Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DNHD1 HOOK1 DNAH6	5.52e-05	28	53	3	GO:0051959
GeneOntologyMolecularFunction	cytoskeletal motor activity	DNHD1 KIF26A MYH7B DNAH6	2.71e-04	118	53	4	GO:0003774
Domain	Dynein_HC_stalk	DNHD1 DNAH6	7.03e-04	14	53	2	IPR024743
Domain	Dynein_heavy_dom-2	DNHD1 DNAH6	7.03e-04	14	53	2	IPR013602
Domain	DHC_N2	DNHD1 DNAH6	7.03e-04	14	53	2	PF08393
Domain	MT	DNHD1 DNAH6	7.03e-04	14	53	2	PF12777
Domain	DHC_fam	DNHD1 DNAH6	8.10e-04	15	53	2	IPR026983
Domain	Dynein_heavy_dom	DNHD1 DNAH6	8.10e-04	15	53	2	IPR004273
Domain	Dynein_heavy	DNHD1 DNAH6	8.10e-04	15	53	2	PF03028
Domain	Leu-rich_rpt_Cys-con_subtyp	RNH1 FBXL14	1.31e-03	19	53	2	IPR006553
Domain	LRR_CC	RNH1 FBXL14	1.31e-03	19	53	2	SM00367
Domain	SPRY	BTN1A1 HERC1 RYR2	1.93e-03	87	53	3	SM00449
Domain	SPRY	BTN1A1 HERC1 RYR2	2.41e-03	94	53	3	PF00622
Domain	SPRY_dom	BTN1A1 HERC1 RYR2	2.41e-03	94	53	3	IPR003877
Domain	B30.2/SPRY	BTN1A1 HERC1 RYR2	2.48e-03	95	53	3	IPR001870
Domain	B302_SPRY	BTN1A1 HERC1 RYR2	2.48e-03	95	53	3	PS50188
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	LRPPRC INTU HOOK1 ARMC3 MYH7B MYOM2 LIMCH1 DNAH6 TUFM RYR2	6.58e-05	1442	54	10	35575683
Pubmed	Real-time resolution of point mutations that cause phenovariance in mice.	JAK3 TP53BP1	1.06e-04	10	54	2	25605905
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	RNASEH2B LRPPRC TTLL3 ARHGEF7 MYH7B CD55 SLC25A29 HERC1 UBASH3A	1.15e-04	1242	54	9	30973865
Pubmed	A High-Density Map for Navigating the Human Polycomb Complexome.	RLF ARHGEF7 FBXL14 ASXL2 TUFM MXI1	1.17e-04	495	54	6	27705803
Pubmed	Quantitative interaction proteomics of neurodegenerative disease proteins.	LRPPRC RNH1 MYOM2 IPO4 TUFM	1.46e-04	323	54	5	25959826
Pubmed	hCOA3 stabilizes cytochrome c oxidase 1 (COX1) and promotes cytochrome c oxidase assembly in human mitochondria.	LRPPRC TUFM	1.55e-04	12	54	2	23362268
Pubmed	The reduction of oocytes and disruption of the meiotic prophase I in Fanconi anemia E-deficient mice.	FANCE TP53BP1	1.83e-04	13	54	2	35671285
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	RLF RNASEH2B TAF6L ALKBH8 SCAP RNH1 ARHGEF7 RIC8A UROS	1.89e-04	1327	54	9	32694731
Pubmed	The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.	TAF6L GLMN RNH1 LIMCH1 IPO4 TUFM	2.01e-04	547	54	6	37267103
Pubmed	Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis.	TAGAP UBASH3A	2.13e-04	14	54	2	20647273
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	RLF LRPPRC RNH1 CHTF18 RIC8A TAF2 IPO4 TUFM TP53BP1	2.18e-04	1353	54	9	29467282
Pubmed	Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis.	TAF6L TAF2	2.45e-04	15	54	2	12601814
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	ALKBH8 SCAP TTLL3 TAGAP CD55 ASXL2 HERC1 TP53BP1	2.53e-04	1084	54	8	11544199
Pubmed	JIP4 is a PLK1 binding protein that regulates p38MAPK activity in G2 phase.	TUFM TP53BP1	2.80e-04	16	54	2	26291670
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	TAF6L DNHD1 HOOK1 MYH7B	3.11e-04	208	54	4	33230847
Pubmed	Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.	LRPPRC RNH1 CHTF18 IPO4	3.28e-04	211	54	4	17314511
