Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	inhibitory MHC class I receptor activity	LILRA1 LILRA3 LILRB1	1.50e-06	12	39	3	GO:0032396
GeneOntologyMolecularFunction	MHC class I receptor activity	LILRA1 LILRA3 LILRB1	5.51e-06	18	39	3	GO:0032393
GeneOntologyMolecularFunction	HLA-A specific inhibitory MHC class I receptor activity	LILRA1 LILRB1	3.70e-05	5	39	2	GO:0030107
GeneOntologyMolecularFunction	amyloid-beta binding	LILRA1 ATP1A3 LILRB1 SORL1	4.60e-05	102	39	4	GO:0001540
GeneOntologyMolecularFunction	HLA-B specific inhibitory MHC class I receptor activity	LILRA1 LILRB1	5.55e-05	6	39	2	GO:0030109
GeneOntologyMolecularFunction	MHC class Ib protein complex binding	LILRA1 LILRB1	7.76e-05	7	39	2	GO:0023025
GeneOntologyMolecularFunction	IgM binding	LILRA1 LILRB1	2.02e-04	11	39	2	GO:0001791
GeneOntologyMolecularFunction	MHC class Ib protein binding	LILRA1 LILRB1	4.38e-04	16	39	2	GO:0023029
GeneOntologyMolecularFunction	MHC class Ib receptor activity	LILRA1 LILRB1	6.22e-04	19	39	2	GO:0032394
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	EPS8L2 DOCK6 SBF2 PLCE1	1.04e-03	231	39	4	GO:0005085
GeneOntologyMolecularFunction	phosphatase binding	DLG3 LILRA1 LILRB1 SBF2	1.71e-03	264	39	4	GO:0019902
GeneOntologyMolecularFunction	MHC class I protein binding	LILRA1 LILRB1	1.78e-03	32	39	2	GO:0042288
GeneOntologyMolecularFunction	protein phosphatase 1 binding	LILRA1 LILRB1	2.12e-03	35	39	2	GO:0008157
GeneOntologyMolecularFunction	P-type transmembrane transporter activity	ATP1A3 ATP2A2	2.25e-03	36	39	2	GO:0140358
GeneOntologyMolecularFunction	P-type ion transporter activity	ATP1A3 ATP2A2	2.25e-03	36	39	2	GO:0015662
GeneOntologyMolecularFunction	immunoglobulin binding	LILRA1 LILRB1	2.25e-03	36	39	2	GO:0019865
GeneOntologyMolecularFunction	amide binding	LILRA1 ATP1A3 LILRB1 SORL1	2.68e-03	299	39	4	GO:0033218
GeneOntologyMolecularFunction	MHC protein complex binding	LILRA1 LILRB1	2.90e-03	41	39	2	GO:0023023
GeneOntologyMolecularFunction	peptide binding	LILRA1 ATP1A3 LILRB1 SORL1	3.35e-03	318	39	4	GO:0042277
GeneOntologyMolecularFunction	immune receptor activity	LILRA1 LILRA3 LILRB1	4.07e-03	165	39	3	GO:0140375
GeneOntologyMolecularFunction	ionotropic glutamate receptor binding	DLG3 NETO1	4.63e-03	52	39	2	GO:0035255
GeneOntologyMolecularFunction	SH2 domain binding	LILRA1 LILRB1	4.63e-03	52	39	2	GO:0042169
GeneOntologyMolecularFunction	MHC protein binding	LILRA1 LILRB1	5.73e-03	58	39	2	GO:0042287
GeneOntologyMolecularFunction	ATPase-coupled monoatomic cation transmembrane transporter activity	ATP1A3 ATP2A2	6.53e-03	62	39	2	GO:0019829
GeneOntologyMolecularFunction	ATP-dependent activity	ATP1A3 ZCWPW2 ATP2A2 HSPA4 DNAH14	6.56e-03	614	39	5	GO:0140657
GeneOntologyMolecularFunction	metallopeptidase activity	ATP23 EIF3H PITRM1	6.94e-03	200	39	3	GO:0008237
