Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	TRPM6 MLKL FASTK SNRK MAPK8 MAPK9 MAP4K4 CDC42BPB MAP3K4	3.13e-05	446	72	9	GO:0004674
GeneOntologyMolecularFunction	cyclin-dependent protein serine/threonine kinase regulator activity	CCNL2 CCNT1 CCNT2 CCNL1	3.42e-05	51	72	4	GO:0016538
GeneOntologyMolecularFunction	JUN kinase activity	MAPK8 MAPK9	3.84e-05	3	72	2	GO:0004705
GeneOntologyMolecularFunction	protein serine kinase activity	TRPM6 FASTK SNRK MAPK8 MAPK9 MAP4K4 CDC42BPB MAP3K4	4.80e-05	363	72	8	GO:0106310
GeneOntologyMolecularFunction	protein kinase activity	TYK2 TRPM6 MLKL FASTK SNRK MAPK8 MAPK9 MAP4K4 CDC42BPB MAP3K4	5.58e-05	600	72	10	GO:0004672
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	TYK2 TRPM6 MLKL FKTN FASTK POLI SNRK MAPK8 MAPK9 MAP4K4 CDC42BPB MAP3K4	1.22e-04	938	72	12	GO:0016772
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	TYK2 TRPM6 MLKL FASTK SNRK MAPK8 MAPK9 MAP4K4 CDC42BPB MAP3K4	2.19e-04	709	72	10	GO:0016773
GeneOntologyMolecularFunction	kinase activity	TYK2 TRPM6 MLKL FASTK SNRK MAPK8 MAPK9 MAP4K4 CDC42BPB MAP3K4	3.98e-04	764	72	10	GO:0016301
GeneOntologyMolecularFunction	7SK snRNA binding	CCNT1 CCNT2	4.54e-04	9	72	2	GO:0097322
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF311 ZNF585A ZNF562 ZNF493 ZKSCAN1 ZNF268 ZNF436 ZNF816 NFKBIZ ZNF57 SIM1 ZNF639 ZNF518A ZNF461	6.26e-04	1459	72	14	GO:0000977
GeneOntologyMolecularFunction	kinase regulator activity	CCNL2 CCNT1 CCNT2 CCNL1 WDR81 RICTOR	8.11e-04	305	72	6	GO:0019207
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF311 ZNF585A ZNF562 ZNF493 ZKSCAN1 ZNF268 ZNF436 ZNF816 ZNF57 SIM1 ZNF639 ZNF518A ZNF461	1.47e-03	1412	72	13	GO:0000981
GeneOntologyMolecularFunction	cyclin-dependent protein serine/threonine kinase activator activity	CCNT1 CCNT2	1.49e-03	16	72	2	GO:0061575
GeneOntologyMolecularFunction	MAP kinase activity	MAPK8 MAPK9	1.49e-03	16	72	2	GO:0004707
GeneOntologyMolecularFunction	protein kinase regulator activity	CCNL2 CCNT1 CCNT2 CCNL1 RICTOR	2.44e-03	259	72	5	GO:0019887
GeneOntologyMolecularFunction	protein serine/threonine kinase activator activity	CCNT1 CCNT2 RICTOR	2.82e-03	78	72	3	GO:0043539
GeneOntologyMolecularFunction	enzyme regulator activity	RALGAPA1 CCNL2 CCNT1 CCNT2 PPP2R3A IPO7 CCNL1 CDC20B WDR81 RICTOR MAPK8 MAPK9	4.52e-03	1418	72	12	GO:0030234
GeneOntologyBiologicalProcess	determination of dorsal identity	CER1 MAPK8 MAP3K4	1.14e-05	13	72	3	GO:0048263
GeneOntologyBiologicalProcess	determination of dorsal/ventral asymmetry	CER1 MAPK8 MAP3K4	1.14e-05	13	72	3	GO:0048262
GeneOntologyBiologicalProcess	protein localization to tricellular tight junction	MAPK8 MAPK9	7.18e-05	4	72	2	GO:0061833
GeneOntologyCellularComponent	cyclin-dependent protein kinase holoenzyme complex	CCNL2 CCNT1 CCNT2 CCNL1	5.82e-05	61	72	4	GO:0000307
GeneOntologyCellularComponent	nuclear speck	CCNL2 FASTK CCNL1 POLI BARD1 NFKBIZ ASCC3 MAPK9	1.16e-04	431	72	8	GO:0016607
GeneOntologyCellularComponent	cyclin/CDK positive transcription elongation factor complex	CCNT1 CCNT2	4.15e-04	9	72	2	GO:0008024
GeneOntologyCellularComponent	transcription elongation factor complex	CCNT1 CCNT2 CCNL1	9.53e-04	56	72	3	GO:0008023
Domain	Cyclin_L/T	CCNL2 CCNT1 CCNT2 CCNL1	1.33e-08	8	71	4	IPR015429
Domain	CYCLINS	CCNL2 CCNT1 CCNT2 CCNL1	3.66e-06	28	71	4	PS00292
Domain	Cyclin_N	CCNL2 CCNT1 CCNT2 CCNL1	7.22e-06	33	71	4	IPR006671
Domain	Cyclin_N	CCNL2 CCNT1 CCNT2 CCNL1	7.22e-06	33	71	4	PF00134
Domain	KRAB	ZNF311 ZNF585A ZNF562 ZKSCAN1 ZNF268 ZNF436 ZNF816 ZNF57 ZNF461	8.26e-06	358	71	9	PS50805
Domain	KRAB	ZNF311 ZNF585A ZNF562 ZKSCAN1 ZNF268 ZNF436 ZNF816 ZNF57 ZNF461	8.26e-06	358	71	9	PF01352
Domain	KRAB	ZNF311 ZNF585A ZNF562 ZKSCAN1 ZNF268 ZNF436 ZNF816 ZNF57 ZNF461	1.05e-05	369	71	9	SM00349
Domain	zf-C2H2	ZNF311 ZNF585A ZNF562 ZNF493 ZKSCAN1 ZNF268 ZNF436 ZNF816 ZNF57 ZNF639 ZNF518A ZNF461	1.06e-05	693	71	12	PF00096
Domain	KRAB	ZNF311 ZNF585A ZNF562 ZKSCAN1 ZNF268 ZNF436 ZNF816 ZNF57 ZNF461	1.08e-05	370	71	9	IPR001909
Domain	Znf_C2H2/integrase_DNA-bd	ZNF311 ZNF585A ZNF562 ZNF493 ZKSCAN1 ZNF268 ZNF436 ZNF816 ZNF57 ZNF639 ZNF518A ZNF461	1.08e-05	694	71	12	IPR013087
Domain	CYCLIN	CCNL2 CCNT1 CCNT2 CCNL1	1.28e-05	38	71	4	SM00385
Domain	-	CCNL2 CCNT1 CCNT2 CCNL1	1.58e-05	40	71	4	1.10.472.10
Domain	Cyclin-like	CCNL2 CCNT1 CCNT2 CCNL1	2.12e-05	43	71	4	IPR013763
Domain	ZINC_FINGER_C2H2_2	ZNF311 ZNF585A ZNF562 ZNF493 ZKSCAN1 ZNF268 ZNF436 ZNF816 ZNF57 ZNF639 ZNF518A ZNF461	3.22e-05	775	71	12	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF311 ZNF585A ZNF562 ZNF493 ZKSCAN1 ZNF268 ZNF436 ZNF816 ZNF57 ZNF639 ZNF518A ZNF461	3.30e-05	777	71	12	PS00028
Domain	Kinase-like_dom	TYK2 TRPM6 MLKL WDR81 SNRK MAPK8 MAPK9 MAP4K4 CDC42BPB MAP3K4	3.67e-05	542	71	10	IPR011009
Domain	Znf_C2H2-like	ZNF311 ZNF585A ZNF562 ZNF493 ZKSCAN1 ZNF268 ZNF436 ZNF816 ZNF57 ZNF639 ZNF518A ZNF461	4.18e-05	796	71	12	IPR015880
Domain	Znf_C2H2	ZNF311 ZNF585A ZNF562 ZNF493 ZKSCAN1 ZNF268 ZNF436 ZNF816 ZNF57 ZNF639 ZNF518A ZNF461	4.66e-05	805	71	12	IPR007087
Domain	-	ZNF311 ZNF585A ZNF562 ZNF493 ZKSCAN1 ZNF268 ZNF436 ZNF816 ZNF57 ZNF639 ZNF461	4.75e-05	679	71	11	3.30.160.60
