Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phosphatidylinositol phosphate binding	RAB35 ARHGAP32 KCNH1 EXOC1 GOLPH3	1.51e-04	199	51	5	GO:1901981
GeneOntologyMolecularFunction	structural constituent of skin epidermis	KRT72 KRT71 KRT74	1.80e-04	43	51	3	GO:0030280
Domain	Keratin_2_head	KRT72 KRT71 KRT74	3.73e-05	24	51	3	IPR032444
Domain	Keratin_2_head	KRT72 KRT71 KRT74	3.73e-05	24	51	3	PF16208
Domain	Keratin_II	KRT72 KRT71 KRT74	4.77e-05	26	51	3	IPR003054
Domain	Intermediate_filament_CS	KRT72 KRT71 KRT74	6.79e-04	63	51	3	IPR018039
Domain	Filament	KRT72 KRT71 KRT74	9.62e-04	71	51	3	SM01391
Domain	IF	KRT72 KRT71 KRT74	1.00e-03	72	51	3	PS00226
Domain	Filament	KRT72 KRT71 KRT74	1.04e-03	73	51	3	PF00038
Domain	IF	KRT72 KRT71 KRT74	1.17e-03	76	51	3	IPR001664
Domain	P-loop_NTPase	RAB35 ATAD3B ARL5B VWA8 UCKL1 CARD10 ATP5F1A MYO5C	1.96e-03	848	51	8	IPR027417
Domain	Ig_E-set	UNC119B MYCBP2 KCNJ10	2.88e-03	104	51	3	IPR014756
Domain	-	RAB35 ATAD3B ARL5B VWA8 UCKL1 CARD10 ATP5F1A	3.95e-03	746	51	7	3.40.50.300
Domain	RhoGAP	ARHGAP32 INPP5B	1.25e-02	62	51	2	SM00324
Domain	RhoGAP	ARHGAP32 INPP5B	1.28e-02	63	51	2	PF00620
Domain	RHOGAP	ARHGAP32 INPP5B	1.32e-02	64	51	2	PS50238
Domain	RhoGAP_dom	ARHGAP32 INPP5B	1.32e-02	64	51	2	IPR000198
Domain	-	ARHGAP32 INPP5B	1.32e-02	64	51	2	1.10.555.10
Pubmed	K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath-specific type II epithelial keratins of the human hair follicle.	KRT72 KRT71 KRT74	1.26e-08	4	52	3	12648212
Pubmed	Keratin K6irs is specific to the inner root sheath of hair follicles in mice and humans.	KRT72 KRT71	2.19e-06	2	52	2	11703281
Pubmed	OTUD7B stabilizes estrogen receptor α and promotes breast cancer cell proliferation.	ESR1 OTUD7B	2.19e-06	2	52	2	34035221
Pubmed	No association between the KCNH1, KCNJ10 and KCNN3 genes and schizophrenia in the Han Chinese population.	KCNH1 KCNJ10	6.57e-06	3	52	2	20933057
Pubmed	Non-nuclear estrogen receptor alpha activation in endothelium reduces cardiac ischemia-reperfusion injury in mice.	A1CF ESR1	6.57e-06	3	52	2	28457941
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	ATAD3B MYCBP2 VWA8 EIF3A OTUD7B	1.31e-05	202	52	5	24639526
Pubmed	Autosomal-dominant woolly hair resulting from disruption of keratin 74 (KRT74), a potential determinant of human hair texture.	KRT71 KRT74	1.31e-05	4	52	2	20346438
Pubmed	Hippo signalling maintains ER expression and ER+ breast cancer growth.	STK4 ESR1	1.31e-05	4	52	2	33658690
Pubmed	p38γ and p38δ regulate postnatal cardiac metabolism through glycogen synthase 1.	A1CF MAPK13	1.31e-05	4	52	2	34758018
Pubmed	Novel protein kinase C isoforms regulate human keratinocyte differentiation by activating a p38 delta mitogen-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha.	PRKCH MAPK13	2.19e-05	5	52	2	12080077
