Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1A CACNA1C CACNA1F CACNA1G	3.90e-07	14	91	4	GO:0008331
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNA1A CACNA1C CACNA1F RIMBP2 CACNA1G	2.08e-06	46	91	5	GO:0005245
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in AV node cell action potential	CACNA1C CACNA1G	6.14e-05	3	91	2	GO:0086056
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in cardiac muscle cell action potential	CACNA1C CACNA1G	2.04e-04	5	91	2	GO:0086007
GeneOntologyMolecularFunction	calcium channel activity	CACNA1A CACNA1C CACNA1F RIMBP2 CACNA1G	3.10e-04	129	91	5	GO:0005262
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CACNA1A CACNA1C CACNA1F RIMBP2 CACNA1G	6.38e-04	151	91	5	GO:0015085
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	CACNA1A CACNA1C CACNA1F RIMBP2 CACNA1G	6.57e-04	152	91	5	GO:0022843
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels	CACNA1A RIMBP2	7.24e-04	9	91	2	GO:0099511
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	CACNA1A RIMBP2	7.24e-04	9	91	2	GO:0099626
GeneOntologyMolecularFunction	ubiquitin protein ligase binding	PER3 SH3KBP1 BAG1 TRIOBP TNFRSF1B DNAJB2 BAG6	8.82e-04	337	91	7	GO:0031625
GeneOntologyMolecularFunction	molecular adaptor activity	FBXO38 IGF2BP2 ABI1 TCF20 SYNM SETD5 MARK4 SH3KBP1 DNAJB2 MIDEAS NIPBL BAG6 CSTPP1 TBL1X FOXP3	1.15e-03	1356	91	15	GO:0060090
GeneOntologyMolecularFunction	ubiquitin-like protein ligase binding	PER3 SH3KBP1 BAG1 TRIOBP TNFRSF1B DNAJB2 BAG6	1.25e-03	358	91	7	GO:0044389
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	CACNA1A CACNA1C CACNA1F SLC20A2 RIMBP2 CACNA1G CPOX SLC30A4	1.28e-03	465	91	8	GO:0046873
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	CACNA1A CACNA1C CACNA1F RIMBP2 CACNA1G	1.47e-03	182	91	5	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	CACNA1A CACNA1C CACNA1F RIMBP2 CACNA1G	1.54e-03	184	91	5	GO:0022832
GeneOntologyMolecularFunction	ATPase regulator activity	BAG1 BRSK2 DNAJB2	1.92e-03	54	91	3	GO:0060590
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	FBXO38 IGF2BP2 ABI1 TCF20 SYNM SETD5 MARK4 DNAJB2 MIDEAS NIPBL CSTPP1 TBL1X FOXP3	2.25e-03	1160	91	13	GO:0030674
GeneOntologyMolecularFunction	polyubiquitin modification-dependent protein binding	ASCC2 DNAJB2 BAG6	2.48e-03	59	91	3	GO:0031593
GeneOntologyCellularComponent	voltage-gated calcium channel complex	CACNA1A CACNA1C CACNA1F CACNA1G	5.19e-05	46	93	4	GO:0005891
GeneOntologyCellularComponent	keratohyalin granule	FLG HRNR	1.94e-04	5	93	2	GO:0036457
GeneOntologyCellularComponent	calcium channel complex	CACNA1A CACNA1C CACNA1F CACNA1G	3.16e-04	73	93	4	GO:0034704
HumanPheno	Abnormal social development	SOX4 CACNA1A CACNA1C FLG DGCR2 BRF1 TCF20 EIF4H SETD5 GLDC DNAJC30 SH3KBP1 DCHS1 DEPDC5 CACNA1G HUWE1 HERC1 NIPBL WDR62 TBL1X	3.21e-06	908	40	20	HP:0025732
HumanPheno	Impairment in personality functioning	SOX4 CACNA1A CACNA1C FLG DGCR2 BRF1 TCF20 PER3 EIF4H SETD5 GLDC SLC20A2 DNAJC30 SH3KBP1 DCHS1 DEPDC5 CACNA1G HUWE1 CPOX NIPBL WDR62 TBL1X	6.99e-06	1141	40	22	HP:0031466
HumanPheno	Hyperactivity	SOX4 CACNA1A CACNA1C FLG TCF20 EIF4H SETD5 GLDC DNAJC30 SH3KBP1 DEPDC5 HUWE1 NIPBL WDR62 TBL1X	9.60e-06	558	40	15	HP:0000752
HumanPheno	Disinhibition	SOX4 CACNA1A CACNA1C FLG DGCR2 BRF1 TCF20 EIF4H SETD5 GLDC DNAJC30 SH3KBP1 DCHS1 DEPDC5 HUWE1 NIPBL WDR62 TBL1X	1.16e-05	807	40	18	HP:0000734
HumanPheno	Inappropriate behavior	SOX4 CACNA1A CACNA1C FLG DGCR2 BRF1 TCF20 EIF4H SETD5 GLDC DNAJC30 SH3KBP1 DCHS1 DEPDC5 HUWE1 NIPBL WDR62 TBL1X	1.16e-05	807	40	18	HP:0000719
HumanPheno	Abnormal response to social norms	SOX4 CACNA1A CACNA1C FLG DGCR2 BRF1 TCF20 EIF4H SETD5 GLDC DNAJC30 SH3KBP1 DCHS1 DEPDC5 HUWE1 NIPBL WDR62 TBL1X	1.16e-05	807	40	18	HP:5200123
HumanPheno	Social disinhibition	SOX4 CACNA1A CACNA1C FLG DGCR2 BRF1 TCF20 EIF4H SETD5 GLDC DNAJC30 SH3KBP1 DCHS1 DEPDC5 HUWE1 NIPBL WDR62 TBL1X	1.16e-05	807	40	18	HP:5200029
HumanPheno	Abnormally increased volition	SOX4 CACNA1A CACNA1C FLG DGCR2 BRF1 TCF20 EIF4H SETD5 GLDC DNAJC30 SH3KBP1 DCHS1 DEPDC5 HUWE1 NIPBL WDR62 TBL1X	3.32e-05	869	40	18	HP:5200263
HumanPheno	Abnormal motivation	SOX4 CACNA1A CACNA1C FLG DGCR2 BRF1 TCF20 PER3 EIF4H SETD5 GLDC SLC20A2 DNAJC30 SH3KBP1 DCHS1 DEPDC5 CACNA1G HUWE1 CPOX NIPBL WDR62 TBL1X	3.94e-05	1263	40	22	HP:5200275
HumanPheno	Abnormal volitional state	SOX4 CACNA1A CACNA1C FLG DGCR2 BRF1 TCF20 PER3 EIF4H SETD5 GLDC SLC20A2 DNAJC30 SH3KBP1 DCHS1 DEPDC5 CACNA1G HUWE1 CPOX NIPBL WDR62 TBL1X	3.94e-05	1263	40	22	HP:0025780
Domain	VDCCAlpha1	CACNA1A CACNA1C CACNA1F CACNA1G	1.13e-07	10	92	4	IPR002077