Domain	ZnF_C2H2	ZNF311 ZNF585A ZNF562 ZNF493 ZKSCAN1 ZNF268 ZNF436 ZNF816 ZNF57 ZNF639 ZNF518A ZNF461	4.83e-05	808	71	12	SM00355
Domain	MAPK_JNK	MAPK8 MAPK9	1.41e-04	5	71	2	IPR008351
Domain	Prot_kinase_dom	TYK2 MLKL SNRK MAPK8 MAPK9 MAP4K4 CDC42BPB MAP3K4	5.22e-04	489	71	8	IPR000719
Domain	PROTEIN_KINASE_DOM	TYK2 MLKL SNRK MAPK8 MAPK9 MAP4K4 CDC42BPB MAP3K4	5.51e-04	493	71	8	PS50011
Domain	Pkinase	MLKL SNRK MAPK8 MAPK9 MAP4K4 CDC42BPB MAP3K4	6.03e-04	381	71	7	PF00069
Domain	MAP_kinase_CS	MAPK8 MAPK9	9.18e-04	12	71	2	IPR003527
Domain	Mab-21_dom	MAB21L4 ITPRIPL1	9.18e-04	12	71	2	IPR024810
Domain	MAPK	MAPK8 MAPK9	9.18e-04	12	71	2	PS01351
Domain	Mab-21	MAB21L4 ITPRIPL1	9.18e-04	12	71	2	PF03281
Domain	Mab-21	MAB21L4 ITPRIPL1	9.18e-04	12	71	2	SM01265
Domain	CNH	MAP4K4 CDC42BPB	1.26e-03	14	71	2	SM00036
Domain	CNH	MAP4K4 CDC42BPB	1.45e-03	15	71	2	PF00780
Domain	CNH	MAP4K4 CDC42BPB	1.45e-03	15	71	2	PS50219
Domain	CNH_dom	MAP4K4 CDC42BPB	1.45e-03	15	71	2	IPR001180
Domain	PROTEIN_KINASE_ATP	TYK2 SNRK MAPK8 MAPK9 MAP4K4 CDC42BPB MAP3K4	1.77e-03	459	71	7	PS00107
Domain	Cyclin_C	CCNL2 CCNL1	1.87e-03	17	71	2	PF02984
Domain	Cyclin_C-dom	CCNL2 CCNL1	1.87e-03	17	71	2	IPR004367
Domain	Cyclin_C	CCNL2 CCNL1	1.87e-03	17	71	2	SM01332
Domain	Ser/Thr_kinase_AS	SNRK MAPK8 MAPK9 MAP4K4 CDC42BPB MAP3K4	2.36e-03	357	71	6	IPR008271
Domain	S_TKc	SNRK MAPK8 MAPK9 MAP4K4 CDC42BPB MAP3K4	2.42e-03	359	71	6	SM00220
Domain	PROTEIN_KINASE_ST	SNRK MAPK8 MAPK9 MAP4K4 CDC42BPB MAP3K4	2.53e-03	362	71	6	PS00108
Pathway	WP_ONCOSTATIN_M_SIGNALING	TYK2 RICTOR MAPK8 MAPK9	1.26e-04	65	56	4	M39562
Pathway	KEGG_MEDICUS_ENV_FACTOR_PARAQUAT_TO_FAS_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9	1.54e-04	5	56	2	M49021
Pathway	KEGG_MEDICUS_PATHOGEN_HTLV_1_TAX_TO_TNF_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9	1.54e-04	5	56	2	M49005
Pathway	KEGG_MEDICUS_PATHOGEN_HIV_VPR_TAT_TO_TNF_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9	1.54e-04	5	56	2	M47570
Pathway	WP_ANGIOPOIETINLIKE_PROTEIN_8_REGULATORY_PATHWAY	RICTOR MAPK8 MAPK9 MAP4K4 MAP3K4	1.74e-04	132	56	5	M39338
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_TNF_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9	2.30e-04	6	56	2	M47680
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_IRE1A_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9	2.30e-04	6	56	2	M47698
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_DJ1_TO_FAS_JNK_SIGNALING_PATWHAY	MAPK8 MAPK9	2.30e-04	6	56	2	M47712
Pathway	BIOCARTA_MAPK_PATHWAY	MAPK8 MAPK9 MAP4K4 MAP3K4	2.32e-04	76	56	4	MM1433
Pathway	WP_REGULATORY_CIRCUITS_OF_STAT3_SIGNALING	TYK2 RICTOR MAPK8 MAPK9	2.56e-04	78	56	4	M39824
Pathway	BIOCARTA_MAPK_PATHWAY	MAPK8 MAPK9 MAP4K4 MAP3K4	2.96e-04	81	56	4	M13863
Pathway	KEGG_MEDICUS_REFERENCE_IRE1A_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9	3.21e-04	7	56	2	M47697
Pathway	KEGG_MEDICUS_REFERENCE_FAS_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9	3.21e-04	7	56	2	M47711
Pathway	WP_HOSTPATHOGEN_INTERACTION_OF_HUMAN_CORONAVIRUSES_MAPK_SIGNALING	MAPK8 MAPK9 MAP3K4	3.86e-04	36	56	3	M39908
Pathway	REACTOME_OXIDATIVE_STRESS_INDUCED_SENESCENCE	MAPK8 MAPK9 MAP4K4	4.19e-04	37	56	3	MM14899
Pathway	KEGG_MEDICUS_ENV_FACTOR_METALS_TO_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9	4.27e-04	8	56	2	M47814
Pathway	WP_IL6_SIGNALING_PATHWAY	TYK2 PPP2R3A MAPK8 MAP3K4	6.60e-04	100	56	4	MM15826
Pathway	REACTOME_ACTIVATION_OF_THE_AP_1_FAMILY_OF_TRANSCRIPTION_FACTORS	MAPK8 MAPK9	6.83e-04	10	56	2	MM15135
Pathway	REACTOME_ACTIVATION_OF_THE_AP_1_FAMILY_OF_TRANSCRIPTION_FACTORS	MAPK8 MAPK9	6.83e-04	10	56	2	M13962
Pathway	WP_IL26_SIGNALING	TYK2 MAPK8 MAPK9	8.51e-04	47	56	3	M48074
Pathway	WP_MECHANOREGULATION_AND_PATHOLOGY_OF_YAPTAZ_VIA_HIPPO_AND_NONHIPPO_MECHANISMS	MAPK8 MAPK9 MAP4K4	8.51e-04	47	56	3	M39829
Pathway	WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT	MLKL MAPK8 MAPK9 MAP3K4	9.43e-04	110	56	4	M39492
Pathway	KEGG_MEDICUS_REFERENCE_MLK_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9	9.97e-04	12	56	2	M47929
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_JNK_SIGNALING_PATHWAY	MAPK8 MAPK9	1.18e-03	13	56	2	M47594
Pubmed	The Cdk9 and cyclin T subunits of TAK/P-TEFb localize to splicing factor-rich nuclear speckle regions.	CCNT1 CCNT2 ZMYM6	3.40e-08	4	72	3	11282025
Pubmed	Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development.	MAPK8 MAPK9 MAP3K4	3.40e-08	4	72	3	15731347
Pubmed	JNK signaling prevents biliary cyst formation through a CASPASE-8-dependent function of RIPK1 during aging.	MLKL MAPK8 MAPK9	8.48e-08	5	72	3	33798093
Pubmed	Combinatorial CRISPR screen identifies fitness effects of gene paralogues.	FNIP2 CCNL2 MLKL CCNT1 CCNT2 CCNL1	2.52e-06	186	72	6	33637726
Pubmed	JNK-dependent Stat3 phosphorylation contributes to Akt activation in response to arsenic exposure.	MAPK8 MAPK9	4.23e-06	2	72	2	22696236
Pubmed	C-Jun N-terminal kinase (JNK) isoforms play differing roles in otitis media.	MAPK8 MAPK9	4.23e-06	2	72	2	25311344
Pubmed	Genetic inhibition or activation of JNK1/2 protects the myocardium from ischemia-reperfusion-induced cell death in vivo.	MAPK8 MAPK9	4.23e-06	2	72	2	16043490
