Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionbenzoate-CoA ligase activity

ACSM2A ACSM2B

4.74e-053802GO:0018858
GeneOntologyMolecularFunctionC-acyltransferase activity

ACAT1 ACSM2A ACSM2B

7.82e-0521803GO:0016408
GeneOntologyMolecularFunctiondecanoate-CoA ligase activity

ACSM2A ACSM2B

9.46e-054802GO:0102391
GeneOntologyMolecularFunctionfatty-acyl-CoA synthase activity

ACSM2A ACSM2B

4.37e-048802GO:0004321
GeneOntologyMolecularFunctionprotein-membrane adaptor activity

LPL SYNE2 ATG14

7.78e-0445803GO:0043495
GeneOntologyMolecularFunctionmedium-chain fatty acid-CoA ligase activity

ACSM2A ACSM2B

8.52e-0411802GO:0031956
DomainSpectrin

DST SPTAN1 SPTBN1 SYNE2

3.01e-0623834PF00435
DomainSpectrin_repeat

DST SPTAN1 SPTBN1 SYNE2

7.91e-0629834IPR002017
DomainSpectrin/alpha-actinin

DST SPTAN1 SPTBN1 SYNE2

1.19e-0532834IPR018159
DomainSPEC

DST SPTAN1 SPTBN1 SYNE2

1.19e-0532834SM00150
DomainNfI_DNAbd_pre-N

NFIB NFIC

1.16e-044832PF10524
DomainCTF_NFI

NFIB NFIC

1.16e-044832PF00859
DomainCTF_NFI_1

NFIB NFIC

1.16e-044832PS00349
DomainCTF/NFI

NFIB NFIC

1.16e-044832IPR000647
DomainCTF_NFI_2

NFIB NFIC

1.16e-044832PS51080
DomainCTF/NFI_DNA-bd_N

NFIB NFIC

1.16e-044832IPR019548
DomainCTF/NFI_DNA-bd_CS

NFIB NFIC

1.16e-044832IPR019739
DomainCTF/NFI_DNA-bd-dom

NFIB NFIC

1.16e-044832IPR020604
DomainActinin_actin-bd_CS

DST SPTBN1 SYNE2

1.41e-0423833IPR001589
DomainACTININ_2

DST SPTBN1 SYNE2

1.41e-0423833PS00020
DomainACTININ_1

DST SPTBN1 SYNE2

1.41e-0423833PS00019
DomainHSR

SP140L SP140

1.93e-045832PS51414
DomainHSR

SP140L SP140

1.93e-045832PF03172
DomainHSR_dom

SP140L SP140

1.93e-045832IPR004865
DomainSAND_dom

SP140L SP140

5.37e-048832IPR000770
DomainSAND

SP140L SP140

5.37e-048832PF01342
DomainSAND

SP140L SP140

5.37e-048832PS50864
DomainSAND

SP140L SP140

5.37e-048832SM00258
DomainMAD_homology1_Dwarfin-type

NFIB NFIC

1.25e-0312832IPR003619
DomainDWA

NFIB NFIC

1.25e-0312832SM00523
Domain-

SP140L SP140

1.25e-03128323.10.390.10
DomainSAND_dom-like

SP140L SP140

1.25e-0312832IPR010919
DomainMH1

NFIB NFIC

1.25e-0312832PF03165
DomainDynein_heavy_chain_D4_dom

DNAH7 DYNC1H1

1.72e-0314832IPR024317
DomainDynein_HC_stalk

DNAH7 DYNC1H1

1.72e-0314832IPR024743
DomainDynein_heavy_dom-2

DNAH7 DYNC1H1

1.72e-0314832IPR013602
DomainDHC_N2

DNAH7 DYNC1H1

1.72e-0314832PF08393
DomainMT

DNAH7 DYNC1H1

1.72e-0314832PF12777
DomainAAA_8

DNAH7 DYNC1H1

1.72e-0314832PF12780
DomainDHC_fam

DNAH7 DYNC1H1

1.97e-0315832IPR026983
DomainDynein_heavy_dom

DNAH7 DYNC1H1

1.97e-0315832IPR004273
DomainDynein_heavy

DNAH7 DYNC1H1

1.97e-0315832PF03028
DomainAMP-bd_C

ACSM2A ACSM2B

2.54e-0317832IPR025110
DomainAMP-binding_C

ACSM2A ACSM2B

2.54e-0317832PF13193
DomainCH

DST SPTBN1 SYNE2

3.03e-0365833SM00033
DomainCH

DST SPTBN1 SYNE2

3.74e-0370833PF00307
Domain-

DST SPTBN1 SYNE2

3.89e-03718331.10.418.10
DomainCH

DST SPTBN1 SYNE2

4.21e-0373833PS50021
DomainCH-domain

DST SPTBN1 SYNE2

4.54e-0375833IPR001715
DomainAMP-binding_CS

ACSM2A ACSM2B

5.92e-0326832IPR020845
PathwayREACTOME_RHOU_GTPASE_CYCLE

PTK2B DST SPTAN1 SPTBN1

1.91e-0539584MM15607
PathwayREACTOME_RHOU_GTPASE_CYCLE

PTK2B DST SPTAN1 SPTBN1

2.11e-0540584M41816
PathwayREACTOME_UTILIZATION_OF_KETONE_BODIES

ACAT1 BDH1

9.93e-054582MM15459
PathwayWP_DISORDERS_IN_KETOLYSIS

ACAT1 BDH1

1.65e-045582M48310
PathwayWP_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES

ACAT1 BDH1

1.65e-045582MM15883
PathwayWP_DISORDERS_IN_KETONE_BODY_SYNTHESIS

ACAT1 BDH1

1.65e-045582M45560
PathwayBIOCARTA_LDL_PATHWAY

ACAT1 LPL

2.47e-046582M22051
PathwayREACTOME_CONJUGATION_OF_SALICYLATE_WITH_GLYCINE

ACSM2A ACSM2B

2.47e-046582MM14693
PathwayREACTOME_AMINO_ACID_CONJUGATION

ACSM2A ACSM2B

3.45e-047582MM14598
PathwayKEGG_BUTANOATE_METABOLISM

ACAT1 ACSM2A BDH1

3.61e-0434583M3397
PathwayREACTOME_SYNTHESIS_OF_KETONE_BODIES

ACAT1 BDH1

4.58e-048582M27718
PathwayWP_KETOGENESIS_AND_KETOLYSIS

ACAT1 BDH1

4.58e-048582M39836
PathwayREACTOME_SYNTHESIS_OF_KETONE_BODIES

ACAT1 BDH1

4.58e-048582MM15460
PathwayREACTOME_RHOV_GTPASE_CYCLE

DST SPTAN1 SPTBN1

4.65e-0437583M41819
PathwayREACTOME_RHOV_GTPASE_CYCLE

DST SPTAN1 SPTBN1

4.65e-0437583MM15610
PathwayREACTOME_AMINO_ACID_CONJUGATION

ACSM2A ACSM2B

5.88e-049582M26968
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SPTAN1 SPTBN1