Pubmed	The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes.	ATAD3B VWA8 FECH IDH3B CRAT ATP5F1A	2.24e-05	382	52	6	29222160
Pubmed	Estrogen receptor α promotes protein synthesis by fine-tuning the expression of the eukaryotic translation initiation factor 3 subunit f (eIF3f).	ESR1 EIF3A	3.28e-05	6	52	2	30573685
Pubmed	The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.	KRT72 RAB35 ATAD3B KRT71 KRT74 EIF3A HEATR5B ATP5F1A TUBAL3	4.78e-05	1153	52	9	29845934
Pubmed	RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers.	KRT72 KRT71 KRT74	8.71e-05	57	52	3	31862882
Pubmed	New consensus nomenclature for mammalian keratins.	KRT72 KRT71 KRT74	1.17e-04	63	52	3	16831889
Pubmed	SDS3 interacts with ARNT in an AhR ligand-specific manner regulating expression of cKrox and S100A4 in CD4+CD8+ DPK thymocytes differentiation.	RAB35 MAPK4	1.20e-04	11	52	2	22981438
Pubmed	The interactome of the prostate-specific protein Anoctamin 7.	FECH MYO5C OTUD7B	1.29e-04	65	52	3	32176628
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	RAB35 GAS2L3 MYCBP2 EIF3A IDH3B HEATR5B ATP5F1A MYO5C	1.31e-04	1024	52	8	24711643
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	RMND5A MYCBP2 FECH MLLT3 EXOC1 GOLPH3	1.41e-04	533	52	6	25544563
Pubmed	Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.	ATAD3B VWA8 FECH IDH3B CRAT ATP5F1A	1.54e-04	542	52	6	14651853
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	VWA8 FECH EXOC1 IDH3B CLUH ATP5F1A	1.84e-04	560	52	6	35241646
Pubmed	gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes.	MAPK4 MAPK13	1.97e-04	14	52	2	12239168
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	ATAD3B RMND5A VWA8 CARD10 EXOC1 GOLPH3 EIF3A IDH3B ATP5F1A	2.57e-04	1440	52	9	30833792
Pubmed	The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate.	KRT72 KRT71	2.60e-04	16	52	2	22144916
Pubmed	Comprehensive analysis of keratin gene clusters in humans and rodents.	KRT72 KRT74	2.60e-04	16	52	2	15085952
Pubmed	Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.	ATAD3B VWA8 FECH GOLPH3 IDH3B CRAT CLUH ATP5F1A	2.65e-04	1136	52	8	34800366
Pubmed	Allele Frequencies of 25 Polymorphisms Pertaining to Cancer Risk for Japanese, Koreans and Chinese.	CYP2E1 ESR1	3.69e-04	19	52	2	12718576
Pubmed	A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice.	STK4 A1CF	3.69e-04	19	52	2	25787764
Pubmed	mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells.	FAM184B ATAD3B VWA8	4.34e-04	98	52	3	34943047
Pubmed	Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.	STK4 MLLT3 EIF3A CCNJ ATP5F1A	4.65e-04	432	52	5	23455922
Pubmed	Variability in Streptavidin-Sepharose Matrix Quality Can Significantly Affect Proximity-Dependent Biotinylation (BioID) Data.	VWA8 FECH IDH3B CLUH ATP5F1A	4.95e-04	438	52	5	32628020
Pubmed	Rare independent mutations in renal salt handling genes contribute to blood pressure variation.	SLC12A4 KCNJ10	4.97e-04	22	52	2	18391953
