Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	regulation of proteasomal protein catabolic process	TMEM67 CSNK1D CSNK1E USP9X OSBPL7 TMF1 ZYG11B OPHN1	3.02e-06	213	86	8	GO:0061136
GeneOntologyBiologicalProcess	regulation of proteolysis involved in protein catabolic process	TMEM67 CSNK1D CSNK1E USP9X OSBPL7 TMF1 ZYG11B OPHN1	1.13e-05	255	86	8	GO:1903050
GeneOntologyBiologicalProcess	regulation of protein catabolic process	TMEM67 CSNK1D CSNK1E USP9X OSBPL7 TMF1 ZYG11B OPHN1 PCSK9	4.99e-05	407	86	9	GO:0042176
Domain	Clathrin_H-chain_propeller_rpt	CLTCL1 CLTC	2.14e-05	2	87	2	IPR022365
Domain	Clathrin-link	CLTCL1 CLTC	2.14e-05	2	87	2	PF09268
Domain	-	CLTCL1 CLTC	2.14e-05	2	87	2	2.130.10.110
Domain	Clathrin_H-chain_link/propller	CLTCL1 CLTC	2.14e-05	2	87	2	IPR016025
Domain	Clathrin_propel	CLTCL1 CLTC	2.14e-05	2	87	2	PF01394
Domain	Clathrin_heavy_chain	CLTCL1 CLTC	2.14e-05	2	87	2	IPR016341
Domain	Clathrin_H-chain_linker_core	CLTCL1 CLTC	2.14e-05	2	87	2	IPR015348
Domain	Clathrin_H-chain_propeller_N	CLTCL1 CLTC	2.14e-05	2	87	2	IPR001473
Domain	Clathrin_H-chain_linker	CLTCL1 CLTC	6.42e-05	3	87	2	IPR012331
Domain	CLH	CLTCL1 CLTC	6.42e-05	3	87	2	SM00299
Domain	FAM47	FAM47C FAM47B	1.28e-04	4	87	2	PF14642
Domain	FAM47	FAM47C FAM47B	1.28e-04	4	87	2	IPR032743
Domain	NUT	NUTM2B NUTM2A	2.13e-04	5	87	2	IPR024310
Domain	NUT_N	NUTM2B NUTM2A	2.13e-04	5	87	2	IPR024309
Domain	NUT	NUTM2B NUTM2A	2.13e-04	5	87	2	PF12881
Domain	CLIC	CLIC1 CLIC6	3.18e-04	6	87	2	IPR002946
Domain	Clathrin	CLTCL1 CLTC	4.44e-04	7	87	2	PF00637
Domain	Peptidase_M13	ECEL1 ECE2	4.44e-04	7	87	2	PF01431
Domain	Peptidase_M13_C	ECEL1 ECE2	4.44e-04	7	87	2	IPR018497
Domain	Peptidase_M13	ECEL1 ECE2	4.44e-04	7	87	2	IPR000718
Domain	Peptidase_M13_N	ECEL1 ECE2	4.44e-04	7	87	2	PF05649
Domain	Peptidase_M13_N	ECEL1 ECE2	4.44e-04	7	87	2	IPR008753
Domain	CHCR	CLTCL1 CLTC	4.44e-04	7	87	2	PS50236
Domain	GST_CTER	GSTM4 CLIC1 CLIC6	5.26e-04	34	87	3	PS50405
Domain	Clathrin_H-chain/VPS_repeat	CLTCL1 CLTC	5.90e-04	8	87	2	IPR000547
Domain	Glutathione-S-Trfase_C-like	GSTM4 CLIC1 CLIC6	7.90e-04	39	87	3	IPR010987
Domain	-	GSTM4 CLIC1 CLIC6	7.90e-04	39	87	3	1.20.1050.10
Domain	Integrin_alpha	ITGA8 ITGA5	1.15e-03	11	87	2	PF00357
Domain	Integrin_alpha_C_CS	ITGA8 ITGA5	2.47e-03	16	87	2	IPR018184
Domain	-	GSTM4 CLIC1 CLIC6 NXNL2	2.54e-03	122	87	4	3.40.30.10
Domain	Integrin_alpha-2	ITGA8 ITGA5	3.13e-03	18	87	2	IPR013649
Domain	Integrin_alpha2	ITGA8 ITGA5	3.13e-03	18	87	2	PF08441
Domain	Integrin_alpha	ITGA8 ITGA5	3.13e-03	18	87	2	IPR000413
Domain	INTEGRIN_ALPHA	ITGA8 ITGA5	3.13e-03	18	87	2	PS00242
Domain	Thioredoxin-like_fold	GSTM4 CLIC1 CLIC6 NXNL2	3.37e-03	132	87	4	IPR012336
Domain	Int_alpha_beta-p	ITGA8 ITGA5	3.48e-03	19	87	2	IPR013519
Domain	Int_alpha	ITGA8 ITGA5	3.48e-03	19	87	2	SM00191
Domain	FG_GAP	ITGA8 ITGA5	4.66e-03	22	87	2	PS51470
Domain	FG-GAP	ITGA8 ITGA5	5.54e-03	24	87	2	PF01839
Domain	FG-GAP	ITGA8 ITGA5	5.54e-03	24	87	2	IPR013517
Domain	Integrin_dom	ITGA8 ITGA5	6.00e-03	25	87	2	IPR032695
Domain	Glutathione_S-Trfase_N	GSTM4 CLIC1	6.98e-03	27	87	2	IPR004045
Pubmed	Characterization of a second human clathrin heavy chain polypeptide gene (CLH-22) from chromosome 22q11.	CLTCL1 CLTC	6.48e-06	2	89	2	8733129
Pubmed	Casein kinase I delta/epsilon phosphorylates topoisomerase IIalpha at serine-1106 and modulates DNA cleavage activity.	CSNK1D CSNK1E	6.48e-06	2	89	2	19043076
