Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	SH3 domain binding	ADAM10 SYNJ2 DENND1A ERRFI1	1.37e-05	143	21	4	GO:0017124
GeneOntologyMolecularFunction	protein domain specific binding	ADAM10 SYNJ2 DENND1A TNK2 PIK3R1 SH3PXD2B ERRFI1	2.05e-05	875	21	7	GO:0019904
GeneOntologyMolecularFunction	histone H3K4 monomethyltransferase activity	SETD1A KMT2B	2.94e-05	8	21	2	GO:0140945
GeneOntologyMolecularFunction	phosphatidylinositol 3-kinase activator activity	PIK3R1 AGAP2	3.78e-05	9	21	2	GO:0141038
GeneOntologyMolecularFunction	histone H3K4 trimethyltransferase activity	SETD1A KMT2B	4.72e-05	10	21	2	GO:0140999
GeneOntologyMolecularFunction	GTPase regulator activity	DENND1A TNK2 AGAP2 ERRFI1 SOS2	1.50e-04	507	21	5	GO:0030695
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	DENND1A TNK2 AGAP2 ERRFI1 SOS2	1.50e-04	507	21	5	GO:0060589
GeneOntologyMolecularFunction	phosphatidylinositol 3-kinase regulator activity	PIK3R1 AGAP2	1.60e-04	18	21	2	GO:0035014
GeneOntologyMolecularFunction	histone H3K4 methyltransferase activity	SETD1A KMT2B	1.98e-04	20	21	2	GO:0042800
GeneOntologyMolecularFunction	enzyme regulator activity	DENND1A TNK2 PIK3R1 SH3PXD2B AGAP2 ERRFI1 SOS2	4.30e-04	1418	21	7	GO:0030234
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	TNK2 PIK3R1 TGFBR3L HUNK TEC	7.05e-04	709	21	5	GO:0016773
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	SETD1A KMT2B	9.70e-04	44	21	2	GO:0140938
GeneOntologyMolecularFunction	kinase activity	TNK2 PIK3R1 TGFBR3L HUNK TEC	9.88e-04	764	21	5	GO:0016301
GeneOntologyMolecularFunction	non-membrane spanning protein tyrosine kinase activity	TNK2 TEC	1.06e-03	46	21	2	GO:0004715
GeneOntologyMolecularFunction	phosphatidylinositol-3-phosphate binding	DENND1A SH3PXD2B	1.15e-03	48	21	2	GO:0032266
GeneOntologyMolecularFunction	SH2 domain binding	ADAM10 SH3PXD2B	1.35e-03	52	21	2	GO:0042169
GeneOntologyMolecularFunction	protein-lysine N-methyltransferase activity	SETD1A KMT2B	2.30e-03	68	21	2	GO:0016279
GeneOntologyMolecularFunction	lysine N-methyltransferase activity	SETD1A KMT2B	2.37e-03	69	21	2	GO:0016278
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	TNK2 PIK3R1 TGFBR3L HUNK TEC	2.45e-03	938	21	5	GO:0016772
GeneOntologyMolecularFunction	histone methyltransferase activity	SETD1A KMT2B	2.51e-03	71	21	2	GO:0042054
GeneOntologyMolecularFunction	protein kinase activity	TNK2 TGFBR3L HUNK TEC	3.21e-03	600	21	4	GO:0004672
GeneOntologyMolecularFunction	enzyme activator activity	PIK3R1 SH3PXD2B AGAP2 ERRFI1	4.42e-03	656	21	4	GO:0008047
GeneOntologyMolecularFunction	protein methyltransferase activity	SETD1A KMT2B	5.19e-03	103	21	2	GO:0008276
GeneOntologyMolecularFunction	N-methyltransferase activity	SETD1A KMT2B	5.39e-03	105	21	2	GO:0008170
GeneOntologyMolecularFunction	molecular function activator activity	CACNA1S PIK3R1 SH3PXD2B AGAP2 ERRFI1	7.89e-03	1233	21	5	GO:0140677
GeneOntologyMolecularFunction	protein tyrosine kinase activity	TNK2 TEC	1.00e-02	145	21	2	GO:0004713
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	TNK2 TGFBR3L HUNK	1.09e-02	446	21	3	GO:0004674
GeneOntologyMolecularFunction	protein kinase binding	ADAM10 PIK3R1 AGAP2 ERRFI1	1.20e-02	873	21	4	GO:0019901
GeneOntologyMolecularFunction	kinase activator activity	PIK3R1 AGAP2	1.20e-02	159	21	2	GO:0019209
GeneOntologyMolecularFunction	S-adenosylmethionine-dependent methyltransferase activity	SETD1A KMT2B	1.39e-02	172	21	2	GO:0008757
GeneOntologyMolecularFunction	growth factor receptor binding	TNK2 PIK3R1	1.41e-02	173	21	2	GO:0070851
GeneOntologyBiologicalProcess	positive regulation of mammary gland epithelial cell proliferation	AGAP2 RREB1	3.54e-05	9	21	2	GO:0033601
GeneOntologyBiologicalProcess	striated muscle adaptation	TNNT1 CACNA1S ERRFI1	5.40e-05	73	21	3	GO:0014888
GeneOntologyBiologicalProcess	actin cytoskeleton organization	TNNT1 GAS2L2 PIK3R1 SH3D21 SH3PXD2B AGAP2	1.12e-04	803	21	6	GO:0030036
GeneOntologyBiologicalProcess	regulation of mammary gland epithelial cell proliferation	AGAP2 RREB1	2.05e-04	21	21	2	GO:0033599
GeneOntologyBiologicalProcess	actin filament-based process	TNNT1 GAS2L2 PIK3R1 SH3D21 SH3PXD2B AGAP2	2.25e-04	912	21	6	GO:0030029
GeneOntologyCellularComponent	perinuclear endoplasmic reticulum	ADAM10 PIK3R1	3.84e-04	29	21	2	GO:0097038
