Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	positive regulation of ovulation	INHBA INHBB	1.20e-05	2	72	2	GO:0060279
GeneOntologyBiologicalProcess	regulation of ovulation	INHBA INHBB	3.60e-05	3	72	2	GO:0060278
GeneOntologyCellularComponent	FHF complex	HOOK2 FHIP1B	1.13e-04	5	71	2	GO:0070695
Domain	GSK3-bd	FRAT1 FRAT2	1.55e-05	2	74	2	IPR008014
Domain	GSK-3_bind	FRAT1 FRAT2	1.55e-05	2	74	2	PF05350
Domain	TGFb_propeptide	GDF7 INHBA INHBB	1.82e-04	28	74	3	PF00688
Domain	TGF-b_N	GDF7 INHBA INHBB	1.82e-04	28	74	3	IPR001111
Domain	BRK	CHD8 CHD6	2.30e-04	6	74	2	SM00592
Domain	HOOK	HOOK2 CCDC88B	2.30e-04	6	74	2	PF05622
Domain	Hook-related_fam	HOOK2 CCDC88B	2.30e-04	6	74	2	IPR008636
Domain	BRK_domain	CHD8 CHD6	2.30e-04	6	74	2	IPR006576
Domain	BRK	CHD8 CHD6	2.30e-04	6	74	2	PF07533
Domain	TGF-beta-rel	GDF7 INHBA INHBB	2.73e-04	32	74	3	IPR015615
Domain	TGFb_CS	GDF7 INHBA INHBB	2.73e-04	32	74	3	IPR017948
Domain	-	MPP3 CNKSR1 SYNPO2L TJP2 PARD6G	3.22e-04	150	74	5	2.30.42.10
Domain	PDZ	MPP3 CNKSR1 SYNPO2L TJP2 PARD6G	3.32e-04	151	74	5	PS50106
Domain	PDZ	MPP3 CNKSR1 SYNPO2L TJP2 PARD6G	3.43e-04	152	74	5	IPR001478
Domain	TGFB	GDF7 INHBA INHBB	4.21e-04	37	74	3	SM00204
Domain	TGF-b_C	GDF7 INHBA INHBB	4.21e-04	37	74	3	IPR001839
Domain	TGF_BETA_2	GDF7 INHBA INHBB	4.21e-04	37	74	3	PS51362
Domain	TGF_beta	GDF7 INHBA INHBB	4.21e-04	37	74	3	PF00019
Domain	TGF_BETA_1	GDF7 INHBA INHBB	4.21e-04	37	74	3	PS00250
Domain	-	BAZ2A MBD1	4.27e-04	8	74	2	3.30.890.10
Domain	Integrin_bsu	ITGBL1 ITGB7	5.48e-04	9	74	2	IPR015812
Domain	INTEGRIN_BETA	ITGBL1 ITGB7	5.48e-04	9	74	2	PS00243
Domain	PSI	SEMA3B ITGB7 SEMA4G	7.04e-04	44	74	3	IPR016201
Domain	PSI	SEMA3B ITGB7 SEMA4G	8.02e-04	46	74	3	SM00423
Domain	Methyl_CpG_DNA-bd	BAZ2A MBD1	8.32e-04	11	74	2	IPR001739
Domain	MBD	BAZ2A MBD1	8.32e-04	11	74	2	PF01429
Domain	DNA-bd_dom	BAZ2A MBD1	8.32e-04	11	74	2	IPR016177
Domain	MBD	BAZ2A MBD1	8.32e-04	11	74	2	SM00391
Domain	MBD	BAZ2A MBD1	8.32e-04	11	74	2	PS50982
Domain	Inhibin_asu	INHBA INHBB	1.17e-03	13	74	2	IPR002405
Domain	EGF_extracell	ITGBL1 NAGPA ITGB7	1.74e-03	60	74	3	IPR013111
Domain	EGF_2	ITGBL1 NAGPA ITGB7	1.74e-03	60	74	3	PF07974
Domain	Myosin_tail_1	MYH7B CCDC102A	2.27e-03	18	74	2	PF01576
Domain	Myosin_tail	MYH7B CCDC102A	2.27e-03	18	74	2	IPR002928
Domain	PDZ	MPP3 SYNPO2L TJP2 PARD6G	2.38e-03	141	74	4	PF00595
Domain	-	GDF7 INHBA INHBB	2.38e-03	67	74	3	2.10.90.10
Domain	Cystine-knot_cytokine	GDF7 INHBA INHBB	2.38e-03	67	74	3	IPR029034
Domain	Semaphorin	SEMA3B SEMA4G	2.81e-03	20	74	2	IPR027231
Domain	PDZ	MPP3 SYNPO2L TJP2 PARD6G	2.83e-03	148	74	4	SM00228
Domain	GUANYLATE_KINASE_2	MPP3 TJP2	3.71e-03	23	74	2	PS50052
Domain	GUANYLATE_KINASE_1	MPP3 TJP2	3.71e-03	23	74	2	PS00856
Domain	Chromo_domain	CHD8 CHD6	4.04e-03	24	74	2	IPR023780
Domain	JmjC	KDM5C HR	4.04e-03	24	74	2	PF02373
Domain	Ricin_B_lectin	GALNT12 GALNT16	4.38e-03	25	74	2	PF00652
Domain	Guanylate_kin	MPP3 TJP2	4.73e-03	26	74	2	PF00625
Domain	GK/Ca_channel_bsu	MPP3 TJP2	4.73e-03	26	74	2	IPR008145
Domain	Guanylate_kin-like_dom	MPP3 TJP2	4.73e-03	26	74	2	IPR008144
Domain	Chromo	CHD8 CHD6	4.73e-03	26	74	2	PF00385
Domain	GuKc	MPP3 TJP2	4.73e-03	26	74	2	SM00072
Domain	RICIN	GALNT12 GALNT16	5.48e-03	28	74	2	SM00458
Domain	CHROMO_1	CHD8 CHD6	5.48e-03	28	74	2	PS00598
Domain	CHROMO_2	CHD8 CHD6	5.48e-03	28	74	2	PS50013
Domain	RICIN_B_LECTIN	GALNT12 GALNT16	5.48e-03	28	74	2	PS50231
Domain	Ricin_B_lectin	GALNT12 GALNT16	6.27e-03	30	74	2	IPR000772
