Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainDMA

DMRTA1 DMRT3

4.74e-063242PF03474
DomainDMA

DMRTA1 DMRT3

4.74e-063242IPR005173
DomainDM

DMRTA1 DMRT3

3.31e-057242PF00751
DomainDM_2

DMRTA1 DMRT3

3.31e-057242PS50809
DomainDM_DNA-bd

DMRTA1 DMRT3

3.31e-057242IPR001275
DomainDM

DMRTA1 DMRT3

3.31e-057242SM00301
DomainDM_1

DMRTA1 DMRT3

3.31e-057242PS40000
Domain-

DMRTA1 DMRT3

3.31e-0572424.10.1040.10
DomainDMRT/dsx/mab-3

DMRTA1 DMRT3

4.41e-058242IPR026607
DomainUBA-like

DMRTA1 DMRT3

3.04e-0364242IPR009060
Pubmed

Foxg1 coordinates the switch from nonradially to radially migrating glutamatergic subtypes in the neocortex through spatiotemporal repression.

SOX5 DMRTA1 DMRT3

1.31e-071524323523356
Pubmed

Sexually dimorphic expression of multiple doublesex-related genes in the embryonic mouse gonad.

DMRTA1 DMRT3

9.56e-06724212609607
Pubmed

Vertebrate DM domain proteins bind similar DNA sequences and can heterodimerize on DNA.

DMRTA1 DMRT3

9.56e-06724217605809
Pubmed

The function of Dmrt genes in vertebrate development: it is not just about sex.

DMRTA1 DMRT3

9.56e-06724217720152
Pubmed

Novel paralogy relations among human chromosomes support a link between the phylogeny of doublesex-related genes and the evolution of sex determination.

DMRTA1 DMRT3

1.27e-05824211863363
Pubmed

Dmrt2 promotes transition of endochondral bone formation by linking Sox9 and Runx2.

DMRTA1 DMRT3

2.50e-051124233707608
Pubmed

Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice.

DMRTA1 DMRT3

4.77e-051524222932389
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

STK3 PICALM MRTFA SAMD4B MLXIP SEC16A

5.91e-05103824626673895
Pubmed

The mammalian DM domain transcription factor Dmrta2 is required for early embryonic development of the cerebral cortex.

DMRTA1 DMRT3

6.94e-051824223056351
Pubmed

Dmrt factors determine the positional information of cerebral cortical progenitors via differential suppression of homeobox genes.

DMRTA1 DMRT3

6.94e-051824231371378
Pubmed

DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169.

PICALM MOV10 SEC16A

8.08e-0512224330773093
Pubmed

Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.

KIF17 DCC

9.51e-052124225017104
Pubmed

Diverse functions of myosin VI elucidated by an isoform-specific α-helix domain.

PICALM SEC16A

1.05e-042224226950368
Pubmed

DNA sequence and analysis of human chromosome 9.

RNF38 DMRTA1 DMRT3 SEC16A

1.13e-0437024415164053
Pubmed

RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition.

STK3 MOV10 SEC16A

1.43e-0414824335676246
Pubmed

Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy.

PICALM SEC16A

1.47e-042624224067654
Pubmed

The autophagy-inducing kinases, ULK1 and ULK2, regulate axon guidance in the developing mouse forebrain via a noncanonical pathway.

DCC SEC16A

2.10e-043124229099309
Pubmed

A census of human transcription factors: function, expression and evolution.

SOX5 RAX2 DMRTA1 DMRT3 MLXIP

3.37e-0490824519274049
Pubmed

Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays.

SOX5 LMOD3

4.84e-044724235512705
Pubmed

Transcriptional analysis of Gli3 mutants identifies Wnt target genes in the developing hippocampus.