GeneOntologyCellularComponent	dendrite	ADAM10 DENND1A CACNA1S TNK2 AGAP2	1.35e-03	858	21	5	GO:0030425
GeneOntologyCellularComponent	dendritic tree	ADAM10 DENND1A CACNA1S TNK2 AGAP2	1.37e-03	860	21	5	GO:0097447
GeneOntologyCellularComponent	clathrin-coated vesicle	ADAM10 DENND1A TNK2	1.65e-03	237	21	3	GO:0030136
GeneOntologyCellularComponent	anchoring junction	ADAM10 TNK2 PIK3R1 SH3PXD2B TEC	2.39e-03	976	21	5	GO:0070161
GeneOntologyCellularComponent	histone methyltransferase complex	SETD1A KMT2B	2.55e-03	75	21	2	GO:0035097
GeneOntologyCellularComponent	cell-cell junction	ADAM10 TNK2 PIK3R1 TEC	2.58e-03	591	21	4	GO:0005911
Domain	Mig-6	TNK2 ERRFI1	1.20e-06	2	21	2	IPR021619
Domain	Cdc42_binding_dom-like	TNK2 ERRFI1	1.20e-06	2	21	2	IPR015116
Domain	GTPase_binding	TNK2 ERRFI1	1.20e-06	2	21	2	PF09027
Domain	Inhibitor_Mig-6	TNK2 ERRFI1	1.20e-06	2	21	2	PF11555
Domain	SH3	TNK2 PIK3R1 SH3D21 SH3PXD2B TEC	3.46e-06	216	21	5	PS50002
Domain	SH3	TNK2 PIK3R1 SH3D21 SH3PXD2B TEC	3.46e-06	216	21	5	SM00326
Domain	SH3_domain	TNK2 PIK3R1 SH3D21 SH3PXD2B TEC	3.78e-06	220	21	5	IPR001452
Domain	SH3_1	TNK2 PIK3R1 SH3PXD2B TEC	3.05e-05	164	21	4	PF00018
Domain	SH3_2	PIK3R1 SH3D21 SH3PXD2B	1.18e-04	86	21	3	IPR011511
Domain	SH3_2	PIK3R1 SH3D21 SH3PXD2B	1.18e-04	86	21	3	PF07653
Domain	Post-SET_dom	SETD1A KMT2B	1.43e-04	16	21	2	IPR003616
Domain	PostSET	SETD1A KMT2B	1.43e-04	16	21	2	SM00508
Domain	POST_SET	SETD1A KMT2B	1.43e-04	16	21	2	PS50868
Domain	SET	SETD1A KMT2B	9.62e-04	41	21	2	PF00856
Domain	SET	SETD1A KMT2B	1.21e-03	46	21	2	SM00317
Domain	SET_dom	SETD1A KMT2B	1.43e-03	50	21	2	IPR001214
Domain	SET	SETD1A KMT2B	1.43e-03	50	21	2	PS50280
Domain	PH	AGAP2 TEC SOS2	2.06e-03	229	21	3	PF00169
Domain	PH	AGAP2 TEC SOS2	3.56e-03	278	21	3	SM00233
Domain	PH_DOMAIN	AGAP2 TEC SOS2	3.59e-03	279	21	3	PS50003
Domain	PH_domain	AGAP2 TEC SOS2	3.63e-03	280	21	3	IPR001849
Domain	TyrKc	TNK2 TEC	4.35e-03	88	21	2	SM00219
Domain	Tyr_kinase_cat_dom	TNK2 TEC	4.35e-03	88	21	2	IPR020635
Domain	PROTEIN_KINASE_TYR	TNK2 TEC	5.26e-03	97	21	2	PS00109
Domain	Tyr_kinase_AS	TNK2 TEC	5.26e-03	97	21	2	IPR008266
Domain	SH2	PIK3R1 TEC	5.69e-03	101	21	2	PF00017
Domain	SH2	PIK3R1 TEC	6.71e-03	110	21	2	SM00252
Domain	SH2	PIK3R1 TEC	6.83e-03	111	21	2	PS50001
Domain	SH2	PIK3R1 TEC	6.95e-03	112	21	2	IPR000980
Domain	-	PIK3R1 TEC	6.95e-03	112	21	2	3.30.505.10
Domain	Protein_kinase_ATP_BS	TNK2 HUNK TEC	8.41e-03	379	21	3	IPR017441
Domain	Pkinase_Tyr	TNK2 TEC	9.12e-03	129	21	2	PF07714
Domain	-	AGAP2 TEC SOS2	9.15e-03	391	21	3	2.30.29.30
Domain	Ser-Thr/Tyr_kinase_cat_dom	TNK2 TEC	1.04e-02	138	21	2	IPR001245
Domain	PH_dom-like	AGAP2 TEC SOS2	1.15e-02	426	21	3	IPR011993
Domain	PROTEIN_KINASE_ATP	TNK2 HUNK TEC	1.41e-02	459	21	3	PS00107
Domain	Prot_kinase_dom	TNK2 HUNK TEC	1.67e-02	489	21	3	IPR000719
Domain	PROTEIN_KINASE_DOM	TNK2 HUNK TEC	1.71e-02	493	21	3	PS50011
Pathway	WP_EGFEGFR_SIGNALING	TNK2 PIK3R1 ERRFI1 SOS2	2.08e-05	162	15	4	M39334
Pathway	WP_EGFR1_SIGNALING_PATHWAY	TNK2 PIK3R1 ERRFI1 SOS2	3.73e-05	188	15	4	MM15828
Pathway	REACTOME_SIGNALING_BY_LTK	TNK2 PIK3R1	5.78e-05	11	15	2	MM17235
Pathway	WP_PROLACTIN_SIGNALING	PIK3R1 AGAP2 TEC	6.54e-05	76	15	3	M39601
Pathway	REACTOME_SIGNALING_BY_LTK	TNK2 PIK3R1	6.93e-05	12	15	2	M48256
Pathway	KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY	PIK3R1 TEC SOS2	1.86e-04	108	15	3	M9904
Pathway	REACTOME_NERVOUS_SYSTEM_DEVELOPMENT	ADAM10 CACNA1S PIK3R1 AGAP2 SOS2	2.37e-04	575	15	5	M29853
Pathway	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	PIK3R1 SOS2	3.65e-04	27	15	2	M1718
Pathway	PID_NETRIN_PATHWAY	PIK3R1 AGAP2	5.15e-04	32	15	2	M108
Pathway	PID_EPO_PATHWAY	PIK3R1 TEC	5.47e-04	33	15	2	M233
Pathway	REACTOME_INTERLEUKIN_2_FAMILY_SIGNALING	PIK3R1 SOS2	6.16e-04	35	15	2	MM15144
Pathway	PID_PI3K_PLC_TRK_PATHWAY	PIK3R1 AGAP2	6.52e-04	36	15	2	M271
Pathway	REACTOME_FORMATION_OF_WDR5_CONTAINING_HISTONE_MODIFYING_COMPLEXES	SETD1A KMT2B	7.27e-04	38	15	2	MM17073
Pathway	REACTOME_FORMATION_OF_WDR5_CONTAINING_HISTONE_MODIFYING_COMPLEXES	SETD1A KMT2B	8.88e-04	42	15	2	M48018
Pathway	REACTOME_SIGNALING_BY_SCF_KIT	PIK3R1 TEC	9.31e-04	43	15	2	M508
Pathway	REACTOME_INTERLEUKIN_2_FAMILY_SIGNALING	PIK3R1 SOS2	9.74e-04	44	15	2	M1012