GeneOntologyBiologicalProcess	interleukin-10-mediated signaling pathway	LILRA1 LILRA3 LILRB1	1.02e-06	11	39	3	GO:0140105
GeneOntologyBiologicalProcess	anterograde trans-synaptic signaling	DLG3 PRKN LILRA1 ATP1A3 SEPTIN5 ATP2A2 NETO1 LILRB1 RPH3A	4.67e-05	931	39	9	GO:0098916
GeneOntologyBiologicalProcess	chemical synaptic transmission	DLG3 PRKN LILRA1 ATP1A3 SEPTIN5 ATP2A2 NETO1 LILRB1 RPH3A	4.67e-05	931	39	9	GO:0007268
GeneOntologyBiologicalProcess	trans-synaptic signaling	DLG3 PRKN LILRA1 ATP1A3 SEPTIN5 ATP2A2 NETO1 LILRB1 RPH3A	4.99e-05	939	39	9	GO:0099537
GeneOntologyBiologicalProcess	synaptic signaling	DLG3 PRKN LILRA1 ATP1A3 SEPTIN5 ATP2A2 NETO1 LILRB1 RPH3A	6.73e-05	976	39	9	GO:0099536
GeneOntologyBiologicalProcess	regulation of exocytosis	PRKN SEPTIN5 SEPTIN4 ATP2A2 RPH3A	7.42e-05	233	39	5	GO:0017157
GeneOntologyBiologicalProcess	regulation of cardiac muscle cell membrane potential	ATP1A3 ATP2A2	1.90e-04	11	39	2	GO:0086036
GeneOntologyBiologicalProcess	modulation of chemical synaptic transmission	PRKN LILRA1 ATP1A3 SEPTIN5 ATP2A2 NETO1 LILRB1	2.16e-04	663	39	7	GO:0050804
GeneOntologyBiologicalProcess	regulation of trans-synaptic signaling	PRKN LILRA1 ATP1A3 SEPTIN5 ATP2A2 NETO1 LILRB1	2.18e-04	664	39	7	GO:0099177
GeneOntologyBiologicalProcess	regulation of vesicle-mediated transport	PRKN SEPTIN5 SEPTIN4 ATP2A2 LILRB1 RPH3A SORL1	2.24e-04	667	39	7	GO:0060627
GeneOntologyBiologicalProcess	spontaneous neurotransmitter secretion	PRKN RPH3A	2.27e-04	12	39	2	GO:0061669
GeneOntologyBiologicalProcess	positive regulation of long-term synaptic depression	LILRA1 LILRB1	3.12e-04	14	39	2	GO:1900454
GeneOntologyBiologicalProcess	negative regulation of synaptic transmission	PRKN LILRA1 LILRB1	4.64e-04	80	39	3	GO:0050805
GeneOntologyBiologicalProcess	signal release from synapse	PRKN SEPTIN5 ATP2A2 RPH3A	4.92e-04	195	39	4	GO:0099643
GeneOntologyBiologicalProcess	neurotransmitter secretion	PRKN SEPTIN5 ATP2A2 RPH3A	4.92e-04	195	39	4	GO:0007269
GeneOntologyBiologicalProcess	spontaneous synaptic transmission	PRKN RPH3A	5.23e-04	18	39	2	GO:0098814
GeneOntologyCellularComponent	Fc-epsilon receptor I complex	LILRA1 LILRB1	1.21e-04	9	39	2	GO:0032998
GeneOntologyCellularComponent	Fc receptor complex	LILRA1 LILRB1	2.21e-04	12	39	2	GO:0032997
GeneOntologyCellularComponent	septin complex	SEPTIN5 SEPTIN4	3.04e-04	14	39	2	GO:0031105
GeneOntologyCellularComponent	septin ring	SEPTIN5 SEPTIN4	3.04e-04	14	39	2	GO:0005940
GeneOntologyCellularComponent	septin cytoskeleton	SEPTIN5 SEPTIN4	4.00e-04	16	39	2	GO:0032156
GeneOntologyCellularComponent	cell division site	SEPTIN5 TUBGCP5 SEPTIN4	4.47e-04	80	39	3	GO:0032153
GeneOntologyCellularComponent	axon terminus	PRKN ATP1A3 SEPTIN5 SEPTIN4	6.18e-04	210	39	4	GO:0043679
GeneOntologyCellularComponent	dopaminergic synapse	PRKN SEPTIN4	7.65e-04	22	39	2	GO:0098691
GeneOntologyCellularComponent	neuron projection terminus	PRKN ATP1A3 SEPTIN5 SEPTIN4	9.11e-04	233	39	4	GO:0044306