Pubmed	The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.	TAF6L RNH1 RIC8A IPO4 TP53BP1	3.91e-04	400	54	5	35013556
Pubmed	UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation.	TAF6L TAF2	4.42e-04	20	54	2	11406595
Pubmed	Shared and distinct genetic variants in type 1 diabetes and celiac disease.	TAGAP UBASH3A	4.88e-04	21	54	2	19073967
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	LRPPRC RNH1 MYH7B LIMCH1 IPO4 TP53BP1	4.90e-04	647	54	6	26618866
Pubmed	Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II.	GLMN RNH1 IPO4 TUFM	5.68e-04	244	54	4	30349055
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	GLMN LRPPRC SCAP HOOK1 RIC8A IPO4 TUFM	6.11e-04	942	54	7	31073040
Pubmed	Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.	RLF RIC8A TAF2 UROS TUFM	6.93e-04	454	54	5	33226137
Pubmed	ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.	DNHD1 TP53BP1	8.10e-04	27	54	2	17525332
Pubmed	DULIP: A Dual Luminescence-Based Co-Immunoprecipitation Assay for Interactome Mapping in Mammalian Cells.	RNH1 ARHGEF7 MXI1	8.32e-04	118	54	3	26264872
Pubmed	The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes.	TAF6L TAF2	8.72e-04	28	54	2	19114550
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	TAF6L LRPPRC RNH1 ASXL2 TYSND1 IPO4 TP53BP1	8.94e-04	1005	54	7	19615732
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	TAF6L LRPPRC INTU HOOK1 RNH1 SLC25A29 IPO4 TP53BP1	9.33e-04	1321	54	8	27173435
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	TAF6L RNH1 TAF2 IPO4	9.73e-04	282	54	4	23667531
Pubmed	A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.	TAF6L TAF2	1.00e-03	30	54	2	18206972
Pubmed	Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk.	FANCE TP53BP1	1.07e-03	31	54	2	19690177
Pubmed	Absence of canonical Smad signaling in ureteral and bladder mesenchyme causes ureteropelvic junction obstruction.	KIF26A MYOM2	1.07e-03	31	54	2	22282597
Pubmed	The layered structure of human mitochondrial DNA nucleoids.	LRPPRC TUFM	1.14e-03	32	54	2	18063578
Pubmed	Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.	TAF6L TAF2	1.21e-03	33	54	2	11564863
Pubmed	Functional analysis and identification of cis-regulatory elements of human chromosome 21 gene promoters.	ADAMTS5 UBASH3A	1.29e-03	34	54	2	20494980
Pubmed	DSSylation, a novel protein modification targets proteins induced by oxidative stress, and facilitates their degradation in cells.	TAF2 DNAH6	1.36e-03	35	54	2	24515614
Pubmed	LINC01554-Mediated Glucose Metabolism Reprogramming Suppresses Tumorigenicity in Hepatocellular Carcinoma via Downregulating PKM2 Expression and Inhibiting Akt/mTOR Signaling Pathway.	LRPPRC IPO4 TUFM	1.42e-03	142	54	3	30809309
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	CCDC142 JAK3 SCAP KIF26A FBXL14 RIC8A HERC1	1.54e-03	1105	54	7	35748872
CoexpressionAtlas	MESO-30 amniotic fluid MSC_vs_MESO-30 blastocyst-Confounder_removed-fold2.0_adjp0.05	RLF TAF6L GLMN LRPPRC INTU HOOK1 KIF26A CHTF18 FBXL14 LIMCH1 IPO4 SLC15A3 SEC31B MXI1	1.47e-06	1245	53	14	PCBC_ratio_MESO-30 amniotic fluid MSC_vs_MESO-30 blastocyst_cfr-2X-p05
CoexpressionAtlas	DevelopingGonad_e18.5_ovary_emap-12283_k-means-cluster#5_top-relative-expression-ranked_1000	HOOK1 ARHGEF7 GLIPR1L2 CD55 ASXL2 HERC1 RYR2	1.61e-06	230	53	7	gudmap_developingGonad_e18.5_ovary_1000_k5
