Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	N-acetyllactosamine synthase activity	B4GALT4 B4GALT3	4.10e-05	5	41	2	GO:0003945
GeneOntologyBiologicalProcess	glycolipid biosynthetic process	FUT2 GPAA1 B4GALT4 B4GALT3	2.00e-05	81	41	4	GO:0009247
GeneOntologyBiologicalProcess	glycosphingolipid biosynthetic process	FUT2 B4GALT4 B4GALT3	7.37e-05	41	41	3	GO:0006688
GeneOntologyBiologicalProcess	response to hydrostatic pressure	PLEC NTRK1	8.04e-05	7	41	2	GO:0051599
GeneOntologyBiologicalProcess	glycolipid metabolic process	FUT2 GPAA1 B4GALT4 B4GALT3	9.04e-05	119	41	4	GO:0006664
GeneOntologyBiologicalProcess	liposaccharide metabolic process	FUT2 GPAA1 B4GALT4 B4GALT3	9.34e-05	120	41	4	GO:1903509
GeneOntologyBiologicalProcess	maintenance of protein localization in organelle	GPAA1 SYNE1 PGR	1.11e-04	47	41	3	GO:0072595
GeneOntologyBiologicalProcess	maintenance of location in cell	CHERP GPAA1 SYNE1 RYR3 PGR	1.56e-04	259	41	5	GO:0051651
GeneOntologyBiologicalProcess	cilium assembly	GMNC PTPN23 SYNE1 NISCH PCM1 CEP290	2.28e-04	444	41	6	GO:0060271
GeneOntologyBiologicalProcess	regulation of Ras protein signal transduction	RASA4B RASA4 NTRK1	2.42e-04	61	41	3	GO:0046578
GeneOntologyBiologicalProcess	membrane lipid biosynthetic process	FUT2 GPAA1 B4GALT4 B4GALT3	2.63e-04	157	41	4	GO:0046467
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection assembly	GMNC PTPN23 MAP4K4 SYNE1 NISCH PCM1 CEP290	3.18e-04	670	41	7	GO:0120031
GeneOntologyBiologicalProcess	cilium organization	GMNC PTPN23 SYNE1 NISCH PCM1 CEP290	3.32e-04	476	41	6	GO:0044782
GeneOntologyBiologicalProcess	response to water	PLEC NTRK1	3.46e-04	14	41	2	GO:0009415
GeneOntologyBiologicalProcess	cell projection assembly	GMNC PTPN23 MAP4K4 SYNE1 NISCH PCM1 CEP290	3.63e-04	685	41	7	GO:0030031
GeneOntologyBiologicalProcess	glycosphingolipid metabolic process	FUT2 B4GALT4 B4GALT3	4.12e-04	73	41	3	GO:0006687
GeneOntologyBiologicalProcess	maintenance of protein location in cell	GPAA1 SYNE1 PGR	4.63e-04	76	41	3	GO:0032507
GeneOntologyBiologicalProcess	regulation of GTPase activity	RASA4B TSC1 MAP4K4 RASA4 NTRK1	5.09e-04	335	41	5	GO:0043087
HumanPheno	Bilateral facial palsy	PLEC SYNE1	1.80e-05	3	13	2	HP:0430025
Domain	-	RASA4B RASA4	1.48e-05	3	42	2	4.10.1130.10
Domain	Leu-rich_rpt	LRRC28 MFHAS1 PXDNL NTRK1 ECM2 NISCH	2.99e-05	271	42	6	IPR001611
Domain	LRR_8	LRRC28 MFHAS1 PXDNL NTRK1 ECM2	3.92e-05	171	42	5	PF13855
Domain	-	LRRC28 MFHAS1 PXDNL NTRK1 ECM2 NISCH	7.66e-05	321	42	6	3.80.10.10
Domain	L_dom-like	LRRC28 MFHAS1 PXDNL NTRK1 ECM2 NISCH	8.63e-05	328	42	6	IPR032675
Domain	Galactosyl_T	B4GALT4 B4GALT3	1.03e-04	7	42	2	IPR003859
Domain	Galactosyl_T_C	B4GALT4 B4GALT3	1.03e-04	7	42	2	IPR027791
Domain	Galactosyl_T_N	B4GALT4 B4GALT3	1.03e-04	7	42	2	IPR027995
Domain	Glyco_transf_7C	B4GALT4 B4GALT3	1.03e-04	7	42	2	PF02709