7.33e-0410582MM15112
PathwayREACTOME_KETONE_BODY_METABOLISM

ACAT1 BDH1

7.33e-0410582MM15437
PathwayKEGG_MEDICUS_REFERENCE_AUTOPHAGY_VESICLE_NUCLEATION_ELONGATION_MATURATION_PI3P_SYNTHESIS_BY_PI3KC3_C1

WDR45B ATG14

7.33e-0410582M47974
PathwayREACTOME_KETONE_BODY_METABOLISM

ACAT1 BDH1

7.33e-0410582M27706
PathwayWP_APOPTOSISRELATED_NETWORK_DUE_TO_ALTERED_NOTCH3_IN_OVARIAN_CANCER

CUL5 PTK2B AXIN1

1.34e-0353583M39688
PathwayWP_8P231_COPY_NUMBER_VARIATION_SYNDROME

MTMR8 ERI1 AXIN1

1.41e-0354583M48073
PathwayPID_TGFBR_PATHWAY

SPTBN1 SMURF2 AXIN1

1.41e-0354583M286
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

DST ACAT1 SPTAN1 SPTBN1 SYNE2 USP24 PUM3 SERPINH1 DYNC1H1 RRP1

4.49e-06653851022586326
Pubmed

The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population.

ACSM2A ACSM2B

5.90e-06285216521160
Pubmed

Identification of a mouse brain beta-spectrin cDNA and distribution of its mRNA in adult tissues.

SPTAN1 SPTBN1

5.90e-0628521742606
Pubmed

Transcriptional diversity during lineage commitment of human blood progenitors.

NFIB NFIC

5.90e-06285225258084
Pubmed

Comparative analyses of disease risk genes belonging to the acyl-CoA synthetase medium-chain (ACSM) family in human liver and cell lines.

ACSM2A ACSM2B

5.90e-06285219634011
Pubmed

Cbl-b accelerates trypsin-induced cell detachment through ubiquitination and degradation of proline-rich tyrosine kinase 2.

PTK2B CBLB

5.90e-06285225099615
Pubmed

Analyses of the genetic diversity and protein expression variation of the acyl: CoA medium-chain ligases, ACSM2A and ACSM2B.

ACSM2A ACSM2B

5.90e-06285229948332
Pubmed

Immune chromatin reader SP140 regulates microbiota and risk for inflammatory bowel disease.

SP140L SP140

5.90e-06285236130593
Pubmed

Spectrin-actin interaction is required for neurite extension in NB 2a/dl neuroblastoma cells.

SPTAN1 SPTBN1

5.90e-0628528776664
Pubmed

Cloning of a portion of the chromosomal gene and cDNA for human beta-fodrin, the nonerythroid form of beta-spectrin.

SPTAN1 SPTBN1

5.90e-0628528406479
Pubmed

Epigenetic reader SP140 loss of function drives Crohn's disease due to uncontrolled macrophage topoisomerases.

SP140L SP140

5.90e-06285235952671
Pubmed

The role of Sp140 revealed in IgE and mast cell responses in Collaborative Cross mice.

SP140L SP140

5.90e-06285234156030
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

PTK2B DST USP22 SPTAN1 SPTBN1 SYNE2 RALGAPB LARP1B RAB21 SERPINH1 DNAH7

8.09e-06861851136931259
Pubmed

HENA, heterogeneous network-based data set for Alzheimer's disease.

PTK2B DST SPTAN1 SPTBN1 DYNC1H1

1.18e-0512085531413325
Pubmed

Functional proteomics mapping of a human signaling pathway.

CUL5 DST SPTBN1 MCAM HBP1 QARS1 CBLB SMURF2 DYNC1H1

1.45e-0559185915231748
Pubmed

The complete amino acid sequence for brain beta spectrin (beta fodrin): relationship to globin sequences.

SPTAN1 SPTBN1

1.77e-0538528479293
Pubmed

Nuclear factor I transcription factors regulate IGF binding protein 5 gene transcription in human osteoblasts.

NFIB NFIC

1.77e-05385218809517
Pubmed

Interaction of the C-terminal domain of delta glutamate receptor with spectrin in the dendritic spines of cultured Purkinje cells.

SPTAN1 SPTBN1

1.77e-05385210576550
Pubmed

NFI-B3, a novel transcriptional repressor of the nuclear factor I family, is generated by alternative RNA processing.

NFIB NFIC

1.77e-0538529099724
Pubmed

Developmental expression of brain beta-spectrin isoform messenger RNAs.

SPTAN1 SPTBN1

1.77e-0538521467942
Pubmed

alpha -Catenin binds directly to spectrin and facilitates spectrin-membrane assembly in vivo.

SPTAN1 SPTBN1

1.77e-05385211069925
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

ASXL1 DST SACS SPTAN1 SPTBN1 PARP9 DYNC1H1

1.77e-0533285737433992
Pubmed

AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.

ACAT1 SPTAN1 SPTBN1 GADL1 RAB21 SERPINH1 DYNC1H1 AXIN1

2.50e-0548485831995728
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

PLEKHH1 ACAD11 ACACB NFIB SYNE2 USP24 ATG14 RAB21 DNAH7

2.65e-0563885931182584
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

SLX9 GNL3L ACAD11 SPTAN1 SPTBN1 PUM3 ZCCHC17 LARP1B QARS1 RAB21 BDH1 DYNC1H1 RRP1

2.77e-051371851336244648
Pubmed

Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons.

SP140L SP140

3.53e-05485234151776
Pubmed

Nuclear factor one transcription factors as epigenetic regulators in cancer.

NFIB NFIC

3.53e-05485228076901
Pubmed

The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation.

SPTAN1 SPTBN1

3.53e-05485221566095
Pubmed

Remarkable homology among the internal repeats of erythroid and nonerythroid spectrin.

SPTAN1 SPTBN1

3.53e-0548523862089
Pubmed

Transcription factor NF 1 expression in involuting mammary gland.

NFIB NFIC

3.53e-05485210959417
Pubmed

Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH.

NFIB NFIC

3.53e-0548527590749
Pubmed

The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal.

KIF20A SYNE2

3.53e-05485233686165
Pubmed

RFX1 and NF-1 associate with P sequences of the human growth hormone locus in pituitary chromatin.