CoexpressionAtlas	DevelopingGonad_e18.5_ovary_emap-12283_k-means-cluster#1_top-relative-expression-ranked_200	ARHGEF7 GLIPR1L2 CD55 RYR2	6.74e-06	49	53	4	gudmap_developingGonad_e18.5_ovary_200_k1
Computational	Genes upregulated in subsets of cells of a given type within various tumors	CD55 LIMCH1 ADAMTS5	2.02e-04	48	26	3	GAVISH_3CA_METAPROGRAM_FIBROBLASTS_PI16_POS
Disease	salicylurate measurement	CHTF18 RYR2	2.26e-04	13	51	2	EFO_0010532
Disease	focal segmental glomerulosclerosis	IPO4 DNAH6	3.46e-04	16	51	2	EFO_0004236
Disease	mean corpuscular hemoglobin concentration	RNASEH2B INTU HOOK1 CHTF18 RIC8A ASXL2 MXI1	2.78e-03	1105	51	7	EFO_0004528
Disease	heel bone mineral density, urate measurement	ANKRD31 GRID2IP MYOM2	3.87e-03	182	51	3	EFO_0004531, EFO_0009270
Disease	free cholesterol to total lipids in medium VLDL percentage	ANKRD31 TP53BP1	4.40e-03	57	51	2	EFO_0022284
Disease	free cholesterol in very large VLDL measurement	ANKRD31 TP53BP1	5.02e-03	61	51	2	EFO_0022274
Disease	colorectal health	ARMC3 ADAMTS5 RYR2	5.10e-03	201	51	3	EFO_0008460

Protein segments in the cluster

Peptide	Gene	Start	Entry
ALCLLLDILAPKLRP	CHTF18	761	Q8WVB6
RCLLTLILLQLPKLD	BTN1A1	11	Q13410
LLPVLEKCGLVDALL	ALKBH8	61	Q96BT7
CLLDLPRKQILGPEE	ADAMTS5	471	Q9UNA0
LDGALLCLLQQPLPK	CCDC142	641	Q17RM4
KDGVVLCRLLERLLP	ARHGEF7	36	Q14155
LCRLLERLLPGTIEK	ARHGEF7	41	Q14155
GTKLLPLKELCLQEP	ARMC3	581	Q5W041
PCRLPLLKQILEDTI	DNHD1	1871	Q96M86
RDLDCLLQQLKGAPP	DNHD1	4501	Q96M86
PGDCQQRLLLLLPEV	ASXL2	296	Q76L83
KACLPPSLRDLIQGL	JAK3	191	P52333
ALPLLFPCGNLKREI	UROS	136	P10746
EDRLGKQCLLLPLLL	PCDHA6	6	Q9UN73
CIQIKDLILLGRINP	ANKRD31	1696	Q8N7Z5
LPLAVGGVLKLRLCE	GLIPR1L2	16	Q4G1C9
PLDCLNRLLPAADLL	HERC1	1091	Q15751
GELPRLLLLVLLCLP	CD55	16	P08174
DLQPCIDLIEKPLGI	MYH7B	561	A7E2Y1
LLRSCGSLLPELKLE	LRPPRC	126	P42704
RDPCLSALLLDKLPA	KIF26A	96	Q9ULI4
GLLRLLKAPALPLLC	TUFM	26	P49411
RITQLPCLKVLNLGL	FBXL14	376	Q8N1E6
CLLPLAAKQRIGQLI	INTU	546	Q9ULD6
EKLIPSPLRCLEVLN	DNAH6	681	Q9C0G6
ACGPLLDNLRIFIPK	GRID2IP	186	A4D2P6
CEPGDRLLVPKLLLA	SLC25A29	181	Q8N8R3
LGLLIIRCFKILLDP	CTXN2	41	P0C2S0
LQLPQLSDLGLLRLC	FANCE	331	Q9HB96
CSDPVELGRLLQLIL	HOOK1	111	Q9UJC3
ILCLGPSDLLVKLRL	GPR22	336	Q99680
DRLIDPLLLRCKLLP	SLC15A3	391	Q8IY34
LCLQVTDLLPGLRKL	SCAP	146	Q12770
LICDNLLPGRDLLLQ	RYR2	631	Q92736
LLPPLLQIVCKGLED	IPO4	391	Q8TEX9
GILLCELLNAIKPGL	LIMCH1	51	Q9UPQ0
DLLVKLCNPKELLLG	GLMN	91	Q92990
LCNPKELLLGLLELI	GLMN	96	Q92990
LSLQKILADPVRPLC	TAF6L	291	Q9Y6J9
DQALRLLPPQELCRK	PSAPL1	236	Q6NUJ1
PRPIQDILTILCLKG	TAGAP	101	Q8N103
CLPLPELGLVLNLKE	TAF2	986	Q6P1X5
LLLGELGPAVELCLK	SEC31B	571	Q9NQW1
VNLLGNLPLKCLDVL	RIC8A	276	Q9NPQ8
NLPLKCLDVLLTLEP	RIC8A	281	Q9NPQ8
PVPNSLRCELLLALK	RLF	446	Q13129
VFPNCILLLKLPGLE	RNASEH2B	121	Q5TBB1
LALPCKLTIPQRELG	TNS4	546	Q8IZW8
GLLDPQCRLEKLQLE	RNH1	136	P13489
DVLGKDILLCDPIPL	TP53BP1	1526	Q12888
KAPALLCLRGPQLEV	TTLL3	641	Q9Y4R7
IKDACQVLLLRLPPE	SLC30A5	641	Q8TAD4
LLGRLEKPLLLLCCA	TMEM139	6	Q8IV31
LQPRLPAELLLLLSC	TYSND1	126	Q2T9J0
LFLCPTGPLLEKLQE	UBASH3A	76	P57075
LDKLVLQGLLRLLEP	ATP6V1E2	116	Q96A05
CLERLKVLIPLGPDC	MXI1	86	P50539
PNLERGICELLIPKL	MYOM2	1176	P54296