Domain	Glycos_transf_2	GALNT12 GALNT16	6.27e-03	30	74	2	PF00535
Domain	Glyco_trans_2-like	GALNT12 GALNT16	6.27e-03	30	74	2	IPR001173
Domain	Sema	SEMA3B SEMA4G	6.69e-03	31	74	2	SM00630
Domain	Semap_dom	SEMA3B SEMA4G	6.69e-03	31	74	2	IPR001627
Domain	HMGI/Y_DNA-bd_CS	BAZ2A YTHDC1	6.69e-03	31	74	2	IPR000637
Domain	Sema	SEMA3B SEMA4G	6.69e-03	31	74	2	PF01403
Domain	SEMA	SEMA3B SEMA4G	6.69e-03	31	74	2	PS51004
Pubmed	Human granulosa-lutein cell in vitro production of progesterone, inhibin A, inhibin B, and activin A are dependent on follicular size and not the presence of the oocyte.	INHBA INHBB	4.71e-06	2	76	2	17681301
Pubmed	Elevated expression of activins promotes muscle wasting and cachexia.	INHBA INHBB	4.71e-06	2	76	2	24378873
Pubmed	The RNA Binding Proteins YTHDC1 and FMRP Regulate the Nuclear Export of N6-Methyladenosine-Modified Hepatitis B Virus Transcripts and Affect the Viral Life Cycle.	FMR1 YTHDC1	4.71e-06	2	76	2	33883220
Pubmed	Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions.	INHBA INHBB	4.71e-06	2	76	2	10932194
Pubmed	Activins are critical modulators of growth and survival.	INHBA INHBB	4.71e-06	2	76	2	14551263
Pubmed	Immunolabeling of the inhibin-βA and -βB subunit in normal and malignant human cervical tissue and cervical cancer cell lines.	INHBA INHBB	4.71e-06	2	76	2	21475087
Pubmed	Production of activins by the human endosalpinx.	INHBA INHBB	4.71e-06	2	76	2	12414903
Pubmed	Involvement of FMRP in Primary MicroRNA Processing via Enhancing Drosha Translation.	FMR1 DROSHA	4.71e-06	2	76	2	26993298
Pubmed	Inhibins and activins regulate mammary epithelial cell differentiation through mesenchymal-epithelial interactions.	INHBA INHBB	4.71e-06	2	76	2	9226441
Pubmed	The Activin/FLRG Pathway Associates with Poor COVID-19 Outcomes in Hospitalized Patients.	INHBA INHBB	4.71e-06	2	76	2	34723652
Pubmed	Inhibins differentially antagonize activin and bone morphogenetic protein action in a mouse adrenocortical cell line.	INHBA INHBB	4.71e-06	2	76	2	16601134
Pubmed	Clinical application value of Inhibin B alone or in combination with other hormone indicators in subfertile men with different spermatogenesis status: A study of 324 Chinese men.	INHBA INHBB	4.71e-06	2	76	2	34181290
Pubmed	Human and mouse activin genes: Divergent expression of activin A protein variants and identification of a novel heparan sulfate-binding domain in activin B.	INHBA INHBB	4.71e-06	2	76	2	32074129
Pubmed	Activin promotes differentiation of cultured mouse trophoblast stem cells towards a labyrinth cell fate.	INHBA INHBB KDM5C	6.67e-06	17	76	3	19716815
Pubmed	Localization of activin subunits in early murine development determined by subunit-specific antibodies.	INHBA INHBB	1.41e-05	3	76	2	8133077
Pubmed	Serum inhibin A, inhibin B, pro-alphaC, and activin A levels in women with idiopathic premature ovarian failure.	INHBA INHBB	1.41e-05	3	76	2	15374731
Pubmed	Strong induction of activin expression after injury suggests an important role of activin in wound repair.	INHBA INHBB	1.41e-05	3	76	2	8606007
Pubmed	Frat is a phosphatidylinositol 3-kinase/Akt-regulated determinant of glycogen synthase kinase 3β subcellular localization in pluripotent cells.	FRAT1 FRAT2	1.41e-05	3	76	2	22064483
Pubmed	The role of activin a in regulation of hemopoiesis.	INHBA INHBB	1.41e-05	3	76	2	12456957
Pubmed	Functional analysis of activins during mammalian development.	INHBA INHBB	1.41e-05	3	76	2	7885473
