Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionpeptidase activity

ERVK-18 TRHDE USP44 USP34 OVCH2 ADAMTS5 KLK1

2.85e-04654407GO:0008233
GeneOntologyMolecularFunctionendopeptidase activity

ERVK-18 USP34 OVCH2 ADAMTS5 KLK1

1.60e-03430405GO:0004175
DomainG-protein_beta_WD-40_rep

FBXW10B FBXW10 TBL3

8.56e-0485413IPR020472
DomainSpectrin/alpha-actinin

SPTBN5 MCF2L2

2.24e-0332412IPR018159
DomainSPEC

SPTBN5 MCF2L2

2.24e-0332412SM00150
DomainWD40_repeat_CS

FBXW10B FBXW10 TBL3

5.55e-03164413IPR019775
DomainGal_Oxase/kelch_b-propeller

KLHDC2 TBL3

7.43e-0359412IPR011043
DomainTSP_1

ADAMTS5 UNC5D

8.44e-0363412PF00090
DomainTSP1

ADAMTS5 UNC5D

8.96e-0365412SM00209
DomainTSP1_rpt

ADAMTS5 UNC5D

8.96e-0365412IPR000884
DomainTSP1

ADAMTS5 UNC5D

8.96e-0365412PS50092
DomainUSP_CS

USP44 USP34

9.23e-0366412IPR018200
DomainUSP_1

USP44 USP34

1.03e-0270412PS00972
DomainUCH

USP44 USP34

1.06e-0271412PF00443
DomainUSP_2

USP44 USP34

1.06e-0271412PS00973
DomainUSP_3

USP44 USP34

1.09e-0272412PS50235
DomainUSP_dom

USP44 USP34

1.09e-0272412IPR028889
DomainPeptidase_C19_UCH

USP44 USP34

1.09e-0272412IPR001394
Pubmed

Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male transgenic mice.

FBXW10B FBXW10

1.49e-06243237450367
Pubmed

FBXW10 promotes hepatocarcinogenesis in male patients and mice.

FBXW10B FBXW10

1.49e-06243231400758
Pubmed

FBXW10-S6K1 promotes ANXA2 polyubiquitination and KRAS activation to drive hepatocellular carcinoma development in males.

FBXW10B FBXW10

1.49e-05543237277019
Pubmed

Epigenetic displacement of HP1 from heterochromatin by HIV-1 Vpr causes premature sister chromatid separation.

SGO1 EP300

1.35e-041443221875947
Pubmed

Human and mouse proteases: a comparative genomic approach.

USP44 USP34 OVCH2

1.40e-048143312838346
Pubmed

Dioxin receptor is a ligand-dependent E3 ubiquitin ligase.

TBL3 EP300

2.52e-041943217392787
Pubmed

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.

ZNF638 TUBGCP2 MAST2 TBL3 TMLHE

2.57e-0446243531138677
Pubmed

Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling.

USP44 USP34

3.40e-042243226811477
Pubmed

Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.

USP44 USP34

3.72e-042343214715245
Pubmed

The CARM1-p300-c-Myc-Max (CPCM) transcriptional complex regulates the expression of CUL4A/4B and affects the stability of CRL4 E3 ligases in colorectal cancer.

USP34 EP300

7.69e-043343232140074
InteractionFBXW10B interactions

FBXW10B FBXW10

1.15e-053402int:FBXW10B
Cytoband17p12

FBXW10B FBXW10

9.80e-044943217p12
Cytoband10q26.3

SCART1 TUBGCP2

1.06e-035143210q26.3
Cytoband17q25.1

UNC13D GPR142

2.65e-038143217q25.1
GeneFamilyWD repeat domain containing|F-box and WD repeat domain containing

FBXW10B FBXW10

1.26e-0411282559
GeneFamilyUbiquitin specific peptidases

USP44 USP34

3.38e-0356282366
GeneFamilyG protein-coupled receptors, Class A orphans

GPR142 GPR68

6.46e-0378282262
GeneFamilyWD repeat domain containing

FBXW10B FBXW10 TBL3

7.54e-03262283362
ToppCell368C-Epithelial_cells-Epithelial-B_(AT2)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

DOCK5 MARCHF1 YAE1 MCF2L2

3.16e-06107424410b37beffaf637a2a64c9d0ce7baf81f4bc667c
ToppCell368C-Epithelial_cells-Epithelial-B_(AT2)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

DOCK5 MARCHF1 YAE1 MCF2L2

3.16e-061074245bae4b3aede9bcbf7e88414e3453973cc8b0c3e7
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRHDE SGO1 MARCHF1 UNC5D

6.43e-06128424e100629f6038e32176ffcc81bd06bd175df46cef
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRHDE MARCHF1 ABCA13 UNC5D

1.71e-05164424382e42701779d12a7948690b3be72d06dd75c8b4
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.4.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ANKRD18A SGO1 ABCA13 DOP1B

1.97e-05170424cf22a843ae2d9cd6693507fed2b7c6a45abea10e
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRHDE MARCHF1 ABCA13 UNC5D

2.26e-05176424327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRHDE MARCHF1 ABCA13 UNC5D

2.31e-05177424da8802a6351d3e510822f82e2fde8a4314a2216e
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TRHDE MARCHF1 ABCA13 UNC5D

2.36e-05178424c20f050344a2e120e685e2a7fe36c6dfc1dc37b6
ToppCell5'-GW_trimst-1.5-LargeIntestine-Hematopoietic-T_cells-ILCP|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

USP44 SCART1 EYS GPR68

2.46e-05180424ca7c316027e31559103b2cab1a2c0de993e42e95
ToppCell5'-GW_trimst-1.5-LargeIntestine-Hematopoietic-T_cells|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

