Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncalcium ion binding

CAPN12 VLDLR SPOCK1 GNPTAB CAPN3 GAS6 NOTCH2NLA ACTN1 PKD1L2 DLL1 NOTCH2NLC LRP1B SYT10 LDLR CRB1 NELL1 NOTCH2NLB JAG1 LRP1 LRP2 UMOD NOTCH1 NOTCH2

1.03e-1174910823GO:0005509
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor activity

VLDLR LRP1B LDLR LRP1 LRP2 SORL1

1.67e-10161086GO:0005041
GeneOntologyMolecularFunctioncargo receptor activity

VLDLR SCARF2 FOLR1 LRP1B LDLR SCARF1 LRP1 LRP2 SORL1

8.26e-10851089GO:0038024
GeneOntologyMolecularFunctionlipoprotein particle receptor activity

VLDLR LRP1B LDLR LRP1 LRP2 SORL1

1.11e-09211086GO:0030228
GeneOntologyMolecularFunctionNotch binding

NOTCH2NLA DLL1 NOTCH2NLB JAG1 NOTCH1

3.10e-07271085GO:0005112
GeneOntologyMolecularFunctionvirus receptor activity

NPC1 CD55 LDLR ITGB7 CD209 EGFR

6.73e-06851086GO:0001618
GeneOntologyMolecularFunctionexogenous protein binding

NPC1 CD55 LDLR ITGB7 CD209 EGFR

7.20e-06861086GO:0140272
GeneOntologyMolecularFunctionlipoprotein particle binding

VLDLR LDLR SCARF1 SORL1

3.72e-05351084GO:0071813
GeneOntologyMolecularFunctionprotein-lipid complex binding

VLDLR LDLR SCARF1 SORL1

3.72e-05351084GO:0071814
GeneOntologyMolecularFunctionintegrin binding

FN1 ADAM23 ACTN1 ADAM11 ITGB7 PTN EGFR

4.67e-051751087GO:0005178
GeneOntologyMolecularFunctionlow-density lipoprotein particle binding

LDLR SCARF1 SORL1

1.18e-04181083GO:0030169
GeneOntologyMolecularFunctionproteoglycan binding

FN1 PTN LRP1 FST

1.66e-04511084GO:0043394
GeneOntologyMolecularFunctionvery-low-density lipoprotein particle receptor activity

VLDLR LDLR

1.73e-0441082GO:0030229
GeneOntologyMolecularFunctionscavenger receptor activity

SCARF2 SCARF1 LRP1

4.09e-04271083GO:0005044
GeneOntologyMolecularFunctionenzyme regulator activity

RANBP2 FN1 PPP2R2D SPOCK1 CAPN3 GAS6 NAIP CD55 NCF2 PTN PPP2R2B PPP2R2C EGFR NOTCH1 TBCD SORL1 SOS1 SOS2

5.75e-04141810818GO:0030234
GeneOntologyMolecularFunctionclathrin heavy chain binding

LDLR LRP1

1.85e-03121082GO:0032050
GeneOntologyMolecularFunctionsuperoxide-generating NAD(P)H oxidase activity

CYBB NCF2

1.85e-03121082GO:0016175
GeneOntologyMolecularFunctionprotein phosphatase regulator activity

PPP2R2D PTN PPP2R2B PPP2R2C

2.13e-031001084GO:0019888
GeneOntologyMolecularFunctionamyloid-beta binding

LDLRAD3 LDLR LRP1 SORL1

2.29e-031021084GO:0001540
GeneOntologyMolecularFunctionsodium ion binding

CAPN3 SCN9A

2.53e-03141082GO:0031402
GeneOntologyBiologicalProcesspositive regulation of Notch signaling pathway

NOTCH2NLA DLL1 NOTCH2NLC NOTCH2NLB JAG1 NOTCH1

3.37e-07531086GO:0045747
GeneOntologyBiologicalProcesspositive regulation of lysosomal protein catabolic process

LDLR LRP1 LRP2

1.39e-0651083GO:1905167
GeneOntologyBiologicalProcessreceptor-mediated endocytosis

VLDLR SFTPD FOLR1 LDLRAD3 DLL1 LRP1B LDLR SCARF1 LRP1 LRP2 SORL1

1.58e-0633710811GO:0006898
GeneOntologyBiologicalProcesscell-substrate adhesion

FN1 SPOCK1 GAS6 ACTN1 ITGB7 PTN LIMS1 JAG1 LRP1 FGG NOTCH1 TBCD

1.62e-0641010812GO:0031589
GeneOntologyBiologicalProcessregulation of Notch signaling pathway

NOTCH2NLA DLL1 NOTCH2NLC NOTCH2NLB CBFA2T2 JAG1 NOTCH1

2.30e-061141087GO:0008593
GeneOntologyBiologicalProcessinhibition of neuroepithelial cell differentiation

DLL1 JAG1 NOTCH1

2.76e-0661083GO:0002085
GeneOntologyBiologicalProcessgliogenesis

FN1 LAMA2 DLL1 LDLR CRB1 PTN EGFR LRP1 LRP2 NOTCH1 NOTCH2 SOS1

2.99e-0643510812GO:0042063
GeneOntologyBiologicalProcesssymbiont entry into host cell

NPC1 GAS6 NAIP CD55 LDLR ITGB7 CD209 EGFR

3.02e-061691088GO:0046718
GeneOntologyBiologicalProcesssymbiont entry into host

NPC1 GAS6 NAIP CD55 LDLR ITGB7 CD209 EGFR

4.08e-061761088GO:0044409
GeneOntologyBiologicalProcesspositive regulation of protein catabolic process in the vacuole

LDLR LRP1 LRP2

4.81e-0671083GO:1904352
GeneOntologyBiologicalProcessregulation of BMP signaling pathway

TRIM33 UBE2O LRP2 FST NOTCH1 NOTCH2 SORL1

5.81e-061311087GO:0030510
GeneOntologyBiologicalProcessendocytosis

NPC1 VLDLR SFTPD FOLR1 GAS6 MYO18A NCF2 LDLRAD3 DLL1 LRP1B LDLR CD209 SCARF1 LRP1 LRP2 SORL1

6.24e-0682710816GO:0006897
GeneOntologyBiologicalProcessregeneration

FOLR1 CAPN3 GAS6 SCARF1 PTN EGFR LRP1 NOTCH1 ERVFRD-1

7.18e-062521089GO:0031099
GeneOntologyBiologicalProcessglial cell differentiation

LAMA2 DLL1 LDLR CRB1 PTN EGFR LRP1 NOTCH1 NOTCH2 SOS1

7.29e-0632110810GO:0010001
GeneOntologyBiologicalProcessregulation of cell-substrate adhesion

FN1 SPOCK1 PTN LIMS1 JAG1 LRP1 FGG NOTCH1 TBCD

7.65e-062541089GO:0010810
GeneOntologyBiologicalProcessregulation of pro-B cell differentiation

NOTCH1 SOS1 SOS2

7.67e-0681083GO:2000973
GeneOntologyBiologicalProcessartery morphogenesis

FOLR1 LDLR JAG1 LRP1 LRP2 NOTCH1

8.87e-06921086GO:0048844
GeneOntologyBiologicalProcessNotch signaling pathway

NOTCH2NLA DLL1 NOTCH2NLC NOTCH2NLB CBFA2T2 JAG1 NOTCH1 NOTCH2

1.49e-052101088GO:0007219
GeneOntologyBiologicalProcessloop of Henle development

DLL1 JAG1 UMOD

1.63e-05101083GO:0072070
GeneOntologyBiologicalProcessdistal tubule development

JAG1 UMOD NOTCH1

1.63e-05101083GO:0072017
GeneOntologyBiologicalProcessaxon guidance

LAMA2 LRTM2 MEGF9 SEMA3B LRP1 LRP2 NOTCH1 NOTCH2 SOS1

1.92e-052851089GO:0007411
GeneOntologyBiologicalProcessneuron projection guidance

LAMA2 LRTM2 MEGF9 SEMA3B LRP1 LRP2 NOTCH1 NOTCH2 SOS1

1.97e-052861089GO:0097485
GeneOntologyBiologicalProcessheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

SCARF2 CD209 CRB1 SCARF1 UMOD

1.98e-05631085GO:0007157
GeneOntologyBiologicalProcessneuron development

ACSL6 VLDLR FN1 SPOCK1 FOLR1 LAMA2 LRTM2 GBA2 CRB1 SCARF1 PTN MEGF9 EGFR CBFA2T2 SEMA3B LRP1 LRP2 NOTCH1 NOTCH2 TBCD SOS1

2.01e-05146310821GO:0048666
GeneOntologyBiologicalProcessbiological process involved in interaction with host

NPC1 GAS6 NAIP CD55 LDLR ITGB7 CD209 EGFR

2.69e-052281088GO:0051701
GeneOntologyBiologicalProcessregulation of lysosomal protein catabolic process

LDLR LRP1 LRP2

2.97e-05121083GO:1905165
GeneOntologyBiologicalProcessregulation of lymphoid progenitor cell differentiation

NOTCH1 SOS1 SOS2

2.97e-05121083GO:1905456
GeneOntologyBiologicalProcessaxon development

FN1 FOLR1 LAMA2 LRTM2 SCARF1 PTN MEGF9 SEMA3B LRP1 LRP2 NOTCH1 NOTCH2 SOS1

3.12e-0564210813GO:0061564
GeneOntologyBiologicalProcesscamera-type eye morphogenesis

DLL1 CRB1 PTN JAG1 MEGF11 NOTCH1 NOTCH2

3.29e-051711087GO:0048593
GeneOntologyBiologicalProcesspro-B cell differentiation

NOTCH1 SOS1 SOS2

3.84e-05131083GO:0002328
GeneOntologyBiologicalProcessimport into cell

NPC1 ACSL6 VLDLR SFTPD FOLR1 GAS6 MYO18A NCF2 LDLRAD3 DLL1 LRP1B LDLR CD209 SCARF1 LRP1 LRP2 SORL1

4.17e-05107410817GO:0098657
GeneOntologyBiologicalProcessnegative regulation of cell-substrate adhesion

SPOCK1 JAG1 LRP1 NOTCH1 TBCD

4.33e-05741085GO:0010812
GeneOntologyBiologicalProcessintegrin-mediated signaling pathway

FN1 LAMA2 ADAM11 ITGB7 PTN LIMS1

4.85e-051241086GO:0007229
GeneOntologyBiologicalProcessregulation of protein catabolic process in the vacuole

LDLR LRP1 LRP2

4.87e-05141083GO:1904350
GeneOntologyBiologicalProcessleft/right axis specification

DLL1 NOTCH1 NOTCH2

4.87e-05141083GO:0070986
GeneOntologyBiologicalProcessregulation of timing of cell differentiation

DLL1 JAG1 NOTCH1

6.07e-05151083GO:0048505
GeneOntologyBiologicalProcessregulation of cellular response to growth factor stimulus

FOLR1 DLL1 TRIM33 UBE2O LRP1 LRP2 FST NOTCH1 NOTCH2 SORL1

6.15e-0541210810GO:0090287
GeneOntologyBiologicalProcessartery development

FOLR1 LDLR JAG1 LRP1 LRP2 NOTCH1

7.17e-051331086GO:0060840
GeneOntologyBiologicalProcessrespiratory burst

CYBB CD55 NCF2 SLC37A4

7.50e-05431084GO:0045730
GeneOntologyBiologicalProcessviral life cycle

NPC1 GAS6 NAIP CD55 LDLR ITGB7 CD209 EGFR NOTCH1

7.55e-053401089GO:0019058
GeneOntologyBiologicalProcessBMP signaling pathway

TRIM33 UBE2O LRP2 FST NOTCH1 NOTCH2 SORL1

8.05e-051971087GO:0030509
GeneOntologyBiologicalProcesscellular response to tumor cell

NOTCH1 NOTCH2

8.12e-0531082GO:0071228
GeneOntologyBiologicalProcessregulation of transmembrane receptor protein serine/threonine kinase signaling pathway

FOLR1 TRIM33 UBE2O LRP1 LRP2 FST NOTCH1 NOTCH2 SORL1

8.82e-053471089GO:0090092
GeneOntologyBiologicalProcessnegative regulation of epithelial cell apoptotic process

NPC1 GAS6 NAIP LIMS1 FGG

8.92e-05861085GO:1904036
GeneOntologyBiologicalProcessregulation of development, heterochronic

DLL1 JAG1 NOTCH1

9.00e-05171083GO:0040034
GeneOntologyBiologicalProcesspositive regulation of axon regeneration

SCARF1 PTN LRP1

9.00e-05171083GO:0048680
GeneOntologyBiologicalProcessbiological process involved in symbiotic interaction

NPC1 FN1 GAS6 NAIP CD55 LDLR ITGB7 CD209 EGFR

9.62e-053511089GO:0044403
GeneOntologyBiologicalProcessregulation of cell adhesion

FN1 SPOCK1 SFTPD LAMA2 CD55 DLL1 CD209 PTN LIMS1 JAG1 LRP1 ZFHX3 FGG NOTCH1 TBCD

9.69e-0592710815GO:0030155
GeneOntologyBiologicalProcesseye morphogenesis

DLL1 CRB1 PTN JAG1 MEGF11 NOTCH1 NOTCH2

1.00e-042041087GO:0048592
GeneOntologyBiologicalProcessastrocyte development

DLL1 LDLR EGFR LRP1

1.07e-04471084GO:0014002
GeneOntologyBiologicalProcesspositive regulation of neuron projection regeneration

SCARF1 PTN LRP1

1.08e-04181083GO:0070572
GeneOntologyBiologicalProcessretina morphogenesis in camera-type eye

DLL1 CRB1 PTN MEGF11 NOTCH1

1.11e-04901085GO:0060042
GeneOntologyBiologicalProcessneuron projection development

ACSL6 VLDLR FN1 SPOCK1 FOLR1 LAMA2 LRTM2 SCARF1 PTN MEGF9 EGFR CBFA2T2 SEMA3B LRP1 LRP2 NOTCH1 NOTCH2 SOS1

1.17e-04128510818GO:0031175
GeneOntologyBiologicalProcesspositive regulation of endocytosis

SFTPD GAS6 MYO18A DLL1 CD209 LRP1 LRP2

1.31e-042131087GO:0045807
GeneOntologyBiologicalProcessresponse to BMP

TRIM33 UBE2O LRP2 FST NOTCH1 NOTCH2 SORL1

1.39e-042151087GO:0071772
GeneOntologyBiologicalProcesscellular response to BMP stimulus

TRIM33 UBE2O LRP2 FST NOTCH1 NOTCH2 SORL1

1.39e-042151087GO:0071773
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

VLDLR FN1 LAMA2 LRTM2 PTN MEGF9 SEMA3B LRP1 LRP2 NOTCH1 NOTCH2 TBCD SOS1

1.46e-0474810813GO:0048667
GeneOntologyBiologicalProcesspulmonary valve morphogenesis

JAG1 NOTCH1 NOTCH2

1.49e-04201083GO:0003184
GeneOntologyBiologicalProcesscell-cell adhesion

SFTPD SCARF2 CD55 FNDC3A ACTN1 ITGB7 CD209 CRB1 SCARF1 LIMS1 EGFR JAG1 UMOD FGG MEGF11 NOTCH1

1.50e-04107710816GO:0098609
GeneOntologyBiologicalProcesspositive regulation of phagocytosis

SFTPD GAS6 MYO18A CD209 LRP1

1.73e-04991085GO:0050766
GeneOntologyBiologicalProcessresponse to growth factor

FOLR1 GAS6 DLL1 TRIM33 UBE2O EGFR LRP1 LRP2 ZFHX3 FST NOTCH1 NOTCH2 SORL1 SOS1

2.08e-0488310814GO:0070848
GeneOntologyBiologicalProcesscholesterol metabolic process

NPC1 VLDLR GBA2 LDLR SCARF1 LRP1

2.19e-041631086GO:0008203
GeneOntologyBiologicalProcessastrocyte differentiation

DLL1 LDLR EGFR LRP1 NOTCH1

2.28e-041051085GO:0048708
GeneOntologyBiologicalProcessskin epidermis development

DLL1 NSUN2 EGFR FST NOTCH1 SOS1

2.41e-041661086GO:0098773
GeneOntologyBiologicalProcesspulmonary valve development

JAG1 NOTCH1 NOTCH2

2.61e-04241083GO:0003177
GeneOntologyBiologicalProcesslysosomal protein catabolic process

LDLR LRP1 LRP2

2.61e-04241083GO:1905146
GeneOntologyBiologicalProcessnegative regulation of inner ear receptor cell differentiation

DLL1 NOTCH1

2.69e-0451082GO:2000981
GeneOntologyBiologicalProcesschemoattraction of axon

LRP1 LRP2

2.69e-0451082GO:0061642
GeneOntologyBiologicalProcessbehavioral response to chemical pain

ADAM11 SCN9A

2.69e-0451082GO:0061366
GeneOntologyBiologicalProcessbehavioral response to formalin induced pain

ADAM11 SCN9A

2.69e-0451082GO:0061368
GeneOntologyBiologicalProcesscompartment pattern specification

DLL1 NOTCH1

2.69e-0451082GO:0007386
GeneOntologyBiologicalProcessnegative regulation of inner ear auditory receptor cell differentiation

DLL1 NOTCH1

2.69e-0451082GO:0045608
GeneOntologyBiologicalProcessnegative regulation of mechanoreceptor differentiation

DLL1 NOTCH1

2.69e-0451082GO:0045632
GeneOntologyBiologicalProcesspositive regulation of protein transport

GAS6 MYO18A ADCY8 EGFR LRP1 LRP2 FGG SORL1

2.76e-043191088GO:0051222
GeneOntologyBiologicalProcessnephron tubule development

DLL1 JAG1 UMOD NOTCH1 NOTCH2

2.84e-041101085GO:0072080
GeneOntologyBiologicalProcessneuron projection morphogenesis

VLDLR FN1 LAMA2 LRTM2 PTN MEGF9 EGFR SEMA3B LRP1 LRP2 NOTCH1 NOTCH2 SOS1

2.88e-0480210813GO:0048812
GeneOntologyBiologicalProcesspositive regulation of Ras protein signal transduction

NOTCH1 NOTCH2 SOS1

2.95e-04251083GO:0046579
GeneOntologyBiologicalProcesssecondary alcohol metabolic process

NPC1 VLDLR GBA2 LDLR SCARF1 LRP1

3.30e-041761086GO:1902652
GeneOntologyBiologicalProcesslymphoid progenitor cell differentiation

NOTCH1 SOS1 SOS2

3.32e-04261083GO:0002320
GeneOntologyBiologicalProcesssterol metabolic process

NPC1 VLDLR GBA2 LDLR SCARF1 LRP1

3.41e-041771086GO:0016125
GeneOntologyBiologicalProcessinflammatory response

CYBB USP18 FN1 NAIP LDLR ADCY8 PTN NLRP10 EGFR NFKBIB SCN9A LRP1 UMOD NOTCH1 NOTCH2

3.48e-04104310815GO:0006954
GeneOntologyBiologicalProcessblood vessel development

