Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transporter activity	TRPM4 SPNS1 AQP12A SLC39A11 FLVCR1 TRPC5 TMC6 SLC6A19 SLC34A2 MFSD4A KCNK7 ABCA10 AQP12B C2CD2L IGF1R PRELID3A TMEM184A SLC20A2 SCN2B SLC37A2 DISP2 SLC45A1 TAP1 SLC25A17	5.99e-07	1289	120	24	GO:0005215
GeneOntologyMolecularFunction	transmembrane transporter activity	TRPM4 SPNS1 AQP12A SLC39A11 FLVCR1 TRPC5 TMC6 SLC6A19 SLC34A2 MFSD4A KCNK7 ABCA10 AQP12B SLC20A2 SCN2B SLC37A2 DISP2 SLC45A1 TAP1 SLC25A17	2.36e-05	1180	120	20	GO:0022857
GeneOntologyMolecularFunction	valine-tRNA ligase activity	VARS2 VARS1	3.58e-05	2	120	2	GO:0004832
GeneOntologyMolecularFunction	serine-type carboxypeptidase activity	CTSA PRCP	3.54e-04	5	120	2	GO:0004185
GeneOntologyMolecularFunction	insulin binding	C2CD2L IGF1R	3.54e-04	5	120	2	GO:0043559
GeneOntologyMolecularFunction	phosphate transmembrane transporter activity	SLC34A2 SLC20A2 SLC37A2	3.91e-04	24	120	3	GO:0005315
HumanPheno	Progressive	PNPLA2 SGCA FLVCR1 NAGLU SLC34A2 POMT1 CLPB MTMR14 SLC20A2 CPT1C KBTBD13 GNAS VARS1	1.33e-05	430	40	13	HP:0003676
Domain	Valyl-tRNA_ligase	VARS2 VARS1	3.89e-05	2	117	2	IPR002303
Domain	Anticodon_Ia_Val	VARS2 VARS1	3.89e-05	2	117	2	IPR033705
Domain	Aquaporin_12	AQP12A AQP12B	3.89e-05	2	117	2	IPR023265
Domain	Aquaporin_11/12	AQP12A AQP12B	1.16e-04	3	117	2	IPR016697
Domain	MFS_1	SPNS1 FLVCR1 MFSD4A SLC37A2 SLC45A1	1.22e-04	77	117	5	PF07690
Domain	MFS	SPNS1 FLVCR1 MFSD4A SLC37A2 SLC45A1	1.22e-04	77	117	5	IPR011701
Domain	Val/Leu/Ile-tRNA-synth_edit	VARS2 VARS1	5.74e-04	6	117	2	IPR009008
Domain	Anticodon_1	VARS2 VARS1	5.74e-04	6	117	2	PF08264
Domain	M/V/L/I-tRNA-synth_anticd-bd	VARS2 VARS1	5.74e-04	6	117	2	IPR013155
Domain	-	VARS2 VARS1	5.74e-04	6	117	2	3.90.740.10
Domain	aa-tRNA-synth_Ia	VARS2 VARS1	8.00e-04	7	117	2	IPR002300
Domain	tRNA-synt_1	VARS2 VARS1	8.00e-04	7	117	2	PF00133
Domain	-	VARS2 VARS1	2.06e-03	11	117	2	1.10.730.10
Domain	AAA+_ATPase	RNF213 FIGN ABCA10 CLPB TAP1	2.13e-03	144	117	5	IPR003593
Domain	AAA	RNF213 FIGN ABCA10 CLPB TAP1	2.13e-03	144	117	5	SM00382
Domain	SSD	DISP3 DISP2	2.90e-03	13	117	2	IPR000731
Domain	SSD	DISP3 DISP2	2.90e-03	13	117	2	PS50156
Domain	MIP	AQP12A AQP12B	3.37e-03	14	117	2	PS00221
Domain	MIP	AQP12A AQP12B	3.37e-03	14	117	2	PF00230
Domain	MIP	AQP12A AQP12B	3.87e-03	15	117	2	IPR000425
Domain	-	AQP12A AQP12B	3.87e-03	15	117	2	1.20.1080.10
Domain	Aquaporin-like	AQP12A AQP12B	3.87e-03	15	117	2	IPR023271
Domain	tRNAsynth_Ia_anticodon-bd	VARS2 VARS1	3.87e-03	15	117	2	IPR009080
Domain	MFS	SPNS1 FLVCR1 MFSD4A SLC37A2	4.75e-03	108	117	4	PS50850
Domain	TBC_RABGAP	TBC1D19 TBC1D8 TBC1D32	4.96e-03	55	117	3	PS50086
Domain	Rab-GTPase-TBC_dom	TBC1D19 TBC1D8 TBC1D32	4.96e-03	55	117	3	IPR000195