Pathway	REACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION	SETD1A KMT2B	9.74e-04	44	15	2	MM15527
Pathway	REACTOME_PKMTS_METHYLATE_HISTONE_LYSINES	SETD1A KMT2B	1.06e-03	46	15	2	MM14933
Pathway	SIG_BCR_SIGNALING_PATHWAY	PIK3R1 SOS2	1.06e-03	46	15	2	M8626
Pathway	REACTOME_INTERLEUKIN_3_INTERLEUKIN_5_AND_GM_CSF_SIGNALING	PIK3R1 TEC	1.16e-03	48	15	2	M914
Pathway	WP_TROP2_REGULATORY_SIGNALING	ADAM10 PIK3R1	1.21e-03	49	15	2	M46458
Pathway	REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE	SYNJ2 PIK3R1	1.26e-03	50	15	2	MM14641
Pathway	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	PIK3R1 SOS2	1.31e-03	51	15	2	M7955
Pathway	PID_KIT_PATHWAY	PIK3R1 TEC	1.36e-03	52	15	2	M231
Pathway	KEGG_ENDOMETRIAL_CANCER	PIK3R1 SOS2	1.36e-03	52	15	2	M19877
Pathway	REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE	SYNJ2 PIK3R1	1.41e-03	53	15	2	M662
Pathway	REACTOME_SIGNALING_BY_EGFR	ADAM10 PIK3R1	1.41e-03	53	15	2	M27039
Pathway	KEGG_NON_SMALL_CELL_LUNG_CANCER	PIK3R1 SOS2	1.46e-03	54	15	2	M19818
Pathway	KEGG_ACUTE_MYELOID_LEUKEMIA	PIK3R1 SOS2	1.63e-03	57	15	2	M19888
Pathway	WP_KIT_RECEPTOR_SIGNALING	PIK3R1 TEC	1.75e-03	59	15	2	M39350
Pathway	WP_MET_IN_TYPE_1_PAPILLARY_RENAL_CELL_CARCINOMA	PIK3R1 SOS2	1.75e-03	59	15	2	M39750
Pathway	REACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES	ADAM10 TNK2 PIK3R1 TEC	1.96e-03	532	15	4	M27870
Pathway	WP_ENDOMETRIAL_CANCER	PIK3R1 SOS2	1.99e-03	63	15	2	M39623
Pathway	WP_HISTONE_MODIFICATIONS	SETD1A KMT2B	2.11e-03	65	15	2	M39374
Pathway	KEGG_GLIOMA	PIK3R1 SOS2	2.11e-03	65	15	2	M1835
Pathway	WP_ACUTE_MYELOID_LEUKEMIA	PIK3R1 SOS2	2.31e-03	68	15	2	M48322
Pathway	WP_MELANOMA	PIK3R1 SOS2	2.31e-03	68	15	2	M39811
Pathway	WP_ALZHEIMERS_DISEASE	ADAM10 CACNA1S PIK3R1	2.42e-03	261	15	3	M42565
Pathway	REACTOME_DEVELOPMENTAL_BIOLOGY	ADAM10 CACNA1S PIK3R1 HES7 AGAP2 SOS2	2.42e-03	1432	15	6	M509
Pathway	KEGG_RENAL_CELL_CARCINOMA	PIK3R1 SOS2	2.45e-03	70	15	2	M13266
Pathway	REACTOME_PKMTS_METHYLATE_HISTONE_LYSINES	SETD1A KMT2B	2.45e-03	70	15	2	M27231
Pathway	PID_CDC42_PATHWAY	TNK2 PIK3R1	2.45e-03	70	15	2	M81
Pathway	WP_KIT_RECEPTOR_SIGNALING_PATHWAY	PIK3R1 TEC	2.52e-03	71	15	2	MM15947
Pathway	WP_NONSMALL_CELL_LUNG_CANCER	PIK3R1 SOS2	2.59e-03	72	15	2	M39738
Pathway	KEGG_CHRONIC_MYELOID_LEUKEMIA	PIK3R1 SOS2	2.66e-03	73	15	2	M321
Pathway	WP_ALZHEIMERS_DISEASE	ADAM10 CACNA1S	2.73e-03	74	15	2	MM15962
Pathway	KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY	PIK3R1 SOS2	2.80e-03	75	15	2	M5436
Pathway	KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	SYNJ2 PIK3R1	2.88e-03	76	15	2	M9052
Pathway	REACTOME_PI_METABOLISM	SYNJ2 PIK3R1	2.95e-03	77	15	2	MM14590
Pathway	KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY	PIK3R1 SOS2	3.11e-03	79	15	2	M11816
Pathway	WP_DELTANOTCH_SIGNALING_PATHWAY	ADAM10 PIK3R1	3.34e-03	82	15	2	MM15922
Pathway	WP_GLIOBLASTOMA_SIGNALING	PIK3R1 ERRFI1	3.42e-03	83	15	2	M39637
Pathway	REACTOME_PI_METABOLISM	SYNJ2 PIK3R1	3.50e-03	84	15	2	M676
Pathway	WP_EGFR_TYROSINE_KINASE_INHIBITOR_RESISTANCE	PIK3R1 SOS2	3.50e-03	84	15	2	M39839
Pathway	KEGG_ERBB_SIGNALING_PATHWAY	PIK3R1 SOS2	3.75e-03	87	15	2	M12467
Pathway	KEGG_PROSTATE_CANCER	PIK3R1 SOS2	3.92e-03	89	15	2	M13191
Pathway	KEGG_MEDICUS_REFERENCE_GF_RTK_RAS_PI3K_SIGNALING_PATHWAY	PIK3R1 SOS2	3.92e-03	89	15	2	M47963
Pubmed	Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.	PIK3R1 SH3PXD2B HUNK TEC ERRFI1 SOS2	4.18e-11	103	22	6	21706016
Pubmed	Epidermal growth factor receptor phosphorylation sites Ser991 and Tyr998 are implicated in the regulation of receptor endocytosis and phosphorylations at Ser1039 and Thr1041.	PIK3R1 ERRFI1 SOS2	1.78e-07	18	22	3	19531499
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	CACNA1S SETD1A TNK2 PIK3R1 SH3D21 SOS2	2.18e-07	430	22	6	35044719
Pubmed	Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N.	PIK3R1 AGAP2	1.15e-06	3	22	2	11136977
Pubmed	Tandem immunoprecipitation of phosphotyrosine-mass spectrometry (TIPY-MS) indicates C19ORF19 becomes tyrosine-phosphorylated and associated with activated epidermal growth factor receptor.	TNK2 ERRFI1 SOS2	1.18e-06	33	22	3	18271526
Pubmed	Activity of the nonreceptor tyrosine kinase Ack1 is regulated by tyrosine phosphorylation of its Mig6 homology region.	TNK2 ERRFI1	2.29e-06	4	22	2	36178070