Domain	Glyco_transf_7N	B4GALT4 B4GALT3	1.03e-04	7	42	2	PF13733
Domain	LRR_1	LRRC28 MFHAS1 PXDNL ECM2 NISCH	1.27e-04	219	42	5	PF00560
Domain	BTK	RASA4B RASA4	1.76e-04	9	42	2	SM00107
Domain	ZF_BTK	RASA4B RASA4	1.76e-04	9	42	2	PS51113
Domain	Znf_Btk_motif	RASA4B RASA4	1.76e-04	9	42	2	IPR001562
Domain	BTK	RASA4B RASA4	1.76e-04	9	42	2	PF00779
Domain	RasGAP	RASA4B RASA4	4.42e-04	14	42	2	SM00323
Domain	RasGAP_CS	RASA4B RASA4	4.42e-04	14	42	2	IPR023152
Domain	RAS_GTPASE_ACTIV_2	RASA4B RASA4	5.09e-04	15	42	2	PS50018
Domain	RasGAP	RASA4B RASA4	5.09e-04	15	42	2	PF00616
Domain	RAS_GTPASE_ACTIV_1	RASA4B RASA4	5.09e-04	15	42	2	PS00509
Domain	-	RASA4B RASA4	5.81e-04	16	42	2	1.10.506.10
Domain	Leu-rich_rpt_typical-subtyp	LRRC28 MFHAS1 PXDNL ECM2	6.59e-04	177	42	4	IPR003591
Domain	LRR_TYP	LRRC28 MFHAS1 PXDNL ECM2	6.59e-04	177	42	4	SM00369
Domain	RasGAP_dom	RASA4B RASA4	7.38e-04	18	42	2	IPR001936
Domain	LRR	MFHAS1 PXDNL ECM2 NISCH	1.06e-03	201	42	4	PS51450
Domain	Actinin_actin-bd_CS	PLEC SYNE1	1.21e-03	23	42	2	IPR001589
Domain	ACTININ_2	PLEC SYNE1	1.21e-03	23	42	2	PS00020
Domain	ACTININ_1	PLEC SYNE1	1.21e-03	23	42	2	PS00019
Domain	Helicase_C	CHD3 DHX58 ERCC6L	1.78e-03	107	42	3	PF00271
Domain	HELICc	CHD3 DHX58 ERCC6L	1.78e-03	107	42	3	SM00490
Domain	VWC	PXDNL ECM2	1.80e-03	28	42	2	PF00093
Domain	Helicase_C	CHD3 DHX58 ERCC6L	1.83e-03	108	42	3	IPR001650
Domain	HELICASE_CTER	CHD3 DHX58 ERCC6L	1.88e-03	109	42	3	PS51194
Domain	HELICASE_ATP_BIND_1	CHD3 DHX58 ERCC6L	1.88e-03	109	42	3	PS51192
Domain	DEXDc	CHD3 DHX58 ERCC6L	1.88e-03	109	42	3	SM00487
Domain	Spectrin_repeat	PLEC SYNE1	1.93e-03	29	42	2	IPR002017
Domain	Helicase_ATP-bd	CHD3 DHX58 ERCC6L	1.93e-03	110	42	3	IPR014001
Domain	SNF2_N	CHD3 ERCC6L	2.35e-03	32	42	2	PF00176
Domain	SNF2_N	CHD3 ERCC6L	2.35e-03	32	42	2	IPR000330
Domain	Spectrin/alpha-actinin	PLEC SYNE1	2.35e-03	32	42	2	IPR018159
Domain	SPEC	PLEC SYNE1	2.35e-03	32	42	2	SM00150
Domain	VWFC_1	PXDNL ECM2	2.96e-03	36	42	2	PS01208
Domain	VWC	PXDNL ECM2	3.30e-03	38	42	2	SM00214
Domain	VWFC_2	PXDNL ECM2	3.30e-03	38	42	2	PS50184
Domain	VWF_dom	PXDNL ECM2	4.02e-03	42	42	2	IPR001007
Domain	TPR-contain_dom	PTPN23 TTC28 ERCC6L	4.63e-03	150	42	3	IPR013026
Domain	TPR	PTPN23 TTC28 ERCC6L	6.04e-03	165	42	3	PS50005
Domain	TPR_REGION	PTPN23 TTC28 ERCC6L	6.04e-03	165	42	3	PS50293
Pathway	WP_NEOLACTO_SERIES_SPHINGOLIPID_METABOLISM	FUT2 B4GALT4 B4GALT3	1.73e-06	11	32	3	M48314
Pathway	KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES	FUT2 B4GALT4 B4GALT3	2.67e-05	26	32	3	M17377
Pathway	KEGG_MEDICUS_REFERENCE_BLOOD_GROUP_H_O_ANTIGEN_TYPE_2_BIOSYNTHESIS	B4GALT4 B4GALT3	1.04e-04	7	32	2	M47965
Pathway	KEGG_MEDICUS_REFERENCE_II_BLOOD_GROUP_ANTIGEN_BIOSYNTHESIS	B4GALT4 B4GALT3	1.04e-04	7	32	2	M47968
Pathway	KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE	B4GALT4 B4GALT3	5.15e-04	15	32	2	M3042