Domain	VDCC_a1su_IQ	CACNA1A CACNA1C CACNA1F	3.99e-06	7	92	3	IPR014873
Domain	GPHH	CACNA1A CACNA1C CACNA1F	3.99e-06	7	92	3	PF16905
Domain	GPHH_dom	CACNA1A CACNA1C CACNA1F	3.99e-06	7	92	3	IPR031649
Domain	Ca_chan_IQ	CACNA1A CACNA1C CACNA1F	3.99e-06	7	92	3	SM01062
Domain	Ca_chan_IQ	CACNA1A CACNA1C CACNA1F	3.99e-06	7	92	3	PF08763
Domain	CAC1F_C	CACNA1C CACNA1F	7.18e-05	3	92	2	IPR031688
Domain	CAC1F_C	CACNA1C CACNA1F	7.18e-05	3	92	2	PF16885
Domain	VDCC_L_a1su	CACNA1C CACNA1F	1.43e-04	4	92	2	IPR005446
Domain	Channel_four-helix_dom	CACNA1A CACNA1C CACNA1F CACNA1G	1.78e-04	57	92	4	IPR027359
Domain	-	CACNA1A CACNA1C CACNA1F CACNA1G	1.78e-04	57	92	4	1.20.120.350
Domain	DUF1669	FAM83G FAM83A	6.59e-04	8	92	2	IPR012461
Domain	DUF1669	FAM83G FAM83A	6.59e-04	8	92	2	PF07894
Domain	CUB	ATRN LRP12 SCUBE3	1.81e-03	49	92	3	PF00431
Domain	CUB	ATRN LRP12 SCUBE3	1.92e-03	50	92	3	SM00042
Domain	Cadherin_CS	DCHS2 DCHS1 PCDH10 PCDH7	2.07e-03	109	92	4	IPR020894
Domain	-	ATRN LRP12 SCUBE3	2.15e-03	52	92	3	2.60.120.290
Domain	CUB	ATRN LRP12 SCUBE3	2.27e-03	53	92	3	PS01180
Domain	CADHERIN_1	DCHS2 DCHS1 PCDH10 PCDH7	2.36e-03	113	92	4	PS00232
Domain	Cadherin	DCHS2 DCHS1 PCDH10 PCDH7	2.36e-03	113	92	4	PF00028
Domain	Ion_trans_dom	CACNA1A CACNA1C CACNA1F CACNA1G	2.43e-03	114	92	4	IPR005821
Domain	Ion_trans	CACNA1A CACNA1C CACNA1F CACNA1G	2.43e-03	114	92	4	PF00520
Domain	CADHERIN_2	DCHS2 DCHS1 PCDH10 PCDH7	2.43e-03	114	92	4	PS50268
Domain	-	DCHS2 DCHS1 PCDH10 PCDH7	2.43e-03	114	92	4	2.60.40.60
Domain	CA	DCHS2 DCHS1 PCDH10 PCDH7	2.51e-03	115	92	4	SM00112
Domain	Cadherin-like	DCHS2 DCHS1 PCDH10 PCDH7	2.59e-03	116	92	4	IPR015919
Domain	Cadherin	DCHS2 DCHS1 PCDH10 PCDH7	2.76e-03	118	92	4	IPR002126
Domain	CUB_dom	ATRN LRP12 SCUBE3	2.79e-03	57	92	3	IPR000859
Domain	RCC1	MYCBP2 HERC1	4.30e-03	20	92	2	PF00415
Domain	RCC1_1	MYCBP2 HERC1	4.74e-03	21	92	2	PS00625
Domain	RCC1_2	MYCBP2 HERC1	4.74e-03	21	92	2	PS00626
Domain	RCC1_3	MYCBP2 HERC1	4.74e-03	21	92	2	PS50012
Domain	Ca/CaM-dep_Ca-dep_prot_Kinase	MARK4 BRSK2 ULK2	4.79e-03	69	92	3	IPR020636
Pathway	KEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY	CACNA1A CACNA1C CACNA1F CACNA1G	3.01e-06	23	63	4	M47666
Pathway	KEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL	CACNA1A CACNA1C CACNA1F CACNA1G	4.27e-06	25	63	4	M47948
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1A CACNA1C CACNA1F CACNA1G	6.79e-09	9	96	4	16382099
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DGCR2 EIF4H MYCBP2 SYNM CASKIN2 DNAJC30 BAG1 GATB NFXL1 ASCC2 TRIOBP PAF1 GPRIN1 DNAJB2 MAP4K4 PCDH7 BAG6 WDR62 CDC42EP1	2.12e-08	1487	96	19	33957083
Pubmed	Functional importance of L- and P/Q-type voltage-gated calcium channels in human renal vasculature.	CACNA1A CACNA1C CACNA1G	8.14e-08	4	96	3	21788606
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	ABI1 TCF20 MYCBP2 CASKIN2 EXPH5 MARK4 BRSK2 FAM83G BOD1L1 CAMSAP2 MAP4K4 PCDH7 WDR62 CDC42EP1	1.07e-07	861	96	14	36931259
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CACNA1A ABI1 TCF20 MYCBP2 SH3KBP1 DCHS1 TRIOBP RIMBP2 HUWE1 PAF1 CAMSAP2 MAP4K4 NIPBL TBL1X	4.13e-07	963	96	14	28671696
Pubmed	Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.	CACNA1C CACNA1F CACNA1G	7.08e-07	7	96	3	12900400
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	FBXO38 IGF2BP2 PTPRH MYCBP2 CASKIN2 CD44 SLTM TRIOBP HUWE1 HERC1 PAF1 GPRIN1 PCDH7 CDC42EP1	1.14e-06	1049	96	14	27880917
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	RABL6 CACNA1C DCHS2 EXPH5 ASCC2 HERC1 GPRIN1 MAP4K4 BAG6 HYDIN	1.22e-06	497	96	10	36774506
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	FBXO38 TCF20 MYCBP2 PKP3 RBM15B HUWE1 GPRIN1 MAP4K4 PCDH7 NIPBL BAG6 WDR62	1.53e-06	774	96	12	15302935
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TCF20 EIF4H SETD5 MARK4 RIMBP2 BOD1L1 CAMSAP2 PCDH10 ULK2	1.99e-06	407	96	9	12693553
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	CACNA1A CACNA1C CACNA1F CACNA1G	3.74e-06	38	96	4	30786075
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	CACNA1A CACNA1C ABI1 MYCBP2 SH3KBP1 BRSK2 RIMBP2 GPRIN1	5.60e-06	347	96	8	17114649
Pubmed	Associations of Variants in the CACNA1A and CACNA1C Genes With Longitudinal Blood Pressure Changes and Hypertension Incidence: The GenSalt Study.	CACNA1A CACNA1C	7.54e-06	2	96	2	27418245
Pubmed	CD44 expression positively correlates with Foxp3 expression and suppressive function of CD4+ Treg cells.	CD44 FOXP3	7.54e-06	2	96	2	19852824
Pubmed	Migratory capacity and function of dendritic cells from mesenteric afferent lymph nodes after feeding a single dose of vitamin A.	CD44 FOXP3	7.54e-06	2	96	2	28917953