Pubmed	Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation.	SETD1A KMT2B	3.82e-06	5	22	2	25561738
Pubmed	Assembly of nuclear dimers of PI3K regulatory subunits is regulated by the Cdc42-activated tyrosine kinase ACK.	TNK2 PIK3R1	3.82e-06	5	22	2	35429500
Pubmed	Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.	PIK3R1 SH3PXD2B TEC	4.22e-06	50	22	3	19807924
Pubmed	GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28.	PIK3R1 SOS2	8.01e-06	7	22	2	10820259
Pubmed	Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling.	TNK2 ERRFI1	8.01e-06	7	22	2	19815557
Pubmed	Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK.	PIK3R1 TEC	8.01e-06	7	22	2	9178903
Pubmed	Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.	SETD1A KMT2B	1.07e-05	8	22	2	23130995
Pubmed	The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.	SETD1A KMT2B	1.07e-05	8	22	2	22266653
Pubmed	A human MAP kinase interactome.	SYNJ2 TNK2 PIK3R1 ERRFI1 SOS2	1.13e-05	486	22	5	20936779
Pubmed	Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.	SETD1A KMT2B	1.37e-05	9	22	2	22665483
Pubmed	Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS.	SETD1A KMT2B	1.71e-05	10	22	2	18838538
Pubmed	The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization.	PIK3R1 TEC SOS2	1.82e-05	81	22	3	20697350
Pubmed	Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.	SETD1A KMT2B	2.51e-05	12	22	2	27563068
Pubmed	PTPRA Phosphatase Regulates GDNF-Dependent RET Signaling and Inhibits the RET Mutant MEN2A Oncogenic Potential.	ADAM10 PIK3R1 SOS2	2.84e-05	94	22	3	32062451
Pubmed	Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.	SETD1A KMT2B	2.97e-05	13	22	2	24619213
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	SYNJ2 SETD1A KMT2B	3.84e-05	104	22	3	9205841
Pubmed	SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53.	SETD1A KMT2B	4.56e-05	16	22	2	23870121
Pubmed	Genome-wide association of body fat distribution in African ancestry populations suggests new loci.	DENND1A RREB1	4.56e-05	16	22	2	23966867
Pubmed	Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells.	PIK3R1 TEC	4.56e-05	16	22	2	11071635
Pubmed	H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.	SETD1A KMT2B	4.56e-05	16	22	2	24368734
Pubmed	Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.	SYNJ2 PIK3R1 SOS2	4.66e-05	111	22	3	22558309
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	SYNJ2 PIK3R1 KMT2B SOS2	5.03e-05	329	22	4	17474147
Pubmed	PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.	SETD1A KMT2B	5.81e-05	18	22	2	17500065
Pubmed	Targeting of EGFR by a combination of antibodies mediates unconventional EGFR trafficking and degradation.	PIK3R1 SOS2	6.49e-05	19	22	2	31959764
Pubmed	Structural basis for activity regulation of MLL family methyltransferases.	SETD1A KMT2B	8.76e-05	22	22	2	26886794
Pubmed	EG-1 interacts with c-Src and activates its signaling pathway.	PIK3R1 TEC	8.76e-05	22	22	2	16964398
Pubmed	Identification and characterization of a novel human PP1 phosphatase complex.	SETD1A KMT2B	1.76e-04	31	22	2	20516061
Pubmed	Bioinformatics and cellular signaling.	PIK3R1 ERRFI1 SOS2	2.02e-04	182	22	3	15102471
Pubmed	Impact of WIN site inhibitor on the WDR5 interactome.	SETD1A KMT2B	3.40e-04	43	22	2	33472061
Pubmed	The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.	PIK3R1 TEC	3.89e-04	46	22	2	23793062
Pubmed	Large-scale structural analysis of the classical human protein tyrosine phosphatome.	TNK2 TEC	4.06e-04	47	22	2	19167335
Pubmed	Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.	SETD1A KMT2B	4.41e-04	49	22	2	34368113
Pubmed	Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.	SETD1A KMT2B	4.59e-04	50	22	2	37974198
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DENND1A SETD1A TNK2 SH3PXD2B KMT2B	5.38e-04	1105	22	5	35748872
Pubmed	New nomenclature for chromatin-modifying enzymes.	SETD1A KMT2B	5.97e-04	57	22	2	18022353
Pubmed	Charting the molecular network of the drug target Bcr-Abl.	PIK3R1 TEC SOS2	6.12e-04	266	22	3	19380743
Interaction	MAP6 interactions	ADAM10 TNK2 PIK3R1 AGAP2	2.49e-08	32	20	4	int:MAP6
Interaction	GRB2 interactions	ADAM10 SYNJ2 TNK2 PIK3R1 SH3PXD2B HUNK TEC ERRFI1 SOS2	2.83e-08	806	20	9	int:GRB2
Interaction	NCK1 interactions	SYNJ2 TNK2 PIK3R1 SH3PXD2B SOS2	3.34e-06	244	20	5	int:NCK1