Pathway	REACTOME_N_GLYCAN_ANTENNAE_ELONGATION	B4GALT4 B4GALT3	5.15e-04	15	32	2	M966
Pathway	REACTOME_N_GLYCAN_ANTENNAE_ELONGATION	B4GALT4 B4GALT3	5.15e-04	15	32	2	MM15700
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	PTPN23 TSC1 PLEC TTC28 ACE MAP4K4 NOC2L PCM1 CEP290	6.64e-07	853	42	9	28718761
Pubmed	Beta-1,4-galactosyltransferase-3 deficiency suppresses the growth of immunogenic tumors in mice.	B4GALT4 B4GALT3	1.42e-06	2	42	2	37901252
Pubmed	CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway.	RASA4B RASA4	1.42e-06	2	42	2	11448776
Pubmed	An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.	RASA4B RASA4	1.42e-06	2	42	2	16041389
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	PLEC TTC28 ZNF532 MAP4K4 SYNE1 NISCH PCM1 RYR3 CEP290 B4GALT3	2.29e-06	1285	42	10	35914814
Pubmed	[Genetic study of predisposition to community-acquired pneumonia].	CYP1A1 ACE	4.27e-06	3	42	2	22312901
Pubmed	CD28 inhibits T cell adhesion by recruiting CAPRI to the plasma membrane.	RASA4B RASA4	4.27e-06	3	42	2	25637021
Pubmed	Conditional deletion of Tsc1 in the female reproductive tract impedes normal oviductal and uterine function by enhancing mTORC1 signaling in mice.	TSC1 PGR	4.27e-06	3	42	2	23475984
Pubmed	Functional polymorphisms in the CYP1A1, ACE, and IL-6 genes contribute to susceptibility to community-acquired and nosocomial pneumonia.	CYP1A1 ACE	4.27e-06	3	42	2	23411129
Pubmed	The novel centriolar satellite protein SSX2IP targets Cep290 to the ciliary transition zone.	PCM1 CEP290	4.27e-06	3	42	2	24356449
Pubmed	Polymorphisms in genes involved in sex hormone metabolism, estrogen plus progestin hormone therapy use, and risk of postmenopausal breast cancer.	CYP1A1 PGR	4.27e-06	3	42	2	18628428
Pubmed	Galactosylation of N-linked oligosaccharides by human beta-1,4-galactosyltransferases I, II, III, IV, V, and VI expressed in Sf-9 cells.	B4GALT4 B4GALT3	4.27e-06	3	42	2	11588157
Pubmed	The centriolar satellite protein CCDC66 interacts with CEP290 and functions in cilium formation and trafficking.	PCM1 CEP290	4.27e-06	3	42	2	28235840
Pubmed	Genome-wide association study identifies eight loci associated with blood pressure.	CYP1A1 RHOBTB1 CLCN6	7.93e-06	32	42	3	19430483
Pubmed	Acute versus chronic loss of mammalian Azi1/Cep131 results in distinct ciliary phenotypes.	PCM1 CEP290	8.53e-06	4	42	2	24415959
Pubmed	Mammalian target of rapamycin complex 1 and cyclooxygenase 2 pathways cooperatively exacerbate endometrial cancer.	TSC1 PGR	8.53e-06	4	42	2	25058027
Pubmed	Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities.	RASA4B RASA4	8.53e-06	4	42	2	21460216
Pubmed	CEP290 interacts with the centriolar satellite component PCM-1 and is required for Rab8 localization to the primary cilium.	PCM1 CEP290	8.53e-06	4	42	2	18772192
