Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
HumanPheno	Abnormal circulating creatinine concentration	C3 DBH NT5E FAN1	4.11e-05	58	18	4	HP:0012100
HumanPheno	Increased blood urea nitrogen	C3 DBH FAN1	6.28e-05	23	18	3	HP:0003138
HumanPheno	Ectopic ossification	ACVR1 NT5E	7.05e-05	4	18	2	HP:0011986
HumanPheno	Abnormal blood urea nitrogen concentration	C3 DBH FAN1	8.12e-05	25	18	3	HP:0031970
MousePheno	decreased hepatocyte proliferation	FAH C3 HIF1A	4.60e-05	29	34	3	MP:0004001
MousePheno	abnormal liver regeneration	FAH C3 HIF1A	4.60e-05	29	34	3	MP:0002658
Domain	zf-C2H2	ZBTB40 ZNF727 ZNF280D ZNF700 ZNF658 ZNF692 PATZ1	1.25e-03	693	45	7	PF00096
Domain	ZINC_FINGER_C2H2_2	ZBTB40 ZNF727 ZNF280D ZNF700 ZNF658 ZNF692 PATZ1	2.36e-03	775	45	7	PS50157
Domain	ZINC_FINGER_C2H2_1	ZBTB40 ZNF727 ZNF280D ZNF700 ZNF658 ZNF692 PATZ1	2.40e-03	777	45	7	PS00028
Domain	Znf_C2H2-like	ZBTB40 ZNF727 ZNF280D ZNF700 ZNF658 ZNF692 PATZ1	2.74e-03	796	45	7	IPR015880
Domain	Cadherin	KIAA0319 PCDHB10 PCDHB9	2.88e-03	118	45	3	IPR002126
Domain	Znf_C2H2	ZBTB40 ZNF727 ZNF280D ZNF700 ZNF658 ZNF692 PATZ1	2.92e-03	805	45	7	IPR007087
Domain	ZnF_C2H2	ZBTB40 ZNF727 ZNF280D ZNF700 ZNF658 ZNF692 PATZ1	2.98e-03	808	45	7	SM00355
Domain	BTB	ZBTB40 PATZ1 KLHL15	3.86e-03	131	45	3	PF00651
Domain	Cadherin_C	PCDHB10 PCDHB9	4.60e-03	42	45	2	IPR032455
Domain	Cadherin_C_2	PCDHB10 PCDHB9	4.60e-03	42	45	2	PF16492
Domain	-	ZBTB40 ZNF727 ZNF700 ZNF658 ZNF692 PATZ1	5.50e-03	679	45	6	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZBTB40 ZNF727 ZNF700 ZNF658 ZNF692 PATZ1	6.11e-03	694	45	6	IPR013087
Domain	BTB	ZBTB40 PATZ1 KLHL15	6.73e-03	160	45	3	PS50097
Domain	zf-C2H2_6	ZNF727 ZNF700 ZNF658 PATZ1	6.79e-03	314	45	4	PF13912
Pubmed	c-Abl tyrosine kinase plays a critical role in β2 integrin-dependent neutrophil migration by regulating Vav1 activity.	ABL1 VAV1	1.71e-06	2	46	2	23325923
Pubmed	HIF-1α and CD73 expression in cardiac leukocytes correlates with the severity of myocarditis in end-stage Chagas disease patients.	HIF1A NT5E	1.71e-06	2	46	2	32450615
Pubmed	Expression and clinical significance of CD73 and hypoxia-inducible factor-1α in gastric carcinoma.	HIF1A NT5E	1.71e-06	2	46	2	23569336
Pubmed	Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73.	HIF1A NT5E	1.71e-06	2	46	2	34650224
Pubmed	Evaluation of CD39, CD73, HIF-1α, and their related miRNAs expression in decidua of preeclampsia cases compared to healthy pregnant women.	HIF1A NT5E	5.13e-06	3	46	2	36048381
Pubmed	Vav1-dependent Rac1 activation mediates hypoxia-induced gemcitabine resistance in pancreatic ductal adenocarcinoma cells through upregulation of HIF-1α expression.	HIF1A VAV1	5.13e-06	3	46	2	37545183
Pubmed	Protective role of hypoxia-inducible factor-1α-dependent CD39 and CD73 in fulminant acute liver failure.	HIF1A NT5E	5.13e-06	3	46	2	27899277