Interaction	PLCG1 interactions	PIK3R1 AGAP2 TEC ERRFI1 SOS2	4.90e-06	264	20	5	int:PLCG1
Interaction	MTCL3 interactions	ADAM10 TNK2 RREB1	7.47e-06	39	20	3	int:MTCL3
Interaction	SRCIN1 interactions	ADAM10 TNK2 AGAP2	8.07e-06	40	20	3	int:SRCIN1
Interaction	SNX9 interactions	TNK2 PIK3R1 TEC SOS2	1.30e-05	150	20	4	int:SNX9
Interaction	AXL interactions	ADAM10 TNK2 PIK3R1 TEC ERRFI1	2.48e-05	369	20	5	int:AXL
Interaction	PIK3R3 interactions	TNK2 PIK3R1 KMT2B TEC	3.87e-05	198	20	4	int:PIK3R3
Interaction	IQSEC3 interactions	ADAM10 AGAP2	8.45e-05	14	20	2	int:IQSEC3
Interaction	WAS interactions	TNK2 PIK3R1 TEC	8.99e-05	89	20	3	int:WAS
Interaction	KAT8 interactions	SETD1A TNK2 KMT2B	1.09e-04	95	20	3	int:KAT8
Interaction	ANK2 interactions	ADAM10 TNK2 AGAP2	1.20e-04	98	20	3	int:ANK2
Interaction	NLGN3 interactions	TNK2 PIK3R1 AGAP2	1.23e-04	99	20	3	int:NLGN3
Interaction	PRMT8 interactions	ADAM10 PIK3R1 AGAP2	1.43e-04	104	20	3	int:PRMT8
Interaction	FASLG interactions	PIK3R1 SH3PXD2B TEC	1.47e-04	105	20	3	int:FASLG
Interaction	PTK2B interactions	TNK2 PIK3R1 AGAP2	2.13e-04	119	20	3	int:PTK2B
Interaction	ELK3 interactions	SETD1A KMT2B RREB1	2.18e-04	120	20	3	int:ELK3
Interaction	SORBS1 interactions	TNK2 AGAP2 HUNK	2.34e-04	123	20	3	int:SORBS1
Interaction	DCLK1 interactions	DENND1A TNK2 AGAP2	2.58e-04	127	20	3	int:DCLK1
Interaction	BIN1 interactions	TNK2 HUNK SOS2	2.70e-04	129	20	3	int:BIN1
Interaction	RIMS2 interactions	CACNA1S AGAP2	3.24e-04	27	20	2	int:RIMS2
Interaction	CLTA interactions	SYNJ2 DENND1A TNK2 PIK3R1	3.51e-04	351	20	4	int:CLTA
Interaction	SHC1 interactions	PIK3R1 TEC ERRFI1 SOS2	3.95e-04	362	20	4	int:SHC1
Interaction	ITFG2 interactions	TNK2 SH3PXD2B	4.00e-04	30	20	2	int:ITFG2
Interaction	RASGRF1 interactions	TNK2 SOS2	4.28e-04	31	20	2	int:RASGRF1
Interaction	PRLR interactions	AGAP2 TEC	4.28e-04	31	20	2	int:PRLR
Interaction	LTK interactions	TNK2 PIK3R1 ERRFI1	4.36e-04	152	20	3	int:LTK
Interaction	KDM6A interactions	SETD1A HUNK KMT2B	5.26e-04	162	20	3	int:KDM6A
Interaction	PPFIA2 interactions	ADAM10 AGAP2	6.10e-04	37	20	2	int:PPFIA2
Interaction	PIK3R1 interactions	TNK2 PIK3R1 AGAP2 TEC	6.43e-04	412	20	4	int:PIK3R1
Interaction	NRCAM interactions	ADAM10 AGAP2	7.50e-04	41	20	2	int:NRCAM
Interaction	ANXA7 interactions	ADAM10 HUNK KMT2B	7.61e-04	184	20	3	int:ANXA7
Interaction	FYN interactions	TNNT1 TNK2 PIK3R1 ERRFI1	7.62e-04	431	20	4	int:FYN
Interaction	DLGAP3 interactions	TNK2 AGAP2	8.63e-04	44	20	2	int:DLGAP3
Interaction	KLF12 interactions	SETD1A KMT2B RREB1	8.87e-04	194	20	3	int:KLF12
Interaction	NAPA interactions	ADAM10 HUNK RREB1	9.01e-04	195	20	3	int:NAPA
Interaction	FEV interactions	SETD1A KMT2B RREB1	1.01e-03	203	20	3	int:FEV
Interaction	SOCS7 interactions	GAS2L2 PIK3R1	1.07e-03	49	20	2	int:SOCS7
Interaction	RAPGEF4 interactions	ADAM10 AGAP2	1.11e-03	50	20	2	int:RAPGEF4
Interaction	CD2AP interactions	PIK3R1 SH3D21 SOS2	1.18e-03	214	20	3	int:CD2AP
Interaction	PPFIA1 interactions	TNNT1 PIK3R1 AGAP2	1.18e-03	214	20	3	int:PPFIA1
Interaction	NCKAP1 interactions	ADAM10 PIK3R1 AGAP2	1.24e-03	218	20	3	int:NCKAP1
Interaction	PHF20 interactions	SETD1A KMT2B	1.25e-03	53	20	2	int:PHF20
Interaction	CAMK2D interactions	ADAM10 SETD1A AGAP2	1.31e-03	222	20	3	int:CAMK2D
Interaction	LCP2 interactions	TNK2 PIK3R1	1.35e-03	55	20	2	int:LCP2
Interaction	NFIX interactions	SETD1A KMT2B RREB1	1.40e-03	227	20	3	int:NFIX
Interaction	CRKL interactions	TNK2 PIK3R1 SOS2	1.40e-03	227	20	3	int:CRKL
Interaction	PDGFRB interactions	TNK2 PIK3R1 ERRFI1	1.41e-03	228	20	3	int:PDGFRB
Interaction	KLF3 interactions	SETD1A KMT2B RREB1	1.41e-03	228	20	3	int:KLF3
Interaction	WASF3 interactions	ADAM10 PIK3R1	1.45e-03	57	20	2	int:WASF3
Interaction	TXK interactions	PIK3R1 TEC	1.45e-03	57	20	2	int:TXK
Interaction	MAPRE3 interactions	GAS2L2 SYNJ2 SH3PXD2B	1.45e-03	230	20	3	int:MAPRE3
Interaction	LRRC7 interactions	TNK2 AGAP2	1.50e-03	58	20	2	int:LRRC7
Interaction	DOK1 interactions	PIK3R1 TEC	1.55e-03	59	20	2	int:DOK1
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	SETD1A KMT2B	2.64e-04	34	13	2	487
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	AGAP2 TEC SOS2	3.83e-04	206	13	3	682
GeneFamily	SH2 domain containing	PIK3R1 TEC	2.32e-03	101	13	2	741
