Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionRNA polymerase I general transcription initiation factor activity

UBTFL6 UBTF UBTFL1 TAF1

1.93e-089724GO:0001181
GeneOntologyMolecularFunctioncore promoter sequence-specific DNA binding

UBTFL6 UBTF UBTFL1 TAF1 RFX7 KCNIP3

4.48e-0855726GO:0001046
GeneOntologyMolecularFunctionRNA polymerase I core promoter sequence-specific DNA binding

UBTFL6 UBTF UBTFL1

7.26e-0611723GO:0001164
GeneOntologyMolecularFunctionRNA polymerase I transcription regulatory region sequence-specific DNA binding

UBTFL6 UBTF UBTFL1

1.25e-0513723GO:0001163
GeneOntologyMolecularFunctiongeneral transcription initiation factor activity

UBTFL6 UBTF UBTFL1 TAF1

1.06e-0468724GO:0140223
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

JAK1 JAK2 NRBP2 PNCK DCLK2 PRKDC TAF1 PAPSS1 ALPK2 STK25

2.19e-047097210GO:0016773
GeneOntologyMolecularFunctionprotein kinase activity

JAK1 JAK2 NRBP2 PNCK DCLK2 PRKDC TAF1 ALPK2 STK25

2.96e-04600729GO:0004672
GeneOntologyMolecularFunctionkinase activity

JAK1 JAK2 NRBP2 PNCK DCLK2 PRKDC TAF1 PAPSS1 ALPK2 STK25

3.98e-047647210GO:0016301
GeneOntologyMolecularFunctiongrowth hormone receptor binding

JAK1 JAK2

5.66e-0410722GO:0005131
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

NRBP2 PNCK DCLK2 PRKDC TAF1 ALPK2 STK25

1.12e-03446727GO:0004674
GeneOntologyBiologicalProcesstranscription initiation at RNA polymerase I promoter

UBTFL6 UBTF UBTFL1 TAF1

3.59e-0718704GO:0006361
GeneOntologyBiologicalProcessRNA polymerase I preinitiation complex assembly

UBTFL6 UBTF UBTFL1

6.06e-0611703GO:0001188
DomainFERM_central

JAK1 JAK2 FRMD4A TLN2

3.57e-0549714IPR019748
DomainFERM_domain

JAK1 JAK2 FRMD4A TLN2

3.57e-0549714IPR000299
DomainFERM_1

JAK1 JAK2 FRMD4A TLN2

3.87e-0550714PS00660
DomainFERM_2

JAK1 JAK2 FRMD4A TLN2

3.87e-0550714PS00661
DomainFERM_3

JAK1 JAK2 FRMD4A TLN2

3.87e-0550714PS50057
DomainBand_41_domain

JAK1 JAK2 FRMD4A TLN2

3.87e-0550714IPR019749
DomainB41

JAK1 JAK2 FRMD4A TLN2

3.87e-0550714SM00295
DomainHMG_BOX_2

UBTFL6 UBTF UBTFL1 TAF1

5.25e-0554714PS50118
DomainUbiquitin-rel_dom

FRMD4A ARAP3 RASSF1 PPP1R13B TLN2 ASPSCR1

7.10e-05184716IPR029071
DomainTyr_kinase_non-rcpt_Jak/Tyk2

JAK1 JAK2

8.51e-054712IPR016251
DomainLaminin_aI

LAMA1 LAMA2

1.41e-045712IPR009254
DomainLaminin_I

LAMA1 LAMA2

1.41e-045712PF06008
DomainLaminin_II

LAMA1 LAMA2

1.41e-045712PF06009
DomainLaminin_domII

LAMA1 LAMA2

1.41e-045712IPR010307
DomainLAMININ_IVA

LAMA1 LAMA2

3.93e-048712PS51115
DomainLaminin_B

LAMA1 LAMA2

3.93e-048712PF00052
DomainLamB

LAMA1 LAMA2

3.93e-048712SM00281
DomainLaminin_IV

LAMA1 LAMA2

3.93e-048712IPR000034
DomainLaminin_G_1

LAMA1 LAMA2

7.66e-0411712PF00054
DomainKinase-like_dom

JAK1 JAK2 NRBP2 PNCK DCLK2 PRKDC ALPK2 STK25

1.02e-03542718IPR011009
DomainHMG_box

UBTFL6 UBTF UBTFL1

1.08e-0353713PF00505
DomainOTU

OTUD4 TNFAIP3

1.08e-0313712PF02338
DomainRecoverin

KCNIP3 KCNIP2

1.08e-0313712IPR028846
DomainHMG

UBTFL6 UBTF UBTFL1

1.14e-0354713SM00398
DomainOTU

OTUD4 TNFAIP3

1.45e-0315712PS50802
DomainOTU_dom

OTUD4 TNFAIP3

1.45e-0315712IPR003323
DomainLaminin_N

LAMA1 LAMA2

1.65e-0316712IPR008211
DomainLAMININ_NTER

LAMA1 LAMA2

1.65e-0316712PS51117
DomainLaminin_N

LAMA1 LAMA2

1.65e-0316712PF00055
DomainLamNT

LAMA1 LAMA2

1.65e-0316712SM00136
DomainHMG_box_dom

UBTFL6 UBTF UBTFL1

1.94e-0365713IPR009071
DomainIGc2

NRCAM PSG9 MYPN ROBO2 ALPK2

2.00e-03235715SM00408
DomainIg_sub2

NRCAM PSG9 MYPN ROBO2 ALPK2

2.00e-03235715IPR003598
DomainFERM_CS

FRMD4A TLN2

3.73e-0324712IPR019747
DomainIG

SEMA3D NRCAM PSG9 MYPN ROBO2 ALPK2

5.28e-03421716SM00409
DomainIg_sub

SEMA3D NRCAM PSG9 MYPN ROBO2 ALPK2

5.28e-03421716IPR003599
DomainPH_dom-like

JAK1 JAK2 MAPK8IP1 FRMD4A ARAP3 TLN2

5.59e-03426716IPR011993
DomainEGF_LAM_2

LAMA1 LAMA2

5.79e-0330712PS50027
DomainEGF_LAM_1

LAMA1 LAMA2

5.79e-0330712PS01248
DomainIg_I-set

NRCAM MYPN ROBO2 ALPK2

5.93e-03190714IPR013098
DomainI-set

NRCAM MYPN ROBO2 ALPK2

5.93e-03190714PF07679
DomainFERM_N

FRMD4A TLN2

6.97e-0333712PF09379
DomainFERM_N

FRMD4A TLN2

6.97e-0333712IPR018979
DomainEF-hand_8

KCNIP3 KCNIP2

7.39e-0334712PF13833
DomainZnf-RING_LisH

TRIM73 TRIM74

7.39e-0334712IPR027370
Domainzf-RING_UBOX

TRIM73 TRIM74

7.39e-0334712PF13445
PathwayKEGG_MEDICUS_REFERENCE_TYPE_II_INTERFERON_TO_JAK_STAT_SIGNALING_PATHWAY

JAK1 JAK2 IFNA7

9.23e-0521603M47909
PathwayBIOCARTA_IFNG_PATHWAY

JAK1 JAK2

2.64e-046602MM1590
PathwayBIOCARTA_IFNG_PATHWAY

JAK1 JAK2

2.64e-046602M22085
PathwayKEGG_MEDICUS_REFERENCE_IFN_RIPK1_3_SIGNALING_PATHWAY

JAK1 JAK2 IFNA7

3.03e-0431603M47964
PathwayREACTOME_NRCAM_INTERACTIONS

NRCAM DLG3

3.69e-047602M27378
PathwayREACTOME_PHASE_1_INACTIVATION_OF_FAST_NA_CHANNELS

KCNIP3 KCNIP2

3.69e-047602M27457
PathwayREACTOME_PHASE_1_INACTIVATION_OF_FAST_NA_CHANNELS

KCNIP3 KCNIP2

3.69e-047602MM15199
PathwayBIOCARTA_STAT3_PATHWAY

JAK1 JAK2

4.91e-048602MM1576
PathwayBIOCARTA_STAT3_PATHWAY

JAK1 JAK2

4.91e-048602M22063
PathwayREACTOME_IFNG_SIGNALING_ACTIVATES_MAPKS

JAK1 JAK2

4.91e-048602M48010
PathwayWP_INTERFERONMEDIATED_SIGNALING

JAK1 JAK2 IFNA7

5.14e-0437603M39785
PathwayREACTOME_MAPK1_ERK2_ACTIVATION

JAK1 JAK2

6.29e-049602M26918
PathwayBIOCARTA_IL22BP_PATHWAY

JAK1 JAK2

6.29e-049602MM1419
PathwayREACTOME_ROBO_RECEPTORS_BIND_AKAP5

PPP3CB ROBO2

6.29e-049602M27877
PathwayBIOCARTA_IL22BP_PATHWAY

JAK1 JAK2

6.29e-049602M8066
PathwayREACTOME_MAPK3_ERK1_ACTIVATION

JAK1 JAK2

7.84e-0410602M26896
PathwayREACTOME_INTERLEUKIN_6_SIGNALING

JAK1 JAK2

9.56e-0411602M1014
PathwayREACTOME_INTERLEUKIN_27_SIGNALING

JAK1 JAK2

9.56e-0411602M27897
PathwayPID_INTEGRIN4_PATHWAY

LAMA1 LAMA2

9.56e-0411602M158
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

DOCK4 NRCAM SYNE1 RAB3GAP2 DZIP3 OTUD4 DLG3 SPEN

2.27e-0640773812693553
Pubmed

Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

DOCK4 SYNE1 SUPT7L PPP1R13B TMEM63A

2.40e-061017359872452
Pubmed

Transgenic overexpression of laminin alpha1 chain in laminin alpha2 chain-deficient mice rescues the disease throughout the lifespan.