CYBB GGNBP2 FN1 FOLR1 DLL1 LDLR PTN JAG1 LRP1 LRP2 NOTCH1 NOTCH2 ERVFRD-1 SOS1

3.49e-0492910814GO:0001568
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

VLDLR FN1 LAMA2 LRTM2 PTN MEGF9 EGFR SEMA3B LRP1 LRP2 NOTCH1 NOTCH2 SOS1

3.52e-0481910813GO:0120039
GeneOntologyBiologicalProcessrenal tubule development

DLL1 JAG1 UMOD NOTCH1 NOTCH2

3.63e-041161085GO:0061326
GeneOntologyBiologicalProcessregulation of neurogenesis

FN1 DLL1 LDLR PTN EGFR LRP1 LRP2 NOTCH1 NOTCH2 SORL1

3.75e-0451510810GO:0050767
GeneOntologyBiologicalProcesscell projection morphogenesis

VLDLR FN1 LAMA2 LRTM2 PTN MEGF9 EGFR SEMA3B LRP1 LRP2 NOTCH1 NOTCH2 SOS1

3.81e-0482610813GO:0048858
GeneOntologyBiologicalProcesschemotaxis

FN1 SFTPD GAS6 LRTM2 PTN SEMA3B LRP1 LRP2 SLC37A4 NOTCH1

3.87e-0451710810GO:0006935
GeneOntologyBiologicalProcesstaxis

FN1 SFTPD GAS6 LRTM2 PTN SEMA3B LRP1 LRP2 SLC37A4 NOTCH1

3.99e-0451910810GO:0042330
GeneOntologyBiologicalProcessinner ear receptor cell fate commitment

DLL1 NOTCH1

4.02e-0461082GO:0060120
GeneOntologyBiologicalProcessciliary body morphogenesis

JAG1 NOTCH2

4.02e-0461082GO:0061073
GeneOntologyBiologicalProcesspulmonary artery morphogenesis

JAG1 LRP2

4.02e-0461082GO:0061156
GeneOntologyBiologicalProcessauditory receptor cell fate commitment

DLL1 NOTCH1

4.02e-0461082GO:0009912
GeneOntologyBiologicalProcessarterial endothelial cell differentiation

DLL1 NOTCH1

4.02e-0461082GO:0060842
GeneOntologyBiologicalProcesscamera-type eye development

DLL1 CRB1 PTN EGFR JAG1 MEGF11 NOTCH1 NOTCH2 SOS1

4.05e-044261089GO:0043010
GeneOntologyBiologicalProcessprotein catabolic process in the vacuole

LDLR LRP1 LRP2

4.16e-04281083GO:0007039
GeneOntologyBiologicalProcessregulation of nervous system development

FN1 LRTM2 DLL1 LDLR PTN EGFR LRP1 LRP2 NOTCH1 NOTCH2 SORL1

4.37e-0462510811GO:0051960
GeneOntologyBiologicalProcessembryo development

MBTD1 GGNBP2 FN1 FOLR1 LAMA2 DLL1 NSUN2 LRP1B XAB2 LIMS1 EGFR JAG1 LRP2 POFUT2 NOTCH1 NOTCH2 ERVFRD-1 SOS1

4.59e-04143710818GO:0009790
GeneOntologyBiologicalProcesstissue remodeling

CRB1 PTN EGFR JAG1 LRP1 UMOD NOTCH2

4.61e-042621087GO:0048771
GeneOntologyBiologicalProcessastrocyte activation

LDLR EGFR LRP1

4.62e-04291083GO:0048143
GeneOntologyBiologicalProcessaxon regeneration

FOLR1 SCARF1 PTN LRP1

4.73e-04691084GO:0031103
GeneOntologyCellularComponentapical part of cell

VLDLR FN1 FOLR1 CD55 DLL1 LDLR ADCY8 CRB1 EGFR JAG1 LRP1 LRP2 UMOD NOTCH1

3.43e-0659211214GO:0045177
GeneOntologyCellularComponentbasolateral plasma membrane

FOLR1 NAIP LDLR ADCY8 SLCO4C1 EGFR LRP1 UMOD MEGF11

5.70e-053201129GO:0016323
GeneOntologyCellularComponentapical plasma membrane

FN1 FOLR1 CD55 DLL1 ADCY8 CRB1 EGFR JAG1 LRP2 UMOD NOTCH1

6.19e-0548711211GO:0016324
GeneOntologyCellularComponentclathrin-coated pit

VLDLR LDLR ADCY8 LRP1 LRP2

7.05e-05801125GO:0005905
GeneOntologyCellularComponentcell surface

VLDLR FOLR1 MYO18A CD55 LDLR ITGB7 CD209 PTN EGFR CD163L1 LRP1 LRP2 UMOD FGG NOTCH1 NOTCH2 SORL1

8.60e-05111111217GO:0009986
GeneOntologyCellularComponentprotein phosphatase type 2A complex

PPP2R2D PPP2R2B PPP2R2C

1.15e-04181123GO:0000159
GeneOntologyCellularComponentbasal plasma membrane

FOLR1 NAIP LDLR ADCY8 SLCO4C1 EGFR LRP1 UMOD MEGF11

1.23e-043541129GO:0009925
GeneOntologyCellularComponentbasal part of cell

FOLR1 NAIP LDLR ADCY8 SLCO4C1 EGFR LRP1 UMOD MEGF11

2.01e-043781129GO:0045178
GeneOntologyCellularComponentendocytic vesicle

CYBB SFTPD MYO18A NCF2 LDLR SCARF1 EGFR LRP1 LRP2

2.26e-043841129GO:0030139
GeneOntologyCellularComponentclathrin-coated vesicle

SFTPD FOLR1 LDLR ADCY8 EGFR LRP1 LRP2

2.91e-042371127GO:0030136
GeneOntologyCellularComponentplatelet alpha granule lumen

FN1 GAS6 ACTN1 FGG

4.62e-04671124GO:0031093
GeneOntologyCellularComponentvesicle membrane

NPC1 CYBB SPIRE2 FOLR1 CD55 FNDC3A ACTN1 SYT10 LDLR ADCY8 SCARF1 SLCO4C1 EGFR LRP1 LRP2 NOTCH1 SORL1

6.77e-04132511217GO:0012506
GeneOntologyCellularComponentfibrinogen complex

FN1 FGG

7.80e-0481122GO:0005577
GeneOntologyCellularComponentendocytic vesicle membrane

CYBB LDLR SCARF1 EGFR LRP1 LRP2

9.94e-042121126GO:0030666
GeneOntologyCellularComponentcluster of actin-based cell projections

FOLR1 MYO18A ACTN1 PKHD1L1 LOXHD1 LRP2

1.29e-032231126GO:0098862
GeneOntologyCellularComponentplatelet alpha granule

FN1 GAS6 ACTN1 FGG

1.58e-03931124GO:0031091
GeneOntologyCellularComponentcytoplasmic vesicle membrane

NPC1 CYBB SPIRE2 FOLR1 CD55 ACTN1 SYT10 LDLR ADCY8 SCARF1 SLCO4C1 EGFR LRP1 LRP2 NOTCH1 SORL1

1.61e-03130711216GO:0030659
GeneOntologyCellularComponentclathrin-coated endocytic vesicle

SFTPD LDLR EGFR LRP2

2.14e-031011124GO:0045334
GeneOntologyCellularComponentsecretory granule

CYBB FN1 GAS6 CD55 FNDC3A NCF2 ACTN1 SPATA1 SLCO4C1 LRP1 ZPBP2 FGG NOTCH1

3.03e-03101411213GO:0030141
GeneOntologyCellularComponentphosphatase complex

PPP2R2D PPP2R2B PPP2R2C

3.21e-03551123GO:1903293
GeneOntologyCellularComponentprotein serine/threonine phosphatase complex

PPP2R2D PPP2R2B PPP2R2C

3.21e-03551123GO:0008287
GeneOntologyCellularComponentcoated vesicle

SFTPD FOLR1 LDLR ADCY8 EGFR LRP1 LRP2

3.28e-033601127GO:0030135
HumanPhenoAbnormal phagocytosis

CYBB NCF2 SLC37A4

4.44e-065403HP:0010977
HumanPhenoAbsence of bactericidal oxidative respiratory burst in phagocytes

CYBB NCF2 SLC37A4

4.44e-065403HP:0002723
MousePhenoabnormal somatic sensory system morphology

NPC1 VLDLR FOLR1 GNPTAB LAMA2 DLL1 NSUN2 LDLR CRB1 LOXHD1 EGFR JAG1 FST MEGF11 NOTCH1

2.19e-057028615MP:0000959
MousePhenodecreased circulating transferrin level

LRP1B LDLR UMOD

2.62e-0510863MP:0011894
DomainEGF-like_CS

VLDLR FN1 ADAM23 SCARF2 GAS6 NOTCH2NLA LAMA2 ADAM11 DLL1 NOTCH2NLC LRP1B LDLR ITGB7 CRB1 SCARF1 NELL1 MEGF9 JAG1 LRP1 LRP2 UMOD MEGF11 NOTCH1 NOTCH2 SORL1

2.18e-2326111125IPR013032
DomainEGF

VLDLR BRINP3 ADAM23 SCARF2 GAS6 NOTCH2NLA LAMA2 ADAM11 DLL1 NOTCH2NLC LRP1B LDLR CRB1 SCARF1 NELL1 MEGF9 JAG1 LRP1 LRP2 UMOD MEGF11 NOTCH1 NOTCH2 SORL1

3.88e-2323511124SM00181
DomainEGF_1

VLDLR FN1 ADAM23 SCARF2 GAS6 NOTCH2NLA LAMA2 ADAM11 DLL1 NOTCH2NLC LRP1B LDLR ITGB7 CRB1 SCARF1 NELL1 MEGF9 JAG1 LRP1 LRP2 UMOD MEGF11 NOTCH1 NOTCH2

2.78e-2225511124PS00022
DomainEGF_2

VLDLR ADAM23 SCARF2 GAS6 NOTCH2NLA LAMA2 ADAM11 DLL1 NOTCH2NLC LRP1B LDLR ITGB7 CRB1 SCARF1 NELL1 MEGF9 JAG1 LRP1 LRP2 UMOD MEGF11 NOTCH1 NOTCH2 SORL1

6.98e-2226511124PS01186
DomainEGF-like_dom

VLDLR ADAM23 SCARF2 GAS6 NOTCH2NLA LAMA2 ADAM11 DLL1 NOTCH2NLC LRP1B LDLR CRB1 SCARF1 NELL1 MEGF9 JAG1 LRP1 LRP2 UMOD MEGF11 NOTCH1 NOTCH2 SORL1

3.48e-2124911123IPR000742
DomainEGF_3

VLDLR ADAM23 SCARF2 GAS6 NOTCH2NLA ADAM11 DLL1 NOTCH2NLC LRP1B LDLR CRB1 SCARF1 NELL1 JAG1 LRP1 LRP2 UMOD MEGF11 NOTCH1 NOTCH2 SORL1

