Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
HumanPheno	Abnormal humerus morphology	PRKG2 GNPTAB KIAA0753	2.44e-05	17	18	3	HP:0031095
Domain	Spectrin	KALRN SYNE1	1.33e-03	23	44	2	PF00435
Domain	JmjC	PHF2 KDM6A	1.45e-03	24	44	2	PF02373
Domain	Spectrin_repeat	KALRN SYNE1	2.11e-03	29	44	2	IPR002017
Domain	JMJC	PHF2 KDM6A	2.57e-03	32	44	2	PS51184
Domain	Spectrin/alpha-actinin	KALRN SYNE1	2.57e-03	32	44	2	IPR018159
Domain	JmjC_dom	PHF2 KDM6A	2.57e-03	32	44	2	IPR003347
Domain	SPEC	KALRN SYNE1	2.57e-03	32	44	2	SM00150
Domain	JmjC	PHF2 KDM6A	2.73e-03	33	44	2	SM00558
Pubmed	PKC regulates the delta2 glutamate receptor interaction with S-SCAM/MAGI-2 protein.	MAGI2 GRID2	1.79e-06	2	47	2	12589829
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	DTNBP1 KALRN TRIM9 SYNE1 GNPTAB	1.91e-06	151	47	5	17043677
Pubmed	T Follicular Helper Cell-Dependent Clearance of a Persistent Virus Infection Requires T Cell Expression of the Histone Demethylase UTX.	KDM6A IL6R	5.36e-06	3	47	2	26431949
Pubmed	Chromosomal assignments of 23 biochemical loci of the rat by using rat x mouse somatic cell hybrids.	PPA1 GANC F5	9.15e-06	30	47	3	1914521
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	PHF2 TRIM9 SYNE1 TLN1 GNPTAB	1.33e-05	225	47	5	12168954
Pubmed	Expression of factor V by resident macrophages boosts host defense in the peritoneal cavity.	F5 TLN1	1.78e-05	5	47	2	31048328
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	PHF2 RECQL RCOR1 PPA1 F5 TLN1 KIAA0753	2.41e-05	645	47	7	25281560
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	MAGI2 ZNF350 LARP6 KALRN TRIM9 KDM6A SYNE1 HNRNPF GNPTAB	4.79e-05	1285	47	9	35914814
Pubmed	The human plasma proteome: a nonredundant list developed by combination of four separate sources.	MSH5 F5 ITIH2 IL6R	7.43e-05	165	47	4	14718574
Pubmed	DYRK3 phosphorylates SNAPIN to regulate axonal retrograde transport and neurotransmitter release.	MAGI2 ZNF350	7.99e-05	10	47	2	36585413
Pubmed	Inositol hexakisphosphate kinase 3 promotes focal adhesion turnover via interactions with dynein intermediate chain 2.	BCL11B IP6K2	9.75e-05	11	47	2	30718399
Pubmed	The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability.	ZNF350 SYNE1	9.75e-05	11	47	2	27621083
Pubmed	A murine model of hnRNPH2-related neurodevelopmental disorder reveals a mechanism for genetic compensation by Hnrnph1.	BCL11B HNRNPF	1.17e-04	12	47	2	37463454
Pubmed	Synopsis of preterm birth genetic association studies: the preterm birth genetics knowledge base (PTBGene).	F5 IL6R	1.38e-04	13	47	2	20484876
Pubmed	DeCoN: genome-wide analysis of in vivo transcriptional dynamics during pyramidal neuron fate selection in neocortex.	BCL11B DTNBP1	1.86e-04	15	47	2	25556833
Pubmed	Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D.	MAGI2 WDFY4	2.40e-04	17	47	2	22041458
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	MAGI2 RCOR1 BCL11B MDN1 ZNF394 KALRN SYNE1	2.92e-04	963	47	7	28671696
Pubmed	BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development.	BCL11B DTNBP1	3.01e-04	19	47	2	27719760
Pubmed	The Tbr2 Molecular Network Controls Cortical Neuronal Differentiation Through Complementary Genetic and Epigenetic Pathways.	BCL11B KDM6A	3.69e-04	21	47	2	27600842
Pubmed	Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.	RCOR1 MDN1 HNRNPF	4.05e-04	106	47	3	19394292
Pubmed	Putative complement control protein CSMD3 dysfunction impairs synaptogenesis and induces neurodevelopmental disorders.	LAMC3 BCL11B	4.06e-04	22	47	2	35245678