LAMA1 LAMA2

4.35e-06273220544910
Pubmed

Behavior of CD34+ cells isolated from patients with polycythemia vera in NOD/SCID mice.

JAK2 PRKDC

4.35e-06273217764815
Pubmed

Anti-myeloma effects of ruxolitinib combined with bortezomib and lenalidomide: A rationale for JAK/STAT pathway inhibition in myeloma patients.

JAK1 JAK2

4.35e-06273228645562
Pubmed

Ruxolitinib suppresses liver fibrosis progression and accelerates fibrosis reversal via selectively targeting Janus kinase 1/2.

JAK1 JAK2

4.35e-06273235382859
Pubmed

Conserved neuron promoting activity in Drosophila and vertebrate laminin alpha1.

LAMA1 LAMA2

4.35e-0627328663504
Pubmed

Laminin α1 reduces muscular dystrophy in dy2J mice.

LAMA1 LAMA2

4.35e-06273229544677
Pubmed

Disruption of de novo fatty acid synthesis via acetyl-CoA carboxylase 1 inhibition prevents acute graft-versus-host disease.

ACACA TACC1

4.35e-06273227338930
Pubmed

Laminin 2 attachment selects myofibroblasts from fetal mouse lung.

LAMA1 LAMA2

4.35e-0627329728058
Pubmed

Important scaffold function of the Janus kinase 2 uncovered by a novel mouse model harboring a Jak2 activation-loop mutation.

JAK1 JAK2

4.35e-06273224169825
Pubmed

Lack of association of TNFAIP3 and JAK1 with Behçet's disease in the European population.

JAK1 TNFAIP3

4.35e-06273226005883
Pubmed

Oncogenic JAK1 and JAK2-activating mutations resistant to ATP-competitive inhibitors.

JAK1 JAK2

4.35e-06273221393331
Pubmed

Structure of human upstream binding factor HMG box 5 and site for binding of the cell-cycle regulatory factor TAF1.

UBTF TAF1

4.35e-06273217505112
Pubmed

Pharmacologic Inhibition of JAK1/JAK2 Signaling Reduces Experimental Murine Acute GVHD While Preserving GVT Effects.

JAK1 JAK2

4.35e-06273225977345
Pubmed

The Janus kinases inhibitor AZD1480 attenuates growth of small cell lung cancers in vitro and in vivo.

JAK1 JAK2

4.35e-06273224158701
Pubmed

Tyrosine kinase pathways modulate tumor susceptibility to natural killer cells.

JAK1 JAK2

4.35e-06273222684105
Pubmed

SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation.

JAK1 JAK2

4.35e-06273233827897
Pubmed

Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase.

JAK1 JAK2

4.35e-0627321848670
Pubmed

Ruxolitinib + capecitabine in advanced/metastatic pancreatic cancer after disease progression/intolerance to first-line therapy: JANUS 1 and 2 randomized phase III studies.

JAK1 JAK2

4.35e-06273229508247
Pubmed

Distinct roles for laminin globular domains in laminin alpha1 chain mediated rescue of murine laminin alpha2 chain deficiency.

LAMA1 LAMA2

4.35e-06273220657839
Pubmed

Preclinical evaluation of JAK1/2 inhibition by ruxolitinib in a murine model of chronic graft-versus-host disease.

JAK1 JAK2

4.35e-06273233811972
Pubmed

Long-term efficacy and safety of momelotinib, a JAK1 and JAK2 inhibitor, for the treatment of myelofibrosis.

JAK1 JAK2

4.35e-06273229263442
Pubmed

Therapeutic effect of JAK1/2 blockade on the manifestations of hemophagocytic lymphohistiocytosis in mice.

JAK1 JAK2

4.35e-06273227222478
Pubmed

Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations.

JAK1 JAK2

4.35e-06273227903500
Pubmed

Two members of the JAK family of protein tyrosine kinases map to chromosomes 1p31.3 and 9p24.

JAK1 JAK2

4.35e-0627321581631
Pubmed

Combined inhibition of Janus kinase 1/2 for the treatment of JAK2V617F-driven neoplasms: selective effects on mutant cells and improvements in measures of disease severity.

JAK1 JAK2

4.35e-06273219887489
Pubmed

Transcriptional repressor DREAM regulates T-lymphocyte proliferation and cytokine gene expression.

KCNIP3 KCNIP2

4.35e-06273216177826
Pubmed

Mapping the mammalian ribosome quality control complex interactome using proximity labeling approaches.

JAK1 DOCK4 ACACA OTUD4 CP ASPSCR1

4.39e-0620273629540532
Pubmed

The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome.

TRIM73 SEC31B TRIM74

4.87e-061673322792322
Pubmed

TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B.

JAK1 JAK2 IFNA7

9.86e-062073311694501
Pubmed

CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms.

JAK1 JAK2

1.30e-05373226175413
Pubmed

Frequency and prognostic implications of JAK 1-3 aberrations in Down syndrome acute lymphoblastic and myeloid leukemia.

JAK1 JAK2

1.30e-05373221537335
Pubmed

Janus kinases 1 and 2 regulate chemokine-mediated integrin activation and naïve T-cell homing.

JAK1 JAK2

1.30e-05373223526587
Pubmed

Progesterone activates Janus Kinase 1/2 and activators of transcription 1 (JAK1-2/STAT1) pathway in human spermatozoa.

JAK1 JAK2

1.30e-05373222748021
Pubmed

Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways.

JAK1 JAK2

1.30e-05373217550976
Pubmed

Constitutive activation of the Janus kinase-STAT pathway in T lymphoma overexpressing the Lck protein tyrosine kinase.

JAK1 JAK2

1.30e-0537329548458
Pubmed

Multiple Kv channel-interacting proteins contain an N-terminal transmembrane domain that regulates Kv4 channel trafficking and gating.

KCNIP3 KCNIP2

1.30e-05373218957440
Pubmed

Jak3 maps to chromosome 8.

JAK1 JAK2

1.30e-0537328662243
Pubmed

Structural organization and chromosomal mapping of JAK3 locus.

JAK1 JAK2

1.30e-0537328934548
Pubmed

Foot-and-mouth disease virus structural protein VP3 degrades Janus kinase 1 to inhibit IFN-γ signal transduction pathways.

JAK1 JAK2

1.30e-05373226901336
Pubmed

Induction of Jak/STAT signaling by activation of the type 1 TNF receptor.

JAK1 JAK2

1.30e-0537329510175
Pubmed

Involvement of JAK1, JAK2, and JAK3 in Stimulation of Functional Activity of Mesenchymal Progenitor Cells by Fibroblast Growth Factor.

JAK1 JAK2

1.30e-05373227905037
Pubmed

Three lysine residues in the common β chain of the interleukin-5 receptor are required for Janus kinase (JAK)-dependent receptor ubiquitination, endocytosis, and signaling.

JAK1 JAK2

1.30e-05373221965659
Pubmed

Signal transduction by the atopy-associated human thymic stromal lymphopoietin (TSLP) receptor depends on Janus kinase function.

JAK1 JAK2

1.30e-05373220128689
Pubmed

A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels.

KCNIP3 KCNIP2

1.30e-05373212829703
Pubmed

Implication of JAK1, JAK2, and JAK3 in the Realization of Proliferation and Differentiation Potential of Mesenchymal Progenitor Cells In Vitro.

JAK1 JAK2

1.30e-05373227383175
Pubmed

Age-associated inflammation inhibits epidermal stem cell function.

JAK1 JAK2

1.30e-05373222972935
Pubmed

CHD1 acts via the Hmgpi pathway to regulate mouse early embryogenesis.

UBTFL6 UBTFL1

1.30e-05373226092847
Pubmed

Efficacy of the Janus kinase 1/2 inhibitor ruxolitinib in the treatment of vasculopathy associated with TMEM173-activating mutations in 3 children.

JAK1 JAK2

1.30e-05373227554814
Pubmed

JAK mutations in high-risk childhood acute lymphoblastic leukemia.

JAK1 JAK2

1.30e-05373219470474
Pubmed

Gene structure variation in segmental duplication block C of human chromosome 7q 11.23 during primate evolution.

TRIM73 TRIM74

1.30e-05373226196062
Pubmed

Differential expression of laminin isoforms and alpha 6-beta 4 integrin subunits in the developing human and mouse intestine.

LAMA1 LAMA2

1.30e-0537327803849
Pubmed

LIF-independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease.

JAK1 JAK2

1.30e-05373221151131
Pubmed

A preliminary study of new single polymorphisms in the T helper type 17 pathway for psoriasis in the Korean population.

JAK1 JAK2

1.30e-05373227774581
Pubmed

Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components.

JAK1 JAK2

1.30e-0537328272873
Pubmed

The JAK1/2 Inhibitor Ruxolitinib Reverses Interleukin-6-Mediated Suppression of Drug-Detoxifying Proteins in Cultured Human Hepatocytes.

JAK1 JAK2

1.30e-05373229162613
Pubmed

Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction.

JAK1 JAK2

1.30e-0537328378315
Pubmed

Expression of laminin chains during myogenic differentiation.