Pubmed	CK1δ and CK1ε are components of human 40S subunit precursors required for cytoplasmic 40S maturation.	CSNK1D CSNK1E	6.48e-06	2	89	2	24424021
Pubmed	CHC22 and CHC17 clathrins have distinct biochemical properties and display differential regulation and function.	CLTCL1 CLTC	6.48e-06	2	89	2	29097553
Pubmed	Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle.	CSNK1D CSNK1E	6.48e-06	2	89	2	9632646
Pubmed	The clathrin heavy chain isoform CHC22 functions in a novel endosomal sorting step.	CLTCL1 CLTC	6.48e-06	2	89	2	20065094
Pubmed	Effects of altered expression and activity levels of CK1δ and ɛ on tumor growth and survival of colorectal cancer patients.	CSNK1D CSNK1E	6.48e-06	2	89	2	25404202
Pubmed	An evaluation of polymorphisms in casein kinase 1 delta and epsilon genes in major psychiatric disorders.	CSNK1D CSNK1E	6.48e-06	2	89	2	22981886
Pubmed	CIS associates with the interleukin-2 receptor beta chain and inhibits interleukin-2-dependent signaling.	CISH IL2RB	6.48e-06	2	89	2	10514520
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	TMEM67 PTPRF CLIC1 ENPP1 FSTL4 TMTC2 ECEL1 H6PD ITGA5 CEMIP2 DMXL1 PCSK9 SLC4A2	1.15e-05	1201	89	13	35696571
Pubmed	Targeting of the circadian clock via CK1δ/ε to improve glucose homeostasis in obesity.	CSNK1D CSNK1E	1.94e-05	3	89	2	27439882
Pubmed	Functional equivalence of the clathrin heavy chains CHC17 and CHC22 in endocytosis and mitosis.	CLTCL1 CLTC	1.94e-05	3	89	2	19509056
Pubmed	The clinicopathologic features of YWHAE-FAM22 endometrial stromal sarcomas: a histologically high-grade and clinically aggressive tumor.	NUTM2B NUTM2A	1.94e-05	3	89	2	22456610
Pubmed	CKIepsilon/delta-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock.	CSNK1D CSNK1E	1.94e-05	3	89	2	19805222
Pubmed	Centrosomal anchoring of the protein kinase CK1delta mediated by attachment to the large, coiled-coil scaffolding protein CG-NAP/AKAP450.	CSNK1D CSNK1E	1.94e-05	3	89	2	12270714
Pubmed	Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG.	CLTCL1 CLTC	1.94e-05	3	89	2	22891263
Pubmed	Casein kinase 1 proteomics reveal prohibitin 2 function in molecular clock.	CSNK1D CSNK1E	1.94e-05	3	89	2	22384121
Pubmed	The Daple-CK1ε complex regulates Dvl2 phosphorylation and canonical Wnt signaling.	CCDC88C CSNK1E	1.94e-05	3	89	2	32888647
Pubmed	Gene expression levels of Casein kinase 1 (CK1) isoforms are correlated to adiponectin levels in adipose tissue of morbid obese patients and site-specific phosphorylation mediated by CK1 influences multimerization of adiponectin.	CSNK1D CSNK1E	1.94e-05	3	89	2	25724478
Pubmed	A comparative study of structural and conformational properties of casein kinase-1 isoforms: insights from molecular dynamics and principal component analysis.	CSNK1D CSNK1E	1.94e-05	3	89	2	25665722
Pubmed	CRISPR-mediated gene targeting of CK1δ/ε leads to enhanced understanding of their role in endocytosis via phosphoregulation of GAPVD1.	CSNK1D CSNK1E	1.94e-05	3	89	2	32321936
Pubmed	Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regeneration.	CLTCL1 CLTC	1.94e-05	3	89	2	15133132
Pubmed	Casein kinase 1-epsilon or 1-delta required for Wnt-mediated intestinal stem cell maintenance.	CSNK1D CSNK1E	1.94e-05	3	89	2	28963394
Pubmed	Human Rad17 C-terminal tail is phosphorylated by concerted action of CK1δ/ε and CK2 to promote interaction with the 9-1-1 complex.	CSNK1D CSNK1E	1.94e-05	3	89	2	31353086