Pubmed	CD44 induces FOXP3 expression and is related with favorable outcome in breast carcinoma.	CD44 FOXP3	7.54e-06	2	96	2	27885422
Pubmed	L-type calcium channels contribute to the tottering mouse dystonic episodes.	CACNA1A CACNA1C	7.54e-06	2	96	2	9882694
Pubmed	Atopic Dermatitis Susceptibility Variants in Filaggrin Hitchhike Hornerin Selective Sweep.	FLG HRNR	7.54e-06	2	96	2	27678121
Pubmed	FOXP3 suppresses breast cancer metastasis through downregulation of CD44.	CD44 FOXP3	7.54e-06	2	96	2	25683728
Pubmed	A Selectivity Filter Gate Controls Voltage-Gated Calcium Channel Calcium-Dependent Inactivation.	CACNA1A CACNA1C	7.54e-06	2	96	2	30733149
Pubmed	Subthreshold membrane potential oscillations in inferior olive neurons are dynamically regulated by P/Q- and T-type calcium channels: a study in mutant mice.	CACNA1A CACNA1G	7.54e-06	2	96	2	20547676
Pubmed	Inhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitis.	CD44 FOXP3	7.54e-06	2	96	2	26368307
Pubmed	Expression of costimulatory TNFR2 induces resistance of CD4+FoxP3- conventional T cells to suppression by CD4+FoxP3+ regulatory T cells.	TNFRSF1B FOXP3	7.54e-06	2	96	2	20525892
Pubmed	Regulatory T Cells Expressing Tumor Necrosis Factor Receptor Type 2 Play a Major Role in CD4+ T-Cell Impairment During Sepsis.	TNFRSF1B FOXP3	7.54e-06	2	96	2	32697326
Pubmed	TNFR2 on non-haematopoietic cells is required for Foxp3+ Treg-cell function and disease suppression in EAE.	TNFRSF1B FOXP3	7.54e-06	2	96	2	22105853
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	RABL6 TCF20 SYNM CASKIN2 EXPH5 MAP4K4 CSTPP1	8.77e-06	263	96	7	34702444
Pubmed	Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.	CACNA1A CACNA1C CACNA1F	9.05e-06	15	96	3	20188150
Pubmed	Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.	CACNA1A CACNA1C CACNA1F	9.05e-06	15	96	3	24453333
Pubmed	Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS.	CASKIN2 PKP3 SH3KBP1 FAM83G MIDEAS	1.28e-05	108	96	5	19531213
Pubmed	Association study between polymorphisms in the CACNA1A, CACNA1C, and CACNA1H genes and drug-resistant epilepsy in the Chinese Han population.	CACNA1A CACNA1C	2.26e-05	3	96	2	26216687
Pubmed	Osteopontin and iCD8α Cells Promote Intestinal Intraepithelial Lymphocyte Homeostasis.	CD44 FOXP3	2.26e-05	3	96	2	32102904
Pubmed	Retinitis pigmentosa 2 pathogenic mutants degrade through BAG6/HUWE1 complex.	HUWE1 BAG6	2.26e-05	3	96	2	35569519
Pubmed	Tissue-restricted control of established central nervous system autoimmunity by TNF receptor 2-expressing Treg cells.	TNFRSF1B FOXP3	2.26e-05	3	96	2	33766913
Pubmed	Intrinsic TNFR2 signaling in T regulatory cells provides protection in CNS autoimmunity.	TNFRSF1B FOXP3	2.26e-05	3	96	2	30498033
Pubmed	T-type, but not L-type, voltage-gated calcium channels are dispensable for lymphatic pacemaking and spontaneous contractions.	CACNA1C CACNA1G	2.26e-05	3	96	2	31919478
Pubmed	Molecular Basis of Regulating High Voltage-Activated Calcium Channels by S-Nitrosylation.	CACNA1A CACNA1C	2.26e-05	3	96	2	26507659
Pubmed	TNF Receptor-2 Facilitates an Immunosuppressive Microenvironment in the Liver to Promote the Colonization and Growth of Hepatic Metastases.	TNFRSF1B FOXP3	2.26e-05	3	96	2	26483205
Pubmed	Truncation of murine CaV1.2 at Asp 1904 increases CaV1.3 expression in embryonic atrial cardiomyocytes.	CACNA1A CACNA1C	2.26e-05	3	96	2	23338940
Pubmed	CD44 costimulation promotes FoxP3+ regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta.	CD44 FOXP3	2.26e-05	3	96	2	19635906
Pubmed	Association of single nucleotide polymorphisms in CACNA 1A/CACNA 1C/CACNA 1H calcium channel genes with diabetic peripheral neuropathy in Chinese population.	CACNA1A CACNA1C	2.26e-05	3	96	2	29581247
Pubmed	Tachypacing-induced CREB/CD44 signaling contributes to the suppression of L-type calcium channel expression and the development of atrial remodeling.	CACNA1C CD44	2.26e-05	3	96	2	34023501
Pubmed	Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance.	SIGLEC1 FOXP3	2.26e-05	3	96	2	30413362
Pubmed	Loss of calcium channels in the cerebellum of the ataxic and epileptic stargazer mutant mouse.	CACNA1A CACNA1C	2.26e-05	3	96	2	19422811
Pubmed	Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice.	CACNA1C CACNA1G	2.26e-05	3	96	2	22133878
Pubmed	Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.	FLG HRNR	2.26e-05	3	96	2	23403047
Pubmed	Biallelic variants in genes previously associated with dominant inheritance: CACNA1A, RET and SLC20A2.	CACNA1A SLC20A2	2.26e-05	3	96	2	34267336
