Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	hexosyltransferase activity	POMT2 UGT2B4 UGT2B10 B4GALNT2 UGT3A2 MGAT5	9.70e-06	211	47	6	GO:0016758
GeneOntologyMolecularFunction	UDP-glycosyltransferase activity	UGT2B4 UGT2B10 B4GALNT2 UGT3A2 MGAT5	2.93e-05	153	47	5	GO:0008194
GeneOntologyMolecularFunction	aliphatic amine oxidase activity	AOC2 AOC3	3.24e-05	4	47	2	GO:0052595
GeneOntologyMolecularFunction	glycosyltransferase activity	POMT2 UGT2B4 UGT2B10 B4GALNT2 UGT3A2 MGAT5	5.58e-05	288	47	6	GO:0016757
GeneOntologyMolecularFunction	glucuronosyltransferase activity	UGT2B4 UGT2B10 UGT3A2	7.59e-05	35	47	3	GO:0015020
GeneOntologyMolecularFunction	primary methylamine oxidase activity	AOC2 AOC3	1.93e-04	9	47	2	GO:0008131
GeneOntologyMolecularFunction	protein phosphatase inhibitor activity	PPP1R8 PPME1 MGAT5	2.22e-04	50	47	3	GO:0004864
GeneOntologyMolecularFunction	phosphatase inhibitor activity	PPP1R8 PPME1 MGAT5	2.79e-04	54	47	3	GO:0019212
GeneOntologyMolecularFunction	oxidoreductase activity	BLVRB HMGCR ALKBH6 PTGS1 KMO SDHA AOC2 AOC3	3.77e-04	766	47	8	GO:0016491
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	AOC2 AOC3	6.37e-04	16	47	2	GO:0016641
GeneOntologyMolecularFunction	quinone binding	AOC2 AOC3	7.21e-04	17	47	2	GO:0048038
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-NH2 group of donors	AOC2 AOC3	1.00e-03	20	47	2	GO:0016638
GeneOntologyMolecularFunction	protein phosphatase regulator activity	PPP1R8 PPME1 MGAT5	1.68e-03	100	47	3	GO:0019888
GeneOntologyMolecularFunction	phosphatase regulator activity	PPP1R8 PPME1 MGAT5	2.39e-03	113	47	3	GO:0019208
GeneOntologyMolecularFunction	protein phosphatase 2A binding	PPME1 HMGCR	4.40e-03	42	47	2	GO:0051721
GeneOntologyBiologicalProcess	protein N-linked glycosylation via asparagine	UBE2J1 B4GALNT2 MGAT5	2.31e-05	24	48	3	GO:0018279
Domain	-	AOC2 AOC3	1.86e-05	3	47	2	2.70.98.20
Domain	Cu_amine_oxidase_N3	AOC2 AOC3	1.86e-05	3	47	2	IPR015802
Domain	Cu_amine_oxidase_N2	AOC2 AOC3	1.86e-05	3	47	2	IPR015800
Domain	Cu_amine_oxidN2	AOC2 AOC3	1.86e-05	3	47	2	PF02727
Domain	Cu_amine_oxidN3	AOC2 AOC3	1.86e-05	3	47	2	PF02728
Domain	Cu_amine_oxidase_N-reg	AOC2 AOC3	1.86e-05	3	47	2	IPR016182
Domain	Cu_amine_oxid	AOC2 AOC3	1.86e-05	3	47	2	PF01179
Domain	Cu_amine_oxidase_C	AOC2 AOC3	1.86e-05	3	47	2	IPR015798
Domain	COPPER_AMINE_OXID_1	AOC2 AOC3	1.86e-05	3	47	2	PS01164
Domain	COPPER_AMINE_OXID_2	AOC2 AOC3	1.86e-05	3	47	2	PS01165
Domain	UDPGT	UGT2B4 UGT2B10 UGT3A2	1.92e-05	21	47	3	PF00201
Domain	UDPGT	UGT2B4 UGT2B10 UGT3A2	1.92e-05	21	47	3	PS00375
Domain	UDP_glucos_trans	UGT2B4 UGT2B10 UGT3A2	1.92e-05	21	47	3	IPR002213
Domain	Cu_amine_oxidase	AOC2 AOC3	3.71e-05	4	47	2	IPR000269
Domain	EGF-like_CS	LAMA5 FAT2 TENM3 PTGS1 CNTNAP1 EPHA8	4.67e-05	261	47	6	IPR013032
Domain	EGF_2	LAMA5 FAT2 TENM3 PTGS1 CNTNAP1 EPHA8	5.08e-05	265	47	6	PS01186
Domain	LAM_G_DOMAIN	LAMA5 FAT2 CNTNAP1	1.18e-04	38	47	3	PS50025
Domain	Laminin_G_2	LAMA5 FAT2 CNTNAP1	1.38e-04	40	47	3	PF02210
Domain	LamG	LAMA5 FAT2 CNTNAP1	1.84e-04	44	47	3	SM00282
Domain	EGF	LAMA5 FAT2 TENM3 PTGS1 CNTNAP1	3.01e-04	235	47	5	SM00181
Domain	EGF-like_dom	LAMA5 FAT2 TENM3 PTGS1 CNTNAP1	3.93e-04	249	47	5	IPR000742
Domain	WWE	HUWE1 DTX4	4.03e-04	12	47	2	PS50918
Domain	WWE	HUWE1 DTX4	4.03e-04	12	47	2	PF02825
Domain	WWE-dom	HUWE1 DTX4	4.03e-04	12	47	2	IPR004170
Domain	Laminin_G	LAMA5 FAT2 CNTNAP1	4.18e-04	58	47	3	IPR001791
Domain	EGF_1	LAMA5 FAT2 TENM3 PTGS1 CNTNAP1	4.38e-04	255	47	5	PS00022