Pubmed	Sequence analysis of the cDNA for the human casein kinase I delta (CSNK1D) gene and its chromosomal localization.	CSNK1D CSNK1E	1.94e-05	3	89	2	8786104
Pubmed	The clinical phenotype of YWHAE-NUTM2B/E positive pediatric clear cell sarcoma of the kidney.	NUTM2E NUTM2B	1.94e-05	3	89	2	26542179
Pubmed	CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch.	CSNK1D CSNK1E	3.87e-05	4	89	2	29784789
Pubmed	Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in the pathogenesis of familial Parkinson's disease caused by CHCHD2.	CSNK1D CSNK1E	3.87e-05	4	89	2	37578019
Pubmed	Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth.	CSNK1D CSNK1E	3.87e-05	4	89	2	21422228
Pubmed	The DNA-binding activity of mouse DNA methyltransferase 1 is regulated by phosphorylation with casein kinase 1delta/epsilon.	CSNK1D CSNK1E	3.87e-05	4	89	2	20192920
Pubmed	Therapeutic Targeting of Casein Kinase 1δ/ε in an Alzheimer's Disease Mouse Model.	CSNK1D CSNK1E	3.87e-05	4	89	2	31334659
Pubmed	One of two chondrocyte-expressed isoforms of cartilage intermediate-layer protein functions as an insulin-like growth factor 1 antagonist.	CILP2 ENPP1	3.87e-05	4	89	2	12746903
Pubmed	p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs.	CSNK1D CSNK1E	3.87e-05	4	89	2	9349507
Pubmed	Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family.	CSNK1D CSNK1E	3.87e-05	4	89	2	7797465
Pubmed	Casein kinase 1 delta (CK1delta) regulates period length of the mouse suprachiasmatic circadian clock in vitro.	CSNK1D CSNK1E	3.87e-05	4	89	2	20421981
Pubmed	Involvement of casein kinase Iepsilon in cytokine-induced granulocytic differentiation.	CSNK1D CSNK1E	3.87e-05	4	89	2	15070676
Pubmed	HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2.	CLTCL1 CLTC	3.87e-05	4	89	2	11517213
Pubmed	Phosphorylation of human enhancer filamentation 1 (HEF1) stimulates interaction with Polo-like kinase 1 leading to HEF1 localization to focal adhesions.	CSNK1D CSNK1E	6.44e-05	5	89	2	29191835
Pubmed	Control of intracellular dynamics of mammalian period proteins by casein kinase I epsilon (CKIepsilon) and CKIdelta in cultured cells.	CSNK1D CSNK1E	6.44e-05	5	89	2	11865049
Pubmed	Casein kinase 1 delta regulates the pace of the mammalian circadian clock.	CSNK1D CSNK1E	6.44e-05	5	89	2	19414593
Pubmed	Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon.	CSNK1D CSNK1E	6.44e-05	5	89	2	10848614
Pubmed	Desynchrony between brain and peripheral clocks caused by CK1δ/ε disruption in GABA neurons does not lead to adverse metabolic outcomes.	CSNK1D CSNK1E	6.44e-05	5	89	2	29463694
Pubmed	Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic.	CLTCL1 CLTC	6.44e-05	5	89	2	10436022
Pubmed	Wnt-3a utilizes a novel low dose and rapid pathway that does not require casein kinase 1-mediated phosphorylation of Dvl to activate beta-catenin.	CSNK1D CSNK1E	6.44e-05	5	89	2	17027228
Pubmed	The CK1δ/ε-AES axis regulates tumorigenesis and metastasis in colorectal cancer.	CSNK1D CSNK1E	6.44e-05	5	89	2	33754069
Pubmed	Essential roles of CKIdelta and CKIepsilon in the mammalian circadian clock.	CSNK1D CSNK1E	6.44e-05	5	89	2	19948962
Pubmed	mRNA levels of enzymes and receptors implicated in arachidonic acid metabolism in gliomas.	PTGER2 ALOX15	9.65e-05	6	89	2	20382140
Pubmed	Association of genetic variation in genes implicated in the beta-catenin destruction complex with risk of breast cancer.	CSNK1D CSNK1E	9.65e-05	6	89	2	18708403