GeneOntologyCellularComponent	axon	DLG3 PRKN ATP1A3 SEPTIN5 SEPTIN4 NETO1 SBF2	1.16e-03	891	39	7	GO:0030424
GeneOntologyCellularComponent	distal axon	DLG3 PRKN ATP1A3 SEPTIN5 SEPTIN4	1.23e-03	435	39	5	GO:0150034
GeneOntologyCellularComponent	calyx of Held	ATP1A3 SEPTIN5	2.05e-03	36	39	2	GO:0044305
GeneOntologyCellularComponent	synaptic vesicle	PRKN SEPTIN5 SEPTIN4 RPH3A	2.30e-03	300	39	4	GO:0008021
GeneOntologyCellularComponent	transport vesicle	PRKN SEPTIN5 SEPTIN4 RPH3A SORL1	2.65e-03	519	39	5	GO:0030133
GeneOntologyCellularComponent	exocytic vesicle	PRKN SEPTIN5 SEPTIN4 RPH3A	2.91e-03	320	39	4	GO:0070382
GeneOntologyCellularComponent	cation-transporting ATPase complex	ATP1A3 ATP2A2	3.77e-03	49	39	2	GO:0090533
MousePheno	tau protein deposits	PRKN HSPA4 SORL1	1.31e-06	11	29	3	MP:0004250
MousePheno	nervous system inclusion bodies	PRKN PITRM1 HSPA4 SORL1	1.58e-06	42	29	4	MP:0014062
MousePheno	abnormal learning/memory/conditioning	TPO DLG3 PRKN EPS8L2 ATP1A3 SEPTIN5 NETO1 HSPA4 RTRAF KCTD16 SORL1	1.96e-05	1239	29	11	MP:0002063
MousePheno	abnormal cognition	TPO DLG3 PRKN EPS8L2 ATP1A3 SEPTIN5 NETO1 HSPA4 RTRAF KCTD16 SORL1	2.06e-05	1246	29	11	MP:0014114
MousePheno	brain lesion	PRKN HSPA4 SORL1	1.47e-04	50	29	3	MP:0021002
MousePheno	decreased length of allograft survival	LILRA1 LILRB1	1.48e-04	9	29	2	MP:0004752
MousePheno	abnormal spatial learning	DLG3 PRKN ATP1A3 SEPTIN5 SORL1	2.33e-04	276	29	5	MP:0001463
MousePheno	abnormal visual cortex morphology	LILRA1 LILRB1	4.90e-04	16	29	2	MP:0000805
MousePheno	limb grasping	TPO ATP1A3 PITRM1 HSPA4 SBF2	4.94e-04	325	29	5	MP:0001513
MousePheno	amyloid beta deposits	PITRM1 SORL1	5.54e-04	17	29	2	MP:0003329
Domain	A1B_glyco/leuk_Ig-like_rcpt	LILRA1 LILRA3	6.34e-05	6	39	2	IPR016332
Domain	Septin	SEPTIN5 SEPTIN4	3.27e-04	13	39	2	PF00735
Domain	G_SEPTIN_dom	SEPTIN5 SEPTIN4	3.27e-04	13	39	2	IPR030379
Domain	G_SEPTIN	SEPTIN5 SEPTIN4	3.27e-04	13	39	2	PS51719
Domain	Septin	SEPTIN5 SEPTIN4	3.81e-04	14	39	2	IPR016491
Domain	Ig_2	LILRA1 LILRA3 LILRB1	4.73e-04	73	39	3	PF13895
Domain	-	ATP1A3 ATP2A2	5.01e-04	16	39	2	1.20.1110.10
Domain	ATPase_P-typ_TM_dom	ATP1A3 ATP2A2	5.01e-04	16	39	2	IPR023298
Domain	ATPase_P-typ_cation-transptr_C	ATP1A3 ATP2A2	5.66e-04	17	39	2	IPR006068
Domain	Cation_ATPase_C	ATP1A3 ATP2A2	5.66e-04	17	39	2	PF00689
Domain	Cation_ATPase_N	ATP1A3 ATP2A2	6.36e-04	18	39	2	PF00690
Domain	Cation_ATPase_N	ATP1A3 ATP2A2	6.36e-04	18	39	2	SM00831
Domain	ATPase_P-typ_cation-transptr_N	ATP1A3 ATP2A2	7.10e-04	19	39	2	IPR004014
Domain	-	ATP1A3 ATP2A2	2.03e-03	32	39	2	2.70.150.10
Domain	-	ATP1A3 ATP2A2	2.03e-03	32	39	2	3.40.1110.10
Domain	ATPase_P-typ_cyto_domN	ATP1A3 ATP2A2	2.42e-03	35	39	2	IPR023299
Domain	ATPase_P-typ_P_site	ATP1A3 ATP2A2	2.56e-03	36	39	2	IPR018303
Domain	P_typ_ATPase	ATP1A3 ATP2A2	2.56e-03	36	39	2	IPR001757
