Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR8U1 GALR1 OR4N5 OR4N4 OR2T7 OR2L5 GCGR GPR162 TAAR6 OR8U9 OR8U8 GPR83 GIPR ADORA3 OR6A2 P2RY6 ADGRA1 ADGRD1 GABBR1	5.14e-07	884	113	19	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	SELE OR8U1 GALR1 OR4N5 OR4N4 OR2T7 OR2L5 GCGR GPR162 TAAR6 OR8U9 OR8U8 IFNGR2 GPR83 GIPR ADORA3 OR6A2 P2RY6 PKD1 ADGRA1 ADGRD1 GABBR1	6.09e-06	1353	113	22	GO:0004888
GeneOntologyMolecularFunction	superoxide-generating NADPH oxidase activity	NOX5 NOX1	1.89e-04	4	113	2	GO:0106292
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR8U1 GALR1 OR4N5 OR4N4 OR2T7 OR2L5 GCGR GPR162 TAAR6 OR8U9 OR8U8 GPR83 GIPR ADORA3 OR6A2 P2RY6 PRKCA ADGRA1 GNAT1 ADGRD1 GABBR1 RAPGEFL1	5.10e-06	1395	112	22	GO:0007186
GeneOntologyBiologicalProcess	negative regulation of type I interferon production	CYLD GBP6 XAF1 SIGLEC1 NLRC3	1.10e-05	54	112	5	GO:0032480
Domain	Ferric_reduct	NOX5 NOX1 STEAP3	4.56e-05	12	113	3	PF01794
Domain	Fe3_Rdtase_TM_dom	NOX5 NOX1 STEAP3	4.56e-05	12	113	3	IPR013130
Domain	GPCR_2_secretin-like_CS	GCGR GIPR ADGRA1 ADGRD1	5.12e-05	34	113	4	IPR017983
Domain	GPCR_Rhodpsn_7TM	OR8U1 GALR1 OR4N5 OR4N4 OR2L5 GPR162 TAAR6 OR8U9 OR8U8 GPR83 ADORA3 OR6A2 P2RY6	2.06e-04	670	113	13	IPR017452
Domain	7tm_1	OR8U1 GALR1 OR4N5 OR4N4 OR2L5 GPR162 TAAR6 OR8U9 OR8U8 GPR83 ADORA3 OR6A2 P2RY6	2.28e-04	677	113	13	PF00001
Domain	7tm_2	GCGR GIPR ADGRA1 ADGRD1	2.36e-04	50	113	4	PF00002
Domain	G_PROTEIN_RECEP_F2_2	GCGR GIPR ADGRA1 ADGRD1	2.36e-04	50	113	4	PS00650
Domain	G_PROTEIN_RECEP_F1_1	OR8U1 GALR1 OR4N5 OR4N4 OR2L5 GPR162 TAAR6 OR8U9 OR8U8 GPR83 ADORA3 OR6A2 P2RY6	2.56e-04	685	113	13	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR8U1 GALR1 OR4N5 OR4N4 OR2L5 GPR162 TAAR6 OR8U9 OR8U8 GPR83 ADORA3 OR6A2 P2RY6	2.78e-04	691	113	13	PS50262
Domain	GPCR_Rhodpsn	OR8U1 GALR1 OR4N5 OR4N4 OR2L5 GPR162 TAAR6 OR8U9 OR8U8 GPR83 ADORA3 OR6A2 P2RY6	2.82e-04	692	113	13	IPR000276
Domain	GPCR_2_secretin-like	GCGR GIPR ADGRA1 ADGRD1	4.77e-04	60	113	4	IPR000832
Domain	GPCR_2-like	GCGR GIPR ADGRA1 ADGRD1	4.77e-04	60	113	4	IPR017981
Domain	G_PROTEIN_RECEP_F2_4	GCGR GIPR ADGRA1 ADGRD1	5.08e-04	61	113	4	PS50261
Domain	DCX	DCLK2 DCLK1	5.36e-04	6	113	2	SM00537
Domain	-	DCLK2 DCLK1	7.47e-04	7	113	2	3.10.20.230
Domain	DCX	DCLK2 DCLK1	7.47e-04	7	113	2	PF03607
Domain	NAD_binding_6	NOX5 NOX1	7.47e-04	7	113	2	PF08030
Domain	FAD_binding_8	NOX5 NOX1	7.47e-04	7	113	2	PF08022
Domain	FAD-bd_8	NOX5 NOX1	7.47e-04	7	113	2	IPR013112
Domain	Fe_red_NAD-bd_6	NOX5 NOX1	7.47e-04	7	113	2	IPR013121
Domain	DC	DCLK2 DCLK1	9.92e-04	8	113	2	PS50309
Domain	Doublecortin_dom	DCLK2 DCLK1	9.92e-04	8	113	2	IPR003533
Domain	ARM-like	RANGAP1 DOCK8 FRYL VAC14 LRBA HEATR5B AP3D1	1.28e-03	270	113	7	IPR011989
Pathway	WP_GPCRS_OTHER	OR8U1 GPR162 GPR83 ADORA3 OR6A2 GABBR1	3.56e-05	96	91	6	MM15939
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FRAS1 MED14 FRYL SFI1 TMEM127 TUBG1 MADD BAP1 VAC14 NISCH PKD1 STEAP3 ZFYVE26 LRBA SIPA1L2 TOP3B AP3D1 PLK3 ARAP1	5.42e-09	1105	117	19	35748872
Pubmed	An evolutionarily conserved nested gene pair - Mab21 and Lrba/Nbea in metazoan.	DCLK2 LRBA DCLK1	7.37e-07	6	117	3	19482073
Pubmed	Lhx2-dependent specification of olfactory sensory neurons is required for successful integration of olfactory, vomeronasal, and GnRH neurons.	RELN LHX2 TH	4.38e-06	10	117	3	22581782
Pubmed	TGF-β1 protects colon tumor cells from apoptosis through XAF1 suppression.	TGFB1 XAF1	1.12e-05	2	117	2	31081052
Pubmed	TGF-beta signaling in dendritic cells is a prerequisite for the control of autoimmune encephalomyelitis.	RAG1 TGFB1	1.12e-05	2	117	2	18669656
Pubmed	Pathogenic mutations of TGFBI and CHST6 genes in Chinese patients with Avellino, lattice, and macular corneal dystrophies.	CHST6 TGFB1	1.12e-05	2	117	2	21887843
Pubmed	Regulation of NADPH oxidase 5 by protein kinase C isoforms.	NOX5 PRKCA	1.12e-05	2	117	2	24505490
Pubmed	The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein.	PKD1 PKHD1	1.12e-05	2	117	2	11919560
Pubmed	Erythrocyte NADPH oxidase activity modulated by Rac GTPases, PKC, and plasma cytokines contributes to oxidative stress in sickle cell disease.	NOX1 PRKCA	1.12e-05	2	117	2	23349388
Pubmed	Evidence of distinct RELN and TGFB1 genetic associations in familial and non-familial otosclerosis in a British population.	RELN TGFB1	1.12e-05	2	117	2	29728750
Pubmed	Doublecortin-like kinase enhances dendritic remodelling and negatively regulates synapse maturation.	DCLK2 DCLK1	1.12e-05	2	117	2	23385585