Pubmed	Activin B: precursor sequences, genomic structure and in vitro activities.	INHBA INHBB	1.41e-05	3	76	2	2575216
Pubmed	Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2.	FRAT1 FRAT2	1.41e-05	3	76	2	12095675
Pubmed	A novel role of activin in inflammation and repair.	INHBA INHBB	1.41e-05	3	76	2	10320815
Pubmed	Proteomic identification and functional validation of activins and bone morphogenetic protein 11 as candidate novel muscle mass regulators.	INHBA INHBB	1.41e-05	3	76	2	18927237
Pubmed	High serum concentration of total inhibin in polycystic ovary syndrome.	INHBA INHBB	1.41e-05	3	76	2	18423626
Pubmed	Inhibin: definition and nomenclature, including related substances.	INHBA INHBB	1.41e-05	3	76	2	3345731
Pubmed	Structure of two human ovarian inhibins.	INHBA INHBB	1.41e-05	3	76	2	3754442
Pubmed	Implication of inhibin and related proteins in fetal development.	INHBA INHBB	1.41e-05	3	76	2	8606941
Pubmed	Activins are expressed in preimplantation mouse embryos and in ES and EC cells and are regulated on their differentiation.	INHBA INHBB	1.41e-05	3	76	2	8330535
Pubmed	Inhibin/activin subunits beta-A (-betaA) and beta-B (-betaB) are differentially localised in normal, hyperplastic and malignant human endometrial tissue.	INHBA INHBB	1.41e-05	3	76	2	16423381
Pubmed	Complex expression patterns support potential roles for maternally derived activins in the establishment of pregnancy in mouse.	INHBA INHBB	1.41e-05	3	76	2	17071781
Pubmed	Overexpression of activin-A and -B in malignant mesothelioma - attenuated Smad3 signaling responses and ERK activation promote cell migration and invasive growth.	INHBA INHBB	1.41e-05	3	76	2	25557874
Pubmed	Intraovarian activins are required for female fertility.	INHBA INHBB	1.41e-05	3	76	2	17609433
Pubmed	The ATP-dependent chromatin remodeling enzymes CHD6, CHD7, and CHD8 exhibit distinct nucleosome binding and remodeling activities.	CHD8 CHD6	1.41e-05	3	76	2	28533432
Pubmed	Mutational analysis of the mature peptide region of inhibin genes in Indian women with ovarian failure.	INHBA INHBB	1.41e-05	3	76	2	15205401
Pubmed	Inhibin/activin betaB-subunit expression in pheochromocytomas favors benign diagnosis.	INHBA INHBB	1.41e-05	3	76	2	11344232
Pubmed	Characterization and functional analysis of the murine Frat2 gene.	FRAT1 FRAT2	1.41e-05	3	76	2	15073180
Pubmed	Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene U2af1.	U2AF1 NDOR1	1.41e-05	3	76	2	30322915
Pubmed	Crystal structure of a dimerization domain of human Caprin-1: insights into the assembly of an evolutionarily conserved ribonucleoprotein complex consisting of Caprin-1, FMRP and G3BP1.	FMR1 G3BP1	1.41e-05	3	76	2	27303792
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	CNKSR1 RNF169 KDM5C TJP2 CHD8 YTHDC1 CTU1 ZNF574	1.44e-05	503	76	8	16964243
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	BAZ2A KDM5C MBD1 CHD8 CHD6	2.51e-05	157	76	5	30186101
Pubmed	Constitutive and ghrelin-dependent GHSR1a activation impairs CaV2.1 and CaV2.2 currents in hypothalamic neurons.	GHSR CACNA1B	2.82e-05	4	76	2	26283199
Pubmed	Localization of activin beta(A)-, beta(B)-, and beta(C)-subunits in humanprostate and evidence for formation of new activin heterodimers of beta(C)-subunit.	INHBA INHBB	2.82e-05	4	76	2	11134153
Pubmed	Serum inhibin A and inhibin B levels in epithelial ovarian cancer patients.	INHBA INHBB	2.82e-05	4	76	2	24599287
Pubmed	Inhibin secretion in women with the polycystic ovary syndrome before and after treatment with progesterone.	INHBA INHBB	2.82e-05	4	76	2	21529351