Pubmed	Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen.	KRT72 ESR1	6.43e-04	25	52	2	17388661
Pubmed	CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs.	CLUH ATP5F1A	6.43e-04	25	52	2	28188211
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	STK4 UNC119B RMND5A MYCBP2 FECH EXOC1 GOLPH3 CLUH	7.22e-04	1321	52	8	27173435
Pubmed	Cardiac Med1 deletion promotes early lethality, cardiac remodeling, and transcriptional reprogramming.	A1CF ATP5F1A	8.08e-04	28	52	2	28159809
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ZNF462 ARHGAP32 ATAD3B EIF3A PUS7	8.42e-04	493	52	5	15368895
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	STK4 ATAD3B RMND5A MYCBP2 VWA8 EIF3A	8.87e-04	754	52	6	33060197
Pubmed	CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer.	ATAD3B EIF3A ATP5F1A TUBAL3	9.12e-04	288	52	4	31501420
Pubmed	iRhom2 mutation leads to aberrant hair follicle differentiation in mice.	KRT72 KRT71	9.29e-04	30	52	2	25546423
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	ARHGAP32 VWA8 CLUH	9.86e-04	130	52	3	12421765
Pubmed	Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.	ATAD3B VWA8 INPP5B FECH CLUH	1.02e-03	515	52	5	31617661
Pubmed	Biological insights from 108 schizophrenia-associated genetic loci.	SLC12A4 ZSWIM6 PUS7 OTUD7B	1.10e-03	303	52	4	25056061
Pubmed	GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.	ARL5B ESR1	1.12e-03	33	52	2	21658281
Pubmed	Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart.	A1CF ATP5F1A	1.12e-03	33	52	2	22904094
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	STK4 KRT72 ARHGAP32 ATAD3B EXOC1 EIF3A IDH3B ATP5F1A	1.21e-03	1431	52	8	37142655
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	KRT72 FAM184B ATAD3B SLC12A4 KRT71 KRT74 EIF3A ATP5F1A	1.27e-03	1442	52	8	35575683
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	ATAD3B RMND5A MYCBP2 EXOC1 EIF3A ATP5F1A	1.27e-03	809	52	6	32129710
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	SLC12A4 PRKCH EXOC1 EIF3A	1.38e-03	322	52	4	26514267
Pubmed	Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome.	FECH CRAT ATP5F1A	1.40e-03	147	52	3	26465331
Pubmed	Allele frequencies of single nucleotide polymorphisms (SNPs) in 40 candidate genes for gene-environment studies on cancer: data from population-based Japanese random samples.	CYP2E1 ESR1	1.49e-03	38	52	2	14634838
Interaction	CLEC11A interactions	STK4 ARHGAP32 ATAD3B MYCBP2 VWA8	4.81e-06	96	52	5	int:CLEC11A
Cytoband	12q13.13	KRT72 KRT71 KRT74	6.24e-05	67	52	3	12q13.13
GeneFamily	Keratins, type II	KRT72 KRT71 KRT74	1.57e-05	27	33	3	609
GeneFamily	Mitogen-activated protein kinases	MAPK4 MAPK13	2.49e-04	13	33	2	651
Disease	Woolly hair, congenital	KRT71 KRT74	2.80e-05	5	50	2	C0345427
Disease	Hypotrichosis	KRT71 KRT74	4.20e-05	6	50	2	C0020678