Pubmed	Identification of an alternatively spliced variant of Ca2+-promoted Ras inactivator as a possible regulator of RANKL shedding.	RASA4B RASA4	8.53e-06	4	42	2	16234249
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	CHD3 DIAPH3 PLEC TTC28 ZNF532 PCM1	1.06e-05	418	42	6	34709266
Pubmed	ACAA2 is a ligand-dependent coactivator for thyroid hormone receptor β1.	PLEC CLCN6 MFHAS1 SYNE1	1.07e-05	113	42	4	34474245
Pubmed	The centriolar satellite protein Cep131 is important for genome stability.	PCM1 CEP290	1.42e-05	5	42	2	22797915
Pubmed	Association of the ACE, GSTM1, IL-6, NOS3, and CYP1A1 polymorphisms with susceptibility of mycoplasma pneumoniae pneumonia in Chinese children.	CYP1A1 ACE	1.42e-05	5	42	2	28403117
Pubmed	A large-scale candidate gene association study of age at menarche and age at natural menopause.	CYP1A1 ACE MFHAS1 PCM1 PGR	2.00e-05	275	42	5	20734064
Pubmed	Genetic polymorphisms in patients with endometriosis: an analytical study in Goiânia (Central West of Brazil).	CYP1A1 PGR	2.13e-05	6	42	2	27323100
Pubmed	Ccdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability.	PCM1 CEP290	2.13e-05	6	42	2	24816561
Pubmed	The expanding beta 4-galactosyltransferase gene family: messages from the databanks.	B4GALT4 B4GALT3	2.13e-05	6	42	2	9597550
Pubmed	Deubiquitylase USP9X maintains centriolar satellite integrity by stabilizing pericentriolar material 1 protein.	PCM1 CEP290	2.13e-05	6	42	2	30584065
Pubmed	TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.	PLEC SYNE1	2.13e-05	6	42	2	18827015
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	TSC1 CHERP TTC28 ERCC6L MAP4K4 PCM1 CEP290	2.55e-05	733	42	7	34672954
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	CHD3 PLEC CHERP MAP4K4 NOC2L SYNE1 PCM1 CEP290	2.67e-05	1024	42	8	24711643
Pubmed	Association between genetic polymorphisms and ovarian cancer risk.	CYP1A1 PGR	2.98e-05	7	42	2	19031960
Pubmed	Comparison of HPLC/ESI-FTICR MS versus MALDI-TOF/TOF MS for glycopeptide analysis of a highly glycosylated HIV envelope glycoprotein.	B4GALT4 B4GALT3	2.98e-05	7	42	2	18565761
Pubmed	In-frame deletion in a novel centrosomal/ciliary protein CEP290/NPHP6 perturbs its interaction with RPGR and results in early-onset retinal degeneration in the rd16 mouse.	PCM1 CEP290	2.98e-05	7	42	2	16632484
Pubmed	Casein kinase 1δ functions at the centrosome and Golgi to promote ciliogenesis.	PCM1 CEP290	3.97e-05	8	42	2	24648492
Pubmed	Comparative genome mapping in the sequence-based era: early experience with human chromosome 7.	RASA4B RASA4	3.97e-05	8	42	2	10810084
Pubmed	Human metabolic individuality in biomedical and pharmaceutical research.	FUT2 GPAA1 ACE	4.58e-05	57	42	3	21886157
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	PTPN23 DIAPH3 TTC28 ERCC6L MAP4K4 PCM1	4.87e-05	549	42	6	38280479