LAMA1 LAMA2

1.30e-0537327510707
Pubmed

Jak2-mediated phosphorylation of Atoh1 is critical for medulloblastoma growth.

JAK2 PRKDC

1.30e-05373229168692
Pubmed

Dystroglycan is a binding protein of laminin and merosin in peripheral nerve.

LAMA1 LAMA2

1.30e-0537327925941
Pubmed

Laminin alpha1 chain mediated reduction of laminin alpha2 chain deficient muscular dystrophy involves integrin alpha7beta1 and dystroglycan.

LAMA1 LAMA2

1.30e-05373216504180
Pubmed

INCB16562, a JAK1/2 selective inhibitor, is efficacious against multiple myeloma cells and reverses the protective effects of cytokine and stromal cell support.

JAK1 JAK2

1.30e-05373220072651
Pubmed

Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130.

JAK1 JAK2

1.30e-05373210586060
Pubmed

YXXL motifs in SH2-Bbeta are phosphorylated by JAK2, JAK1, and platelet-derived growth factor receptor and are required for membrane ruffling.

JAK1 JAK2

1.30e-05373212551917
Pubmed

The Janus kinase family of protein tyrosine kinases and their role in signaling.

JAK1 JAK2

1.30e-05373210526570
Pubmed

Genome-wide identification of mouse congenital heart disease loci.

MKS1 DNAH11

1.30e-05373220511334
Pubmed

Amorfrutin A inhibits TNF-α induced JAK/STAT signaling, cell survival and proliferation of human cancer cells.

JAK1 JAK2

1.30e-05373228879797
Pubmed

Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells.

JAK1 JAK2

1.30e-05373215923602
Pubmed

Protein tyrosine phosphorylation as a mechanism which regulates cytokine activation of early response genes.

JAK1 JAK2

1.30e-0537327539296
Pubmed

Piperlongumine inhibits gastric cancer cells via suppression of the JAK1,2/STAT3 signaling pathway.

JAK1 JAK2

1.30e-05373227053336
Pubmed

The transcription factor DREAM represses the deubiquitinase A20 and mediates inflammation.

TNFAIP3 KCNIP3

1.30e-05373224487321
Pubmed

Brain alpha-dystroglycan displays unique glycoepitopes and preferential binding to laminin-10/11.

LAMA1 LAMA2

1.30e-05373216709410
Pubmed

TRIM50 protein regulates vesicular trafficking for acid secretion in gastric parietal cells.

TRIM73 TRIM74

1.30e-05373222872646
Pubmed

Hi-JAK-ing the ubiquitin system: The design and physicochemical optimisation of JAK PROTACs.

JAK1 JAK2

1.30e-05373232001089
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

JAK1 MAPK8IP1 PPP3CB NRCAM SYNE1 TLN2 DCLK2 PRKDC TAF1 CBFB SEC31B SLX4

1.41e-051285731235914814
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

PPP3CB UBTF RASSF1 MYPN DZIP3 OTUD4 TNFAIP3 SLX4 SBNO2 CHST8 STK25

1.56e-051084731111544199
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

DOCK4 MAPK8IP1 FRMD4A ACACA NRCAM ACADL RAB3GAP2 DLG3 TLN2 TACC1 DCLK2

2.46e-051139731136417873
Pubmed

Differential distribution of KChIPs mRNAs in adult mouse brain.

KCNIP3 KCNIP2

2.60e-05473215363885
Pubmed

Dipyrithione inhibits IFN-gamma-induced JAK/STAT1 signaling pathway activation and IP-10/CXCL10 expression in RAW264.7 cells.

JAK1 JAK2

2.60e-05473220372968
Pubmed

Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia.

JAK1 JAK2

2.60e-05473220139093
Pubmed

Structure, alternative splicing, and expression of the human and mouse KCNIP gene family.

KCNIP3 KCNIP2

2.60e-05473216112838
Pubmed

Simultaneous activation of JAK1 and JAK2 confers IL-3 independent growth on Ba/F3 pro-B cells.

JAK1 JAK2

2.60e-05473215988755
Pubmed

CUZD1 is a critical mediator of the JAK/STAT5 signaling pathway that controls mammary gland development during pregnancy.

JAK1 JAK2

2.60e-05473228278176
Pubmed

Molecular characterization of specific interactions between SHP-2 phosphatase and JAK tyrosine kinases.

JAK1 JAK2

2.60e-0547328995399
Pubmed

Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models.

PRKDC ABCD1

2.60e-05473239321266
Pubmed

The cell cycle regulatory factor TAF1 stimulates ribosomal DNA transcription by binding to the activator UBF.

UBTF TAF1

2.60e-05473212498690
Pubmed

Loss of JAK1 Drives Innate Immune Deficiency.

JAK1 JAK2

2.60e-05473230671064
Pubmed

Midkine induces tumor cell proliferation and binds to a high affinity signaling receptor associated with JAK tyrosine kinases.

JAK1 JAK2

2.60e-0547329452495
Pubmed

Molecular pathways: Jak/STAT pathway: mutations, inhibitors, and resistance.

JAK1 JAK2

2.60e-05473223406773
Pubmed

Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins.

JAK1 JAK2

2.60e-0547328657151
Pubmed

Modulation of A-type potassium channels by a family of calcium sensors.

KCNIP3 KCNIP2

2.60e-05473210676964
Pubmed

Specific effects of KChIP3/calsenilin/DREAM, but not KChIPs 1, 2 and 4, on calcium signalling and regulated secretion in PC12 cells.

KCNIP3 KCNIP2

2.60e-05473218393943
Pubmed

Box 2 region of the oncostatin M receptor determines specificity for recruitment of Janus kinases and STAT5 activation.

JAK1 JAK2

2.60e-05473218430728
Pubmed

Laminin alpha 1, alpha 2, alpha 4 and beta 1 chain mRNA expression in mouse embryonic, neonatal, and adult hearts.

LAMA1 LAMA2

2.60e-0547329201115
Pubmed

Cytokine receptor-like factor 1 (CRLF1) protects against 6-hydroxydopamine toxicity independent of the gp130/JAK signaling pathway.

JAK1 JAK2

2.60e-05473223818941
Pubmed

JAK2 and JAK1 constitutively associate with an interleukin-5 (IL-5) receptor alpha and betac subunit, respectively, and are activated upon IL-5 stimulation.

JAK1 JAK2

2.60e-0547329516124
Pubmed

Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta.

JAK1 JAK2

2.60e-0547329553136
Pubmed

Involvement of Janus kinases in the insulin signaling pathway.

JAK1 JAK2

2.60e-0547328536716
Pubmed

IL-4 regulates chemokine CCL26 in keratinocytes through the Jak1, 2/Stat6 signal transduction pathway: Implication for atopic dermatitis.

JAK1 JAK2

2.60e-05473222226123
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

JAK1 JAK2 FRMD4A TLN2

1.00e-05504941293
GeneFamilyLaminin subunits

LAMA1 LAMA2

4.67e-0412492626
GeneFamilyPotassium voltage-gated channel regulatory subunits|DASH family

KCNIP3 KCNIP2

7.39e-0415492858
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

NRCAM MYPN ROBO2 ALPK2

9.40e-04161494593
GeneFamilyOTU domain containing

OTUD4 TNFAIP3

9.53e-0417492669
CoexpressionHALLMARK_COMPLEMENT

DOCK4 JAK2 CP TNFAIP3 KCNIP3 KCNIP2

1.74e-05200716M5921
CoexpressionBONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING

SERPINB7 MAPK8IP1 FRMD4A PPP3CB SYNE1 DLG3 ASPSCR1 CHST8

6.69e-05506718M253
CoexpressionLEE_AGING_NEOCORTEX_DN

CP PRKDC DBP IFNA7

6.69e-0580714MM646
CoexpressionGSE40274_CTRL_VS_FOXP3_AND_EOS_TRANSDUCED_ACTIVATED_CD4_TCELL_UP

FRMD4A SNX20 DCLK2 ABCD1 TMEM63A

9.70e-05169715M9102
CoexpressionLAKE_ADULT_KIDNEY_C26_MESANGIAL_CELLS

DOCK4 FRMD4A SYNE1 LAMA2 TACC1

1.20e-04177715M39245
CoexpressionYAGI_AML_WITH_INV_16_TRANSLOCATION

DOCK4 TLN2 TACC1 TAF1 CBFB SPEN STK25

1.24e-04411717M1047
CoexpressionPARENT_MTOR_SIGNALING_UP

JAK2 SYNE1 PAFAH2 LAMA2 CP DBP PAPSS1 MKS1

1.47e-04567718M16909
CoexpressionATF2_S_UP.V1_DN

SERPINB7 ACACA LAMA1 LAMA2 SBNO2

1.56e-04187715M2681
CoexpressionBUSSLINGER_GASTRIC_IMMUNE_CELLS

JAK1 PPP3CB UBTF SYNE1 RAB3GAP2 DZIP3 OTUD4 TACC1 TNFAIP3 RFX7 CBFB SPEN SBNO2

1.65e-0414927113M40023
CoexpressionPUJANA_BREAST_CANCER_LIT_INT_NETWORK

JAK1 JAK2 ACACA PRKDC

1.66e-04101714M15356
CoexpressionGSE3982_DC_VS_NEUTROPHIL_DN

JAK1 ARAP3 DLG3 TNFAIP3 SPEN

1.99e-04197715M5462
CoexpressionGSE29618_PRE_VS_DAY7_POST_LAIV_FLU_VACCINE_PDC_DN