Domain	aa-tRNA-synth_I_CS	VARS2 VARS1	5.58e-03	18	117	2	IPR001412
Domain	AA_TRNA_LIGASE_I	VARS2 VARS1	6.21e-03	19	117	2	PS00178
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TRPM4 PNPLA2 LRFN1 GBF1 TMC6 NAGLU OBSCN ADCY9 C2CD2L IGF1R ARAP3 MTMR14 RPTOR DISP2 TNKS1BP1 WDR90 SLC45A1 ARRDC2 HTT	1.45e-08	1105	124	19	35748872
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	TRPM4 SPNS1 GPAA1 ASPHD1 HTR6 TMC6 CNTNAP1 MFSD4A CTSA TTC4 SLC20A2 GNAS TAP1 HTT	2.12e-07	697	124	14	28298427
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	TRPM4 PNPLA2 SPNS1 LRFN1 GBF1 GPAA1 TMEM41A RNF213 POMT1 ADCY9 BLM TBC1D8 C6orf120 TMEM164 SLC45A1	6.01e-06	1061	124	15	33845483
Pubmed	Identification of Serhl, a new member of the serine hydrolase family induced by passive stretch of skeletal muscle in vivo.	SERHL2 SERHL	1.26e-05	2	124	2	11352564
Pubmed	mTORC1 restrains adipocyte lipolysis to prevent systemic hyperlipidemia.	PNPLA2 RPTOR	1.26e-05	2	124	2	32029223
Pubmed	Genetic analysis of the aquaporin water channels AQP12A and AQP12B in patients with chronic pancreatitis.	AQP12A AQP12B	1.26e-05	2	124	2	36167651
Pubmed	Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells.	AQP12A AQP12B	1.26e-05	2	124	2	15809071
Pubmed	Cryo-EM structure of activated bile acids receptor TGR5 in complex with stimulatory G protein.	GPBAR1 GNAS	1.26e-05	2	124	2	32747649
Pubmed	Pancreas-specific aquaporin 12 null mice showed increased susceptibility to caerulein-induced acute pancreatitis.	AQP12A AQP12B	1.26e-05	2	124	2	19726746
Pubmed	Absence of GNAS and EGFL6 mutations in common human cancers.	EGFL6 GNAS	1.26e-05	2	124	2	18038328
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	TBC1D19 TRPM4 FLVCR1 TMC6 OBSCN RNF213 POMT1 PLBD2 ITFG1 IGF1R TMEM242 TMEM184A RPTOR GNAS CFAP69 RPS6KL1 HTT	2.25e-05	1489	124	17	28611215
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	GPAA1 CNTNAP1 NAGLU RNF213 POMT1 CTSA PLBD2 ITFG1 IGF1R PRCP CHSY3 TNKS1BP1 TMEM164 TAP1 HTT	2.57e-05	1201	124	15	35696571
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	AMFR GBF1 GPAA1 ZNF473 SLC39A11 CNTNAP1 ITFG1 EFTUD2 BLM IGF1R IPO9 RPTOR C6orf120 GNAS TAP1	2.62e-05	1203	124	15	29180619
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	AMFR TNC CNTNAP1 ADCY9 C2CD2L RPTOR TNKS1BP1 HTT	3.65e-05	347	124	8	17114649
Pubmed	Hedgehog signaling pathway and gastric cancer.	DISP3 DISP2	3.77e-05	3	124	2	16258256
Pubmed	Rab18 regulates lipolysis via Arf/GBF1 and adipose triglyceride lipase.	PNPLA2 GBF1	3.77e-05	3	124	2	31610914
Pubmed	SIX1 and SIX4 homeoproteins regulate PAX7+ progenitor cell properties during fetal epaxial myogenesis.	TNC SIX4 EFNA4	5.61e-05	21	124	3	32591430