NFIB NFIC

3.53e-05485212624117
Pubmed

Phosphorylation of a threonine unique to the short C-terminal isoform of betaII-spectrin links regulation of alpha-beta spectrin interaction to neuritogenesis.

SPTAN1 SPTBN1

3.53e-05485217088250
Pubmed

Expression of Acsm2, a kidney-specific gene, parallels the function and maturation of proximal tubular cells.

ACSM2A ACSM2B

3.53e-05485232830538
Pubmed

Brain beta spectrin isoform 235 (Spnb-2) maps to mouse chromosome 11.

SPTAN1 SPTBN1

3.53e-0548521638088
Pubmed

Altered expression of the developmentally regulated NFI gene family during phorbol ester-induced differentiation of human leukemic cells.

NFIB NFIC

3.53e-0548529052991
Pubmed

Expression patterns of the four nuclear factor I genes during mouse embryogenesis indicate a potential role in development.

NFIB NFIC

3.53e-0548529056636
Pubmed

Spectrin alpha II and beta II isoforms interact with high affinity at the tetramerization site.

SPTAN1 SPTBN1

3.53e-05485212820899
Pubmed

Outside-in signaling pathway linked to CD146 engagement in human endothelial cells.

PTK2B MCAM

3.53e-05485211036077
Pubmed

Genomic organization, splice products and mouse chromosomal localization of genes for transcription factor Nuclear Factor One.

NFIB NFIC

3.53e-05485212568726
Pubmed

Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.

KIAA0408 DST SPTAN1 SPTBN1 DYNC1H1

3.58e-0515185517043677
Pubmed

Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy.

ACAT1 BDH1

5.87e-05585221791085
Pubmed

The protein stability of Axin, a negative regulator of Wnt signaling, is regulated by Smad ubiquitination regulatory factor 2 (Smurf2).

SMURF2 AXIN1

5.87e-05585220858899
Pubmed

A distal axonal cytoskeleton forms an intra-axonal boundary that controls axon initial segment assembly.

SPTAN1 SPTBN1

5.87e-05585222632975
Pubmed

MicroRNA-27a/b regulates cellular cholesterol efflux, influx and esterification/hydrolysis in THP-1 macrophages.

ACAT1 LPL

5.87e-05585224608080
Pubmed

The prototypical 4.1R-10-kDa domain and the 4.1g-10-kDa paralog mediate fodrin-actin complex formation.

SPTAN1 SPTBN1

5.87e-05585211274145
Pubmed

IFT80 negatively regulates osteoclast differentiation via association with Cbl-b to disrupt TRAF6 stabilization and activation.

IFT80 CBLB

5.87e-05585235733270
Pubmed

Regulation of the CYP3A4 and CYP3A7 promoters by members of the nuclear factor I transcription factor family.

NFIB NFIC

5.87e-05585219706729
Pubmed

Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo.

ACAT1 BDH1 DYNC1H1

7.29e-053385326025364
Pubmed

Identification of transcriptionally regulated mRNAs from mouse Schwann cell precursors using modified RNA fingerprinting methods.

SPTAN1 SPTBN1

8.80e-0568529211987
Pubmed

ST3GAL1 and βII-spectrin pathways control CAR T cell migration to target tumors.

SPTAN1 SPTBN1

8.80e-05685237069398
Pubmed

CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia.

ASXL1 CBLB

8.80e-05685221346257
Pubmed

Temporal control of a dendritogenesis-linked gene via REST-dependent regulation of nuclear factor I occupancy.

NFIB NFIC

8.80e-05685221270437
Pubmed

Faciogenital Dysplasia 5 supports cancer stem cell traits in basal-like breast cancer by enhancing EGFR stability.

DST ACAT1 SPTAN1 SMURF2 DYNC1H1

1.09e-0419185533762435
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

KIF20A SLX9 GNL3L DST ACAT1 SPTAN1 SPTBN1 PUM3 ERI1 QARS1 SERPINH1 DYNC1H1

1.09e-041353851229467282
Pubmed

Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

ASXL1 SLC9A8 SYNE2 DNAH7

1.18e-0410285410231032
Pubmed

Host cell targets of tegument protein VP22 of herpes simplex virus 1.

PTK2B SMURF2

1.23e-04785221424732
Pubmed

ATM-mediated phosphorylation activates the tumor-suppressive function of B56γ-PP2A.

CCNG1 PPP2R5C

1.23e-04785221460856
Pubmed

GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin.

PPP2R5C AXIN1

1.23e-04785210698523
Pubmed

NFI in the development of the olfactory neuroepithelium and the regulation of olfactory marker protein gene expression.

NFIB NFIC

1.23e-04785210762365
Pubmed

TGF-β/NF1/Smad4-mediated suppression of ANT2 contributes to oxidative stress in cellular senescence.

NFIB NFIC

1.23e-04785225220407
Pubmed

Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest.

CCNG1 PPP2R5C

1.64e-04885211956189
Pubmed

A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55.

CCNG1 PPP2R5C

1.64e-04885217245430
Pubmed

Human transcription factor protein interaction networks.

ASXL1 DST USP22 ACACB NFIB NFIC SPTAN1 SPTBN1 SYNE2 PUM3 QARS1 DYNC1H1

1.82e-041429851235140242
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

DST SACS ACAT1 SYNE2 PUM3 QARS1 RAB21 SERPINH1 DYNC1H1 RRP1

1.99e-041024851024711643
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SLC9A8 ATP8B4 TTBK1 SACS PUM3 ATG14 RAB21

2.10e-0449385715368895
Pubmed

Formin 2 Regulates Lysosomal Degradation of Wnt-Associated β-Catenin in Neural Progenitors.

SMURF2 AXIN1

2.10e-04985229659741
Pubmed

High-resolution map and imprinting analysis of the Gtl2-Dnchc1 domain on mouse chromosome 12.

PPP2R5C DYNC1H1

2.10e-04985216309881
Pubmed

Disruption of axo-glial junctions causes cytoskeletal disorganization and degeneration of Purkinje neuron axons.

SPTAN1 SPTBN1

2.10e-04985216551741
Pubmed

Early cellular mechanisms of type I interferon-driven susceptibility to tuberculosis.

SP140L SP140

2.10e-04985238029747
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

ASXL1 SLC9A8 DST SYNE2 RALGAPB

2.33e-0422585512168954
Pubmed

MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.

ACAT1 NFIB SYNE2 PUM3 QARS1 DYNC1H1

2.52e-0435885632460013
Pubmed

Cell organization, growth, and neural and cardiac development require αII-spectrin.

SPTAN1 SPTBN1

2.62e-041085222159418
Pubmed

USP9X-mediated NRP1 deubiquitination promotes liver fibrosis by activating hepatic stellate cells.