JAK2 PPP3CB RAB3GAP2 PAFAH2 OTUD4

2.03e-04198715M5001
CoexpressionGSE29618_LAIV_VS_TIV_FLU_VACCINE_DAY7_PDC_UP

JAK2 ACACA RAB3GAP2 OTUD4 TLN2

2.03e-04198715M5018
CoexpressionGSE2585_CD80_HIGH_VS_LOW_AIRE_KO_MTEC_DN

SERPINB7 ARAP3 UBTFL1 AMDHD2 CP

2.08e-04199715M6275
CoexpressionGSE37301_LYMPHOID_PRIMED_MPP_VS_GRAN_MONO_PROGENITOR_DN

ARAP3 RASSF1 AMDHD2 ASPSCR1 TACC1

2.08e-04199715M8861
CoexpressionDOUGLAS_BMI1_TARGETS_DN

PAFAH2 AMDHD2 OTUD4 TACC1 TNFAIP3 TMEM63A

2.10e-04314716M14279
CoexpressionGSE11961_FOLLICULAR_BCELL_VS_MEMORY_BCELL_DAY7_UP

JAK2 FRMD4A ACADL DZIP3 PPP1R13B

2.13e-04200715M9338
CoexpressionGSE13306_TREG_VS_TCONV_LAMINA_PROPRIA_DN

SYNE1 PPP1R13B CP PAPSS1 ALPK2

2.13e-04200715M3222
CoexpressionGSE41176_UNSTIM_VS_ANTI_IGM_STIM_BCELL_6H_DN

TCHH ACADL DBP SLC30A9 ALPK2

2.13e-04200715M9923
CoexpressionGSE17721_0.5H_VS_8H_PAM3CSK4_BMDC_DN

JAK2 CP CBFB PAPSS1 TLR8

2.13e-04200715M4111
CoexpressionGSE6259_FLT3L_INDUCED_33D1_POS_DC_VS_BCELL_DN

JAK1 PRKDC ABCD1 TAF1 TMEM63A

2.13e-04200715M6745
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA3D NRCAM SYNE1 PNCK TACC1 DCLK2 DNAH11

3.66e-08198737c12e7511628db819a52959bb68580e27c00c2e41
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA3D NRCAM SYNE1 PNCK DCLK2 DNAH11

8.97e-0719873622e766df1276c5b14aa0d83f434f47140ebb98ea
ToppCellLA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

MYPN PPP1R13B ROBO2 TNNT1 ALPK2

1.44e-051887356d249fe92d51a19da19ec14bb2262d394255d577
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-alveolar_fibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DOCK4 NRCAM ROBO2 CP CHST8

1.56e-05191735beb5bb42bd53bce01339da9110d374901548793c
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DOCK4 NRCAM ROBO2 CP CHST8

1.56e-051917356609d85fd2577633dcc067507304a6f9e5865ca3
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 SEMA3D ARAP3 TACC1 DCLK2

1.63e-051937351f978e102a029a6beb10913052cd0a20c7253e8e
ToppCelldroplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SEMA3D NRCAM LAMA2 CP PKDREJ

1.68e-051947357826fe5eb254ac032de0d978f39585a40e0b3ee4
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TCHH NRCAM ROBO2 CP TACC1

1.76e-05196735617103f4a09e009fe96c28eb5e40505a4fd6dcf4
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TCHH NRCAM ROBO2 CP TACC1

1.76e-05196735db64ab27374f82553ee577aec056141170f3656f
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 SEMA3D ARAP3 TACC1 DCLK2

1.76e-05196735e224338490691d92c1f70b57112fabdcc92b06a9
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 SEMA3D ARAP3 TACC1 DCLK2

1.80e-05197735c10dd1aaec01fb662eac83dfde90e3e426665d65
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MAPK8IP1 SYNE1 SPATA18 DZIP3 DNAH11

1.80e-0519773591637bdeab85024b5a02d1066f76cb803a2d6420
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MAPK8IP1 SYNE1 SPATA18 DZIP3 DNAH11

1.80e-0519773522c87dd15dc57bd0aa98a204c9fc9b3b9b573b45
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MAPK8IP1 SYNE1 SPATA18 DZIP3 DNAH11

1.80e-051977353bbf068d2ad8196fbc85d3f311a7c54c9aece856
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MAPK8IP1 SYNE1 SPATA18 DZIP3 DNAH11

1.80e-0519773587db09f341e2b20eb6e1c3e917cb5c960387b3e9
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 SEMA3D ARAP3 TACC1 DCLK2

1.80e-051977352844dbcd0a673ed81c99920aa45858651a00736d
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NRCAM SYNE1 TACC1 DCLK2 DNAH11

1.80e-05197735ac4f53acb2f8a428b0f2fab3c30a34e095a1bed7
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

DOCK4 SEMA3D NRCAM SYNE1 LAMA1

1.94e-052007359b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCellPND07-Immune-Immune_Myeloid-DC-maDC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

JAK2 SNX20 DCLK2 ALPK2

1.39e-041607347db30647b596f0c419087e6fabb9b99dcd5bddd4
ToppCellPND07-Immune-Immune_Myeloid-DC-maDC-maDC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

JAK2 SNX20 DCLK2 ALPK2

1.39e-0416073401f22cdb2a2f73776b7f91746e95c1850df94235
ToppCellE16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-Mature_Fibroblast_1|E16.5-samps / Age Group, Lineage, Cell class and subclass

DOCK4 TCHH CP TACC1

1.49e-04163734f1ec2625b52664308968b01d8e0275e1e0751480
ToppCell356C-Fibroblasts-Fibroblast-D|356C / Donor, Lineage, Cell class and subclass (all cells)

LAMA1 LAMA2 DCLK2 KCNIP2

1.60e-041667347286a37b2827f3747469ffd0d76cbe81116db7ee
ToppCell356C-Fibroblasts-Fibroblast-D-|356C / Donor, Lineage, Cell class and subclass (all cells)

LAMA1 LAMA2 DCLK2 KCNIP2

1.60e-041667347c2eee0a4f45795a956acf936b85bdb35f1b1624
ToppCellChildren_(3_yrs)-Mesenchymal-myofibroblast_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

NRCAM LAMA2 ROBO2 TLN2

1.60e-0416673494636dbc039f794c735960c3425e00bdd5523602
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Stem_cells-neuroepithelial-like_cells|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

ACACA PAFAH2 MKS1 PGBD3

1.63e-04167734e488d9c7cf4355959e3833de3bd496c13fc11b1b
ToppCellControl-Myeloid-MoAM1,_IL1R2|Myeloid / Condition, Lineage and Cell class

DOCK4 ARAP3 SYNE1 LAMA2

1.63e-041677346e5140527437193f441ca96893b9a00d346614f3
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 ARAP3 SYNE1 TACC1

1.71e-04169734987ff79ad563825dd9877ea8ccb536758f8c6700
ToppCelldroplet-Spleen-nan-3m-Myeloid-granulocyte|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TCHH ARAP3 SYNE1 TNNT1

1.75e-04170734dbd6c9c7be824a1ff1b31af791064127cafbd194
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FRMD4A SYNE1 LAMA2 ROBO2

1.83e-0417273408a3fe536b1b064c5ee7779bc2b1115a5963a26b
ToppCellCOVID-19-kidney-PEC|kidney / Disease (COVID-19 only), tissue and cell type

FRMD4A SYNE1 ROBO2 ALPK2

1.83e-0417273436a96714a0eb6ac438648135336c9791881ddadb
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FRMD4A SYNE1 LAMA2 ROBO2

1.83e-04172734553701349444eb366df3c11f54bb093434f153c6
ToppCelldroplet-Lung-3m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l26|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

JAK2 PAFAH2 TNFAIP3 SEC31B

1.87e-04173734120dd20e8a71f9169a1596b6171df7aa0b96dd15
ToppCelldroplet-Lung-3m-Hematologic-myeloid-Basophil/Mast_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

JAK2 PAFAH2 TNFAIP3 SEC31B

1.87e-04173734b2c55084ef6dac0e329c2e65c24cfe0045859c30
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Mesenchymal-skeletal_muscle_satellite_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRBP2 MYPN TLN2 SBNO2

1.91e-04174734f230d23618a6487f2664efb2c677e0a4559e2bf4
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NRCAM LAMA2 ROBO2 TLN2

1.95e-041757341799a7be623dc3bf53ba580a7c47d2619969d708
ToppCelldroplet-Kidney-KIDNEY-30m-Mesenchymal-podocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SUPT7L CP PRKDC CHST8

1.95e-0417573431f0fb2e47e357dbf9c15436b7df85b3c370ded7
ToppCellCOVID-19-kidney-Epi_(Mes)|kidney / Disease (COVID-19 only), tissue and cell type

FRMD4A SYNE1 CP ALPK2

2.13e-04179734e7c9dc63f03d3f3746b51a7e3c8393089e2ceb7d
ToppCellChildren_(3_yrs)-Mesenchymal-myofibroblast_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

NRCAM LAMA2 ROBO2 TLN2

2.17e-0418073401f2e5d96016823482f89ba503d007d4bd88eeac
ToppCellE18.5-samps-Mesenchymal-Matrix_fibroblast|E18.5-samps / Age Group, Lineage, Cell class and subclass