Pubmed	Tethering of an E3 ligase by PCM1 regulates the abundance of centrosomal KIAA0586/Talpid3 and promotes ciliogenesis.	PCM1 CEP290	5.10e-05	9	42	2	27146717
Pubmed	Estrogen sulfation genes, hormone replacement therapy, and endometrial cancer risk.	CYP1A1 PGR	5.10e-05	9	42	2	16985250
Pubmed	Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.	HSPBP1 PLEC MAP4K4 NISCH PCM1 CEP290	5.66e-05	564	42	6	21565611
Pubmed	DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle.	PCM1 CEP290	6.37e-05	10	42	2	27979967
Pubmed	The centriolar satellite protein AZI1 interacts with BBS4 and regulates ciliary trafficking of the BBSome.	PCM1 CEP290	7.78e-05	11	42	2	24550735
Pubmed	Dynamic expression of the TRPM subgroup of ion channels in developing mouse sensory neurons.	TRPM8 NTRK1	9.32e-05	12	42	2	19850157
Pubmed	Etv4 regulates nociception by controlling peptidergic sensory neuron development and peripheral tissue innervation.	TRPM8 NTRK1	1.10e-04	13	42	2	35904071
Pubmed	C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals.	PCM1 CEP290	1.48e-04	15	42	2	24469809
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	PTPN23 CLCN6 TTC28 SYNE1	1.57e-04	225	42	4	12168954
Pubmed	Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions.	B4GALT4 B4GALT3	1.69e-04	16	42	2	10580128
Pubmed	Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women.	CYP1A1 PGR	1.69e-04	16	42	2	19415745
Pubmed	Polymorphisms in genes of the steroid hormone biosynthesis and metabolism pathways and endometrial cancer risk.	CYP1A1 PGR	1.91e-04	17	42	2	20381444
Pubmed	Neurog2 Deficiency Uncovers a Critical Period of Cell Fate Plasticity and Vulnerability among Neural-Crest-Derived Somatosensory Progenitors.	TRPM8 NTRK1	2.40e-04	19	42	2	31801063
Pubmed	Tlx3 and Runx1 act in combination to coordinate the development of a cohort of nociceptors, thermoceptors, and pruriceptors.	TRPM8 NTRK1	2.40e-04	19	42	2	22787056
Pubmed	The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly.	PCM1 CEP290	2.40e-04	19	42	2	24421332
Pubmed	Uncoupling of molecular maturation from peripheral target innervation in nociceptors expressing a chimeric TrkA/TrkC receptor.	TRPM8 NTRK1	2.40e-04	19	42	2	24516396
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	CHD3 DIAPH3 PLEC PCM1	2.58e-04	256	42	4	33397691
Pubmed	Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.	FUT2 SYNE1 NISCH	2.59e-04	102	42	3	21926972
Pubmed	Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation.	TRPM8 NTRK1	2.67e-04	20	42	2	33789102
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	TSC1 CHD3 PLEC CLCN6 HDHD2 SYNE1 NISCH PCM1	2.73e-04	1431	42	8	37142655
Pubmed	A human MAP kinase interactome.	PTPN23 PLEC MAP4K4 SYNE1 CEP290	2.90e-04	486	42	5	20936779
Pubmed	ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons.	TRPM8 NTRK1	2.95e-04	21	42	2	25369838