4.32e-1923511121PS50026
DomainEGF_Ca-bd_CS

VLDLR GAS6 NOTCH2NLA DLL1 NOTCH2NLC LRP1B LDLR CRB1 NELL1 JAG1 LRP1 LRP2 UMOD NOTCH1 NOTCH2

1.58e-179711115IPR018097
DomainEGF_CA

VLDLR GAS6 NOTCH2NLA DLL1 NOTCH2NLC LRP1B LDLR CRB1 NELL1 JAG1 LRP1 LRP2 UMOD NOTCH1 NOTCH2

2.18e-179911115PS01187
DomainASX_HYDROXYL

VLDLR GAS6 NOTCH2NLA DLL1 NOTCH2NLC LRP1B LDLR CRB1 NELL1 JAG1 LRP1 LRP2 UMOD NOTCH1 NOTCH2

2.56e-1710011115PS00010
DomainGrowth_fac_rcpt_

VLDLR BRINP3 SCARF2 GAS6 DLL1 LRP1B LDLR CRB1 SCARF1 NELL1 EGFR JAG1 LRP1 LRP2 UMOD NOTCH1 NOTCH2

4.48e-1715611117IPR009030
DomainEGF-type_Asp/Asn_hydroxyl_site

VLDLR GAS6 NOTCH2NLA DLL1 NOTCH2NLC LRP1B LDLR CRB1 NELL1 JAG1 LRP1 LRP2 UMOD NOTCH1 NOTCH2

6.36e-1710611115IPR000152
DomainEGF_CA

VLDLR GAS6 NOTCH2NLA DLL1 NOTCH2NLC LRP1B LDLR CRB1 NELL1 JAG1 LRP1 LRP2 UMOD NOTCH1 NOTCH2

5.59e-1612211115SM00179
DomainEGF-like_Ca-bd_dom

VLDLR GAS6 NOTCH2NLA DLL1 NOTCH2NLC LRP1B LDLR CRB1 NELL1 JAG1 LRP1 LRP2 UMOD NOTCH1 NOTCH2

7.17e-1612411115IPR001881
DomainEGF_CA

VLDLR GAS6 NOTCH2NLA NOTCH2NLC LRP1B LDLR NELL1 JAG1 LRP1 LRP2 UMOD NOTCH1 NOTCH2

3.40e-158611113PF07645
DomainEGF_extracell

ADAM23 SCARF2 ADAM11 LRP1B ITGB7 SCARF1 NELL1 JAG1 LRP2 MEGF11 NOTCH1

5.29e-146011111IPR013111
DomainEGF_2

ADAM23 SCARF2 ADAM11 LRP1B ITGB7 SCARF1 NELL1 JAG1 LRP2 MEGF11 NOTCH1

5.29e-146011111PF07974
DomainEGF

VLDLR GAS6 NOTCH2NLA DLL1 NOTCH2NLC LRP1B CRB1 JAG1 LRP1 LRP2 UMOD NOTCH1 NOTCH2

5.48e-1312611113PF00008
DomainLdl_recept_b

VLDLR LRP1B LDLR LRP1 LRP2 SORL1

1.11e-10141116PF00058
DomainLDLRB

VLDLR LRP1B LDLR LRP1 LRP2 SORL1

1.11e-10141116PS51120
DomainLY

VLDLR LRP1B LDLR LRP1 LRP2 SORL1

1.84e-10151116SM00135
DomainLDLR_classB_rpt

VLDLR LRP1B LDLR LRP1 LRP2 SORL1

1.84e-10151116IPR000033
DomainhEGF

GAS6 DLL1 CRB1 JAG1 MEGF11 NOTCH1 NOTCH2

2.31e-10281117PF12661
DomainLDLR_class-A_CS

VLDLR LDLRAD3 LRP1B LDLR LRP1 LRP2 SORL1

3.43e-09401117IPR023415
DomainLdl_recept_a

VLDLR LDLRAD3 LRP1B LDLR LRP1 LRP2 SORL1

8.15e-09451117PF00057
Domain-

VLDLR LDLRAD3 LRP1B LDLR LRP1 LRP2 SORL1

9.56e-094611174.10.400.10
DomainLDLRA_1

VLDLR LDLRAD3 LRP1B LDLR LRP1 LRP2 SORL1

1.30e-08481117PS01209
DomainLDrepeatLR_classA_rpt

VLDLR LDLRAD3 LRP1B LDLR LRP1 LRP2 SORL1

1.51e-08491117IPR002172
DomainLDLa

VLDLR LDLRAD3 LRP1B LDLR LRP1 LRP2 SORL1

1.51e-08491117SM00192
DomainLDLRA_2

VLDLR LDLRAD3 LRP1B LDLR LRP1 LRP2 SORL1

1.51e-08491117PS50068
DomainNotch_dom

GNPTAB PAPPA NOTCH1 NOTCH2

4.08e-0871114IPR000800
DomainNotch

GNPTAB PAPPA NOTCH1 NOTCH2

4.08e-0871114PF00066
DomainNL

GNPTAB PAPPA NOTCH1 NOTCH2

4.08e-0871114SM00004
Domain-

VLDLR LRP1B LDLR LRP1 LRP2 SORL1

1.07e-073911162.120.10.30
Domain6-blade_b-propeller_TolB-like

VLDLR LRP1B LDLR LRP1 LRP2 SORL1

2.97e-07461116IPR011042
DomainPP2A_PR55_CS

PPP2R2D PPP2R2B PPP2R2C

8.14e-0741113IPR018067
DomainPP2A_PR55

PPP2R2D PPP2R2B PPP2R2C

8.14e-0741113IPR000009
DomainPR55_2

PPP2R2D PPP2R2B PPP2R2C

8.14e-0741113PS01025
DomainPR55_1

PPP2R2D PPP2R2B PPP2R2C

8.14e-0741113PS01024
DomainLaminin_EGF

SCARF2 LAMA2 SCARF1 MEGF9 MEGF11

1.91e-06351115PF00053
DomainLNR

GNPTAB NOTCH1 NOTCH2

2.03e-0651113PS50258
DomainLaminin_EGF

SCARF2 LAMA2 SCARF1 MEGF9 MEGF11

2.91e-06381115IPR002049
DomaincEGF

GAS6 LRP1B LRP1 LRP2

1.60e-05261114PF12662
DomaincEGF

GAS6 LRP1B LRP1 LRP2

1.60e-05261114IPR026823
DomainDUF5050

LRP1B LRP1

3.50e-0521112IPR032485
DomainDUF5050

LRP1B LRP1

3.50e-0521112PF16472
DomainEGF_Lam

SCARF2 LAMA2 MEGF9 MEGF11

5.37e-05351114SM00180
DomainLaminin_G_2

GAS6 LAMA2 CRB1 NELL1

9.16e-05401114PF02210
DomainDUF3454

NOTCH1 NOTCH2

1.05e-0431112PF11936
DomainDUF3454_notch

NOTCH1 NOTCH2

1.05e-0431112IPR024600
DomainDUF3454

NOTCH1 NOTCH2

1.05e-0431112SM01334
DomainLamG

GAS6 LAMA2 CRB1 NELL1

1.34e-04441114SM00282
DomainNotch

NOTCH1 NOTCH2

2.08e-0441112IPR008297
DomainNODP

NOTCH1 NOTCH2

2.08e-0441112PF07684
DomainNotch_NODP_dom

NOTCH1 NOTCH2

2.08e-0441112IPR011656
DomainDSL

DLL1 JAG1

2.08e-0441112PF01414
DomainNotch_NOD_dom

NOTCH1 NOTCH2

2.08e-0441112IPR010660
DomainNOD

NOTCH1 NOTCH2

2.08e-0441112PF06816
DomainDSL

DLL1 JAG1

2.08e-0441112SM00051
DomainNOD

NOTCH1 NOTCH2

2.08e-0441112SM01338
DomainNODP

NOTCH1 NOTCH2

2.08e-0441112SM01339
Domain-

GAS6 LAMA2 CRB1 NELL1 PAPPA

2.56e-049511152.60.120.200
DomainConA-like_dom

GAS6 LAMA2 TRIM43 CRB1 TRIM43B NELL1 PAPPA

3.35e-042191117IPR013320
DomainDSL

DLL1 JAG1

3.46e-0451112PS51051
DomainNotch_ligand_N

DLL1 JAG1

3.46e-0451112IPR011651
DomainMNNL

DLL1 JAG1

3.46e-0451112PF07657
DomainDSL

DLL1 JAG1

3.46e-0451112IPR001774
DomainLaminin_G

GAS6 LAMA2 CRB1 NELL1

3.92e-04581114IPR001791
DomainBBOX

TRIM43 TRIM24 TRIM43B TRIM33

7.59e-04691114SM00336
Domain-

TRIM43 TRIM24 TRIM43B TRIM33

8.45e-047111144.10.45.10
DomainPHD

KDM5C TRIM24 TRIM33 BAZ2A

1.04e-03751114PF00628
DomainZnf_PHD-finger

KDM5C TRIM24 TRIM33 BAZ2A

1.26e-03791114IPR019787
DomainKazal_2

SPOCK1 SLCO4C1 FST

1.26e-03361113PF07648
DomainZF_BBOX

TRIM43 TRIM24 TRIM43B TRIM33

1.32e-03801114PS50119
DomainBROMODOMAIN_1

TRIM24 TRIM33 BAZ2A

1.37e-03371113PS00633
DomainZnf_B-box

TRIM43 TRIM24 TRIM43B TRIM33

1.38e-03811114IPR000315
DomainBromodomain

TRIM24 TRIM33 BAZ2A

1.48e-03381113PF00439
DomainLAM_G_DOMAIN

GAS6 LAMA2 CRB1

1.48e-03381113PS50025
DomainBROMODOMAIN_2

TRIM24 TRIM33 BAZ2A

1.85e-03411113PS50014
DomainZnf_FYVE_PHD

SPIRE2 KDM5C TRIM24 TRIM33 BAZ2A

1.85e-031471115IPR011011
DomainLaminin_G_1

GAS6 LAMA2

1.86e-03111112PF00054
DomainPHD

KDM5C TRIM24 TRIM33 BAZ2A

1.96e-03891114SM00249
DomainBromodomain

TRIM24 TRIM33 BAZ2A

1.98e-03421113IPR001487
DomainBROMO

TRIM24 TRIM33 BAZ2A

1.98e-03421113SM00297
Domain-

TRIM24 TRIM33 BAZ2A

1.98e-034211131.20.920.10
DomainZnf_PHD

KDM5C TRIM24 TRIM33 BAZ2A

2.12e-03911114IPR001965
DomainEGF_dom

NELL1 UMOD

2.22e-03121112IPR024731
Domaincalpain_III

CAPN12 CAPN3

2.22e-03121112SM00720
DomainC2_III

CAPN12 CAPN3

2.22e-03121112IPR033883
DomainQuinoprot_gluc/sorb_DH

EML5 LRP1

2.22e-03121112IPR011041
DomainEGF_3

NELL1 UMOD

2.22e-03121112PF12947
DomainCalpain_III

CAPN12 CAPN3

2.22e-03121112IPR022683
DomainZF_PHD_2

KDM5C TRIM24 TRIM33 BAZ2A

2.48e-03951114PS50016
DomainZF_PHD_1

KDM5C TRIM24 TRIM33 BAZ2A

2.58e-03961114PS01359
DomainCalpain_III

CAPN12 CAPN3

2.62e-03131112PF01067
DomainCalpain_domain_III

CAPN12 CAPN3

2.62e-03131112IPR022682
DomainRas_G-nucl-exch_fac_CS

SOS1 SOS2

3.04e-03141112IPR019804
DomainCalpain_cysteine_protease

CAPN12 CAPN3

3.04e-03141112IPR022684
DomainKAZAL_2

SPOCK1 SLCO4C1 FST

3.27e-03501113PS51465
DomainKazal_dom

SPOCK1 SLCO4C1 FST

3.46e-03511113IPR002350
DomainBbox_C

TRIM24 TRIM33

3.49e-03151112IPR003649
PathwayKEGG_DORSO_VENTRAL_AXIS_FORMATION

SPIRE2 EGFR NOTCH1 NOTCH2 SOS1 SOS2

5.32e-0924866M11190
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_SIGNALING_PATHWAY

DLL1 JAG1 NOTCH1 NOTCH2

8.85e-0713864M47423
PathwayPID_UPA_UPAR_PATHWAY

VLDLR FN1 EGFR LRP1 FGG

5.35e-0642865M174
PathwayREACTOME_SIGNALING_BY_NOTCH1_T_7_9_NOTCH1_M1580_K2555_TRANSLOCATION_MUTANT

DLL1 JAG1 NOTCH1

7.54e-067863M27199
PathwayWP_FATTY_ACIDS_AND_LIPOPROTEINS_TRANSPORT_IN_HEPATOCYTES

NPC1 ACSL6 VLDLR SCARF2 LRP1B LDLR CD209 CD163L1 LRP1 LRP2 SORL1

1.93e-053818611M48063
PathwayWP_CANONICAL_AND_NONCANONICAL_NOTCH_SIGNALING

DLL1 JAG1 NOTCH1 NOTCH2

2.04e-0527864M39545
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_RALGDS_SIGNALING_PATHWAY

EGFR SOS1 SOS2

3.49e-0511863M47436
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_RASSF1_SIGNALING_PATHWAY

EGFR SOS1 SOS2

3.49e-0511863M47432
PathwayBIOCARTA_HES_PATHWAY

DLL1 NOTCH1 NOTCH2

4.63e-0512863MM1562
PathwayBIOCARTA_HES_PATHWAY

DLL1 NOTCH1 NOTCH2

4.63e-0512863M22042
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00380

JAG1 NOTCH1 NOTCH2

4.63e-0512863M47532
PathwayWP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER

FN1 DLL1 JAG1 NOTCH1 NOTCH2 SOS1 SOS2

5.61e-05161867M39770
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_JNK_SIGNALING_PATHWAY

EGFR SOS1 SOS2

6.00e-0513863M47594
PathwayWP_FAMILIAL_HYPERLIPIDEMIA_TYPE_3

VLDLR LDLR LRP1

6.00e-0513863M42551
PathwayREACTOME_SIGNALING_BY_NOTCH

DLL1 EGFR JAG1 NOTCH1

9.02e-0539864MM14604
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_PI3K_SIGNALING_PATHWAY

EGFR SOS1 SOS2

9.46e-0515863M47389
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_RAS_ERK_SIGNALING_PATHWAY

EGFR SOS1 SOS2

9.46e-0515863M47375
PathwayREACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS

FN1 FGG SOS1

9.46e-0515863M1262
PathwayREACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS

FN1 FGG SOS1

9.46e-0515863MM14959
PathwayKEGG_MEDICUS_REFERENCE_TGFA_EGFR_RAS_ERK_SIGNALING_PATHWAY

EGFR SOS1 SOS2

9.46e-0515863M47480
PathwayKEGG_MEDICUS_VARIANT_EGF_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

EGFR SOS1 SOS2

9.46e-0515863M47495
PathwayKEGG_MEDICUS_REFERENCE_EREG_EGFR_RAS_ERK_SIGNALING_PATHWAY

EGFR SOS1 SOS2

9.46e-0515863M47496
PathwayKEGG_MEDICUS_REFERENCE_AREG_EGFR_RAS_ERK_SIGNALING_PATHWAY

EGFR SOS1 SOS2

9.46e-0515863M47497
PathwayREACTOME_SIGNALING_BY_NOTCH1_HD_DOMAIN_MUTANTS_IN_CANCER

DLL1 JAG1 NOTCH1

9.46e-0515863M27202
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E5_TO_EGFR_RAS_ERK_SIGNALING_PATHWAY

EGFR SOS1 SOS2

9.46e-0515863M47531
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_ERK_SIGNALING_PATHWAY

EGFR SOS1 SOS2

1.16e-0416863M47363
PathwayKEGG_MEDICUS_REFERENCE_EGF_ERBB2_RAS_ERK_SIGNALING_PATHWAY

EGFR SOS1 SOS2

1.16e-0416863M47381
PathwayKEGG_MEDICUS_VARIANT_NOTCH_OVEREXPRESSION_TO_NOTCH_SIGNALING_PATHWAY

DLL1 JAG1 NOTCH1

1.16e-0416863M47424
PathwayWP_EBOLA_VIRUS_INFECTION_IN_HOST

NPC1 FOLR1 GAS6 ACTN1 CD209 EGFR

1.35e-04129866M39693
PathwayWP_NOTCH1_REGULATION_OF_ENDOTHELIAL_CELL_CALCIFICATION

DLL1 JAG1 NOTCH1

1.40e-0417863M39389
PathwayWP_DELTANOTCH_SIGNALING_PATHWAY

DLL1 EGFR JAG1 NOTCH1 NOTCH2

1.42e-0482865MM15922
PathwayWP_NOTCH_SIGNALING_WP268

DLL1 JAG1 NOTCH1 NOTCH2

1.59e-0445864M39571
PathwayWP_NOTCH_SIGNALING_PATHWAY

DLL1 JAG1 NOTCH1 NOTCH2

1.73e-0446864MM15971
PathwayKEGG_NOTCH_SIGNALING_PATHWAY

DLL1 JAG1 NOTCH1 NOTCH2

1.89e-0447864M7946
PathwayREACTOME_SIGNALING_BY_NOTCH3

DLL1 EGFR JAG1

1.98e-0419863MM15594
PathwayKEGG_MEDICUS_REFERENCE_PP2A_AKT_SIGNALING_PATHWAY

PPP2R2D PPP2R2B PPP2R2C

1.98e-0419863M47525
PathwayKEGG_FOCAL_ADHESION

FN1 LAMA2 ACTN1 ITGB7 EGFR SOS1 SOS2

2.11e-04199867M7253
PathwayWP_PI3KAKT_SIGNALING

FN1 PPP2R2D LAMA2 ITGB7 PPP2R2B PPP2R2C EGFR SOS1 SOS2

2.18e-04339869M39736
PathwayREACTOME_SIGNALING_BY_NOTCH3

DLL1 EGFR JAG1 NOTCH1

2.22e-0449864M618
PathwayREACTOME_NOTCH2_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS

DLL1 JAG1 NOTCH2

3.10e-0422863M27210
PathwayKEGG_MEDICUS_REFERENCE_CD80_CD86_CTLA4_PP2A_SIGNALING_PATHWAY

PPP2R2D PPP2R2B PPP2R2C

3.10e-0422863M47919
PathwayWP_BREAST_CANCER_PATHWAY

DLL1 EGFR NOTCH1 NOTCH2 SOS1 SOS2

3.53e-04154866M39739
PathwayREACTOME_DEFECTIVE_LFNG_CAUSES_SCDO3

NOTCH1 NOTCH2

3.64e-045862M27411
PathwayWP_NEUROGENESIS_REGULATION_IN_THE_OLFACTORY_EPITHELIUM

VLDLR DLL1 JAG1 NOTCH1

3.99e-0457864M48326
PathwayPID_NOTCH_PATHWAY

DLL1 JAG1 NOTCH1 NOTCH2

4.55e-0459864M17
PathwayREACTOME_NOTCH3_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS

DLL1 EGFR JAG1

4.58e-0425863M27879
PathwayWP_FOCAL_ADHESION_PI3KAKTMTORSIGNALING

FN1 PPP2R2D LAMA2 ITGB7 PPP2R2B PPP2R2C EGFR SOS1

5.04e-04302868M39719
PathwayREACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS

RANBP2 FN1 MYO18A DLL1 TRIM24 EGFR JAG1 FGG NOTCH1 SOS1

5.11e-044648610M27547
PathwayWP_NOTCH_SIGNALING_WP61

DLL1 JAG1 NOTCH1 NOTCH2

5.17e-0461864M39540
PathwayBIOCARTA_NOTCH_PATHWAY

DLL1 NOTCH1

5.43e-046862MM1584
PathwayBIOCARTA_NOTCH_PATHWAY

DLL1 NOTCH1

5.43e-046862M22074
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM

NOTCH1 NOTCH2

5.43e-046862M27068
PathwayREACTOME_INTEGRIN_SIGNALING

FN1 FGG SOS1

5.77e-0427863M760
PathwayWP_NANOPARTICLEMEDIATED_ACTIVATION_OF_RECEPTOR_SIGNALING

FN1 EGFR SOS1

6.43e-0428863M39572
PathwayREACTOME_INTEGRIN_SIGNALING

FN1 FGG SOS1

6.43e-0428863MM14958
PathwayREACTOME_EGFR_TRANSACTIVATION_BY_GASTRIN

EGFR SOS1

7.57e-047862MM14879
PathwayKEGG_MEDICUS_REFERENCE_ITGA_B_TALIN_VINCULIN_SIGNALING_PATHWAY

FN1 ACTN1 ITGB7

7.90e-0430863M47724
PathwayWP_UROTENSINIIMEDIATED_SIGNALING

CYBB FN1 NCF2 EGFR

8.25e-0469864M48052
PathwayWP_FOCAL_ADHESION_PI3KAKTMTOR_SIGNALING_PATHWAY

FN1 PPP2R2D LAMA2 ITGB7 PPP2R2B PPP2R2C EGFR SOS1

8.32e-04326868MM15917
PathwayREACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS

DLL1 JAG1 NOTCH1

8.71e-0431863M592
PathwayWP_FOCAL_ADHESION

FN1 LAMA2 ACTN1 ITGB7 EGFR SOS1

9.82e-04187866MM15913
PathwayREACTOME_REGULATION_OF_CYTOSKELETAL_REMODELING_AND_CELL_SPREADING_BY_IPP_COMPLEX_COMPONENTS

ACTN1 LIMS1

1.01e-038862M27376
PathwayREACTOME_REGULATION_OF_CYTOSKELETAL_REMODELING_AND_CELL_SPREADING_BY_IPP_COMPLEX_COMPONENTS

ACTN1 LIMS1

1.01e-038862MM15124
PathwayREACTOME_CROSS_PRESENTATION_OF_PARTICULATE_EXOGENOUS_ANTIGENS_PHAGOSOMES

CYBB NCF2

1.01e-038862M26926
PathwayWP_CANCER_PATHWAYS

FN1 LAMA2 DLL1 ADCY8 EGFR JAG1 NOTCH1 NOTCH2 SOS1 SOS2

1.01e-035078610M48302
PathwayREACTOME_SIGNALING_BY_NOTCH2

DLL1 JAG1 NOTCH2

1.05e-0333863M604
PathwayREACTOME_PLASMA_LIPOPROTEIN_CLEARANCE

NPC1 VLDLR LDLR

1.14e-0334863MM15566
PathwayREACTOME_EGFR_TRANSACTIVATION_BY_GASTRIN

EGFR SOS1

1.29e-039862M27156
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_LIGAND_UBIQUITYLATION

DLL1 JAG1

1.29e-039862M47866
PathwayWP_SOMITOGENESIS_IN_THE_CONTEXT_OF_SPONDYLOCOSTAL_DYSOSTOSIS

DLL1 NOTCH1

1.29e-039862M39869
PathwayREACTOME_CROSS_PRESENTATION_OF_PARTICULATE_EXOGENOUS_ANTIGENS_PHAGOSOMES

CYBB NCF2

1.29e-039862MM14524
PathwayWP_FOCAL_ADHESION

FN1 LAMA2 ACTN1 ITGB7 EGFR SOS1

1.35e-03199866M39402
PathwayREACTOME_PLASMA_LIPOPROTEIN_CLEARANCE

NPC1 VLDLR LDLR

1.47e-0337863M27847
PathwayWP_GENETIC_CAUSES_OF_PORTOSINUSOIDAL_VASCULAR_DISEASE

CYBB NCF2 NOTCH1

1.47e-0337863M45513
PathwayREACTOME_SIGNALING_BY_FGFR1_IN_DISEASE

MYO18A TRIM24 SOS1

1.59e-0338863M27536
PathwayREACTOME_PLATELET_AGGREGATION_PLUG_FORMATION

FN1 FGG SOS1

1.59e-0338863MM15456
PathwayWP_GENE_REGULATORY_NETWORK_MODELLING_SOMITOGENESIS

DLL1 NOTCH1

1.60e-0310862MM15839
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_PATHWAY_ADAPTOR_PROTEINS

SOS1 SOS2

1.60e-0310862M47930
PathwayREACTOME_PLATELET_AGGREGATION_PLUG_FORMATION

FN1 FGG SOS1

1.71e-0339863M10735
PathwayWP_EGFR_TYROSINE_KINASE_INHIBITOR_RESISTANCE

GAS6 EGFR SOS1 SOS2

1.72e-0384864M39839
PathwayKEGG_REGULATION_OF_ACTIN_CYTOSKELETON

FN1 ACTN1 ITGB7 EGFR SOS1 SOS2

1.91e-03213866M18306
PathwayREACTOME_INTERLEUKIN_15_SIGNALING

SOS1 SOS2

1.95e-0311862MM15578
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_PROTEOLYTIC_ACTIVATION

NOTCH1 NOTCH2

1.95e-0311862M47865
PathwayWP_GENE_REGULATORY_NETWORK_MODELING_SOMITOGENESIS

DLL1 NOTCH1

1.95e-0311862M39647
PathwayWP_HAIR_FOLLICLE_DEVELOPMENT_CYTODIFFERENTIATION_STAGE_3_OF_3

EGFR FST NOTCH1 NOTCH2

1.96e-0387864M39465
PathwayKEGG_GAP_JUNCTION

ADCY8 EGFR SOS1 SOS2

2.21e-0390864M4013
PathwayWP_REGULATION_OF_ACTIN_CYTOSKELETON

FN1 ACTN1 EGFR SOS1 SOS2

2.22e-03150865M39520
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00381

NOTCH1 NOTCH2

2.33e-0312862M47533
PathwayWP_REGULATION_OF_ACTIN_CYTOSKELETON

FN1 ACTN1 EGFR SOS1 SOS2

2.36e-03152865MM15834
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

CAPN12 FN1 CAPN3 LAMA2 ACTN1 ITGB7 FGG

2.36e-03300867M610
PathwayREACTOME_NEPHRON_DEVELOPMENT

DLL1 JAG1

2.75e-0313862M48245
PathwayREACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING

EGFR SOS1

2.75e-0313862MM14701
PathwayREACTOME_ACTIVATION_OF_RAC1

SOS1 SOS2

2.75e-0313862M6322
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00382

NOTCH1 NOTCH2

2.75e-0313862M47534
PathwayWP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY

ADCY8 SOS1 SOS2

2.75e-0346863M39828
PathwayREACTOME_METABOLISM_OF_FAT_SOLUBLE_VITAMINS

LDLR LRP1 LRP2

3.11e-0348863M27642
PathwayKEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

3.19e-0314862M47364
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KIT_TO_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

3.19e-0314862M47365
PathwayKEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

3.19e-0314862M47366
PathwayREACTOME_LGI_ADAM_INTERACTIONS

ADAM23 ADAM11

3.19e-0314862MM15277
Pubmed

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.

VLDLR LRP1B LDLR ITGB7 EGFR LRP1 LRP2 NOTCH1 NOTCH2

4.38e-11101112923382219
Pubmed

Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes.