DOCK4 ROBO2 CP TACC1

2.27e-04182734ceb37c214662a48efb56ab0d015977c6fab478b0
ToppCellfacs-Skin-Anagen-3m-Epithelial-Basal_IFE|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SERPINB7 SEMA3D TNFAIP3 SBNO2

2.27e-0418273422d6f4790950508e8aa27e02a8133af5f53f13c8
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRCAM LAMA1 TLN2 DNAH11

2.36e-041847342cbed6462fea2622871bb7e49b0df3d984239281
ToppCellP28-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

NRCAM ROBO2 CP TACC1

2.36e-04184734924400f47e6b2cdf7b0d538df75857935cf0209b
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRCAM LAMA1 TLN2 DNAH11

2.36e-04184734ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRCAM LAMA1 TLN2 DNAH11

2.36e-041847342b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellCOVID-19-Heart-CM_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

MYPN LAMA2 TNNT1 ALPK2

2.41e-04185734549eeb521c3985bff396ea0f202db21822efa51f
ToppCellmild_COVID-19_(asymptomatic)-gd_T|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

SYNE1 RASSF1 TNFAIP3 TRIM74

2.46e-041867345fa3ed834898aa06aae15a8ade7ab93a6e4744f8
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SYNE1 LAMA1 PPP1R13B DNAH11

2.46e-04186734f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DOCK4 FRMD4A TCHH TNFAIP3

2.51e-0418773498026c1aaf8de280470ad75536121357934fc78d
ToppCellfacs-Skin-Telogen-3m-Epithelial-basal_cell_of_epidermis|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SERPINB7 SEMA3D RASSF1 TNFAIP3

2.51e-041877349c1013720c248ef201d010806b6e7ad24205e8ee
ToppCellControl-Fibroblasts-Other_FB|Control / group, cell type (main and fine annotations)

NRCAM LAMA2 ROBO2 TLN2

2.51e-04187734bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCellwk_08-11-Mesenchymal-Mesothelial-Early_mesothelial|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SEMA3D SLC5A12 DBP TNNT1

2.57e-041887346151051c027c7ff7d5d4bf5f1e11d7fe58eb22ed
ToppCellControl-Fibroblasts-Adventitial_FB|Control / group, cell type (main and fine annotations)

SEMA3D LAMA2 ROBO2 TLN2

2.57e-04188734706a26c372add839d947749f0521a0e1f5c9b0ec
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA3D TCHH NRCAM KCNIP3

2.57e-04188734a244fcd092d5bd544e503366b1439b0fbc1ee00e
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA3D TCHH NRCAM KCNIP3

2.57e-04188734c8530c9ff98666c64a94683261af4288cb790a7e
ToppCellfacs-Skin-Telogen-3m-Epithelial-Basal_IFE|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SERPINB7 SEMA3D RASSF1 TNFAIP3

2.57e-041887348cc927b4c51d982fdafa04dc7393617ad9bb220e
ToppCellrenal_medulla_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

NRCAM SYNE1 LAMA1 TACC1

2.62e-04189734830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCellMesenchymal-pericyte_cell|World / Lineage, Cell type, age group and donor

NRCAM LAMA2 TACC1 DCLK2

2.62e-04189734d7ed96add29f219183c802895fbff519b627f635
ToppCelldroplet-Heart-nan-18m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAPK8IP1 NRBP2 NRCAM MKS1

2.62e-041897340493f7b79127c207fd7ade778ef4810500495d7e
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 SEMA3D ARAP3 TACC1

2.67e-04190734656483751e4bf137e4e4bfb2a03a478a8f7fcb63
ToppCellRV-15._Ventricular_Cardiomyocyte_III|RV / Chamber and Cluster_Paper

JAK2 MYPN LAMA2 ALPK2

2.67e-0419073493c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|kidney / Disease (COVID-19 only), tissue and cell type

DOCK4 ARAP3 CP TACC1

2.67e-041907341519f34d31fe0817184c5865a0bc9f0cb479b1a4
ToppCell356C-Epithelial_cells-Epithelial-F_(Ciliated)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SPATA18 DZIP3 CP DNAH11

2.72e-04191734dad675251e129254955eac179c84a641a4864586
ToppCellE16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal|E16.5-samps / Age Group, Lineage, Cell class and subclass

DOCK4 TCHH NRCAM CP

2.72e-041917343379d145d34f89150f7b06d1340022cfc6b4a6ce
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FRMD4A NRCAM ROBO2 SBNO2

2.72e-0419173408720998aa55131d7377c4c67c4c935865bd7d79
ToppCell356C-Epithelial_cells-Epithelial-F_(Ciliated)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SPATA18 DZIP3 CP DNAH11

2.72e-041917346d2cf41ee946137c039ddcc13593fc3f670afbba
ToppCellPND01-03-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A|PND01-03-samps / Age Group, Lineage, Cell class and subclass

DOCK4 ROBO2 CP TACC1

2.72e-04191734e7c605b56934d1383237c1f946dbccef25d91368
ToppCellRA-09._Endothelium_I|World / Chamber and Cluster_Paper

DOCK4 ARAP3 SYNE1 TACC1

2.72e-04191734c8a0c2af119bc34a8f694a7d30642f28002c84b9
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 SEMA3D ARAP3 TACC1

2.78e-041927341ee4783051ec94ea94600f040edcb385fc4289f1
ToppCellBronchial_Biopsy-Epithelial-Ciliated_1|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

SYNE1 SPATA18 DZIP3 DNAH11

2.78e-04192734be592e661367affced9ebe80849b466e6adb3a34
ToppCellRA-09._Endothelium_I|RA / Chamber and Cluster_Paper

DOCK4 ARAP3 SYNE1 TACC1

2.78e-041927348a1b1c3e83a68ad74f8f4eb00455c9e41aa57cfc
ToppCellASK452-Epithelial-Ciliated|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

SPATA18 DZIP3 CP DNAH11

2.83e-04193734c0d10075862ac878aa05fc49c8b73e470783bf16
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

DOCK4 SEMA3D LAMA2 ROBO2

2.83e-041937349f69edc97b868d23998abc98928a2e89a885ef8a
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NRCAM LAMA2 ROBO2 CP

2.83e-041937344c74a3f69b2cbdf139e7e66b44bd86869ac34dc0
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NRCAM LAMA2 ROBO2 CP

2.83e-04193734ff8ceeb3cfd1bef7239df490c19d181091750833
ToppCellIPF-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

SYNE1 SPATA18 DZIP3 DNAH11

2.83e-04193734ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARAP3 ROBO2 TLN2 TACC1

2.83e-041937342483bb7f398e4fa0ef09c8bd584ed25703853f03
ToppCellBronchial_Biopsy-Epithelial-Ciliated_1|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

SYNE1 SPATA18 DZIP3 DNAH11

2.83e-041937340b62a6ddd7c42efd9f39781971d1438501e1fa8d
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 SEMA3D ARAP3 TACC1

2.83e-04193734287e756d5fd3bd2931c168da24beaa0d02a350ae
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MAPK8IP1 SPATA18 DZIP3 DNAH11

2.89e-041947343cd90d01ed5a5ce65aad8284dab2537ec16e3d7c
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

DOCK4 LAMA2 ROBO2 TLN2

2.89e-04194734e93de9428c986b8943fc169258847c650cfab0e5
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DOCK4 FRMD4A LAMA2 ROBO2

2.89e-04194734011e14d9ed1393275f892060e7708ffadcd0767f
ToppCellPND01-03-samps-Mesenchymal|PND01-03-samps / Age Group, Lineage, Cell class and subclass

DOCK4 ROBO2 CP TACC1

2.89e-041947344f9bd0ded0dde1df885850714f29e73e992539a5
ToppCellBronchial_Brush-Epithelial-Ciliated_1|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

SYNE1 SPATA18 DZIP3 DNAH11

2.89e-04194734b4ce60c06568123008b1081d644733cb91c28f51
ToppCellBronchial_Brush-Epithelial-Ciliated_1|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

SYNE1 SPATA18 DZIP3 DNAH11

2.89e-041947347a7ddccfe72a4a0dc4d1a5c809988f0069f9f1a3
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ACACA ACADL SYNE1 PPP1R13B

2.89e-0419473497534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 SEMA3D ARAP3 SYNE1

2.89e-04194734ad6c04ad0621689e3bf4c94ccd6e60653bbd02c7
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-Pericytes-Immature_pericyte|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TLN2 TACC1 DCLK2 DNAH11

2.89e-041947343b9ada901dfe7a5cc4861a883d3268c53b11e5b6
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NRCAM ROBO2 CP TACC1

2.95e-041957341c1135be421af98cd0077bec1ff2c4158d42aa21
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MAPK8IP1 SPATA18 DZIP3 DNAH11

2.95e-0419573479dc031258579ea328181dda33710dd897f1064a
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MAPK8IP1 SPATA18 DZIP3 DNAH11

2.95e-04195734db4270c135c392ed443670981656e3cd5b95939d
ToppCellmoderate-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

SYNE1 SPATA18 DZIP3 DNAH11

2.95e-041957343486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MAPK8IP1 SPATA18 DZIP3 DNAH11

2.95e-041957346365e3893e38231090ec2dbef010dec71dea3d07
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NRCAM ROBO2 CP TACC1

2.95e-041957341f005ee1da66b539bd200aaa98f46edbbc7f12e4
ToppCellE17.5-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

TCHH NRCAM CP TACC1

2.95e-04195734b072fdc2131173f562e55dd78226eaf2c57d3690
ToppCellCOVID-19_Severe-Lymphoid_T/NK-gd_T|COVID-19_Severe / Disease group, lineage and cell class