Pubmed	PRDM16 determines specification of ventricular cardiomyocytes by suppressing alternative cell fates.	PCM1 RYR3	2.95e-04	21	42	2	39304345
Pubmed	Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation.	TRPM8 NTRK1	3.54e-04	23	42	2	20096094
Pubmed	Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain.	TRPM8 NTRK1	3.54e-04	23	42	2	16446141
Pubmed	A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons.	TRPM8 NTRK1	3.86e-04	24	42	2	17553423
Pubmed	Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics.	SYNE1 PCM1	4.20e-04	25	42	2	38877142
Pubmed	Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.	CYP1A1 ACE PGR	4.70e-04	125	42	3	19019335
Pubmed	Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks.	RASA4B TTC28 RASA4	4.81e-04	126	42	3	24319055
Pubmed	Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants.	CYP1A1 ACE PGR	5.03e-04	128	42	3	18818748
Pubmed	Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants.	CYP1A1 ACE PGR	5.03e-04	128	42	3	19527514
Pubmed	Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture.	PCM1 CEP290	6.47e-04	31	42	2	22261722
Pubmed	Proper formation of whisker barrelettes requires periphery-derived Smad4-dependent TGF-beta signaling.	TRPM8 NTRK1	6.47e-04	31	42	2	21300867
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	CHD3 DIAPH3 PLEC CHERP ERCC6L	6.58e-04	582	42	5	20467437
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	TSC1 GID8 DIAPH3 TTC28 PCM1	6.89e-04	588	42	5	38580884
Pubmed	Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA.	TRPM8 NTRK1	7.34e-04	33	42	2	30917309
Pubmed	Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos.	PCM1 B4GALT3	7.79e-04	34	42	2	7490078
Pubmed	Direction selectivity in the retina is established independent of visual experience and cholinergic retinal waves.	TRPM8 NTRK1	8.26e-04	35	42	2	18498732
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	PTPN23 TSC1 CHD3 CHERP ERCC6L PCM1	8.48e-04	934	42	6	33916271
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	SLC47A1 HSPBP1 TMEM143 ERCC6L NOC2L NISCH	8.87e-04	942	42	6	31073040
Pubmed	Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1.	B4GALT4 B4GALT3	9.23e-04	37	42	2	2541446
Pubmed	Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport.	B4GALT4 B4GALT3	9.23e-04	37	42	2	2542563
Pubmed	Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons.	TRPM8 NTRK1	9.23e-04	37	42	2	18498735
Pubmed	Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis.	B4GALT4 B4GALT3	9.74e-04	38	42	2	2829950
Pubmed	Allele frequencies of single nucleotide polymorphisms (SNPs) in 40 candidate genes for gene-environment studies on cancer: data from population-based Japanese random samples.	CYP1A1 PGR	9.74e-04	38	42	2	14634838
Pubmed	Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3).	CYP1A1 PGR	9.74e-04	38	42	2	19574343