Pubmed	The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation.	FRAT1 FRAT2	2.82e-05	4	76	2	11738041
Pubmed	Molecular cloning of the mouse activin beta E subunit gene.	INHBA INHBB	2.82e-05	4	76	2	8941337
Pubmed	Role of PCSK5 expression in mouse ovarian follicle development: identification of the inhibin α- and β-subunits as candidate substrates.	INHBA INHBB	2.82e-05	4	76	2	21408162
Pubmed	Effects of recombinant activins on steroidogenesis in human granulosa-lutein cells.	INHBA INHBB	2.82e-05	4	76	2	25062451
Pubmed	Hyperglycemia is associated with reduced testicular function and activin dysregulation in the Ins2Akita+/- mouse model of type 1 diabetes.	INHBA INHBB	2.82e-05	4	76	2	28214591
Pubmed	The miR-3648/FRAT1-FRAT2/c-Myc negative feedback loop modulates the metastasis and invasion of gastric cancer cells.	FRAT1 FRAT2	2.82e-05	4	76	2	36153370
Pubmed	Activin B regulates islet composition and islet mass but not whole body glucose homeostasis or insulin sensitivity.	INHBA INHBB	2.82e-05	4	76	2	22739106
Pubmed	Stimulation of activin receptor II signaling pathways inhibits differentiation of multiple gastric epithelial lineages.	INHBA INHBB	2.82e-05	4	76	2	9482661
Pubmed	BMPR2 inhibits activin and BMP signaling via wild-type ALK2.	INHBA INHBB	2.82e-05	4	76	2	29739878
Pubmed	Gonadotropin-dependent and gonadotropin-independent development of inhibin subunit messenger ribonucleic acid levels in the mouse ovary.	INHBA INHBB	2.82e-05	4	76	2	7720655
Pubmed	Structural analysis of the mouse activin beta C gene.	INHBA INHBB	2.82e-05	4	76	2	8679697
Pubmed	SMAD2 and SMAD3 differentially regulate adiposity and the growth of subcutaneous white adipose tissue.	INHBA INHBB	2.82e-05	4	76	2	34731499
Pubmed	Retinoic Acid Antagonizes Testis Development in Mice.	INHBA INHBB RSPO1	2.82e-05	27	76	3	30067986
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	CACTIN FMR1 UBR5 BAZ2A DROSHA KDM5C MBD1 CHD8 TOPORS PLEKHN1 ZNF574	3.00e-05	1116	76	11	31753913
Pubmed	Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module.	GDF7 INHBA INHBB GPR132 ITGB7	4.45e-05	177	76	5	22560297
Pubmed	Differential expression of inhibin subunits and follistatin, but not of activin receptor type II, during early murine embryonic development.	INHBA INHBB	4.69e-05	5	76	2	1330789
Pubmed	Expression of activins and TGF beta 1 and beta 2 RNAs in early postimplantation mouse embryos and uterine decidua.	INHBA INHBB	4.69e-05	5	76	2	1373953
Pubmed	Expression cloning of an activin receptor, a predicted transmembrane serine kinase.	INHBA INHBB	4.69e-05	5	76	2	1646080
Pubmed	Linkage mapping of the angiotensin AT2 receptor gene (Agtr2) to the mouse X chromosome.	INHBA INHBB	4.69e-05	5	76	2	8586443
Pubmed	Differential binding and neutralization of activins A and B by follistatin and follistatin like-3 (FSTL-3/FSRP/FLRG).	INHBA INHBB	4.69e-05	5	76	2	12697670
Pubmed	Novel FMRP interaction networks linked to cellular stress.	FMR1 G3BP1	4.69e-05	5	76	2	32525608
Pubmed	Expression of inhibin subunits and follistatin during postimplantation mouse development: decidual expression of activin and expression of follistatin in primitive streak, somites and hindbrain.	INHBA INHBB	4.69e-05	5	76	2	7600958
Pubmed	Inhibin interferes with activin signaling at the level of the activin receptor complex in Chinese hamster ovary cells.	INHBA INHBB	4.69e-05	5	76	2	9202237