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	CNTNAP1 NAGLU CTSA TTC4 PLBD2 ITFG1 IGF1R PRCP TIMM50 VARS1	7.26e-05	613	124	10	22268729
Pubmed	Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter.	RPTOR SLC37A2	7.53e-05	4	124	2	36170813
Pubmed	Differences between germ-line and rearranged immunoglobulin V kappa coding sequences suggest a localized mutation mechanism.	IGKV6D-21 IGKV6-21	7.53e-05	4	124	2	6264318
Pubmed	Dual Roles of Mammalian Target of Rapamycin in Regulating Liver Injury and Tumorigenesis in Autophagy-Defective Mouse Liver.	ATG5 RPTOR	7.53e-05	4	124	2	31095752
Pubmed	Podocytes maintain high basal levels of autophagy independent of mtor signaling.	ATG5 RPTOR	7.53e-05	4	124	2	31865844
Pubmed	High-protein diets increase cardiovascular risk by activating macrophage mTOR to suppress mitophagy.	ATG5 RPTOR	7.53e-05	4	124	2	32128508
Pubmed	Exome sequencing in seven families and gene-based association studies indicate genetic heterogeneity and suggest possible candidates for fibromuscular dysplasia.	OBSCN RNF213	7.53e-05	4	124	2	26147384
Pubmed	FGF19 and FGFR4 promotes the progression of gallbladder carcinoma in an autocrine pathway dependent on GPBAR1-cAMP-EGR1 axis.	GPBAR1 FGF19	7.53e-05	4	124	2	34163030
Pubmed	A nonautophagic role of ATG5 in regulating cell growth by targeting c-Myc for proteasome-mediated degradation.	ATG5 SKP2	7.53e-05	4	124	2	34755101
Pubmed	Analysis of t(9;17)(q33.2;q25.3) chromosomal breakpoint regions and genetic association reveals novel candidate genes for bipolar disorder.	RNF213 RPTOR	7.53e-05	4	124	2	25053281
Pubmed	Conditional mutagenesis in mice with heat shock promoter-driven cre transgenes.	IGF1R HTT	7.53e-05	4	124	2	10723724
Pubmed	Huntingtin interacts with the cue domain of gp78 and inhibits gp78 binding to ubiquitin and p97/VCP.	AMFR HTT	7.53e-05	4	124	2	20126661
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	ASPHD1 SLC39A11 SERHL OBSCN POMT1 TNFRSF12A PRELID3A TMEM242 TMEM184A AGFG2 TNKS1BP1 IL4I1 RPS6KL1	7.58e-05	1021	124	13	26760575
Pubmed	Interaction between the triglyceride lipase ATGL and the Arf1 activator GBF1.	PNPLA2 GBF1	1.25e-04	5	124	2	21789191
Pubmed	Genetic associations with hypertension: meta-analyses of six candidate genetic variants.	HSD3B1 GNAS	1.25e-04	5	124	2	23859711
Pubmed	TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations.	TRPM4 TRPC5	1.87e-04	6	124	2	32414784
Pubmed	Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M.	ATG5 GBF1	2.62e-04	7	124	2	28389568
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	TNC NAGLU CTSA ITFG1 PRCP	3.14e-04	164	124	5	32409323
Pubmed	A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.	PNPLA2 GBF1 SLC34A2 TTC4 SKP2 CLPB TIMM50	3.37e-04	363	124	7	25036637