Domain	Galactose-bd-like	LAMA5 CNTNAP1 EPHA8	1.71e-03	94	47	3	IPR008979
Domain	-	LAMA5 FAT2 CNTNAP1	1.76e-03	95	47	3	2.60.120.200
Domain	TGFb_propeptide	BMP4 GDF6	2.25e-03	28	47	2	PF00688
Domain	TGF-b_N	BMP4 GDF6	2.25e-03	28	47	2	IPR001111
Domain	Abhydrolase_1	PPME1 ABHD13	2.75e-03	31	47	2	PF00561
Domain	EGF_3	FAT2 TENM3 PTGS1 CNTNAP1	2.85e-03	235	47	4	PS50026
Domain	TGF-beta-rel	BMP4 GDF6	2.93e-03	32	47	2	IPR015615
Domain	TGFb_CS	BMP4 GDF6	2.93e-03	32	47	2	IPR017948
Domain	AB_hydrolase_1	PPME1 ABHD13	3.11e-03	33	47	2	IPR000073
Domain	TGFB	BMP4 GDF6	3.90e-03	37	47	2	SM00204
Domain	TGF-b_C	BMP4 GDF6	3.90e-03	37	47	2	IPR001839
Domain	TGF_BETA_2	BMP4 GDF6	3.90e-03	37	47	2	PS51362
Domain	TGF_beta	BMP4 GDF6	3.90e-03	37	47	2	PF00019
Domain	TGF_BETA_1	BMP4 GDF6	3.90e-03	37	47	2	PS00250
Domain	EGF	FAT2 PTGS1 CNTNAP1	3.92e-03	126	47	3	PF00008
Pathway	REACTOME_BIOLOGICAL_OXIDATIONS	UGT2B4 UGT2B10 UGT3A2 PTGS1 AOC2 AOC3	2.39e-05	219	38	6	MM14838
Pathway	REACTOME_BIOLOGICAL_OXIDATIONS	UGT2B4 UGT2B10 UGT3A2 PTGS1 AOC2 AOC3	2.45e-05	220	38	6	M10320
Pathway	REACTOME_GLUCURONIDATION	UGT2B4 UGT2B10 UGT3A2	3.52e-05	24	38	3	MM14599
Pathway	REACTOME_GLUCURONIDATION	UGT2B4 UGT2B10 UGT3A2	3.99e-05	25	38	3	M17787
Pathway	KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	UGT2B4 UGT2B10 BLVRB	1.79e-04	41	38	3	M7399
Pathway	REACTOME_ASPIRIN_ADME	UGT2B4 UGT2B10 UGT3A2	2.22e-04	44	38	3	M45014
Pathway	REACTOME_ASPIRIN_ADME	UGT2B4 UGT2B10 UGT3A2	2.37e-04	45	38	3	MM15694
Pubmed	Mutational screening of 10 genes in Chinese patients with microphthalmia and/or coloboma.	BMP4 OTX2 GDF6	2.94e-07	10	48	3	20057906
Pubmed	The unique substrate specificity of human AOC2, a semicarbazide-sensitive amine oxidase.	AOC2 AOC3	1.87e-06	2	48	2	19588076
Pubmed	Anatomical distribution of primary amine oxidase activity in four adipose depots and plasma of severely obese women with or without a dysmetabolic profile.	AOC2 AOC3	1.87e-06	2	48	2	27766585
Pubmed	Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation: implications on hypertension.	BMP4 PTGS1	5.59e-06	3	48	2	20724703
Pubmed	cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily.	UGT2B4 UGT2B10	5.59e-06	3	48	2	8333863
Pubmed	Characterization of AOC2 gene encoding a copper-binding amine oxidase expressed specifically in retina.	AOC2 AOC3	5.59e-06	3	48	2	14585497
Pubmed	Endoplasmic reticulum-associated ubiquitin-conjugating enzyme Ube2j1 is a novel substrate of MK2 (MAPKAP kinase-2) involved in MK2-mediated TNFα production.	UBE2J1 PTGS1	1.12e-05	4	48	2	24020373
Pubmed	Microphthalmia/Anophthalmia/Coloboma Spectrum – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	BMP4 OTX2 GDF6	1.43e-05	34	48	3	20301552
Pubmed	Functional proteomics mapping of a human signaling pathway.	PPP1R8 LAMA5 BMP4 HUWE1 TENM3 SOX13 RNF111	1.59e-05	591	48	7	15231748
Pubmed	Dmbx1, a novel evolutionarily conserved paired-like homeobox gene expressed in the brain of mouse embryos.	OTX2 LCK	1.86e-05	5	48	2	11744391
Pubmed	Mutational screening of CHX10, GDF6, OTX2, RAX and SOX2 genes in 50 unrelated microphthalmia-anophthalmia-coloboma (MAC) spectrum cases.	OTX2 GDF6	1.86e-05	5	48	2	20494911
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	POMT2 LAMA5 UBE2J1 HMGCR MGAT5 TENM3 TMEM9 PTGS1 CNTNAP1	3.38e-05	1201	48	9	35696571
Pubmed	Neuronal differentiation of precursors in the neocortical ventricular zone is triggered by BMP.	BMP4 GDF6	3.90e-05	7	48	2	9786991
Pubmed	Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria.	PTGS1 SDHA	3.90e-05	7	48	2	29228266