Domain	ATPASE_E1_E2	ATP1A3 ATP2A2	2.56e-03	36	39	2	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP1A3 ATP2A2	2.70e-03	37	39	2	IPR008250
Domain	E1-E2_ATPase	ATP1A3 ATP2A2	2.70e-03	37	39	2	PF00122
Domain	LDLR_class-A_CS	NETO1 SORL1	3.15e-03	40	39	2	IPR023415
Domain	Ldl_recept_a	NETO1 SORL1	3.97e-03	45	39	2	PF00057
Domain	-	NETO1 SORL1	4.15e-03	46	39	2	4.10.400.10
Domain	LDLRA_1	NETO1 SORL1	4.51e-03	48	39	2	PS01209
Domain	LDrepeatLR_classA_rpt	NETO1 SORL1	4.70e-03	49	39	2	IPR002172
Domain	LDLa	NETO1 SORL1	4.70e-03	49	39	2	SM00192
Domain	LDLRA_2	NETO1 SORL1	4.70e-03	49	39	2	PS50068
Domain	ig	LILRA1 LILRA3 LILRB1	7.24e-03	190	39	3	PF00047
Domain	Immunoglobulin	LILRA1 LILRA3 LILRB1	7.24e-03	190	39	3	IPR013151
Domain	HAD-like_dom	ATP1A3 ATP2A2	1.18e-02	79	39	2	IPR023214
Pathway	BIOCARTA_PARKIN_PATHWAY	PRKN SEPTIN5	1.14e-04	8	29	2	MM1486
Pubmed	LILRA3 binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1/LILRB2: structural evidence.	LILRA1 LILRA3 LILRB1	5.21e-09	4	39	3	21559424
Pubmed	SEPT5_v2 is a parkin-binding protein.	PRKN SEPTIN5 SEPTIN4	5.21e-09	4	39	3	14559152
Pubmed	HLA class I allelic sequence and conformation regulate leukocyte Ig-like receptor binding.	LILRA1 LILRA3 LILRB1	5.21e-09	4	39	3	21270408
Pubmed	A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules.	LILRA1 LILRA3 LILRB1	7.27e-08	8	39	3	9548455
Pubmed	Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity.	PRKN SEPTIN5 HSPA4	2.14e-07	11	39	3	16714300
Pubmed	Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression.	PRKN SEPTIN5 HSPA4	2.14e-07	11	39	3	29180628
Pubmed	140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry.	SEPTIN5 SEPTIN4 RPH3A RTRAF SBF2	1.08e-06	163	39	5	16512683
Pubmed	Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity.	TIA1 SEPTIN5 SEPTIN4 ATP2A2 RPH3A	1.18e-06	166	39	5	27160897
Pubmed	The effect of LILRB1 but not LILRA3 gene polymorphism in immunopathology of ankylosing spondylitis-A parallel to KIR genes.	LILRA3 LILRB1	1.23e-06	2	39	2	30892832
Pubmed	Soluble LILRA3, a potential natural antiinflammatory protein, is increased in patients with rheumatoid arthritis and is tightly regulated by interleukin 10, tumor necrosis factor-alpha, and interferon-gamma.	LILRA1 LILRA3	1.23e-06	2	39	2	20595277
Pubmed	Leukocyte receptor complex-encoded immunomodulatory receptors show differing specificity for alternative HLA-B27 structures.	LILRA1 LILRA3	1.23e-06	2	39	2	11698424
Pubmed	Neurotoxicity and behavioral deficits associated with Septin 5 accumulation in dopaminergic neurons.	PRKN SEPTIN5	1.23e-06	2	39	2	16092945
Pubmed	Chronic overload of SEPT4, a parkin substrate that aggregates in Parkinson's disease, causes behavioral alterations but not neurodegeneration in mice.	PRKN SEPTIN4	1.23e-06	2	39	2	23938054
Pubmed	Parkin mediates the degradation-independent ubiquitination of Hsp70.	PRKN HSPA4	3.67e-06	3	39	2	18248624