Pubmed	A protein quality control pathway regulated by linear ubiquitination.	RNF31 HTT	3.48e-04	8	124	2	30886048
Pubmed	Characterization of placental endocrine function and fetal brain development in a mouse model of small for gestational age.	IGF1R ASCL2 HSD3B1	3.97e-04	40	124	3	36843585
Pubmed	The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy.	ATG5 HTT	4.47e-04	9	124	2	20417604
Pubmed	Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.	ADCY9 GNAS	4.47e-04	9	124	2	9417641
Pubmed	Molecular characterization of ENU mouse mutagenesis and archives.	BLM HTT	4.47e-04	9	124	2	16139793
Pubmed	MHC class Ib-restricted CTL provide protection against primary and secondary Listeria monocytogenes infection.	BLM TAP1	4.47e-04	9	124	2	11046052
Pubmed	Expression of Phosphate Transporters during Dental Mineralization.	SLC34A2 SLC20A2	4.47e-04	9	124	2	28892649
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	GBF1 SLC39A11 RNF213 IPO9 TIMM50	5.19e-04	183	124	5	23956138
Pubmed	The TRAF2-p62 axis promotes proliferation and survival of liver cancer by activating mTORC1 pathway.	RNF31 RPTOR	5.57e-04	10	124	2	37081115
Pubmed	BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.	FCHO2 PLBD2 MTMR14 TIMM50 AGFG2 HTT	5.72e-04	285	124	6	34369648
Pubmed	mTORC1 activity is essential for erythropoiesis and B cell lineage commitment.	KLF1 RPTOR	6.79e-04	11	124	2	31729420
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	GPAA1 CNTNAP1 NAGLU RNF213 VARS2 CTSA PLBD2 EFTUD2 CPT1C TIMM50 GNAS TAP1 SLC25A17 VARS1	6.84e-04	1451	124	14	30550785
Pubmed	Multiplicity of mechanisms of serotonin receptor signal transduction.	HTR6 GNAS	8.13e-04	12	124	2	11916537
Pubmed	TNAP limits TGF-β-dependent cardiac and skeletal muscle fibrosis by inactivating the SMAD2/3 transcription factors.	SGCA TNC	8.13e-04	12	124	2	31289197
Pubmed	Expression of adenylyl cyclase mRNAs in the denervated and in the developing mouse skeletal muscle.	ADCY9 GNAS	8.13e-04	12	124	2	9611134
Pubmed	Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1.	SKP2 RPTOR	9.59e-04	13	124	2	26051179
Pubmed	ULK1 inhibits the kinase activity of mTORC1 and cell proliferation.	ATG5 RPTOR	9.59e-04	13	124	2	21795849
Pubmed	Defining the membrane proteome of NK cells.	AMFR GBF1 GPAA1 RNF213 CTSA CCDC88B EFTUD2 IPO9 AGFG2 GNAS TAP1 SLC25A17	9.82e-04	1168	124	12	19946888
Pubmed	FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells.	NSUN4 TTC4 IPO9 CLPB GNAS	1.00e-03	212	124	5	33462405
Pubmed	HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.	VARS2 TTC4 EFTUD2 CLPB RPTOR TIMM50 GNAS VARS1	1.05e-03	571	124	8	37167062
Pubmed	Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.	ZNF473 DCUN1D5 IPO9 RPTOR VARS1	1.07e-03	215	124	5	35973513