Pubmed	Disruption of TGF-β signaling improves ocular surface epithelial disease in experimental autoimmune keratoconjunctivitis sicca.	RAG1 TGFB1	1.12e-05	2	117	2	22194977
Pubmed	OX40 ligand regulates inflammation and mortality in the innate immune response to sepsis.	RAG1 TNFSF4	1.12e-05	2	117	2	20844189
Pubmed	Transforming growth factor beta 1 up-regulates CD169 (sialoadhesin) expression on monocyte-derived dendritic cells: role in HIV sexual transmission.	TGFB1 SIGLEC1	1.12e-05	2	117	2	25354152
Pubmed	Pathogenicity analysis of novel variations in Chinese Han patients with polycystic kidney disease.	PKD1 PKHD1	1.12e-05	2	117	2	28578020
Pubmed	Role of NOX1 and NOX5 in protein kinase C/reactive oxygen species‑mediated MMP‑9 activation and invasion in MCF‑7 breast cancer cells.	NOX5 NOX1	1.12e-05	2	117	2	39219290
Pubmed	Induction of Siglec-1 by Endotoxin Tolerance Suppresses the Innate Immune Response by Promoting TGF-β1 Production.	TGFB1 SIGLEC1	1.12e-05	2	117	2	27129263
Pubmed	Genetic association analysis in a clinically and histologically confirmed otosclerosis population confirms association with the TGFB1 gene but suggests an association of the RELN gene with a clinically indistinguishable otosclerosis-like phenotype.	RELN TGFB1	1.12e-05	2	117	2	24643032
Pubmed	CHI3L1 promotes tumor progression by activating TGF-β signaling pathway in hepatocellular carcinoma.	CHI3L1 TGFB1	1.12e-05	2	117	2	30301907
Pubmed	Up-regulation of acyl-coenzyme A:cholesterol acyltransferase-1 by transforming growth factor-beta1 during differentiation of human monocytes into macrophages.	TGFB1 SOAT1	1.12e-05	2	117	2	15219857
Pubmed	The Innate Immune Sensor NLRC3 Acts as a Rheostat that Fine-Tunes T Cell Responses in Infection and Autoimmunity.	RAG1 NLRC3	1.12e-05	2	117	2	30566882
Pubmed	Murine LRBA deficiency causes CTLA-4 deficiency in Tregs without progression to immune dysregulation.	RAG1 LRBA	1.12e-05	2	117	2	28611475
Pubmed	DPP-4 inhibition contributes to the prevention of hypoglycaemia through a GIP-glucagon counterregulatory axis in mice.	GCGR GIPR	1.12e-05	2	117	2	25660260
Pubmed	Paradoxical dampening of anti-islet self-reactivity but promotion of diabetes by OX40 ligand.	RAG1 TNFSF4	1.12e-05	2	117	2	14662903
Pubmed	The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation.	FRAS1 TSHZ2 TGFB1 PKD1 PKHD1	1.80e-05	95	117	5	20843830
Pubmed	Expression of LIM-homeodomain transcription factors in the developing and mature mouse retina.	LHX2 TH PRKCA	2.01e-05	16	117	3	24333658
Pubmed	A Pkd1-Fbn1 genetic interaction implicates TGF-β signaling in the pathogenesis of vascular complications in autosomal dominant polycystic kidney disease.	TGFB1 PKD1	3.36e-05	3	117	2	24071006
Pubmed	Characterization of PKD protein-positive exosome-like vesicles.	PKD1 PKHD1	3.36e-05	3	117	2	19158352
Pubmed	Dipeptidyl peptidase 4 (DPP-4) is expressed in mouse and human islets and its activity is decreased in human islets from individuals with type 2 diabetes.	GCGR GIPR	3.36e-05	3	117	2	24939431
Pubmed	T cell surveillance of oncogene-induced prostate cancer is impeded by T cell-derived TGF-β1 cytokine.	RAG1 TGFB1	3.36e-05	3	117	2	21757379
Pubmed	T cell requirement for development of chronic ulcerative dermatitis in E- and P-selectin-deficient mice.	SELE RAG1	3.36e-05	3	117	2	12391189
Pubmed	Dual elimination of the glucagon and GLP-1 receptors in mice reveals plasticity in the incretin axis.	GCGR GIPR	3.36e-05	3	117	2	21540554
Pubmed	Rod Photoreceptors Signal Fast Changes in Daylight Levels Using a Cx36-Independent Retinal Pathway in Mouse.	GJD2 GNAT1	3.36e-05	3	117	2	31776212
Pubmed	PARP-1 regulates expression of TGF-β receptors in T cells.	RAG1 TGFB1	3.36e-05	3	117	2	23940283
Pubmed	Anti-carcinogenic action of ellagic acid mediated via modulation of oxidative stress regulated genes in Dalton lymphoma bearing mice.	TGFB1 PRKCA	3.36e-05	3	117	2	21756219
Pubmed	Inducible and myocyte-specific inhibition of PKCalpha enhances cardiac contractility and protects against infarction-induced heart failure.	ADORA3 PRKCA	3.36e-05	3	117	2	17921332
Pubmed	CYLD negatively regulates transforming growth factor-β-signalling via deubiquitinating Akt.	CYLD TGFB1	3.36e-05	3	117	2	22491319
Pubmed	Reelin signaling modulates GABAB receptor function in the neocortex.	RELN GABBR1	3.36e-05	3	117	2	32083308
Pubmed	Motor coordination and synaptic plasticity deficits are associated with increased cerebellar activity of NADPH oxidase, CAMKII, and PKC at preplaque stage in the TgCRND8 mouse model of Alzheimer's disease.	NOX1 PRKCA	3.36e-05	3	117	2	29602494