Pubmed	Human septin-septin interactions as a prerequisite for targeting septin complexes in the cytosol.	SEPTIN5 SEPTIN4	3.67e-06	3	39	2	15214843
Pubmed	Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function.	PRKN HSPA4	3.67e-06	3	39	2	12676955
Pubmed	Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4.	LILRA1 LILRB1	3.67e-06	3	39	2	10941837
Pubmed	The novel human platelet septin SEPT8 is an interaction partner of SEPT4.	SEPTIN5 SEPTIN4	3.67e-06	3	39	2	15116257
Pubmed	Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitination.	PRKN HSPA4	7.34e-06	4	39	2	17512523
Pubmed	Plasticity in the organization and sequences of human KIR/ILT gene families.	LILRA1 LILRA3	7.34e-06	4	39	2	10781084
Pubmed	Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1.	PRKN SEPTIN5	7.34e-06	4	39	2	11078524
Pubmed	Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death.	PRKN HSPA4	7.34e-06	4	39	2	16135753
Pubmed	Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress.	PRKN HSPA4	7.34e-06	4	39	2	15525661
Pubmed	PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility.	PRKN RHOT2	7.34e-06	4	39	2	22078885
Pubmed	Modulation of ARTS and XIAP by Parkin Is Associated with Carnosic Acid Protects SH-SY5Y Cells against 6-Hydroxydopamine-Induced Apoptosis.	PRKN SEPTIN4	7.34e-06	4	39	2	28224479
Pubmed	CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins.	PRKN HSPA4	7.34e-06	4	39	2	18784277
Pubmed	A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells.	LILRA3 LILRB1	7.34e-06	4	39	2	9382880
Pubmed	PirB regulates a structural substrate for cortical plasticity.	LILRA1 LILRB1	1.22e-05	5	39	2	24302763
Pubmed	Spatio-temporal expression of paired immunoglobulin-like receptor-B in the adult mouse brain after focal cerebral ischaemia.	LILRA1 LILRB1	1.22e-05	5	39	2	23927735
Pubmed	Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity.	SEPTIN5 SEPTIN4	1.22e-05	5	39	2	17296554
Pubmed	Regulation of cytotoxic T lymphocyte triggering by PIR-B on dendritic cells.	LILRA1 LILRB1	1.22e-05	5	39	2	18787130
Pubmed	Parkin regulates Eg5 expression by Hsp70 ubiquitination-dependent inactivation of c-Jun NH2-terminal kinase.	PRKN SEPTIN5	1.22e-05	5	39	2	18845538
Pubmed	Enhancing motor learning by increasing the stability of newly formed dendritic spines in the motor cortex.	LILRA1 LILRB1	1.22e-05	5	39	2	34437845
Pubmed	Paired immunoglobulin-like receptor B is an entry receptor for mammalian orthoreovirus.	LILRA1 LILRB1	1.22e-05	5	39	2	37147336
Pubmed	Tumor-derived ILT4 induces T cell senescence and suppresses tumor immunity.	LILRA1 LILRB1	1.22e-05	5	39	2	33653799
Pubmed	PIR-B Regulates CD4+ IL17a+ T-Cell Survival and Restricts T-Cell-Dependent Intestinal Inflammatory Responses.	LILRA1 LILRB1	1.22e-05	5	39	2	34242819
Pubmed	Paired immunoglobulin-like receptor B knockout does not enhance axonal regeneration or locomotor recovery after spinal cord injury.	LILRA1 LILRB1	1.22e-05	5	39	2	21087927