SPTAN1 SPTBN1

2.62e-041085236653359
Pubmed

Generation and analysis of 280,000 human expressed sequence tags.

CUL5 CACNA1F SLX9 DST LARP1B BDH1

2.92e-043688568889549
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

PLEKHH1 FAIM DST SACS MTIF2 SPTAN1 SPTBN1 DNAI7 QARS1 SMURF2 DYNC1H1

2.93e-041285851135914814
Pubmed

The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.

CUL5 ACAD11 RAB21 SERPINH1 DYNC1H1

2.97e-0423785529564676
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

DST ACAT1 NFIC SPTAN1 LPL SYNE2 USP24 QARS1 RAB21 SERPINH1 DYNC1H1

3.17e-041297851133545068
Pubmed

Brain proteins interacting with the tetramerization region of non-erythroid alpha spectrin.

SPTAN1 SPTBN1

3.20e-041185217607528
Pubmed

Nfix regulates fetal-specific transcription in developing skeletal muscle.

NFIB NFIC

3.20e-041185220178747
Pubmed

OTUD4-mediated GSDME deubiquitination enhances radiosensitivity in nasopharyngeal carcinoma by inducing pyroptosis.

SPTAN1 SPTBN1

3.20e-041185236411454
Pubmed

The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway.

DST AXIN1

3.20e-041185216815997
Pubmed

Analysis of the DNA sequence and duplication history of human chromosome 15.

GOLGA6L6 ATP8B4 GOLGA6L22

3.56e-045685316572171
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

ACACB ACAT1 USP24 ZCCHC17 ERI1 QARS1 RAB21 SERPINH1 BDH1 DYNC1H1 RRP1

3.63e-041318851130463901
Pubmed

An integrated genetic, radiation hybrid, physical and transcription map of a region of distal mouse chromosome 12, including an imprinted locus and the 'Legs at odd angles' (Loa) mutation.

PPP2R5C DYNC1H1

3.83e-041285211867214
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

PTK2B TTBK1 PPP2R5C GNL3L MTMR8 USP24 ACSM2A SMURF2

4.21e-0473085834857952
Pubmed

alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells.

SPTAN1 SPTBN1

4.52e-041385218796539
Pubmed

Nuclear factor I coordinates multiple phases of cerebellar granule cell development via regulation of cell adhesion molecules.

NFIB NFIC

4.52e-041385217553984
Pubmed

Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression.

USP22 USP24

4.52e-041385235913115
Pubmed

The cell proliferation antigen Ki-67 organises heterochromatin.

CUL5 GNL3L DST NFIC PUM3 JRKL

5.17e-0441085626949251
Pubmed

TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.

SLX9 GNL3L DST SPTAN1 SPTBN1 ZCCHC17 SERPINH1 DYNC1H1 RRP1

5.21e-0494985936574265
Pubmed

Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.

DNAH7 DYNC1H1

5.27e-04148529373155
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

SLX9 ACAD11 PUM3 ATG14 ZCCHC17 ERI1 QARS1 RRP1

5.44e-0475985835915203
Pubmed

Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.

DST ACAT1 NFIB SPTBN1 DYNC1H1

5.46e-0427185525737280
Pubmed

POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1.

FSIP1 SPTBN1 SYNE2 RAB21 PASD1

6.03e-0427785530745168
Pubmed

Trim43a, Trim43b, and Trim43c: Novel mouse genes expressed specifically in mouse preimplantation embryos.

TRIM43B TRIM51

6.07e-041585219703589
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

KIF20A DST ACACB MCAM ZCCHC17 RAB21 DNAH7 DYNC1H1

6.34e-0477785835844135
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

PTK2B SACS SPTAN1 SPTBN1 DYNC1H1

6.43e-0428185528706196
Pubmed

A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.

CUL5 DST SPTAN1 SPTBN1 DYNC1H1

6.75e-0428485529459677
GeneFamilyEF-hand domain containing|Spectrins

SPTAN1 SPTBN1

2.10e-0475821113
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

ASXL1 PPP2R5C DST SACS NFIB MTIF2 SYNE2 USP24 PUM3 RAB21 CBLB SMURF2 CREB5

2.44e-068568213M4500
CoexpressionGSE36888_UNTREATED_VS_IL2_TREATED_STAT5_AB_KNOCKIN_TCELL_2H_DN

CCNG1 SP140L PUM3 IFT80 ADAM28 CREB5 SP140

2.78e-06196827M8757
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_TTD_DN

ASXL1 DST NFIB RALGAPB CREB5

6.74e-0684825M13008
CoexpressionNAKAYA_PBMC_FLUARIX_FLUVIRIN_AGE_18_50YO_CORRELATED_WITH_HAI_28DY_RESPONSE_AT_7DY_NEGATIVE

CSRNP1 ASXL1 PPP2R5C SPTBN1 RALGAPB HBP1 ATG14 IFT80 ADAM28

1.75e-05474829M40991
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

ASXL1 SP140L SPTBN1 SYNE2 CBLB ADAM28 SP140

9.90e-08196857c225c8eb2fe9a10f0cf574c7d8b6206887aac2df
ToppCellLPS_IL1RA-Endothelial-Endothelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

DST NFIB SPTAN1 SPTBN1 SYNE2 SERPINH1 DYNC1H1

1.14e-0720085772ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCellLPS_IL1RA-Endothelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

DST NFIB SPTAN1 SPTBN1 SYNE2 SERPINH1 DYNC1H1

1.14e-072008575c092b2ecc081b5d04476c56333c338cd89ab984
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Gen_Cap|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

DST USP22 NFIB SPTAN1 SPTBN1 SYNE2 SERPINH1

1.14e-07200857a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCelldroplet-Kidney-nan-3m|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DST ACAT1 SPTAN1 LPL SPTBN1 SERPINH1

2.08e-06196856b880c9665d42c76ea1971d4e49d7ecf72fcfafb6
ToppCellCOVID_non-vent-Lymphocytic|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

PPP2R5C TRANK1 SPTAN1 SPTBN1 SYNE2 SP140

2.14e-06197856c672915f8c8c1e948d251f6eaf9f84a5600c1193
ToppCellCOVID-CD4-exh_CD4|COVID / Condition, Cell_class and T cell subcluster

TRANK1 SPTAN1 SPTBN1 SYNE2 CBLB SP140

2.14e-0619785639ee4b93625c994813044d8dd8854fba2bd99940
ToppCellCOVID-19_Moderate|World / disease group, cell group and cell class

TRANK1 SP140L SPTBN1 SYNE2 PARP9 SP140

2.27e-06199856952fac67588ad5676f5939e3c7f8bac803c27064
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-dn_T|COVID-19_Mild / Disease, condition lineage and cell class

