K2 OR4N5 OR4D5 OR4N4 OR4D9	2.82e-15	129	28	10	151
GeneFamily	Olfactory receptors, family 2	OR2Y1 OR2T6	1.32e-02	113	28	2	149
Coexpression	ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_DN	OR4M1 OR4M2 OR4K5 OR4N2 OR4K2	1.46e-05	222	37	5	M16955
Disease	pancreatitis (biomarker_via_orthology)	SMO TLR3	7.23e-04	39	30	2	DOID:4989 (biomarker_via_orthology)
Disease	S-warfarin measurement	OR4D1 ABCC11	4.38e-03	97	30	2	EFO_0803323

Protein segments in the cluster

Peptide	Gene	Start	Entry
CFSFGIFVNGHFLQG	TMEM62	511	Q0P6H9
FAFFGGVHLLSLCSG	CPQ	6	Q9Y646
GCITQLFFLHFLGGG	OR4N4C	96	A0A096LPK9
TCEFLGGRFAVFFGL	FAM177B	81	A6PVY3
LFGCAGTILFFNLFL	KCNK12	151	Q9HB15
GLFTHNKCSGFFFGV	OR2T6	16	Q8NHC8
AFGTCGSHLLVVFLF	OR2Y1	236	Q8NGV0
GCLTQIFFLHLFTGT	OR4K2	96	Q8NGD2
GCIAQIFFIHLFTGG	OR4K5	96	Q8NGD3
IISFGGCIAQLFFLH	OR4M1	91	Q8NGD0
GCIAQLFFLHFVGAS	OR4M1	96	Q8NGD0
GCIAQLFFLHFAGAS	OR4M2	96	Q8NGB6
GCITQLFFLHFLGGG	OR4N2	96	Q8NGD1
GCITQLFFLHFLGGG	OR4N4	96	Q8N0Y3
SCITQLFFLHFLGAG	OR4N5	96	Q8IXE1
LGNVVHGVGLCFALF	ABCC11	196	Q96J66
LGGLVTVLCFFFNHG	DPY19L1	186	Q2PZI1
QLGGLITVLCFFFNH	DPY19L2	271	Q6NUT2
FCRLFFLSGGDVPFH	PAQR9	101	Q6ZVX9
GCVTQMFFFHLLGGA	OR4D9	96	Q8NGE8
ILGLNFCTFHGRGFT	DGAT2L6	256	Q6ZPD8
LTGSEHGFCFALFFF	FTCDNL1	131	E5RQL4
LIGGIHGFFLIEKCF	SLC39A12	451	Q504Y0
GLFHLGEFVNVFCHG	DDB1	996	Q16531
ELGGLITVLCFFFNH	DPY19L2P2	81	Q6ZN68
IFFFHLLGGGTVFFL	OR4D1	101	Q15615
TISFGGCLTQLFFFH	OR4D5	91	Q8NGN0
GCLTQLFFFHFIGGI	OR4D5	96	Q8NGN0
IGFLGHSISIFFIFQ	OR11H7	151	Q8NGC8
GGCVIQLFSFHFLGC	OR10G6	116	Q8NH81
GWVFGGGLCHLVFFL	PRLHR	126	P49683
RGLTFLLPFLFCGHF	TMEM120B	266	A0PK00
TSAGHPFLVNLFGCF	PKN1	671	Q16512
FFLCLGLALGAVFSF	SLC29A1	436	Q99808
CFHAIGRLFGLFLNN	TLR3	216	O15455
KICFFAFGAGHFLGN	TRABD2B	321	A6NFA1
LGFGFLCHSQFLRSQ	TMEM88	61	Q6PEY1
GFLAFGFVLITFSCH	SMO	456	Q99835
FNFFIFLGGACLLAI	TSPAN18	16	Q96SJ8
CLFQEGGFGRITFIH	ZNF502	76	Q8TBZ5
FDLAGITCGHFLVPF	VMP1	271	Q96GC9
LVFAFAHFDGILGLG	NAPSA	176	O96009