DLL1 JAG1 NOTCH1 NOTCH2

1.02e-104112422390640
Pubmed

Evolution of Human Brain Size-Associated NOTCH2NL Genes Proceeds toward Reduced Protein Levels.

NOTCH2NLA NOTCH2NLC NOTCH2NLB NOTCH2

1.02e-104112432330268
Pubmed

The notch receptor and its ligands are selectively expressed during hematopoietic development in the mouse.

DLL1 JAG1 NOTCH1 NOTCH2

5.08e-105112411713346
Pubmed

Interaction of coagulation factor VIII with members of the low-density lipoprotein receptor family follows common mechanism and involves consensus residues within the A2 binding site 484-509.

VLDLR LDLR LRP1 LRP2

5.08e-105112418685438
Pubmed

Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis.

NOTCH2NLA NOTCH2NLC NOTCH2NLB NOTCH2

5.08e-105112429856954
Pubmed

Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation.

NOTCH2NLA DLL1 NOTCH2NLC NOTCH2NLB

5.08e-105112429856955
Pubmed

Notch Dosage: Jagged1 Haploinsufficiency Is Associated With Reduced Neuronal Division and Disruption of Periglomerular Interneurons in Mice.

DLL1 EGFR JAG1 NOTCH1 NOTCH2

1.34e-0916112532161758
Pubmed

Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2.

DLL1 JAG1 NOTCH1 NOTCH2

1.52e-096112410958687
Pubmed

Aberrant expression of Notch signaling molecules in patients with immune thrombocytopenic purpura.

DLL1 JAG1 NOTCH1 NOTCH2

1.52e-096112419603167
Pubmed

Regulation of membrane phospholipid asymmetry by Notch-mediated flippase expression controls the number of intraepithelial TCRαβ+CD8αα+ T cells.

DLL1 JAG1 NOTCH1 NOTCH2

1.52e-096112431071093
Pubmed

Human ligands of the Notch receptor.

DLL1 JAG1 NOTCH1 NOTCH2

3.54e-097112410079256
Pubmed

The distribution of Notch receptors and their ligands during articular cartilage development.

DLL1 JAG1 NOTCH1 NOTCH2

3.54e-097112412846471
Pubmed

Differentiation of CD11c+ CX3CR1+ cells in the small intestine requires Notch signaling.

DLL1 JAG1 NOTCH1 NOTCH2

3.54e-097112424711412
Pubmed

The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor.

VLDLR LDLR LRP1 LRP2

3.54e-097112412169628
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

NPC1 VLDLR FN1 ADAM23 GNPTAB ACTN1 ZNF227 NSUN2 LRP1B GFPT1 XAB2 TRIM33 NELL1 GDAP1L1 UBE2O MEGF9 LRP1 LRP2 SOS1 SOS2

5.00e-0912851122035914814
Pubmed

MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.

VLDLR LRP1B LDLR LRP1 LRP2

6.18e-0921112521337463
Pubmed

Expression of Hairy/Enhancer of Split genes, Hes1 and Hes5, during murine nephron morphogenesis.

DLL1 JAG1 NOTCH1 NOTCH2

7.06e-098112415465493
Pubmed

Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear.

DLL1 JAG1 NOTCH1 NOTCH2

7.06e-09811249858718
Pubmed

Notch/Delta expression in the developing mouse lung.

DLL1 JAG1 NOTCH1 NOTCH2

7.06e-098112411044610
Pubmed

Dynamic expression patterns of the pudgy/spondylocostal dysostosis gene Dll3 in the developing nervous system.

DLL1 JAG1 NOTCH1 NOTCH2

1.27e-089112411118901
Pubmed

Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud.

DLL1 JAG1 NOTCH1 NOTCH2

1.27e-089112416245338
Pubmed

Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance.

VLDLR LDLR LRP1 SORL1

1.27e-089112420005821
Pubmed

Spatiotemporal expression of Notch receptors and ligands in developing mouse placenta.

DLL1 JAG1 NOTCH1 NOTCH2

2.11e-0810112423665443
Pubmed

Dynamics of Notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle.

DLL1 JAG1 NOTCH1 NOTCH2

2.11e-0810112424015274
Pubmed

Both Notch1 and its ligands in B cells promote antibody production.

DLL1 JAG1 NOTCH1

3.25e-083112328863329
Pubmed

Cancer stem cell and embryonic development-associated molecules contribute to prognostic significance in ovarian cancer.

DLL1 JAG1 NOTCH1

3.25e-083112322080880
Pubmed

Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells.

JAG1 NOTCH1 NOTCH2

3.25e-083112314726396
Pubmed

Notch signaling confers antigen-presenting cell functions on mast cells.

DLL1 NOTCH1 NOTCH2

3.25e-083112319130928
Pubmed

Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells.

DLL1 NOTCH1 NOTCH2

3.25e-083112315976178
Pubmed

Activation of Notch signal pathway is associated with a poorer prognosis in acute myeloid leukemia.

DLL1 JAG1 NOTCH1

3.25e-083112320812035
Pubmed

The hepatic uptake of VLDL in lrp-ldlr-/-vldlr-/- mice is regulated by LPL activity and involves proteoglycans and SR-BI.

VLDLR LDLR LRP1

3.25e-083112318367731
Pubmed

Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation.

DLL1 JAG1 NOTCH1

3.25e-083112315781650
Pubmed

Localisation of members of the notch system and the differentiation of vibrissa hair follicles: receptors, ligands, and fringe modulators.

DLL1 JAG1 NOTCH1 NOTCH2

3.30e-0811112410878608
Pubmed

Notch-associated gene expression in embryonic and adult taste papillae and taste buds suggests a role in taste cell lineage decisions.

DLL1 JAG1 NOTCH1 NOTCH2

3.30e-0811112412866128
Pubmed

LRP2 mediates folate uptake in the developing neural tube.

FOLR1 LRP1B LRP1 LRP2

3.30e-0811112424639464
Pubmed

Defects in somite formation in lunatic fringe-deficient mice.

DLL1 JAG1 NOTCH1 NOTCH2

3.30e-081111249690472
Pubmed

A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway.

DLL1 JAG1 NOTCH1 NOTCH2

3.30e-081111249187150
Pubmed

Coexpression of Cux-1 and Notch signaling pathway components during kidney development.

DLL1 JAG1 NOTCH1 NOTCH2

3.30e-0811112415499562
Pubmed

Notch signaling regulates ovarian follicle formation and coordinates follicular growth.

DLL1 JAG1 FST NOTCH1 NOTCH2

4.23e-0830112524552588
Pubmed

Developmental regulation of Notch signaling genes in the embryonic pituitary: Prop1 deficiency affects Notch2 expression.

DLL1 JAG1 NOTCH1 NOTCH2

4.94e-0812112414732396
Pubmed

Compartmentalised expression of Delta-like 1 in epithelial somites is required for the formation of intervertebral joints.

DLL1 JAG1 NOTCH1 NOTCH2

4.94e-0812112417572911
Pubmed

Developmental expression of the Notch signaling pathway genes during mouse preimplantation development.

DLL1 JAG1 NOTCH1 NOTCH2

4.94e-0812112415465494
Pubmed

Node and midline defects are associated with left-right development in Delta1 mutant embryos.

DLL1 JAG1 NOTCH1 NOTCH2

7.12e-0813112412441287
Pubmed

Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels.

DLL1 JAG1 NOTCH1 NOTCH2

7.12e-0813112411578869
Pubmed

Jagged1 is Essential for Radial Glial Maintenance in the Cortical Proliferative Zone.

DLL1 JAG1 NOTCH1 NOTCH2

7.12e-0813112431202705
Pubmed

Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.

VLDLR LRP1B LRP1 LRP2

9.95e-0814112415082773
Pubmed

The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney development.

DLL1 JAG1 NOTCH1 NOTCH2

9.95e-0814112423806616
Pubmed

Stage-specific association of apolipoprotein A-I and E in developing mouse retina.

VLDLR LDLR LRP1 LRP2

9.95e-0814112417389516
Pubmed

Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway.

DLL1 JAG1 NOTCH1 NOTCH2

9.95e-0814112414757642
Pubmed

The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor.

VLDLR LDLR LRP1

1.30e-074112315863833
Pubmed

Notch pathway regulates female germ cell meiosis progression and early oogenesis events in fetal mouse.

JAG1 NOTCH1 NOTCH2

1.30e-074112324398584
Pubmed

Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2.

DLL1 NOTCH1 NOTCH2

1.30e-074112332820046
Pubmed

Evolution and cell-type specificity of human-specific genes preferentially expressed in progenitors of fetal neocortex.

NOTCH2NLA NOTCH2NLC NOTCH2NLB

1.30e-074112329561261
Pubmed

Jagged1/Notch2 controls kidney fibrosis via Tfam-mediated metabolic reprogramming.

JAG1 NOTCH1 NOTCH2

1.30e-074112330226866
Pubmed

Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods.

JAG1 NOTCH1 NOTCH2

1.30e-074112310551863
Pubmed

Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane.

DLL1 NOTCH1 NOTCH2

1.30e-07411239244302
Pubmed

Developmental regulation of LR11 expression in murine brain.

VLDLR LDLR SORL1

1.30e-07411239726247
Pubmed

The Notch signalling pathway in hair growth.

DLL1 JAG1 NOTCH1

1.30e-07411239858728
Pubmed

LDL receptor cooperates with LDL receptor-related protein in regulating plasma levels of coagulation factor VIII in vivo.

VLDLR LDLR LRP1

1.30e-074112315840700
Pubmed

Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor.

DLL1 JAG1 NOTCH1

1.30e-07411239315665
Pubmed

No evidence for a functional role of bi-directional Notch signaling during angiogenesis.

DLL1 JAG1 NOTCH1

1.30e-074112323300864
Pubmed

Notch controls the survival of memory CD4+ T cells by regulating glucose uptake.

DLL1 NOTCH1 NOTCH2

1.30e-074112325501905
Pubmed

Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development.

DLL1 JAG1 NOTCH1 NOTCH2

1.35e-0715112412971992
Pubmed

Second-generation Notch1 activity-trap mouse line (N1IP::CreHI) provides a more comprehensive map of cells experiencing Notch1 activity.

DLL1 JAG1 UMOD NOTCH1

1.35e-0715112425725069
Pubmed

COUP-TFI controls Notch regulation of hair cell and support cell differentiation.

DLL1 JAG1 NOTCH1 NOTCH2

1.35e-0715112416914494
Pubmed

Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth.

DLL1 JAG1 NOTCH1 NOTCH2

1.35e-0715112412167404
Pubmed

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

RPS8 TRIM24 LDLR TRIM33 SCN9A LRP1 NOTCH1 NOTCH2

1.57e-07184112832908313
Pubmed

An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.

DLL1 JAG1 NOTCH1 NOTCH2

1.80e-0716112417273555
Pubmed

The Cellular Prion Protein Controls Notch Signaling in Neural Stem/Progenitor Cells.

EGFR JAG1 NOTCH1 NOTCH2

1.80e-0716112427641601
Pubmed

Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron.

DLL1 JAG1 NOTCH1 NOTCH2

1.80e-0716112417229764
Pubmed

Notch gene expression during pancreatic organogenesis.

DLL1 JAG1 NOTCH1 NOTCH2

1.80e-0716112410842072
Pubmed

Expression of Notch pathway components in fetal and adult mouse small intestine.

DLL1 JAG1 NOTCH1 NOTCH2

1.80e-0716112412617809
Pubmed

HNF1B controls proximal-intermediate nephron segment identity in vertebrates by regulating Notch signalling components and Irx1/2.

DLL1 JAG1 LRP2 NOTCH1 NOTCH2

1.90e-0740112523362348
Pubmed

Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung.

DLL1 JAG1 NOTCH1 NOTCH2

2.35e-0717112418694942
Pubmed

Notch signalling controls pancreatic cell differentiation.

DLL1 JAG1 NOTCH1 NOTCH2

2.35e-0717112410476967
Pubmed

Segmental expression of Notch and Hairy genes in nephrogenesis.

DLL1 JAG1 NOTCH1 NOTCH2

2.35e-0717112415821257
Pubmed

Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.

VLDLR LDLR LRP1 LRP2

3.01e-0718112410827173
Pubmed

RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells.

DLL1 JAG1 NOTCH1 NOTCH2

3.01e-0718112415689374
Pubmed

Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling.

DLL1 JAG1 NOTCH1 NOTCH2

3.01e-0718112418093989
Pubmed

Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development.

EGFR SOS1 SOS2

3.24e-07511239030684
Pubmed

Botch promotes neurogenesis by antagonizing Notch.

DLL1 EGFR NOTCH1

3.24e-075112322445366
Pubmed

Notch1 and its ligands Delta-like and Jagged are expressed and active in distinct cell populations in the postnatal mouse brain.

DLL1 JAG1 NOTCH1

3.24e-075112312175503
Pubmed

Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11.

LRP1 LRP2 SORL1

3.24e-075112319047013
Pubmed

Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells.

DLL1 JAG1 NOTCH1

3.24e-075112319682396
Pubmed

Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors.

DLL1 JAG1 NOTCH1

3.24e-075112311006133
Pubmed

Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation.

DLL1 JAG1 NOTCH2

3.24e-075112311346656
Pubmed

Critical Role of SREBP-1c Large-VLDL Pathway in Environment-Induced Hypertriglyceridemia of Apo AV Deficiency.

VLDLR LDLR LRP1

3.24e-075112330700132
Pubmed

Notch signaling mediated by Delta-like ligands 1 and 4 controls the pathogenesis of chronic GVHD in mice.

DLL1 NOTCH1 NOTCH2

3.24e-075112330181175
Pubmed

Normal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemia.

VLDLR LDLR LRP1

3.24e-075112312746448
Pubmed

Apolipoprotein CI inhibits scavenger receptor BI and increases plasma HDL levels in vivo.

VLDLR LDLR LRP1

3.24e-075112318992221
Pubmed

Association of Notch pathway down-regulation with Triple Negative/Basal-like breast carcinomas and high tumor-infiltrating FOXP3+ Tregs.

JAG1 NOTCH1 NOTCH2

3.24e-075112327118257
Pubmed

Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearance.

VLDLR LDLR LRP1

3.24e-075112323959870
Pubmed

Immunohistochemical expression of Notch signaling in the lining epithelium of periapical cysts.

DLL1 NOTCH1 NOTCH2

3.24e-075112321238798
Pubmed

Squamous odontogenic tumor of the mandible: a case report demonstrating immunoexpression of Notch1, 3, 4, Jagged1 and Delta1.

DLL1 JAG1 NOTCH1

3.24e-075112320554499
Pubmed

Cloning of a complementary deoxyribonucleic acid encoding the murine homolog of the very low density lipoprotein/apolipoprotein-E receptor: expression pattern and assignment of the gene to mouse chromosome 19.

VLDLR LDLR LRP1

3.24e-07511238013374
Pubmed

Functional diversity of notch family genes in fetal lung development.

JAG1 NOTCH1 NOTCH2

3.24e-075112315064243
Pubmed

Functional redundancy of the Notch gene family during mouse embryogenesis: analysis of Notch gene expression in Notch3-deficient mice.

JAG1 NOTCH1 NOTCH2

3.24e-075112315882997
Pubmed

Two distinct Notch signals, Delta-like 4/Notch1 and Jagged-1/Notch2, antagonistically regulate chemical hepatocarcinogenesis in mice.

JAG1 NOTCH1 NOTCH2

3.24e-075112335064244
Pubmed

RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development.