Pubmed	A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP).	CSNK1D CSNK1E	9.65e-05	6	89	2	20048001
Pubmed	Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2.	CSNK1D CSNK1E	9.65e-05	6	89	2	17962809
Pubmed	Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex.	CSNK1D CSNK1E	9.65e-05	6	89	2	11818547
Pubmed	Physiological role for casein kinase 1 in glutamatergic synaptic transmission.	CSNK1D CSNK1E	9.65e-05	6	89	2	16014721
Pubmed	Identification of a novel Wnt5a-CK1ɛ-Dvl2-Plk1-mediated primary cilia disassembly pathway.	CSNK1D CSNK1E	9.65e-05	6	89	2	22609948
Pubmed	High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase.	CSNK1D CSNK1E	9.65e-05	6	89	2	21179498
Pubmed	SPOP-mediated ubiquitination and degradation of PDK1 suppresses AKT kinase activity and oncogenic functions.	CSNK1D CSNK1E	1.35e-04	7	89	2	34353330
Pubmed	A role for the CHC22 clathrin heavy-chain isoform in human glucose metabolism.	CLTCL1 CLTC	1.35e-04	7	89	2	19478182
Pubmed	Modeling of a human circadian mutation yields insights into clock regulation by PER2.	CSNK1D CSNK1E	1.35e-04	7	89	2	17218255
Pubmed	Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway.	CSNK1D CSNK1E	1.35e-04	7	89	2	12000790
Pubmed	SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis.	CSNK1D CSNK1E	1.35e-04	7	89	2	30177679
Pubmed	Casein kinase 1 delta (CK1delta) interacts with the SNARE associated protein snapin.	CSNK1D CSNK1E	1.79e-04	8	89	2	17101137
Pubmed	The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1.	CSNK1D CSNK1E	1.79e-04	8	89	2	21930935
Pubmed	Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism.	CSNK1D CSNK1E	1.79e-04	8	89	2	17244647
Pubmed	Genetic variation in immune signaling genes differentially expressed in asthmatic lung tissues.	IL2RB ALOX15	1.79e-04	8	89	2	18774388
Pubmed	Dysbindin structural homologue CK1BP is an isoform-selective binding partner of human casein kinase-1.	CSNK1D CSNK1E	1.79e-04	8	89	2	16618118
Pubmed	Hepatitis C virus enters liver cells using the CD81 receptor complex proteins calpain-5 and CBLB.	ENPP1 ITGA5 CEMIP2	1.99e-04	44	89	3	30024968
Pubmed	SDCBP promotes pancreatic cancer progression by preventing YAP1 from β-TrCP-mediated proteasomal degradation.	CSNK1D CSNK1E	2.30e-04	9	89	2	36828627
Pubmed	Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase.	CSNK1D CSNK1E	2.30e-04	9	89	2	20708156
Pubmed	Synucleins are a novel class of substrates for G protein-coupled receptor kinases.	CSNK1D GRK6	2.88e-04	10	89	2	10852916
Pubmed	CALM regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature.	CLTCL1 CLTC	2.88e-04	10	89	2	25898166
Pubmed	Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7.	CSNK1D CSNK1E	2.88e-04	10	89	2	25500533
Pubmed	Concordance of two multiple analytical approaches demonstrate that interaction between BMI and ADIPOQ haplotypes is a determinant of LDL cholesterol in a general French population.	ENPP1 PCSK9	2.88e-04	10	89	2	20186155
Pubmed	STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction.	WNT6 SOX18	3.51e-04	11	89	2	27131881
Pubmed	The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms.	CSNK1E FAM83E	3.51e-04	11	89	2	29789297
Pubmed	Emx2 patterns the neocortex by regulating FGF positional signaling.	ETV5 CDH8	3.51e-04	11	89	2	12872126
Pubmed	Ubiquitin-specific protease 8 deubiquitinates Sec31A and decreases large COPII carriers and collagen IV secretion.	CLTCL1 CLTC	3.51e-04	11	89	2	29604273