TRANK1 SPTAN1 SPTBN1 SYNE2 USP24 CBLB

2.27e-06199856f307d4887b28cf60a591439e278fd668409cb104
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

DST USP22 NFIB SPTAN1 SPTBN1 SYNE2

2.34e-06200856dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellLPS_only-Endothelial|LPS_only / Treatment groups by lineage, cell group, cell type

DST NFIB SPTAN1 SPTBN1 SYNE2 SERPINH1

2.34e-0620085681e76508c9050d533853d5fd2f3097b27613d836
ToppCellControl_saline-Endothelial-Endothelial-Gen_Cap|Control_saline / Treatment groups by lineage, cell group, cell type

DST NFIB SPTAN1 LPL SPTBN1 SERPINH1

2.34e-062008563b97920e1e6e2f09ddba2a861baa9c00c2970f4c
ToppCellLPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

DST SPTAN1 SPTBN1 SYNE2 SERPINH1 DYNC1H1

2.34e-0620085679e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-CD4+_T_activated|COVID-19_Mild / Disease, condition lineage and cell class

TRANK1 DST SPTAN1 SPTBN1 SYNE2 PARP9

2.34e-06200856d9e8a0d047d4403fb7265fde7448e23a7780785c
ToppCellLPS_only-Endothelial-Endothelial|LPS_only / Treatment groups by lineage, cell group, cell type

DST NFIB SPTAN1 SPTBN1 SYNE2 SERPINH1

2.34e-062008564bb609a284d4e6066f17470a1736076aa4a1f84c
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KIF20A ACSM2A DNAH7 CREB5 ACSM2B

1.12e-05153855499670e716fc85ce76630fc813cec86f8419f2a1
ToppCelldroplet-Marrow-BM-1m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCNG1 MGAM PTPDC1 GADL1 USP24

2.14e-05175855c1c722db42da9b8a2a46e516ddb83d9be5e2e504
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_cytotoxic-D|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PTK2B PPP2R5C TRANK1 ACSM2A SP140

2.14e-05175855a3f8c54c77bce9b035a4835945ab341909be4946
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MGAM ATP8B4 SYNE2 ACSM2A ACSM2B

2.20e-051768551595dbeee336a81e581325d63208ec6262664ee9
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

TRANK1 SPTAN1 SPTBN1 SYNE2 PARP9

2.59e-051828551aea96ee211f7b9caef7fd385233f51be6021a73
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TRANK1 SPTAN1 SPTBN1 SYNE2 PARP9

2.59e-05182855b427e43ee523a3ea9eca3207f3d82042f10f022a
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TRANK1 SPTAN1 SPTBN1 SYNE2 PARP9

2.59e-05182855c0f63cfc67d61c0877b7acb2946dfb35aae8a8f5
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TRANK1 SPTAN1 SPTBN1 SYNE2 PARP9

2.59e-051828554cb182ef39be2044a6ad7266f332d4177591e550
ToppCellCOVID-19_Mild-Lymphoid_T/NK-CD4+_T_activated|COVID-19_Mild / Disease group, lineage and cell class

TRANK1 SPTAN1 SPTBN1 SYNE2 PARP9

2.66e-051838557717fce227b4e02ed41baad8ae7dd2e22bd7c13e
ToppCellCalu_3-infected|Calu_3 / Cell line, Condition and Strain

TRANK1 DST SP140L SYNE2 PARP9

2.66e-051838558f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCellCOVID-19-kidney-PCT-S1|kidney / Disease (COVID-19 only), tissue and cell type

NFIB SYNE2 ACSM2A CREB5 ACSM2B

2.73e-0518485551ed1ebfdef45149541917c66cbacad87072e51f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MGAM ATP8B4 SYNE2 ACSM2A ACSM2B

2.73e-051848559434731f651820b05335085582960f08fbf895de
ToppCellT_cells-ISG-high_CD4+_T_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

KIAA0408 TRANK1 SYNE2 PARP9 SP140

3.02e-051888556f8946d4710f6e32c937213f99b790b098b8819c
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NFIB SYNE2 ACSM2A CREB5 ACSM2B

3.10e-0518985528b502611829e4a24caff2562545c7db97686099
ToppCellrenal_cortex_nuclei-Adult_normal_reference|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

MGAM ACACB SYNE2 CBLB ACSM2B

3.10e-05189855a48df46274d51e84ffb40264646de7346104efb9
ToppCellCOVID-19-kidney-PCT-S2|kidney / Disease (COVID-19 only), tissue and cell type

NFIB SYNE2 ACSM2A CREB5 ACSM2B

3.10e-051898550be5c669b6b308bd98ddb70c84877c62a6244bbd
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PTK2B NFIB ACSM2A CREB5 ACSM2B

3.18e-05190855989d4eefd22d66ecb857836f8fdbcf41e3047f84
ToppCellPND10|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DST NFIB SPTAN1 SPTBN1 RRP1

3.18e-05190855d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CUL5 MTIF2 SPTBN1 SYNE2 LARP1B

3.26e-0519185560c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NFIB SYNE2 ACSM2A CREB5 ACSM2B

3.26e-051918553c464645d0e7e423f791bd63bf5bcf11f6b590d3
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NFIB SYNE2 ACSM2A CREB5 ACSM2B

3.26e-051918551c1d13144259b998d4a0e85142f7afef2ef1e63f
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CUL5 MTIF2 SPTBN1 SYNE2 LARP1B

3.26e-0519185509db184cb90fe282a14474d7217068c58092c6f8
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CUL5 MTIF2 SPTBN1 SYNE2 LARP1B

3.26e-05191855973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCellhuman_hepatoblastoma-Tumor_cells-T8|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

DST ACACB ACSM2A BDH1 ACSM2B

3.34e-05192855e785135262f4c9cc66c403bf362bb34643b212c5
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NFIB SYNE2 ACSM2A CREB5 ACSM2B

3.51e-051948557002937e8903e037332a215d00fbc7c7843b33f2
ToppCellIPF-Multiplet-Multiplet|IPF / Disease state, Lineage and Cell class

NFIB SPTBN1 SYNE2 DNAI7 DNAH7

3.60e-05195855fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCellCOVID-19_Moderate-CD8+_T_activated|World / disease group, cell group and cell class

PPP2R5C TRANK1 SYNE2 PARP9 CBLB

3.60e-05195855070c5d3bdbd4ea54a579c01c37fb99bcf823982e
ToppCellIPF-Multiplet|IPF / Disease state, Lineage and Cell class

NFIB SPTBN1 SYNE2 DNAI7 DNAH7

3.60e-05195855eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCellCOVID_non-vent-Lymphocytic-T_cell-CD4+_Memory_T_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