Pubmed	Combined Activities of JNK1 and JNK2 in Hepatocytes Protect Against Toxic Liver Injury.	MAPK8 MAPK9	4.23e-06	2	72	2	26708719
Pubmed	Ablation of the spindle assembly checkpoint by a compound targeting Mps1.	MAPK8 MAPK9	4.23e-06	2	72	2	16113653
Pubmed	c-Jun N-terminal kinase 1 is deleterious to the function and survival of murine pancreatic islets.	MAPK8 MAPK9	4.23e-06	2	72	2	18853132
Pubmed	Ultrafine particles from diesel engines induce vascular oxidative stress via JNK activation.	MAPK8 MAPK9	4.23e-06	2	72	2	19154785
Pubmed	Role of the MAPK/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy.	MAPK8 MAPK9	4.23e-06	2	72	2	29950132
Pubmed	Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance.	MAPK8 MAPK9	4.23e-06	2	72	2	16818881
Pubmed	Specific role of JNK in the maintenance of the tumor-initiating capacity of A549 human non-small cell lung cancer cells.	MAPK8 MAPK9	4.23e-06	2	72	2	23912840
Pubmed	Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1.	MAPK8 MAPK9	4.23e-06	2	72	2	12857751
Pubmed	JNK1, but not JNK2, is required in two mechanistically distinct models of inflammatory arthritis.	MAPK8 MAPK9	4.23e-06	2	72	2	21839715
Pubmed	JNK is required for maintaining the tumor-initiating cell-like properties of acquired chemoresistant human cancer cells.	MAPK8 MAPK9	4.23e-06	2	72	2	26235742
Pubmed	Prevention of steatosis by hepatic JNK1.	MAPK8 MAPK9	4.23e-06	2	72	2	19945406
Pubmed	C-Jun NH(2)-terminal kinase mediates proliferation and tumor growth of human prostate carcinoma.	MAPK8 MAPK9	4.23e-06	2	72	2	12538493
Pubmed	Hypothermia attenuates ischemia/reperfusion-induced endothelial cell apoptosis via alterations in apoptotic pathways and JNK signaling.	MAPK8 MAPK9	4.23e-06	2	72	2	19596001
Pubmed	Inhibition of Jun NH2-terminal kinases suppresses the growth of experimental head and neck squamous cell carcinoma.	MAPK8 MAPK9	4.23e-06	2	72	2	17908987
Pubmed	c-Jun N-terminal kinase 1/2 activation by tumor necrosis factor-alpha induces insulin resistance in human visceral but not subcutaneous adipocytes: reversal by liver X receptor agonists.	MAPK8 MAPK9	4.23e-06	2	72	2	19567513
Pubmed	Increased JNK in males compared with females in a rodent model of abdominal aortic aneurysm.	MAPK8 MAPK9	4.23e-06	2	72	2	22316675
Pubmed	Defective antiviral CD8 T-cell response and viral clearance in the absence of c-Jun N-terminal kinases.	MAPK8 MAPK9	4.23e-06	2	72	2	24673683
Pubmed	c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis.	MAPK8 MAPK9	4.23e-06	2	72	2	11435459
Pubmed	[Sodium butyrate do not induce the program of premature senescence in transformants with JNK1,2 knockout].	MAPK8 MAPK9	4.23e-06	2	72	2	19140343
Pubmed	Modulation of the response of prostate cancer cell lines to cisplatin treatment using small interfering RNA.	MAPK8 MAPK9	4.23e-06	2	72	2	23900581
Pubmed	Inhibition of c-Jun N-terminal kinase attenuates low shear stress-induced atherogenesis in apolipoprotein E-deficient mice.	MAPK8 MAPK9	4.23e-06	2	72	2	21629969
Pubmed	c-Jun N-terminal protein kinase 1 (JNK1), but not JNK2, is essential for tumor necrosis factor alpha-induced c-Jun kinase activation and apoptosis.	MAPK8 MAPK9	4.23e-06	2	72	2	15572687
Pubmed	Hepatotoxicity mediated by pyrazole (cytochrome P450 2E1) plus tumor necrosis factor alpha treatment occurs in c-Jun N-terminal kinase 2-/- but not in c-Jun N-terminal kinase 1-/- mice.	MAPK8 MAPK9	4.23e-06	2	72	2	21748763
Pubmed	Purinergic (ATP) signaling stimulates JNK1 but not JNK2 MAPK in osteoblast-like cells: contribution of intracellular Ca2+ release, stress activated and L-voltage-dependent calcium influx, PKC and Src kinases.	MAPK8 MAPK9	4.23e-06	2	72	2	18625195
Pubmed	The JNKs differentially regulate RNA polymerase III transcription by coordinately modulating the expression of all TFIIIB subunits.	MAPK8 MAPK9	4.23e-06	2	72	2	19620725
Pubmed	Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathway.	MAPK8 MAPK9	4.23e-06	2	72	2	16571730
Pubmed	JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration.	MAPK8 MAPK9	4.23e-06	2	72	2	23341606
Pubmed	c-Jun N-terminal kinase 2 promotes enterocyte survival and goblet cell differentiation in the inflamed intestine.	MAPK8 MAPK9	4.23e-06	2	72	2	28098247
Pubmed	c-Jun N-terminal kinase is upregulated in patients with hypospadias.	MAPK8 MAPK9	4.23e-06	2	72	2	23273084
Pubmed	An initial phase of JNK activation inhibits cell death early in the endoplasmic reticulum stress response.	MAPK8 MAPK9	4.23e-06	2	72	2	27122189
Pubmed	JNK2 up-regulates hypoxia-inducible factors and contributes to hypoxia-induced erythropoiesis and pulmonary hypertension.	MAPK8 MAPK9	4.23e-06	2	72	2	29118187
Pubmed	Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2.	MAPK8 MAPK9	4.23e-06	2	72	2	10559486
Pubmed	c-Jun N-terminal kinase activity is required for efficient respiratory syncytial virus production.	MAPK8 MAPK9	4.23e-06	2	72	2	28062184
Pubmed	JNK regulates muscle remodeling via myostatin/SMAD inhibition.	MAPK8 MAPK9	4.23e-06	2	72	2	30072727
Pubmed	c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have distinct roles in CD8(+) T cell activation.	MAPK8 MAPK9	4.23e-06	2	72	2	11927626