Pubmed	Electric field stimulation unmasks a subtle role for T-type calcium channels in regulating lymphatic contraction.	CACNA1C CACNA1G	2.26e-05	3	96	2	37739992
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	ABI1 CSNK1G3 TRIOBP GPRIN1 MAP4K4 PCDH7 CSTPP1 CDC42EP1	2.26e-05	421	96	8	36976175
Pubmed	Functional proteomics mapping of a human signaling pathway.	DGCR2 MYCBP2 EXPH5 ASCC2 HUWE1 HERC1 DNAJB2 BAG6 INVS	3.88e-05	591	96	9	15231748
Pubmed	Adult loss of Cacna1a in mice recapitulates childhood absence epilepsy by distinct thalamic bursting mechanisms.	CACNA1A CACNA1G	4.51e-05	4	96	2	31800012
Pubmed	Beta-adrenergic-regulated phosphorylation of the skeletal muscle Ca(V)1.1 channel in the fight-or-flight response.	CACNA1C CACNA1F	4.51e-05	4	96	2	20937870
Pubmed	How defects in central tolerance impinge on a deficiency in regulatory T cells.	CD44 FOXP3	4.51e-05	4	96	2	16203996
Pubmed	Natural but not inducible regulatory T cells require TNF-alpha signaling for in vivo function.	TNFRSF1B FOXP3	4.51e-05	4	96	2	21572024
Pubmed	Genetic variants harbored in the forkhead box protein 3 locus increase hay fever risk.	CACNA1F FOXP3	4.51e-05	4	96	2	20398921
Pubmed	CircCD44 plays oncogenic roles in triple-negative breast cancer by modulating the miR-502-5p/KRAS and IGF2BP2/Myc axes.	IGF2BP2 CD44	4.51e-05	4	96	2	34696797
Pubmed	Role of the alpha1G T-type calcium channel in spontaneous absence seizures in mutant mice.	CACNA1A CACNA1G	4.51e-05	4	96	2	15175395
Pubmed	Planar cell polarity-dependent asymmetric organization of microtubules for polarized positioning of the basal body in node cells.	DCHS2 DCHS1	4.51e-05	4	96	2	35420656
Pubmed	A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C.	CACNA1A CACNA1C	4.51e-05	4	96	2	15728831
Pubmed	Fragile TIM-4-expressing tissue resident macrophages are migratory and immunoregulatory.	SIGLEC1 FOXP3	4.51e-05	4	96	2	24983317
Pubmed	E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb alpha.	MYCBP2 HUWE1	4.51e-05	4	96	2	20534529
Pubmed	G protein-gated inhibitory module of N-type (ca(v)2.2) ca2+ channels.	CACNA1A CACNA1C	4.51e-05	4	96	2	15953418
Pubmed	The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function.	FBXO38 CPOX HRNR	5.68e-05	27	96	3	28007894
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	RABL6 SYNM CD44 HUWE1 HRNR GPRIN1 PCDH10 PCDH7 SPTY2D1 CDC42EP1	5.85e-05	777	96	10	35844135
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ATRN CACNA1C MYCBP2 SETD5 PKP3 TRIOBP EVC BOD1L1 SPIDR HUWE1 SLC30A4 INVS TBL1X FAM149A	5.85e-05	1489	96	14	28611215
Pubmed	Phosphoproteomic analysis of the developing mouse brain.	SOX4 SYBU HUWE1 CAMSAP2 MAP4K4 CDC42EP1	6.42e-05	246	96	6	15345747
Pubmed	Transmembrane TNF-TNFR2 Impairs Th17 Differentiation by Promoting Il2 Expression.	TNFRSF1B FOXP3	7.50e-05	5	96	2	26268655
Pubmed	Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.	CACNA1A CACNA1C	7.50e-05	5	96	2	11296258
Pubmed	Biallelic variants in TSPOAP1, encoding the active-zone protein RIMBP1, cause autosomal recessive dystonia.	CACNA1A RIMBP2	7.50e-05	5	96	2	33539324
Pubmed	Identification of a cardiac isoform of the murine calcium channel alpha1C (Cav1.2-a) subunit and its preferential binding with the beta2 subunit.	CACNA1A CACNA1C	7.50e-05	5	96	2	16787652
Pubmed	Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.	CACNA1A CACNA1C	7.50e-05	5	96	2	15451373
Pubmed	CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity.	DEPDC5 FOXP3	7.50e-05	5	96	2	34795452
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	CASKIN2 SLC20A2 CSNK1G3 CD44 GPRIN1 MAP4K4 CDC42EP1	8.67e-05	377	96	7	38117590
Pubmed	Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.	ATRN ABI1 EIF4H GATB PGM2 CDC42EP1	9.27e-05	263	96	6	12665801
Pubmed	Where CD4+CD25+ T reg cells impinge on autoimmune diabetes.	CD44 FOXP3	1.12e-04	6	96	2	16301745
Pubmed	Genotype and phenotype of 101 dutch patients with congenital stationary night blindness.	CACNA1F GPR179	1.12e-04	6	96	2	23714322
Pubmed	TNFR2 is critical for the stabilization of the CD4+Foxp3+ regulatory T. cell phenotype in the inflammatory environment.	TNFRSF1B FOXP3	1.12e-04	6	96	2	23277487
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	IGF2BP2 TCF20 EIF4H MYCBP2 PKP3 SLTM HUWE1 HRNR MAP4K4 NIPBL BAG6	1.23e-04	1024	96	11	24711643
Pubmed	Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.	HUWE1 BAG6 CDC42EP1	1.36e-04	36	96	3	35379950
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	TCF20 MYCBP2 BOD1L1 HUWE1 PAF1 GPRIN1 MIDEAS MAP4K4	1.44e-04	549	96	8	38280479
Pubmed	Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila.	DCHS2 DCHS1	1.57e-04	7	96	2	16059920
