Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessauditory receptor cell stereocilium organization

SCRIB STRC STRCP1

2.28e-0526443GO:0060088
GeneOntologyBiologicalProcessauditory receptor cell morphogenesis

SCRIB STRC STRCP1

3.90e-0531443GO:0002093
GeneOntologyBiologicalProcessauditory receptor cell development

SCRIB STRC STRCP1

8.47e-0540443GO:0060117
GeneOntologyBiologicalProcessregulation of acetylcholine secretion, neurotransmission

CACNA1A ADORA2A

9.28e-057442GO:0014056
GeneOntologyBiologicalProcessacetylcholine secretion, neurotransmission

CACNA1A ADORA2A

9.28e-057442GO:0014055
GeneOntologyBiologicalProcessacetylcholine secretion

CACNA1A ADORA2A

1.24e-048442GO:0061526
GeneOntologyBiologicalProcessembryo development

GATA6 NCOR2 SCRIB TDRD6 STRC KDM6B SLC39A1 ZBED3 SPECC1 AHDC1 STRCP1

1.63e-0414374411GO:0009790
GeneOntologyBiologicalProcesscentral nervous system development

CACNA1A ADORA2A NCOR2 POU3F1 TAOK1 SCRIB CLCN2 KDM6B PLXDC1 COQ8B

1.69e-0411974410GO:0007417
GeneOntologyBiologicalProcessinner ear receptor cell stereocilium organization

SCRIB STRC STRCP1

1.97e-0453443GO:0060122
GeneOntologyBiologicalProcessacetylcholine transport

CACNA1A ADORA2A

2.90e-0412442GO:0015870
GeneOntologyBiologicalProcessmetencephalon development

CACNA1A NCOR2 SCRIB COQ8B

3.14e-04153444GO:0022037
GeneOntologyBiologicalProcessepidermal cell differentiation

GATA6 POU3F1 SCRIB STRC STRCP1

3.34e-04284445GO:0009913
GeneOntologyBiologicalProcessacetate ester transport

CACNA1A ADORA2A

3.42e-0413442GO:1901374
GeneOntologyBiologicalProcessinner ear auditory receptor cell differentiation

SCRIB STRC STRCP1

3.94e-0467443GO:0042491
GeneOntologyBiologicalProcessepidermis development

GATA6 NCOR2 POU3F1 SCRIB STRC STRCP1

4.15e-04461446GO:0008544
GeneOntologyBiologicalProcessepithelial cell differentiation

GATA6 NCOR2 POU3F1 SCRIB STRC CLCN2 KDM6B STRCP1

4.46e-04870448GO:0030855
GeneOntologyBiologicalProcesspons development

CACNA1A SCRIB

4.59e-0415442GO:0021548
GeneOntologyBiologicalProcessinner ear receptor cell development

SCRIB STRC STRCP1

5.08e-0473443GO:0060119
GeneOntologyBiologicalProcessregulation of synaptic transmission, cholinergic