Pubmed	Analysis of the polycystin complex (PCC) in human urinary exosome-like vesicles (ELVs).	PKD1 PKHD1	3.36e-05	3	117	2	32001768
Pubmed	DOCK8 regulates protective immunity by controlling the function and survival of RORγt+ ILCs.	RAG1 DOCK8	3.36e-05	3	117	2	25091235
Pubmed	Expression of polycystins and fibrocystin on primary cilia of lung cells.	PKD1 PKHD1	3.36e-05	3	117	2	25367197
Pubmed	Direct rod input to cone BCs and direct cone input to rod BCs challenge the traditional view of mammalian BC circuitry.	GJD2 GNAT1	3.36e-05	3	117	2	20018684
Pubmed	Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms.	DCLK2 DCLK1	3.36e-05	3	117	2	26526391
Pubmed	GSK-3beta regulates proper mitotic spindle formation in cooperation with a component of the gamma-tubulin ring complex, GCP5.	TUBGCP5 TUBG1	3.36e-05	3	117	2	18316369
Pubmed	The deubiquitinase CYLD targets Smad7 protein to regulate transforming growth factor β (TGF-β) signaling and the development of regulatory T cells.	CYLD TGFB1	3.36e-05	3	117	2	21931165
Pubmed	Opposing effects of TGF-beta and IL-15 cytokines control the number of short-lived effector CD8+ T cells.	RAG1 TGFB1	3.36e-05	3	117	2	19604492
Pubmed	IFNγ-Induced MHC Class II Expression on Islet Endothelial Cells Is an Early Marker of Insulitis but Is Not Required for Diabetogenic CD4+ T Cell Migration.	RAG1 IFNGR2	3.36e-05	3	117	2	30555479
Pubmed	The P2Y6 receptor signals through Gαq /Ca2+ /PKCα and Gα13 /ROCK pathways to drive the formation of membrane protrusions and dictate cell migration.	P2RY6 PRKCA	3.36e-05	3	117	2	32420639
Pubmed	Fibrocystin/Polyductin releases a C-terminal fragment that translocates into mitochondria and suppresses cystogenesis.	PKD1 PKHD1	3.36e-05	3	117	2	37845212
Pubmed	Alternative transcripts of Dclk1 and Dclk2 and their expression in doublecortin knockout mice.	DCLK2 DCLK1	3.36e-05	3	117	2	18075264
Pubmed	Reelin is involved in transforming growth factor-β1-induced cell migration in esophageal carcinoma cells.	RELN TGFB1	3.36e-05	3	117	2	22393371
Pubmed	Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.	GCGR TAAR6 GIPR ADORA3 P2RY6 GNAT1	6.18e-05	200	117	6	18240029
Pubmed	DOT1L promotes progenitor proliferation and primes neuronal layer identity in the developing cerebral cortex.	RELN TUBG1 LHX2	6.26e-05	23	117	3	30329130
Pubmed	TGF-β and NF-κB signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers.	NR2C2 TGFB1	6.70e-05	4	117	2	22641218
Pubmed	Protein kinase Cα suppresses Kras-mediated lung tumor formation through activation of a p38 MAPK-TGFβ signaling axis.	TGFB1 PRKCA	6.70e-05	4	117	2	23604119
Pubmed	A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents.	GCGR GIPR	6.70e-05	4	117	2	25485909
Pubmed	The X-linked intellectual disability gene product and E3 ubiquitin ligase KLHL15 degrades doublecortin proteins to constrain neuronal dendritogenesis.	DCLK2 DCLK1	6.70e-05	4	117	2	33199366
Pubmed	Type I IFN-dependent T cell activation is mediated by IFN-dependent dendritic cell OX40 ligand expression and is independent of T cell IFNR expression.	RAG1 TNFSF4	6.70e-05	4	117	2	22156349
Pubmed	CENPV Is a CYLD-Interacting Molecule Regulating Ciliary Acetylated α-Tubulin.	CYLD TUBG1	6.70e-05	4	117	2	31260673
Pubmed	CRISPR/Cas9-mediated knockout of p22phox leads to loss of Nox1 and Nox4, but not Nox5 activity.	NOX5 NOX1	6.70e-05	4	117	2	27614387
Pubmed	Cilia and polycystic kidney disease.	PKD1 PKHD1	6.70e-05	4	117	2	32475690
Pubmed	Regulation of vascular smooth muscle cell calcification by syndecan-4/FGF-2/PKCα signalling and cross-talk with TGFβ.	TGFB1 PRKCA	6.70e-05	4	117	2	29016732
Pubmed	Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells.	RAG1 TNFSF4	6.70e-05	4	117	2	14608036
Pubmed	OX40 costimulation turns off Foxp3+ Tregs.	RAG1 TNFSF4	6.70e-05	4	117	2	17575071
Pubmed	Loss of oriented cell division does not initiate cyst formation.	PKD1 PKHD1	6.70e-05	4	117	2	19959710
Pubmed	Different functions of HOPS isoforms in the cell: HOPS shuttling isoform is determined by RIP cleavage system.	RANGAP1 TUBG1	6.70e-05	4	117	2	24240191
Pubmed	Amplification of the inflammatory cellular redox state by human immunodeficiency virus type 1-immunosuppressive tat and gp160 proteins.	NOX5 NOX1	6.70e-05	4	117	2	9882350
Pubmed	Tissue-intrinsic dysfunction of circadian clock confers transplant arteriosclerosis.	RAG1 PER3	6.70e-05	4	117	2	21969583
Pubmed	Progranulin prevents regulatory NK cell cytotoxicity against antiviral T cells.	RAG1 SIGLEC1	6.70e-05	4	117	2	31484831
Pubmed	Cellular and molecular events in the localization of diabetogenic T cells to islets of Langerhans.	RAG1 IFNGR2	6.70e-05	4	117	2	21220322