Pubmed	The mouse mahogany locus encodes a transmembrane form of human attractin.	ATRN SIGLEC1	1.57e-04	7	96	2	10086356
Pubmed	Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain.	BAG1 BAG6	1.57e-04	7	96	2	25535373
Pubmed	DC-SIGN(+) Macrophages Control the Induction of Transplantation Tolerance.	SIGLEC1 FOXP3	1.57e-04	7	96	2	26070485
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	ABI1 CASKIN2 EXPH5 SLC20A2 CD44 MAP4K4 PCDH7 CDC42EP1	1.84e-04	569	96	8	30639242
Pubmed	Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	EXPH5 DEPDC5 MAP4K4 ULK2	1.88e-04	102	96	4	9734811
Pubmed	Stability and function of regulatory T cells expressing the transcription factor T-bet.	CD44 FOXP3	2.09e-04	8	96	2	28607488
Pubmed	Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.	CACNA1F CACNA1G	2.09e-04	8	96	2	28330839
Pubmed	Neuronal calcium sensor-1 promotes immature heart function and hypertrophy by enhancing Ca2+ signals.	CACNA1C CACNA1G	2.09e-04	8	96	2	21737792
Pubmed	Intracellular calcium plays an essential role in cardiac development.	CACNA1C CACNA1G	2.09e-04	8	96	2	12761855
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	LRP12 RBM15B BOD1L1 HUWE1 MAP4K4 BAG6	2.38e-04	313	96	6	38270169
Pubmed	Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells.	CD44 FOXP3	2.68e-04	9	96	2	25065622
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	CACNA1A ABI1 MYCBP2 SH3KBP1 BRSK2 TRIOBP HUWE1 GPRIN1 DNAJB2 CAMSAP2 MAP4K4	3.08e-04	1139	96	11	36417873
Pubmed	Association between insulin secretion, insulin sensitivity and type 2 diabetes susceptibility variants identified in genome-wide association studies.	IGF2BP2 TCF20	3.34e-04	10	96	2	19082521
Pubmed	The mahogany protein is a receptor involved in suppression of obesity.	ATRN SIGLEC1	3.34e-04	10	96	2	10086355
Pubmed	Cav3.2 T-type calcium channel is required for the NFAT-dependent Sox9 expression in tracheal cartilage.	CACNA1C CACNA1G	3.34e-04	10	96	2	24778262
Pubmed	Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population.	IGF2BP2 TCF20	3.34e-04	10	96	2	20509872
Pubmed	The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms.	FAM83G FAM83A	4.08e-04	11	96	2	29789297
Pubmed	The Auxiliary Calcium Channel Subunit α2δ4 Is Required for Axonal Elaboration, Synaptic Transmission, and Wiring of Rod Photoreceptors.	CACNA1F GPR179	4.08e-04	11	96	2	28262416
Pubmed	gp78 functions downstream of Hrd1 to promote degradation of misfolded proteins of the endoplasmic reticulum.	BAG1 BAG6	4.08e-04	11	96	2	26424800
Pubmed	NCAM induces CaMKIIalpha-mediated RPTPalpha phosphorylation to enhance its catalytic activity and neurite outgrowth.	CACNA1C CACNA1F	4.08e-04	11	96	2	18809727
GeneFamily	Calcium voltage-gated channel subunits	CACNA1A CACNA1C CACNA1F CACNA1G	1.09e-06	26	55	4	253
GeneFamily	BCL2 associated athanogene family	BAG1 BAG6	1.35e-04	6	55	2	1139
GeneFamily	EF-hand domain containing\|S100 fused type protein family	FLG HRNR	1.89e-04	7	55	2	1350
GeneFamily	Non-clustered protocadherins	PCDH10 PCDH7	5.88e-04	12	55	2	21
GeneFamily	Cadherin related	DCHS2 DCHS1	1.20e-03	17	55	2	24
GeneFamily	RNA binding motif containing	IGF2BP2 EIF4H SLTM RBM15B	3.99e-03	213	55	4	725
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	ATRN DGCR2	6.91e-03	41	55	2	1298
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HGABA	CACNA1A CACNA1C LRP12 BRF1 MYCBP2 SH3KBP1 SAMD5 BRSK2 RIMBP2 CHSY3 BOD1L1 CACNA1G SYBU HERC1 CAMSAP2 PCDH7 HYDIN CCDC85A	8.04e-08	1106	95	18	M39071
Coexpression	FAN_EMBRYONIC_CTX_EX_4_EXCITATORY_NEURON	CACNA1A CACNA1C SAMD5 CACNA1G SYBU DNAJB2 HYDIN	2.49e-06	166	95	7	M39026
Coexpression	GSE37301_HEMATOPOIETIC_STEM_CELL_VS_CD4_TCELL_DN	LRP12 BRSK2 CD44 EVC SIT1 PCDH7	1.62e-05	147	95	6	M8882
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HSERT	CACNA1A CACNA1C MYCBP2 SH3KBP1 RIMBP2 CACNA1G SYBU PCDH7 CCDC85A	3.81e-05	450	95	9	M39072
ToppCell	normal_Lung-T/NK_cells-CD8+/CD4+_Mixed_Th\|T/NK_cells / Location, Cell class and cell subclass	CACNA1A CPOX PAF1 MIDEAS MAP4K4 INVS	1.99e-06	172	96	6	0657c736f3c52d25cf7f652eac005ddcde9232ef
ToppCell	Skin\|World / Skin and Kidney Cells in Lupus Nephritis Patients.	FLG MYCBP2 EXPH5 PKP3 CD44 FAM83G	4.62e-06	199	96	6	6be1340413ee868c610b6e3f58c65b493eb22bb5
ToppCell	LPS_IL1RA\|World / Treatment groups by lineage, cell group, cell type	IGF2BP2 CD44 TNFRSF1B MAP4K4 CCDC85A CDC42EP1	4.76e-06	200	96	6	a02fa5b3c4723a6eaa3c685588666c710478dd25