SYNE1 RASSF1 PAFAH2 LAMA2

2.95e-041957349990440bda7fac5d00ef80444fab07459be625e1
ToppCellBronchial-NucSeq|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations

DOCK4 ACACA ZCCHC7 RFX7

3.01e-04196734ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCellCOVID-19-kidney-VWF+PLVAP+VCAM1+EC|kidney / Disease (COVID-19 only), tissue and cell type

DOCK4 SEMA3D ARAP3 TACC1

3.01e-04196734ac2c4a325efa8497a755cd31fb6a9d94d8e3bf42
ToppCellPND01-03-samps-Mesenchymal-Matrix_fibroblast|PND01-03-samps / Age Group, Lineage, Cell class and subclass

DOCK4 ROBO2 CP TACC1

3.01e-0419673454f4cf778f95a9ff662e5c7520916a25e605bf95
ToppCellE18.5-Mesenchymal-Mesenchymal_structural|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TCHH ROBO2 CP TACC1

3.01e-0419673497e26622d9582b092c18ff5b7e957818f99d9631
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

SYNE1 RASSF1 PAFAH2 LAMA2

3.01e-04196734418e8e0a51c5cb60e3b903e7d2d800dc8b9f3d5c
DrugFlufenamic acid [530-78-9]; Up 200; 14.2uM; PC3; HT_HG-U133A

JAK2 UBTF SYNE1 PAFAH2 TAF1 CHST8 TMEM63A

2.31e-061957072104_UP
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

FRMD4A UBTF RASSF1 DLG3 ASPSCR1 SBNO2

1.40e-051707065417_DN
DrugCyclobenzaprine hydrochloride [6202-23-9]; Up 200; 12.8uM; HL60; HT_HG-U133A

ARAP3 PAFAH2 ASPSCR1 ABCD1 TNFAIP3 TLR8

2.79e-051927061332_UP
DrugTiletamine hydrochloride; Down 200; 15.4uM; MCF7; HT_HG-U133A

UBTF RASSF1 SUPT7L LSS SBNO2 TMEM63A

2.79e-051927066013_DN
DrugCarcinine [56897-53-1]; Down 200; 22uM; PC3; HT_HG-U133A

PAFAH2 ASPSCR1 DBP SBNO2 TMEM63A STK25

2.87e-051937064225_DN
Drugcarbamazepine; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA

JAK2 RASSF1 SUPT7L SPEN SBNO2 STK25

2.87e-05193706835_DN
DrugTropicamide [1508-75-4]; Down 200; 14uM; MCF7; HT_HG-U133A

FRMD4A PAFAH2 LSS TNFAIP3 SBNO2 TMEM63A

2.95e-051947063619_DN
DrugMethacycline hydrochloride [3963-95-9]; Down 200; 8.4uM; HL60; HT_HG-U133A

SYNE1 RAB3GAP2 PAFAH2 LSS ABCD1 SEC31B

3.04e-051957062901_DN
DrugHarpagoside [19210-12-9]; Down 200; 8uM; HL60; HT_HG-U133A

ARAP3 NRCAM PAFAH2 TNNT1 SBNO2 TMEM63A

3.13e-051967062935_DN
DrugMidecamycin [35457-80-8]; Down 200; 5uM; MCF7; HT_HG-U133A

UBTF SUPT7L DZIP3 ASPSCR1 TNFAIP3 STK25

3.22e-051977061526_DN
Drugdexamethasone; Up 200; 1uM; MCF7; HG-U133A

TCHH RASSF1 RAB3GAP2 TLN2 DBP SBNO2

3.22e-05197706255_UP
DrugSpiramycin [8025-81-8]; Down 200; 4.8uM; HL60; HT_HG-U133A

RAB3GAP2 LSS TNNT1 SBNO2 CHST8 TMEM63A

3.22e-051977062558_DN
DrugEpitiostanol [2363-58-8]; Down 200; 13uM; MCF7; HT_HG-U133A

FRMD4A RAB3GAP2 TACC1 ABCD1 TNFAIP3 TMEM63A

3.22e-051977067342_DN
Drugsulfate

JAK2 MAPK8IP1 LAMA1 AMDHD2 LAMA2 ROBO2 CP DLG3 TAF1 TNFAIP3 PAPSS1 IFNA7 PGBD3 CHST8

3.25e-0512927014CID000001117
DrugFlucytosine [2022-85-7]; Up 200; 31uM; MCF7; HT_HG-U133A

SUPT7L PAFAH2 LSS TAF1 TNFAIP3 TMEM63A

3.31e-051987065289_UP
DrugLevopropoxyphene napsylate [5714-90-9]; Down 200; 7.4uM; PC3; HT_HG-U133A

UBTF PAFAH2 DZIP3 ASPSCR1 TNFAIP3 TMEM63A

3.31e-051987065083_DN
DrugFenofibrate [49562-28-9]; Down 200; 11uM; MCF7; HT_HG-U133A

RASSF1 PAFAH2 DZIP3 TNFAIP3 RFX7 TMEM63A

3.31e-051987067474_DN
DrugPrazosin hydrochloride [19237-84-4]; Up 200; 9.6uM; PC3; HT_HG-U133A

JAK2 FRMD4A TAF1 TNFAIP3 DBP SBNO2

3.31e-051987066315_UP
Drugclozapine; Down 200; 10uM; MCF7; HT_HG-U133A_EA

SUPT7L PAFAH2 TACC1 ABCD1 TMEM63A STK25

3.31e-051987061009_DN
DrugMethacycline hydrochloride [3963-95-9]; Down 200; 8.4uM; PC3; HT_HG-U133A

JAK2 PAFAH2 TLN2 TNFAIP3 SBNO2 TMEM63A

3.31e-051987064062_DN
Drug(+,-)-Octopamine hydrochloride [770-05-8]; Down 200; 21uM; MCF7; HT_HG-U133A

DOCK4 JAK2 DZIP3 ASPSCR1 SBNO2 TMEM63A

3.40e-051997066491_DN
DrugPizotifen malate [5189-11-7]; Down 200; 9.4uM; MCF7; HT_HG-U133A

DOCK4 JAK2 TCHH NRCAM UBTF DZIP3

3.40e-051997066513_DN
Drugmagnolol

JAK1 JAK2 SYNE1 TNFAIP3

3.51e-0560704CID000072300
Drug4-octyne

SYNE1 CP

5.57e-054702CID000016029
Drugquinazoline

JAK1 SYNE1 SUPT7L PRKDC

6.81e-0571704CID000009210
Drugdimethoxyphenol

SYNE1 CP

1.39e-046702CID000078828
Drug2,6-di-tert-butylpyridine

SYNE1 CP

1.39e-046702CID000068510
Drugsodium acetylacetonate

ACACA SYNE1 CP

1.42e-0433703CID000018630
Drugpropacetamol

ABCD1 DBP

1.94e-047702CID000068865
DrugAC1MNCFH

SYNE1 CP

1.94e-047702CID003301780
DrugCpCp

ACACA CP

1.94e-047702CID000193370
Drugbaricitinib

JAK1 JAK2

1.94e-047702ctd:C000596027
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

JAK2 NRCAM UBTF DLG3 SBNO2

2.05e-041757056891_DN
Drugferrocene

ACADL SYNE1 CP

2.17e-0438703CID000007611
DrugMefloquine hydrochloride [51773-92-3]; Up 200; 9.6uM; MCF7; HT_HG-U133A

DOCK4 LSS TNFAIP3 SBNO2 TMEM63A

2.46e-041827056205_UP
DrugPhLi

ACACA SYNE1

2.58e-048702CID000637932
DrugWithaferin A [5119-48-2]; Down 200; 1uM; MCF7; HT_HG-U133A

JAK2 DZIP3 TACC1 TNFAIP3 MKS1

2.71e-041867053902_DN
DrugCantharidin [56-25-7]; Down 200; 20.4uM; HL60; HT_HG-U133A

JAK2 UBTF RAB3GAP2 OTUD4 TMEM63A

2.78e-041877053075_DN
DrugICI182,780; Down 200; 1uM; MCF7; HT_HG-U133A

JAK2 SUPT7L TLN2 SBNO2 STK25

2.85e-041887057091_DN
DrugPhenoxybenzamine hydrochloride [63-92-3]; Down 200; 11.8uM; MCF7; HT_HG-U133A

DOCK4 JAK2 FRMD4A OTUD4 ABCD1

2.92e-041897055248_DN
DrugSecurinine [5610-40-2]; Down 200; 18.4uM; MCF7; HT_HG-U133A

FRMD4A PAFAH2 TLN2 TACC1 DBP

2.92e-041897056831_DN
DrugEburnamonine (-) [4880-88-0]; Down 200; 13.6uM; PC3; HT_HG-U133A

ARAP3 DZIP3 DLG3 TAF1 TMEM63A

2.99e-041907057154_DN
DrugAntimycin A [1397-94-0]; Down 200; 7.2uM; MCF7; HT_HG-U133A

DOCK4 TCHH UBTF ASPSCR1 SBNO2

3.07e-041917052261_DN
DrugDienestrol [84-17-3]; Up 200; 15uM; MCF7; HT_HG-U133A

TCHH RASSF1 TNFAIP3 SBNO2 TMEM63A

3.07e-041917053448_UP
DrugFamprofazone [22881-35-2]; Down 200; 10.6uM; PC3; HT_HG-U133A