Pubmed	Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1.	B4GALT4 B4GALT3	9.74e-04	38	42	2	2187500
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	PTPN23 CLCN6 FBXO21 PCM1 CEP290	1.00e-03	639	42	5	23443559
Pubmed	Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.	DHX58 FBXO21 NISCH B4GALT3	1.04e-03	371	42	4	15747579
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	PTPN23 GID8 HSPBP1 DIAPH3 FBXO21 PCM1	1.05e-03	974	42	6	28675297
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	CHD3 TTC28 ERCC6L MAP4K4 NISCH	1.08e-03	650	42	5	38777146
Pubmed	LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.	NOC2L SYNE1 RYR3	1.11e-03	168	42	3	30631154
Interaction	WWTR1 interactions	PTPN23 DIAPH3 TTC28 ERCC6L MAP4K4 MFHAS1 PCM1	2.04e-05	422	41	7	int:WWTR1
Interaction	TPGS1 interactions	RHOBTB1 NTRK1 PCM1 CEP290	2.19e-05	81	41	4	int:TPGS1
GeneFamily	Pleckstrin homology domain containing\|SH2 domain containing\|C2 and RasGAP domain containing	RASA4B RASA4	9.59e-05	10	27	2	830
GeneFamily	Beta 4-glycosyltransferases	B4GALT4 B4GALT3	2.88e-04	17	27	2	425
Coexpression	GSE22886_TCELL_VS_BCELL_NAIVE_DN	DIAPH3 RHOBTB1 CLCN6 ZNF532 PGR	1.41e-05	198	41	5	M4426
Coexpression	GSE3039_B2_VS_B1_BCELL_UP	CHD3 ACE RYR3 CEP290 B4GALT4	1.44e-05	199	41	5	M6450
Coexpression	HOLLMANN_APOPTOSIS_VIA_CD40_UP	HSPBP1 MAP4K4 MFHAS1 SYNE1 PCM1	1.58e-05	203	41	5	M9695
Drug	PCN 67	CYP1A1 PLEC	3.16e-06	2	41	2	CID000107693
Drug	4-bromophenol	CYP1A1 SYNE1 NISCH PGR	7.61e-06	70	41	4	CID000007808
Drug	PCN 66	CYP1A1 PLEC	9.48e-06	3	41	2	CID000107698
Drug	Pempidine tartrate [546-48-5]; Down 200; 13uM; MCF7; HT_HG-U133A	SLC47A1 TTC28 PCM1 CEP290 B4GALT4	2.31e-05	191	41	5	3926_DN
Drug	(-)-Isoproterenol hydrochloride [5984-95-2]; Up 200; 16.2uM; MCF7; HT_HG-U133A	PLEC CHERP FUT2 CLCN6 PGR	2.62e-05	196	41	5	3571_UP
Drug	Zardaverine [101975-10-4]; Down 200; 15uM; MCF7; HT_HG-U133A	CYP1A1 CHD3 PLEC TTC28 PCM1	2.68e-05	197	41	5	7347_DN
Drug	Lymecycline [992-21-2]; Up 200; 6.6uM; MCF7; HT_HG-U133A	PLEC FUT2 CLCN6 FBXO21 PGR	2.68e-05	197	41	5	3514_UP
Drug	Nitrarine dihydrochloride [20069-05-0]; Up 200; 10.6uM; PC3; HT_HG-U133A	CYP1A1 DIAPH3 ACE FBXO21 RYR3	2.68e-05	197	41	5	3683_UP
Drug	Dioxybenzone [131-53-3]; Down 200; 16.4uM; MCF7; HT_HG-U133A	CYP1A1 CLCN6 FBXO21 CEP290 B4GALT4	2.75e-05	198	41	5	6478_DN
Drug	6-hydroxychrysene	CYP1A1 PGR	3.15e-05	5	41	2	ctd:C087203
Drug	6-NCDF	CYP1A1 PGR	4.72e-05	6	41	2	CID000130492
Drug	Etoc	PLEC PGR	4.72e-05	6	41	2	CID000031621
Drug	T 47	ACE PGR	6.61e-05	7	41	2	CID000134566
Drug	RU 58668	CYP1A1 PGR	6.61e-05	7	41	2	ctd:C086511
Drug	1,2,7,8-tetrachlorodibenzofuran	CYP1A1 PGR	6.61e-05	7	41	2	CID000042844
Drug	7 alpha, 17 alpha-dimethyl-19-nortestosterone	MAP4K4 SYNE1 PGR	6.82e-05	44	41	3	CID000019454
Drug	Halowax	CYP1A1 PLEC	8.80e-05	8	41	2	CID000007056
Drug	N-Acetyl-D-glucosamine	B4GALT4 B4GALT3	8.80e-05	8	41	2	DB00141