Pubmed	Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS.	VARS2 VARS1	1.12e-03	14	124	2	15779907
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	TRPM4 TMEM41A POMT1 ITFG1 TNFRSF12A TBC1D8 SPPL2A PRCP TMEM164	1.13e-03	719	124	9	35337019
Pubmed	Mouse mutant embryos lacking huntingtin are rescued from lethality by wild-type extraembryonic tissues.	ASCL2 HTT	1.28e-03	15	124	2	9502734
Pubmed	Functional redundancy of frizzled 3 and frizzled 6 in planar cell polarity control of mouse hair follicles.	SERHL2 SERHL	1.28e-03	15	124	2	30237242
Pubmed	Huntingtin functions as a scaffold for selective macroautophagy.	RPTOR HTT	1.28e-03	15	124	2	25686248
Pubmed	Aquaporins 8 and 9 as Possible Markers for Adult Murine Lacrimal Gland Cells.	AQP12A AQP12B	1.28e-03	15	124	2	34540996
Pubmed	Age-regulated function of autophagy in the mouse inner ear.	ATG5 IGF1R	1.28e-03	15	124	2	26235979
Pubmed	Muscle contraction is necessary to maintain joint progenitor cell fate.	WNT9A SIX4	1.28e-03	15	124	2	19460349
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PPM1D FLVCR1 NAGLU RNF213 SIX4 FCHO2 ADCY9 BLM IPO9 MTMR14 TIMM50	1.36e-03	1049	124	11	27880917
Pubmed	Elevated fibroblast growth factor 23 exerts its effects on placenta and regulates vitamin D metabolism in pregnancy of Hyp mice.	SLC34A2 SLC20A2	1.46e-03	16	124	2	24470103
Pubmed	K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.	AMFR NSUN4 ASPHD1 RNF31 RNF213 FCHO2 PLBD2 MTMR14	1.49e-03	604	124	8	38803224
Pubmed	Gene expression during sex determination reveals a robust female genetic program at the onset of ovarian development.	WNT9A TMEM184A	1.66e-03	17	124	2	16214126
Pubmed	Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones.	RNF31 TNKS1BP1	1.66e-03	17	124	2	12693554
Pubmed	Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance.	AQP12A AQP12B	1.66e-03	17	124	2	26847765
Pubmed	Human myeloperoxidase in innate and acquired immunity.	IGKV6D-21 IGKV6-21	1.86e-03	18	124	2	20399194
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	GBF1 ZNF473 RNF213 VARS2 EFTUD2 IPO9 DISP3	2.00e-03	493	124	7	15368895
Pubmed	Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus.	GPBAR1 HTR6 GNAS	2.03e-03	70	124	3	12036966
Pubmed	Expression patterns of the aquaporin gene family during renal development: influence of genetic variability.	AQP12A AQP12B	2.07e-03	19	124	2	19367412
Pubmed	Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring.	ADCY9 GNAS	2.07e-03	19	124	2	20459687
Pubmed	Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.	AMFR TRPM4 SPNS1 GPAA1 CNTNAP1 TIMM50 TAP1	2.14e-03	499	124	7	22810586
Pubmed	Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation.	FIGN IPO9	2.30e-03	20	124	2	12447396