Drug	0316684-0000 [391209-55-5]; Down 200; 10uM; MCF7; HT_HG-U133A	ADAM10 TNK2 PIK3R1 SOS2	2.18e-05	193	20	4	7052_DN
Drug	Parbendazole [14255-87-9]; Down 200; 16.2uM; PC3; HT_HG-U133A	ADAM10 SYNJ2 PIK3R1 SOS2	2.18e-05	193	20	4	3799_DN
Drug	Flutamide [13311-84-7]; Down 200; 14.4uM; MCF7; HT_HG-U133A	SYNJ2 PIK3R1 AGAP2 SOS2	2.23e-05	194	20	4	4361_DN
Drug	Epiandrosterone [481-29-8]; Down 200; 13.8uM; HL60; HT_HG-U133A	SYNJ2 SETD1A TNK2 SOS2	2.27e-05	195	20	4	2444_DN
Drug	Lomefloxacin hydrochloride [98079-52-8]; Down 200; 10.4uM; HL60; HT_HG-U133A	ADAM10 SETD1A TNK2 PIK3R1	2.41e-05	198	20	4	2348_DN
Drug	Eucatropine hydrochloride [536-93-6]; Down 200; 12.2uM; PC3; HT_HG-U133A	ADAM10 SYNJ2 SETD1A SOS2	2.46e-05	199	20	4	3759_DN
Drug	Chenodiol [474-25-9]; Down 200; 10.2uM; MCF7; HT_HG-U133A	SYNJ2 TNK2 KMT2B SOS2	2.46e-05	199	20	4	7433_DN
Drug	nordihydroguaiaretic acid; Up 200; 1uM; HL60; HT_HG-U133A	SYNJ2 SETD1A SH3D21 SOS2	2.51e-05	200	20	4	1164_UP
Drug	di-n-butyl sebacate	TNNT1 TEC	3.28e-05	10	20	2	CID000007986
Drug	2,3,7,8-tetrabromodibenzo-p-dioxin	AGAP2 TEC	1.52e-04	21	20	2	CID000039729
Drug	p-diphenol oxidase	TNNT1 HUNK	3.14e-04	30	20	2	CID003013170
Drug	veratryl alcohol	TNNT1 HUNK	3.36e-04	31	20	2	CID000007118
Drug	lavendustin A	CACNA1S PIK3R1 TEC	4.32e-04	171	20	3	CID000003894
Drug	Ethaverine hydrochloride [985-13-7]; Down 200; 9.2uM; HL60; HT_HG-U133A	TNNT1 TEC SOS2	4.54e-04	174	20	3	3037_DN
Drug	Ritodrine hydrochloride [23239-51-2]; Up 200; 12.4uM; PC3; HT_HG-U133A	SETD1A AGAP2 SOS2	4.94e-04	179	20	3	4619_UP
Drug	Camptothecine (S,+) [7689-03-4]; Down 200; 11.4uM; MCF7; HT_HG-U133A	PIK3R1 SOS2 RREB1	5.18e-04	182	20	3	3887_DN
Drug	0179445-0000 [211246-22-9]; Down 200; 10uM; MCF7; HT_HG-U133A	SYNJ2 PIK3R1 RREB1	5.18e-04	182	20	3	3630_DN
Drug	radicicol, diheterospora chlamydosporia; Up 200; 0.1uM; HL60; HT_HG-U133A	TNNT1 TEC SOS2	5.18e-04	182	20	3	1160_UP
Drug	Camptothecine (S,+) [7689-03-4]; Down 200; 11.4uM; MCF7; HT_HG-U133A	PIK3R1 SOS2 RREB1	5.35e-04	184	20	3	2321_DN
Drug	17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A_EA	SYNJ2 PIK3R1 KMT2B	5.52e-04	186	20	3	831_DN
Drug	15d-PGJ2; Down 200; 10uM; MCF7; HT_HG-U133A	ADAM10 PIK3R1 KMT2B	5.61e-04	187	20	3	6948_DN
Drug	myo-inositol	SYNJ2 CACNA1S PIK3R1 AGAP2 TEC	5.62e-04	811	20	5	CID000000892
Drug	Picrotoxinin [17617-45-7]; Down 200; 13.6uM; HL60; HT_HG-U133A	ADAM10 TEC SOS2	5.70e-04	188	20	3	2161_DN
Drug	Piracetam [7491-74-9]; Down 200; 28.2uM; MCF7; HT_HG-U133A	SYNJ2 PIK3R1 SOS2	5.96e-04	191	20	3	2861_DN
Drug	Methapyrilene hydrochloride [135-23-9]; Down 200; 13.4uM; PC3; HT_HG-U133A	SYNJ2 PIK3R1 SOS2	5.96e-04	191	20	3	6644_DN
Drug	17-DMAG; Down 200; 0.1uM; PC3; HT_HG-U133A	ADAM10 PIK3R1 SOS2	5.96e-04	191	20	3	4437_DN
Drug	Norgestrel-(-)-D [797-63-7]; Down 200; 12.8uM; PC3; HT_HG-U133A	SYNJ2 PIK3R1 SOS2	5.96e-04	191	20	3	4269_DN
Drug	Cinoxacin [28657-80-9]; Down 200; 15.2uM; HL60; HT_HG-U133A	ADAM10 SETD1A SOS2	6.05e-04	192	20	3	2722_DN
Drug	Acetohexamide [968-81-0]; Up 200; 12.4uM; PC3; HT_HG-U133A	SETD1A PIK3R1 KMT2B	6.05e-04	192	20	3	1829_UP
Drug	Estropipate [7280-37-7]; Down 200; 9.2uM; MCF7; HT_HG-U133A	SYNJ2 TNK2 SOS2	6.05e-04	192	20	3	6808_DN
Drug	Naltrexone hydrochloride dihydrate [16676-29-2]; Up 200; 9.6uM; MCF7; HT_HG-U133A	PIK3R1 AGAP2 SOS2	6.15e-04	193	20	3	2209_UP
Drug	geldanamycin; Down 200; 1uM; PC3; HT_HG-U133A	PIK3R1 KMT2B SOS2	6.15e-04	193	20	3	1228_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; HL60; HT_HG-U133A	SETD1A TNK2 SOS2	6.15e-04	193	20	3	3077_DN
Drug	AC1OAGKW	SYNJ2 PIK3R1 TEC	6.15e-04	193	20	3	CID006857413
Drug	retinoic acid; Down 200; 1uM; MCF7; HT_HG-U133A	TNNT1 PIK3R1 KMT2B	6.15e-04	193	20	3	6931_DN
Drug	AC1L9MBG	TNNT1 TEC	6.18e-04	42	20	2	CID000448761
Drug	5,10CH=THF	PIK3R1 AGAP2	6.18e-04	42	20	2	CID000000136
Drug	Acetaminophen [103-90-2]; Down 200; 26.4uM; MCF7; HT_HG-U133A	SYNJ2 KMT2B SOS2	6.24e-04	194	20	3	5384_DN
Drug	Cinchonine [118-10-5]; Down 200; 13.6uM; PC3; HT_HG-U133A	SYNJ2 SH3D21 SOS2	6.24e-04	194	20	3	3988_DN
Drug	Nifedipine [21829-25-4]; Up 200; 11.6uM; PC3; HT_HG-U133A	ADAM10 KMT2B SOS2	6.24e-04	194	20	3	1814_UP
Drug	Hesperidin [520-26-3]; Up 200; 6.6uM; HL60; HT_HG-U133A	ADAM10 SYNJ2 SOS2	6.24e-04	194	20	3	1294_UP