TRANK1 DST SPTAN1 SPTBN1 SYNE2

3.60e-0519585522191d361af136942508f1553ff41a626ed982ad
ToppCelldroplet-Kidney-nan-3m-Epithelial|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DST ACAT1 LPL SPTBN1 ACSM2B

3.69e-051968559f39cb3de886283da34ee7511a92d94930a6c851
ToppCellsaliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ASXL1 SACS USP24 CBLB ADAM28

3.69e-051968550175b097ad1338a07afebe3b5c7fd0bb0bb950f7
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

DST NFIB LPL SPTBN1 CBLB

3.78e-0519785531a1852911bda38543916585fda34255fd62a134
ToppCellfacs-Trachea-3m|Trachea / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CSRNP1 DST NFIB SPTBN1 SERPINH1

3.78e-05197855e77016d64b1cac9825fec7cfe5071f1567401187
ToppCellfacs-Trachea-nan-3m|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSRNP1 DST NFIB SPTBN1 SERPINH1

3.78e-051978550353d925ee4b7aefc2c51b5fab873f465cdf9ebc
ToppCellmild-dn_T|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TRANK1 SPTBN1 SYNE2 USP24 CBLB

3.78e-0519785507a1f59c83b748825e0708cd1cc7b63a2cb856cc
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

DST NFIB LPL SPTBN1 CBLB

3.78e-051978550034bae02ee7fcfea520d453ca3c842ab6963b12
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

DST NFIB LPL SPTBN1 CBLB

3.78e-0519785511a4c417f035e554431a8f03be13b5eefa3530c0
ToppCellCOVID_vent-Lymphocytic|COVID_vent / Disease condition, Lineage, Cell class and subclass

TRANK1 SPTAN1 SPTBN1 SYNE2 SP140

3.87e-05198855ee80f647317377081b4bd194ee2801f556b3a53b
ToppCellASK452-Endothelial-Endothelium|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq

NFIB SPTBN1 SYNE2 MCAM SMURF2

3.87e-05198855e282769f5fa1765bcce79a0ed9d761bf2e14b012
ToppCellControl-Control-Lymphocyte-T/NK-CD4+_T_activated|Control / Disease, condition lineage and cell class

ASXL1 TRANK1 SPTBN1 SYNE2 PARP9

3.87e-05198855ee71543559836fd59adc0da877b2ca538cba60cb
ToppCellSepsis-Leuk-UTI-Lymphocyte-T/NK-gd_T|Leuk-UTI / Disease, condition lineage and cell class

PPP2R5C FSIP1 SYNE2 GOLGA8R CBLB

3.96e-05199855b2c1b9ee764e1246bfa3ecf666ca76ae4ac6c362
ToppCellcontrol-unassigned|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ACAD11 ACACB FSIP1 BDH1 ZNF554

3.96e-0519985550e2da35edff1aadef939cfbd4549f73c1a07717
ToppCellASK452-Endothelial|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq

NFIB SPTBN1 SYNE2 MCAM SMURF2

3.96e-051998550bc97a9a78aaafd1554ae6a61356ed9ea4983fa5
ToppCellcontrol-unassigned|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ACAD11 ACACB FSIP1 BDH1 ZNF554

3.96e-051998555db7c8089172ac8e796613b3cef618d87007a0ab
ToppCellmild-CD8+_Tem|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

PPP2R5C TRANK1 SYNE2 PARP9 CBLB

4.06e-05200855d8aec4904c9420b8f9d7508658ba1e36c66cdfcc
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SPTAN1 SPTBN1 SYNE2 SERPINH1 DYNC1H1

4.06e-0520085589821a264e872ed53e08e9d3609d5cc5c314503e
ToppCellCOVID-19-COVID-19_Severe-Lymphocyte-T/NK-dn_T|COVID-19_Severe / Disease, condition lineage and cell class

PPP2R5C TRANK1 SPTBN1 SYNE2 CBLB

4.06e-05200855d01aa5fccada22f97d8350ad5888df2aadb5bb1c
ToppCellControl_saline-Endothelial-Endothelial|Control_saline / Treatment groups by lineage, cell group, cell type

DST NFIB SPTAN1 SPTBN1 SERPINH1

4.06e-05200855e77eba6172cabf85b8028638ed35299f2f079cd8
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated|COVID-19_Mild / Disease, condition lineage and cell class

TRANK1 SYNE2 USP24 GOLGA8R PARP9

4.06e-052008552281debd86e5d92e8fe0397aec9ef670800f7471
ToppCellLPS_anti-TNF-Endothelial|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

DST NFIB SPTAN1 SPTBN1 SERPINH1

4.06e-052008551d105eeda5a2c51f9a4654ffc79b7e2348ad593b
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NFIB SYNE2 ACSM2A CREB5 ACSM2B

4.06e-05200855105564ee05bd11685b5747ee32d5350cf3c2e2e1
ToppCellLPS_anti-TNF-Endothelial-Endothelial|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

DST NFIB SPTAN1 SPTBN1 SERPINH1

4.06e-0520085560d2cbf41f37f1b11eddb4c9d9246c9c1fc5a5af
ToppCellControl_saline-Endothelial|Control_saline / Treatment groups by lineage, cell group, cell type

DST NFIB SPTAN1 SPTBN1 SERPINH1

4.06e-052008553372c488a39fe812fa94e4f0564594186fea3db5
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Sst_(Striatum,_interneuron)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

WDR87 MEIOSIN ADAM28

1.96e-04598530946b53be12a9926d876c75ddf5dec414a4f8063
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Sst_(Striatum,_interneuron)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

WDR87 MEIOSIN ADAM28

1.96e-04598535da8beaf3c690861d5561ae40d4ff7c2d3732ef4
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Sst_(Striatum,_interneuron)--|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

WDR87 MEIOSIN ADAM28

1.96e-04598531c26fabefafd4ce05f21750ae69895c488ea1a11
ToppCellTCGA-Kidney|World / Sample_Type by Project: Shred V9

MGAM ACAD11 ACSM2A ACSM2B

2.00e-04151854e31974c0d0a0c644205a0ee6013ab74a09d8a306
ToppCellPBMC-Control-cDC_1|Control / Compartment, Disease Groups and Clusters

PLEKHH1 TRANK1 SP140L PARP9

2.26e-041568549b6c5bcac516a62bcc1f5be32ffa8c92735ef0bc
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

PTK2B PPP2R5C SYNE2 CBLB

2.32e-04157854170197b76620df31495f1247f365da382b2d8045
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

PTK2B PPP2R5C SYNE2 CBLB

2.32e-04157854c21520301cc0d5d4b1cc4b8ec735f9adb698e768
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