DLL1 JAG1 NOTCH1 NOTCH2

3.80e-0719112420335360
InteractionNTN5 interactions

LRP1B LDLR LRP2 NOTCH1 NOTCH2 SORL1

2.86e-09241106int:NTN5
InteractionIGFL3 interactions

VLDLR ADAM11 LRP1B LDLR LRP2 NOTCH1 NOTCH2 SORL1

7.58e-09751108int:IGFL3
InteractionFOXD4L6 interactions

PPP2R2D LRP1B LDLR EGFR NOTCH1 NOTCH2 SORL1

8.46e-09491107int:FOXD4L6
InteractionZFP41 interactions

LRP1B LDLR UBE2O LRP1 LRP2 NOTCH2 SORL1

2.51e-08571107int:ZFP41
InteractionDAB1 interactions

VLDLR LDLR ITGB7 EGFR LRP1 LRP2 C1orf94 NOTCH1

1.27e-071071108int:DAB1
InteractionZNF408 interactions

VLDLR NOTCH2NLA LRP1B LDLR KRT40 LRP2 NOTCH2 SORL1

1.31e-061451108int:ZNF408
InteractionIER2 interactions

RANBP2 PPP2R2D KDM5C PPP2R2B PPP2R2C

1.68e-06371105int:IER2
InteractionCLEC18A interactions

PPP2R2D KRT34 NOTCH2NLA KRT40

1.89e-06171104int:CLEC18A
InteractionLGALS1 interactions

NPC1 FN1 GNPTAB LDLR MEGF9 EGFR JAG1 LRP2 NOTCH1 NOTCH2 SORL1

2.05e-0633211011int:LGALS1
InteractionFBXO2 interactions

NPC1 FN1 ADAM23 GNPTAB GAS6 LRP1B EGFR JAG1 LRP2 NOTCH1 NOTCH2 SORL1

2.56e-0641111012int:FBXO2
InteractionSERTAD4 interactions

PPP2R2D PPP2R2B PPP2R2C EGFR

3.06e-06191104int:SERTAD4
InteractionCCN6 interactions

LDLR NOTCH1 NOTCH2 SORL1

3.06e-06191104int:CCN6
InteractionEGFL6 interactions

LRP1B LDLR LRP2 SORL1

4.68e-06211104int:EGFL6
InteractionWNT3A interactions

PPP2R2D LDLR LRP1 NOTCH1 NOTCH2

6.96e-06491105int:WNT3A
InteractionTIMP3 interactions

LRP1B LDLR NELL1 LRP2 NOTCH2 SORL1

9.89e-06901106int:TIMP3
InteractionZNF319 interactions

KRT34 NOTCH2NLA EGFR KRT40

1.34e-05271104int:ZNF319
InteractionMFNG interactions

DLL1 JAG1 NOTCH1 NOTCH2

1.34e-05271104int:MFNG
InteractionFEZF1 interactions

LRP1B KRT40 LRP2 SORL1

1.56e-05281104int:FEZF1
InteractionZNF517 interactions

LRP1B UBE2O LRP2 SORL1

1.80e-05291104int:ZNF517
InteractionANKRD36B interactions

VLDLR LRP1B LRP1 LRP2 SORL1

1.90e-05601105int:ANKRD36B
InteractionPABIR1 interactions

PPP2R2D LDLR PPP2R2B PPP2R2C

2.36e-05311104int:PABIR1
InteractionEDN3 interactions

GAS6 LDLR SEMA3B NOTCH1 NOTCH2 SORL1

2.81e-051081106int:EDN3
InteractionHBA1 interactions

FN1 FOLR1 KRT34 NOTCH2NLA EGFR

3.26e-05671105int:HBA1
InteractionZNF563 interactions

LRP1B UBE2O SORL1

3.36e-05121103int:ZNF563
InteractionZNF672 interactions

NOTCH2NLA UBE2O NOTCH2

3.36e-05121103int:ZNF672
InteractionCOL17A1 interactions

RANBP2 ACTN1 UBE2O EGFR

3.43e-05341104int:COL17A1
InteractionIER5 interactions

PPP2R2D PPP2R2B PPP2R2C

4.35e-05131103int:IER5
InteractionGREM2 interactions

LDLR LRP2 NOTCH2 SORL1

4.83e-05371104int:GREM2
InteractionPRR19 interactions

KRT34 NOTCH2NLA EGFR

5.51e-05141103int:PRR19
InteractionIGSF5 interactions

LDLR NOTCH1 NOTCH2

5.51e-05141103int:IGSF5
InteractionLRPAP1 interactions

VLDLR RANBP2 LRP1B LDLR LRP1 LRP2 SORL1

5.92e-051801107int:LRPAP1
InteractionCCN2 interactions

LIMS1 EGFR LRP1 LRP2

6.60e-05401104int:CCN2
InteractionTAFA3 interactions

PPP2R2D LRP1B LDLR LRP2 SORL1

6.80e-05781105int:TAFA3
InteractionDEFB123 interactions

LRP1B LDLR SORL1

8.41e-05161103int:DEFB123
InteractionTFPI2 interactions

IFT22 UBE2O EGFR SORL1

8.80e-05431104int:TFPI2
InteractionLRP1B interactions

LRP1B LDLR LRP1 LRP2 FGG

1.02e-04851105int:LRP1B
InteractionKDM5C interactions

MBTD1 KDM5C ACTN1 LDLR SPATA1 TRIM33

1.15e-041391106int:KDM5C
InteractionDAB2 interactions

FN1 MYO18A LDLR EGFR LRP1 LRP2

1.20e-041401106int:DAB2
InteractionMDK interactions

UBE2O LRP1 LRP2 NOTCH2 SORL1

1.42e-04911105int:MDK
InteractionTAPBPL interactions

KRT34 NOTCH2NLA KRT40

1.44e-04191103int:TAPBPL
InteractionDKK2 interactions

LRP1B LRP2 NOTCH1 SORL1

1.47e-04491104int:DKK2
InteractionZNF224 interactions

LRP1B LRP2 SORL1

1.69e-04201103int:ZNF224
InteractionNPBWR2 interactions

KRT34 NOTCH2NLA KRT40

1.69e-04201103int:NPBWR2
InteractionFGA interactions

FN1 LRP1B TRIM33 PPP2R2B FGG

1.73e-04951105int:FGA
InteractionZNF486 interactions

ZNF486 LDLR

1.76e-0441102int:ZNF486
InteractionSMAD9 interactions

FN1 XAB2 PPP2R2C PAPPA NOTCH1 TBCD

1.94e-041531106int:SMAD9
InteractionGARIN6 interactions

KRT34 NOTCH2NLA KRT40

1.96e-04211103int:GARIN6
InteractionHBZ interactions

FN1 NOTCH2NLA MYO18A KRT40

2.15e-04541104int:HBZ
InteractionAPOB interactions

ACTN1 LDLR NELL1 UBE2O EGFR LRP2

2.16e-041561106int:APOB
InteractionSIRPA interactions

KRT34 RPS8 ACTN1 KRT40 SOS1

2.20e-041001105int:SIRPA
InteractionLINC01588 interactions

KDM5C UBE2O KRT40

2.26e-04221103int:LINC01588
InteractionMXI1 interactions

KDM5C NOTCH2NLA UBE2O KRT40

2.31e-04551104int:MXI1
InteractionWNT2 interactions

NOTCH1 NOTCH2 SORL1

2.59e-04231103int:WNT2
InteractionSEC61B interactions

VLDLR FN1 SCARF2 RPS8 FNDC3A GBA2 LRP1B UBE2O EGFR LRP2 POFUT2 NOTCH1 NOTCH2

2.67e-0476311013int:SEC61B
InteractionFGG interactions

FN1 LRP1B PPP2R2B UBE2O FGG

2.77e-041051105int:FGG
InteractionWDR25 interactions

KRT34 NOTCH2NLA EGFR KRT40

2.84e-04581104int:WDR25
InteractionMAPK8IP1 interactions

MYO18A EGFR LRP1 LRP2

2.84e-04581104int:MAPK8IP1
InteractionADAM12 interactions

ADAM23 NOTCH2NLA ADAM11 FST

2.84e-04581104int:ADAM12
InteractionBTBD18 interactions

TRIM33 EGFR

2.92e-0451102int:BTBD18
InteractionSCARF2 interactions

SCARF2 SCARF1 NOTCH2

2.95e-04241103int:SCARF2
InteractionHBA2 interactions

FN1 KRT34 NOTCH2NLA EGFR KRT40

3.02e-041071105int:HBA2
InteractionRPS28 interactions

FN1 FOLR1 RPS8 NOTCH2NLA TRIM24 UBE2O EGFR LRP2

3.43e-043161108int:RPS28
InteractionAPOE interactions

VLDLR LDLR LRP1 LRP2 FGG SORL1

3.53e-041711106int:APOE
InteractionSLC23A1 interactions

KRT34 NOTCH2NLA KRT40

3.75e-04261103int:SLC23A1
InteractionNOTCH3 interactions

DLL1 CBFA2T2 JAG1 NOTCH1 NOTCH2

3.89e-041131105int:NOTCH3
InteractionPLAT interactions

FN1 LRP1B LRP1 NOTCH2

3.91e-04631104int:PLAT
InteractionZNF331 interactions

GGNBP2 TRIM24 LRP1B SORL1

3.91e-04631104int:ZNF331
InteractionCLU interactions

VLDLR ACTN1 LRP1B CD209 EGFR LRP1 LRP2

3.96e-042451107int:CLU
InteractionPID1 interactions

NOTCH2NLA EGFR LRP1

4.21e-04271103int:PID1
InteractionADAMTS9 interactions

LIMS1 NOTCH2

4.37e-0461102int:ADAMTS9
InteractionCDK5R1 interactions

VLDLR NOTCH2NLA ACTN1 KRT40

4.40e-04651104int:CDK5R1
InteractionKLK10 interactions

CYBB FN1 NCF2 PPP2R2B FGG SLC37A4

4.64e-041801106int:KLK10
InteractionTAB1 interactions

USP18 FN1 NAIP TRIM24 UBE2O EGFR NOTCH1

4.69e-042521107int:TAB1
InteractionCDH16 interactions

GAS6 TRIM24 EGFR

4.69e-04281103int:CDH16
InteractionLDLR interactions

VLDLR MBTD1 ZNF486 KDM5C NSUN2 LRP1B LDLR XAB2 LIMS1

4.70e-044171109int:LDLR
InteractionACLY interactions

FN1 PPP2R2D NSUN2 TRIM33 PPP2R2B PPP2R2C UBE2O EGFR

5.05e-043351108int:ACLY
GeneFamilyLow density lipoprotein receptors

VLDLR LRP1B LDLR LRP1 LRP2

2.26e-0913835634
GeneFamilyC2-set domain containing|Immunoglobulin like domain containing|Scavenger receptors

SCARF2 CD209 SCARF1 CD163L1

6.69e-06278341253
GeneFamilyWD repeat domain containing|Protein phosphatase 2 regulatory subunits

PPP2R2D PPP2R2B PPP2R2C

4.08e-0515833696
GeneFamilyPHD finger proteins

KDM5C TRIM24 TRIM33 BAZ2A

7.82e-049083488
GeneFamilyRing finger proteins|Tripartite motif containing|ARF GTPase family

TRIM43 TRIM24 TRIM43B TRIM33

9.57e-049583459
GeneFamilyC2 domain containing|Calpains

CAPN12 CAPN3

2.10e-0315832975
GeneFamilyIntraflagellar transport proteins|Tetratricopeptide repeat domain containing

IFT22 WDR35

5.38e-0324832615
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF486 ZNF337 ZNF208 ZNF227 ZNF248 ZNF728 ZFHX3 ZNF454 ZNF345

5.58e-0371883928
GeneFamilyNLR family

NAIP NLRP10

5.83e-0325832666
GeneFamilyADAM metallopeptidase domain containing|CD molecules

ADAM23 ADAM11

6.78e-032783247
GeneFamilyWD repeat domain containing

PPP2R2D PPP2R2B PPP2R2C EML5 WDR35

7.13e-03262835362
GeneFamilyKeratins, type I

KRT34 KRT40

7.28e-0328832608
CoexpressionFUKUSHIMA_TNFSF11_TARGETS

DLL1 JAG1 NOTCH1 NOTCH2

5.14e-07161104MM1296
CoexpressionFUKUSHIMA_TNFSF11_TARGETS

DLL1 JAG1 NOTCH1 NOTCH2

5.14e-07161104M2207
CoexpressionNABA_MATRISOME

BRINP3 FN1 SPOCK1 SFTPD ADAM23 GAS6 LAMA2 ADAM11 CD209 PTN NELL1 MEGF9 SEMA3B PAPPA FGG FST MEGF11

1.03e-06100811017MM17056
CoexpressionNABA_MATRISOME

BRINP3 FN1 SPOCK1 SFTPD ADAM23 GAS6 LAMA2 ADAM11 CD209 PTN NELL1 MEGF9 SEMA3B PAPPA FGG FST MEGF11

1.31e-06102611017M5889
CoexpressionBRUNEAU_HEART_GREAT_VESSELS_AND_VALVULOGENESIS

JAG1 NOTCH1 NOTCH2

3.97e-0681103M9884
CoexpressionHALLMARK_NOTCH_SIGNALING

DLL1 JAG1 NOTCH1 NOTCH2

9.64e-06321104M5903
CoexpressionDAVICIONI_MOLECULAR_ARMS_VS_ERMS_UP

NPC1 GGNBP2 MYO18A ZNF248 NELL1 MEGF9 NOTCH1 TBCD SOS2

1.38e-053401109M2012
CoexpressionBOQUEST_STEM_CELL_UP

SPOCK1 NOTCH2NLA LAMA2 LRP1B EGFR LRP1 FST NOTCH2

1.48e-052611108M1834
CoexpressionHASINA_NOL7_TARGETS_DN

CD55 EGFR JAG1

1.99e-05131103M596
CoexpressionGSE17721_LPS_VS_PAM3CSK4_16H_BMDC_UP

FNDC3A TXNDC17 ACTN1 ZNF227 ITGB7 NFKBIB SORL1

2.22e-052001107M3927
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HNBGABA

ACSL6 BRINP3 SPOCK1 ADAM23 GNPTAB LRP1B ZNF248 NELL1 PPP2R2C EML5 SCN9A ZFHX3

4.03e-0570311012M39070
CoexpressionFOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_DN

CYBB SPIRE2 NOTCH2NLA LDLRAD3 PTN BAZ2A LRP1 ZFHX3 FGG NOTCH2 TBCD SOS2

7.12e-0574611012M40863
CoexpressionRUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_DN

SPOCK1 GAS6 LDLR GFPT1 CD209 JAG1 SORL1

9.12e-052501107M13333
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HSERT

ACSL6 BRINP3 SPOCK1 LRP1B NELL1 PPP2R2B GDAP1L1 SCN9A ZFHX3

1.20e-044501109M39072
CoexpressionDESCARTES_FETAL_MUSCLE_SCHWANN_CELLS

ADAM23 LRP1B PPP2R2B MEGF9 SEMA3B

1.32e-041161105M40251
CoexpressionMEBARKI_HCC_PROGENITOR_WNT_UP_CTNNB1_INDEPENDENT

FN1 SPOCK1 PPP2R2C

1.36e-04241103M38986
CoexpressionZHANG_GATA6_TARGETS_DN

TSPAN11 LDLR SLCO4C1 EGFR

1.45e-04631104M1778
CoexpressionZHANG_GATA6_TARGETS_DN

TSPAN11 LDLR SLCO4C1 EGFR

1.63e-04651104MM1226
CoexpressionAZARE_NEOPLASTIC_TRANSFORMATION_BY_STAT3_UP

FN1 SPOCK1 JAG1 FST SORL1

1.94e-041261105M2309
CoexpressionGSE360_L_DONOVANI_VS_B_MALAYI_LOW_DOSE_MAC_DN

ADAM23 ACTN1 LDLR SCN9A ZFHX3 POFUT2

1.98e-041991106M5240
CoexpressionGSE16266_LPS_VS_HEATSHOCK_AND_LPS_STIM_MEF_UP

CAPN3 TXNDC17 ZNF227 SYT10 CD209 SORL1

1.98e-041991106M7210
CoexpressionGSE23502_WT_VS_HDC_KO_MYELOID_DERIVED_SUPPRESSOR_CELL_BM_UP

GGNBP2 LDLRAD3 LDLR ZPBP2 NOTCH2 SORL1

2.03e-042001106M8090
CoexpressionGSE29618_MONOCYTE_VS_MDC_UP

CYBB NCF2 LDLR LRP1 NOTCH2 SORL1

2.03e-042001106M4948
CoexpressionGSE29618_PDC_VS_MDC_DAY7_FLU_VACCINE_DN

NAIP NCF2 ACTN1 ITGB7 LIMS1 MEGF9

2.03e-042001106M4971
CoexpressionCOLIN_PILOCYTIC_ASTROCYTOMA_VS_GLIOBLASTOMA_DN

FN1 TRIM24 EGFR

2.18e-04281103M14859
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HGABA

ACSL6 SPOCK1 ADAM23 GNPTAB LRP1B ZNF248 NELL1 PPP2R2B PPP2R2C GDAP1L1 MEGF9 SCN9A PAPPA ZFHX3

2.20e-04110611014M39071
CoexpressionDESCARTES_FETAL_ADRENAL_SCHWANN_CELLS

TSPAN11 ADAM23 EXTL1 SYT10 PPP2R2B

2.24e-041301105M40147
ToppCellfacs-Bladder-nan-3m-Epithelial-bladder_mesenchymal_cell_(Car3+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSPAN11 FN1 ADAM23 SCARF2 GAS6 LAMA2 ACTN1 PTN PAPPA

1.68e-09195112918b01ab63ee1deae3cf29669d66fff9ca4efc5c4
ToppCellLA-14._Fibroblast_III|LA / Chamber and Cluster_Paper

SPOCK1 LAMA2 CD55 LDLR EGFR PAPPA ZFHX3 FST

3.22e-0819311287426c291bac59e539c427bcaae18abc7d397d44e
ToppCellCOVID-19-Heart-Fib_1|Heart / Disease (COVID-19 only), tissue and cell type

FN1 SPOCK1 LAMA2 LDLRAD3 PTN EGFR LRP1 NOTCH2

3.49e-081951128f423baa36ac7cdc383c033e35a7d17e6bf913323
ToppCellfacs-Thymus-Thymus_Epithelium|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSPAN11 GAS6 LAMA2 PTN EGFR JAG1 LRP1 LRP2

3.63e-0819611286bc1187dfc4860a4e09032d7ea87ba3d9fe9f363
ToppCellfacs-Thymus-Thymus_Epithelium-18m|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSPAN11 GAS6 LAMA2 PTN EGFR JAG1 LRP1 LRP2

3.63e-081961128c8c89e469402e11aa2a9561e859b6fd1fb66c39b
ToppCellTracheal-10x5prime-Stromal-Schwann-Schwann_nonmyelinating|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

TSPAN11 ADAM23 EXTL1 SYT10 PPP2R2B MEGF9 SEMA3B SCN9A

3.77e-081971128e239caae24f40564a24ad909754f5436f767ccdb
ToppCellCOVID-19_Mild-Classical_Monocyte|COVID-19_Mild / Disease condition and Cell class

CYBB NAIP NCF2 ACTN1 LDLR MEGF9 LRP1 SORL1

3.93e-08198112830ada3de865b6fb2b14196a1cbfd4740c6a57ce3
ToppCellBronchus_Control_(B.)-Immune-TX-MoAM-2|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

CYBB GAS6 NAIP NCF2 CD209 CD163L1 SCN9A LRP1

4.08e-081991128fb63885273d906a85fef178d859d20a311eb8a72
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_granulocytic|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CYBB CD55 NCF2 ACTN1 SLCO4C1 MEGF9 SORL1 SOS2

4.08e-081991128b7af2b4fe6866cc8c78cf0f78390aab1b1b389ba
ToppCellSigmoid-Macrophage-Macrophage|Sigmoid / Region, Cell class and subclass

CYBB NAIP NCF2 ACTN1 CD209 CD163L1 LRP1 ZFHX3

4.24e-0820011289ee3a799de7bade1bfe94b6827461633f02bc1dc
ToppCellSigmoid-(6)_Macrophage-(60)_Macrophage|Sigmoid / shred on region, Cell_type, and subtype

CYBB NAIP NCF2 ACTN1 CD209 CD163L1 LRP1 ZFHX3

4.24e-082001128ad84a83a5a1893f7b053d39eddeca851463a8ff0
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_granulocytic-neutrophil|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CYBB CD55 NCF2 ACTN1 SLCO4C1 MEGF9 SORL1 SOS2

4.24e-082001128808571d74bb5c4d765ff13fc9393f88020d4e90d
ToppCellfacs-Brain_Myeloid-Cortex-3m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYBB FN1 LDLRAD3 LDLR ITGB7 JAG1 LRP2

1.23e-0715311270ef7c45cdd854c79e527006034029767f8e108b2
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA2 LRP1B PKHD1L1 ADCY8 CRB1 LRP2 C1orf94

1.67e-071601127c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA2 LRP1B PKHD1L1 ADCY8 CRB1 LRP2 C1orf94

1.67e-07160112725c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPIRE2 ADAM23 ADAM11 PTN PPP2R2B SEMA3B PAPPA

3.71e-071801127d9c9399df3e2d9f23dbbfffb6cbe8404bf01e2b7
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPIRE2 ADAM23 ADAM11 PTN PPP2R2B SEMA3B PAPPA

3.71e-071801127dad458398683ff80a6e207bdc08e257d1bb757d6
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TSPAN11 LAMA2 SYT10 PPP2R2B MEGF9 SCN9A FST

3.71e-07180112738490017dd590e3fcfa7e88d8d15235d55f90cf1
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPIRE2 ADAM23 ADAM11 PTN PPP2R2B SEMA3B PAPPA

4.00e-071821127812ff2a50a510b18d865e89465dba1754a08ef61
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

SPOCK1 GAS6 PKHD1L1 SYT10 PPP2R2C SEMA3B PAPPA

4.80e-0718711278e8f1f2a78ac5f13a414fd448af7d7ff1ea86f0f
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

SFTPD GAS6 PKHD1L1 SYT10 SEMA3B LRP2 PAPPA

5.54e-0719111274c4eb61e6179d2f8fc524d2f813db9cba84f67a2
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_naive-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CYBB NAIP NOTCH2NLA CD55 NCF2 LOXHD1 MEGF9

5.54e-07191112763d4226a8b59f648bdc9f41e4b2d750dfa342034
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

NPC1 FNDC3A ACTN1 LDLRAD3 LDLR EGFR FGG

5.73e-0719211278b86db2ebe0199fee0e9800566a619a24bfdeed5
ToppCellfacs-Aorta-Heart-3m-Mesenchymal|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VLDLR FN1 SCARF2 CD55 EGFR SEMA3B SORL1