Pubmed	c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 signaling pathways have divergent roles in CD8(+) T cell-mediated antiviral immunity.	MAPK8 MAPK9	4.23e-06	2	72	2	11927625
Pubmed	Efficient keratinocyte differentiation strictly depends on JNK-induced soluble factors in fibroblasts.	MAPK8 MAPK9	4.23e-06	2	72	2	24335928
Pubmed	Inhibition of cell proliferation and cell cycle progression by specific inhibition of basal JNK activity: evidence that mitotic Bcl-2 phosphorylation is JNK-independent.	MAPK8 MAPK9	4.23e-06	2	72	2	14704147
Pubmed	Inhibition of JNK reduces G2/M transit independent of p53, leading to endoreduplication, decreased proliferation, and apoptosis in breast cancer cells.	MAPK8 MAPK9	4.23e-06	2	72	2	14724588
Pubmed	Coordination of JNK1 and JNK2 is critical for GADD45alpha induction and its mediated cell apoptosis in arsenite responses.	MAPK8 MAPK9	4.23e-06	2	72	2	16973625
Pubmed	Differential roles of JNK in ConA/GalN and ConA-induced liver injury in mice.	MAPK8 MAPK9	4.23e-06	2	72	2	18772342
Pubmed	c-Jun NH2-terminal kinase-2 mediates osmotic stress-induced tight junction disruption in the intestinal epithelium.	MAPK8 MAPK9	4.23e-06	2	72	2	20595622
Pubmed	c-Jun NH2-terminal kinase is required for lineage-specific differentiation but not stem cell self-renewal.	MAPK8 MAPK9	4.23e-06	2	72	2	20065035
Pubmed	Inhibited neurogenesis in JNK1-deficient embryonic stem cells.	MAPK8 MAPK9	4.23e-06	2	72	2	16314504
Pubmed	c-Jun N-terminal kinase 2 suppresses pancreatic cancer growth and invasion and is opposed by c-Jun N-terminal kinase 1.	MAPK8 MAPK9	4.23e-06	2	72	2	33526844
Pubmed	JNK1 and 2 play a negative role in reprogramming to pluripotent stem cells by suppressing Klf4 activity.	MAPK8 MAPK9	4.23e-06	2	72	2	24211391
Pubmed	Protective role of c-Jun N-terminal kinase-2 (JNK2) in ibuprofen-induced acute liver injury.	MAPK8 MAPK9	4.23e-06	2	72	2	30264435
Pubmed	Decreased expression of phosphorylated JNK in breast infiltrating ductal carcinoma is associated with a better overall survival.	MAPK8 MAPK9	4.23e-06	2	72	2	16381010
Pubmed	Protective role of c-Jun N-terminal kinase 2 in acetaminophen-induced liver injury.	MAPK8 MAPK9	4.23e-06	2	72	2	18586006
Pubmed	JNK/SAPK Signaling Is Essential for Efficient Reprogramming of Human Fibroblasts to Induced Pluripotent Stem Cells.	MAPK8 MAPK9	4.23e-06	2	72	2	26867034
Pubmed	c-Jun N-terminal kinase 2 (JNK2) antagonizes the signaling of differentiation by JNK1 in human myeloid leukemia cells resistant to vitamin D.	MAPK8 MAPK9	4.23e-06	2	72	2	19339050
Pubmed	Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-beta1.	MAPK8 MAPK9	4.23e-06	2	72	2	18334556
Pubmed	A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis.	MAPK8 MAPK9	4.23e-06	2	72	2	17202416
Pubmed	Deletion of JNK Enhances Senescence in Joint Tissues and Increases the Severity of Age-Related Osteoarthritis in Mice.	MAPK8 MAPK9	4.23e-06	2	72	2	32418287
Pubmed	The role of JNK in the development of hepatocellular carcinoma.	MAPK8 MAPK9	4.23e-06	2	72	2	21406557
Pubmed	JNK1/2 regulates ER-mitochondrial Ca2+ cross-talk during IL-1β-mediated cell death in RINm5F and human primary β-cells.	MAPK8 MAPK9	4.23e-06	2	72	2	23615449
Pubmed	Genetic deletion of JNK1 and JNK2 aggravates the DSS-induced colitis in mice.	MAPK8 MAPK9	4.23e-06	2	72	2	17365404
Pubmed	Signal transduction by the JNK group of MAP kinases.	MAPK8 MAPK9	4.23e-06	2	72	2	11057897
Pubmed	Effect of Jun N-terminal kinase 1 and 2 on the replication of Penicillium marneffei in human macrophages.	MAPK8 MAPK9	4.23e-06	2	72	2	25792289
Pubmed	Silencing Jnk1 and Jnk2 accelerates basal lipolysis and promotes fatty acid re-esterification in mouse adipocytes.	MAPK8 MAPK9	4.23e-06	2	72	2	18528680
Pubmed	Oppositional regulation of Noxa by JNK1 and JNK2 during apoptosis induced by proteasomal inhibitors.	MAPK8 MAPK9	1.27e-05	3	72	2	23593480
Pubmed	JNK Isoforms Are Involved in the Control of Adult Hippocampal Neurogenesis in Mice, Both in Physiological Conditions and in an Experimental Model of Temporal Lobe Epilepsy.	MAPK8 MAPK9	1.27e-05	3	72	2	30685843
Pubmed	Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: influence of cyclin L isoforms on splice site selection.	CCNL2 CCNL1	1.27e-05	3	72	2	18216018
Pubmed	Overexpression or ablation of JNK in skeletal muscle has no effect on glycogen synthase activity.	MAPK8 MAPK9	1.27e-05	3	72	2	15013949
Pubmed	Arrestin-3 binds c-Jun N-terminal kinase 1 (JNK1) and JNK2 and facilitates the activation of these ubiquitous JNK isoforms in cells via scaffolding.	MAPK8 MAPK9	1.27e-05	3	72	2	24257757
Pubmed	MEK kinase 1 activity is required for definitive erythropoiesis in the mouse fetal liver.	MAPK8 MAPK9	1.27e-05	3	72	2	16081685
Pubmed	Inhibition of C-jun N-terminal kinase improves insulin sensitivity but worsens albuminuria in experimental diabetes.	MAPK8 MAPK9	1.27e-05	3	72	2	18971923
Pubmed	Regulation of P-TEFb elongation complex activity by CDK9 acetylation.	CCNT1 CCNT2	1.27e-05	3	72	2	17452463