CACNA1A ADORA2A

5.93e-0417442GO:0032222
GeneOntologyBiologicalProcesshair cell differentiation

SCRIB STRC STRCP1

6.16e-0478443GO:0035315
GeneOntologyBiologicalProcessembryonic morphogenesis

GATA6 SCRIB STRC KDM6B SLC39A1 AHDC1 STRCP1

7.20e-04713447GO:0048598
GeneOntologyCellularComponentkinocilium

STRC STRCP1

3.88e-0414442GO:0060091
GeneOntologyCellularComponent9+2 non-motile cilium

STRC STRCP1

3.88e-0414442GO:0097732
DomainTSP_1

ADAMTS8 THSD7B ADAMTS14

4.10e-0463433PF00090
DomainTSP1

ADAMTS8 THSD7B ADAMTS14

4.49e-0465433SM00209
DomainTSP1_rpt

ADAMTS8 THSD7B ADAMTS14

4.49e-0465433IPR000884
DomainTSP1

ADAMTS8 THSD7B ADAMTS14

4.49e-0465433PS50092
DomainADAM_spacer1

ADAMTS8 ADAMTS14

1.27e-0323432IPR010294
DomainADAM_spacer1

ADAMTS8 ADAMTS14

1.27e-0323432PF05986
DomainPeptidase_M12B_ADAM-TS

ADAMTS8 ADAMTS14

1.38e-0324432IPR013273
DomainADAM_Cys-rich

ADAMTS8 ADAMTS14

1.75e-0327432IPR006586
DomainACR

ADAMTS8 ADAMTS14

1.75e-0327432SM00608
DomainPeptidase_M12B_N

ADAMTS8 ADAMTS14

3.63e-0339432IPR002870
DomainPep_M12B_propep

ADAMTS8 ADAMTS14

3.63e-0339432PF01562
DomainDISINTEGRIN_1

ADAMTS8 ADAMTS14

3.82e-0340432PS00427
DomainADAM_MEPRO

ADAMTS8 ADAMTS14

3.82e-0340432PS50215
DomainDISINTEGRIN_2

ADAMTS8 ADAMTS14

3.82e-0340432PS50214
DomainReprolysin

ADAMTS8 ADAMTS14

3.82e-0340432PF01421
DomainPeptidase_M12B

ADAMTS8 ADAMTS14

3.82e-0340432IPR001590
DomainDisintegrin_dom

ADAMTS8 ADAMTS14

4.01e-0341432IPR001762
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

MUC21 ADAMTS8 THSD7B ADAMTS14

1.23e-0568304M27303
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS8 THSD7B ADAMTS14

7.55e-0539303M27417
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS8 THSD7B ADAMTS14

7.55e-0539303MM15165
PathwayREACTOME_O_LINKED_GLYCOSYLATION

MUC21 ADAMTS8 THSD7B ADAMTS14

7.94e-05109304MM15164
PathwayREACTOME_O_LINKED_GLYCOSYLATION

MUC21 ADAMTS8 THSD7B ADAMTS14

8.52e-05111304M27416
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

MUC21 ADAMTS8 THSD7B ADAMTS14

2.27e-04143304M27275
PathwayREACTOME_SURFACTANT_METABOLISM

GATA6 ADORA2A

1.08e-0323302MM15279
Pubmed

Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.

STRC STRCP1

1.56e-06244234910522
Pubmed

Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.

STRC STRCP1

1.56e-06244211687802
Pubmed

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

ADORA2A NCOR2 SCRIB DNAJC14 PLXDC1 SLC39A1 UST GRAMD1A

2.34e-0669744828298427
Pubmed

Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.

STRC STRCP1

4.69e-06344230801007
Pubmed

SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron.

NCOR2 POU3F1 KDM6B

6.75e-062944317928865
Pubmed

Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.

STRC STRCP1

9.37e-06444218849963
Pubmed

An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.

STRC STRCP1

1.56e-05544224920589
Pubmed

Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane.

STRC STRCP1

4.36e-05844221165971
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

NCOR2 DISP2 WIZ KDM6B DNAJC14 ZNRF3 ZBED3 AHDC1

6.49e-05110544835748872
Pubmed

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

CACNA1A TAOK1 LMTK3 BSN SPECC1

7.58e-0534744517114649
Pubmed

Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.

STRC STRCP1

8.54e-051144231776257
Pubmed

Clarin-2 is essential for hearing by maintaining stereocilia integrity and function.

STRC STRCP1

8.54e-051144231448880
Pubmed

Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast.

GATA6 POU3F1

1.02e-041244227292645
Pubmed

Inhibition of RIF1 by SCAI Allows BRCA1-Mediated Repair.

BSN AHDC1

1.02e-041244228700933
Pubmed

RNA Pol II pausing facilitates phased pluripotency transitions by buffering transcription.

GATA6 POU3F1

1.02e-041244235981753
Pubmed

Multiple roles of integrin-α3 at the neuromuscular junction.

CACNA1A BSN

1.02e-041244228386022
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

ADAMTS8 THSD7B ADAMTS14

1.20e-047544320637190
Pubmed

Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

GATA6 ADORA2A NCOR2 ADAMTS14 SPECC1 CRIP3 ALKBH2 AHDC1

1.25e-04121544815146197
Pubmed

Calcium channels link the muscle-derived synapse organizer laminin β2 to Bassoon and CAST/Erc2 to organize presynaptic active zones.

CACNA1A BSN

1.41e-041444221228161
Pubmed

Whole genome RNAi screens reveal a critical role of REV3 in coping with replication stress.

CACNA1A LMTK3

1.86e-041644225113059
Pubmed

Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1.

STRC STRCP1

2.10e-041744220856818
Pubmed

ASPP2 maintains the integrity of mechanically stressed pseudostratified epithelia during morphogenesis.

GATA6 SCRIB

2.64e-041944235177595
Pubmed

Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs.

ADAMTS8 CLCN2 GRAMD1A

2.80e-0410044326073538
Pubmed

Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning.

GATA6 POU3F1

2.93e-042044229412136
Pubmed

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PRUNE2 KDM6B ZNF646

3.15e-041044439205841
Pubmed

Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis.

NCOR2 KDM6B

3.24e-042144230254164
Pubmed

Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants.

NCOR2 TAOK1 COQ8B

4.44e-0411744312107410
Pubmed

Ion channel expression in the developing enteric nervous system.