Drug	Mefexamide hydrochloride [3413-64-7]; Down 200; 12.6uM; MCF7; HT_HG-U133A	SYNJ2 SETD1A SOS2	6.24e-04	194	20	3	2284_DN
Drug	Hydrocortisone base [50-23-7]; Up 200; 11uM; MCF7; HT_HG-U133A	TNK2 KMT2B SOS2	6.24e-04	194	20	3	3284_UP
Drug	Etifenin [63245-28-3]; Up 200; 12.4uM; MCF7; HT_HG-U133A	TNK2 SH3D21 AGAP2	6.24e-04	194	20	3	2838_UP
Drug	H-7 dihydrochloride; Up 200; 100uM; MCF7; HT_HG-U133A	ADAM10 SYNJ2 AGAP2	6.24e-04	194	20	3	5936_UP
Drug	Raloxifene hydrochloride [82640-04-8]; Up 200; 7.8uM; MCF7; HT_HG-U133A	SYNJ2 SETD1A SOS2	6.33e-04	195	20	3	6235_UP
Drug	CP-690334-01 [459212-38-5]; Down 200; 1uM; MCF7; HT_HG-U133A	ADAM10 SYNJ2 SOS2	6.33e-04	195	20	3	3909_DN
Drug	Lithocholic acid [434-13-9]; Down 200; 10.6uM; MCF7; HT_HG-U133A	TNK2 AGAP2 SOS2	6.33e-04	195	20	3	4373_DN
Drug	Fursultiamine Hydrochloride [2105-43-3]; Down 200; 9.2uM; HL60; HT_HG-U133A	ADAM10 KMT2B SOS2	6.33e-04	195	20	3	2929_DN
Drug	PF-00539745-00 [351321-33-0]; Down 200; 10uM; PC3; HT_HG-U133A	SETD1A TNK2 SOS2	6.33e-04	195	20	3	5979_DN
Drug	5194442; Up 200; 20uM; MCF7; HT_HG-U133A	SETD1A AGAP2 SOS2	6.33e-04	195	20	3	6558_UP
Drug	Papaverine hydrochloride [61-25-6]; Up 200; 10.6uM; MCF7; HT_HG-U133A	SETD1A TNK2 SOS2	6.33e-04	195	20	3	6245_UP
Drug	Evoxine [522-11-2]; Down 200; 11.6uM; HL60; HT_HG-U133A	SETD1A TNK2 SOS2	6.43e-04	196	20	3	2186_DN
Drug	estradiol, USP; Down 200; 0.01uM; HL60; HT_HG-U133A	PIK3R1 TEC SOS2	6.43e-04	196	20	3	1182_DN
Drug	Flumethasone [2135-17-3]; Down 200; 9.8uM; HL60; HT_HG-U133A	TNNT1 ADAM10 SYNJ2	6.43e-04	196	20	3	2551_DN
Drug	Pantothenic acid calcium salt monohydrate [63409-48-3]; Up 200; 8uM; HL60; HT_HG-U133A	TNNT1 SETD1A AGAP2	6.43e-04	196	20	3	1311_UP
Drug	GSK-3beta Inhibitor VIII; Up 200; 10uM; MCF7; HT_HG-U133A	SYNJ2 PIK3R1 KMT2B	6.43e-04	196	20	3	7092_UP
Drug	Strophanthidin [66-28-4]; Up 200; 9.8uM; MCF7; HT_HG-U133A	SYNJ2 KMT2B SOS2	6.43e-04	196	20	3	7182_UP
Drug	Sulfamethoxypyridazine [80-35-3]; Up 200; 14.2uM; MCF7; HT_HG-U133A	SETD1A SH3D21 KMT2B	6.43e-04	196	20	3	3409_UP
Drug	estradiol; Up 200; 0.01uM; PC3; HT_HG-U133A	ADAM10 TNK2 SOS2	6.43e-04	196	20	3	5910_UP
Drug	Debrisoquin sulfate [581-88-4]; Up 200; 9uM; MCF7; HT_HG-U133A	SYNJ2 AGAP2 KMT2B	6.43e-04	196	20	3	5288_UP
Drug	Beclomethasone dipropionate [5534-09-8]; Down 200; 7.6uM; PC3; HT_HG-U133A	SYNJ2 TNK2 SH3D21	6.43e-04	196	20	3	4580_DN
Drug	Etomidate [33125-97-2]; Up 200; 16.4uM; HL60; HT_HG-U133A	SYNJ2 SH3D21 AGAP2	6.43e-04	196	20	3	2958_UP
Drug	fluphenazine dihydrochloride; Down 200; 10uM; MCF7; HT_HG-U133A	TNNT1 ADAM10 PIK3R1	6.43e-04	196	20	3	1662_DN
Drug	Piperine [94-62-2]; Down 200; 14uM; HL60; HT_HG-U133A	TNNT1 ADAM10 SOS2	6.43e-04	196	20	3	1327_DN
Drug	Meclofenamic acid sodium salt monohydrate [6385-02-0]; Down 200; 11.8uM; MCF7; HT_HG-U133A	SYNJ2 KMT2B SOS2	6.43e-04	196	20	3	2291_DN
Drug	D-cycloserine [68-41-7]; Down 200; 39.2uM; MCF7; HT_HG-U133A	SYNJ2 KMT2B SOS2	6.43e-04	196	20	3	6782_DN
Drug	Dioxybenzone [131-53-3]; Down 200; 16.4uM; HL60; HT_HG-U133A	ADAM10 TEC SOS2	6.43e-04	196	20	3	3101_DN
Drug	Carbimazole [22232-54-8]; Down 200; 21.4uM; HL60; HT_HG-U133A	SYNJ2 AGAP2 KMT2B	6.43e-04	196	20	3	2437_DN
Drug	Colistin sulfate [1264-72-8]; Down 200; 3uM; MCF7; HT_HG-U133A	SETD1A KMT2B SOS2	6.43e-04	196	20	3	2851_DN
Drug	Dienestrol [84-17-3]; Down 200; 15uM; MCF7; HT_HG-U133A	ADAM10 TNK2 SOS2	6.43e-04	196	20	3	3448_DN
Drug	Prednisolone [50-24-8]; Up 200; 11uM; MCF7; HT_HG-U133A	SYNJ2 AGAP2 SOS2	6.43e-04	196	20	3	7424_UP
Drug	Fluspirilen [1841-19-6]; Down 200; 8.4uM; HL60; HT_HG-U133A	TNNT1 SETD1A TNK2	6.43e-04	196	20	3	3086_DN
Drug	Sulfadiazine [68-35-9]; Up 200; 16uM; PC3; HT_HG-U133A	ADAM10 SETD1A SOS2	6.43e-04	196	20	3	1810_UP
Drug	estradiol, USP; Down 200; 0.1uM; PC3; HT_HG-U133A	PIK3R1 KMT2B SOS2	6.52e-04	197	20	3	1208_DN
Drug	Pilocarpine nitrate [148-72-1]; Down 200; 14.8uM; MCF7; HT_HG-U133A	SYNJ2 KMT2B SOS2	6.52e-04	197	20	3	5341_DN
Drug	Guaifenesin [93-14-1]; Down 200; 20.2uM; MCF7; HT_HG-U133A	SETD1A TNK2 SOS2	6.52e-04	197	20	3	4371_DN
Drug	Ethamsylate [2624-44-4]; Down 200; 15.2uM; HL60; HT_HG-U133A	ADAM10 TEC SOS2	6.52e-04	197	20	3	2915_DN
Drug	Orphenadrine hydrochloride [341-69-5]; Up 200; 13uM; PC3; HT_HG-U133A	SH3D21 KMT2B SOS2	6.52e-04	197	20	3	3801_UP