Pubmed	c-Abl kinase is required for beta 2 integrin-mediated neutrophil adhesion.	ABL1 VAV1	1.03e-05	4	46	2	19234221
Pubmed	Thyroid hormone induces hypoxia-inducible factor 1alpha gene expression through thyroid hormone receptor beta/retinoid x receptor alpha-dependent activation of hepatic leukemia factor.	HIF1A THRB	1.03e-05	4	46	2	18239067
Pubmed	Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndrome.	DBH ABL1	1.03e-05	4	46	2	9590288
Pubmed	Association of Bcr-Abl with the proto-oncogene Vav is implicated in activation of the Rac-1 pathway.	ABL1 VAV1	1.03e-05	4	46	2	11790798
Pubmed	The HOX-5 and surfeit gene clusters are linked in the proximal portion of mouse chromosome 2.	ABL1 RPL7A	1.71e-05	5	46	2	1971250
Pubmed	A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication.	MCM5 HIF1A	1.71e-05	5	46	2	23405012
Pubmed	Isolation of complement-fragment-iC3b-binding proteins by affinity chromatography. The identification of p150,95 as an iC3b-binding protein.	C3 ABL1	1.71e-05	5	46	2	4062888
Pubmed	HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport.	HIF1A RHOT1	2.56e-05	6	46	2	19528298
Pubmed	ABL kinases regulate the stabilization of HIF-1α and MYC through CPSF1.	HIF1A ABL1	2.56e-05	6	46	2	37040401
Pubmed	Insulin signaling establishes a developmental trajectory of adipose regulatory T cells.	HIF1A NT5E	2.56e-05	6	46	2	34429546
Pubmed	Cloning, expression and genetic mapping of the mouse SH3 domain protein, SH3D2B.	C3 VAV1	2.56e-05	6	46	2	9434950
Pubmed	Identification and characterization of a seven transmembrane hormone receptor using differential display.	C3 VAV1	2.56e-05	6	46	2	9169125
Pubmed	Comparative mapping of mouse chromosome 2 and human chromosome 9q: the genes for gelsolin and dopamine beta-hydroxylase map to mouse chromosome 2.	DBH ABL1	3.58e-05	7	46	2	1315305
Pubmed	Inhibitory receptor signaling via tyrosine phosphorylation of the adaptor Crk.	ABL1 VAV1	3.58e-05	7	46	2	18835194
Pubmed	Locations of human and mouse genes encoding the RFX1 and RFX2 transcription factor proteins.	C3 VAV1	6.12e-05	9	46	2	8661125
Pubmed	Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".	C3 HIF1A ADAM8 NT5E	8.02e-05	172	46	4	20628624
Pubmed	Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells.	ABL1 VAV1	9.34e-05	11	46	2	20598684
Pubmed	Protocadherins.	PCDHB10 PCDHB9	1.32e-04	13	46	2	12231349
Pubmed	Genetic linkage analysis of the Ak1, Col5a1, Epb7.2, Fpgs, Grp78, Pbx3, and Notch1 genes in the region of mouse chromosome 2 homologous to human chromosome 9q.	DBH ABL1	1.54e-04	14	46	2	8088777
Pubmed	Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300.	ACVR1 THRB	1.78e-04	15	46	2	9267036
Pubmed	Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury.	HIF1A NT5E	3.20e-04	20	46	2	21270129