Pubmed	Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs in mouse perinatal development.	UGT2B4 UGT2B10	3.90e-05	7	48	2	26074487
Pubmed	Murine cerberus homologue mCer-1: a candidate anterior patterning molecule.	BMP4 OTX2	3.90e-05	7	48	2	9501024
Pubmed	Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.	TRAPPC10 UBE2J1 HMGCR LCK AOC3	3.93e-05	276	48	5	28319085
Pubmed	Bmp2 is required for cephalic neural tube closure in the mouse.	BMP4 OTX2	5.19e-05	8	48	2	19097048
Pubmed	Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT.	UGT2B4 UGT2B10	5.19e-05	8	48	2	32093886
Pubmed	Linkage analysis of 84 microsatellite markers in intra- and interspecific backcrosses.	LCK SLC2A4	5.19e-05	8	48	2	1643308
Pubmed	The orphan steroid receptor Nur77 family member Nor-1 is essential for early mouse embryogenesis.	BMP4 OTX2	5.19e-05	8	48	2	13129926
Pubmed	Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine.	UGT2B4 UGT2B10	5.19e-05	8	48	2	10748067
Pubmed	Eya1 gene dosage critically affects the development of sensory epithelia in the mammalian inner ear.	BMP4 OTX2	5.19e-05	8	48	2	18678597
Pubmed	Targeted gene disruption of methionine aminopeptidase 2 results in an embryonic gastrulation defect and endothelial cell growth arrest.	BMP4 OTX2	5.19e-05	8	48	2	16790550
Pubmed	Axis development and early asymmetry in mammals.	BMP4 OTX2	6.67e-05	9	48	2	9988215
Pubmed	Otx1 and Otx2 activities are required for the normal development of the mouse inner ear.	BMP4 OTX2	6.67e-05	9	48	2	10225993
Pubmed	exma: an X-linked insertional mutation that disrupts forebrain and eye development.	OTX2 ZFY	6.67e-05	9	48	2	11956759
Pubmed	Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear.	BMP4 OTX2	6.67e-05	9	48	2	17395647
Pubmed	Reproductive dysfunction and decreased GnRH neurogenesis in a mouse model of CHARGE syndrome.	BMP4 OTX2	6.67e-05	9	48	2	21596839
Pubmed	Mouse Tenm4 is required for mesoderm induction.	BMP4 OTX2	8.33e-05	10	48	2	23521771
Pubmed	Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse.	BMP4 OTX2 GDF6	1.01e-04	65	48	3	33795231
Pubmed	Transcription factor AP-2gamma is essential in the extra-embryonic lineages for early postimplantation development.	BMP4 OTX2	1.02e-04	11	48	2	12015300
Pubmed	Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo.	BMP4 OTX2	1.02e-04	11	48	2	9529255
Pubmed	Wtap is required for differentiation of endoderm and mesoderm in the mouse embryo.	BMP4 OTX2	1.02e-04	11	48	2	18224709
Pubmed	Bmp4 from the optic vesicle specifies murine retina formation.	BMP4 GDF6	1.02e-04	11	48	2	25792196
Pubmed	Induction of the mammalian node requires Arkadia function in the extraembryonic lineages.	OTX2 RNF111	1.22e-04	12	48	2	11298452
Pubmed	Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity.	BMP4 OTX2	1.22e-04	12	48	2	11291865
Pubmed	TBX1 is required for inner ear morphogenesis.	BMP4 OTX2	1.22e-04	12	48	2	12913075
Pubmed	Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.	DUSP14 PPP1R8 PPME1 TNS2 ACACB SDHA	1.33e-04	573	48	6	28330616
Pubmed	Wnt-dependent regulation of inner ear morphogenesis is balanced by the opposing and supporting roles of Shh.	BMP4 OTX2	1.44e-04	13	48	2	15961523
Pubmed	The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo.	BMP4 OTX2	1.44e-04	13	48	2	16368929
Pubmed	BMP4 is essential for lens induction in the mouse embryo.	BMP4 OTX2	1.44e-04	13	48	2	9851982