Pubmed	Expression and function of activin beta A during mouse cardiac cushion tissue formation.	INHBA INHBB	4.69e-05	5	76	2	9707328
Pubmed	Frat oncoproteins act at the crossroad of canonical and noncanonical Wnt-signaling pathways.	FRAT1 FRAT2	4.69e-05	5	76	2	19802005
Pubmed	Genes coding for mouse activin beta C and beta E are closely linked and exhibit a liver-specific expression pattern in adult tissues.	INHBA INHBB	4.69e-05	5	76	2	9070865
Pubmed	Bone morphogenetic protein-6 stimulates gene expression of follicle-stimulating hormone receptor, inhibin/activin beta subunits, and anti-Müllerian hormone in human granulosa cells.	INHBA INHBB	4.69e-05	5	76	2	19539911
Pubmed	Mapping of genes for inhibin subunits alpha, beta A, and beta B on human and mouse chromosomes and studies of jsd mice.	INHBA INHBB	4.69e-05	5	76	2	2767687
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	CACTIN RNF169 G3BP1 UBE4B BAZ2A KDM5C TJP2 TOPORS YTHDC1	4.81e-05	774	76	9	15302935
Pubmed	Genetic mouse models of autism spectrum disorder present subtle heterogenous cardiac abnormalities.	FMR1 CHD8	7.03e-05	6	76	2	35445787
Pubmed	Developmental expression of activin/inhibin beta A, beta B, and alpha subunits, and activin receptor-IIB genes in preimplantation mouse embryos.	INHBA INHBB	7.03e-05	6	76	2	8286599
Pubmed	Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome.	UBR5 MARCHF7	7.03e-05	6	76	2	25594175
Pubmed	Frat is dispensable for canonical Wnt signaling in mammals.	FRAT1 FRAT2	7.03e-05	6	76	2	15681612
Pubmed	Expression of activin subunits, activin receptors and follistatin in postimplantation mouse embryos suggests specific developmental functions for different activins.	INHBA INHBB	7.03e-05	6	76	2	7821227
Pubmed	Genetic variation in the inhibin pathway and risk of testicular germ cell tumors.	INHBA INHBB	7.03e-05	6	76	2	18413775
Pubmed	Sexually dimorphic regulation of inhibin beta B in establishing gonadal vasculature in mice.	INHBA INHBB	7.03e-05	6	76	2	16452457
Pubmed	Activin disrupts epithelial branching morphogenesis in developing glandular organs of the mouse.	INHBA INHBB	7.03e-05	6	76	2	7619733
Pubmed	Structure, chromosomal localization, and expression analysis of the mouse inhibin/activin beta C (Inhbc) gene.	INHBA INHBB	9.83e-05	7	76	2	8838799
Pubmed	Endogenous inhibins regulate steroidogenesis in mouse TM3 Leydig cells by altering SMAD2 signalling.	INHBA INHBB	9.83e-05	7	76	2	27465829
Pubmed	Regulation of muscle mass by follistatin and activins.	INHBA INHBB	9.83e-05	7	76	2	20810712
Pubmed	Effects of TGFbeta2 on wild-type and Tgfbr3 knockout mouse fetal testis.	INHBA INHBB	9.83e-05	7	76	2	23303681
Pubmed	A novel hook-related protein family and the characterization of hook-related protein 1.	HOOK2 CCDC88B	9.83e-05	7	76	2	15882442
Pubmed	Functional analysis of mammalian members of the transforming growth factor-beta superfamily.	INHBA INHBB	9.83e-05	7	76	2	18406693
Pubmed	Phosphorylation-dependent interaction of SATB1 and PIAS1 directs SUMO-regulated caspase cleavage of SATB1.	UBR5 TOPORS	1.31e-04	8	76	2	20351170
Pubmed	Localization of the inhibin beta B gene on mouse chromosome 1.	INHBA INHBB	1.31e-04	8	76	2	8358176
Pubmed	Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins.	FMR1 G3BP1	1.31e-04	8	76	2	25225333
Pubmed	A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea.	INHBA INHBB	1.31e-04	8	76	2	31187730
Pubmed	The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance.	INHBA INHBB	1.68e-04	9	76	2	14736745