CACNA1A CLCN2

1.01e-033744225798587
Pubmed

Thyroid hormone receptor repression is linked to type I pneumocyte-associated respiratory distress syndrome.

GATA6 NCOR2

1.01e-033744222001906
Pubmed

A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis.

STRC STRCP1

1.07e-033844238346162
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

TAOK1 ADAMTS8 SCRIB WIZ KDM6B DNAJC14 SPECC1

1.07e-03128544735914814
Cytoband15q15.3

STRC STRCP1

2.66e-042544215q15.3
CytobandEnsembl 112 genes in cytogenetic band chr15q15

DISP2 STRC STRCP1

3.87e-04147443chr15q15
GeneFamilyADAM metallopeptidases with thrombospondin type 1 motif

ADAMTS8 ADAMTS14

6.10e-041935250
ToppCellInfluenza-Influenza_Severe-Lymphocyte-T/NK-NK_CD56bright|Influenza_Severe / Disease, condition lineage and cell class

CAPN12 PCED1A CACNA1A ANKRD23 ALKBH2

1.52e-06199445784e7e7ede2baa28ede600834813e6de2240bfdf
ToppCellfacs-MAT-Fat-3m-Lymphocytic-NK_cell|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADORA2A ADAMTS14 LMTK3 ZNRF3

1.61e-05154444391d40ef902773ffe832a50a14d35d31c56d3723
ToppCellfacs-MAT-Fat-18m-Lymphocytic-NK_cell|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADORA2A ADAMTS14 LMTK3 ZNRF3

1.74e-05157444e6846ffd1bb18bf0469bc6d49ab6cf3533d9cde6
ToppCellInfluenza_Severe-NK_CD56bright|World / Disease group and Cell class

CAPN12 CACNA1A ANKRD23 ALKBH2

1.92e-05161444de802ff96b52d28550a7854fc915f813c76ea271
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-Late_airway_SMC|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

PRUNE2 ADAMTS8 THSD7B UST

2.01e-051634441e8730d75cccf7292010683ab4e81a69d8e3bfa9
ToppCellInfluenza_Severe-NK_CD56bright|Influenza_Severe / Disease group and Cell class

CAPN12 CACNA1A ANKRD23 ALKBH2

2.01e-051634447748d5709e8cf6673f5a8370108309f76cd830f4
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Tall_Cell|TCGA-Thryoid / Sample_Type by Project: Shred V9

CD1A MUC21 ADAMTS14 SPECC1

2.54e-051734442e9dc137f3675eee07f941eb4cfcaf24a83ab0fb
ToppCellfacs-Heart-RV-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADORA2A POU3F1 ANKRD23 AHDC1

2.78e-051774447c3d46ebd7e8726be6871aa9763e281fc0ec6ac8
ToppCellfacs-Heart-RV-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADORA2A POU3F1 ANKRD23 AHDC1

2.78e-05177444e7b1f3092e6b8d0d580f82648035f5ad12be6961
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-enteroendocrine_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A PRUNE2 ADORA2A DISP2

2.84e-0517844430ca37f70d267cc9b40ca3e211f16d30360c3e6b
ToppCellBAL-Severe-Myeloid-cDC-cDC-cDC_3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CD1A DISP2 CRIP3 UST

3.23e-051844441c56378b3888c46258d446b47de4d6282fe74b0d
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-interneuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A PRUNE2 BIRC7 BSN

3.44e-051874441b2fdbfb1ce3f19795dfc4b1da5a94f4b057ec41
ToppCellfacs-Skin-Skin_Anagen-18m-Epithelial-basal_cell_of_epidermis|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POU3F1 KDM6B ZNRF3 SLC39A1

3.67e-051904443639eb9b887a2d76949cad4a2586524fe0e1015f
ToppCellHippocampus-Neuronal|Hippocampus / BrainAtlas - Mouse McCarroll V32

DISP2 TAOK1 LMTK3 BSN

3.98e-051944448aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCellMild-CD8+_T|World / Disease group and Cell class

CAPN12 ADORA2A TAOK1 PLXDC1

3.98e-05194444d64c2efb482bcdef9240977eae1023c4191286e7
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Pericyte-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GATA6 THSD7B CCM2L PLXDC1

4.22e-051974442872a78b1be61aa1d50bc9a49294a21e922dc033
ToppCellTracheal-10x5prime-Stromal-Schwann-Schwann_Myelinating|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1A BIRC7 ANKRD23 CLCN2

4.39e-051994442b567b6fd8addf059bbf2b72c55a7647aefdc595
ToppCellBrain_organoid-organoid_Tanaka_cellReport-3m-Neuronal-Intermediate|3m / Sample Type, Dataset, Time_group, and Cell type.