Pubmed	Kinked tail mutation results in notochord defects in heterozygotes and distal visceral endoderm defects in homozygotes.	BMP4 OTX2	1.44e-04	13	48	2	19877283
Pubmed	Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation.	BMP4 OTX2	1.44e-04	13	48	2	19841259
Pubmed	Conserved role of Sonic Hedgehog in tonotopic organization of the avian basilar papilla and mammalian cochlea.	BMP4 OTX2	1.44e-04	13	48	2	25775517
Pubmed	Ino80 is essential for proximal-distal axis asymmetry in part by regulating Bmp4 expression.	BMP4 OTX2	1.68e-04	14	48	2	26975355
Pubmed	Nuclear receptor NR5A2 is required for proper primitive streak morphogenesis.	BMP4 OTX2	1.68e-04	14	48	2	17075876
Pubmed	Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis.	BMP4 OTX2	1.68e-04	14	48	2	14633973
Pubmed	Stabilization of beta-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast.	BMP4 OTX2	1.68e-04	14	48	2	15525667
Pubmed	Phenotypical analysis of atypical PKCs in vivo function display a compensatory system at mouse embryonic day 7.5.	BMP4 OTX2	1.68e-04	14	48	2	23690951
Pubmed	Fgf3 is required for dorsal patterning and morphogenesis of the inner ear epithelium.	BMP4 OTX2	1.68e-04	14	48	2	17855431
Pubmed	Identification of Genes With Enriched Expression in Early Developing Mouse Cone Photoreceptors.	OTX2 EPHA8	1.94e-04	15	48	2	31260032
Pubmed	Tbx1 regulates population, proliferation and cell fate determination of otic epithelial cells.	BMP4 OTX2	1.94e-04	15	48	2	17074316
Pubmed	Requirement for beta-catenin in anterior-posterior axis formation in mice.	BMP4 OTX2	1.94e-04	15	48	2	10662781
Pubmed	Requirement for Wnt3 in vertebrate axis formation.	BMP4 OTX2	1.94e-04	15	48	2	10431240
Pubmed	Otx2 is required for visceral endoderm movement and for the restriction of posterior signals in the epiblast of the mouse embryo.	BMP4 OTX2	1.94e-04	15	48	2	11171400
Pubmed	Multiple roles for Nodal in the epiblast of the mouse embryo in the establishment of anterior-posterior patterning.	BMP4 OTX2	1.94e-04	15	48	2	15302604
Pubmed	Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers.	BMP4 OTX2	2.21e-04	16	48	2	16613831
Pubmed	Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks.	BMP4 OTX2	2.21e-04	16	48	2	12431380
Pubmed	Bmp5/7 in concert with the mid-hindbrain organizer control development of noradrenergic locus coeruleus neurons.	BMP4 OTX2	2.21e-04	16	48	2	20493948
Pubmed	Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signaling.	BMP4 OTX2	2.21e-04	16	48	2	15829521
Pubmed	The mouse Ovol2 gene is required for cranial neural tube development.	BMP4 OTX2	2.21e-04	16	48	2	16423343
Pubmed	Loss of function of mouse Pax-Interacting Protein 1-associated glutamate rich protein 1a (Pagr1a) leads to reduced Bmp2 expression and defects in chorion and amnion development.	BMP4 OTX2	2.21e-04	16	48	2	24633704
Pubmed	The role of Pax2 in mouse inner ear development.	BMP4 OTX2	2.50e-04	17	48	2	15242798
Pubmed	Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity.	BMP4 OTX2	2.50e-04	17	48	2	12581525
Pubmed	Esrrb function is required for proper primordial germ cell development in presomite stage mouse embryos.	BMP4 OTX2	2.50e-04	17	48	2	31315026
Pubmed	Six1 controls patterning of the mouse otic vesicle.	BMP4 OTX2	2.50e-04	17	48	2	14695375
Pubmed	Lhx2 is required for patterning and expansion of a distinct progenitor cell population committed to eye development.	BMP4 OTX2	2.50e-04	17	48	2	21886788
Pubmed	Targeted mutagenesis of the Hira gene results in gastrulation defects and patterning abnormalities of mesoendodermal derivatives prior to early embryonic lethality.	BMP4 OTX2	2.50e-04	17	48	2	11884616