Pubmed	A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment.	DROSHA MBD1	1.68e-04	9	76	2	18604195
Pubmed	Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.	KMT5A KDM5C HR	1.72e-04	49	76	3	34368113
Pubmed	Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia.	INHBA INHBB	2.10e-04	10	76	2	12651901
Pubmed	An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex.	HOOK2 FHIP1B	2.10e-04	10	76	2	18799622
Pubmed	Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP).	INHBA INHBB	2.10e-04	10	76	2	11266516
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	ITGBL1 FMR1 MBD1 NECAB3 IGSF9 HOOK2 CCDC88B	2.26e-04	560	76	7	21653829
Pubmed	TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population.	GDF7 INHBA INHBB	2.42e-04	55	76	3	15342483
GeneFamily	PDZ domain containing	MPP3 CNKSR1 SYNPO2L TJP2 PARD6G	7.43e-05	152	52	5	1220
GeneFamily	CD molecules\|Integrin beta subunits	ITGBL1 ITGB7	2.88e-04	9	52	2	1159
GeneFamily	Zinc fingers CXXC-type\|Methyl-CpG binding domain containing	BAZ2A MBD1	4.39e-04	11	52	2	1025
GeneFamily	Immunoglobulin like domain containing\|Semaphorins	SEMA3B SEMA4G	1.49e-03	20	52	2	736
GeneFamily	Polypeptide N-acetylgalactosaminyltransferases	GALNT12 GALNT16	1.49e-03	20	52	2	433
GeneFamily	Calcium voltage-gated channel subunits\|Membrane associated guanylate kinases	MPP3 TJP2	2.52e-03	26	52	2	904
ToppCell	Substantia_nigra-Macroglia-POLYDENDROCYTE-P1\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	KMT5A KIF19 RASSF10 MISP3 ITGB7	1.28e-06	110	76	5	bede775886b45cce4aa229baead0e800b5be25a8
ToppCell	Globus_pallidus-Macroglia-POLYDENDROCYTE-P1\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	KIF19 RASSF10 MISP3 ITGB7 MVD	3.78e-06	137	76	5	80f1a6cfb48ccfba1c3545fdcd5fcb3157272aca
ToppCell	Entopeduncular-Macroglia-POLYDENDROCYTE\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	KIF19 RASSF10 MISP3 ITGB7 MVD	5.16e-06	146	76	5	a317f14a1aab11ffcce65baeb1c475c04324315f
ToppCell	Thalamus-Macroglia-POLYDENDROCYTE-P1\|Thalamus / BrainAtlas - Mouse McCarroll V32	KMT5A KIF19 RASSF10 MISP3 ITGB7	5.33e-06	147	76	5	a21b63d0d3aec9ffadf3fac833a0a24da58a95bf
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Rorb-Excitatory_Neuron.Sc17a7.Rorb-BC006965_(Layer_5a,_BC006965+)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ZAR1L C2CD4B LRRC26 GPR132	1.13e-05	81	76	4	9de04f435b5acbfb1d709103db35e56e8ac97a85
ToppCell	Substantia_nigra-Macroglia-POLYDENDROCYTE-P1-P1_1-Tnr-Polydendrocyte.Tnr.Opalin_(Opalin)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	KMT5A RASSF10 MISP3 ITGB7	1.19e-05	82	76	4	5cd8e47edb775eabf3e9a407c1c2d8a78afb9509
ToppCell	Substantia_nigra-Macroglia-POLYDENDROCYTE-P1-P1_1-Tnr\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	KMT5A RASSF10 MISP3 ITGB7	1.19e-05	82	76	4	1eeb259ec555879ee1962b7bc2c31c200fbb85cf
ToppCell	facs-Skin-nan-24m-Mesenchymal\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGBL1 SEMA3B EFCC1 RSPO1 GALNT16	1.62e-05	185	76	5	8433a337625ff8398520e223ef92bf9bb0beb14c
ToppCell	facs-Skin-nan-24m-Mesenchymal-fibroblast\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGBL1 SEMA3B EFCC1 RSPO1 GALNT16	1.62e-05	185	76	5	049d793d043d5d434f143025de49dd210d18756c
ToppCell	facs-Skin-nan-24m-Mesenchymal-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGBL1 SEMA3B EFCC1 RSPO1 GALNT16	1.62e-05	185	76	5	63200c42565eea596f9b00728e70e544b8d50a7f