Pubmed	A role of OCRL in clathrin-coated pit dynamics and uncoating revealed by studies of Lowe syndrome cells.	CLTC PHETA1	4.20e-04	12	89	2	25107275
Pubmed	Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm.	CSNK1D CSNK1E	4.96e-04	13	89	2	18228528
Pubmed	A molecular mechanism for circadian clock negative feedback.	CSNK1D CSNK1E	4.96e-04	13	89	2	21680841
Pubmed	L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.	GRK6 B3GNT3 IL2RB SLC4A2	5.10e-04	143	89	4	20424473
Pubmed	Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.	CLTCL1 GRK6 PCSK9	5.24e-04	61	89	3	22916037
Pubmed	Shifted Transversal Design smart-pooling for high coverage interactome mapping.	MRI1 GLUL PRC1	5.49e-04	62	89	3	19447967
Pubmed	USP9X Deubiquitylates DVL2 to Regulate WNT Pathway Specification.	CSNK1D CSNK1E USP9X	5.49e-04	62	89	3	31340145
Pubmed	The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer.	USP9X UBR4	5.78e-04	14	89	2	27626314
Pubmed	Charting the molecular network of the drug target Bcr-Abl.	CASS4 USP9X UBR4 CLTC GAB1	6.20e-04	266	89	5	19380743
Pubmed	Association of CPI-17 with protein kinase C and casein kinase I.	CSNK1D CSNK1E	6.65e-04	15	89	2	15003508
Pubmed	Protein phosphatase 1α interacting proteins in the human brain.	CSRNP1 FRMPD4 CLTC	6.89e-04	67	89	3	22321011
Pubmed	ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.	MRI1 CSNK1E GRK6 CLTC TMF1 STEAP3 ITGA5 CEMIP2 SLC4A2	7.47e-04	952	89	9	38569033
Pubmed	USP7 Is a Tumor-Specific WNT Activator for APC-Mutated Colorectal Cancer by Mediating β-Catenin Deubiquitination.	CSNK1D CSNK1E	7.59e-04	16	89	2	29045831
Pubmed	Integrin requirement for hippocampal synaptic plasticity and spatial memory.	ITGA8 ITGA5	7.59e-04	16	89	2	12904471
Pubmed	Identification of a novel cell-adhesive protein spatiotemporally expressed in the basement membrane of mouse developing hair follicle.	ITGA8 ITGA5	7.59e-04	16	89	2	15878328
Pubmed	Cadherin expression in the developing mouse olfactory system.	TNFRSF19 CDH8	7.59e-04	16	89	2	17278136
Pubmed	The versican-hyaluronan complex provides an essential extracellular matrix niche for Flk1+ hematoendothelial progenitors.	HAS1 CEMIP2	7.59e-04	16	89	2	33454424
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	PRUNE2 SETBP1 UBR4 CLTC CAMTA1 GAB1	8.45e-04	430	89	6	35044719
Pubmed	BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.	PRUNE2 STEAP3 FAM91A1 PHETA1 DMXL1	8.45e-04	285	89	5	34369648
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	ENPP1 B3GNT3 H6PD ITGA5	8.52e-04	164	89	4	32409323
Pubmed	Gata3 is required for early morphogenesis and Fgf10 expression during otic development.	WNT6 ETV5	9.65e-04	18	89	2	16806848
Pubmed	Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.	CSNK1D CSNK1E DMXL1	9.95e-04	76	89	3	27542412
Pubmed	Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.	GSTM4 CAMTA1 PCSK9	9.95e-04	76	89	3	19336475
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	CILP2 CLIC1 CLTC ECEL1 H6PD ITGA5 CEMIP2	1.01e-03	613	89	7	22268729
Pubmed	Isthmin-1 (Ism1) modulates renal branching morphogenesis and mesenchyme condensation during early kidney development.	ITGA8 ETV5	1.08e-03	19	89	2	37185772
Interaction	CLGN interactions	TMEM67 ENPP1 ITLN1 ECEL1 B3GNT3 CEMIP2 PCSK9 SLC4A2	7.36e-06	235	86	8	int:CLGN
Interaction	RHOU interactions	PTPRF USP9X WNT6 GRK6 CLTC STEAP3 ITGA5 NDUFA10 GAB1 CEMIP2 SLC4A2	1.08e-05	510	86	11	int:RHOU