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	PHF2 RECQL LAMC3 PPA1 MDN1 SYNE1 HNRNPF TLN1	5.89e-04	1425	47	8	30948266
Pubmed	Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags.	DNAJC12 MSH5 F5 ITIH2 IP6K2	6.14e-04	510	47	5	16712791
Pubmed	Mapping the interactome of HPV E6 and E7 oncoproteins with the ubiquitin-proteasome system.	KLHL35 TRIM9 DDB2	8.72e-04	138	47	3	28786561
Pubmed	Ctip2 controls the differentiation of medium spiny neurons and the establishment of the cellular architecture of the striatum.	BCL11B NTS	9.19e-04	33	47	2	18199763
Pubmed	Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.	PHF2 KDM6A	9.19e-04	33	47	2	26864203
Pubmed	The ciliogenic transcription factor Rfx3 is required for the formation of the thalamocortical tract by regulating the patterning of prethalamus and ventral telencephalon.	BCL11B NKX6-2	9.75e-04	34	47	2	25631876
Pubmed	Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1.	B3GALT1 GANC	1.16e-03	37	47	2	2541446
Pubmed	Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport.	B3GALT1 GANC	1.16e-03	37	47	2	2542563
Pubmed	Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis.	B3GALT1 GANC	1.22e-03	38	47	2	2829950
Pubmed	Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1.	B3GALT1 GANC	1.22e-03	38	47	2	2187500
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	PHF2 RCOR1 BCL11B	1.26e-03	157	47	3	30186101
Pubmed	MTG8 interacts with LHX6 to specify cortical interneuron subtype identity.	BCL11B NKX6-2	1.28e-03	39	47	2	36064547
Pubmed	Identification and Functional Characterization of a Novel Androgen Receptor Coregulator, EAP1.	RCOR1 KDM6A	1.35e-03	40	47	2	34585037
GeneFamily	PHD finger proteins\|Lysine demethylases	PHF2 KDM6A	9.23e-04	24	34	2	485
ToppCell	COVID-19-Heart-T_cell\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GRID2 BCL11B MMD2 HS6ST3	3.16e-05	171	47	4	b2e753e811a7639956994609f73efcdb62d04f82
ToppCell	COVID_vent-Myeloid-Dendritic\|COVID_vent / Disease condition, Lineage, Cell class and subclass	PPA1 LACC1 WDFY4 IL6R	4.39e-05	186	47	4	63a5cdd3f60681762a218be32db84be8f29b88fd
ToppCell	COVID_vent-Myeloid-Dendritic-cDC\|COVID_vent / Disease condition, Lineage, Cell class and subclass	PPA1 LACC1 WDFY4 IL6R	4.39e-05	186	47	4	39457a7b43537f2c3e221f9375c95d4515424d7d
ToppCell	Endothelial-B-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	DTNBP1 ZNF99 KALRN NTS	4.58e-05	188	47	4	ecb74d67314a43b5805b7f2a7bb9ff6c5a60200a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LAMC3 MDN1 KALRN SYNE1	4.77e-05	190	47	4	1121eb607a984c59fbffe7220837fc178745aa55
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LAMC3 MDN1 KALRN SYNE1	4.77e-05	190	47	4	048b581e3f7ea9fc2f87c0532974bba85c7292c2
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMC3 GRID2 KALRN HS6ST3	4.87e-05	191	47	4	7b0d42a877540dbb346a76a62403e0d5d3e07fa6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMC3 GRID2 KALRN HS6ST3	4.87e-05	191	47	4	cd854b9c426924fdc84bf7f411f6dea447143e79
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Newborn-41\|World / Primary Cells by Cluster	DNAJC12 PPA1 HS6ST3 NTS	5.38e-05	196	47	4	dee0984cd63a1a2fdebb4421af48ab566a5b684e
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Deep_Layer-37\|World / Primary Cells by Cluster	DNAJC12 BCL11B HS6ST3 NTS	5.49e-05	197	47	4	00d756bc0231e1b3b88430214338c1059cb11106