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P1-P1_2\|Hippocampus / BrainAtlas - Mouse McCarroll V32	P2RY2 KIF19 RASSF10 ITGB7	1.80e-05	91	76	4	83564e9e4122c176a28c30b0c2546c82185ddaa6
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P1-P1_2-Tnr\|Hippocampus / BrainAtlas - Mouse McCarroll V32	P2RY2 KIF19 RASSF10 ITGB7	1.80e-05	91	76	4	ff6022b23e9bd8af24bcb658ae2b48eae6bf1e28
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P1-P1_2-Tnr-Polydendrocyte.Tnr.Pdgfa_(Pdgfa)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	P2RY2 KIF19 RASSF10 ITGB7	1.80e-05	91	76	4	4d84281e8e3236c687b910cd76de836b70dafdb7
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)\|390C / Donor, Lineage, Cell class and subclass (all cells)	CACTIN CNKSR1 NRL UBR5 SEMA3B	2.04e-05	194	76	5	88db9f9e80c20ff3474f1f6459dcbdc25aec0b6d
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	CACTIN CNKSR1 NRL UBR5 SEMA3B	2.04e-05	194	76	5	a71728202493d4858342ea2756ea281cd0d99a3a
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P1-P1_1-Trf-Oligodendrocyte.Tfr.Tmem2_(Tmem2)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	KIF19 RASSF10 MISP3 ITGB7	2.93e-05	103	76	4	287e945ef2f9646f1ff4a4c50fe6e8a5e7fe0d92
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P1\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	KIF19 RASSF10 MISP3 ITGB7	3.04e-05	104	76	4	30b2f6f6612ea45c92f0d466e301d85291a2ee70
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P1-P1_1\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	KIF19 RASSF10 MISP3 ITGB7	3.04e-05	104	76	4	a0e03cc97d453050c6b7e6e290ef0babc7bc1276
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P1-P1_1-Trf\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	KIF19 RASSF10 MISP3 ITGB7	3.04e-05	104	76	4	3cc15f0abdf1f4304af9152911a1f3aab3bc0925
ToppCell	TCGA-Head_and_Esophagus-Primary_Tumor-Head_and_Neck_Carcinoma-Squamous_Cell_Carcinoma_-_Basaloid_Type\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	MPP3 ZAR1L FRAT1 FRAT2	3.79e-05	110	76	4	f26c7d02e8931e91065deea2f3f51d452bc445da
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Rorb\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ZAR1L C2CD4B IGSF9 RSPO1	4.66e-05	116	76	4	9c92e714e210a2f29a9e228653d4c990ec643c72
ToppCell	Frontal_cortex-Macroglia-POLYDENDROCYTE-P1\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	KMT5A KIF19 MISP3 ITGB7	4.82e-05	117	76	4	13f068cc4b4a8e9c66bf0e9e5acf9613654bf3f4
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6-Excitatory_Neuron.Slc17a7.Syt6-Slc24a2_(Deep_layer_pyramidal_cells)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SPTBN5 LRRC26 ZNF853	5.84e-05	44	76	3	405ac4aeee539322cfe661c7531248f81271be8d
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6-Excitatory_Neuron.Slc17a7.Syt6-Slc24a2_(Deep_layer_pyramidal_cells)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SPTBN5 LRRC26 ZNF853	5.84e-05	44	76	3	a2c99e8ca635590a1f167b68bc390e2aa01e26be
ToppCell	LV-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	MPP3 MYH7B HOOK2 ITGB7	7.27e-05	130	76	4	a3e12984fb61311e49cc76c59f74f4dffc48faa1
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Tmem163_Dmrtb1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ZAR1L C2CD4B INHBB KCNG1	8.66e-05	136	76	4	0376c2907b869c7d42f57af7f65ffdd6246c4d27
Disease	autism spectrum disorder (implicated_via_orthology)	FMR1 KDM5C CHD8 CHD6 CHRNB2	3.60e-05	152	72	5	DOID:0060041 (implicated_via_orthology)
Disease	CHARGE syndrome (implicated_via_orthology)	CHD8 CHD6	1.22e-04	7	72	2	DOID:0050834 (implicated_via_orthology)