Pubmed	Paired immunoglobulin-like receptor B (PIR-B) negatively regulates macrophage activation in experimental colitis.	LILRA1 LILRB1	1.22e-05	5	39	2	20398663
Pubmed	The LILR family: modulators of innate and adaptive immune pathways in health and disease.	LILRA1 LILRB1	1.22e-05	5	39	2	15304001
Pubmed	Structure and flexibility of the extracellular region of the PirB receptor.	LILRA1 LILRB1	1.22e-05	5	39	2	30674550
Pubmed	Inhibitory receptor paired Ig-like receptor B is exploited by Staphylococcus aureus for virulence.	LILRA1 LILRB1	1.22e-05	5	39	2	23152562
Pubmed	Regulation of plasmacytoid dendritic cell responses by PIR-B.	LILRA1 LILRB1	1.22e-05	5	39	2	22948046
Pubmed	Molecular cloning of a novel murine cell-surface glycoprotein homologous to killer cell inhibitory receptors.	LILRA1 LILRB1	1.22e-05	5	39	2	9054430
Pubmed	CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation.	PRKN HSPA4	1.22e-05	5	39	2	14962978
Pubmed	Role of PIR-B in autoimmune glomerulonephritis.	LILRA1 LILRB1	1.22e-05	5	39	2	20976309
Pubmed	Paternal monoallelic expression of the paired immunoglobulin-like receptors PIR-A and PIR-B.	LILRA1 LILRB1	1.22e-05	5	39	2	10359805
Pubmed	Paired Ig-like Receptor B Inhibits IL-13-Driven Eosinophil Accumulation and Activation in the Esophagus.	LILRA1 LILRB1	1.22e-05	5	39	2	27324131
Pubmed	Genetic deletion of paired immunoglobulin-like receptor B does not promote axonal plasticity or functional recovery after traumatic brain injury.	LILRA1 LILRB1	1.22e-05	5	39	2	20881122
Pubmed	Characterization of paired Ig-like receptors in rats.	LILRA1 LILRB1	1.22e-05	5	39	2	10586026
Pubmed	Paired immunoglobulin-like receptor B regulates platelet activation.	LILRA1 LILRB1	1.22e-05	5	39	2	25075127
Pubmed	Genomic structure of PIR-B, the inhibitory member of the paired immunoglobulin-like receptor genes in mice.	LILRA1 LILRB1	1.22e-05	5	39	2	9550322
Pubmed	Expression of PirB protein in intact and injured optic nerve and retina of mice.	LILRA1 LILRB1	1.22e-05	5	39	2	22102155
Pubmed	Paired immunoglobulin-like receptors and their MHC class I recognition.	LILRA1 LILRB1	1.22e-05	5	39	2	16011512
Pubmed	PirB Overexpression Exacerbates Neuronal Apoptosis by Inhibiting TrkB and mTOR Phosphorylation After Oxygen and Glucose Deprivation Injury.	LILRA1 LILRB1	1.22e-05	5	39	2	27443384
Pubmed	Paired immunoglobulin-like receptor-B inhibits pulmonary fibrosis by suppressing profibrogenic properties of alveolar macrophages.	LILRA1 LILRB1	1.22e-05	5	39	2	23258232
Pubmed	The inhibitory receptor PIR-B negatively regulates neutrophil and macrophage integrin signaling.	LILRA1 LILRB1	1.22e-05	5	39	2	15494528
Pubmed	Ectopically expressed PIR-B on T cells constitutively binds to MHC class I and attenuates T helper type 1 responses.	LILRA1 LILRB1	1.22e-05	5	39	2	19684158