DMRTA1 DMRT3

4.84e-044724222235033
InteractionDBN1 interactions

SOX5 RNF38 STK3 PICALM MOV10 SEC16A

5.67e-06417236int:DBN1
InteractionCEP85 interactions

SOX5 MOV10 SAMD4B SEC16A

3.73e-05169234int:CEP85
DiseaseCone-Rod Dystrophy 2

RAX2 CACNA2D4

2.13e-0429222C3489532
Diseasebiological sex

SOX5 DMRTA1 DCC

6.45e-04230223PATO_0000047
Diseaseexploratory eye movement measurement

DMRTA1 DMRT3

1.66e-0381222EFO_0007700
DiseaseIschemic stroke

SOX5 PICALM MLXIP

1.73e-03324223HP_0002140
Diseasealanine measurement

DMRTA1 MLXIP

1.87e-0386222EFO_0009765
DiseaseBack pain

SOX5 DCC

1.91e-0387222HP_0003418
Diseasemultisite chronic pain

SOX5 DCC

2.27e-0395222EFO_0010100
Diseasecortical surface area measurement

SOX5 PICALM DMRTA1 MOV10 DMRT3

2.69e-031345225EFO_0010736
Diseasesevere acute respiratory syndrome, COVID-19

SOX5 NUP210 DMRT3

4.29e-03447223EFO_0000694, MONDO_0100096
Diseaseunipolar depression, bipolar disorder

SOX5 DCC

5.99e-03156222EFO_0003761, MONDO_0004985
Diseaseretinal vasculature measurement

SOX5 MRTFA DCC

6.43e-03517223EFO_0010554
Diseaseeosinophilic esophagitis

KIF17 DCC

6.52e-03163222EFO_0004232
Diseasesusceptibility to childhood ear infection measurement

STK3 NUP210

7.15e-03171222EFO_0007904
Diseaseneuroimaging measurement

SOX5 DMRTA1 DMRT3 DCC

7.44e-031069224EFO_0004346
Diseasebrain measurement, neuroimaging measurement

SOX5 DMRTA1 DCC

7.62e-03550223EFO_0004346, EFO_0004464
Diseasemean corpuscular hemoglobin concentration

SOX5 LMOD3 DMRTA1 SEC16A

8.34e-031105224EFO_0004528
DiseaseAlzheimer disease, polygenic risk score

RNF38 STK3 PICALM

9.06e-03586223EFO_0030082, MONDO_0004975
Diseasepain

SOX5 DCC

9.29e-03196222EFO_0003843
Diseasebrain volume measurement

DMRTA1 MOV10 DCC

9.44e-03595223EFO_0006930
Diseaseobsessive-compulsive disorder, attention deficit hyperactivity disorder, Tourette syndrome, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia, anorexia nervosa

SOX5 DCC

9.66e-03200222EFO_0003756, EFO_0003761, EFO_0003888, EFO_0004242, EFO_0004895, MONDO_0004985, MONDO_0005090, MONDO_0005351
Diseasepost-traumatic stress disorder

DMRTA1 DCC

9.84e-03202222EFO_0001358

Protein segments in the cluster

PeptideGeneStartEntry
LPFARPPAMSLPLEP

RAX2

106

Q96IS3
APQQIEVFPPFRLMP

NUP210

1071

Q8TEM1
PLRSFANPLLPPPMS

DCC

1341

P43146
SRMQEFFQPPPPRPP

LMOD3

441

Q0VAK6
MLSPLPQPRPSAPQV

ERN2

761

Q76MJ5
FFPPQMTLLPLPPQR

KCNRG

156

Q8N5I3
MLIPFSNPRVLPGPF

NLRP2

191

Q9NX02
PLSVPQPFLPVFTMP

MLXIP

421

Q9HAP2
PFPQPPRYPLMLRNT

DMRT3

361

Q9NQL9
LPNPRPTMPATPNFL

CACNA2D4

11

Q7Z3S7
MQVPPAFLRPPSLFL

DMRTA1

41

Q5VZB9
PTQAPEMPQPRPFRL

KIF17

991

Q9P2E2
IMYNPSANLPPPTRP

FUT5

126

Q11128
PSLLPYVLSMLPVPP

RNF38

386

Q9H0F5
PMLFPVAPRDVPLLP

MOV10

471

Q9HCE1
RPPIFNPFLTMPLPF

PRR32

251

B1ATL7
NPFLTMPLPFAPPPI

PRR32

256

B1ATL7
REMLFLAEQPPLPPP

MRTFA

171

Q969V6
PTLIYSQPVMRPPNP

PICALM

626

Q13492
FMIPTNPPPTFRKPE

STK3

231

Q13188
PLASPARVPMFPVPL

SEC16A

1961

O15027
RTQRQFPMPPRALPP

SAMD4B

571

Q5PRF9
SPMSYFRKLPQPPQP

TIGD1

546

Q96MW7
LLPTLSAPMPFPLPV

USP30

411

Q70CQ3
PPLMIPVFPPDQRTL

SOX5

276

P35711