JAK2 SYNE1 PAFAH2 CHST8 TMEM63A

3.14e-041927053753_DN
DrugPHA-00851261E [724719-49-7]; Down 200; 10uM; PC3; HT_HG-U133A

PAFAH2 DLG3 ASPSCR1 SBNO2 TMEM63A

3.14e-041927054330_DN
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; HL60; HT_HG-U133A

TCHH NRCAM AMDHD2 TNNT1 TMEM63A

3.14e-041927053114_UP
DrugTMEDA

ACACA SYNE1 TNNT1

3.14e-0443703CID000008037
DrugC768-0445; Down 200; 10uM; MCF7; HT_HG-U133A_EA

RASSF1 SUPT7L LSS CBFB TMEM63A

3.22e-04193705865_DN
DrugCeforanide [60925-61-3]; Down 200; 7.6uM; PC3; HT_HG-U133A

JAK2 UBTF DZIP3 LSS PRKDC

3.22e-041937056751_DN
Drugtrichostatin A; Down 200; 0.1uM; ssMCF7; HG-U133A

JAK2 ACACA UBTF ASPSCR1 SBNO2

3.22e-04193705413_DN
DrugTocainide hydrochloride; Up 200; 17.4uM; MCF7; HT_HG-U133A

UBTF PAFAH2 LSS ASPSCR1 PRKDC

3.30e-041947054838_UP
DrugNafronyl oxalate [3200-06-4]; Up 200; 8.4uM; HL60; HT_HG-U133A

OTUD4 LSS ASPSCR1 SBNO2 CHST8

3.30e-041947051267_UP
DrugPrimaquine diphosphate [63-45-6]; Down 200; 8.8uM; PC3; HT_HG-U133A

JAK2 RAB3GAP2 SUPT7L DLG3 ASPSCR1

3.30e-041947054263_DN
DrugMorantel tartrate [26155-31-7]; Down 200; 10.8uM; MCF7; HT_HG-U133A

RASSF1 SUPT7L TACC1 SPEN TMEM63A

3.30e-041947051676_DN
DrugLynestrenol [52-76-6]; Up 200; 14uM; MCF7; HT_HG-U133A

JAK2 OTUD4 TAF1 TNFAIP3 TMEM63A

3.30e-041947055355_UP
DrugTiletamine hydrochloride; Down 200; 15.4uM; MCF7; HT_HG-U133A

AMDHD2 DZIP3 OTUD4 CHST8 TMEM63A

3.30e-041947056516_DN
DrugU794

SYNE1 CP

3.31e-049702CID000017548
DrugSDMP

ACACA SYNE1

3.31e-049702CID000094924
Drugdodecanal

ABCD1 SPEN

3.31e-049702CID000008194
Drugpyranone

SYNE1 ASPSCR1

3.31e-049702CID000119838
Drugthietane

SYNE1 CP

3.31e-049702CID000009251
DrugMedrysone [2668-66-8]; Down 200; 11.6uM; PC3; HT_HG-U133A

JAK2 SUPT7L PAFAH2 TLN2 SBNO2

3.37e-041957053705_DN
DrugAndrosterone [53-41-8]; Down 200; 13.8uM; HL60; HT_HG-U133A

JAK2 UBTF RASSF1 ABCD1 SPEN

3.37e-041957051296_DN
DrugPF-00875133-00 [351322-64-0]; Down 200; 10uM; MCF7; HT_HG-U133A

FRMD4A TCHH ASPSCR1 TACC1 CHST8

3.37e-041957055967_DN
DrugMetolazone [17560-51-9]; Down 200; 11uM; MCF7; HT_HG-U133A

PAFAH2 TLN2 LSS MKS1 SBNO2

3.37e-041957051514_DN
DrugRapamycin; Down 200; 0.1uM; HL60; HT_HG-U133A

UBTF RAB3GAP2 SUPT7L LSS TACC1

3.37e-041957051162_DN
DrugOzagrel hydrochloride [78712-43-3]; Up 200; 15.2uM; HL60; HT_HG-U133A

JAK2 LSS SBNO2 TMEM63A STK25

3.37e-041957052942_UP
DrugMycophenolic acid [24280-93-1]; Down 200; 12.4uM; PC3; HT_HG-U133A

RASSF1 OTUD4 TLN2 TAF1 TMEM63A

3.37e-041957054019_DN
DrugGemfibrozil [25812-30-0]; Up 200; 16uM; PC3; HT_HG-U133A

UBTF SYNE1 PAFAH2 DLG3 TMEM63A

3.37e-041957052113_UP
DrugBeta-sistosterol [83-46-5]; Down 200; 9.6uM; PC3; HT_HG-U133A

SYNE1 RAB3GAP2 PAFAH2 SBNO2 TMEM63A

3.37e-041957054073_DN
DrugCyclopenthiazide [742-20-1]; Down 200; 10.6uM; PC3; HT_HG-U133A

JAK2 SUPT7L PAFAH2 TAF1 TMEM63A

3.37e-041957054229_DN
DrugRanitidine hydrochloride [66357-59-3]; Down 200; 11.4uM; MCF7; HT_HG-U133A

JAK2 TLN2 LSS TNFAIP3 SBNO2

3.45e-041967055425_DN
DrugDebrisoquin sulfate [581-88-4]; Up 200; 9uM; MCF7; HT_HG-U133A

FRMD4A LSS TAF1 SPEN STK25

3.45e-041967055288_UP
DrugDiprophylline [479-18-5]; Down 200; 15.8uM; PC3; HT_HG-U133A

SYNE1 TLN2 ASPSCR1 SBNO2 TMEM63A

3.45e-041967055063_DN
DrugEstrone [53-16-7]; Up 200; 14.8uM; PC3; HT_HG-U133A

NRCAM RAB3GAP2 LSS TNFAIP3 TMEM63A

3.45e-041967056647_UP
DrugSpiramycin [8025-81-8]; Down 200; 4.8uM; PC3; HT_HG-U133A

FRMD4A SUPT7L ASPSCR1 DBP TMEM63A

3.45e-041967053762_DN
DrugEpivincamine [6835-99-0]; Down 200; 11.2uM; PC3; HT_HG-U133A

SYNE1 PAFAH2 LSS ASPSCR1 TMEM63A

3.45e-041967054500_DN
DrugFlupentixol dihydrochloride cis-(Z) [2413-38-9]; Up 200; 7.8uM; MCF7; HT_HG-U133A

RASSF1 SUPT7L TLN2 LSS STK25

3.45e-041967055307_UP
DrugDelcorine; Down 200; 8.4uM; MCF7; HT_HG-U133A

JAK2 PAFAH2 OTUD4 TLN2 TMEM63A

3.45e-041967053613_DN
Drugfluphenazine dihydrochloride; Down 200; 10uM; MCF7; HG-U133A

ACACA AMDHD2 TLN2 SBNO2 TMEM63A

3.54e-04197705490_DN
DrugCarbimazole [22232-54-8]; Up 200; 21.4uM; MCF7; HT_HG-U133A

DOCK4 SYNE1 DZIP3 TNFAIP3 CHST8

3.54e-041977053299_UP
DrugTrolox [53188-07-1]; Up 200; 16uM; PC3; HT_HG-U133A

RASSF1 PAFAH2 TLN2 TNFAIP3 TMEM63A

3.54e-041977057304_UP
DrugNitrofural [59-87-0]; Up 200; 20.2uM; MCF7; HT_HG-U133A

PAFAH2 DLG3 TLN2 ABCD1 STK25

3.54e-041977055321_UP
DrugPiperine [94-62-2]; Up 200; 14uM; HL60; HT_HG-U133A

DOCK4 PAFAH2 ASPSCR1 TLR8 TMEM63A

3.54e-041977051327_UP
DrugFuraltadone hydrochloride [3759-92-0]; Down 200; 11uM; HL60; HT_HG-U133A

LSS TNNT1 SEC31B SBNO2 CHST8

3.54e-041977052554_DN
DrugBenoxinate hydrochloride [5987-82-6]; Down 200; 11.6uM; PC3; HT_HG-U133A

JAK2 DZIP3 OTUD4 TAF1 DBP

3.54e-041977053996_DN
DrugHyoscyamine (L) [101-31-5]; Down 200; 13.8uM; PC3; HT_HG-U133A

PAFAH2 LSS TNFAIP3 TMEM63A STK25

3.62e-041987055099_DN
Drug0198306-0000 [212631-61-3]; Up 200; 10uM; MCF7; HT_HG-U133A

TLN2 TNFAIP3 SBNO2 CHST8 TMEM63A

3.62e-041987057064_UP
DrugCarbinoxamine maleate salt [3505-38-2]; Down 200; 9.8uM; MCF7; HT_HG-U133A

DLG3 TACC1 ABCD1 MKS1 STK25

3.62e-041987053466_DN
DrugClofazimine [2030-63-9]; Up 200; 8.4uM; MCF7; HT_HG-U133A

FRMD4A ABCD1 TAF1 TLR8 TMEM63A

3.70e-041997053239_UP
DrugGly-His-Lys acetate salt; Down 200; 1uM; PC3; HT_HG-U133A

SUPT7L PAFAH2 DZIP3 OTUD4 TMEM63A

3.70e-041997056560_DN
DrugTetrahydrozoline hydrochloride [522-48-5]; Down 200; 16.8uM; MCF7; HT_HG-U133A