Pubmed	A central role for JNK in obesity and insulin resistance.	MAPK8 MAPK9	1.27e-05	3	72	2	12447443
Pubmed	Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis.	MAPK8 MAPK9	1.27e-05	3	72	2	19433446
Pubmed	JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis.	MAPK8 MAPK9	1.27e-05	3	72	2	21364637
Pubmed	JNK1 is required to preserve cardiac function in the early response to pressure overload.	MAPK8 MAPK9	1.27e-05	3	72	2	16579967
Pubmed	(-)-Epigallocatechin-3-gallate promotes pro-matrix metalloproteinase-7 production via activation of the JNK1/2 pathway in HT-29 human colorectal cancer cells.	MAPK8 MAPK9	1.27e-05	3	72	2	15860507
Pubmed	Both JNK1 and JNK2 Are Indispensable for Sensitized Extracellular Matrix Mineralization in IKKβ-Deficient Osteoblasts.	MAPK8 MAPK9	1.27e-05	3	72	2	32117051
Pubmed	Interaction of Neisseria meningitidis with human brain microvascular endothelial cells: role of MAP- and tyrosine kinases in invasion and inflammatory cytokine release.	MAPK8 MAPK9	1.27e-05	3	72	2	15527495
Pubmed	Dual specificity phosphatase16 is a negative regulator of c-Jun NH2-terminal kinase activity in T cells.	MAPK8 MAPK9	1.27e-05	3	72	2	20377744
Pubmed	The TAK1-JNK cascade is required for IRF3 function in the innate immune response.	MAPK8 MAPK9	1.27e-05	3	72	2	19153595
Pubmed	Specific pathophysiological functions of JNK isoforms in the brain.	MAPK8 MAPK9	1.27e-05	3	72	2	15673436
Pubmed	Role of JNK in a Trp53-dependent mouse model of breast cancer.	MAPK8 MAPK9	1.27e-05	3	72	2	20814571
Pubmed	c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation.	MAPK8 MAPK9	1.27e-05	3	72	2	11157052
Pubmed	JNK1 Induces Notch1 Expression to Regulate Genes Governing Photoreceptor Production.	MAPK8 MAPK9	1.27e-05	3	72	2	31450635
Pubmed	c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade.	MAPK8 MAPK9	1.27e-05	3	72	2	12417588
Pubmed	JNK phosphorylates beta-catenin and regulates adherens junctions.	MAPK8 MAPK9	1.27e-05	3	72	2	19667122
Pubmed	JNK2 modulates the CD1d-dependent and -independent activation of iNKT cells.	MAPK8 MAPK9	1.27e-05	3	72	2	30467836
Pubmed	Cyclin T2 is essential for mouse embryogenesis.	CCNT1 CCNT2	1.27e-05	3	72	2	19364821
Pubmed	Requirement of the JIP1 scaffold protein for stress-induced JNK activation.	MAPK8 MAPK9	1.27e-05	3	72	2	11562351
Pubmed	JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins.	MAPK8 MAPK9	1.27e-05	3	72	2	12689591
Pubmed	Role of the human and murine cyclin T proteins in regulating HIV-1 tat-activation.	CCNT1 CCNT2	1.27e-05	3	72	2	10329126
Pubmed	Identification of multiple cyclin subunits of human P-TEFb.	CCNT1 CCNT2	1.27e-05	3	72	2	9499409
Pubmed	Cepharanthine triggers apoptosis in a human hepatocellular carcinoma cell line (HuH-7) through the activation of JNK1/2 and the downregulation of Akt.	MAPK8 MAPK9	1.27e-05	3	72	2	16412424
Pubmed	Melatonin attenuates osteosarcoma cell invasion by suppression of C-C motif chemokine ligand 24 through inhibition of the c-Jun N-terminal kinase pathway.	MAPK8 MAPK9	1.27e-05	3	72	2	29766567
Pubmed	Identification of nucleolar effects in JNK-deficient cells.	MAPK8 MAPK9	1.27e-05	3	72	2	18703060
Pubmed	JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation.	MAPK8 MAPK9	1.27e-05	3	72	2	8001819
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF311 ZNF585A ZNF562 ZNF493 ZKSCAN1 ZNF268 ZNF436 ZNF816 ZNF57 ZNF639 ZNF518A ZNF461	6.72e-07	718	52	12	28
GeneFamily	Cyclins	CCNL2 CCNT1 CCNT2 CCNL1	1.18e-06	28	52	4	473
GeneFamily	Cyclins\|P-TEFb complex	CCNT1 CCNT2	4.85e-05	4	52	2	1281
GeneFamily	Mitogen-activated protein kinases	MAPK8 MAPK9	6.20e-04	13	52	2	651
Coexpression	LAKE_ADULT_KIDNEY_C14_DISTAL_CONVOLUTED_TUBULE	TRPM6 RALGAPA1 PPP2R3A FHOD3 MAPK8 LRP1B ZNF518A	1.70e-06	208	72	7	M39233
Coexpression	LAKE_ADULT_KIDNEY_C17_COLLECTING_SYSTEM_PCS_STRESSED_DISSOC_SUBSET	FNIP2 RALGAPA1 CCNL1 NFKBIZ FHOD3 MAPK8 LRP1B	4.39e-06	240	72	7	M39236
Coexpression	GSE17301_IFNA2_VS_IFNA2_AND_ACD3_ACD28_STIM_CD8_TCELL_UP	RALGAPA1 ZNF493 AVL9 FKTN DDX60 XPC	1.88e-05	200	72	6	M8042
Coexpression	GSE34006_A2AR_KO_VS_A2AR_AGONIST_TREATED_TREG_DN	CCNL2 AVL9 TTI2 MAPK8 MAP4K4 ZNF639	1.88e-05	200	72	6	M9049
Coexpression	GSE39820_TGFBETA1_IL6_VS_TGFBETA1_IL6_IL23A_TREATED_CD4_TCELL_UP	FNIP2 ZKSCAN1 FKTN WDR81 MAPK9 MAP3K4	1.88e-05	200	72	6	M5617
Coexpression	XU_HGF_TARGETS_INDUCED_BY_AKT1_48HR_DN	ZNF268 CCNL1 KIF14	3.38e-05	23	72	3	M18912
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_XPCS_UP	CCNT2 ZKSCAN1 CTH	4.38e-05	25	72	3	M18122
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TRPM6 PPP2R3A CCNL1 NFKBIZ FHOD3 SIM1 LRP1B	2.16e-08	186	72	7	08632045d499e61dd96ff29a5a9a208afe58dc58
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	CCNT1 CCNT2 AVL9 CDIN1 KIF14 MAP3K4	5.56e-07	185	72	6	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TRPM6 PPP2R3A CCNL1 NFKBIZ FHOD3 LRP1B	5.74e-07	186	72	6	d65fa6d8e8a195ea10cfde1499d096d6acf7a634
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	CCNT1 CCNT2 AVL9 CDIN1 KIF14 MAP3K4	5.74e-07	186	72	6	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	COVID-19-kidney-CNT\|kidney / Disease (COVID-19 only), tissue and cell type	TRPM6 PPP2R3A NFKBIZ FHOD3 SIM1 LRP1B	6.90e-07	192	72	6	d32ae226d95b4b6adb99d14b602be09b661d4cd9