5.73e-0719211270dc1f46e40346ed0b286e53b106a812441575100
ToppCellLA|World / Chamber and Cluster_Paper

FN1 SPOCK1 LRP1B EGFR LRP1 LRP2 ZFHX3

5.94e-071931127d4bf89437216baf489ea0239136dcedf3b6714af
ToppCellCOVID-19-Heart-Fib_2|Heart / Disease (COVID-19 only), tissue and cell type

FN1 SPOCK1 LAMA2 EGFR LRP1 PAPPA NOTCH2

6.15e-071941127d91c9f2ec47319051fc398320693fddbe8bbd4d6
ToppCellMonocytes-M2-like_CD16+_macrophages|World / Immune cells in Kidney/Urine in Lupus Nephritis

CYBB GAS6 CD209 SCARF1 CD163L1 LRP1 ZFHX3

6.36e-07195112710fa47bdcf6c9784ea930b75a5861e139421feed
ToppCellwk_08-11-Mesenchymal-Mesothelial|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SPOCK1 SFTPD GAS6 PKHD1L1 SYT10 PPP2R2C PAPPA

6.36e-0719511279016a44b521214546a55a822ebdef5b5312206d2
ToppCelldroplet-Bladder-nan-3m-Epithelial-bladder_mesenchymal_cell_(Car3+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSPAN11 FN1 ADAM23 SCARF2 GAS6 LAMA2 PAPPA

6.36e-071951127095b8e0be385b6390420589124a95fa4ba3682ab
ToppCellTracheal-10x5prime-Stromal-Schwann|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

TSPAN11 SFTPD ADAM23 EXTL1 SYT10 SEMA3B SCN9A

6.58e-071961127b6226163d9fc93ecfff2115bb74408303a000490
ToppCellBronchial-NucSeq-Stromal-Schwann|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TSPAN11 ADAM23 SYT10 PTN PPP2R2B SEMA3B FST

6.58e-071961127a90c76d9c57a4491b94a321ba541b792ec5d8e83
ToppCellBL-critical-LOC-Myeloid|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CYBB NAIP CD55 NCF2 ACTN1 SCARF1 SORL1

6.81e-071971127932a7fae4979b561688e6222505df0f4e510ab11
ToppCell(3)_Macrophage_MARCOneg|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

CYBB GAS6 NAIP NCF2 CD209 NELL1 CD163L1

6.81e-071971127b0ee2ce1179b60b4542559acb300a34295277dbc
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CYBB FN1 NAIP NCF2 CD209 CD163L1 LRP1

6.81e-071971127dc56bb758c7c5bd151be66f8f3b7078d085f72c7
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CYBB FN1 NAIP NCF2 CD209 CD163L1 LRP1

6.81e-0719711272efb5acd56b96e5afd8d72b927f1d53cc443766f
ToppCellBronchial-NucSeq-Stromal-Schwann-Schwann_nonmyelinating|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TSPAN11 ADAM23 SYT10 PTN PPP2R2B SEMA3B FST

6.81e-0719711274a7ff67bb0754e034e6f2a1bd34cde86ee3ef899
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_monocytic|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CYBB TSPAN11 NAIP SYT10 MEGF9 SEMA3B PAPPA

6.81e-0719711277870c0651caefb0ed13d9f9dab43b5f24d6a9efc
ToppCell10x3'2.3-week_14-16-Myeloid_neutrophil-granulo-neutrophil|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

CYBB NAIP CD55 NCF2 SLCO4C1 MEGF9 SORL1

7.05e-0719811279b29232c8b4dcbd81f450f47c3f79bf26c8fb583
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SPOCK1 EXTL1 LRP1B LDLR SCN9A LRP1 MEGF11

7.29e-07199112719a97e27a4758e794ce7246d295e112b47931a48
ToppCellTracheal-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

TSPAN11 FN1 LAMA2 DLL1 PTN LRP1 PAPPA

7.54e-0720011278ab0051544ea32eb8b3f7f8ba7582deaf8bf26c0
ToppCellSigmoid-Macrophage|Sigmoid / Region, Cell class and subclass

CYBB NAIP NCF2 CD209 CD163L1 LRP1 ZFHX3

7.54e-072001127b07ac0ff3b8530e99094678fed80f35949cafac8
ToppCellParenchymal-10x3prime_v2-Stromal-Fibroblastic-Fibro_myofibroblast|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

BRINP3 FN1 GAS6 LAMA2 LRP1 PAPPA FST

7.54e-072001127251fd2923f108cd2086961d897244b392c32ad54
ToppCellSigmoid-(6)_Macrophage|Sigmoid / shred on region, Cell_type, and subtype

CYBB NAIP NCF2 CD209 CD163L1 LRP1 ZFHX3

7.54e-0720011279e10cca4429de2c4c8c3c6cf2c9e28637a095be9
ToppCell10x5'-bone_marrow-Myeloid_Monocytic-Cycling_mono|bone_marrow / Manually curated celltypes from each tissue

CYBB GAS6 NAIP NCF2 MEGF9 LRP1

2.05e-061481126de35eeefad0e27a0d127e2e4bedead2bddb75152
ToppCell390C-Myeloid-Macrophage-SPP1+_Macrophage_3|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

SPIRE2 SCARF2 NCF2 LDLRAD3 SCARF1 SEMA3B

2.14e-06149112613b445c13bb8f31ff0876addd1baf969ae220ea3
ToppCell5'-Adult-Appendix-Epithelial-Tuft-related-BEST4+_epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VLDLR BRINP3 NOTCH2NLA TRIM24 NOTCH2NLB NOTCH2

2.69e-0615511265fabe24a784f0be46040ffc886eabd8d5ce78121
ToppCellfacs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FN1 SPOCK1 ADAM23 PKHD1L1 UBE2O LRP1

3.23e-06160112656e6f4b82b5dc41c45f9d253c2db314a6f702b84
ToppCellfacs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FN1 SPOCK1 ADAM23 PKHD1L1 UBE2O LRP1

3.23e-061601126bb1b966fb9e801db15e67d03e49db4609d6f935a
ToppCellControl-Myeloid-MoAM1,_IL1R2|Control / Condition, Lineage and Cell class

USP18 SCARF2 GAS6 NAIP LAMA2 SLCO4C1

4.13e-061671126ab6029ba037b6a499da8758864c44e174cde5587
ToppCellControl-Myeloid-MoAM1,_IL1R2|Myeloid / Condition, Lineage and Cell class

USP18 SCARF2 GAS6 NAIP LAMA2 SLCO4C1

4.13e-0616711266e5140527437193f441ca96893b9a00d346614f3
ToppCell10x5'-GI_small-bowel-Lymphocytic_Invariant-Inducer-like|GI_small-bowel / Manually curated celltypes from each tissue

LDLRAD3 DLL1 SCARF1 JAG1 KRT40 FGG

4.27e-061681126d02eba7ece17edcdd47fd6b784c93910ce61090f
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYBB NCF2 ACTN1 SLCO4C1 MEGF9 SORL1

4.73e-061711126ab21f20ec041cbaacccbd7da4dccdb77ec8bc5c6
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYBB NCF2 ACTN1 SLCO4C1 MEGF9 SORL1

4.73e-06171112697ad2cfff568a9d006ab1d2e6e00946ee4e3beb3
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FOLR1 GAS6 EXTL1 PKHD1L1 PTN PAPPA

5.06e-06173112630d67738633493d47f06ae452424382f069b6c0a
ToppCellEpithelial-Epithelial-C_(AT2)|Epithelial / shred on cell class and cell subclass (v4)

NPC1 TSPAN11 SFTPD RPS8 SLCO4C1 LRP2

5.06e-061731126f57cbf5bd2a9e5db47b4919e9cd5e50781c1a990
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FOLR1 GAS6 EXTL1 PKHD1L1 PTN PAPPA

5.23e-061741126a9c6edf5c3fc119c24425f921c5566a8356c30fe
ToppCellMonocytes-IFN-activated_Monocytes|Monocytes / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

BRINP3 FN1 ITGB7 LIMS1 BAZ2A ZNF728

5.58e-0617611266a4b403ee3e4dc4f23fbd7a154011e41fd429a9e
ToppCell343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-|343B / Donor, Lineage, Cell class and subclass (all cells)

FN1 KRT34 LAMA2 LRP1B PTN LRP1

5.58e-0617611262e94bbe17c0bb65dc58b4ebc0cb829258bd7373b
ToppCell3'_v3-GI_small-bowel-Myeloid_Mac-Macrophage|GI_small-bowel / Manually curated celltypes from each tissue

CYBB FN1 NCF2 ACTN1 LDLRAD3 LRP1

5.58e-0617611264be270f6bb7da4070f972aca403109751646d155
ToppCell343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)|343B / Donor, Lineage, Cell class and subclass (all cells)

FN1 KRT34 LAMA2 LRP1B PTN LRP1

5.58e-061761126f33ab41d121b59d871ad7d48ca021524a027d2ef
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYBB NCF2 ACTN1 SLCO4C1 MEGF9 SORL1

5.77e-061771126065bebd22031f143e90a407f952b444a3f8818c7
ToppCellfacs-Marrow-Granulocytes-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYBB NCF2 ACTN1 SLCO4C1 MEGF9 SORL1

5.77e-061771126eb304f20aab075bd17aa3aef819386c0e1a235bd
ToppCellP28-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FOLR1 GAS6 EXTL1 PKHD1L1 PPP2R2B LRP2

5.96e-0617811261e05bc26591fea16e29bcfc5f538dda1dc427f05
ToppCellP28-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ADAM23 ADAM11 PTN PPP2R2B MEGF9 PAPPA

6.35e-0618011261e819c5c87704ec6535dfeaae56561895e239d07
ToppCellRA-16._Neuronal|RA / Chamber and Cluster_Paper

TSPAN11 SYT10 PPP2R2B MEGF9 SEMA3B SCN9A

6.35e-0618011265842febfdabac61ce970254fb0ef17a628f1b8c0
ToppCellPCW_10-12-Neuronal-Neuronal_postreplicative|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

TSPAN11 SYT10 CRB1 PPP2R2B SEMA3B FST

6.56e-0618111261aebb62ed4439db444ee9d30688212b86ee3d9ef
ToppCellPCW_10-12-Neuronal-Neuronal_postreplicative-neuro_NA|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

TSPAN11 SYT10 CRB1 PPP2R2B SEMA3B FST

6.56e-0618111266aee2ddee4790250ef3b2ef0038bd9839925c995
ToppCellPCW_10-12-Neuronal|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

TSPAN11 SYT10 CRB1 PPP2R2B SEMA3B FST

6.56e-061811126381b553e2cae65ce6be100662a5f9f963353840c
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADAM23 ADAM11 PTN MEGF9 SEMA3B PAPPA

6.77e-061821126a1c0e4090a9e7aa4941a40c817d178de144888b6
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FOLR1 GAS6 PKHD1L1 PTN LRP2 PAPPA

6.77e-0618211269966f42c338cbd471efa8ffc765a6ce93693aa75
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM23 ADAM11 PTN SEMA3B PAPPA FST

6.98e-0618311268330c39184ce076e1f95fd3725b68af551d89db0
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PKD1L2 LRP1B PKHD1L1 LOXHD1 SCN9A LRP2

7.20e-0618411262cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PKD1L2 LRP1B PKHD1L1 LOXHD1 SCN9A LRP2

7.20e-061841126ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PKD1L2 LRP1B PKHD1L1 LOXHD1 SCN9A LRP2

7.20e-0618411262b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellPND01-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NPC1 TSPAN11 SFTPD GAS6 SLCO4C1 LRP2

7.43e-061851126fd51fef8c69e34c72017d8371ab0a0d7be5701f2
ToppCellPND01-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NPC1 TSPAN11 SFTPD GAS6 SLCO4C1 LRP2

7.43e-061851126bea26e369ae91006052b973cd89b4c49afa9e553
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SPOCK1 SFTPD GAS6 PKHD1L1 PPP2R2C SEMA3B

7.43e-061851126492529121cb9e88bd3c0db6b54af3cd2979572bc
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

SPOCK1 LRP1B PTN NELL1 PPP2R2B PPP2R2C

7.66e-0618611268915436d09775f2828a7678af203b1082b36e21c
ToppCelldroplet-Limb_Muscle-nan-24m-Macroglial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPIRE2 ADAM23 ADAM11 PTN PPP2R2B PPP2R2C

7.66e-061861126ea936e66ae4b7b40564711fad60ac0137327995f
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SPOCK1 LAMA2 LRP1B PTN EGFR LRP1

7.66e-0618611267582b5154d8e5a4434817b5ab77a10b789ea2288
ToppCellPND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NPC1 TSPAN11 SFTPD GAS6 SLCO4C1 LRP2

7.90e-0618711266ab51e17a7782c2ae6394cad813dc3a2cde70c89
ToppCellLA-01._Fibroblast_I|World / Chamber and Cluster_Paper

FN1 SPOCK1 LAMA2 EGFR LRP1 ZFHX3

7.90e-0618711264ea486991f66c29728d127171a07b81404ec0b78
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSPAN11 LAMA2 PKHD1L1 LRP2 PAPPA FST

7.90e-0618711264e553721fa5598cb211f44e3226280b7e6885484
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSPAN11 LAMA2 PKHD1L1 LRP2 PAPPA FST

7.90e-061871126d36e7fc6125e7a4310499365022d38f34b757a73
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSPAN11 LAMA2 PKHD1L1 LRP2 PAPPA FST

7.90e-061871126827eae63fabf6892a82ce7779b5f395958d3d628
ToppCelldroplet-Limb_Muscle-nan-24m-Macroglial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPIRE2 ADAM23 ADAM11 PTN PPP2R2C SEMA3B

7.90e-061871126a0bd2b0ec9e73521c245037b1dd51ff8cf24cbf5
ToppCelldroplet-Limb_Muscle-nan-24m-Macroglial-Schwann_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPIRE2 ADAM23 ADAM11 PTN PPP2R2C SEMA3B

7.90e-061871126f2af79a20438108c814a73f9e24cd986d537237f
ToppCellPND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NPC1 TSPAN11 SFTPD GAS6 SLCO4C1 LRP2

7.90e-061871126e176b5b051690f840f3b12c8f7c4cc10cbe2bbae
ToppCellwk_08-11-Mesenchymal-Mesothelial-Early_mesothelial|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SFTPD GAS6 SYT10 PTN PPP2R2C PAPPA

8.14e-0618811266151051c027c7ff7d5d4bf5f1e11d7fe58eb22ed
ToppCellCOVID-19-Heart-Fib_1|COVID-19 / Disease (COVID-19 only), tissue and cell type

SPOCK1 LAMA2 LDLRAD3 PTN EGFR LRP1

8.14e-061881126fe361215f4ba841aa5e1e581fb56f2f4d3ccd201
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

SPOCK1 SFTPD PKHD1L1 PPP2R2C SEMA3B LRP2

8.14e-0618811269655a4c47b644a870017d349b99063e17dbae572
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CYBB GAS6 NAIP NCF2 CD209 CD163L1

8.14e-061881126cb091912f9b627a78a8793a37df7f1de839f887f
ToppCellPND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NPC1 TSPAN11 SFTPD GAS6 SLCO4C1 LRP2

8.14e-061881126562f5984efdbbcb8f53ddcee033ccbf9eb678425
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_myocytic|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

BRINP3 LAMA2 ACTN1 JAG1 ZFHX3 FST

8.39e-061891126b6d5dec55bf352f6ae19d8f488ae70aa10fb9a8f
ToppCellmoderate-Epithelial-Ionocyte|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

SPOCK1 FOLR1 GAS6 MEGF9 EGFR SCN9A

8.39e-0618911266011b747e27d61d222380a7bffdd921a68e9b657
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_myocytic|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

BRINP3 LAMA2 ACTN1 JAG1 ZFHX3 FST

8.39e-061891126f75cebd4c3e54e297557449ba67ccc8d1a2a14f5
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CAPN3 PTN SEMA3B LRP2 ZFHX3 NOTCH1

8.39e-06189112642ab4cc5fbf8580841f31889446fe4499df1a464
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-Pericytes-angiogenic_pericyte|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VLDLR FN1 ADAM23 JAG1 PAPPA ZFHX3

8.39e-061891126d0c7549be4f77520c23dddf4f94d0fcad0081e37
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SYT10 NELL1 SLCO4C1 LRP1 PAPPA NOTCH2

8.39e-06189112645e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCell(2)_Fibroblasts-(22)_Fibro-3|World / Cell class and subclass of bone marrow stroma cells in homeostatis

ADAM23 SCARF2 FOLR1 LAMA2 PTN SEMA3B

8.65e-0619011263aed03b87ba2c8d479048c3ceef3ff5e38746c28
ComputationalGenes in the cancer module 46.

CYBB FN1 SPOCK1 SFTPD GAS6 CD55 NCF2 PTN LRP1 UMOD FGG

7.30e-053947411MODULE_46
ComputationalImmune response.

CYBB FN1 SPOCK1 SFTPD GAS6 CD55 NCF2 PTN LRP1 UMOD FGG

7.99e-053987411MODULE_75
ComputationalGenes in the cancer module 236.

VLDLR LDLR SORL1

2.37e-0418743MODULE_236
ComputationalMetal / Ca ion binding.

GAS6 LDLR CRB1 NELL1 LRP1 UMOD

2.98e-04133746MODULE_324
ComputationalGenes in the cancer module 121.