FRMD4A DZIP3 TLN2 TACC1 TMEM63A

3.70e-041997056069_DN
DrugAmoxicillin [26787-78-0]; Up 200; 11uM; PC3; HT_HG-U133A

PAFAH2 AMDHD2 DZIP3 TNFAIP3 TMEM63A

3.70e-041997056285_UP
Drugcarmustine; Down 200; 100uM; MCF7; HT_HG-U133A

SUPT7L DZIP3 ABCD1 TMEM63A STK25

3.70e-041997056888_DN
Drugestradiol, USP; Up 200; 0.01uM; ssMCF7; HG-U133A

JAK2 TCHH RASSF1 ASPSCR1 TNFAIP3

3.70e-04199705373_UP
Drugprochlorperazine dimaleate salt; Down 200; 10uM; MCF7; HT_HG-U133A

TCHH UBTF TACC1 TAF1 SBNO2

3.70e-041997055575_DN
DrugMethylatropine nitrate [52-88-0]; Down 200; 11uM; MCF7; HT_HG-U133A

TCHH DZIP3 ASPSCR1 SBNO2 CHST8

3.70e-041997056495_DN
DrugDNA-PK Inhibitor III; Up 200; 1uM; PC3; HT_HG-U133A

JAK2 DZIP3 TLN2 CBFB CHST8

3.79e-042007057518_UP
DrugEtanidazole [22668-01-5]; Down 200; 18.6uM; HL60; HT_HG-U133A

JAK2 UBTF TAF1 SBNO2 STK25

3.79e-042007052510_DN
Diseasebeta-aminoisobutyric acid measurement

ARAP3 PAPSS1 CCDC26

2.61e-0524713EFO_0010464
Diseasedisease of cellular proliferation (implicated_via_orthology)

JAK1 JAK2

1.19e-047712DOID:14566 (implicated_via_orthology)
Diseaseatrioventricular septal defect (implicated_via_orthology)

MKS1 DNAH11

1.19e-047712DOID:0050651 (implicated_via_orthology)
Diseasenasopharynx carcinoma (is_marker_for)

JAK2 TNFAIP3 SPEN

1.54e-0443713DOID:9261 (is_marker_for)
DiseasePolycythemia Vera

JAK1 JAK2

1.58e-048712C0032463
DiseaseMalignant neoplasm of breast

ARAP3 NRCAM SYNE1 SPATA18 LAMA2 CBFB KCNIP3 SPEN PKDREJ PGBD3

2.41e-0410747110C0006142
DiseaseColorectal Carcinoma

ARAP3 ACACA NRCAM SYNE1 LAMA1 AMDHD2 DLG3 CHST8

2.80e-04702718C0009402
DiseaseMetastatic melanoma

PRKDC TAF1 ALPK2

3.03e-0454713C0278883
Diseaseglycerophosphorylcholine measurement

JAK1 DCLK2

3.10e-0411712EFO_0020018
Diseaseeosinophil percentage of leukocytes

JAK1 JAK2 PRKDC TNFAIP3 CCDC26 ALPK2 MKS1 SBNO2

4.20e-04746718EFO_0007991
Diseasehematologic cancer (implicated_via_orthology)

JAK1 JAK2

4.38e-0413712DOID:2531 (implicated_via_orthology)
Diseaseheart disease (biomarker_via_orthology)

JAK2 CP

7.58e-0417712DOID:114 (biomarker_via_orthology)
Diseasemuscular dystrophy (is_implicated_in)

SYNE1 LAMA2

7.58e-0417712DOID:9884 (is_implicated_in)
DiseaseLeukemia, Myelocytic, Acute

JAK1 JAK2 CBFB SLX4

8.17e-04173714C0023467
DiseaseHepatic Form of Wilson Disease

PPP3CB CP

1.52e-0324712C1527352
DiseaseHepatolenticular Degeneration

PPP3CB CP

1.52e-0324712C0019202
Diseaseneutrophil percentage of granulocytes

JAK1 JAK2 PRKDC CCDC26

2.25e-03228714EFO_0007994

Protein segments in the cluster

PeptideGeneStartEntry
REEPEHDFSKISIVR

TACC1

136

O75410
PDEFFELTVDDVRRR

ASPSCR1

341

Q9BZE9
KRFFRELDDPVTSAR

ARAP3

981

Q8WWN8
RIFSPEHDIFRKSVR

ACADL

51

P28330
FSRHLPKDARADFRE

ALPK2

756

Q86TB3
PRREHRREAAFTLED

DNAH11

851

Q96DT5
RDKFEEDRIYRHLEP

ACACA

1361

Q13085
PRREEVKFFLRHEDS

PPP1R13B

71

Q96KQ4
KPDRERVEDFDHTSR

OTUD4

421

Q01804
DDPRKFALFERAERH

RASSF1

241

Q9NS23
DPTHFEKRFLKRIRD

JAK1

866

P23458
FEDRDPTQFEERHLK

JAK2

836

O60674
FEDVQRCHFKRPREL

ABCD1

426

P33897
TFRVPVERKAEEEHL

CP

791

P00450
KDPEEARFFVRSIEH

RAB3GAP2

1026

Q9H2M9
IRAEREELRNLHFFP

NRBP2

211

Q9NSY0
RELPSDERFTVDKDH

NRCAM

586

Q92823
IFRFVPRHEDELELE

MAPK8IP1

496

Q9UQF2
FDRERHKDPSPRDRD

SPATA18

106

Q8TC71
SIELEHFEERDKRPR

DCLK2

6

Q8N568
EIKYTGFRDRPHEER

CBFB

26

Q13951
SCLKDRHEFRFPEEE

IFNA7

51

P01567
REEAPREHVESFFQK

KCNIP2

221

Q9NS61
KRFPEHRAAEIRETL

LSS

546

P48449
DDPRVHRTVTREDFL

LAMA2

1316

P24043
LVVDPETDEHFKRLR

SLC9A3R2

226

Q15599
PRDARKETVESHFRD

TMEM63A

236

O94886
DEFFVRHPAVEDQRK

DZIP3

6

Q86Y13
ESAKDFIRHLLERDP

PNCK

241

Q6P2M8
AILRNPEFFEHRKEE

PAPSS1

336

O43252
PEFFEHRKEERCARQ

PAPSS1

341

O43252
ERSSRDREEKEAPFF

CCDC26

21

Q8TAB7
REKKFSVEVHDPRRA

FRMD4A

266

Q9P2Q2
PVDKFRGAHIRFEFR

DOCK4

476

Q8N1I0
AEEDFTREPRKIILH

DLG3

376

Q92796
ETFDPRRHRFSEEEL

DBP

221

Q10586
EKDEFRHTETQRPFV

FAM172BP

26

A6NC97
LREDAPAEHVERFFE

KCNIP3

206

Q9Y2W7
HTLDDIRRLDRFKEP

PPP3CB

216

P16298
IPFRRVEEGEKEFHV

PAFAH2

166

Q99487
DEKPVDFLEFRRRVV

PGBD3

506

Q8N328
PEGERVDFDDIHRKR

TNNT1

56

P13805
RRLKHFIGQREEFET

SYNE1

8101

Q8NF91
KRLYPSREEFREHLE

TAF1

1436

P21675
THPDERLTRKDFFFI

PKDREJ

1346

Q9NTG1
KRGDETREEIRHFTF

PSG9

126

Q00887
VEKRGDREEAHVPFF

LAMA1

2531

P25391
RRKFHRVTAEEAKEP

SBNO2

1111

Q9Y2G9
FEVDFRDPSLDLKHR

SEC31B

46

Q9NQW1
SFDLLPREFRLVEVH

SUPT7L

21

O94864
HSRVDPEELFTKLDR

STK25

11

O00506
FKRADPERLRHASEE

SLX4

216

Q8IY92
RDFPDDVISFIKRHS

SEMA3D

411

O95025
FERLVSAFRDKFEHP

CHST8

261

Q9H2A9
FREEIEDVEFPRKHL

SNX20

131

Q7Z614
RREFQELRHPVDEEK

TRIM74

176

Q86UV6
IRKRRSTDFEFDPHS

TLR8

451

Q9NR97
EFEEKLARFREEHPD

UBTFL6

166

P0CB48
EEKLARFREEHPDLV

UBTFL1

161

P0CB47
HAQPEEEERERRVFK

MKS1

271

Q9NXB0
DERIDEFHPKATRTL

SPEN

426

Q96T58
VNRDRGRFEDLKVHF

TNFAIP3

276

P21580
FSEIFRKEHPERFIE

TKTL2

351

Q9H0I9
RADHPFLFVIRKDDI

SERPINB7

356

O75635
FFLRIVHGRRSKPDE

ROBO2

91

Q9HCK4
ELVEDRFRKPHAFAV

RFX7

991

Q2KHR2
FRRREQRDPTVHDDV

PRKDC

2066

P78527
RKADRHREVDEDFPR

ZCCHC7

461

Q8N3Z6
HPDVSDEVRTRALRF

TLN2

2226

Q9Y4G6
RREFQELRHPVDEEK

TRIM73

176

Q86UV7
RKIRRRSPHEDTESF

SLC30A9

151

Q6PML9
EFERNLARFREDHPD

UBTF

171

P17480
SRLHIFDFDVDPLRR

SLC5A12

221

Q1EHB4
LHRQERDRKFLEEEP

TCHH

1636

Q07283
PEKLFFEERRVADER

AMDHD2

41

Q9Y303
RDKEPLQERFFRPHF

MYPN

1061

Q86TC9