Interaction	DEFB135 interactions	TMEM67 CLTCL1 ITGA8 CEMIP2	3.06e-05	42	86	4	int:DEFB135
Cytoband	Ensembl 112 genes in cytogenetic band chrXp21	MAGEB18 FAM47C FAM47B	5.99e-04	84	89	3	chrXp21
Cytoband	Xq22	NXF5 FRMPD3	8.37e-04	22	89	2	Xq22
Cytoband	Xp21.1	FAM47C FAM47B	2.00e-03	34	89	2	Xp21.1
GeneFamily	Chloride intracellular channels	CLIC1 CLIC6	1.16e-04	6	51	2	307
GeneFamily	CD molecules\|Integrin alpha subunits	ITGA8 ITGA5	1.16e-03	18	51	2	1160
Coexpression	SERVITJA_ISLET_HNF1A_TARGETS_DN	GLP1R GLUL UGT2B10 ETV5 CDH8 PCSK9	2.08e-06	110	89	6	M2396
Coexpression	SERVITJA_ISLET_HNF1A_TARGETS_DN	GLP1R GLUL UGT2B10 ETV5 CDH8 PCSK9	3.63e-06	121	89	6	MM935
ToppCell	Thalamus-Neuronal\|Thalamus / BrainAtlas - Mouse McCarroll V32	RNF14 FRMPD4 RHOV ZYG11B CAMTA1 CDH8	2.49e-06	193	89	6	712a4acd1167e43543950bc819ff11984e6f718d
ToppCell	facs-Brain_Myeloid-Hippocampus\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CASS4 CSNK1E ETV5 FAM91A1 HAS1 OPHN1	2.64e-06	195	89	6	a1478021a3ed0e779716393124ca2a7770c433b7
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Fibroblasts\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CLTCL1 PTPRF COL5A3 ECEL1 LCMT2	1.59e-05	157	89	5	f086753b51860e23f1275bd75e8802d2a7d7b70a
ToppCell	Club-club-12\|World / Class top	RHOV ITLN1 BTLA CLIC6 ALOX15	2.02e-05	165	89	5	9b7a31cbdcd2f96b8bd08a4cd4141b92bd5e9062
ToppCell	Adult-Mesenchymal-vascular_smooth_muscle_cell-D175\|Adult / Lineage, Cell type, age group and donor	PRUNE2 ENPP1 ITGA8 COL5A3 IL2RB	2.14e-05	167	89	5	c4e321bb87512ea839f324c92c0f1afea891483f
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RHOV NCBP2L CLIC6 B3GNT3 ALOX15	2.27e-05	169	89	5	40b557549fe08c5dc9dba359af35993d68d1640a
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-regulatory_T_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CCDC88C ECEL1 NXNL2 PTGER2 IL2RB	2.40e-05	171	89	5	4c36d0bf5fa3ddc2144f60769bb288ca4e4e20bc
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-regulatory_T_cell-regulatory_T_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CCDC88C ECEL1 NXNL2 PTGER2 IL2RB	2.40e-05	171	89	5	c5c1d23b4040a78991512bfcbe046c51f202d2cf
ToppCell	Club-club-3\|World / Class top	RHOV ITLN1 FAM83E CLIC6 ALOX15	2.47e-05	172	89	5	34fbb82a2ec77dd183cf26b38edeb7e936b707bc
ToppCell	facs-Liver-Non-hepatocytes-3m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CIITA GRK6 BTLA ECEL1 CDH8	2.61e-05	174	89	5	8bdf5a97faf1cf0426d1a8851f8a3e27578f7598
ToppCell	facs-Liver-Non-hepatocytes-3m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CIITA GRK6 BTLA ECEL1 CDH8	2.61e-05	174	89	5	fbf998dd33ac27dad7639ea85fca393ba2835307
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c02-NCAM1\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TMEM67 ENPP1 NCBP2L IL2RB GAB1	2.68e-05	175	89	5	0c6cf88818037bef67211c1a8fcb1e7d47711c1d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC88C FSTL4 TMTC2 CEMIP2 OPHN1	3.23e-05	182	89	5	f96095b81188b52db8fcfca4837129cfcd9bd7b7
ToppCell	facs-Liver-Hepatocytes-24m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRF ENPP1 STEAP3 H6PD PCSK9	3.32e-05	183	89	5	d0721c6aa426953a520d40e976b6e65aa7ca65e8
ToppCell	RA-17._Lymphocyte\|World / Chamber and Cluster_Paper	CASS4 CCDC88C BTLA PTGER2 CEMIP2	3.32e-05	183	89	5	6397f684a50346fc42cccb5afbe10350f4b2d9b0