Pubmed	The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number.	PCDHB10 PCDHB9	3.20e-04	20	46	2	11322959
Pubmed	Genetic variation within the hypothalamus-pituitary-ovarian axis in women with recurrent miscarriage.	ACVR1 THRB	3.20e-04	20	46	2	20716560
Pubmed	Chromosomal localization of the proteasome Z subunit gene reveals an ancient chromosomal duplication involving the major histocompatibility complex.	DBH ABL1	4.25e-04	23	46	2	8799160
Pubmed	Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1.	ABL1 VAV1	4.64e-04	24	46	2	20624904
Pubmed	Reconstitution of human CMG helicase ubiquitylation by CUL2LRR1 and multiple E2 enzymes.	MCM5 HIF1A	4.64e-04	24	46	2	34195792
Pubmed	Binding of the proline-rich segment of myelin basic protein to SH3 domains: spectroscopic, microarray, and modeling studies of ligand conformation and effects of posttranslational modifications.	ABL1 VAV1	6.33e-04	28	46	2	18067320
Pubmed	Genome-wide association study of smoking behaviours in patients with COPD.	ASTN2 DBH	6.79e-04	29	46	2	21685187
Pubmed	Modulation of cAMP/cGMP signaling as prevention of congenital heart defects in Pde2A deficient embryos: a matter of oxidative stress.	C3 HIF1A	7.77e-04	31	46	2	38395995
Pubmed	SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome.	ABL1 VAV1	8.28e-04	32	46	2	22974441
Pubmed	USP11 mediates repair of DNA-protein cross-links by deubiquitinating SPRTN metalloprotease.	MCM5 PATZ1 RPL7A TUBAL3 RHOT1	8.80e-04	565	46	5	33567341
Pubmed	Functional proteomics mapping of a human signaling pathway.	DGCR2 USP13 RMND5A ZFYVE16 LIMS2	1.07e-03	591	46	5	15231748
Pubmed	Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury.	HIF1A NT5E	1.17e-03	38	46	2	20185832
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	ACAD10 ABL1 ACVR1 CSNK2B TUBAL3 LIMS2	1.21e-03	910	46	6	36736316
Cytoband	9q34	DBH RPL7A	1.36e-03	54	46	2	9q34
Cytoband	Ensembl 112 genes in cytogenetic band chr9q34	DBH ABL1 RPL7A	4.26e-03	325	46	3	chr9q34
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZBTB40 ZNF727 ZNF700 ZNF658 ZNF692 PATZ1	1.44e-03	718	32	6	28
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	ZBTB40 PATZ1 KLHL15	1.69e-03	134	32	3	861
GeneFamily	Clustered protocadherins	PCDHB10 PCDHB9	5.71e-03	64	32	2	20
Disease	hypertension (biomarker_via_orthology)	FAH C3 HIF1A DBH	2.51e-04	227	40	4	DOID:10763 (biomarker_via_orthology)
Disease	brain ischemia (biomarker_via_orthology)	C3 HIF1A DBH	3.61e-04	102	40	3	DOID:2316 (biomarker_via_orthology)
Disease	peptide measurement	DLC1 THRB LIMS2	4.39e-04	109	40	3	EFO_0010520
Disease	Cerebral Astrocytoma	HIF1A ACVR1	5.27e-04	25	40	2	C0750935
Disease	Intracranial Astrocytoma	HIF1A ACVR1	5.27e-04	25	40	2	C0750936
Disease	Pilocytic Astrocytoma	HIF1A ACVR1	5.27e-04	25	40	2	C0334583