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	CACNA1A CACNA1C MYCBP2 RIMBP2 CHSY3 HERC1	4.76e-06	200	96	6	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	Skin-Keratinocytes\|Skin / Skin and Kidney Cells in Lupus Nephritis Patients.	EXPH5 PKP3 BAG1 CD44 FAM83G HUWE1	4.76e-06	200	96	6	59d72395199bc30df0e811fbc99149694e208860
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SOX4 SCUBE3 SYBU HYDIN TMEM200B	2.09e-05	154	96	5	ec56b7fb88e39041416c384f371c767f3b4e92fa
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-immature_innate_lymphoid_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PKP3 SH3KBP1 CD44 SIT1 FAM83A	3.09e-05	167	96	5	5d1919bea8e5a52ac6fc953caff15509b7142923
ToppCell	Club_cells-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	SOX4 DCHS2 BRSK2 PCDH7 FAM83A	3.09e-05	167	96	5	dbdaaeb3bd9139cb008d9fe24ec031fc5628f136
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-immature_innate_lymphoid_cell-Ly6g5b+_T\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PKP3 SH3KBP1 CD44 SIT1 FAM83A	3.09e-05	167	96	5	d8f497860d48342a3aaaad328f88e4d55ab4faeb
ToppCell	5'-Adult-LargeIntestine-Epithelial-neuro-epithelial-EECs\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SOX4 CACNA1A SCUBE3 RIMBP2 GPRIN1	3.46e-05	171	96	5	dd37e1693a5cfc42e40992d504f92048a8038b52
ToppCell	COVID-19-kidney-vSMC/Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1C SYNM BRSK2 PCDH10 PGM2	4.30e-05	179	96	5	111b1084f73306bdeffaaf240e7dbb4f5bf33de1
ToppCell	COVID-19_Severe-RBC\|COVID-19_Severe / disease group, cell group and cell class	IGF2BP2 BAG1 ASCC2 DNAJB2 FAM83A	4.90e-05	184	96	5	bb58244194ffb5558fbe85c5f856888210dcb1e8
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HUWE1 MIDEAS CAMSAP2 MAP4K4 SPTY2D1	5.03e-05	185	96	5	eb7d3c1363d5fedc611f9c1a91ea823de251355e
ToppCell	pdx\|World / Sample and Cell Type and Tumor Cluster (all cells)	IGF2BP2 TCF20 GLDC SPIDR MAP4K4	5.16e-05	186	96	5	de8e538c8767d41b8a52f5e58ba1affd4e7244c4
ToppCell	5'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells-Treg\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SH3KBP1 CD44 TNFRSF1B SIT1 FOXP3	5.16e-05	186	96	5	2a9daf96c2a47f1ed5421130f32f17bd33e644a7
ToppCell	pdx-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	IGF2BP2 TCF20 GLDC SPIDR MAP4K4	5.16e-05	186	96	5	0b88a87158a9ca8de3bf40a4ff1687150707a5f0
ToppCell	ILEUM-inflamed-(8)_Fibroblast-(8)_Smooth_muscle_cells\|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	SOX4 SYNM SAMD5 SLC30A4 HYDIN	5.16e-05	186	96	5	cacc2f0b2ed46516173b61ba1c5c226a2db7cddc
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA1A PTPRH BRSK2 RIMBP2 FAM149A	5.16e-05	186	96	5	b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCell	pdx-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	TCF20 EXPH5 CD44 CPXM1 TBL1X	5.29e-05	187	96	5	7e376831a11ee72ed87abcdac631ca46ae29c250
ToppCell	facs-Kidney-nan-24m-Lymphocytic\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH3KBP1 CD44 TNFRSF1B SIT1 FAM83A	5.29e-05	187	96	5	e4cb79c7aa29e8c99d5a3a209d2f9a03c2ba9bb7
ToppCell	human_hepatoblastoma-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	TCF20 EXPH5 CD44 HYDIN TBL1X	5.43e-05	188	96	5	b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCell	droplet-Limb_Muscle-nan-3m-Endothelial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SAMD5 RBM15B ASCC2 SYBU CDC42EP1	5.56e-05	189	96	5	16a4c92dd7a0d60f3691bd3130a091a9a54730f1
ToppCell	5'-GW_trimst-2-LymphNode-Hematopoietic-T_cells-Treg\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SH3KBP1 CD44 TNFRSF1B SIT1 FOXP3	6.14e-05	193	96	5	f3eb295a019de29f484964f00ea436860af249a5
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	ATRN IGF2BP2 SETD5 MAP4K4 NIPBL	6.14e-05	193	96	5	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	Bronchus_Control_(B.)-Epithelial-TX-AT2-2\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	SYNM GLDC EVC PCDH10 TMEM200B	6.30e-05	194	96	5	5bfc26668fa8f109f2ebc0d5fd98ab5bd219e62c
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1A MYCBP2 BOD1L1 HUWE1 HERC1	6.45e-05	195	96	5	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1A MYCBP2 BOD1L1 HUWE1 HERC1	6.45e-05	195	96	5	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	(11)_FOXN4+-(2)_GFP_FOXI1\|(11)_FOXN4+ / shred by cell type by condition	MYCBP2 EXPH5 SLTM BOD1L1 NIPBL	6.93e-05	198	96	5	76d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell	tumor_Lung-Epithelial_cells-tS2\|tumor_Lung / Location, Cell class and cell subclass	SOX4 IGF2BP2 PKP3 FAM83A CDC42EP1	7.10e-05	199	96	5	28ec59e01061287fb0892491790b316e2b93e232
ToppCell	MS-IIF-Lymphocyte-T/NK-CD4+_CTL\|IIF / Disease, condition lineage and cell class	SYNM SLC20A2 RTN4RL2 SLC30A4 SIT1	7.10e-05	199	96	5	232f85175f49322eee903dd5e7d8e5a94c751ee0