Pubmed	GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion.	BMP4 OTX2	2.50e-04	17	48	2	17634284
Pubmed	Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation.	BMP4 OTX2	2.50e-04	17	48	2	20040491
Pubmed	A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.	IGSF9B TENM3 EPHA8	2.75e-04	91	48	3	28558017
Pubmed	Epiblast-specific loss of HCF-1 leads to failure in anterior-posterior axis specification.	BMP4 OTX2	2.81e-04	18	48	2	27521049
Pubmed	Glucose transporter gene expression in early mouse embryos.	LCK SLC2A4	2.81e-04	18	48	2	1765007
Pubmed	Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development.	BMP4 OTX2	2.81e-04	18	48	2	17936261
Pubmed	Nodal signalling in the epiblast patterns the early mouse embryo.	BMP4 OTX2	2.81e-04	18	48	2	11418863
Pubmed	The docking protein FRS2alpha is an essential component of multiple fibroblast growth factor responses during early mouse development.	BMP4 OTX2	2.81e-04	18	48	2	15870281
Pubmed	Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and patterning in the mouse embryo.	BMP4 OTX2	2.81e-04	18	48	2	15084457
Pubmed	The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo.	BMP4 OTX2	2.81e-04	18	48	2	12091315
Pubmed	Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.	ACACB PTGS1 SDHA	2.93e-04	93	48	3	27689697
Pubmed	Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling.	UBE2J1 ABHD13 HMGCR TMEM9	3.13e-04	235	48	4	32614325
Pubmed	SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression.	BMP4 HMGCR	3.14e-04	19	48	2	26685326
Pubmed	Requirement for Lmo4 in the vestibular morphogenesis of mouse inner ear.	BMP4 OTX2	3.14e-04	19	48	2	19913004
Pubmed	Gli3 is required for Emx gene expression during dorsal telencephalon development.	BMP4 OTX2	3.14e-04	19	48	2	10409502
Pubmed	Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors.	BMP4 OTX2	3.14e-04	19	48	2	20596238
Pubmed	Proper patterning of the optic fissure requires the sequential activity of BMP7 and SHH.	BMP4 OTX2	3.49e-04	20	48	2	16854970
Pubmed	Loss of the extraembryonic ectoderm in Elf5 mutants leads to defects in embryonic patterning.	BMP4 OTX2	3.49e-04	20	48	2	15829518
Pubmed	Porcn-dependent Wnt signaling is not required prior to mouse gastrulation.	BMP4 OTX2	3.49e-04	20	48	2	23760955
Pubmed	HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo.	BMP4 OTX2	3.49e-04	20	48	2	10498685
Pubmed	Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development.	NDST4 BMP4	3.49e-04	20	48	2	17107998
Pubmed	Extraembryonic proteases regulate Nodal signalling during gastrulation.	BMP4 OTX2	3.85e-04	21	48	2	12447384
Pubmed	Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo.	BMP4 OTX2	3.85e-04	21	48	2	10421635
Pubmed	Sall4 isoforms act during proximal-distal and anterior-posterior axis formation in the mouse embryo.	BMP4 OTX2	3.85e-04	21	48	2	18781635
Pubmed	Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	TNS2 IGSF9B DOCK9	4.07e-04	104	48	3	10470851
Pubmed	The Wheels mutation in the mouse causes vascular, hindbrain, and inner ear defects.	BMP4 OTX2	4.23e-04	22	48	2	11356033
Pubmed	Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).	ACACB SLC2A4	4.23e-04	22	48	2	20965718
Pubmed	Ets2 is necessary in trophoblast for normal embryonic anteroposterior axis development.	BMP4 OTX2	4.23e-04	22	48	2	16481355
Pubmed	Specification of the mammalian cochlea is dependent on Sonic hedgehog.	BMP4 OTX2	4.23e-04	22	48	2	12231626