USP44 SCART1 EYS GPR68

2.46e-05180424eb26ba86fba26899e54c448afc25382ddc853013
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRHDE MARCHF1 ABCA13 UNC5D

2.52e-051814249d782ba5cf5a172cb4f447763fc50e5b13ef7dd9
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRHDE MARCHF1 ABCA13 UNC5D

2.52e-05181424071f9bb5d39070cdc473d9b0e094d196bc702b56
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRHDE MARCHF1 ABCA13 UNC5D

2.52e-051814246956ecd6264f7469a25e555673bce4eb97d28f7a
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRHDE MARCHF1 ABCA13 UNC5D

2.57e-05182424eb138aa1dca9373f1586600f258df06dcf56d81f
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRHDE MARCHF1 ABCA13 UNC5D

2.57e-051824245e1b316599436740f1b30875f0ebd33c3edfb2b6
ToppCell5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-T_cells-LTi-like_NCR+_ILC3|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

UNC13D SCART1 EYS GPR68

2.63e-05183424c7fedb5b0c1f17b3391ce1c4a6bfca7615c359c5
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRHDE MARCHF1 ABCA13 UNC5D

2.63e-05183424738e94b50c4c08c727d4eed0708dda08aa6891b4
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRHDE MARCHF1 ABCA13 UNC5D

2.63e-0518342492fbd83a9d13ee91065cbd479fb298f1fd564568
ToppCellControl-Myeloid-Macrophage_Alveolar|World / Disease state, Lineage and Cell class

TRHDE MR1 CD163L1 MCF2L2

2.74e-0518542485cb81759589a26d83676cffbf2bc37399683c10
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRHDE MARCHF1 ABCA13 UNC5D

2.80e-051864245c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRHDE MARCHF1 ABCA13 UNC5D

2.92e-0518842463a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRHDE MARCHF1 ABCA13 UNC5D

2.98e-05189424904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRHDE MARCHF1 ABCA13 UNC5D

3.10e-05191424d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCellnucseq|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

USP34 BTBD9 CD163L1 MCF2L2

3.23e-05193424779276e775cb2492e8dd36436295a536084a6415
Diseasedihydroxy docosatrienoic acid measurement

TRHDE EYS

8.23e-0432392EFO_0005275
DiseaseObesity

NPY1R BBS12 EP300

2.51e-03205393C0028754

Protein segments in the cluster

PeptideGeneStartEntry
NKHCHQQASTLISDW

TRHDE

826

Q9UKU6
AHCASSRQIISHWKN

EP300

391

Q09472
TLEHHFQLQCDWNTS

ERVK-18

431

O42043
SHCHINLNETWTSKK

ANKRD18A

646

Q8IVF6
TTLKNFCKWQHQHNQ

ADAMTS5

336

Q9UNA0
HTLNKCASVSQHWAA

FBXW10

296

Q5XX13
NEWCHLQEDTNSHIQ

ANKRD62

686

A6NC57
FADSSHSWNVNHLLQ

ABCA13

1716

Q86UQ4
WLCKEANQHCTVSDH

ABCA13

4956

Q86UQ4
VCHHKWNNAAADVVC

CD163L1

286

Q9NR16
QSLKKENHACSGWLH

BBS12

556

Q6ZW61
HTLNKCASVSQHWAA

FBXW10B

296

O95170
CCNKWHHVVVIQNQT

EYS

3061

Q5T1H1
HRQWVLTAAHCISDN

KLK1

56

P06870
WNQLNKETREHHVTC

DOP1B

881

Q9Y3R5
SHFWSEHHLKLNQCL

MCF2L2

306

Q86YR7
NNWHIFLQNCLSHLK

FRYL

331

O94915
SNKTAKQHSLHSAQW

TUBGCP2

661

Q9BSJ2
WTLDQHHIANLCDSL

FOXJ2

456

Q9P0K8
VHQSCLHQWIKSSDT

MARCHF1

106

Q8TCQ1
FDWNHQIIATCNHNL

NPY1R

286

P25929
NCVQQHAWDRSLSVH

DOCK5

1531

Q9H7D0
SAECQNHIFIWQTHN

DYM

91

Q7RTS9
HAQKSQHSCLSHSRW

GPR142

41

Q7Z601
CWKAQHLHTQALTAL

MAST2

1616

Q6P0Q8
NSWNCLPKHLLHSVN

KLHDC2

381

Q9Y2U9
LLNWCKHNSKENHAE

BTBD9

206

Q96Q07
NVAHTIKQAWEANQH

MR1

156

Q95460
VLQHDNWSHGDLSCQ

GPR68

81

Q15743
ANCDWIFQASKHHLI

OVCH2

456

Q7RTZ1
HIPENVQHNACQWSK

SGO1

236

Q5FBB7
TATCANHQAWLHLDN

SPTBN5

1221

Q9NRC6
SWKSSCINHEKIHNA

ZIM3

261

Q96PE6
CTQILAFSHKVQLWH

nan

151

Q6ZTK2
WNTNSRHCHEAQAVL

TBL3

721

Q12788
HWDIADATVLCHQLN

SCART1

356

Q4G0T1
KCNGEWVHQNEHVSE

UNC5D

86

Q6UXZ4
LLSWCHLHNNNSTLI

YAE1

86

Q9NRH1
LEKQNNESWENHTTC

ZNF280C

341

Q8ND82
TQHIDCIWAAAQLKH

USP34

406

Q70CQ2
SKSLTCAWQQHEDHF

TMLHE

46

Q9NVH6
DLHQCQRTWDKIFHN

UNC13D

501

Q70J99
AQDHSSLNPQKWHCV

USP44

16

Q9H0E7
CNVECSHLKDWIQHQ

ZNF638

431

Q14966
WKKNLATHQCLHRSE

ZNF467

366

Q7Z7K2