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	IGF2BP2 CASKIN2 SYBU CCDC85A CDC42EP1	7.27e-05	200	96	5	bcd1cc96197929d6011903803b6f4ccdcf52b4ce
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Alv_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	IGF2BP2 CASKIN2 SYBU CCDC85A CDC42EP1	7.27e-05	200	96	5	7034f57e282982c19c13ee8ab78eabaffa069e30
Drug	Verapamil	CACNA1A CACNA1C CACNA1F CACNA1G	4.98e-07	16	95	4	DB00661
Drug	Benzylpenicillin sodium [69-57-8]; Up 200; 11.2uM; HL60; HT_HG-U133A	SOX4 BRF1 CASKIN2 CD44 DCHS1 SIT1 WDR62 FOXP3	1.88e-06	199	95	8	6155_UP
Drug	Cinnarizine	CACNA1C CACNA1F CACNA1G	5.80e-06	9	95	3	DB00568
Drug	gallopamil	CACNA1A CACNA1C CACNA1F CACNA1G PAF1	8.95e-06	67	95	5	CID000001234
Drug	CNS 1145	CACNA1A CACNA1C CACNA1F CACNA1G	1.06e-05	33	95	4	CID000190902
Drug	IHC-64	CACNA1A CACNA1C CACNA1F CACNA1G	1.06e-05	33	95	4	CID000162753
Drug	Mibefradil	CACNA1C CACNA1F CACNA1G	1.13e-05	11	95	3	DB01388
Drug	AC1L2VU3	CACNA1A SYNM CACNA1G	1.51e-05	12	95	3	CID000129572
Drug	Homatropine hydrobromide (R,S) [51-56-9]; Down 200; 11.2uM; PC3; HT_HG-U133A	FBXO38 LRP12 CASKIN2 EXPH5 PKP3 SPIDR ULK2	1.61e-05	192	95	7	5058_DN
Drug	Rapamycin; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA	DGCR2 LRP12 CASKIN2 MARK4 ASCC2 SPIDR CDC42EP1	1.66e-05	193	95	7	1022_DN
Drug	C-73	SIGLEC1 BAG6	1.72e-05	2	95	2	CID000192778
Drug	naphthyl)hydroxy-naftopidil	SYNM PAF1	1.72e-05	2	95	2	CID000131580
Drug	Nystatine [1400-61-9]; Up 200; 4.4uM; MCF7; HT_HG-U133A	FBXO38 CASKIN2 SLC20A2 MARK4 RIMBP2 WDR62 FOXP3	1.83e-05	196	95	7	4807_UP
Drug	genistein; Down 200; 10uM; MCF7; HT_HG-U133A_EA	RABL6 ATRN DGCR2 SYNM CAMSAP2 NIPBL TBL1X	1.90e-05	197	95	7	1015_DN
Drug	Hyoscyamine (L) [101-31-5]; Down 200; 13.8uM; MCF7; HT_HG-U133A	SOX4 LRP12 BRF1 MARK4 CD44 ASCC2 SPIDR	1.96e-05	198	95	7	5524_DN
Drug	Chlorogenic acid [327-97-9]; Up 200; 11.2uM; MCF7; HT_HG-U133A	LRP12 PER3 CASKIN2 EXPH5 DEPDC5 SPIDR CDC42EP1	1.96e-05	198	95	7	4142_UP
Drug	Budesonide [51333-22-3]; Down 200; 9.2uM; MCF7; HT_HG-U133A	ATRN LRP12 PER3 CASKIN2 MARK4 CD44 PCDH7	1.96e-05	198	95	7	5431_DN
Drug	Acetazolamide [59-66-5]; Down 200; 18uM; MCF7; HT_HG-U133A	ATRN FBXO38 DGCR2 PER3 CASKIN2 SPIDR CDC42EP1	2.02e-05	199	95	7	7461_DN
Drug	monastrol; Down 200; 100uM; PC3; HG-U133A	SOX4 DGCR2 MYCBP2 CD44 CPOX TBL1X CDC42EP1	2.02e-05	199	95	7	668_DN
Drug	lanthanum	CACNA1A CACNA1C DGCR2 CACNA1F ABI1 CACNA1G	2.29e-05	136	95	6	CID000023926
Drug	pentasulfane	CACNA1A SYNM CACNA1G	3.79e-05	16	95	3	CID000448216
Drug	KW-3049	CACNA1A CACNA1C CACNA1F CACNA1G	5.65e-05	50	95	4	CID000002324
Drug	nitrendipine	CACNA1A CACNA1C CACNA1F CACNA1G SLC30A4	5.69e-05	98	95	5	CID000004507
Drug	Cinildipine	CACNA1A CACNA1C CACNA1F CACNA1G	8.85e-05	56	95	4	CID000002752
Disease	Timothy syndrome (implicated_via_orthology)	CACNA1C CACNA1F	5.75e-05	4	92	2	DOID:0060173 (implicated_via_orthology)
Disease	methylcobalamin deficiency type cblE, cytotoxicity measurement	CHSY3 BOD1L1	1.43e-04	6	92	2	EFO_0006952, MONDO_0009354
Disease	Cornelia De Lange Syndrome	SETD5 NIPBL	2.66e-04	8	92	2	C0270972
Disease	Williams-Beuren syndrome (is_implicated_in)	EIF4H DNAJC30	3.41e-04	9	92	2	DOID:1928 (is_implicated_in)
Disease	Alzheimer disease, polygenic risk score	TCF20 MARK4 ASCC2 CHSY3 SYBU SIT1 HYDIN CSTPP1	4.98e-04	586	92	8	EFO_0030082, MONDO_0004975
Disease	severe acute respiratory syndrome, COVID-19	GLDC SAMD5 RIMBP2 CHSY3 PGM2 CCDC85A TBL1X	5.06e-04	447	92	7	EFO_0000694, MONDO_0100096
Disease	Intellectual Disability	SOX4 RABL6 BRF1 TCF20 BRSK2 CACNA1G WDR62	5.06e-04	447	92	7	C3714756
Disease	X-Linked Csnb	CACNA1F GPR179	6.22e-04	12	92	2	C3711543
Disease	Night blindness, congenital stationary, type 1	CACNA1F GPR179	6.22e-04	12	92	2	C3501847
Disease	Night Blindness, Congenital Stationary, Type 1A	CACNA1F GPR179	6.22e-04	12	92	2	C3495587
Disease	NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2B (disorder)	CACNA1F GPR179	6.22e-04	12	92	2	C1864877
Disease	NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2A	CACNA1F GPR179	6.22e-04	12	92	2	C1848172
Disease	NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1B	CACNA1F GPR179	6.22e-04	12	92	2	C1850362
Disease	Cone-rod synaptic disorder, congenital nonprogressive	CACNA1F GPR179	7.33e-04	13	92	2	C4041558
Disease	phosphatidylcholine 38:6 measurement	DEPDC5 CPOX	1.12e-03	16	92	2	EFO_0010388
Disease	Night blindness, congenital stationary	CACNA1F GPR179	1.27e-03	17	92	2	C0339535
Disease	immature granulocyte count	MARK4 DEPDC5	1.27e-03	17	92	2	EFO_0803542