Pubmed	TTRAP is a novel component of the non-canonical TRAF6-TAK1 TGF-β signaling pathway.	NR2C2 TGFB1	6.70e-05	4	117	2	21980489
Pubmed	Lack of Reelin causes malpositioning of nigral dopaminergic neurons: evidence from comparison of normal and Reln(rl) mutant mice.	RELN TH	6.70e-05	4	117	2	12724835
Pubmed	TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction.	RELN TSHZ2 TH	7.13e-05	24	117	3	24487590
Pubmed	Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.	GPR83 PKD1 PKHD1	8.08e-05	25	117	3	28154160
Pubmed	A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation.	PKD1 PKHD1	1.11e-04	5	117	2	21685914
Pubmed	Breast cancer-derived factors stimulate osteoclastogenesis through the Ca2+/protein kinase C and transforming growth factor-beta/MAPK signaling pathways.	TGFB1 PRKCA	1.11e-04	5	117	2	19801662
Pubmed	Intestinal CD169(+) macrophages initiate mucosal inflammation by secreting CCL8 that recruits inflammatory monocytes.	RAG1 SIGLEC1	1.11e-04	5	117	2	26193821
Pubmed	Differential expression of LIM-homeodomain factors in Cajal-Retzius cells of primates, rodents, and birds.	RELN LHX2	1.11e-04	5	117	2	19923199
Pubmed	High-glucose-increased expression and activation of NADPH oxidase in human vascular smooth muscle cells is mediated by 4-hydroxynonenal-activated PPARα and PPARβ/δ.	NOX5 NOX1	1.11e-04	5	117	2	25722086
Pubmed	Heligmosomoides polygyrus bakeri Infection Decreases Smad7 Expression in Intestinal CD4+ T Cells, Which Allows TGF-β to Induce IL-10-Producing Regulatory T Cells That Block Colitis.	RAG1 TGFB1	1.11e-04	5	117	2	30850474
Pubmed	Antioxidants and NOX1/NOX4 inhibition blocks TGFβ1-induced CCN2 and α-SMA expression in dermal and gingival fibroblasts.	TGFB1 NOX1	1.11e-04	5	117	2	29049376
Pubmed	Comparison of OX40 ligand and CD70 in the promotion of CD4+ T cell responses.	RAG1 TNFSF4	1.11e-04	5	117	2	20639485
Pubmed	ADAM9 enhances Th17 cell differentiation and autoimmunity by activating TGF-β1.	RAG1 TGFB1	1.11e-04	5	117	2	33911034
Pubmed	DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8⁺ T cells independently of PD-1 and PD-L1.	RAG1 LY75	1.11e-04	5	117	2	24021877
Pubmed	Melanoma upregulates ICAM-1 expression on endothelial cells through engagement of tumor CD44 with endothelial E-selectin and activation of a PKCα-p38-SP-1 pathway.	SELE PRKCA	1.11e-04	5	117	2	25138157
Pubmed	A case-control investigation of immune function gene polymorphisms and risk of testicular germ cell tumors.	TGFB1 IFNGR2	1.11e-04	5	117	2	17220333
Pubmed	Primary cilia control telencephalic patterning and morphogenesis via Gli3 proteolytic processing.	TUBG1 LHX2 TH	1.14e-04	28	117	3	21490064
Pubmed	Necessity and Sufficiency of Ldb1 in the Generation, Differentiation and Maintenance of Non-photoreceptor Cell Types During Retinal Development.	LHX2 TH PRKCA	1.41e-04	30	117	3	30127719
Pubmed	Loss of polycystin-1 inhibits Bicc1 expression during mouse development.	PKD1 PKHD1	1.67e-04	6	117	2	24594709
Pubmed	TGF-β cytokine signaling promotes CD8+ T cell development and low-affinity CD4+ T cell homeostasis by regulation of interleukin-7 receptor α expression.	RAG1 TGFB1	1.67e-04	6	117	2	23932572
Pubmed	Selectin-deficiency reduces the number of spontaneous metastases in a xenograft model of human breast cancer.	SELE RAG1	1.67e-04	6	117	2	22366582
Pubmed	Molecular identification and characterization of a family of kinases with homology to Ca2+/calmodulin-dependent protein kinases I/IV.	DCLK2 DCLK1	1.67e-04	6	117	2	16684769
Pubmed	Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway.	PKD1 PKHD1	1.67e-04	6	117	2	17575307
Pubmed	Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation.	RAG1 TGFB1	1.67e-04	6	117	2	21435587
Pubmed	TGF-β signalling is required for CD4⁺ T cell homeostasis but dispensable for regulatory T cell function.	RAG1 TGFB1	1.67e-04	6	117	2	24115907
Pubmed	ApoER2 and VLDLr are required for mediating reelin signalling pathway for normal migration and positioning of mesencephalic dopaminergic neurons.	RELN TH	1.67e-04	6	117	2	23976984
Pubmed	Entry of diabetogenic T cells into islets induces changes that lead to amplification of the cellular response.	RAG1 IFNGR2	1.67e-04	6	117	2	21220309
Pubmed	Interferon-γ Limits Diabetogenic CD8+ T-Cell Effector Responses in Type 1 Diabetes.	RAG1 IFNGR2	1.67e-04	6	117	2	27920091
Pubmed	The COMPASS Family Protein ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling.	RELN DCLK2 DCLK1	1.71e-04	32	117	3	31315048
Cytoband	21q22.11	BACH1 IFNGR2 EVA1C KRTAP24-1	1.99e-05	62	117	4	21q22.11