Disease	Facies	FMR1 CHD8	2.61e-04	10	72	2	C0282631
Disease	Mental Retardation, Psychosocial	CNKSR1 FMR1 KDM5C CHD8	3.78e-04	139	72	4	C0025363
Disease	Profound Mental Retardation	CNKSR1 FMR1 KDM5C CHD8	3.78e-04	139	72	4	C0020796
Disease	Mental deficiency	CNKSR1 FMR1 KDM5C CHD8	3.78e-04	139	72	4	C0917816
Disease	Autistic Disorder	FMR1 KDM5C CHD8 CHRNB2	3.84e-03	261	72	4	C0004352
Disease	hair colour measurement	SPATA2L INHBA INHBB MYH7B KMT5A MVD	3.91e-03	615	72	6	EFO_0007822
Disease	Intellectual Disability	CACNA1B CNKSR1 FMR1 KDM5C CHD8	4.75e-03	447	72	5	C3714756

Protein segments in the cluster

Peptide	Gene	Start	Entry
FARRGAGRRRREIKA	nan	26	Q9H8V8
RASEVLRRGTGRRRD	FAM246C	16	P0DSO1
RRVCVGGKRRRDDIS	PPP2R2C	391	Q9Y2T4
KIEAAERGDRRRRRC	CHD8	1766	Q9HCK8
ERGDRRRRRCEAAFK	CHD8	1771	Q9HCK8
RRLPSRRREDFRRCL	LINC00242	21	Q5T6M2
AGRLPRLQEELRRCR	CCDC88B	326	A6NC98
RGELRGRLARLELER	CCDC88B	1186	A6NC98
GDGRRRRVLLRGRES	BAZ2A	1756	Q9UIF9
RGDRERLGSRLRALR	BAG1	11	Q99933
TGCRRERERRQERGR	CACNA1B	2096	Q00975
AGRLRRGQAEVRRRA	EFCC1	271	Q9HA90
DRREGLIRSRVRGAD	GALNT16	186	Q8N428
RRRRRGLECDGKVNI	INHBA	306	P08476
LEDGCRRRRRQRRSR	RASSF10	36	A6NK89
REARRGVDRCVRACR	FHIP1B	556	Q8N612
AGQRRRRLGRRARCH	KMT5A	26	Q9NQR1
SCRRRLGELRELRRQ	HOOK2	316	Q96ED9
RHRIRKRGLECDGRT	INHBB	286	P09529
RALRAGRSRRLARVR	C2CD4B	186	A6NLJ0
GLGDRLCRLLRRERE	HR	561	O43593
ERRRCLRIVERSRGC	MBD1	211	Q9UIS9
EGCRKREAELGRLRR	MYH7B	1211	A7E2Y1
RRGVGRRLLAFAEAR	NAT14	136	Q8WUY8
GCGRDEALRLKQRRR	NRL	151	P54845
IRCLARKRRNSRDGD	MVD	86	P53602
EGEGRLGRCMRRLRD	KCNG1	201	Q9UIX4
PARRRLGLRRSDRTD	P2RY2	331	P41231
SERLGREARRRRLGC	NDOR1	21	Q9UHB4
REARRRRLGCRVQAL	NDOR1	26	Q9UHB4
LCRRRRALGALRDEG	PARD6G	111	Q9BYG4
EARRCARREELLARG	ITGB7	76	P26010
ALEQRCRELRARGRR	KIF19	531	Q2TAC6
ERESFLRRGDGRRRG	FMR1	521	Q06787
RARCRRALRRFFARG	GFRA4	61	Q9GZZ7
RRRRGDAVVGASLRD	GHSR	241	Q92847
SLRRDDAATRRRRGR	CHD6	2276	Q8TD26
RAAREGDRRDNRLRG	G3BP1	416	Q13283
RRRALEEGARRVGAT	CTU1	151	Q7Z7A3
EARGRELARLRGARG	CCDC102A	151	Q96A19
ARRRCPRELRRGREA	GALNT12	6	Q8IXK2
AEERARVLDRRGCSR	ANKRD9	141	Q96BM1
RNRCTPLFSRRRREG	MARCHF7	391	Q9H992
LRCALGDRGRVRGRA	FRAT1	111	Q92837
GLRQRVRRGRSRADL	KLF13	146	Q9Y2Y9
SHGRRNRRRREDEGR	CACTIN	31	Q8WUQ7
TNREACRDLSGRRLR	SDE2	96	Q6IQ49
RLSRAESERRCRAPG	ITGBL1	41	O95965
LRCALGDRGRVRGRA	FRAT2	111	O75474
VAGLRRSFRLGCRER	MPP3	336	Q13368
RGRRRRRTAILISAC	GPR132	151	Q9UNW8
IRRRSQAGRAGLRER	SYNPO2L	36	Q9H987
GERHRSLDRRERGRS	DROSHA	241	Q9NRR4
SLDRRERGRSPDRRR	DROSHA	246	Q9NRR4
RASIGRRRTELRRSG	PLEKHN1	391	Q494U1
RQCLERELRRGRAGV	SPATA2L	11	Q8IUW3
RGRQCRGIHRKARRC	SSPOP	1946	A2VEC9
RAVIGGRRRRRTALA	GDF7	311	Q7Z4P5
RLPRDCTRVRAGNRE	NAGPA	46	Q9UK23
CGFRRGSEERTRRVL	RSPO1	166	Q2MKA7
AAALSRRGRRGRCDE	RNF169	16	Q8NCN4
RRGRRGRCDETAAAK	RNF169	21	Q8NCN4
LTGARCERLRGRHGR	SPTBN5	3591	Q9NRC6
RERRRRLLEGLRGTA	PNMA6A	191	P0CW24
LRLRRRQREREGAGA	CHRNB2	361	P17787
LSRRRVSCRELGRPD	CNKSR1	391	Q969H4
RTRDRSRGRSLERGL	TJP2	211	Q9UDY2
LYVACLREGRRGRRR	SEMA4G	696	Q9NTN9
RSCEREESLRRSRGL	MISP3	11	Q96FF7
ARGLLLRRLRRRDSG	SEMA3B	626	Q13214
ADEIRRRRLARLAGG	UBE4B	6	O95155
GEAIGRDRRGRRARR	ZNF574	281	Q6ZN55
GGGRERDRRRSRDRE	U2AF1	221	Q01081
AGCLLNRRRAARRRR	IGSF9	756	Q9P2J2
VSGRRSRPRERDRER	YTHDC1	671	Q96MU7
RRRRARDRPTICGEC	ZNF853	476	P0CG23
EGRRRSRRVRLRGSC	TOPORS	26	Q9NS56
LRRLRTRGCGTRQDA	PLEKHG7	51	Q6ZR37
ATGRRGLIRLRRDGD	ZAR1L	136	A6NP61
GLRAGSRRDRDRDFR	UBR5	2351	O95071
HGSRARGRALERRRR	KDM5C	1446	P41229
GLTACRARRRRLRTA	LRRC26	286	Q2I0M4
RLCGSRRAGRRALRS	NECAB3	186	Q96P71