Pubmed	Characteristics of the immunoglobulin Vkappa genes, pseudogenes, relics and orphons in the mouse genome.	IGKV6D-21 IGKV6-21	2.30e-03	20	124	2	10427970
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	NSUN4 SPNS1 GPAA1 DCUN1D5 CNTNAP1 CTSA PLBD2 PRCP TNKS1BP1 IAH1 GNAS TAP1	2.36e-03	1297	124	12	33545068
Pubmed	EEF1D Promotes Glioma Proliferation, Migration, and Invasion through EMT and PI3K/Akt Pathway.	TNKS1BP1 VARS1	2.53e-03	21	124	2	33029523
Pubmed	Limb-Girdle Muscular Dystrophy Overview – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	SGCA POMT1	2.53e-03	21	124	2	20301582
Pubmed	The molecular and cellular signatures of the mouse eminentia thalami support its role as a signalling centre in the developing forebrain.	WNT9A FGF19	2.53e-03	21	124	2	26459142
Pubmed	Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis.	GBF1 OBSCN RPTOR TIMM50	2.58e-03	159	124	4	31332168
Pubmed	The imprinted Phlda2 gene regulates extraembryonic energy stores.	IGF1R ASCL2	2.78e-03	22	124	2	19884348
Pubmed	Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development.	SIX4 HSD3B1	2.78e-03	22	124	2	23987514
Pubmed	WNT4 and RSPO1 together are required for cell proliferation in the early mouse gonad.	IGF1R TMEM184A	2.78e-03	22	124	2	23095882
Pubmed	Nrf2 signalling and autophagy are involved in diabetes mellitus-induced defects in the development of mouse placenta.	ATG5 ASCL2	2.78e-03	22	124	2	27383629
Pubmed	ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.	ATG5 RNF213 EFTUD2 TIMM50 TAP1	2.80e-03	268	124	5	33024031
Pubmed	Identification and characterisation of imprinted genes in the mouse.	ASCL2 GNAS	3.04e-03	23	124	2	15163367
Pubmed	Hereditary Dystonia Overview	SLC6A19 SLC20A2 HTT	3.19e-03	82	124	3	20301334
Pubmed	A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.	SPNS1 GBF1 DCUN1D5 TTC4 PLBD2 MTMR14 RPTOR TNKS1BP1	3.27e-03	686	124	8	28380382
Pubmed	Mapping the expression of transient receptor potential channels across murine placental development.	TRPM4 TRPC5	3.31e-03	24	124	2	33884443
Pubmed	Brugada Syndrome	TRPM4 SCN2B	3.31e-03	24	124	2	20301690
Interaction	COQ8B interactions	COQ5 P2RY8 MFSD4A IGF1R EFNA4 CLPB TIMM50	3.60e-06	110	117	7	int:COQ8B
GeneFamily	Solute carriers	SLC39A11 FLVCR1 SLC6A19 SLC34A2 SLC20A2 SLC37A2 SLC45A1 SLC25A17	3.55e-04	395	80	8	752
GeneFamily	Dolichyl D-mannosyl phosphate dependent mannosyltransferases\|Phosphatidylinositol glycan anchor biosynthesis	POMT1 PIGZ	6.82e-04	9	80	2	430
GeneFamily	Aquaporins	AQP12A AQP12B	1.70e-03	14	80	2	305
Disease	combined oxidative phosphorylation deficiency 20 (implicated_via_orthology)	VARS2 VARS1	1.53e-05	2	116	2	DOID:0111478 (implicated_via_orthology)