Pubmed	Cripto-independent Nodal signaling promotes positioning of the A-P axis in the early mouse embryo.	BMP4 OTX2	4.23e-04	22	48	2	18241853
Pubmed	NDST1-dependent heparan sulfate regulates BMP signaling and internalization in lung development.	NDST4 BMP4	4.23e-04	22	48	2	19299468
Cytoband	17q21	AOC2 CNTNAP1 AOC3	4.08e-05	63	48	3	17q21
Cytoband	Ensembl 112 genes in cytogenetic band chr17q21	B4GALNT2 AOC2 CNTNAP1 AOC3	1.51e-03	473	48	4	chr17q21
GeneFamily	UDP glucuronosyltransferases	UGT2B4 UGT2B10 UGT3A2	3.17e-05	32	35	3	363
Drug	isopentenyladenine	HMGCR SDHA AOC2 AOC3	1.38e-06	40	47	4	CID000092180
Drug	isobutylamine	BLVRB B4GALNT2 AOC3	1.79e-06	12	47	3	CID000006558
Drug	diphenylglyoxal bis(guanylhydrazone	AOC2 AOC3	4.17e-06	2	47	2	CID000357080
Drug	AC1Q77R6	AOC2 AOC3	4.17e-06	2	47	2	CID000094259
Drug	DPGBG	AOC2 AOC3	4.17e-06	2	47	2	CID005356884
Drug	monopropionylcadaverine	AOC2 AOC3	4.17e-06	2	47	2	CID000194207
Drug	p-dimethylaminomethylbenzaldehyde	AOC2 AOC3	4.17e-06	2	47	2	CID000193251
Drug	1-carboxymethylpyridinium	AOC2 AOC3	4.17e-06	2	47	2	CID000080439
Drug	isoputreanine	AOC2 AOC3	4.17e-06	2	47	2	CID000171763
Drug	supinidine	AOC2 AOC3	4.17e-06	2	47	2	CID000164663
Drug	N-(3-aminopropyl)pyrrolidin-2-one	AOC2 AOC3	4.17e-06	2	47	2	CID000082111
Drug	AC1L1B7L	AOC2 AOC3	1.25e-05	3	47	2	CID000026477
Drug	3-aminopropionamide	AOC2 AOC3	1.25e-05	3	47	2	CID000192802
Drug	pentafluorobenzamide	AOC2 AOC3	1.25e-05	3	47	2	CID000069547
Drug	acisoga	AOC2 AOC3	1.25e-05	3	47	2	CID000129397
Drug	(+)-Cyanustine	AOC2 AOC3	1.25e-05	3	47	2	CID000028846
Drug	propylglyoxal	AOC2 AOC3	1.25e-05	3	47	2	CID000123249
Drug	3-Hydroxycadaverine	AOC2 AOC3	1.25e-05	3	47	2	CID000435285
Drug	5-fluoropentane-1,4-diamine	AOC2 AOC3	1.25e-05	3	47	2	CID010011890
Drug	NSD-1531	AOC2 AOC3	1.25e-05	3	47	2	CID003014318
Drug	Nazlinine	AOC2 AOC3	1.25e-05	3	47	2	CID000126237
Drug	5-aminopentanal	AOC2 AOC3	1.25e-05	3	47	2	CID000443849
Drug	necic acid	AOC2 AOC3	1.25e-05	3	47	2	CID006440847
Drug	AC1L34PU	AOC2 AOC3	1.25e-05	3	47	2	CID000134498
Drug	manganese protoporphyrin	HMGCR PTGS1	1.25e-05	3	47	2	ctd:C038654
Drug	h202	AOC2 AOC3	1.25e-05	3	47	2	CID000013826
Drug	amicarbalide	AOC2 AOC3	1.25e-05	3	47	2	CID000072074
Drug	N-(4-aminobutyl)aziridine	AOC2 AOC3	1.25e-05	3	47	2	CID000152643
Drug	C10974	AOC2 AOC3	1.25e-05	3	47	2	CID000443042
Drug	alpha-difluoromethyl putrescine	AOC2 AOC3	1.25e-05	3	47	2	CID000135151
Drug	ketosuccinamate	AOC2 AOC3	1.25e-05	3	47	2	CID000439716
Drug	N-(3-aminopropyl)aziridine	AOC2 AOC3	1.25e-05	3	47	2	CID000014076
Drug	ethylmethylglyoxal bis(guanylhydrazone	AOC2 AOC3	1.25e-05	3	47	2	CID000129202
Drug	malonamate	AOC2 AOC3	2.50e-05	4	47	2	CID000075367
Drug	2-aminoresorcinol	AOC2 AOC3	2.50e-05	4	47	2	CID000069450
Drug	Eovist (TN)	AOC2 AOC3	2.50e-05	4	47	2	CID009961939
Drug	AC1Q3E6A	AOC2 AOC3	2.50e-05	4	47	2	CID000068318
Drug	spermic acid	AOC2 AOC3	2.50e-05	4	47	2	CID000167029
Drug	N-acetyl-1,6-diaminohexane	AOC2 AOC3	2.50e-05	4	47	2	CID000162081
Drug	3-aminooxy-2-fluoro-1-propanamine	AOC2 AOC3	2.50e-05	4	47	2	CID000126496
Drug	2-Butene-1,4-diamine	AOC2 AOC3	2.50e-05	4	47	2	CID000148401
Drug	lanthionamine	AOC2 AOC3	2.50e-05	4	47	2	CID000070096
Drug	N-methylpyrrolinium	AOC2 AOC3	2.50e-05	4	47	2	CID000440932
Drug	dimethylpyridine	AOC2 AOC3	2.50e-05	4	47	2	CID000011420
Drug	1,4-diamino-2-butyne	AOC2 AOC3	2.50e-05	4	47	2	CID000124159
Drug	Cerebro	POMT2 LAMA5 MGAT5	2.60e-05	28	47	3	CID000005354