SPOCK1 GAS6 PTN LRP1 FGG

5.83e-0499745MODULE_121
Drugmonatepil

SCARF2 LRP1B LDLR LRP1 LRP2 SORL1

4.81e-09291106CID000060810
Drugprobucol

NPC1 VLDLR SCARF2 LRP1B LDLR SCARF1 LRP1 LRP2 FGG SORL1

6.40e-0916211010CID000004912
Drug25-hydroxycholesterol

NPC1 SCARF2 LRP1B LDLR LRP1 LRP2 FGG NOTCH2 SORL1

8.45e-081601109CID000065094
DrugLMWH

FN1 SPOCK1 LAMA2 FNDC3A EXTL1 LDLR ADCY8 SCARF1 PTN EGFR LRP1 LRP2 PAPPA FGG FST

7.14e-0766311015CID000000772
DrugCalpain inhibitor I

CAPN12 SCARF2 CAPN3 LRP1B LDLR EGFR NFKBIB LRP1 LRP2 SORL1

1.07e-0628011010CID000004332
Drugpitavastatin

SCARF2 LRP1B LDLR PTN LRP1 LRP2 SORL1

1.36e-061141107CID005282451
Drugtroglitazone

VLDLR FN1 SCARF2 CAPN3 FNDC3A LRP1B LDLR GFPT1 SCARF1 LRP1 LRP2 FST SORL1

1.58e-0652611013CID000005591
Drugiodide

CYBB VLDLR FN1 FNDC3A TRIM24 LDLR ADCY8 SCARF1 LIMS1 EGFR LRP1 LRP2 FGG

1.87e-0653411013CID000024841
Drugepicholesterol

NPC1 VLDLR SCARF2 LRP1B LDLR GFPT1 ADCY8 SCARF1 EGFR CBFA2T2 LRP1 LRP2 FGG SORL1

2.38e-0663611014CID000000304
DrugNifuroxazide [965-52-6]; Down 200; 14.6uM; MCF7; HT_HG-U133A

BRINP3 GAS6 LDLR PTN TRIM33 SEMA3B LRP2 TBCD

3.72e-0618811084835_DN
DrugDiphenhydramine hydrochloride [147-24-0]; Up 200; 13.8uM; HL60; HT_HG-U133A

KDM5C PTN BAZ2A CBFA2T2 NFKBIB FST TBCD SOS2

5.25e-0619711081871_UP
Drugsterol

NPC1 VLDLR SCARF2 CD55 LDLR ITGB7 SCARF1 LRP1 LRP2

5.71e-062651109CID000001107
Drugezetimibe

NPC1 SCARF2 LRP1B LDLR LRP1 LRP2 SORL1

7.40e-061471107CID000150311
Drugrhamnose

FN1 SFTPD GBA2 ADCY8 CD209 EGFR JAG1 FGG POFUT2 NOTCH2

9.04e-0635611010CID000000840
DrugSuccimer

CYBB USP18 VLDLR MBTD1 FN1 CAPN3 GAS6 NAIP LDLRAD3 ITGB7 CD209 LIMS1 NLRP10 EGFR CBFA2T2 JAG1 LRP1 PAPPA SORL1

9.43e-06126411019ctd:D004113
DrugVerteporfin [129497-78-5]; Down 200; 2.8uM; HL60; HT_HG-U133A

CYBB FN1 KDM5C LDLR NOTCH1 NOTCH2 SORL1

1.29e-0516011076133_DN
DrugMagnetite Nanoparticles

CYBB USP18 VLDLR MBTD1 FN1 CAPN3 GAS6 NAIP LDLRAD3 ITGB7 CD209 LIMS1 NLRP10 EGFR CBFA2T2 JAG1 LRP1 PAPPA SORL1

1.56e-05131011019ctd:D058185
DrugN-acetylhexosamine

CYBB FN1 SFTPD GAS6 NAIP LDLR ITGB7 GFPT1 CD209 EGFR FGG

1.82e-0547211011CID000000899
DrugArg-tyr-asp

FN1 FNDC3A FGG

2.34e-05121103CID000131136
Drugsodium cholate

NPC1 SCARF2 KRT34 GBA2 LRP1B LDLR JAG1 LRP1 LRP2 SORL1

2.92e-0540811010CID000000303
DrugDesipramine hydrochloride [58-28-6]; Up 200; 13.2uM; MCF7; HT_HG-U133A

FOLR1 FNDC3A LDLR GFPT1 MEGF9 SEMA3B POFUT2

2.96e-0518211075292_UP
Drug17-AAG; Up 200; 1uM; MCF7; HT_HG-U133A_EA

VLDLR GAS6 ZNF227 LDLR GFPT1 BAZ2A JAG1

2.96e-051821107998_UP
Drug17-AAG; Up 200; 1uM; MCF7; HT_HG-U133A_EA

VLDLR ZNF337 FOLR1 FNDC3A ZNF227 BAZ2A JAG1

3.28e-051851107831_UP
DrugTrifluridine [70-00-8]; Down 200; 13.6uM; HL60; HT_HG-U133A

ZNF337 UBE2O BAZ2A NFKBIB ZNF345 SOS1 SOS2

4.02e-0519111076136_DN
Drug3-alpha-Hydroxy-5-beta-androstan-17-one [53-42-9]; Down 200; 13.8uM; PC3; HT_HG-U133A

KDM5C ZNF227 LDLR EGFR BAZ2A SEMA3B LRP2

4.02e-0519111074298_DN
DrugEpi Lovastatin

VLDLR SCARF2 LRP1B LDLR SCARF1 LRP1 LRP2 FGG SORL1

4.20e-053411109CID000003962
DrugHarmaline hydrochloride dihydrate [6027-98-1]; Up 200; 14uM; PC3; HT_HG-U133A

FN1 LAMA2 PTN NFKBIB SCN9A LRP2 SOS2

4.30e-0519311076623_UP
DrugOxybutynin chloride [1508-65-2]; Down 200; 10.2uM; MCF7; HT_HG-U133A

MBTD1 ZNF337 KDM5C FNDC3A JAG1 NFKBIB SOS2

4.44e-0519411073168_DN
DrugDapsone [80-08-0]; Up 200; 16.2uM; HL60; HT_HG-U133A

ADAM23 KDM5C LDLR BAZ2A CBFA2T2 NFKBIB SOS2

4.44e-0519411071868_UP
DrugPF-00875133-00 [351322-64-0]; Down 200; 10uM; MCF7; HT_HG-U133A

MBTD1 ZNF227 LDLR EGFR CBFA2T2 PAPPA SOS1

4.59e-0519511075967_DN
DrugDiltiazem hydrochloride [33286-22-5]; Down 200; 8.8uM; MCF7; HT_HG-U133A

MBTD1 GAS6 XAB2 EGFR CBFA2T2 JAG1 NFKBIB

4.59e-0519511071532_DN
DrugFluorometholone [426-13-1]; Up 200; 10.6uM; PC3; HT_HG-U133A

ADAM23 FOLR1 ITGB7 CRB1 CBFA2T2 NFKBIB LRP1

4.74e-0519611075771_UP
Drugalpha-estradiol; Up 200; 0.01uM; HL60; HT_HG-U133A

CAPN3 GAS6 LAMA2 ITGB7 NFKBIB LRP2 NOTCH2

4.74e-0519611071151_UP
DrugAmikacin hydrate [37517-28-5]; Up 200; 6.6uM; PC3; HT_HG-U133A

VLDLR FN1 ITGB7 BAZ2A SCN9A LRP2 NOTCH2

4.74e-0519611076715_UP
DrugD-cycloserine [68-41-7]; Down 200; 39.2uM; MCF7; HT_HG-U133A

IFT22 KDM5C BAZ2A NFKBIB POFUT2 NOTCH2 SOS2

4.74e-0519611076782_DN
DrugNifurthiazole

FN1 FNDC3A FST

4.79e-05151103CID003607071
DrugDomperidone maleate; Down 200; 7.4uM; PC3; HT_HG-U133A

MBTD1 CD209 MEGF9 CBFA2T2 NFKBIB LRP1 FGG

4.90e-0519711074640_DN
DrugHarmaline hydrochloride dihydrate [6027-98-1]; Down 200; 14uM; MCF7; HT_HG-U133A

KDM5C ZNF227 ZNF248 BAZ2A NFKBIB TBCD SOS2

4.90e-0519711074968_DN
DrugPilocarpine nitrate [148-72-1]; Down 200; 14.8uM; PC3; HT_HG-U133A

ADAM23 ITGB7 PTN TRIM33 CBFA2T2 NFKBIB NOTCH2

4.90e-0519711076741_DN
DrugPicotamide monohydrate [80530-63-8]; Down 200; 10.2uM; MCF7; HT_HG-U133A

FN1 KDM5C JAG1 NFKBIB SEMA3B ZFHX3 NOTCH2

4.90e-0519711076787_DN
DrugClomipramine hydrochloride [17321-77-6]; Down 200; 11.4uM; MCF7; HT_HG-U133A

MBTD1 ZNF337 ZNF227 BAZ2A NFKBIB TBCD SOS2

4.90e-0519711073182_DN
DrugDiperodon hydrochloride [537-12-2]; Down 200; 9.2uM; PC3; HT_HG-U133A

FN1 EGFR BAZ2A NFKBIB SCN9A LRP1 TBCD

5.05e-0519811074498_DN
DrugDoxylamine succinate [562-10-7]; Up 200; 10.2uM; PC3; HT_HG-U133A

CYBB LAMA2 PTN NFKBIB LRP2 POFUT2 ZNF345

5.05e-0519811074235_UP
Drug17alpha-estradiol

VLDLR FN1 SCARF2 FNDC3A LRP1B LDLR GFPT1 ADCY8 SCARF1 PPP2R2C EGFR JAG1 LRP1 LRP2 PAPPA FGG FST SORL1

5.08e-05130311018CID000000450
DrugH2O2

CYBB FN1 PPP2R2D SCARF2 GAS6 FNDC3A NCF2 TXNDC17 LDLR ADCY8 SCARF1 PPP2R2B PPP2R2C EGFR NFKBIB FGG FST

5.19e-05118311017CID000000784
DrugNorfloxacin [70458-96-7]; Up 200; 12.6uM; HL60; HG-U133A

FN1 CAPN3 LDLR ZNF248 BAZ2A CBFA2T2 SOS1

5.22e-0519911071406_UP
DrugCiprofibrate [52214-84-3]; Down 200; 13.8uM; PC3; HT_HG-U133A

KDM5C BAZ2A NFKBIB SCN9A LRP2 ZFHX3 TBCD

5.22e-0519911075740_DN
DrugGuanabenz acetate [23256-50-0]; Down 200; 13.8uM; HL60; HG-U133A

FN1 ZNF337 CAPN3 PTN BAZ2A SOS1 SOS2

5.22e-0519911072045_DN
DrugFlucytosine [2022-85-7]; Up 200; 31uM; MCF7; HT_HG-U133A

FN1 ZNF227 JAG1 SCN9A LRP2 FST NOTCH2

5.39e-0520011076450_UP
DrugU-320

FN1 FNDC3A

6.92e-0531102CID000077162
Drugdibenzyl-N,N-diethylphosphoramidite

FN1 TRIM24 TRIM33 PPP2R2B SORL1

7.22e-05891105CID005066231
DrugAC1L9LHO

GBA2 CD209 CBFA2T2 NOTCH2

7.84e-05471104CID000448003
DrugBiomer

FN1 FNDC3A FGG

8.49e-05181103CID003085227
DrugAC1L4UUJ

DLL1 LDLR FST

8.49e-05181103CID000164475
Drugmangrove

NPC1 ACSL6 SCARF2 DLL1 LRP1B LDLR ADCY8 LRP1 LRP2 SORL1

9.17e-0546811010CID000000965
DrugAC1L1GUQ

DLL1 LDLR JAG1 NOTCH2

1.00e-04501104CID000003849
Drugsimvastatin

FN1 SCARF2 FNDC3A LRP1B LDLR LRP1 LRP2 FGG SORL1

1.17e-043901109CID000054454
Drugisocycloheximide

NPC1 USP18 FN1 SCARF2 LAMA2 FNDC3A LRP1B LDLR ADCY8 EGFR NFKBIB LRP1 LRP2 SORL1

1.18e-0490511014CID000002900
Drugdelta-(l-alpha-aminoadipoyl)-l-cysteinyl-glycine

FN1 SCARF2 FNDC3A ADCY8 SCARF1 PAPPA FST

1.26e-042291107CID004369448
Drug8-Bromo Cyclic Adenosine Monophosphate

VLDLR ZNF486 FN1 KRT34 NCF2 TRIM24 LDLR SLCO4C1 EGFR JAG1 PAPPA ZNF454

1.33e-0469311012ctd:D015124
DrugLidocaine

EGFR SCN9A

1.38e-0441102DB00281
DrugSF-6,5

FN1 FNDC3A

1.38e-0441102CID000126860
DrugAC1L1J6H

SCARF2 LRP1B LDLR LRP1 LRP2 FGG SORL1

1.51e-042361107CID000004889
Drugprochlorperazine dimaleate salt; Up 200; 10uM; MCF7; HT_HG-U133A_EA

NPC1 CD55 FNDC3A LDLR POFUT2 SOS2

1.57e-0416611061053_UP
DrugPVLA

NPC1 FN1 FNDC3A

1.58e-04221103CID000126094
DrugNiclosamide [50-65-7]; Up 200; 12.2uM; PC3; HT_HG-U133A

NPC1 CD55 LDLR GFPT1 EGFR SOS2

1.68e-0416811064018_UP
DrugRges Peptide

FN1 FNDC3A FGG

1.81e-04231103CID000121927
DrugCycloheximide [66-81-9]; Down 200; 14.2uM; HL60; HT_HG-U133A

FN1 ZNF337 ADAM23 GAS6 LDLR NOTCH2

1.85e-0417111062723_DN
Druggeldanamycin; Up 200; 1uM; MCF7; HT_HG-U133A_EA

VLDLR FNDC3A ZNF227 LDLR GFPT1 JAG1

2.03e-041741106864_UP
Druggeldanamycin; Up 200; 1uM; MCF7; HT_HG-U133A_EA

VLDLR ZNF227 LDLR GFPT1 JAG1 ZFHX3

2.03e-041741106972_UP
DrugTTEGDA

FN1 SOS1

2.29e-0451102CID000028803
Drug17-AAG; Up 200; 1uM; MCF7; HT_HG-U133A_EA

VLDLR FNDC3A ZNF227 BAZ2A JAG1 SEMA3B

2.29e-041781106916_UP
DrugAC1L320U

FN1 PPP2R2D PPP2R2C

2.34e-04251103CID000133020
DrugC12063

FN1 SFTPD CAPN3 CD55 FNDC3A LDLR EGFR FGG SORL1

2.39e-044291109CID005282055
Druggeldanamycin; Up 200; 1uM; MCF7; HT_HG-U133A

VLDLR MBTD1 ZNF227 LDLR GFPT1 CD209

2.66e-0418311066946_UP
DrugApigenin [520-36-5]; Down 200; 14.8uM; HL60; HT_HG-U133A

RANBP2 GNPTAB NCF2 ZNF248 JAG1 NOTCH1

2.74e-0418411061321_DN
Drugsodium chloride

FN1 SPOCK1 SFTPD GNPTAB CAPN3 FNDC3A GBA2 CD209 EGFR UMOD FGG POFUT2 SLC37A4

2.78e-0486511013CID000000206
DrugCd-B

FN1 FNDC3A ITGB7 TBCD

2.78e-04651104CID000447221
Drugprochlorperazine dimaleate salt; Up 200; 10uM; PC3; HT_HG-U133A

NPC1 MBTD1 ADAM23 CD55 PTN POFUT2

2.82e-0418511061215_UP
Drugvitamin E

VLDLR SCARF2 LRP1B LDLR SCARF1 PPP2R2B LRP1 LRP2 SORL1

2.92e-044411109CID000002116
DrugChlorpromazine hydrochloride [69-09-0]; Up 200; 11.2uM; MCF7; HT_HG-U133A

IFT22 GAS6 FNDC3A LDLR LRP2 SOS2

3.17e-0418911061700_UP
DrugCycloheximide

ACSL6 VLDLR LDLR PTN EGFR LRP2 PAPPA FST SOS1

3.17e-044461109ctd:D003513
Drugcanola oil

VLDLR ACTN1 DLL1 LDLR LIMS1

3.18e-041221105ctd:C061996
DrugDexamethasone acetate [1177-87-3]; Up 200; 9.2uM; HL60; HG-U133A

FN1 SPOCK1 ADAM23 CAPN3 BAZ2A TBCD

3.26e-0419011061396_UP
Drugoxaprozin; Up 200; 300uM; MCF7; HT_HG-U133A_EA

MBTD1 CD55 FNDC3A ADAM11 ZNF227 CBFA2T2

3.26e-041901106863_UP
DrugF 155

FN1 FNDC3A

3.43e-0461102CID003028671
DrugF 29

FN1 FNDC3A

3.43e-0461102CID006419426
Drugethylene acrylic acid

FN1 FNDC3A

3.43e-0461102CID000062701
Drugconduritol aziridine

CAPN3 GBA2

3.43e-0461102CID000130051
DrugAC1NSXES

CAPN3 GBA2

3.43e-0461102CID005318890
DrugDeptropine citrate [2169-75-7]; Up 200; 7.6uM; PC3; HT_HG-U133A

BRINP3 CAPN3 ADAM11 SCN9A LRP1 FST

3.44e-0419211065118_UP
DrugClemastine fumarate [14976-57-9]; Up 200; 8.6uM; MCF7; HT_HG-U133A

LDLR PTN PPP2R2B SEMA3B FST POFUT2

3.44e-0419211067485_UP
DrugMesalamine [89-57-6]; Down 200; 26.2uM; HL60; HT_HG-U133A

FN1 CAPN3 ZNF248 MEGF9 ZNF345 SOS2

3.44e-0419211066162_DN
DrugMiconazole [22916-47-8]; Up 200; 9.6uM; PC3; HG-U133A

CD55 PPP2R2B JAG1 LRP1 NOTCH1 TBCD

3.54e-0419311061896_UP
DrugHaloperidol [52-86-8]; Down 200; 10.6uM; MCF7; HT_HG-U133A

MBTD1 PPP2R2B EGFR CBFA2T2 LRP2 SOS2

3.54e-0419311065273_DN
DrugThiamine hydrochloride [67-03-8]; Down 200; 11.8uM; MCF7; HT_HG-U133A

VLDLR MBTD1 KDM5C NFKBIB SEMA3B POFUT2

3.54e-0419311062894_DN
DrugDehydroisoandosterone 3-acetate [853-23-6]; Up 200; 12.2uM; PC3; HT_HG-U133A

FN1 CAPN3 ADAM11 PPP2R2B EGFR CBFA2T2

3.64e-0419411066673_UP
DrugSulfamethazine sodium salt [1981-58-4]; Up 200; 13.4uM; MCF7; HT_HG-U133A

VLDLR MBTD1 LDLR BAZ2A NFKBIB LRP2

3.64e-0419411063422_UP
DrugBenzethonium chloride [121-54-0]; Down 200; 9uM; MCF7; HT_HG-U133A

FOLR1 GNPTAB GAS6 XAB2 NFKBIB TBCD

3.64e-0419411066070_DN
DrugBacampicillin hydrochloride [37661-08-8]; Down 200; 8uM; MCF7; HT_HG-U133A

FN1 GAS6 FNDC3A CBFA2T2 NFKBIB POFUT2

3.64e-0419411064417_DN
DiseaseGlioblastoma Multiforme

FN1 TRIM33 EGFR JAG1 NOTCH1 NOTCH2

3.11e-061111066C1621958
DiseaseAlzheimer's disease (is_implicated_in)

VLDLR NCF2 LDLR PPP2R2B LRP1 SORL1

8.46e-061321066DOID:10652 (is_implicated_in)
Diseaseautosomal dominant cerebellar ataxia (implicated_via_orthology)

PPP2R2D PPP2R2B PPP2R2C

9.68e-06121063DOID:1441 (implicated_via_orthology)
DiseaseGlioblastoma

FN1 EGFR JAG1 NOTCH1 NOTCH2

9.93e-06791065C0017636
DiseaseHepatic ductular hypoplasia

JAG1 NOTCH2

1.28e-0521062C2930797
DiseaseAlagille syndrome (is_implicated_in)