ToppCell	facs-Lung-Endomucin-3m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNIP2 ANK2 MAB21L4 POLI PDE5A	8.04e-06	169	72	5	2d23b4cee060f8adddc430c1c10d4e25205b4af6
ToppCell	facs-Lung-Endomucin-3m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNIP2 ANK2 MAB21L4 POLI PDE5A	8.04e-06	169	72	5	ecaf08e8e0b54d1c97a02bc1f65409fd43d68227
ToppCell	facs-Lung-Endomucin-3m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNIP2 ANK2 MAB21L4 POLI PDE5A	8.04e-06	169	72	5	ad6af6609acf158cb79e45ee7ca9af332be3c40c
ToppCell	CV-Healthy-7\|CV / Virus stimulation, Condition and Cluster	CCNT1 ZKSCAN1 ZNF268 SNX25 ZMYM6	1.21e-05	184	72	5	0e5cc77aaa73ceb791f8be7456177577fd2e5586
ToppCell	CV-Healthy-7\|Healthy / Virus stimulation, Condition and Cluster	CCNT1 ZKSCAN1 ZNF268 SNX25 ZMYM6	1.25e-05	185	72	5	1979d189c204f4c2893e3170a514ee7d5523406c
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CRYL1 PPP2R3A ANK2 FHOD3 SIM1	1.25e-05	185	72	5	03f64a7132b13a01ba47187e0e15c13ac88f7cb2
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CRYL1 PPP2R3A ANK2 FHOD3 SIM1	1.28e-05	186	72	5	1850583d23903d08226aeb0edb3e07b0994330e4
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CRYL1 PPP2R3A ANK2 FHOD3 SIM1	1.28e-05	186	72	5	4dafc215c42e7949f932a3627359c107943b5d6b
ToppCell	COVID-19-kidney-DCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TRPM6 PPP2R3A FHOD3 SIM1 LRP1B	1.35e-05	188	72	5	1d56cd409793f05cca20757ab26e91f1a1ee67b5
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|RV / Chamber and Cluster_Paper	PPP2R3A ANK2 KCND3 CDIN1 FHOD3	1.38e-05	189	72	5	9c1debd65c13d63fd4f3158917d621b44b714c26
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	PPP2R3A ANK2 KCND3 CDIN1 FHOD3	1.38e-05	189	72	5	5e80c47f63980904c4c1ff02c201b67b456a0974
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|RV / Chamber and Cluster_Paper	PPP2R3A ANK2 KCND3 CDIN1 FHOD3	1.42e-05	190	72	5	fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|LV / Chamber and Cluster_Paper	PPP2R3A ANK2 KCND3 CDIN1 FHOD3	1.45e-05	191	72	5	25f3eb34f4e70761e81e84c8a5829f216108cbc6
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|LV / Chamber and Cluster_Paper	PPP2R3A ANK2 KCND3 CDIN1 FHOD3	1.49e-05	192	72	5	ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	FNIP2 PPP2R3A ANK2 CDIN1 FHOD3	1.53e-05	193	72	5	dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCell	COVID-19-Heart-CM_1\|Heart / Disease (COVID-19 only), tissue and cell type	PPP2R3A ANK2 KCND3 CDIN1 FHOD3	1.61e-05	195	72	5	f1ef50331eda8f1239dba6ea970df4eaccf032f1
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CRYL1 PPP2R3A ANK2 FHOD3 SIM1	1.65e-05	196	72	5	eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCell	Bronchial-NucSeq-Stromal-Chondrocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ZKSCAN1 SLC30A8 CTH LRP1B TAFA2	1.81e-05	200	72	5	b7b9441fa7ab0d43741a2ebd5ec1a48d537c6d47
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	MLKL DDX60 SNRK CTH MAP4K4	1.81e-05	200	72	5	89821a264e872ed53e08e9d3609d5cc5c314503e
ToppCell	Bronchial-NucSeq-Stromal-Chondrocytic-Chondrocyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ZKSCAN1 SLC30A8 CTH LRP1B TAFA2	1.81e-05	200	72	5	7c673ad0ea503ebd196579684d25d5f9e6a41030
ToppCell	TCGA-Thryoid-Solid_Tissue_Normal-Thryoid_normal_tissue-Thryoid_normal_tissue-3\|TCGA-Thryoid / Sample_Type by Project: Shred V9	ANK2 CCDC146 CTH LRP1B	1.13e-04	154	72	4	4e9203c220a44c70cd7979796a0b461991422257
ToppCell	BAL-Mild-Myeloid-Neutrophil-Neutrophil-Neu_3\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	AVL9 NFKBIZ TAFA2	1.46e-04	63	72	3	1c8f4d173a6348cf5ea3d7d099b48dabc15d07ac
ToppCell	BAL-Mild-Myeloid-Neutrophil-Neutrophil\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	AVL9 NFKBIZ TAFA2	1.46e-04	63	72	3	9c108339b9d03a5f88de61c25e4ba920138245cc
ToppCell	Mild_COVID-19-Myeloid-Neutrophil\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	AVL9 NFKBIZ TAFA2	1.46e-04	63	72	3	de62e0692cda074dffb036c2d276ac33656c8a43
ToppCell	BAL-Mild-Myeloid-Neutrophil\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	AVL9 NFKBIZ TAFA2	1.46e-04	63	72	3	8874c58f3996f98323ca894647a25569727e3652
ToppCell	BAL-Mild-Myeloid-Neutrophil-Neutrophil-Neu_3\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	AVL9 NFKBIZ TAFA2	1.46e-04	63	72	3	63471d9ae567d3275561729048a4cb78407d28f6
ToppCell	BAL-Mild-Myeloid-Neutrophil-Neutrophil\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	AVL9 NFKBIZ TAFA2	1.46e-04	63	72	3	13aa61e3d54d7290df7ef982c70b2b4e9f6c7a32
ToppCell	BAL-Mild-Myeloid-Neutrophil\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	AVL9 NFKBIZ TAFA2	1.46e-04	63	72	3	bc8a5e40d828110c650a4760eaf682dbfacd8b5b
ToppCell	NS-critical-d_0-4-Myeloid-Monocyte-derived_Macrophage\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	LZTR1 POLI ZNF816 ZNF57	1.66e-04	170	72	4	adf73bdc049d508f8873c22539db2ca92052a97b
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TYK2 MLKL WDR81 ZMYM6	1.85e-04	175	72	4	bb898796662b97f7459b7dda7cecf6a9bde8b055