Drug	tyrosine	PTGS1 AOC2 AOC3	2.90e-05	29	47	3	CID005460802
Drug	Ascorbic Acid	BMP4 HMGCR LCK SOX13 PTGS1 SDHA SLC2A4 CNTNAP1	3.90e-05	628	47	8	ctd:D001205
Drug	piperideine	AOC2 AOC3	4.15e-05	5	47	2	CID000068161
Drug	geranylamine	AOC2 AOC3	4.15e-05	5	47	2	CID000160248
Drug	phenamidine	AOC2 AOC3	4.15e-05	5	47	2	CID000064948
Drug	NSD 1039	AOC2 AOC3	4.15e-05	5	47	2	CID000193408
Drug	NSD 1024	AOC2 AOC3	4.15e-05	5	47	2	CID000188951
Drug	N(8)-(2-carboxyethyl)spermidine	AOC2 AOC3	4.15e-05	5	47	2	CID000125245
Drug	Nsc82118	AOC2 AOC3	4.15e-05	5	47	2	CID000164749
Drug	oxosparteine	AOC2 AOC3	4.15e-05	5	47	2	CID000097492
Drug	alpha-hydrazinohistidine	AOC2 AOC3	4.15e-05	5	47	2	CID000169499
Drug	perhydroazepinyl	AOC2 AOC3	4.15e-05	5	47	2	CID000123152
Drug	2-fluoroputrescine	AOC2 AOC3	4.15e-05	5	47	2	CID000147066
Drug	pelletierine	AOC2 AOC3	4.15e-05	5	47	2	CID000092987
Drug	1,4-diamino-2-butanone	AOC2 AOC3	4.15e-05	5	47	2	CID000151733
Drug	GGTI-286	HMGCR PTGS1 SDHA	5.15e-05	35	47	3	CID003012116
Drug	norspermidine	HMGCR AOC2 AOC3	5.15e-05	35	47	3	CID000005942
Drug	agmatine	B4GALNT2 LCK AOC2 AOC3	5.84e-05	102	47	4	CID000000199
Drug	Olan	HMGCR SDHA	6.22e-05	6	47	2	CID000189047
Drug	NSC614854	AOC2 AOC3	6.22e-05	6	47	2	CID000122633
Drug	isothiouronium	AOC2 AOC3	6.22e-05	6	47	2	CID000031429
Drug	trihydroxyphenylalanine	AOC2 AOC3	6.22e-05	6	47	2	CID000591034
Drug	cyclohexanone oxime	AOC2 AOC3	6.22e-05	6	47	2	CID000007517
Drug	2-hydroxyestriol	UGT2B4 UGT2B10	6.22e-05	6	47	2	CID000014688
Drug	ethylglyoxal	AOC2 AOC3	6.22e-05	6	47	2	CID000145744
Drug	FF-705	AOC2 AOC3	6.22e-05	6	47	2	CID000126643
Drug	1,4-dimethylputrescine	AOC2 AOC3	6.22e-05	6	47	2	CID000162247
Drug	Fe(III)EDTA	BLVRB LCK AOC3	8.32e-05	41	47	3	CID000028283
Drug	putreanine	AOC2 AOC3	8.70e-05	7	47	2	CID000161506
Drug	AC1L3Y6U	AOC2 AOC3	8.70e-05	7	47	2	CID000097282
Drug	GYKI 11.121	AOC2 AOC3	8.70e-05	7	47	2	CID000193769
Drug	p-dimethylaminomethylbenzylamine	AOC2 AOC3	8.70e-05	7	47	2	CID000193714
Drug	2-hydrazinopyridine	AOC2 AOC3	8.70e-05	7	47	2	CID000078645
Drug	AC1L28PE	AOC2 AOC3	8.70e-05	7	47	2	CID000067954
Drug	NADP(H	UGT2B4 UGT2B10 BLVRB PPP1R8 HMGCR KMO SDHA	9.65e-05	527	47	7	CID000000930
Drug	hyamine hydroxide	AOC2 AOC3	1.16e-04	8	47	2	CID000014842
Drug	1,2-diaminoguanidine	AOC2 AOC3	1.16e-04	8	47	2	CID000170039
Drug	NSC-356893	AOC2 AOC3	1.16e-04	8	47	2	CID000434770
Drug	Z H-H	AOC2 AOC3	1.16e-04	8	47	2	CID000004657
Drug	Q 192	AOC2 AOC3	1.16e-04	8	47	2	CID000077317
Drug	dolichols	POMT2 HMGCR MGAT5 SDHA	1.17e-04	122	47	4	CID000439223
Drug	salicylamide	UGT2B4 UGT2B10 PTGS1	1.34e-04	48	47	3	CID000005147
Drug	imidazole	UGT2B4 UGT2B10 PTGS1 AOC2 AOC3	1.39e-04	242	47	5	CID000000795
Drug	p-nitrophenylhydrazine	AOC2 AOC3	1.49e-04	9	47	2	CID000069472
Drug	Lilly 51641	AOC2 AOC3	1.49e-04	9	47	2	CID000021485
Drug	Farnezylacetone	PTGS1 SDHA	1.49e-04	9	47	2	CID000061206
Drug	4-acetamidobutyrate	AOC2 AOC3	1.49e-04	9	47	2	CID000018189
Drug	copper glycinate	AOC2 AOC3	1.49e-04	9	47	2	CID000424155
Drug	AC1L96SZ	POMT2 MGAT5 SDHA	1.51e-04	50	47	3	CID000439166
Drug	acetylcadaverine	AOC2 AOC3	1.86e-04	10	47	2	CID000189087
Drug	6-hydroxydopa	AOC2 AOC3	1.86e-04	10	47	2	CID000033755
Drug	AC1O5218	BLVRB SDHA	1.86e-04	10	47	2	CID006475722
Drug	3-dimethylaminobenzoic acid	AOC2 AOC3	1.86e-04	10	47	2	CID000066837
Drug	isoxazolidine	HMGCR GRHL2	1.86e-04	10	47	2	CID000136333
Disease	platelet-activating factor measurement	ABT1 IQCM	2.27e-05	5	45	2	EFO_0801075