Disease	polycystic kidney disease (biomarker_via_orthology)	GPBAR1 TNC GNAS	5.48e-05	19	116	3	DOID:0080322 (biomarker_via_orthology)
Disease	myoclonic-atonic epilepsy (implicated_via_orthology)	VARS2 VARS1	3.18e-04	7	116	2	DOID:0060475 (implicated_via_orthology)
Disease	mitochondrial encephalomyopathy (implicated_via_orthology)	VARS2 VARS1	4.22e-04	8	116	2	DOID:890 (implicated_via_orthology)
Disease	3-Methylglutaconic aciduria	CLPB TIMM50	4.22e-04	8	116	2	cv:C3696376
Disease	Moyamoya disease	WNT9A RNF213 RPTOR	5.26e-04	40	116	3	MONDO_0016820
Disease	partial epilepsy	ADCY9 TBC1D32	2.00e-03	17	116	2	EFO_0004263
Disease	muscular dystrophy (is_implicated_in)	SGCA POMT1	2.00e-03	17	116	2	DOID:9884 (is_implicated_in)
Disease	Headache	RNF213 DDX10 CHSY3	2.07e-03	64	116	3	HP_0002315
Disease	X-11470 measurement	VARS2 VARS1	2.51e-03	19	116	2	EFO_0021241
Disease	urate measurement	SPNS1 VARS2 TBC1D8 IGF1R SPPL2A SLC20A2 CPT1C GNAS FGF19 VARS1	2.83e-03	895	116	10	EFO_0004531
Disease	aspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement	ASPHD1 SLC39A11 ADCY9 IPO9 RPTOR HTT	3.22e-03	364	116	6	EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Disease	triacylglycerol 58:9 measurement	GBF1 SLC39A11	3.36e-03	22	116	2	EFO_0010443

Protein segments in the cluster

Peptide	Gene	Start	Entry
LSDLLLTSRAAAPGW	GNAS	226	P84996
WSLAALASFLPLLLG	HTR6	151	P50406
AALGLWSLYLAPLES	DISP3	611	Q9P2K9
TWDLTGLLLFSRLGD	CNTNAP1	391	P78357
SLALPLLLSWVAGGF	EGFL6	6	Q8IUX8
FTADRLTPLLSGWLD	ARAP3	281	Q8WWN8
WAGDFGPDLLLTLLF	AQP12A	51	Q8IXF9
GPRLRDFLSGSLATW	CCDC88B	6	A6NC98
GRAAPWTTALLLLLA	C6orf120	6	Q7Z4R8
LSLGWVLSLLSPFAF	ABCA10	266	Q8WWZ4
FSRLLTSAFLWLPRL	TBC1D32	1091	Q96NH3
FGLRLDSRWSFPLSL	HSD3B1	276	P14060
TSDLLAWDPLFGPSL	FCHO2	421	Q0JRZ9
WAGDFGPDLLLTLLF	AQP12B	51	A6NM10
LFDLLASSSALPWNI	ATG5	86	Q9H1Y0
FSASGPEAQRWLLAL	DISP2	801	A7MBM2
LALLLGRTWPLFSVF	DCUN1D5	166	Q9BTE7
ASFLLDWRLGALPER	ARRDC2	321	Q8TBH0
VFEAWRLLLTSAPSL	NAGLU	536	P54802
LSPAERELLDFSSWL	ASCL2	176	Q99929
SSLPDRWIILGAFIL	RAET1E	221	Q8TD07
RPGTFGSNLLTLWLF	RTN4RL2	76	Q86UN3
RGFFLLSILLGTPWE	PCDHGA7	11	Q9Y5G6
GTWLLLLTALSPLAR	P2RY8	146	Q86VZ1
PLESALSFTIRLLEW	PNPLA2	341	Q96AD5
EVLWPVLRSDAFSGL	FIGN	501	Q5HY92
TSPAATLLGSLFLWR	GPAA1	551	O43292
LPSLFWGFITLGRLL	MFSD4A	351	Q8N468
ISGWDRTPLFISLLR	MTMR14	331	Q8NCE2
LALLLTWAGPLLFAS	GPBAR1	126	Q8TDU6
LIGFLLLWVPASRGE	IGKV6-21	6	A0A0C4DH24
AALPFLLLLWAGASR	LRFN1	16	Q9P244
WPLPLASSALTLLFG	ASPHD1	71	Q5U4P2
EGRTWDLPSALLFAA	KCNK7	86	Q9Y2U2
LLFLSAALSLWPTSG	IGF1R	16	P08069
GISALWNGTFPSLLL	SLC25A17	161	O43808
DSIWFRPTLLQDSGL	IL1RAPL1	101	Q9NZN1
LIGFLLLWVPASRGE	IGKV6D-21	6	A0A0A0MT36
LLRTVLWAAFLGSPL	EFNA4	6	P52798
LWLAVAGRPLAFSDA	FGF19	16	O95750
WVLPSADLAARLLTS	RASGRP4	91	Q8TDF6
LSFLAPWATIALRPA	PRCP	11	P42785
PLSFTISRGFWVLLS	GDPD3	196	Q7L5L3