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-Smooth_muscle_cells\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	KCND3 PDE5A LRP1B MOCS1	1.85e-04	175	72	4	fed9e4120c758fdcc23bb248d1801002b0e0d485
ToppCell	facs-Kidney-nan-24m-Epithelial-kidney_collecting_duct_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRYL1 PPP2R3A WDR81 TMEM106A	1.93e-04	177	72	4	2bf639e9e801e5144462ffc957f5739e0dfcd500
ToppCell	facs-Kidney-nan-24m-Epithelial-kidney_collecting_duct_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRYL1 PPP2R3A WDR81 TMEM106A	1.93e-04	177	72	4	9c7c6824b9011363851f084a500d665f025b026e
ToppCell	COVID-19-Heart-CM_3\|Heart / Disease (COVID-19 only), tissue and cell type	FNIP2 PPP2R3A CDIN1 FHOD3	2.15e-04	182	72	4	287fcc3897ae08841f6f85ae6c9cef16f75b1dd1
ToppCell	COVID-19-kidney-Distal_Epi_Doublet_(PCT)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PPP2R3A FHOD3 SIM1 LRP1B	2.15e-04	182	72	4	9d67717a6e13bcb54c1297a3e4e3abf4e51628a3
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCNT1 IPO7 NFKBIZ MAP4K4	2.29e-04	185	72	4	eb7d3c1363d5fedc611f9c1a91ea823de251355e
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CRYL1 ANK2 SIM1 LRP1B	2.38e-04	187	72	4	85e58a312fc325e4063a2d250666b99b8f99beb6
ToppCell	COVID-19-kidney\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PPP2R3A FHOD3 SIM1 LRP1B	2.38e-04	187	72	4	d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|World / Chamber and Cluster_Paper	PPP2R3A KCND3 CDIN1 FHOD3	2.38e-04	187	72	4	78cdcf8bc141d3b155c3c8af908431fc419c4d08
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MLKL DDX60 SNRK CTH	2.38e-04	187	72	4	f3397dbc23b6c2f24e2c1ba887d8f9aef3ee01a1
ToppCell	COVID-19-kidney-CD-PC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PPP2R3A FHOD3 SIM1 LRP1B	2.43e-04	188	72	4	8f9996c3f3b27efaaae8960a66af77412de9c7ef
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK2 SLC30A8 NFKBIZ PDE5A	2.43e-04	188	72	4	a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCell	COVID-19-kidney-DCT\|kidney / Disease (COVID-19 only), tissue and cell type	TRPM6 FHOD3 SIM1 LRP1B	2.43e-04	188	72	4	df1fd0819d301679f3c9ea404e942e39095912eb
ToppCell	facs-Pancreas-Endocrine-24m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK2 SLC30A8 NFKBIZ PDE5A	2.48e-04	189	72	4	010fdd70e9d0e21b856306a29ff877776a480319
ToppCell	cellseq2-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-VEC\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MLKL SNX25 WDR81 ZNF461	2.48e-04	189	72	4	bccb3481ffed597c845fe860da658505316105b5
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	FNIP2 ANK2 CDIN1 FHOD3	2.48e-04	189	72	4	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TRPM6 FHOD3 SIM1 LRP1B	2.48e-04	189	72	4	90aae7e806882bebfad78a78e9a16cf56af3ecd4
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|RV / Chamber and Cluster_Paper	FNIP2 ANK2 CDIN1 FHOD3	2.53e-04	190	72	4	93c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TRPM6 FHOD3 SIM1 LRP1B	2.53e-04	190	72	4	4836ea19308d2a96694f12ab0653b7ce7b101d2f
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	ANK2 KCND3 CDIN1 FHOD3	2.53e-04	190	72	4	de5ef606a002f85c2e0e3a36c1f259d0b85a76ff
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK2 SLC30A8 NFKBIZ PDE5A	2.58e-04	191	72	4	a251b134f67a0a1ef3a42f50042f128a17f20b22
ToppCell	LA-03._Atrial_Cardiomyocyte\|LA / Chamber and Cluster_Paper	PPP2R3A ANK2 KCND3 FHOD3	2.58e-04	191	72	4	5d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK2 SLC30A8 NFKBIZ PDE5A	2.58e-04	191	72	4	3387b95a3f2445c672d407922fdce3a91eabaef8
ToppCell	COVID-19-kidney-CNT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PPP2R3A FHOD3 SIM1 LRP1B	2.64e-04	192	72	4	760c6b9628de9693034b00c5025c5c4df94bb2e8
ToppCell	H1299-infected\|H1299 / Cell line, Condition and Strain	CCNL2 ZKSCAN1 CCNL1 SLTM	2.64e-04	192	72	4	9cf8049bdc3e0f81ce69042beac72b08d8f38b4e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CRYL1 PPP2R3A FHOD3 LRP1B	2.69e-04	193	72	4	82e8a4c40299ffcdfd5a0da711bb9de6fb8a2eaa
ToppCell	RA-03._Atrial_Cardiomyocyte\|RA / Chamber and Cluster_Paper	PPP2R3A ANK2 KCND3 FHOD3	2.74e-04	194	72	4	c3535f7cc0076653c72db582047cff053c322397
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PPP2R3A FHOD3 SIM1 LRP1B	2.80e-04	195	72	4	6477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Epithelial-Epithelial,_Airway-secretory_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	FASTK MAB21L4 ZNF57 CDC42BPB	2.85e-04	196	72	4	547901c7a665770eff78eede69b8625b416c8186
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PPP2R3A ANK2 FHOD3 SIM1	2.85e-04	196	72	4	c7136b1c83bcf907eec3b02b151fa061298b6672
ToppCell	Mild/Remission\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	DDX60 CCNL1 NFKBIZ RICTOR	2.85e-04	196	72	4	71603a3b7df40eb3f267345f55e44a812fea7926
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	FASTK MAB21L4 ZNF57 CDC42BPB	2.85e-04	196	72	4	6e08d7ba67da161c2dca1a17c440ffb9d9b5bc3b
ToppCell	COVID-19_Mild\|World / Disease group, lineage and cell class	DDX60 CCNL1 NFKBIZ RICTOR	2.91e-04	197	72	4	5c33454b10023decd2f5ccda9229b6512659711e