GeneFamily	Glucagon receptor family	GCGR GIPR	2.87e-04	6	80	2	269
GeneFamily	Doublecortin superfamily	DCLK2 DCLK1	8.50e-04	10	80	2	1369
GeneFamily	Olfactory receptors, family 8	OR8U1 OR8U9 OR8U8	1.33e-03	49	80	3	155
CoexpressionAtlas	adrenal gland	GJD2 GALR1 GCGR GPR83 TH TMEM130 SLC47A1 ADGRA1 SOAT1 KCNH5	4.14e-07	247	105	10	adrenal gland
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ANO9 FRAS1 TSHZ2 FRYL SFI1 TUBGCP5 GIPR LRBA	3.45e-08	193	113	8	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CYLD ANO9 FRAS1 TSHZ2 FRYL TUBGCP5 LRBA	7.24e-07	197	113	7	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 GJD2 GCGR FRYL GIPR PRKCA	5.51e-06	174	113	6	f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK8 EVA1C ADGRA1 DCLK2 VWA5B1 KCNH5	6.68e-06	180	113	6	cfc8bfbfd3617aabbb49f9730c29b673ca157e74
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RELN TSHZ2 EVA1C TMEM130 ERP27 SIPA1L2	7.82e-06	185	113	6	34fcfd635c828dad9643bbf1c908d79282d6f5d9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RELN TSHZ2 EVA1C TMEM130 ERP27 SIPA1L2	7.82e-06	185	113	6	8816f2909ed11833ff3d0ed96b9cb6d6fe9e1578
ToppCell	P03-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SELE TSHZ2 EVA1C NOX1 P2RY6 CRISPLD1	8.57e-06	188	113	6	5eb107122064f0a99dfd445cc87d3766f7257216
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RELN TSHZ2 EVA1C TMEM130 ERP27 SIPA1L2	8.57e-06	188	113	6	b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RELN TSHZ2 EVA1C TMEM130 ERP27 SIPA1L2	8.57e-06	188	113	6	874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN GJD2 MADD PER3 NISCH PRKCA	8.57e-06	188	113	6	a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GJD2 GALR1 MADD GIPR ADORA3 PRKCA	9.66e-06	192	113	6	5b7093d5af5ae7b0e6d3a464cc56272440ecedad
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RELN TSHZ2 CHI3L1 TMEM130 ERP27 SIPA1L2	1.02e-05	194	113	6	1374600957c7d7f0b05fd2c1186f521b9096d4ef
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN FRYL MADD GIPR NISCH PRKCA	1.06e-05	195	113	6	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RELN TSHZ2 CHI3L1 TMEM130 ERP27 SIPA1L2	1.09e-05	196	113	6	023477a499a2c190f363cfdbc9d9c646733a6541
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RELN TSHZ2 CHI3L1 TMEM130 ERP27 SIPA1L2	1.09e-05	196	113	6	3cb74f1a333a82cac2b459f2f1517e2acf22b5fd
ToppCell	Biopsy_Control_(H.)-Mesenchymal-Mesothelial_cells\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	GALR1 ATP10B CPZ CHI3L1 DCLK1 KCNH5	1.18e-05	199	113	6	ca970114b5aef4518ce580897a62ac88688b2671
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_12\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	KNTC1 GJD2 CDC45 ADORA3 DCLK2	1.28e-05	118	113	5	f0f40a0165156e3fc1584480b473b0e84e10d2cc
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_12\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	KNTC1 GJD2 CDC45 ADORA3 DCLK2	1.33e-05	119	113	5	a6b359e7aafcc197f53eb5e19c3a905bc09497bb
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Fezf2-Excitatory_Neuron.Slc17a7-Slc17a8.Fezf2-Slc17a8_(Layer_5,_Retrosplenial_cortex_(RSG)_and_Subiculum,_Tshz2+)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	DNAH3 ZP2 SIGLEC1 VWA5B1	3.40e-05	72	113	4	e3f4d1df43cc41b0424f27485a00ddca9e905f95
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR83 TH TMEM130 KRTAP24-1 RAPGEFL1	6.55e-05	166	113	5	548d0d6c0ffd564036ddba78620734220ebb73d7
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR83 TH TMEM130 KRTAP24-1 RAPGEFL1	6.55e-05	166	113	5	80e164a89d22098cabe4a99a78283ba69ea0561e
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-DN_to_DP_transition,_dividing_(more_DN)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DYNC2I2 ZNF184 LHX2 P2RY6 FGD1	6.93e-05	168	113	5	b9db0b1e4fe54a1fe79530d15d206155a1bfac39
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TSHZ2 TGFB1 LHX2 NOX1 CRISPLD1	7.33e-05	170	113	5	af8b56555cbd5a1016ab9ec2ce88225c58c89648
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L3_VIP_CBLN1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN TSHZ2 GPR83 SLC47A1 LOXL3	8.18e-05	174	113	5	93a0dd37d648fcb29654be70f631eee2915f682e
ToppCell	Thalamus-Neuronal-Excitatory\|Thalamus / BrainAtlas - Mouse McCarroll V32	NR2C2 RANGAP1 LHX2 DCLK2 KCNH5	8.63e-05	176	113	5	d2bbf13d21fb7582d7e5f90cd61a4ebe1cfccd66
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK8 UMODL1 PRKCA SIPA1L2 VWA5B1	8.63e-05	176	113	5	c2c4306476989bc2fb30dab00250ef7915842f13
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ANO9 TSHZ2 SFI1 CHI3L1 PRKCA	8.87e-05	177	113	5	64b8f665fdaf975558af2ad7d9b54d206de8350c