PTK2B PPP2R5C SYNE2 CBLB

2.38e-041588547274f020c0ecf216da4b6689c62bc5f49c29b6f3
ToppCellTCGA-Mesothelium-Primary_Tumor-Mesothelioma-Epitheliod-2|TCGA-Mesothelium / Sample_Type by Project: Shred V9

TRANK1 ACACB PARP9 THAP6

2.49e-04160854d288b0a315f6adc0be4bdc89fa67bf93679a743f
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c02-NCAM1|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ATP8B4 SPTBN1 CBLB SPDYE4

2.61e-041628549b1c07f0af657095379380c39d763cab0ad73e74
ToppCellCOVID-19-kidney-PEC|COVID-19 / Disease (COVID-19 only), tissue and cell type

TRIM43B SYNE2 ACSM2A DNAH7

3.00e-04168854a086c306be430adf0632ba53e98cd8014d2de330
ToppCellTCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-8|TCGA-Liver / Sample_Type by Project: Shred V9

ACAT1 ACSM2A BDH1 ACSM2B

3.21e-04171854c4a919fe3d56ae6df2fcab6686abacc10befc053
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD4_INF-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TRANK1 SYNE2 MTMR8 SP140

3.21e-04171854e6dfbd2652b67577c8834c05348f62150637f348
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD4_INF|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TRANK1 SYNE2 MTMR8 SP140

3.21e-04171854ddaeb96ce9c9c3bf232b4a42266fa2ee7e8f3f41
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MGAM ATP8B4 ACSM2A ACSM2B

3.35e-041738548888434641ea554a9b62c436e87920378eef29cd
ToppCellfacs-Pancreas-Exocrine-24m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRIM43B ACACB ACSM2B OSGIN1

3.50e-041758547329ebb135fc4311ee9595729b62a5d152c9de8c
ToppCell5'-Adult-Appendix-Hematopoietic-T_cells-CX3CR1+_CD8_Tmem|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PPP2R5C SYNE2 GADL1 CBLB

3.58e-041768546b06da40eb97ea2db09f3a769494738b3e5fe3fa
ToppCellCOVID-19-kidney-Distal_Epi_Doublet_(PCT)|kidney / Disease (COVID-19 only), tissue and cell type

ACSM2A SERPINH1 CREB5 ACSM2B

3.58e-0417685436f77d878a53b30465b0dea8333a3865dba75613
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ATP8B4 SYNE2 ACSM2A ACSM2B

3.66e-041778542f81b26be89cc2fd8eafadaf7eae3c6ad6521462
ToppCellIIF-Lymphocyte-T_NK-MAIT|IIF / Disease, Lineage and Cell Type

CSRNP1 PPP2R5C SYNE2 MCAM

3.74e-04178854be777ebef8f09a1a16fcee8fc69a65ab295b6e1d
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Rectal_Adenocarcinoma-7|TCGA-Colorectal / Sample_Type by Project: Shred V9

ASXL1 SLC9A8 RALGAPB JRKL

3.74e-04178854edc76b8f15056ec1c9a1c61a048b6331a92592d6
ToppCellCOVID-19-Endothelial_cells-Endothelial_cells_(other)|COVID-19 / group, cell type (main and fine annotations)

NFIB SPTBN1 SYNE2 MCAM

3.98e-0418185426eb4ee57a70dbf54e096b73129fda9dfda1f6ec
ToppCellCOVID-19-kidney-PCT-S1|COVID-19 / Disease (COVID-19 only), tissue and cell type

SYNE2 ACSM2A DNAH7 ACSM2B

4.15e-041838546878d14026c3df6aa12e45dfad94b32fa9d9b0b7
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_2|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

SLC9A8 GNL3L MTIF2 ERI1

4.15e-04183854310ad42b2b5d8ddd01d3a12db338f80ac1f5d08e
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

SLC9A8 GNL3L MTIF2 ERI1

4.15e-04183854fef51dcf180e6d4e136362c7e140ec5ef372e6d0
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIAA0408 CACNA1F MGAM TRANK1

4.23e-041848542cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIAA0408 CACNA1F MGAM TRANK1

4.23e-04184854ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIAA0408 CACNA1F MGAM TRANK1

4.23e-041848542b19a8c5f823e00812908b23e66bb4e563278aff
ToppCelldroplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l20-1|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MGAM SPTBN1 CREB5 ACSM2B

4.32e-04185854d5f5866924648a3c14e2596218fd548a31777aa3
ToppCellCOVID-19_Moderate-NK_activated|World / disease group, cell group and cell class

MGAM TRANK1 SYNE2 PARP9

4.41e-04186854ff8f32f69516bf785224fa12f8139a95359b0279
ToppCelldroplet-Kidney-nan-21m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DST ACACB LPL SYNE2

4.41e-041868548eafd4bea692f7ef33de27dd53f9d1fe67deaad8
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NFIB ACSM2A CREB5 ACSM2B