Disease	Astrocytoma	HIF1A ACVR1	5.27e-04	25	40	2	C0004114
Disease	Juvenile Pilocytic Astrocytoma	HIF1A ACVR1	5.27e-04	25	40	2	C0280783
Disease	Diffuse Astrocytoma	HIF1A ACVR1	5.27e-04	25	40	2	C0280785
Disease	Grade I Astrocytoma	HIF1A ACVR1	5.27e-04	25	40	2	C1704230
Disease	Subependymal Giant Cell Astrocytoma	HIF1A ACVR1	5.27e-04	25	40	2	C0205768
Disease	Mixed oligoastrocytoma	HIF1A ACVR1	5.27e-04	25	40	2	C0547065
Disease	Childhood Cerebral Astrocytoma	HIF1A ACVR1	5.27e-04	25	40	2	C0338070
Disease	Gemistocytic astrocytoma	HIF1A ACVR1	5.70e-04	26	40	2	C0334581
Disease	Protoplasmic astrocytoma	HIF1A ACVR1	5.70e-04	26	40	2	C0334580
Disease	Fibrillary Astrocytoma	HIF1A ACVR1	5.70e-04	26	40	2	C0334582
Disease	Anaplastic astrocytoma	HIF1A ACVR1	6.16e-04	27	40	2	C0334579
Disease	lymphocyte count	C3 TMEM171 ACAD10 ABL1 RMND5A THRB VAV1 LIMS2	6.69e-04	1464	40	8	EFO_0004587
Disease	Adult T-Cell Lymphoma/Leukemia	VAV1 CSNK2B	8.13e-04	31	40	2	C0023493
Disease	macrophage colony stimulating factor measurement	ZBTB40 ABL1	1.16e-03	37	40	2	EFO_0008217
Disease	myocardial infarction (biomarker_via_orthology)	C3 HIF1A CSNK2B	1.33e-03	160	40	3	DOID:5844 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLDPLKNHMKYCCPD	ZNF280D	251	Q6N043
PKVNPKLYMCVCEGL	ACVR1	26	Q04771
YPKELRKCCEDGMRE	C3	686	P01024
SCMEGICKPDPRIYK	ACAD10	181	Q6JQN1
PAGELCRPKKDMCDL	ADAM8	461	P78325
CPEELKPMKDGSGCY	ASTN2	681	O75129
LMLSDVCEGPKCLKP	ASTN2	751	O75129
MKPVCKRCYEKFPLE	LIMS2	301	Q7Z4I7
PEVLGPEKYDKSCDM	MAPKAPK3	211	Q16644
KCPLDPYFIMPDKCK	MCM5	206	P33992
GYKKPPMTCLVLICE	HIF1A	211	Q16665
GPLYCPEEKEMKPAC	RHOT1	171	Q8IXI2
DREKLCGPKEPCMLY	PCDHB10	91	Q9UN67
KMESDGEKKYPCPEC	PATZ1	596	Q9HBE1
KEDEYPRMPCKLDGL	KLHL15	571	Q96M94
APMCRALKKLCDPDG	CRAMP1	291	Q96RY5
GPCDSKMKPDRLNYC	DBH	281	P09172
LLEKDYRMERPEGCP	ABL1	451	P00519
PEGCPEKVYELMRAC	ABL1	461	P00519
DIPGEAMVKLYCPKC	CSNK2B	126	P67870
RKDPKECCKFMCLDP	DGCR2	321	P98153
VFPDPEKPCKMCEAR	GET3	281	O43681
KPPVYGACKLLDMEL	FAH	186	P16930
CCRMDKKPDSLDLPS	LRCH2	306	Q5VUJ6
DREKLCGPKEPCMLY	PCDHB9	91	Q9Y5E1
KLACPVCSKMVPRYD	FAN1	41	Q9Y2M0
YKPLMDRPKCQGLES	PUS3	411	Q9BZE2
KLKCPYCPMEQSPGD	RMND5A	371	Q9H871
KPRDSKYPCSDKMEC	SAXO1	121	Q8IYX7
PALCRKMGVPYCIIK	RPL7A	171	P62424
KCDPRLGKYMACCLL	TUBAL3	311	A6NHL2
EPCGPGKSKLTYMCR	DLC1	1471	Q96QB1
CTKCRVPSYDPLKMD	NT5E	476	P21589
CDPNLDPKQYKMCLG	CHSY1	751	Q86X52
DHKPKECLGLLECMY	TSACC	56	Q96A04
IHMELRPYKCEECGK	ZNF727	361	A8MUV8
MPSGERPYKCSICEK	ZNF700	501	Q9H0M5
PPKMTEYDKRCCCLR	VAV1	186	P15498
FAKKLPMFCELPCED	THRB	286	P10828
PAYCTKEKLPCILMN	UNC13B	1161	O14795
ACQYKPLPDCPMVLK	TMEM171	46	Q8WVE6
ILMGEKPYECIECGK	ZNF658	511	Q5TYW1
KVCASERPPKDLGYM	USP13	841	Q92995
KAAKRELMPCDFPGC	ZNF692	321	Q9BU19
PLYMGRCSKPICDLI	ZFYVE16	116	Q7Z3T8
IEDPYDCKKCRMSFP	ZBTB40	946	Q9NUA8
ILMGEKPYECIECGK	ZNF658B	271	Q4V348
ENCEPKKMGPIRSYL	KIAA0319	86	Q5VV43