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN GBP6 NOX5 ZP2 KLHL14	8.87e-05	177	113	5	6248c0dcad302de61a66163ee84b3b79096150d7
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 GJD2 GALR1 GCGR GIPR	9.10e-05	178	113	5	fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH3 DYNC2I2 CHST6 GIPR WDR97	9.10e-05	178	113	5	3b12db04006db6e94fc45649a4b3a63b92f21a61
ToppCell	COVID-19-kidney-Epi_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	RELN TSHZ2 EVA1C TMEM130 SIPA1L2	9.35e-05	179	113	5	e7c9dc63f03d3f3746b51a7e3c8393089e2ceb7d
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TSHZ2 CHI3L1 LHX2 ADGRD1 KCNH5	9.35e-05	179	113	5	d3d3a9afaac28fa4f2c448c73d79bcbbbea088d7
ToppCell	facs-SCAT\|facs / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GBP6 CPZ XAF1 CRISPLD1 ADGRD1	9.60e-05	180	113	5	6c70b6b7480507fa94625013222ad338ee7dd1d9
ToppCell	Healthy_Control-Lymphoid-T-\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	KNTC1 DYNC2I2 LHX2 CCNE2 DCLK1	9.85e-05	181	113	5	ac1ee313910c05b1b3cb497bae14565464919c21
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RELN GJD2 RRAGB SEMA4G TMEM130	1.01e-04	182	113	5	f2a1784ffcba9b27132e0db21e574cbd8a0a6418
ToppCell	Globus_pallidus-Neuronal-Inhibitory\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	GJD2 TMEM127 SEMA4G TMEM130 ADGRA1	1.01e-04	182	113	5	04ccfa951eaa31fed6d140edb6c702d49363c5fa
ToppCell	Control-Epithelial_cells-Airway_mucous\|Control / group, cell type (main and fine annotations)	TSHZ2 ATP10B NOX1 PRKCA SIPA1L2	1.04e-04	183	113	5	15d24a4fb1ffe6cbafbd54fcd7dde9ddcfbe03b2
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	KNTC1 DOCK8 FRYL SFI1 LRBA	1.09e-04	185	113	5	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RELN GJD2 RRAGB SEMA4G TMEM130	1.09e-04	185	113	5	739260f8abebaf10a5cc49d91726278579e26170
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	KNTC1 DOCK8 FRYL SFI1 LRBA	1.12e-04	186	113	5	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	wk_20-22-Hematologic-Myeloid-Myelocyte-like\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	CYLD CHI3L1 LY75 NLRC3 VSTM1	1.12e-04	186	113	5	53b4ce33ae6fa32f1b56cbc62b1d7915e935afc9
ToppCell	facs-Pancreas-Endocrine-24m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN GJD2 MADD PER3 PRKCA	1.21e-04	189	113	5	010fdd70e9d0e21b856306a29ff877776a480319
ToppCell	P07-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TSHZ2 EVA1C NOX1 P2RY6 CRISPLD1	1.24e-04	190	113	5	e1b721bb74561fe51c53328a0394c9954e489049
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig-C\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ANO9 SERPINE3 GIPR ERP27 NLRC3	1.27e-04	191	113	5	95ae42d145adb478d886a2259baacc713cd6587b
ToppCell	facs-Aorta-Heart-3m-Mesenchymal-fibroblast\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 LOXL3 DCLK1 ADGRD1 ARAP1	1.27e-04	191	113	5	9214655dca96d766737c9f30b624d7fe7050342e
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN GJD2 MADD PER3 PRKCA	1.27e-04	191	113	5	a251b134f67a0a1ef3a42f50042f128a17f20b22
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)-D122\|Adult / Lineage, Cell type, age group and donor	DOCK8 BACH1 SIGLEC1 SIPA1L2 SOAT1	1.33e-04	193	113	5	cc1b6d3bf56e4a88f6fe23dd036a83cf5538c958
ToppCell	droplet-Fat-Scat-18m-Mesenchymal-Cd34+\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPZ STEAP3 LOXL3 DCLK1 ADGRD1	1.33e-04	193	113	5	316ebdf15f75d88c348f909b643fcd315364ca84
ToppCell	droplet-Fat-Scat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPZ STEAP3 LOXL3 DCLK1 ADGRD1	1.33e-04	193	113	5	1afdd3f7d703f4204a2cbfe40e135ac7b09213f7
ToppCell	droplet-Fat-Scat-18m-Mesenchymal\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPZ STEAP3 LOXL3 DCLK1 ADGRD1	1.33e-04	193	113	5	8dc6db335678f3a5cfd36026ad811fed8d9cb4bc
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RELN TSHZ2 CHI3L1 TMEM130 ERP27	1.36e-04	194	113	5	43eb677a76634bb9a48a40e0d607c4936ae64bcc
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	KNTC1 DYNC2I2 CDC45 CCNE2 CCDC15	1.40e-04	195	113	5	cec7df321f372d05c94f97d6bb18891a5cc3dec3
ToppCell	Monocytes-M2-like_CD16+_macrophages\|World / Immune cells in Kidney/Urine in Lupus Nephritis	ADORA3 PER3 P2RY6 LOXL3 SIGLEC1	1.40e-04	195	113	5	10fa47bdcf6c9784ea930b75a5861e139421feed
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN FRYL MADD NISCH PRKCA	1.40e-04	195	113	5	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)\|Adult / Lineage, Cell type, age group and donor	DOCK8 BACH1 SIGLEC1 SIPA1L2 SOAT1	1.40e-04	195	113	5	55e25f702af19146a161861cfd15f40bbda1dc35