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)	DDX60 CCNL1 NFKBIZ RICTOR	2.96e-04	198	72	4	44417089b62056269cac38d3134ff209c05b7007
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DDX60 CCNL1 NFKBIZ RICTOR	2.96e-04	198	72	4	28ef3fc4c17dcb765537b75917f7db78baa522db
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Newborn-35\|World / Primary Cells by Cluster	ANK2 ZKSCAN1 MAPK8 MAP4K4	2.96e-04	198	72	4	de5214a85fe017eb23d4aa8af624464f062ec57e
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RALGAPA1 CCNT1 CCNL1 RICTOR	3.02e-04	199	72	4	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	control-HLA-DR+_CD83+_Monocyte\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	NFKBIZ CLEC10A CDC42BPB TMEM106A	3.02e-04	199	72	4	f1b370d2869ad29c9d8ff41fdcc486fffa781ee2
ToppCell	Tracheal-NucSeq-Stromal-Chondrocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLC30A8 CTH LRP1B TAFA2	3.08e-04	200	72	4	b5a54b9baf79aea01f76a161f0a39bbe87eb4945
ToppCell	Tracheal-NucSeq-Stromal-Chondrocytic-Chondrocyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLC30A8 CTH LRP1B TAFA2	3.08e-04	200	72	4	f5bd0b30e478dac09f68c46b0781f5f2e7e3c693
Disease	Trigeminal Neuralgia	MAPK8 MAPK9	3.50e-04	12	69	2	C0040997
Disease	Secondary Trigeminal Neuralgia	MAPK8 MAPK9	3.50e-04	12	69	2	C0393787
Disease	Trigeminal Neuralgia, Idiopathic	MAPK8 MAPK9	3.50e-04	12	69	2	C0393786
Disease	gallbladder cancer (is_implicated_in)	RICTOR LRP1B	4.13e-04	13	69	2	DOID:3121 (is_implicated_in)
Disease	psoriasis, type 2 diabetes mellitus	TYK2 SLC30A8 NFKBIZ	7.33e-04	75	69	3	EFO_0000676, MONDO_0005148
Disease	Hereditary Non-Polyposis Colon Cancer Type 2	BARD1 NFKBIZ	8.98e-04	19	69	2	C1333991
Disease	Colorectal cancer, hereditary nonpolyposis, type 1	BARD1 NFKBIZ	8.98e-04	19	69	2	C2936783
Disease	Ovarian Serous Adenocarcinoma	SNRK MAP3K4	1.32e-03	23	69	2	C1335177
Disease	Brugada Syndrome (disorder)	ANK2 KCND3	1.44e-03	24	69	2	C1142166
Disease	Adenocarcinoma of large intestine	TYK2 MAPK9 CDC42BPB	1.50e-03	96	69	3	C1319315
Disease	Hereditary Nonpolyposis Colorectal Neoplasms	BARD1 NFKBIZ	1.69e-03	26	69	2	C0009405
Disease	Hereditary non-polyposis colorectal cancer syndrome	BARD1 NFKBIZ	1.82e-03	27	69	2	C1112155
Disease	indole-3-propionate measurement	KCND3 SLC30A8	1.82e-03	27	69	2	EFO_0010501
Disease	colorectal adenocarcinoma (is_marker_for)	RICTOR MAPK8	1.82e-03	27	69	2	DOID:0050861 (is_marker_for)
Disease	Hereditary Nonpolyposis Colorectal Cancer	BARD1 NFKBIZ	2.10e-03	29	69	2	C1333990

Protein segments in the cluster

Peptide	Gene	Start	Entry
EHVIKVAHACLHPLE	CCNT2	101	O60583
HEACNHGHLKVVELL	BARD1	466	Q99728
VIDIEGCAHIVHKHG	CTH	166	P32929
GCAHIVHKHGDIILV	CTH	171	P32929
LEHVIKVAHTCLHPQ	CCNT1	101	O60563
DHPHTHVVKCTQLVR	CCNT1	151	O60563
ELGFCVHVKHPHKII	CCNL1	191	Q9UK58
CKVKTEHEDGHILHA	CER1	241	O95813
QGDHVECVKHLLQHK	ANK2	341	Q01484
HTIHVCLHLAVLLGF	FASTK	156	Q14296
LVAAIVHCKHHSLIA	MAB21L4	156	Q08AI8
LCGIKHLHSAGIIHR	MAPK9	136	P45984
IHHVIHRDIKGQNVL	MAP4K4	146	O95819
GCLHDIQVHPIKNLH	KIF14	1201	Q15058
LIESQHHHLLHCLEK	KCND3	471	Q9UK17
LHCAVIAHNAVVHEL	NFKBIZ	556	Q9BYH8
HLKCSQVCEQHKHTV	LRP1B	1221	Q9NZR2
HCLHIIVHQFTKVSK	LZTR1	791	Q8N653
LEKHVCSIKHGDIHF	DDX60	986	Q8IY21
IRVQLTTCIHHIIKH	IPO7	106	O95373
LCGIKHLHSAGIIHR	MAPK8	136	P45983
TALCHKIFLHIHGLI	PDE5A	166	O76074
LRTINIKCHVHDPHG	FBXO39	251	Q8N4B4
KIVILLCGRNHHVHL	CDC42BPB	1291	Q9Y5S2
HIITLGQVIHKRCEE	MLKL	6	Q8NB16
VVHHSVCADLLHIPV	PPP2R3A	46	Q06190
LVHHKTGCHLLEVQN	RICTOR	886	Q6R327
SQLHHLSIKCAIHVL	PPFIBP2	676	Q8ND30
IPLCHHVALSHIQVQ	MOCS1	551	Q9NZB8
EKLLGDVLCLVHHHR	ITPRIPL1	276	Q6GPH6
LKHIDPVVLKHCHAA	COMMD3	51	Q9UBI1
CIKHAIGHEHEVLLR	CDIN1	156	Q9Y2V0
ELGFCVHVKHPHKII	CCNL2	186	Q96S94
KQCLVADLVHTVHHP	FNIP2	971	Q9P278
VLHIVVVGFHHKKGC	AVL9	16	Q8NBF6
VKDTVHKQSLLHHVC	FHOD3	1116	Q2V2M9
ELCAHHVTIVAHLIK	C1orf112	471	Q9NSG2
HYICKLATHAIHLVV	FKTN	161	O75072
QHHVGTLRHKQAVCA	CDC20B	346	Q86Y33
LFAGLVHVKQCIVAH	CRYL1	131	Q9Y2S2
CQHLIHSLNHIKEIP	POLI	251	Q9UNA4
HICTVVNFKELAEHH	FAM120B	16	Q96EK7
QKLVLDVAHVHEHCC	AFP	256	P02771
INVLHEHGIVHRDIK	MAP3K4	1451	Q9Y6R4
LEIKVHHVLLHIQGT	TMEM106A	211	Q96A25
AHHVKTGTCEVVALH	TAFA2	36	Q8N3H0
LHHRLSHVDVVKVVC	SNX25	46	Q9H3E2
CIAHLHRTELHGQLI	SLTM	441	Q9NWH9
HLRCAHHLLLVKGQV	SIM1	276	P81133
AQIVHAISYCHKLHV	SNRK	121	Q9NRH2
LGHQVVLKDEVAHHQ	CCDC146	221	Q8IYE0
HILHHVNIGLKVKQC	ASCC3	1161	Q8N3C0
ELQEHTTQKAHLGHC	CLEC10A	121	Q8IUN9
HHVRHCVLNELAQLG	TOR2A	266	Q5JU69
VLTVVLHQRCLGHNH	SLC30A8	191	Q8IWU4
HIQIHTGIKPHKCTE	ZNF562	306	Q6V9R5
LVHKEVHTGIRYHIC	ZNF436	126	Q9C0F3
DLHSHVVNEHACKLI	ZNF639	331	Q9UID6
VHQRIHTGEKLHECS	ZNF268	321	Q14587
IIHTRTHTGEKLHEC	ZNF268	516	Q14587
HHLVQDVKQHTLLSG	TRPM6	491	Q9BX84
ICEELVHESHHPQIK	RALGAPA1	1301	Q6GYQ0
TENKILGVHCLHHIV	TTI2	261	Q6NXR4
HVCFTKGELQKHLHI	ZNF518A	241	Q6AHZ1
QKAHLIAHQIIHTGE	ZNF585A	421	Q6P3V2
IAHQIIHTGEKPHKC	ZNF585A	426	Q6P3V2
LTHTVVKLKCQHCNH	ZMYM6	421	O95789
HKIIHIGIHTEETVQ	ZNF493	631	Q6ZR52
IHTQEQLHKCEHCGK	ZNF57	441	Q68EA5
VLHQRIHTGEKPHEC	ZKSCAN1	421	P17029
VHEDTHKVHLLCLLA	XPC	201	Q01831
VIHHEVKEIGTHILV	TRAPPC13	131	A5PLN9
EKNVCLHLVDAHTHL	WDR81	561	Q562E7
LIHHQAIHGCRETLQ	ZNF816	636	Q0VGE8
VHCSQLKHLRIHNGE	ZNF461	256	Q8TAF7
KHCLTIHQRIHTGEK	ZNF311	511	Q5JNZ3
LTAEEVCIHIAHKVG	TYK2	51	P29597