4.41e-04186854f28d72b47624b69a580b4429e2be560a26898591
DrugAC1NUTWC

MGAM ACSM2A ACSM2B

1.86e-074833CID005460914
DiseaseX-21319 measurement

ACSM2A ACSM2B

7.44e-062812EFO_0800807
DiseaseX-11478 measurement

ACSM2A ACSM2B

2.23e-053812EFO_0021242
Disease3-hydroxyhexanoate measurement

ACSM2A ACSM2B

7.40e-055812EFO_0800378
Diseaseindoleacetoylcarnitine measurement

ACSM2A ACSM2B

1.11e-046812EFO_0800106
Diseasevolumetric bone mineral density

PTK2B SPTBN1 AXIN1

2.12e-0442813EFO_0007620
DiseaseLiver Cirrhosis, Experimental

PLEKHH1 CCNG1 ACAT1 SPTAN1 LPL SERPINH1 BDH1 OSGIN1 SP140

2.71e-04774819C0023893
Diseasesalicylate measurement

ATP8B4 ACSM2A

4.03e-0411812EFO_0021161
Diseasecolorectal cancer, inflammatory bowel disease

ATP8B4 SP140

1.23e-0319812EFO_0003767, MONDO_0005575
Diseasealkaline phosphatase measurement

PPP2R5C TRANK1 ACACB LPL SPTBN1 ERI1 LARP1B AXIN1 OSGIN1

1.85e-031015819EFO_0004533
Diseaseurinary uromodulin measurement

ACSM2A DYNC1H1 ACSM2B

2.37e-0396813EFO_0005663
Diseaseupper face morphology measurement

SP140L CREB5 SP140

2.44e-0397813EFO_0010949

Protein segments in the cluster

PeptideGeneStartEntry
VLKKVIDWMKLKELG

ERI1

206

Q8IV48
FLPQKKMIKEQIEWL

CUL5

746

Q93034
LVGMEIWTDKDKIKI

ADAM28

251

Q9UKQ2
IAKKMWEELPEVVRK

BDH1

256

Q02338
EFQKEVLKAMEGKWI

ATG14

91

Q6ZNE5
GKIQRAKLRDKEWKM

ACSM2A

556

Q08AH3
ETKEEKRWKEMKLQV

COX10

136

Q12887
LKMKEREEAWVKIEN

PPP2R5C

421

Q13362
KWMNVKVGDIIKLEN

ATP8B4

126

Q8TF62
RIRQEMEKEKKVEQW

ASXL1

336

Q8IXJ9
IDKLKEMAKVEGLWN

ACAD11

421

Q709F0
KNWVKELRKMLGNEI

RAB21

111

Q9UL25
KVWRLDLVMVILFKG

NFIB

126

O00712
LVLKWLIEQDKKMKE

PUM3

556

Q15397
KVQEEMARKKERGLW

PARP9

606

Q8IXQ6
RMLEKGVISDILEWK

ACACB

2306

O00763
RMEKIVLEKVCWKVK

CCNG1

136

P51959
KIWKRMKQKLLDEVI

CACNA1F

1556

O60840
RKVWVMSLEKKAEEL

CREB5

396

Q02930
VWIKEVITKAGMKLK

MTIF2

136

P46199
RTFKGLMILIEKEWI

MTMR8

361

Q96EF0
RQRLKEEKLEMLQWK

CSRNP1

141

Q96S65
NDIEKEWGKLIIAML

DST

356

Q03001
EWGKLIIAMLEREKA

DST

361

Q03001
RWRKQKVEMELPGDK

MGAM

796

O43451
VEKTWKLMDKVVRLC

CBLB

46

Q13191
EVDIGELLMLKLKWK

LPL

396

P06858
WKIMQKKIEELCREV

KIAA0408

36

Q6ZU52
MWKQEEKIREQEEKI

GOLGA6L6

581

A8MZA4
KIREQEEIWRQKEKM

GOLGA6L22

406

H0YM25
MWKQEEKIREQEEKI

GOLGA6L22

556

H0YM25
ISRAWKKILPMVEEK

JRKL

381

Q9Y4A0
KEELKRKVEMWQKEL

PTPDC1

606

A2A3K4
LRMEEKWLLKGKLRN

MEIOSIN

46

C9JSJ3
LMKKLKEQLEERTWL

PASD1

376

Q8IV76
GLQIDWEKIKAKIEM

IFT80

741

Q9P2H3
WEKIKAKIEMEITKE

IFT80

746

Q9P2H3
DPLKKEMEEVWKIVR

C16orf96

871

A6NNT2
KIMQWIIEGEKEISR

AXIN1

631

O15169
KQMREWEGKLLLLQE

DNAH7

961

Q8WXX0
GKEEIRKEWMFKLVG

FAIM

36

Q9NVQ4
KGWMIVEILKEGLQK

DNAI7

401

Q6TDU7
KQGLEMRIKLWEEIK

FSIP1

141

Q8NA03
DIVKRKREENLKMVW

DYNC1H1

436

Q14204
VILGDRWKKMKNEER

HBP1

466

O60381
EEAVLKKMIEFIGWK

GADL1

156

Q6ZQY3
LWEAEKVKMRQILDK

PTK2B

796

Q14289
LKKEKQDMRWVEQLE

GOLGA8R

266

I6L899
KIMVLGANWKEVLLK

SEC14L2

216

O76054
IKLVQLGMAKDDILW

SACS

2146

Q9NZJ4
IVDEKMRKKIEPEKW

LARP1B

281

Q659C4
DLEVKDWMQKKRRGL

OSGIN1

151

Q9UJX0
KERKVWVKENMVLNL

MCAM

436

P43121
VLKWADGKMIKNEVD

QARS1

156

P47897
AELQMKRIWGEKEKK

SYNE2

2686

Q8WXH0
QLVLQEWKKERKEMR

NT5DC3

451

Q86UY8
EAELKKKWVEEMREK

GNL3L

56

Q9NVN8
LEKLLTKEQLKIWMG

SERPINH1

281

P50454
IIEFKKLANWKEEEM

SLC9A8

106

Q9Y2E8
KVLKMQGWEERQIEE

RRP1

131

P56182
VLKDVGLKKEDIAMW

ACAT1

336

P24752
KVMIWDDLKKKTVIE

WDR45B

81

Q5MNZ6
DENIKRKWVLAMKRL

THAP6

31

Q8TBB0
KVWRLDLVMVILFKG

NFIC

126

P08651
QGLKEPMWLDKIKKR

SP140L

506

Q9H930
RQRWLVELGKLEEKM

SLFNL1

366

Q499Z3
NKEWLDKIEKEGMQL

SPTBN1

1326

Q01082
GKIQRTKLRDKEWKM

ACSM2B

556

Q68CK6
KDLWKRLMIKFRGEE

SMURF2

416

Q9HAU4
IIAKEEQRKAWKMQG

USP22

126

Q9UPT9
QLPWRKIKDKEQVGM

TTBK1

236

Q5TCY1
KVWVKLIGREMKNDR

ZCCHC17

66

Q9NP64
VKEMVKDVLKGQNWL

KIF20A

141

O95235
WLDSKQIRQEEMKKL

KIF20A

211

O95235
LIWQKVDEVMTKEIK

THG1L

241

Q9NWX6
WVVETLCGLKMKLKR

SPDYE4

81

A6NLX3
RREELLKKMQSLWEK

TRIM51

136

Q9BSJ1
WELLLEKMREKGIKL

SPTAN1

131

Q13813
VLPKKEKMKLRREQW

SLX9

101

Q9NSI2
EKMKLRREQWLQKIE

SLX9

106

Q9NSI2
LLKTDKEVKWTMEVI

RALGAPB

56

Q86X10
IKEWVTLKLAKLEME

PLEKHH1

131

Q9ULM0
EKLELIGMDFIWKIA

USP24

816

Q9UPU5
KEPMWLDKIKKRLNE

SP140

796

Q13342
DREKLLKQMRILWKK

TRIM43B

136

A6NCK2
WLMKTETRLKKEGIV

TRANK1

2881

O15050
WGKVPRKDLIVMLKD

POTEH

186

Q6S545
IEKKMKLAQKRERWI

WDR87

1806

Q6ZQQ6
MIKLIREDGGWKQLE

ZNF554

176

Q86TJ5
RVMEELLKWGEELGK

NLRP13

611

Q86W25