Disease	Wooly hair	KRT71 KRT74	5.88e-05	7	50	2	C0343073
Disease	vascular endothelial growth factor measurement	ZNF462 VWA8 PRKCH	1.19e-04	56	50	3	EFO_0004762
Disease	acetone measurement	CYP2E1 VWA8	4.72e-04	19	50	2	EFO_0010989
Disease	Drug habituation	FAM184B PRKCH MYO5C	9.89e-04	115	50	3	C0013170
Disease	Substance-Related Disorders	FAM184B PRKCH MYO5C	9.89e-04	115	50	3	C0236969
Disease	Drug abuse	FAM184B PRKCH MYO5C	9.89e-04	115	50	3	C0013146
Disease	Drug Use Disorders	FAM184B PRKCH MYO5C	9.89e-04	115	50	3	C0013222
Disease	Drug Dependence	FAM184B PRKCH MYO5C	9.89e-04	115	50	3	C1510472
Disease	Substance Dependence	FAM184B PRKCH MYO5C	9.89e-04	115	50	3	C0038580
Disease	Substance Use Disorders	FAM184B PRKCH MYO5C	9.89e-04	115	50	3	C0038586
Disease	Organic Mental Disorders, Substance-Induced	FAM184B PRKCH MYO5C	9.89e-04	115	50	3	C0029231
Disease	Prescription Drug Abuse	FAM184B PRKCH MYO5C	9.89e-04	115	50	3	C4316881
Disease	Substance abuse problem	FAM184B PRKCH MYO5C	1.01e-03	116	50	3	C0740858

Protein segments in the cluster

Peptide	Gene	Start	Entry
NLRYLMKFLARLAEE	BARGIN	406	Q6ZT62
YLQEMEDLRLKHRTL	CARD10	356	Q9BWT7
LYRMLAHEDLRKAAV	ARL5B	106	Q96KC2
YESHRAAAMARRKLL	A1CF	186	Q9NQ94
KAYLDELVELHRRLM	MLLT3	501	P42568
RHLAVYLLDLFMDRY	CCNJ	61	Q5T5M9
ARLAHYLEKALLDMR	CRAT	601	P43155
AYLMRHRGLSLAKAF	DUSP28	116	Q4G0W2
VFYLHSRLLERAAKM	ATP5F1A	341	P25705
MARDYDHLFKLLIIG	RAB35	1	Q15286
FHLIRMLLDEYILLA	RFX6	521	Q8HWS3
RKHFDYNDEKFLRLM	CYP2E1	186	P05181
FHDRDLMLRKALYAL	OTUD7B	206	Q6GQQ9
RKMAELVHFLLLKYR	MAGEA12	111	P43365
MEHIADKRFLYLKDL	KCNJ10	41	P78508
VLRHYDLDLVRAAMA	NAAA	51	Q02083
LAEEHAKLFMYQLLR	MAPK4	121	P31152
MLELKADYERRLQHL	FAM184B	151	Q9ULE4
LHSLSKMLEDLRRVY	CCDC178	386	Q5BJE1
YLRLLFFIHDRRKMR	GPR27	201	Q9NS67
LYDLLLEMLDAHRLH	ESR1	536	P03372
RYHEMLNSVRDFLKL	KCNH1	511	O95259
AKRAYRELLLLKHMQ	MAPK13	66	O15264
TLEFLMRHLSLLADY	ARHGAP32	496	A7KAX9
ASYDMRLRRKLDLFA	IDH3B	126	O43837
HLKASAAMVRLRLYD	HEATR5B	661	Q9P2D3
LHRLYHLSREMRKNL	EIF3A	296	Q14152
RYRLGDKILFIRMLH	GAS2L3	241	Q86XJ1
RMDRRLLALIYLAHA	GOLPH3	231	Q9H4A6
FHYLMAFLRELLKNS	INPP5B	931	P32019
FHRDLLRYAKLMEWL	EXOC1	381	Q9NV70
HDFLLRLFLDRDLMT	FECH	86	P22830
EFKLHRLYFISLLMG	RMND5A	191	Q9H871
RMLLRDVKALTLHYD	SARAF	36	Q96BY9
KDIHLARRLYDMAAQ	SEL1L2	606	Q5TEA6
LDIDNMRHKIRDYSL	PUS7	556	Q96PZ0
VRRKALMRLEYEGLH	MYCBP2	4501	O75592
ARLDHKFDLMYAKRA	TUBAL3	396	A6NHL2
MKKDLAVFLYHLRLE	SLC12A4	891	Q9UP95
LLLFMDEADAFLRKR	ATAD3B	406	Q5T9A4
AFVEHRYLLFMKLAA	CLUH	611	O75153
RMIERHYFREHLLKN	UNC119B	171	A6NIH7
DAELAYKIALRAMRL	ZSWIM6	781	Q9HCJ5
RDLRFRLKHLLRMYA	ZCCHC18	186	P0CG32
IFYSKRLMRLLIEHA	UCKL1	351	Q9NWZ5
RSHLALAMFTREDKY	ZNF462	2011	Q96JM2
GLEYLHFMRKIHRDI	STK4	136	Q13043
LMSAERYDKLLRDHT	VWA8	206	A3KMH1
LHQAKEELARMLREY	KRT71	401	Q3SY84
LHQAKEELARMLREY	KRT72	396	Q14CN4
LHQAKEELARMLREY	KRT74	411	Q7RTS7
ALMFLHDKGIIYRDL	PRKCH	466	P24723
YDMLVEILRASKFHL	MYO5C	571	Q9NQX4