Disease	brain connectivity measurement	SH3KBP1 BRSK2 TRIOBP PCDH7 KIAA1614 ARL17A	1.60e-03	400	92	6	EFO_0005210
Disease	hepatitis B (is_marker_for)	MAP4K4 FOXP3	1.94e-03	21	92	2	DOID:2043 (is_marker_for)
Disease	lung adenocarcinoma (is_marker_for)	SOX4 CD44 MAP4K4	2.41e-03	85	92	3	DOID:3910 (is_marker_for)
Disease	psychosis predisposition measurement	CACNA1C CD44	2.98e-03	26	92	2	EFO_0008337
Disease	cortical surface area measurement	CACNA1A DCHS2 ABI1 MYCBP2 BRSK2 LINC00574 TRIOBP SYBU MAP4K4 PCDH7 KIAA1614	3.09e-03	1345	92	11	EFO_0010736

Protein segments in the cluster

Peptide	Gene	Start	Entry
RAAGLQSQHAPGSGR	nan	111	Q9HAA7
ESRSGSPRTGADGEH	CACNA1A	941	O00555
GTRGPGASVHDRNAN	BAG6	116	P46379
SSTAVAGSPRGHGQS	ASCC2	706	Q9H1I8
EASSSQSFGLGPHRG	CPXM1	131	Q96SM3
SLNQRPRTHSGSSGG	ABI1	231	Q8IZP0
PRTHSGSSGGSGSRE	ABI1	236	Q8IZP0
STASGHDRPTRGAAA	BAG1	51	Q99933
DGGSCHRRGAPTGST	GATB	21	O75879
PHSSRCAGSGGQLDS	ARL17A	126	Q8IVW1
GSSREQSRDGSRHPG	FLG	1296	P20930
GQTAPSTGGRQGSRH	FLG	1456	P20930
GRSDASHGQSGPRSA	FLG	1526	P20930
ESAHGRTGPSTGGRQ	FLG	1776	P20930
QESARGRSGETSGHS	FLG	2721	P20930
GPSTRGRQGSRHEQA	FLG	2756	P20930
ESARGRSGETSGHSG	FLG	3046	P20930
SRHSQSGQGQSAGPR	FLG	3516	P20930
VRDSGHRGSSGSQAS	FLG	3651	P20930
ESAHGRAGPSTGGRQ	FLG	3721	P20930
SREQSRDGSRHPGSS	FLG	3891	P20930
TRPGSRARGNSSSNH	RTN4RL2	316	Q86UN3
RGTGDANHRASSGRS	RBM15B	71	Q8NDT2
EARSRGHASPLAANG	RABL6	276	Q3YEC7
PQAGSNTHRRGSGAL	CACNA1F	1711	O60840
QRDSSAPGRFHVGSA	DEPDC5	566	O75140
HRVESGGPGTSAASA	MMTAG2	151	Q9BU76
RGGSLDPSHSSGRGS	DCHS1	3021	Q96JQ0
GSHPGSQSGSGERFR	MAP4K4	691	O95819
SRGSAGGHGSRSQKE	EIF4H	21	Q15056
STQSTRGGHADNGRD	LRP12	696	Q9Y561
PGGVATTAAAGSRHS	NFXL1	51	Q6ZNB6
QGRDLRGGAHASSSS	FOXP3	46	Q9BZS1
GPRAAGTDGSDFQHR	JAGN1	6	Q8N5M9
ASGGGAGALSSAPHR	FAM149A	576	A5PLN7
ARQHSRDSGSPGHGS	GPR179	731	Q6PRD1
TAATAALAGRSGGPH	ATRN	16	O75882
NAASGSGPSARGRSA	HERC1	2861	Q15751
RTGSGSGGHVLSRAS	KIAA1614	961	Q5VZ46
HGQRSRSISGASSGL	BRSK2	406	Q8IWQ3
SSSNTGSGPRRGAHQ	PER3	751	P56645
SGGESRRAGAADSAP	PCDH7	191	O60245
RGSLGHPTAANSSDA	FAM214B	266	Q7L5A3
QQGSGSGQSPSRGRH	HRNR	651	Q86YZ3
SGQSPSRGRHGSDFG	HRNR	656	Q86YZ3
GSGHSPSRVRHGSSS	HRNR	771	Q86YZ3
GSRSGQSSRGERHGS	HRNR	1431	Q86YZ3
QQGSGSGQSPSRGRH	HRNR	1821	Q86YZ3
QQGSGSGQSPSRGRH	HRNR	2291	Q86YZ3
GSRSGQSSRGERHGS	HRNR	2371	Q86YZ3
SGHSHEGRRSSGGGR	NIPBL	1131	Q6KC79
DARAHPSSGGSSRRF	PGM2	106	Q96G03
PQSGSRSGFDHLSLG	EXPH5	1621	Q8NEV8
SGRSAGSHPGTRSVS	FAM83A	336	Q86UY5
SREQGHAPGGTSQAR	IGF2BP2	176	Q9Y6M1
SGEHQRPSRSGGGET	PCDH10	696	Q9P2E7
GGSSSHNRPSGSNVD	HUWE1	3156	Q7Z6Z7
ARPSGRSGHNTRGTG	CSNK1G3	16	Q9Y6M4
PSQESIGARSRGSGH	CASKIN2	696	Q8WXE0
TPHGRSGSSGARTQR	DCHS2	31	Q6V1P9
SGPAHDERTNGSGSG	FBXO38	826	Q6PIJ6
SNGGGQRSRSHSRSA	PAF1	486	Q8N7H5
AGSGSAPSVLHQRNG	BOD1L1	1486	Q8NFC6
SGHQRNPELRGSSGG	HYDIN	3961	Q4G0P3
GAPGRQFHGSASSLV	CACNA1C	2106	Q13936
TSSSGQHRQRPALGG	CSTPP1	176	Q9H6J7
PGLHRTASGRGSASE	CACNA1G	1181	O43497
TGGRRDPNHSEGSTT	CD44	541	P16070
GPFSELQNRGSRHSG	DNAJB2	121	P25686
LADSSGQGRSPAGAH	LINC00574	66	Q9H8X3
NHGGSSGSTHRSPRS	CDC42EP1	66	Q00587
RSGSSPEHARHSGGS	CCDC85A	321	Q96PX6
AAEALPGGGRHSRSS	DGCR2	531	P98153
SSHRESPRGSGGAEA	MBLAC1	56	A4D2B0
NDRNSDTHGTLGSGR	MARK4	11	Q96L34
LRSHESNAPGSAGGQ	MIDEAS	986	Q6PJG2
GELSHDSASPGRSAR	EMILIN3	486	Q9NT22
LSNPSSGSRTAGGAH	EVC	831	P57679
RTHDGSRASPGANRT	DNAJC30	146	Q96LL9
HRSPSGAGEGASCSD	GPRIN1	71	Q7Z2K8
SPRAAPARAGHNGNS	SCUBE3	451	Q8IX30
GTSEGTSAGSHPRAA	SLC20A2	296	Q08357
TEQSRGLGHGSTSRG	CPOX	56	P36551
PQAHSSASGGIRRSS	CAMSAP2	401	Q08AD1
AGSSRPGSARGEAVH	INVS	806	Q9Y283
SDQDSHSGSSGRGPG	FAM83G	591	A6ND36
EDGGRRRPSGTSHNA	RIMBP2	771	O15034
ASSPAAGRSPADHRG	SOX4	346	Q06945
PHRAGAPGSRAANAS	TMEM200B	76	Q69YZ2
HRGSQTGTSIGGDAR	SYNM	381	O15061
EVAGGASHSSGQRTP	SYNM	1081	O15061
GPAQGTRGDSRGHTT	SAMD5	101	Q5TGI4
AGHRANSPSLFGTEG	SH3KBP1	581	Q96B97
HSVRGAPPGNRSSAS	SLTM	911	Q9NWH9
GAHGVQGSSARTPSS	SETD5	1111	Q9C0A6
GSSGHLQSPGAQRDA	MRGPRG-AS1	111	Q2M3A8
RVSGPSSDCGSHGQA	MYCBP2	1336	O75592
GSGNSSQPSLREGHD	SPTY2D1	291	Q68D10
AQCSSGGRTHSPGRA	TRIOBP	1291	Q9H2D6
AAGQRRDGRPGSSHN	CHSY3	141	Q70JA7
RRLSSAHNGGSAFGA	PKP3	131	Q9Y446
GGSHFINTSSPRGEA	TBL1X	36	O60907
SFPLGDSRSHSQGEG	TEX13D	301	A0A0J9YY54
SPRGSCLESGGHSND	nan	246	Q6ZSR9
QQGASSGHTDPAGTR	SPIDR	501	Q14159
RNRGPHGRSNGASSH	SYBU	176	Q9NX95
RARDGHSASGPSSPA	SIGLEC1	576	Q9BZZ2
GQSGHSAAGPGFTSR	TCF20	681	Q9UGU0
LSSAGGGSPHREDAQ	BRF1	546	Q92994
SPDGQHLASGDRSGN	WDR62	501	O43379
PQGHDSRSRNSSGSP	ULK2	496	Q8IYT8
SNSPTRGSGCERNHG	SLC30A4	251	O14863
GGSSNHSASPSPRGA	SLC46A2	51	Q9BY10
NHGGDPLGSRASSTT	ZBTB49	721	Q6ZSB9
ARASTGSSDSSPGGH	TNFRSF1B	361	P20333
GDGGRAGTRSTAHTN	PTPRH	336	Q9HD43
SRSHPGQGRSGESVE	SIT1	71	Q9Y3P8
APRSRDSSSGGGDSA	GLDC	31	P23378