ToppCell	Club\|World / Class top	RHOV ITLN1 FAM83E CLIC6 ALOX15	3.49e-05	185	89	5	c3caf789e622ed515d143dc594158d52fdcffaef
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Degenerative_Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RHOV FSTL4 TMTC2 TNFRSF19 CLIC6	3.59e-05	186	89	5	b3358e0fa6d845c81e94d56c8575f016621d28ff
ToppCell	lymphoid-NK_cell-TNFRSF18+IL7R+_NK_cell\|lymphoid / Lineage, cell class and subclass	CLIC1 FRMPD3 PTGER2 IL2RB OPHN1	3.68e-05	187	89	5	99dfa50f6325b0d66d23ee8dcaa6437e7161628a
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CIITA SETBP1 BTLA GAB1 CEMIP2	3.77e-05	188	89	5	d8decd9b5967873ca8320c2f9f07365f163c777f
ToppCell	wk_08-11-Epithelial-Proximal_epithelial-Proximal_secretory_2\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	RHOV ITLN1 FAM83E CLIC6 B3GNT3	3.77e-05	188	89	5	07705bed928683470a52c8ccfa40ffb9a0971318
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLTC GLUL TMF1 HAS1 OPHN1	4.27e-05	193	89	5	06b65110db974f4ef90d3511ff34428976a52c9c
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CASS4 SETBP1 ITGA8 TNFRSF19 GAB1	4.27e-05	193	89	5	9f69edc97b868d23998abc98928a2e89a885ef8a
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLTC GLUL TMF1 HAS1 OPHN1	4.27e-05	193	89	5	9c16032bc03df8760ae199e8f19fdafa4c3f1827
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CISH PTPRF USP9X UBR4 CLTC	4.27e-05	193	89	5	471e65f02937bc18d7c5facdacdf1df58cf0f839
ToppCell	facs-Brain_Myeloid-Hippocampus-3m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLTC GLUL TMF1 HAS1 OPHN1	4.27e-05	193	89	5	a4f91bca5eaa985982d33a528f7566ffde154d47
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CISH PTPRF USP9X UBR4 CLTC	4.27e-05	193	89	5	fe451b3295d77b2bd1ac25cf29310c85835a45fe
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLTC GLUL TMF1 HAS1 OPHN1	4.27e-05	193	89	5	b39d7feaac4ff8f7409cd3d15e8f3c6391367275
ToppCell	droplet-Mammary_Gland-nan-21m-Epithelial-luminal_progenitor_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRF RHOV CLIC6 GAB1 ALOX15	4.38e-05	194	89	5	0ef63abcfd057079a9a6f8b27404ff521d44845d
ToppCell	(5)_Fibroblasts-(5)_Fibroblast-J_(Lipofibroblast)\|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)	CSRNP1 ITLN1 WNT6 HAS1 ALOX15	4.38e-05	194	89	5	784b15119c91ace33d34bfb3d68c182566a3e9a8
ToppCell	droplet-Mammary_Gland-nan-18m-Epithelial-luminal_epithelial_cell_of_mammary_gland\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRF RHOV GLUL CLIC6 CEMIP2	4.49e-05	195	89	5	18220efbd2d6ce6aa7501744fe430b6b46f2fc30
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig-Z\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CISH CCDC88C GRK6 PTGER2 IL2RB	4.60e-05	196	89	5	578afe58962a24874b99b0407a647b12e972344b
ToppCell	10x5'-GI_large-bowel-Lymphocytic_T_CD8-Trm_gut_CD8\|GI_large-bowel / Manually curated celltypes from each tissue	CISH CSRNP1 CLIC1 PTGER2 IL2RB	4.83e-05	198	89	5	712f28a3cafcf209e51e9ebc2ce5013a4141bf6d
ToppCell	facs-Lung-18m\|Lung / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CSRNP1 GLP1R TMF1 SOX18 TMTC2	4.94e-05	199	89	5	c11e0044d3cc37f6bb26df033ad4448b419addfc
Disease	Endometrial Stromal Sarcoma	NUTM2B NUTM2A	8.74e-05	5	88	2	C0206630
Disease	Clear cell sarcoma of kidney	NUTM2E NUTM2B	1.31e-04	6	88	2	C0334488
Disease	syndromic X-linked intellectual disability Najm type (implicated_via_orthology)	CSNK1D CSNK1E	1.83e-04	7	88	2	DOID:0060807 (implicated_via_orthology)