IPFLAVARALGDLWS	PPM1D	266	O15297
LEGPLRLSCAASWFT	IGHV8-51-1	31	P0DTE2
SALLWPRLLLFGDSI	IAH1	11	Q2TAA2
FGDLWPSIRVSLLSE	NSUN4	56	Q96CB9
PGLASFRLSGLKSWD	OBSCN	7446	Q5VST9
LELPDSSRALLLGWV	F2RL3	61	Q96RI0
LLLLVSWASRGEAAP	CTSA	16	P10619
VWSLRLLPALAGALS	POMT1	101	Q9Y6A1
LTGVFPASPLSWLFL	CPT1C	51	Q8TCG5
SRDSWFRGLILLLTF	SLC37A2	16	Q8TED4
WLEFLSFLLSPLELS	EEF1AKMT4-ECE2	461	P0DPD8
LTLLSSAWFPLDLSA	HTT	1071	P42858
SSLRSLWGRLLLQPS	IGLL5	61	B9A064
ATWDLDLLLTNFSGP	KLF1	71	Q13351
ASLLGSLWRYRPDSL	BLM	421	P54132
EGLLISWAFTDRPDL	C2CD2L	201	O14523
WLFLPSSLLAAATLA	GPR148	51	Q8TDV2
RWAGVSLDQSALLPL	ADCY9	701	O60503
SFLEPWLGDGLLLSA	CYP4F2	126	P78329
IFPATWLLDTRGLRL	FLVCR1	161	Q9Y5Y0
TFWPSGLLRLRLDSL	FRMD6-AS1	271	P0C7T7
LLGLRSSWPGDLLSA	COQ5	26	Q5HYK3
LNLSVSPFLLGRALW	IPO9	486	Q96P70
LSPLLSLSTFAALWL	GBF1	1631	Q92538
TSALEFRRWLGLPAG	CLPB	231	Q9H078
ARWDTLEPLDTGLSL	DDX10	846	Q13206
SLASFPQLDWGSALL	ETV2	56	O00321
DPSGQLLFRSSEILW	CFAP69	251	A5D8W1
WLDNASSFDRLIPLL	SERHL2	41	Q9H4I8
WQLIASFLRLPISGT	SLC20A2	101	Q08357
LAVSLPLRGAGFSTW	SLC39A11	246	Q8N1S5
LGFLLQPLLGAWSDR	SLC45A1	166	Q9Y2W3
LWRARGFLSSDGAPL	NYNRIN	1391	Q9P2P1
WDLLPRALLSSLSGL	IL4I1	266	Q96RQ9
SSWRLSQPSFLLVGI	OR52L1	21	Q8NGH7
WLDNASSFDRLIPLL	SERHL	41	Q9NQF3
VLDTWFSSGLFPLSI	VARS1	786	P26640
PLSLLETGSDLLLFW	VARS2	611	Q5ST30
WLSLLDSYAGSIPLL	SLC6A19	481	Q695T7
SLWFPSDLAELRELS	TMEM41A	41	Q96HV5
PWLFLTSALARGVSG	TMEM184A	46	Q6ZMB5
SLRLLSTEWGLPSLV	PRELID3A	51	Q96N28
LDRLARFLWSLPQSD	SIX4	126	Q9UIU6
ALPGLALFRELISWG	TAP1	106	Q03518
STPASRFLSALGGLW	SGCA	151	Q16586
DLLGRFLDLGPWAVS	RPTOR	451	Q8N122
WPSLRTYTGLSGLAL	AMFR	11	Q9UKV5
WLGLFDARTSLVPDS	AGFG2	111	O95081
LVLGFTAASWLIAPR	CHSY3	16	Q70JA7
SLLLLPAFSGLTWAP	RPP38-DT	116	Q8N326
PLTVFGLSLAGWRVL	SLC34A2	541	O95436
YALPSWGRAELALSL	RNF31	651	Q96EP0
SWDSLPDELLLGIFS	SKP2	96	Q13309
LSIDEPLFRSWFSLL	RNF213	751	Q63HN8
WLPRPAFSLTGLSLF	SCN2B	6	O60939
NLFLGSLTSRLWPRS	TIMM50	336	Q3ZCQ8
LRLWPLDFSSVLLEA	WDR90	641	Q96KV7
SWASLATLALFRLVP	TLCD2	166	A6NGC4
AWRTLAALPLEASTL	KBTBD13	186	C9JR72
EPLSSFRWALLSTGL	TMEM164	201	Q5U3C3
VTGSLALWAPAFLLR	SPNS1	286	Q9H2V7
IPESLRGRLWLLFSD	TBC1D8	506	O95759
RLSPAGAALLWGFLL	SPPL2A	6	Q8TCT8
LASPDRLWGSRLTFN	TNKS1BP1	176	Q9C0C2
LLVSDATPDGFRLSW	TNC	1626	P24821
RATPWFLTSLGRAAL	TMEM44	291	Q2T9K0
EWLSRPAASLLTELL	RPS6KL1	501	Q9Y6S9
RSVLFPLLISGSTFW	PIGZ	91	Q86VD9
PLARWLAAAFGLTLL	WNT9A	6	O14904
RLLWPILGGALSLTF	TNFRSF12A	76	Q9NP84
LLGNFVRSAWPSLRL	TMC6	116	Q7Z403
LSSEDPILTAFRLGW	TRPC5	211	Q9UL62
ARILSLLAASGPTWD	PLBD2	541	Q8NHP8
RLPSSWALFSPLLAG	ITFG1	6	Q8TB96
LLAARSIWAFGPDAT	EFTUD2	726	Q15029
LPESGSSLALRALGW	TMEM242	71	Q9NWH2
GSPTALRAELWALIL	TBC1D19	251	Q8N5T2
PSLRLIWDLAFLGSS	RARRES1	186	P49788
LSLDGQGRLSWPVLF	TTC4	266	O95801
LGWVAEALSRSALLP	TRPM4	1186	Q8TD43
WLDSLLGDPESLLRS	ZNF473	121	Q8WTR7