ToppCell	COVID-19_Severe-Classical_Monocyte-cMono_4\|COVID-19_Severe / Disease condition and Cell class	BACH1 IFNGR2 XAF1 SIGLEC1 PLK3	1.40e-04	195	113	5	787ea9f38ad8e2a836222ca97f4d927f7e79517d
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GJD2 MADD TH PRKCA PLK3	1.40e-04	195	113	5	58b769da05a8f6b05aeb08d4f8b112941087ad00
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RELN TSHZ2 TMEM130 ERP27 SIPA1L2	1.43e-04	196	113	5	34e79918a448f6c19b87e1b1ce13c012b24be1f8
ToppCell	COVID-19_Mild-Classical_Monocyte-cMono_4\|COVID-19_Mild / Disease condition and Cell class	BACH1 TGFB1 IFNGR2 XAF1 SIGLEC1	1.43e-04	196	113	5	3729d1444c65cad640377894decc64129bc3fd5b
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RELN TSHZ2 TMEM130 ERP27 SIPA1L2	1.43e-04	196	113	5	8f82e01ca50aa4cd6149547505b4474a02fad618
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage_proliferating_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	DYNC2I2 TUBG1 CDC45 CCDC15 SLC47A1	1.43e-04	196	113	5	34bd155e6d848eb53d613997c0e244535de30ba3
ToppCell	PBMC-Control-cDC_3\|Control / Compartment, Disease Groups and Clusters	CYLD DOCK8 PEX11B GIPR LY75	1.43e-04	196	113	5	09d197b321ff9f13c0672ea059c850845b0dbbd5
ToppCell	medial-Hematologic-Myeloid_Dendritic_Type_1\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GALR1 TNFSF4 VAC14 P2RY6 LY75	1.46e-04	197	113	5	5bd2f32137fd849931e52093d630d2e7e27daf4f
ToppCell	medial-Hematologic-Myeloid_Dendritic_Type_1-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GALR1 TNFSF4 VAC14 P2RY6 LY75	1.46e-04	197	113	5	d9baa0be469fd8737a74b5078d30ce7d66759160
ToppCell	medial-2-Hematologic-Myeloid_Dendritic_Type_1\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GALR1 TNFSF4 VAC14 P2RY6 LY75	1.46e-04	197	113	5	3c1147857de6a7ab6b0cf77f5a6364d4c8669693
ToppCell	(2)_Fibroblasts-(22)_Fibro-3\|(2)_Fibroblasts / Cell class and subclass of bone marrow stroma cells in homeostatis	RELN TSHZ2 CHI3L1 LHX2 CRISPLD1	1.46e-04	197	113	5	d9021bab82403e566ec10f78acb227c0f80b88fe
ToppCell	CD8+_Memory_T_cell-CV-3\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	TNFSF4 TGFB1 GIPR PLK3 ARAP1	1.46e-04	197	113	5	9fe3d53346a95c1bbb0fc6a2f2e974889873424b
ToppCell	CV-Moderate-3\|CV / Virus stimulation, Condition and Cluster	TNFSF4 TGFB1 GIPR PLK3 ARAP1	1.46e-04	197	113	5	7031286e300eaccf73b927939f8de3a9d2d5fc74
ToppCell	severe-T/NK_proliferative\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	KNTC1 DYNC2I2 TUBG1 CDC45 CCNE2	1.57e-04	200	113	5	9d6e7e2d6cfa8c96bbb5c187815df96ecaa5475c
ToppCell	Transverse-(2)_B_cell-(24)_B_cell_cycling\|Transverse / shred on region, Cell_type, and subtype	KNTC1 DYNC2I2 ZNF862 CDC45 CCDC15	1.57e-04	200	113	5	e3f9736227151f23f0e331eec0a7a15ce464b517
ToppCell	Transverse-B_cell-B_cell_cycling\|Transverse / Region, Cell class and subclass	KNTC1 DYNC2I2 ZNF862 CDC45 CCDC15	1.57e-04	200	113	5	0e270f8019d9f22068ca426d661937262a5cd331
ToppCell	mild-immature_Neutrophil\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	KNTC1 NR2C2 RANGAP1 VSTM1	1.71e-04	109	113	4	2f03d6ee8b13424cc6a5bc60ac3461b44dff9d79
Disease	dyslexia (implicated_via_orthology)	DCLK2 DCLK1	1.30e-05	2	107	2	DOID:4428 (implicated_via_orthology)
Disease	3-methylxanthine measurement	NR2C2 LHX2	1.29e-04	5	107	2	EFO_0021175
Disease	Thymoma	CYLD BAP1	1.29e-04	5	107	2	C0040100
Disease	Thymic Carcinoma	CYLD BAP1	2.70e-04	7	107	2	C0205969
Disease	multiple myeloma (is_marker_for)	CHI3L1 TGFB1 NOX1	3.03e-04	36	107	3	DOID:9538 (is_marker_for)
Disease	type 1 diabetes mellitus (implicated_via_orthology)	DOCK8 TNFSF4 IFNGR2	3.85e-04	39	107	3	DOID:9744 (implicated_via_orthology)
Disease	serum gamma-glutamyl transferase measurement	BACH1 DHDDS SEMA4G TGFB1 SLCO1B7 EVA1C PKD1 PKHD1 SIGLEC1 LRBA SIPA1L2	4.92e-04	914	107	11	EFO_0004532
Disease	Asthma, Occupational	TGFB1 PRKCA	5.75e-04	10	107	2	C0264423
Disease	Paraganglioma	TMEM127 BAP1	9.90e-04	13	107	2	C0030421
Disease	hypertension (implicated_via_orthology)	RAG1 TGFB1 NISCH PRKCA	1.23e-03	128	107	4	DOID:10763 (implicated_via_orthology)
Disease	Alzheimer disease, polygenic risk score	FRAS1 DHDDS GIPR VAC14 PKHD1 LRBA LY75 GABBR1	1.35e-03	586	107	8	EFO_0030082, MONDO_0004975
Disease	Urticaria	SELE TGFB1	1.51e-03	16	107	2	C0042109
Disease	autosomal recessive polycystic kidney disease (implicated_via_orthology)	PKD1 PKHD1	1.51e-03	16	107	2	DOID:0110861 (implicated_via_orthology)
Disease	Pheochromocytoma, Extra-Adrenal	TMEM127 TH	1.51e-03	16	107	2	C1257877
Disease	Pheochromocytoma	TMEM127 TH	2.14e-03	19	107	2	C0031511