POU3F1 DISP2 KDM6B PPP1R3E

4.48e-05200444cbd0b9188a94778ffa539912aeb2a4378f0ab88f
Diseaseautosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)

STRC STRCP1

1.70e-062392DOID:0110471 (implicated_via_orthology)
Diseaseosteoarthritis (is_implicated_in)

NCOR2 ADAMTS14

6.30e-0428392DOID:8398 (is_implicated_in)
Diseasereticulocyte measurement

ADGRD2 WIZ BSN KDM6B SPECC1 GRAMD1A

2.42e-031053396EFO_0010700
Diseaseupper aerodigestive tract neoplasm

PRUNE2 MUC21 ZNRF3

4.19e-03246393EFO_0004284
Diseaseendometriosis

CACNA1A BSN SPECC1

4.48e-03252393EFO_0001065

Protein segments in the cluster

PeptideGeneStartEntry
PRGPRHSAPTGPGWH

nan

16

Q6ZR03
PGNGGHSAGPSWRHI

ALKBH2

46

Q6NS38
GGARWPASGPHVSEG

CACNA1A

2386

O00555
GQHPGHWGFPALTEP

ERI3

41

O43414
GFGHGVPDPGAWPSD

ANKRD23

21

Q86SG2
HPPGVWANGSAPHPE

ADORA2A

341

P29274
GSLPWADGTPCGPGH

ADAMTS8

491

Q9UP79
KPWNPAIRAGGHGPD

SPECC1

6

Q5M775
HRGPQPSHWAAGDGP

BIRC7

11

Q96CA5
DKGGGWAPHHGHPGG

AHDC1

771

Q5TGY3
WAPHHGHPGGQAGRN

AHDC1

776

Q5TGY3
GGGSWERRHPGPNPL

CCM2L

276

Q9NUG4
PCAHLPWDAGTGDPG

DISP2

1126

A7MBM2
WRAHGDGPQHPDPDP

GRAMD1A

561

Q96CP6
HPGGTLWPGRVGRHS

ADAMTS14

91

Q8WXS8
LPAGSGPLAGPHHAW

NCOR2

2481

Q9Y618
NPAHWLDPSHGPPGG

DNAJC14

66

Q6Y2X3
WLGLFAPHHGPPRFG

NUDT19

76

A8MXV4
GGNHGAPHRPRWSPN

MUC21

531

Q5SSG8
HGDAWGPERKGSAPP

KDM6B

286

O15054
GWGGHPALGCPHPPE

LMTK3

691

Q96Q04
EGLWPHDEGGPGRHA

BSN

3626

Q9UPA5
AWLSHGPSPGPGHLQ

CD1A

206

P06126
GPNPHGQHWGPVVHR

PCED1A

391

Q9H1Q7
GAGHPVGLAHPQWLP

POU3F1

61

Q03052
GPANHAGGAGAHPGW

GATA6

211

Q92908
SPEVLGPSPEGGGWH

CAPN12

341

Q6ZSI9
GPSPEGGGWHVHTFQ

CAPN12

346

Q6ZSI9
ALGPGPHRWGPCGGS

COQ8B

26

Q96D53
FGPKGGQPHPRHWDG

CRIP3

181

Q6Q6R5
PAGCGAGSGEPPQHW

TDRD6

136

O60522
PHPDPWKGHGDGQSE

PRUNE2

1311

Q8WUY3
PEHPGSGGAPEPQGW

PPP1R3E

261

Q9H7J1
SHNPTGGPGPHWGHP

TAOK1

911

Q7L7X3
HWGHPMGGPPQAWGH

TAOK1

921

Q7L7X3
GISGTPDGRGPWEHP

WIZ

66

O95785
PGALHGELHPSEGPW

WIZ

1191

O95785
GEGPVAPGGWHNGPH

SCRIB

636

Q14160
SWPAAGLGPGHARHV

STRC

896

Q7RTU9
HPGPGMRLYHATGWG

ADGRD2

756

Q7Z7M1
WGPHSRHGLPREGSP

CLCN2

876

P51788
PGRPGHPSGHWATCR

ZBED3

56

Q96IU2
QHPGGGADPWPHGAP

UST

6

Q9Y2C2
PQHWHDGPGVPQASG

SLC39A1

156

Q9NY26
SHPGPEDGADGWGPS

ZNF646

176

O15015
VHSHGAGRGEPWPGP

ZNRF3

636

Q9ULT6
SWPAAGLGPGHARHV

STRCP1

896

A6NGW2
PQPGAGHDEGPGSGW

PLXDC1

21

Q8IUK5
DPHWHVTGPVCGGGI

THSD7B

421

Q9C0I4