Drug	thiobenzoic acid	ACE SYNE1	8.80e-05	8	41	2	CID000007414
Disease	autosomal recessive polycystic kidney disease (implicated_via_orthology)	TSC1 ACE	1.92e-04	16	38	2	DOID:0110861 (implicated_via_orthology)
Disease	pneumonia (is_implicated_in)	CYP1A1 ACE	1.92e-04	16	38	2	DOID:552 (is_implicated_in)
Disease	ankylosing spondylitis (is_implicated_in)	CYP1A1 ACE	2.72e-04	19	38	2	DOID:7147 (is_implicated_in)
Disease	Weight Gain	HDHD2 ACE FBXO21	3.10e-04	102	38	3	C0043094
Disease	Lung Injury	CYP1A1 NTRK1	3.34e-04	21	38	2	C0273115
Disease	Chronic Lung Injury	CYP1A1 NTRK1	3.34e-04	21	38	2	C2350344
Disease	psoriasis	GMNC TSC1 FUT2 CLCN6	4.13e-04	273	38	4	EFO_0000676
Disease	Depressive Symptoms	CYP1A1 ACE	5.15e-04	26	38	2	C0086132
Disease	Bradycardia	CYP1A1 NISCH	5.15e-04	26	38	2	C0428977
Disease	velopharyngeal dysfunction	TTC28 ZNF532 MFHAS1	5.23e-04	122	38	3	EFO_0009336
Disease	corpus callosum mid-anterior volume measurement	GMNC PLEC	5.55e-04	27	38	2	EFO_0010297
Disease	corpus callosum central volume measurement	GMNC PLEC	5.98e-04	28	38	2	EFO_0010296
Disease	Behcet's disease (is_implicated_in)	CYP1A1 ACE	9.90e-04	36	38	2	DOID:13241 (is_implicated_in)
Disease	left ventricular ejection fraction measurement	PLEC MFHAS1	1.22e-03	40	38	2	EFO_0008373
Disease	end stage renal disease (is_implicated_in)	CYP1A1 ACE	1.28e-03	41	38	2	DOID:783 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLYHLHPFLQRQQLA	B4GALT3	141	O60512
EHLYQQLEPLYLNLH	ACE	241	P12821
LEHLHPFLQRQQLDY	B4GALT4	141	O60513
LLRRLYHNDHIQIAN	CT47B1	131	P0C2W7
LQHLLLIRNDYFIRQ	DIAPH3	441	Q9NSV4
LDHDLEAQLIYRHLL	RASA4	721	O43374
LDHDLEAQLIYRHLL	RASA4B	721	C9J798
RYDHNHQELLSLVNL	CYP1A1	206	P04798
NLLRFIQEVHAHYLH	PTPN23	1366	Q9H3S7
DQVQLLLLQARLYFH	FBXO21	421	O94952
QEQAYLLSLQHDHRR	MAP4K4	516	O95819
LYIENQQHLQHLELR	NTRK1	71	P04629
LNHLLERLHQSFFLY	GPAA1	346	O43292
RKAHFQYLLNHRLQI	MFHAS1	606	Q9Y4C4
HFHYQILNQAFRLLL	HDHD2	121	Q9H0R4
HFLIELFHELQLLNT	PCM1	1401	Q15154
HAFLYIRQLAIHLRN	NOC2L	376	Q9Y3T9
LLDNLHDLVKQLHLY	PGR	876	P06401
LISLEHLYIHFNQLE	PXDNL	121	A1KZ92
HNLTYEFLQARLRQH	CLCN6	851	P51797
AHFELRLHLIYLIND	CHERP	206	Q8IWX8
EDLHLQNRYLQEKLH	CEP290	2016	O15078
LLRHHYEQQQEDLAR	CHD3	1321	Q12873
FYHHLRQEILQEFTL	FUT2	156	Q10981
YFHLQQQHLIELIRQ	GID8	101	Q9NWU2
ALHLRRYNDALLIHD	DHX58	281	Q96C10
NLEHLHLENNYIKIR	ECM2	661	O94769
LLLYRELHNQLFEHQ	ERCC6L	86	Q2NKX8
LRHRCQLLQQHEEYQ	HSPBP1	321	Q9NZL4
NYQHLLEQQRAHELF	SYNE1	7486	Q8NF91
LARLHEENNHLRQYL	GMNC	101	A6NCL1
FLNYRNLHHFPLELL	LRRC28	21	Q86X40
ILQDQEHIFAHRIYL	RHOBTB1	271	O94844
LVNALANYLFLHQLH	SLC47A1	196	Q96FL8
LQTLLYRHFDQHIEN	ZNF532	916	Q9HCE3
LRDQLLLLHNQLLYE	TSC1	691	Q92574
TLFHYHQILARLQAL	TMEM143	111	Q96AN5
HTLQEHNLANYLFFL	RYR3	4811	Q15413
DNLQHLYNLVHLDLS	NISCH	326	Q9Y2I1
QALHSLELHYQAFLR	PLEC	1061	Q15149
HYQNHLNIARELRDI	TTC28	576	Q96AY4
YILDNNHTHLLLVDN	TRPM8	251	Q7Z2W7