Drug	Piperacetazine [3819-00-9]; Up 200; 9.8uM; HL60; HT_HG-U133A	SYNJ2 SH3D21 AGAP2	6.52e-04	197	20	3	6152_UP
Drug	Indoprofen [31842-01-0]; Up 200; 14.2uM; PC3; HT_HG-U133A	SYNJ2 CACNA1S TNK2	6.52e-04	197	20	3	4249_UP
Drug	Praziquantel [55268-74-1]; Up 200; 12.8uM; MCF7; HT_HG-U133A	SETD1A TNK2 AGAP2	6.52e-04	197	20	3	3189_UP
Drug	Harmane hydrochloride [21655-84-5]; Down 200; 18.2uM; HL60; HT_HG-U133A	TNNT1 SYNJ2 AGAP2	6.52e-04	197	20	3	2150_DN
Drug	Lomefloxacin hydrochloride [98079-52-8]; Down 200; 10.4uM; PC3; HT_HG-U133A	ADAM10 SETD1A SOS2	6.52e-04	197	20	3	3723_DN
Drug	Iopromide [73334-07-3]; Down 200; 5uM; PC3; HT_HG-U133A	TNK2 PIK3R1 SOS2	6.52e-04	197	20	3	4504_DN
Drug	Thiamphenicol [15318-45-3]; Up 200; 11.2uM; PC3; HT_HG-U133A	SYNJ2 KMT2B SOS2	6.52e-04	197	20	3	1826_UP
Drug	Tolbutamide [64-77-7]; Down 200; 14.8uM; MCF7; HT_HG-U133A	SYNJ2 TNK2 SOS2	6.52e-04	197	20	3	3886_DN
Drug	Methantheline bromide [53-46-3]; Up 200; 9.6uM; HL60; HT_HG-U133A	SYNJ2 AGAP2 TEC	6.52e-04	197	20	3	6137_UP
Drug	Arecoline hydrobromide [300-08-3]; Up 200; 17uM; PC3; HT_HG-U133A	PIK3R1 AGAP2 SOS2	6.52e-04	197	20	3	6322_UP
Drug	Acetohexamide [968-81-0]; Down 200; 12.4uM; HL60; HT_HG-U133A	SYNJ2 TNK2 TEC	6.52e-04	197	20	3	1870_DN
Drug	Altretamine [654-05-6]; Down 200; 19uM; HL60; HT_HG-U133A	TNNT1 SYNJ2 SOS2	6.52e-04	197	20	3	3090_DN
Drug	Minoxidil [38304-91-5]; Up 200; 19.2uM; MCF7; HT_HG-U133A	ADAM10 AGAP2 SOS2	6.52e-04	197	20	3	4800_UP
Drug	0198306-0000 [212631-61-3]; Up 200; 10uM; PC3; HT_HG-U133A	SETD1A TNK2 KMT2B	6.52e-04	197	20	3	7069_UP
Drug	Fluorometholone [426-13-1]; Down 200; 10.6uM; PC3; HT_HG-U133A	SYNJ2 TNK2 SOS2	6.52e-04	197	20	3	5771_DN
Drug	Melatonin [73-31-4]; Up 200; 17.2uM; MCF7; HT_HG-U133A	CACNA1S AGAP2 SOS2	6.52e-04	197	20	3	3293_UP
Drug	Tropicamide [1508-75-4]; Down 200; 14uM; PC3; HT_HG-U133A	ADAM10 PIK3R1 SOS2	6.52e-04	197	20	3	3722_DN
Drug	Praziquantel [55268-74-1]; Up 200; 12.8uM; MCF7; HT_HG-U133A	SETD1A SH3D21 SOS2	6.52e-04	197	20	3	7228_UP
Drug	Lidoflazine [3416-26-0]; Up 200; 8.2uM; MCF7; HT_HG-U133A	SETD1A SH3D21 AGAP2	6.52e-04	197	20	3	3201_UP
Drug	Pyridoxine hydrochloride [58-56-0]; Up 200; 19.4uM; MCF7; HT_HG-U133A	SYNJ2 SH3D21 SOS2	6.52e-04	197	20	3	2751_UP
Drug	Hemicholinium bromide [312-45-8]; Down 200; 7uM; MCF7; HT_HG-U133A	SYNJ2 SETD1A SOS2	6.52e-04	197	20	3	3216_DN
Disease	tyrosine-protein kinase TEC measurement	TEC TEC	2.89e-06	4	21	2	EFO_0020830
Disease	thigh muscle volume	CACNA1S PIK3R1	7.22e-06	6	21	2	EFO_0020107
Disease	cortical thickness	ADAM10 DENND1A PIK3R1 SH3PXD2B KMT2B SOS2 RREB1	7.79e-06	1113	21	7	EFO_0004840
Disease	cystathionine measurement	TEC TEC	8.19e-05	19	21	2	EFO_0010474
Disease	vital capacity	CACNA1S PIK3R1 HES7 ERRFI1 SOS2 RREB1	1.68e-04	1236	21	6	EFO_0004312
Disease	prostate cancer (is_marker_for)	PIK3R1 AGAP2 KMT2B	1.80e-04	156	21	3	DOID:10283 (is_marker_for)
Disease	rheumatoid arthritis, anti-citrullinated protein antibody seropositivity, rheumatoid factor seropositivity measurement	TEC KMT2B TEC	2.32e-04	170	21	3	EFO_0000685, EFO_0007791, EFO_0007837
Disease	rheumatoid arthritis	DENND1A TEC KMT2B TEC	2.87e-04	462	21	4	EFO_0000685
Disease	myositis	TEC TEC	3.52e-04	39	21	2	EFO_0000783
Disease	abdominal fat cell number	ADAM10 TEC TEC	3.62e-04	198	21	3	EFO_0021534
Disease	creatinine measurement	CACNA1S TNK2 PIK3R1 SOS2 RREB1	5.60e-04	995	21	5	EFO_0004518
Disease	migraine disorder, type 2 diabetes mellitus	DENND1A RREB1	8.33e-04	60	21	2	MONDO_0005148, MONDO_0005277

Protein segments in the cluster

Peptide	Gene	Start	Entry
PPPKPLPGTLKRRRP	ADAM10	711	O14672
RRLKVAPPPPAPKPC	AGAP2	176	Q99490
KPQVPPRVPIPPRPT	TNK2	736	Q07912
PPKPPKVEVSPVLRP	KMT2B	551	Q9UMN6
KISPPTPKPRPPRPL	PIK3R1	81	P27986
PKKPVPEILPRPPRA	CACNA1S	16	Q13698
TKIPIRLPPARPPTP	GAS2L2	501	Q8NHY3
IPVPPPRTPRIVKKP	HUNK	521	P57058
KTPELGIVPPPPIPR	DENND1A	706	Q8TEH3
LRPKPPRPKPVDPRP	HES7	126	Q9BYE0
PVVLKPIPTKPAVPP	FAM181A	331	Q8N9Y4
KPSRPVVPPLIPPKI	TNNT1	41	P13805
PPPKVKPRVPVPTGA	SOS2	1181	Q07890
VLPPPPIKKLVPRKV	SH3D21	121	A4FU49
PVVTAPRVPPVPKPR	SYNJ2	1276	O15056
PETKKRRPPPPIPLE	TEC	161	P42680
PIVVTVPRPPPRPPK	TGFBR3L	231	H3BV60
PSSPIPLLPPPKKRR	SETD1A	1151	O15047
PEVPPRVPIPPRPVK	ERRFI1	281	Q9UJM3
RPKPPLLLPKPPVTE	RREB1	1046	Q92766
VVPPRRPPPPKKTSS	SH3PXD2B	756	A1X283