JAG1 NOTCH2

1.28e-0521062DOID:9245 (is_implicated_in)
DiseaseAlagille Syndrome 2

JAG1 NOTCH2

1.28e-0521062C1857761
DiseaseAlagille Syndrome 1

JAG1 NOTCH2

1.28e-0521062C1956125
DiseaseAlagille Syndrome

JAG1 NOTCH2

1.28e-0521062C0085280
DiseaseArteriohepatic dysplasia

JAG1 NOTCH2

1.28e-0521062cv:C0085280
DiseaseGiant Cell Glioblastoma

FN1 EGFR JAG1 NOTCH1 NOTCH2

1.34e-05841065C0334588
Diseasecorpus callosum volume measurement

DLL1 NELL1 EGFR JAG1 SOS1

3.12e-051001065EFO_0010299
Diseasefour-jointed box protein 1 measurement

GNPTAB LDLRAD3

3.83e-0531062EFO_0801605
Diseasecorpus collosum mid-posterior volume measurement

VLDLR EGFR JAG1

9.78e-05251063EFO_0010300
Diseasecystatin C measurement

SPIRE2 ZNF337 FNDC3A CRB1 LRP1 LRP2 UMOD SOS1

1.04e-044021068EFO_0004617
DiseaseChronic granulomatous disease

CYBB NCF2

1.27e-0451062cv:C0018203
Diseaseintestinal cancer (implicated_via_orthology)

EGFR NOTCH1 NOTCH2

2.07e-04321063DOID:10155 (implicated_via_orthology)
DiseaseSquamous cell carcinoma of lung

TRIM24 EGFR NOTCH1

2.07e-04321063C0149782
Diseasecervical cancer

EGFR NOTCH1 NOTCH2

2.49e-04341063C4048328
Diseasetemporal arteritis (is_marker_for)

DLL1 JAG1

2.65e-0471062DOID:13375 (is_marker_for)
Diseaseadenocarcinoma (implicated_via_orthology)

NOTCH1 NOTCH2

2.65e-0471062DOID:299 (implicated_via_orthology)
Diseasecentral nervous system cancer (implicated_via_orthology)

NOTCH1 NOTCH2

2.65e-0471062DOID:3620 (implicated_via_orthology)
DiseaseUterine Cervical Neoplasm

EGFR NOTCH1 NOTCH2

2.71e-04351063C0007873
Diseasecervical cancer (is_marker_for)

CD55 ZFHX3 SOS1

2.95e-04361063DOID:4362 (is_marker_for)
DiseaseScoliosis, unspecified

DLL1 NOTCH1

3.53e-0481062C0036439
DiseaseSquamous cell carcinoma of esophagus

TXNDC17 EGFR NOTCH1 NOTCH2

3.90e-04951064C0279626
Diseaseobsolete aging

TSPAN11 CAPN3 MYO18A LRP1B ZNF248 ZFHX3

5.24e-042791066GO_0007568
Diseasewhite matter microstructure measurement

CAPN12 SPIRE2 CRB1 EGFR JAG1 LRP2 SOS1

5.30e-043901067EFO_0005674
Diseaseurinary 6‑hydroxymelatonin sulfate to creatinine ratio

LDLRAD3 ZFHX3

5.65e-04101062EFO_0021488
Diseaseresponse to angiotensin-converting enzyme inhibitor, Cough

SPOCK1 FNDC3A PKD1L2

6.11e-04461063EFO_0005325, HP_0012735
DiseaseMammary Carcinoma, Human

FN1 RPS8 DLL1 EGFR JAG1 FST NOTCH1 NOTCH2

6.25e-045251068C4704874
DiseaseMammary Neoplasms, Human

FN1 RPS8 DLL1 EGFR JAG1 FST NOTCH1 NOTCH2

6.25e-045251068C1257931
DiseaseMammary Neoplasms

FN1 RPS8 DLL1 EGFR JAG1 FST NOTCH1 NOTCH2

6.41e-045271068C1458155
Diseasesystemic lupus erythematosus (is_marker_for)

SFTPD LDLR PPP2R2B

6.51e-04471063DOID:9074 (is_marker_for)
Diseasepolybrominated biphenyl measurement, gestational serum measurement, fetal genotype effect measurement, polybrominated diphenyl ether measurement

LOXHD1 ZFHX3

6.88e-04111062EFO_0007959, EFO_0007961, EFO_0007962, EFO_0007964
DiseaseCongenital Abnormality

FOLR1 NOTCH1

6.88e-04111062C0000768
DiseaseBreast Carcinoma

FN1 RPS8 DLL1 EGFR JAG1 FST NOTCH1 NOTCH2

7.33e-045381068C0678222
Diseaselung adenocarcinoma (is_implicated_in)

LRP1B EGFR ZFHX3

7.36e-04491063DOID:3910 (is_implicated_in)
Diseasepulmonary fibrosis (biomarker_via_orthology)

EGFR JAG1 NOTCH1

7.81e-04501063DOID:3770 (biomarker_via_orthology)
Diseasebrain disease (is_implicated_in)

RANBP2 PPP2R2B

8.24e-04121062DOID:936 (is_implicated_in)
DiseaseObesity

NPC1 VLDLR LDLR GFPT1 ZFHX3

8.85e-042051065C0028754
DiseaseNeoplasm of uncertain or unknown behavior of bladder

NOTCH1 NOTCH2

1.30e-03151062C0496930
DiseaseBenign neoplasm of bladder

NOTCH1 NOTCH2

1.30e-03151062C0154017
DiseaseCarcinoma in situ of bladder

NOTCH1 NOTCH2

1.30e-03151062C0154091
Diseasediet measurement

BRINP3 PPP2R2D ADAM23 LAMA2 LRP1B SYT10 LDLR NELL1 ZFHX3 ZNF345 SORL1

1.39e-03104910611EFO_0008111
DiseaseSynostotic Posterior Plagiocephaly

NELL1 WDR35

1.48e-03161062C1833340
DiseaseCraniosynostosis, Type 1

NELL1 WDR35

1.48e-03161062C4551902
DiseaseAcrocephaly

NELL1 WDR35

1.48e-03161062C0030044
DiseaseTrigonocephaly

NELL1 WDR35

1.48e-03161062C0265535
DiseaseScaphycephaly

NELL1 WDR35

1.48e-03161062C0265534
DiseaseSynostotic Anterior Plagiocephaly

NELL1 WDR35

1.48e-03161062C2931150
DiseaseMetopic synostosis

NELL1 WDR35

1.48e-03161062C1860819
Diseaselung non-small cell carcinoma (is_implicated_in)

SFTPD LRP1B EGFR ZFHX3

1.62e-031391064DOID:3908 (is_implicated_in)
DiseaseBladder Neoplasm

LAMA2 EGFR NOTCH1 NOTCH2

1.66e-031401064C0005695
DiseaseMalignant neoplasm of breast

FN1 SCARF2 RPS8 LAMA2 DLL1 EGFR JAG1 FST NOTCH1 NOTCH2 SORL1

1.68e-03107410611C0006142
Diseasemuscular dystrophy (is_implicated_in)

CAPN3 LAMA2

1.68e-03171062DOID:9884 (is_implicated_in)
DiseaseBrachycephaly

NELL1 WDR35

1.68e-03171062C0221356
DiseaseMalignant neoplasm of urinary bladder

LAMA2 EGFR NOTCH1 NOTCH2

1.70e-031411064C0005684
DiseaseAlcohol abuse

FN1 LDLR EGFR

1.83e-03671063C0085762
Diseasetype 1 diabetes mellitus

LRP1B NELL1 UMOD ZPBP2 NOTCH2

1.84e-032421065MONDO_0005147
DiseaseCarcinoma of bladder

NOTCH1 NOTCH2

1.88e-03181062C0699885
Diseasemaximum cigarettes per day measurement

ADCY8 EGFR

1.88e-03181062EFO_0009264
Diseasebody fat percentage

NPC1 GGNBP2 GFPT1 ADCY8 LRP1 ZFHX3 SLC37A4

1.94e-034881067EFO_0007800
Diseaseaspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement

NPC1 GGNBP2 ADCY8 LRP1 ZFHX3 SLC37A4

2.05e-033641066EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Diseaseanorexia nervosa

CRB1 TRIM33 LRP2

2.07e-03701063MONDO_0005351
DiseaseNoonan-Like Syndrome With Loose Anagen Hair

SOS1 SOS2

2.10e-03191062C3501846
DiseaseNoonan syndrome-like disorder with loose anagen hair

SOS1 SOS2

2.10e-03191062C1843181
Diseasecerebral infarction (is_marker_for)

BRINP3 SOS1

2.10e-03191062DOID:3526 (is_marker_for)
DiseaseCardio-facio-cutaneous syndrome

SOS1 SOS2

2.10e-03191062C1275081
DiseaseCostello syndrome (disorder)

SOS1 SOS2

2.10e-03191062C0587248
DiseaseCraniosynostosis

NELL1 WDR35

2.33e-03201062C0010278
DiseaseCraniofacial Abnormalities

FOLR1 EGFR LRP2 NOTCH1

2.46e-031561064C0376634
Diseaseintellectual disability (implicated_via_orthology)

KDM5C CAPN3 NSUN2

2.52e-03751063DOID:1059 (implicated_via_orthology)
DiseaseLung Neoplasms

USP18 SFTPD EGFR JAG1 NOTCH2

2.73e-032651065C0024121
DiseaseMalignant neoplasm of lung

USP18 SFTPD EGFR JAG1 NOTCH2

2.77e-032661065C0242379
DiseaseLEOPARD Syndrome

SOS1 SOS2

2.82e-03221062C0175704
Diseasedilated cardiomyopathy (implicated_via_orthology)

DLL1 EGFR JAG1

3.03e-03801063DOID:12930 (implicated_via_orthology)
Diseaseclinical and behavioural ideal cardiovascular health

BRINP3 LDLR

3.08e-03231062EFO_0007654
Diseasecreatinine measurement

CAPN12 SPIRE2 LAMA2 LDLR NELL1 LRP2 UMOD ZFHX3 SORL1 SOS2

3.12e-0399510610EFO_0004518
Diseasecongenital heart disease (is_implicated_in)

JAG1 NOTCH1

3.35e-03241062DOID:1682 (is_implicated_in)
DiseaseCarcinoma, Pancreatic Ductal

JAG1 NOTCH1

3.35e-03241062C0887833
DiseaseNoonan Syndrome

SOS1 SOS2

3.35e-03241062C0028326

Protein segments in the cluster

PeptideGeneStartEntry
DIVQCFSCGGCLEKW

NAIP

311

Q13075
FSCGGCLEKWQEGDD

NAIP

316

Q13075
QQCEDKWGHLCALAD

ADCY8

1051

P40145
NSEGEFICKENDCWC

BRINP3

266

Q76B58
DCIFDKFECVWNGSD

PPP2R2B

336

Q00005
DCIFDKFECAWNGSD

PPP2R2C

336

Q9Y2T4
CQKICDQWDNLGALT

ACTN1

476

P12814
EKGNCGKDGDRWIQC

ADAM23

636

O75077
GDWFCTVCLAQQVEG

BAZ2A

1716

Q9UIF9
SGWVQCSKQDVLCGF

ADAM11

586

O75078
DCIFDKFECCWNGSD

PPP2R2D

346

Q66LE6
CAEFSGNGWNDDKCN

CD209

356

Q9NNX6
QWPQSQKDACGEEGC

C1orf94

356

Q6P1W5
WNNAAADVVCKQLGC

CD163L1

291

Q9NR16
GQWDCSACLVQNEGS

RANBP2

1481

P49792
ECTCQVGFTGKECQW

NOTCH2NLA

91

Q7Z3S9
VGFTGKECQWTDACL

NOTCH2NLA

96

Q7Z3S9
GAECKYQFQAWGECD

PTN

96

P21246
ENEGQKCELWLCGCA

GDAP1L1

251

Q96MZ0
KVWCRNNSGEEFDCA

NSUN2

586

Q08J23
GFTGKECQWTDACLS

NOTCH2NLB

136

P0DPK3
GFTGKECQWTDACLS

NOTCH2

136

Q04721
CVNGWSGDDCSENID

NOTCH2

326

Q04721
VDGSCTCKEGWQGLD

MEGF11

461

A6BM72
NCAWCEDGVFTSNEK

KRT40

76

Q6A162
AWQCDGLPDCFDKSD

LDLRAD3

46

Q86YD5
ACGWDGGDCSLNFND

NOTCH1

1471

P46531
GGDCSLNFNDPWKNC

NOTCH1

1476

P46531
KRWLCDGANDCGSNE

LRP1B

901

Q9NZR2
LNTWICDGQKDCEDG

LRP1B

2696

Q9NZR2
CLTLWCENTVGDQGF

NCF2

421

P19878
GFENDSGLDFWCNIC

MBTD1

211

Q05BQ5
NQGCANSWLADKFCD

GNPTAB

506

Q3T906
CVECWANSEENDTKG

GGNBP2

516

Q9H3C7
ESKLEQLLFWCCGDN

NLRP10

216

Q86W26
ARCISKAWVCDGDND

LRP1

1116

Q07954
NMLWCNGADDCGDGS

LRP1

2581

Q07954
HFQCDCWLSKSEGDG

LOXHD1

1776

Q8IVV2
CLKGSQWSDIEEFCN

CD55

81

P08174
CLGKAADADEWCDSG

NFKBIB

6

Q15653
EESTENCWNCGRKAS

CBFA2T2

501

O43439
LHNTTGFWCENCLEG

MEGF9

426

Q9H1U4
NLQEDNWKGCDECFC

LAMA2

506

P24043
WNFREKEGDCKGCTV

LAMA2

2316

P24043
YQNWVCDGEDDCKDN

LRP2

236

P98164
DDCGDWSDELGCNKG

LRP2

3951

P98164
EDIQCTGGKKCLWDF

FST

246

P19883
KTQCTQDGSWQEGAC

PAPPA

1396

Q13219
ECTCQVGFTGKECQW

NOTCH2NLC

91

P0DPK4
VGFTGKECQWTDACL

NOTCH2NLC

96

P0DPK4
AEGPKCGENSECKNW

NELL1

396

Q92832
CSWANVKEEVAGQCQ

PKD1L2

206

Q7Z442
CAWCKQLNFTASGEA

ITGB7

61

P26010
LCGKDADACNATNWI

NPC1

176

O15118
DKFEGNCAEQDGSGW

FGG

346

P02679
TCCTDWGQFFLIQEK

SLC37A4

241

O43826
NGSCWGAGEENCQKL

EGFR

196

P00533
DVCQGSLGNCWFLAA

CAPN12

96

Q6ZSI9
NNKGTGCEFELWDCG

IFT22

51

Q9H7X7
SDQCAGQWFLKACGL

GBA2

751

Q9HCG7
CQEGWGGLFCNQDLN

DLL1

276

O00548
GEQWQKEYLGAICSC

FN1

2396

P02751
LEWDEGKGNGEFCQC

FNDC3A

406

Q9Y2H6
AGWGGRLCDKDVNEC

GAS6

146

Q14393
WTEGLFNACGCDKQE

CYBB

361

P04839
FNACGCDKQEFQDAW

CYBB

366

P04839
SAGGDDCSLFVWKCV

EML5

1951

Q05BV3
LTSGKACEEVQWCGF

CRB1

916

P82279
ANRTDICQGELGDCW

CAPN3

116

P20807
DVGNFSWGSECCTRK

RPS8

61

P62241
NWTSGFNKCAVGAAC

FOLR1

161

P15328
QCLCETNWGGQLCDK

JAG1

281

P78504
DGVNSYKCICSDGWE

JAG1

646

P78504
VNGESFTCVCKEGWE

JAG1

761

P78504
FKQVDDLASVWCQCG

XAB2

426

Q9HCS7
PNWKRCDGHQDCQDG

SORL1

1486

Q92673
NEDWCAVCQNGGDLL

TRIM33

886

Q9UPN9
LDVDNSCDWALGVCN

TRIM43

341

Q96BQ3
EWDAENQGSFCNGCK

PSAPL1

386

Q6NUJ1
NIDGWEGKDIGQCCN

SOS2

426

Q07890
GFDGGNDKDWEANAC

GFPT1

41

Q06210
CNWFCEGSFNGSEKE

KRT34

86

O76011
GDNPWECDCNLREFK

LRTM2

196

Q8N967
FCGDQEKACEQPTHW

POFUT2

411

Q9Y2G5
WRFSCCQVNIESGKG

SCN9A

1161

Q15858
GDVVSALNKAWCVNC

LIMS1

261

P48059
GWEGKDIGQCCNEFI

SOS1

431

Q07889
NWESCFDTSKCRGDG

EXTL1

81

Q92935
SAELQCCAGWRQKDQ

SCARF1

36

Q14162
CFGTKKSQCLWENED

SPATA1

236

Q5VX52
ELNYWACKGEGEICV

ACSL6

496

Q9UKU0
EANGFCVECVEWLCK

TRIM24

171

O15164
CLWDASVQVKACAGG

UMOD

256

P07911
EKCCFWVNQSGKVQD

ERVFRD-1

436

P60508
CVEIFTNGKWNDRAC

SFTPD

351

P35247
DINDCGIKGACWIYD

SLCO4C1

646

Q6ZQN7
ECNWAGKDIGTECMN

SEMA3B

101

Q13214
NEEQAWAVCFQGCRG

SPIRE2

36

Q8WWL2
NAGWIGDRCETKCSN

SCARF2

351

Q96GP6
IAWECPEKNCAQGEG

UBE2O

366

Q9C0C9
CEECGKAFSWVSVLN

ZNF728

566

P0DKX0
STGQCWCVDKYGNEL

SPOCK1

351

Q08629
ECWLFDCGEGTQTQL

ELAC1

31

Q9H777
AKCSGDCGFTWDSNI

PKHD1L1

1051

Q86WI1
QDFKCCGSNSSADWQ

TSPAN11

151

A1L157
TELCFAGQVEWEKCS

SYT10

21

Q6XYQ8
DAGGKSWCPDCVQAE

TXNDC17

36

Q9BRA2
AVDGKWFCFNDSNIC

USP41

326

Q3LFD5
KCEECGKAFNWSSNL

ZNF208

426

O43345
KCEECGKAFNWSSNL

ZNF208

1086

O43345
KCEECGKGFGWSVNL

ZNF227

381

Q86WZ6
KCASLLEWQCGGQEI

ZNF454

121

Q8N9F8
CFSFQETDKAWHGGC

TBCD

406

Q9BTW9
LDVDNSCDWALGVCN

TRIM43B

341

A6NCK2
AVDGKWFCFNDSNIC

USP18

326

Q9UMW8
CSSFRGDWECKNQFE

ZNF345

11

Q14585
SWNKEQGFIACGGED

WDR35

21

Q9P2L0
CKECGKAFNWSSDLN

ZNF486

436

Q96H40
LGWVEQAYADKCVCG

MYO18A

41

O95411
ECGECGKTFWEKSNL

ZNF248

381

Q8NDW4
WKGACNGSVDCEDTT

ZPBP2

216

Q6X784
ICSECGQGFIWKSNL

ZNF337

601

Q9Y3M9
EDSGFICWKKGCNQV

ZFHX3

1356

Q15911
SGKNWCEEDMENGGC

VLDLR

701

P98155
GAGALQCDLCQDWFH

KDM5C

1196

P41229
SYKWVCDGSAECQDG

LDLR

41

P01130