Disease	Gastro-enteropancreatic neuroendocrine tumor	CIITA IL2RB	9.00e-04	15	88	2	C2930967
Disease	intellectual disability (implicated_via_orthology)	UBR4 ITGA8 ITGA5	1.48e-03	75	88	3	DOID:1059 (implicated_via_orthology)
Disease	alcohol use disorder (implicated_via_orthology)	CLIC1 GLP1R GRK6 CLIC6	2.80e-03	195	88	4	DOID:1574 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
YLSDFRDALDPQCLA	SLC4A2	696	P04920
HFCDSLLDYCDPDRT	AGBL3	561	Q8NEM8
DADCLPSAAQIRSAY	CAMTA1	1446	Q9Y6Y1
ARALYDNCPDCSDEL	CASS4	16	Q9NQ75
SETGIYDNDPDLCFR	BTLA	221	Q7Z6A9
ELLNSDADPLCLYHF	CIITA	36	P33076
IEYADSSFRLDSNCL	CISH	131	Q9NSE2
AYARDEFTNTCPADQ	CLIC6	676	Q96NY7
LPLYALLAADDDSCY	DMXL1	1406	Q9Y485
SEDPLERSFLYCNQA	RAI1	521	Q7Z5J4
LEFSDCYLDSPDFRE	OPHN1	6	O60890
LFDFTPECRATYQDQ	FAM47C	871	Q5HY64
DECPSAFDGLYFLRT	ITLN1	46	Q8WWA0
PSAFPSCYEEALRDE	MAGEB18	296	Q96M61
DPALELSCYRDHQFS	NCBP2L	11	A6PVI3
SCDSFELLQALPDYS	CSRNP1	501	Q96S65
PATDLFCNRTFDEYA	GLP1R	56	P43220
SSQDCYDIPRAFPSD	GAB1	401	Q13480
YVQAFFALRDNPDLC	NCR3LG1	366	Q68D85
SYDSLPNFTAADCLR	FAM91A1	111	Q658Y4
HDTPSCRDDLLSDYF	CCDC88C	1686	Q9P219
LDRGVSPCEDFYQFS	ECE2	156	P0DPD6
PLYRRSDANCSGEDA	MPPE1	251	Q53F39
GNFRDDACLYSPASA	PCSK9	316	Q8NBP7
SDQSAYVSAIRDCFP	NXF5	226	Q9H1B4
ALAPESRACTYFAFA	PTGER2	101	P43116
YLNFCRSLRFDDKPD	CSNK1D	251	P48730
DDFRYACQSPEDTLV	FAM47B	56	Q8NA70
LTYSSFCPPDDLADR	ALOX15	436	P16050
RFLDDFESCPALYQR	GGACT	76	Q9BVM4
EDFSNCLYQDFRIPL	ENPP1	706	P22413
FEDSPAYLLDMDRCS	ETV5	486	P41161
LDASIDPCQDFYSFA	ECEL1	116	O95672
YAEFSPCRNSNADPE	ITGA8	181	P53708
NCSLEKFYDDPRSND	NDUFA10	111	O95299
DPNIFAYACDFSPRA	METTL6	101	Q8TCB7
DNFTRILEYAPCRSD	ITGA5	181	P08648
EPCASRARSYTLDNS	FRMPD3	621	Q5JV73
APCEADYRSLAQRSL	FRMPD4	616	Q14CM0
CSPGDLLRFDDYNSD	FSTL4	216	Q6MZW2
DAYCTFPSRDDLLLF	IL2RB	416	P14784
SAADPREYLCLDNSA	CEMIP2	741	Q9UHN6
SQRLSSFDPCFYRDL	B3GNT3	326	Q9Y2A9
EDPAYLRQCLASARA	HAS1	106	Q92839
DNAPEFASEYEAFLC	CDH8	491	P55286
EEYSERFSPQARSLC	GRK6	406	P43250
PFAYEDIARNINSSC	H6PD	146	O95479
FDVACTRLYNQPTDA	SLC25A35	226	Q3KQZ1
QAAFQACERYLPDCD	COL5A3	211	P25940
DDSQRFLSDHPYLVC	CDC37L1	176	Q7L3B6
SPQYACDFNLFLEDS	ERCC6L	946	Q2NKX8
QYCRADEARPNTIDF	PTPRF	856	P10586
YSSLLDQASRIADPC	OSBPL7	516	Q9BZF2
LCPDTETRLNAAYSF	TMEM67	356	Q5HYA8
DDSCNPRSVYENFRL	NUTM2A	321	Q8IVF1
DDSCNPRSVYENFRL	NUTM2B	321	A6NNL0
DDSCNPRSVYENFRL	NUTM2E	321	B1AL46
YLQLCPSSDTREDLF	GARIN3	151	Q8TC56
YFEDRRPSANCDPFS	GLUL	336	P15104
VSNRFSEYLLECPSA	USP9X	2096	Q93008
RSLAFYATCDAPVDN	PHETA1	6	Q8N4B1
VFAACFLPDSSRADY	PRUNE2	2921	Q8WUY3
AFSLEFRTLYAASCP	FAM83E	276	Q2M2I3
DVSNQLARVCYSPDF	GSTM4	106	Q03013
QAFAPFCAEDYTESL	PRC1	316	O43663
FYVAAPSSSCDLRLE	MRI1	276	Q9BV20
SENERFNCYPDADLA	SI	936	P14410
FCDADRPDAYTALVT	CILP2	796	Q8IUL8
NLDRAYEFAERCNEP	CLTC	1091	Q00610
NLDRAYEFAERCNEP	CLTCL1	1091	P53675
SNAYAREEFASTCPD	CLIC1	211	O00299
SPCFNRLFYAVDVDD	RNF14	451	Q9UBS8
LSASACPEYNRLDDF	TMF1	296	P82094
EEASPYSLLDICLNF	ZYG11B	11	Q9C0D3
DFDRLRSLCYPDTDV	RHOV	91	Q96L33
LYFAAARCAPSRDFT	NXNL2	31	Q5VZ03
RESNAEYLASLFPTC	STEAP3	126	Q658P3
LNTLSADFCYDDSRA	TMTC2	16	Q8N394
RADLLYAADSPDFCA	WNT6	281	Q9Y6F9
PLFRDCAAYTISAAA	SLC24A5	171	Q71RS6
ISPSRDNHYEFSDCE	ZNF33A	266	Q06730
SELSCFDRPQLHEYA	TNFRSF19	216	Q9NS68
ESRFDIVFADAYLPC	UGT2B10	141	P36537
EFDQYLNCSRTRPDA	SOX18	326	P35713
SRYNNCSISEEDFPE	ZCWPW2	66	Q504Y3
RGEPASALCFESADY	LCMT2	141	O60294
RFYCVLSPEASEDDL	UBR4	931	Q5T4S7
RYSFDFCSLDNPEAI	SETBP1	891	Q9Y6X0
YLNFCRSLRFDDKPD	CSNK1E	251	P49674