Disease	autosomal recessive limb-girdle muscular dystrophy (is_implicated_in)	POMT2 HMGCR	2.27e-05	5	45	2	DOID:0110274 (is_implicated_in)
Disease	vanillylmandelate (VMA) measurement	UGT2B4 UGT2B10	4.75e-05	7	45	2	EFO_0800119
Disease	Microphthalmia associated with colobomatous cyst	TENM3 GDF6	6.33e-05	8	45	2	C2931501
Disease	plasma clozapine-to-N-desmethylclozapine ratio measurement	UGT2B4 UGT2B10	8.13e-05	9	45	2	EFO_0600040
Disease	Asthma, Occupational	TENM3 PTGS1	1.02e-04	10	45	2	C0264423
Disease	cleft lip (is_implicated_in)	BMP4 GDF6	2.36e-04	15	45	2	DOID:9296 (is_implicated_in)
Disease	free cholesterol measurement, very low density lipoprotein cholesterol measurement	HMGCR MGAT5 ACACB RNF111	3.23e-04	215	45	4	EFO_0008317, EFO_0008591
Disease	very low density lipoprotein cholesterol measurement, lipid measurement	HMGCR MGAT5 ACACB RNF111	3.53e-04	220	45	4	EFO_0004529, EFO_0008317
Disease	cholesteryl ester measurement, very low density lipoprotein cholesterol measurement	HMGCR MGAT5 ACACB RNF111	3.84e-04	225	45	4	EFO_0008317, EFO_0010351
Disease	very low density lipoprotein cholesterol measurement, phospholipid measurement	HMGCR MGAT5 ACACB RNF111	4.10e-04	229	45	4	EFO_0004639, EFO_0008317
Disease	opioid dependence	ABT1 MGAT5 PTGS1 RNF111	4.67e-04	237	45	4	EFO_0005611
Disease	Anophthalmia-microphthalmia syndrome	BMP4 OTX2	4.69e-04	21	45	2	cv:C5680330
Disease	type 2 diabetes mellitus (implicated_via_orthology)	HMGCR SLC2A4 AOC3	5.57e-04	105	45	3	DOID:9352 (implicated_via_orthology)
Disease	very low density lipoprotein cholesterol measurement	HMGCR MGAT5 ACACB RNF111	6.61e-04	260	45	4	EFO_0008317
Disease	uromodulin measurement	B4GALNT2 MGAT5	7.22e-04	26	45	2	EFO_0021778
Disease	Nephrotic Syndrome	LAMA5 TNS2	7.79e-04	27	45	2	C0027726

Protein segments in the cluster

Peptide	Gene	Start	Entry
LYVPMPTGIPHENIF	ABHD13	76	Q7L211
LPGEGIMPHEDGPLY	ALKBH6	106	Q3KRA9
HMLSRPVPGYEPGYI	CNTNAP1	1026	P78357
PNLPFGYPVHGVEVM	B4GALNT2	191	Q8NHY0
YVAVMPPHIGDQPLT	BLVRB	146	P30043
VPLADMPHAPIGLYF	DUSP14	76	O95147
GTQPPGKMEYHLIPH	DTX4	476	Q9Y2E6
YEVMKPPAEVVPGHL	BMP4	181	P12644
LVVGPLPHPSYMRDV	AOC3	141	Q16853
EMLFTLYPPEGAHVP	IQCM	426	A0A1B0GVH7
AMYGDLPPPIMLIGH	PPME1	141	Q9Y570
IKMADHYVPVPGGPN	ACACB	311	O00763
ELVVGPLPHPSYMRD	AOC2	136	O75106
VLPPMDGYPHCEGKI	MGAT5	146	Q09328
VPMYVGEIAPTHLRG	SLC2A4	156	P14672
IGYMPIPVGVAGPLC	HMGCR	531	P04035
IYEVAIVGPIHPGME	FAT2	1876	Q9NYQ8
HGRIPYPGMTNPEVI	LCK	436	P06239
APLYLGGLPEPMAVQ	LAMA5	3641	O15230
YHMVIAPGKGDIPPL	NDST4	106	Q9H3R1
ARDTEMHPIPYPGGV	OR1I1	331	O60431
EEAPVLMHYPRGIPP	PTGS1	266	P23219
YLLTHPPPIMGGVVR	HUWE1	1351	Q7Z6Z7
MVGPDVIPLPHIYGA	FAM189A2	166	Q15884
KRVVPGIVYLGHIPP	ABT1	41	Q9ULW3
VFMAPPVHYPRGDGE	GRHL2	166	Q6ISB3
PHGYMELTIPPKNGD	KMO	191	O15229
EHYIPLNLPMPFGKG	DOCK9	1076	Q9BZ29
VEEGYRLPAPMGCPH	EPHA8	851	P29322
VVAPHNGYPVTPGIM	MS4A8	16	Q9BY19
NGYPVTPGIMSHVPL	MS4A8	21	Q9BY19
ILQAGDGPPQMRPYH	ARHGAP30	256	Q7Z6I6
GMDLLHPSVGYPATP	OTX2	21	P32243
PGRGPRVVPHEYMLS	GDF6	86	Q6KF10
IHGTALIGGLPMPYP	PPP1R8	281	Q12972
HPLAYGMVGPLAQDP	POMT2	721	Q9UKY4
PVLPTVHYNMGGIPT	SDHA	401	P31040
PMPVPGHDVEAYCLL	TMEM9	61	Q9P0T7
GMPLAQPLVEHYVPR	SOX13	551	Q9UN79
ALPLMVPDMAGYPHI	RNF111	846	Q6ZNA4
HGIPMVGVPLFADQP	UGT2B4	386	P06133
RHTSQGMGIPVLPYP	IGSF9B	1136	Q9UPX0
GVYHGRIVLPPEYPM	UBE2J1	56	Q9Y385
PMHCQVPGVEYPVGK	TENM3	1381	Q9P273
EAIYHGIPMVGIPLF	UGT2B10	381	P36537
HMEVMPLFAGYLPLP	TRAPPC10	1146	P48553
HGVPMVGIPLFGDQP	UGT3A2	381	Q3SY77
YVLIPMLPAFEPGTG	TNS2	306	Q63HR2
PQLIHGRDYEMVPEP	USP32	551	Q8NFA0
IGPDGHPLTVYPCMI	ZFY	411	P08048