ToppCell	T_cells-Treg_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	LAMC3 BCL11B F5 IL6R	5.49e-05	197	47	4	de5448fcdf4e433fc167496413abe5d0c8a5c6d8
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LAMC3 MDN1 KALRN SYNE1	5.60e-05	198	47	4	a860246bcea847249a78fd2e86ed8e04371060db
ToppCell	Sigmoid-(1)_T_cell-(14)_Tcm\|Sigmoid / shred on region, Cell_type, and subtype	BCL11B F5 SYNE1 OSGIN1	5.71e-05	199	47	4	ec454fa22fb7f50a947bdf4c4bb6f0ba13f62b4c
ToppCell	Caecum-T_cell-Activated_CD4_T\|T_cell / Region, Cell class and subclass	XRRA1 BCL11B DTNBP1 IL6R	5.71e-05	199	47	4	13173cc4dcc8e856680372b0a4ad4f36afa892c1
ToppCell	Sigmoid-T_cell-Tcm\|Sigmoid / Region, Cell class and subclass	BCL11B F5 SYNE1 OSGIN1	5.71e-05	199	47	4	f7c729eaa3c8fd5a05cb6f79cac9b8f199c8092b
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-2m-Neuronal-Neuron\|2m / Sample Type, Dataset, Time_group, and Cell type.	KLHL35 BCL11B KALRN IP6K2	5.82e-05	200	47	4	a581f1704a87b0390e1e2ff85053367d85247755
Drug	15d-PGJ2; Up 200; 10uM; MCF7; HT_HG-U133A_EA	ZNF350 LARP6 KDM6A IL6R IP6K2 OSGIN1	6.86e-07	159	45	6	1011_UP
Drug	Mimosine [500-44-7]; Up 200; 20.2uM; MCF7; HT_HG-U133A	MAGI2 ZNF350 BCL11B KDM6A ITIH2 IL6R	2.46e-06	198	45	6	2638_UP
Disease	revision of total knee arthroplasty	MAGI2 GRID2 IP6K2	8.99e-06	26	46	3	EFO_0020972
Disease	airway wall thickness measurement	MAGI2 BCL11B	1.55e-04	12	46	2	EFO_0006898
Disease	calcium/calmodulin-dependent protein kinase type 1 measurement	F5 IL6R	2.81e-04	16	46	2	EFO_0008062
Disease	Colorectal Carcinoma	GRID2 BCL11B KALRN F5 KDM6A SYNE1	7.40e-04	702	46	6	C0009402
Disease	cerebral infarction (is_implicated_in)	KALRN F5	9.40e-04	29	46	2	DOID:3526 (is_implicated_in)
Disease	diffuse plaque measurement	PHF2 MAGI2 BCL11B MMD2 DTNBP1 MMD2	1.10e-03	758	46	6	EFO_0010699

Protein segments in the cluster

Peptide	Gene	Start	Entry
MHRIWNDMSSKKHLR	B3GALT1	311	Q9Y5Z6
SVKTSMHWVVRGKKD	DNAJC12	96	Q9UKB3
SMLERHLSTHMWKKI	ATXN7L2	441	Q5T6C5
WKKTRTKTSVMDRHA	RCOR1	236	Q9UKL0
FHTISWKKSHLRMVE	MMD2	86	Q8IY49
TMKRHTEKSTKHWFS	MDN1	3826	Q9NU22
KKKSHWTSKVHESVI	MAGI2	6	Q86UL8
IANKWKTIHLIMHSG	GNPTAB	591	Q3T906
EMSFSVLLHRVWKKH	ITIH2	821	P19823
WVRQHRKEEKMKSHK	IP6K2	131	Q9UHH9
WMHHTVDLLGDKATK	KDM6A	251	O15550
NAFHKKLEDRKWHSM	GRID2	336	O43424
VMLSAHWEKKKTSLV	DTNBP1	81	Q96EV8
AAKQKVRSRTHVHWM	GANC	311	Q8TET4
SIKKSCSWHTLRMRK	KALRN	2396	O60229
IKTHHSNDIWIMGRK	LACC1	246	Q8IV20
KKVKHLTRDWRTTAH	LARP6	136	Q9BRS8
WNLRMHKKKVTHVAL	DDB2	236	Q92466
KHVQRGATWKTSLHM	HS6ST3	256	Q8IZP7
HAKRSMSNWKLSKAL	PRKG2	416	Q13237
RKSKWNHVVHKFVMC	FADS2B	226	A8MWK0
MHTSKISKAHVPSWK	NTS	41	P30990
TMEVVKHHSPVSWKR	APOBEC3F	221	Q8IUX4
TWKLRALKEGKTSMH	IL6R	391	P08887
KHMKKWHGEHLLTND	BCL11B	871	Q9C0K0
KSTHDHWKALVTKKT	PPA1	221	Q15181
GNMKSVLTWKHRKEH	OSGIN1	101	Q9UJX0
WLSKKHMIWINTTTH	MT-ND4	16	P03905
KRMKLSHTKVSDWQV	MSH5	321	O43196
FKSHRTEMDWVLKHS	HNRNPF	86	P52597
WKHRKKMQHTVKISG	TAS2R14	206	Q9NYV8
THGKSTLKKKRTWHK	PHF2	56	O75151
RATKEIQLHQMKKWH	SYNE1	3631	Q8NF91
SWMKLLAHKVGRHLS	F5	881	P12259
TKWRKRHAVEMASAK	NKX6-2	201	Q9C056
RTHHGASLWKMVKEI	RPL37AP8	16	A6NKH3
IKHTKKSWAMSKLAA	KIAA0753	291	Q2KHM9
SKEHVKWVHAEMVNK	RECQL	166	P46063
KWSSKLTVHKVIHME	ZNF99	491	A8MXY4
FQWSSKLTLHKVIHM	ZNF99	826	A8MXY4
KCKQSFHMVTWHVLK	ZNF394	316	Q53GI3
WRKNKMDESKHEIHS	TLN1	531	Q9Y490
QWHHLAVVVTKEMKR	WDFY4	1161	Q6ZS81
HEVKALGAMWKLHKS	TRIM9	261	Q9C026
IKKSWLTDHQVMHTG	ZNF350	216	Q9GZX5
KHLEVARTWHKLIKT	TTC37	131	Q6PGP7
HHVLMSRKESWKVKS	XRRA1	441	Q6P2D8
KVASLHKGRWRHKMA	KLHL35	376	Q6PF15
KAKALEKTVASWQHM	LAMC3	1271	Q9Y6N6