Disease	type 1 diabetes mellitus (is_marker_for)	SELE CHI3L1 TGFB1	2.31e-03	72	107	3	DOID:9744 (is_marker_for)
Disease	dilated cardiomyopathy	PKD1 PRKCA	2.37e-03	20	107	2	EFO_0000407
Disease	serum IgM measurement	TNFSF4 SIGLEC1	2.87e-03	22	107	2	EFO_0004993
Disease	Hereditary Paraganglioma-Pheochromocytoma Syndrome	TMEM127 BAP1	3.14e-03	23	107	2	C1708353
Disease	traumatic brain injury (biomarker_via_orthology)	TGFB1 NOX1	3.41e-03	24	107	2	DOID:0081292 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
RIFSFINDSIVYLHC	UMODL1	1201	Q5DID0
FRDQLASIFLACTSH	DDX52	331	Q9Y2R4
VLAACSSYFHSRIVG	BACH1	51	O14867
LCFITYSVHQSAKQR	GJD2	91	Q9UKL4
EYHRNVTFLSCQFVS	ADORA3	156	P0DMS8
YSVCRCTHLTNFAIL	ADGRD1	536	Q6QNK2
LRNTSLESYLCSFVH	FAM106A	21	Q4KMX7
CLLASFVTYIVHQSA	ADGRA1	31	Q86SQ6
FQYRILTAAALCHFT	CCNE2	291	O96020
RRTHNYDEFICTFIS	BAP1	666	Q92560
HCTRNYIHINLFTSF	GIPR	166	P48546
YQRLSETCTFAKLTH	ANO9	246	A1A5B4
AHSCRLLNQTDTVYT	ATP10B	926	O94823
LDFRLHFSCSSYLIT	AP3D1	1036	O14617
LAIRVNTFLSCSQYH	RAG1	471	P15918
ESCSFARHSLLQTLY	RANGAP1	571	P46060
LNVHYICESASRLLF	NR2C2	381	P49116
ASYAVILCHVRRAAS	OR4N4C	216	A0A096LPK9
RSQLFCLATYAGLHV	NOX5	236	Q96PH1
IIAHLFNFDCYSRSR	NOX1	116	Q9Y5S8
ILTFRLSYCHSNIVN	OR8U8	161	P0C7N1
TEAHLSLCSLEFYRA	LOXL3	251	P58215
FLLSESIYRHQHVCS	FRAS1	3361	Q86XX4
VLCLFSYVAAVHSSE	MADD	1621	Q8WXG6
REETLASSVAYCFTH	NLRC3	441	Q7RTR2
ALATCFTVASLSYHR	GPR162	101	Q16538
FNSICNHRYFATTSI	GNAT1	246	P11488
AVVCLSFNIYNSHVR	GABBR1	606	Q9UBS5
TTLAHACANVRALTY	KCNH5	621	Q8NCM2
SAHCSFYRTRTLQTL	DCLK1	36	O15075
SAHCSFYRTRTLQAL	DCLK2	51	Q8N568
YSVSCSPFHRNLFLS	DYNC2I2	396	Q96EX3
LDRFLCTHIIYSFAN	CHI3L1	46	P36222
TLDALNYALRCVHSV	PER3	76	P56645
GSINSCAHTVYAFRI	OR2L5	151	Q8NG80
RAISFAGCTAQHFLY	OR2T7	81	P0C7T2
ASYAVILCHVRRAAS	OR4N4	216	Q8N0Y3
VISYRSCITQLFFLH	OR4N5	91	Q8IXE1
EVALQTALSCSSRHY	FRYL	1811	O94915
VVCRYLHDSFSDTTF	FRYL	2166	O94915
CTRNAIHANLFASFV	GCGR	171	P47871
VHSQCFVITSDNRYI	LRBA	2596	P50851
AVLYCASNHSFLATI	LY75	836	O60449
ASAYCQQRYTHLVAI	SELE	36	P16581
LTFAHRTRALQCLFY	KNTC1	1881	P50748
ARDLVYHLNCFTCTT	LHX2	131	P50458
NIFCSYIFTHARTKT	GBP6	266	Q6ZN66
THSCLRSVLEQIAAY	TUBGCP5	306	Q96RT8
KNSSRSHCIFTIYLE	KIF9	211	Q9HAQ2
VSRFAQYCSLHVSAL	GPR83	146	Q9NYM4
ILTFRLSYCHSNIVN	OR8U9	161	P0C7N5
SQSRYSIAFPLLCTH	NCKAP1	561	Q9Y2A7
CSRYHLQRILVSDTF	RELN	2421	P78509
YQCFSILPQSSTHIR	MED14	901	O60244
RSYITDNCSLLSFHR	MYO15B	1431	Q96JP2
SFLFRITAHCLAYSN	GALR1	281	P47211
QCPRHSTISVQSAFY	EVA1C	76	P58658
LHDSLCNTSYTAARF	CDC45	286	O75419
THVEAVYSRRCVSFI	HEATR5B	346	Q9P2D3
LASCSQYFRSLFSSH	KLHL14	51	Q9P2G3
LQLRTCSDAAYNHTT	CPZ	46	Q66K79
TYLTHCFATLRALIA	DOCK8	1476	Q8NF50
DHFTLSIYNNVCRSL	DNAH3	3351	Q8TD57
LSCTFLLVLHASFSY	DCST1	381	Q5T197
RVYSDLSSICRAAVH	CRISPLD1	436	Q9H336
LLSFAHANCTLIISY	DPCD	156	Q9BVM2
SNIFRVGHLSNISCY	IFNGR2	221	P38484
LTHYNITGNTICLFR	ERP27	96	Q96DN0
SFQTLNHCRLSTLGY	KRTAP24-1	161	Q3LI83
LFAVLCIETSHYVAF	CYLD	861	Q9NQC7
NVCFAYTSRHEISNA	DHDDS	151	Q86SQ9
ITVSHLNRALYFACD	PEX11B	86	O96011
HGSILFLTCISFQRY	P2RY6	111	Q15077
LSSRVNRAHYFTSIC	PKD1	1361	P98161
CASHLTVVIIFYAAS	OR6A2	246	O95222
LFCLANSNYERTHSR	MT-ND4	326	P03905
ILTFRLSYCHSNIVN	OR8U1	161	Q8NH10
FQASTHYRRTICSKV	SFI1	706	A8K8P3
TTVSLCFLTQNYRHA	VAC14	631	Q08AM6
RTSICFQYEVSAVHN	MRPL39	271	Q9NYK5
SAVVHEYALAVCLSF	SOAT1	456	P35610
CYSSLFHLCFISIDR	TAAR6	116	Q96RI8
TQLHSCFQTVDRLYF	PRKCA	401	P17252
SVAAENSVICSFLHY	FGD1	816	P98174
HTSYLDQRVASFCTL	SIPA1L2	1601	Q9P2F8
TQNIAHSCTRYGLFV	PKHD1	2361	P08F94
CSATVHLLSQVLYFF	SLCO1B7	366	G3V0H7
VHLYCRLFQTAITRA	MRPS2	246	Q9Y399
IYAVSHLFEALACTS	SLC47A1	381	Q96FL8
RAYTRALHSFINSCD	CCDC15	911	Q0P6D6
AYSKRFISVACISHV	ARAP1	366	Q96P48
QSFTLAREACRSYSH	CHST6	156	Q9GZX3
SHDCKYLQSTISFRI	TOP3B	421	O95985
VARNRSACTYLASHL	PLK3	606	Q9H4B4
TYICLHFSALQVSHR	TNFSF4	41	P23510
FLQRLNSTHLYACGT	SEMA4G	121	Q9NTN9
VIFVAVFREHYSSLC	STEAP3	86	Q658P3
VFREHYSSLCSLSDQ	STEAP3	91	Q658P3
HTSISSLFERTCRQY	TUBG1	381	P23258
SLQDRSCLAVLTAHY	TBL3	181	Q12788
HVLRCFAAYGSAVLT	WDR97	261	A6NE52
HRRALDTNYCFSSTE	TGFB1	276	P01137
VSANFTLHEAYCLRF	XAF1	16	Q6GPH4
TCLTRDSYLTHCFLQ	NISCH	1256	Q9Y2I1
TEFALHLYQSVAACR	SERPINE3	31	A8MV23
LFERATFLVISHYQC	RRAGB	266	Q5VZM2
RFAAITLTQAGAYHC	SIGLEC1	946	Q9BZZ2
FLVATRAHAGAYSCQ	SIGLEC1	1311	Q9BZZ2
ALARIHDICYNSTTL	nan	361	Q6ZUG5
CASQFRTPSTYISHL	TSHZ2	931	Q9NRE2
LSVFIIYRCSQHSSS	VSTM1	151	Q6UX27
SSGRRFSHVYTCAQV	ZNF862	1091	O60290
YCFSIRAENIISKTH	TMEM130	311	Q8N3G9
SHLFACTRDSYEALV	RAPGEFL1	391	Q9UHV5
YAVSSRHNVICQLLS	POTEH	381	Q6S545
VLSSLVYFHCSALIC	ZP2	606	Q05996
STNLAIISFYVRHSC	ZFYVE26	2171	Q68DK2
LIDSLHSYCFSSRQN	THAP4	341	Q8WY91
TRRYAFAHILTVLQC	TMEM127	126	O75204
KAFSYCSSLTQHRRI	ZNF184	481	Q99676
ELVRNHAFSTRCYSF	VWA5B1	476	Q5TIE3
FRVFQCTQYIRHASS	TH	336	P07101