Pubmed	Mast cell regulation via paired immunoglobulin-like receptor PIR-B.	LILRA1 LILRB1	1.22e-05	5	39	2	12403357
Pubmed	PirB negatively regulates the inflammatory activation of astrocytes in a mouse model of sleep deprivation.	LILRA1 LILRB1	1.22e-05	5	39	2	37146940
Pubmed	PirB functions as an intrinsic suppressor in hippocampal neural stem cells.	LILRA1 LILRB1	1.22e-05	5	39	2	34120891
Pubmed	Exacerbated graft-versus-host disease in Pirb-/- mice.	LILRA1 LILRB1	1.83e-05	6	39	2	15146181
Pubmed	PIR-B-deficient mice are susceptible to Salmonella infection.	LILRA1 LILRB1	1.83e-05	6	39	2	18768880
Pubmed	CAMKs support development of acute myeloid leukemia.	LILRA1 LILRB1	1.83e-05	6	39	2	29482582
Pubmed	Autoimmune arthritis induces paired immunoglobulin-like receptor B expression on CD4+ T cells from SKG mice.	LILRA1 LILRB1	1.83e-05	6	39	2	28664612
Pubmed	LILRB2/PirB mediates macrophage recruitment in fibrogenesis of nonalcoholic steatohepatitis.	LILRA1 LILRB1	1.83e-05	6	39	2	37481670
Pubmed	Dual functions of angiopoietin-like protein 2 signaling in tumor progression and anti-tumor immunity.	LILRA1 LILRB1	1.83e-05	6	39	2	31727773
Pubmed	Blocking PirB up-regulates spines and functional synapses to unlock visual cortical plasticity and facilitate recovery from amblyopia.	LILRA1 LILRB1	1.83e-05	6	39	2	25320232
Pubmed	HLA-G inhibits the functions of murine dendritic cells via the PIR-B immune inhibitory receptor.	LILRA1 LILRB1	1.83e-05	6	39	2	12207326
Pubmed	Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons.	PRKN SEPTIN5	1.83e-05	6	39	2	12930822
Pubmed	Cell-Autonomous Regulation of Dendritic Spine Density by PirB.	LILRA1 LILRB1	1.83e-05	6	39	2	27752542
Pubmed	Systematic and standardized comparison of reported amyloid-β receptors for sufficiency, affinity, and Alzheimer's disease relevance.	LILRA1 LILRB1	1.83e-05	6	39	2	30787106
Pubmed	The major SHP-1-binding, tyrosine-phosphorylated protein in macrophages is a member of the KIR/LIR family and an SHP-1 substrate.	LILRA1 LILRB1	1.83e-05	6	39	2	9824165
Pubmed	CaSSiDI: novel single-cell "Cluster Similarity Scoring and Distinction Index" reveals critical functions for PirB and context-dependent Cebpb repression.	LILRA1 LILRB1	1.83e-05	6	39	2	38383888
Pubmed	Inhibition of ANGPTL8 protects against diabetes-associated cognitive dysfunction by reducing synaptic loss via the PirB signaling pathway.	LILRA1 LILRB1	1.83e-05	6	39	2	39095838
Pubmed	PirB is a functional receptor for myelin inhibitors of axonal regeneration.	LILRA1 LILRB1	1.83e-05	6	39	2	18988857
Pubmed	Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways.	LILRA3 LILRB1	1.83e-05	6	39	2	9079806
Pubmed	Structural insights into Parkin substrate lysine targeting from minimal Miro substrates.	PRKN RHOT2	1.83e-05	6	39	2	27605430
Pubmed	Differential but competitive binding of Nogo protein and class i major histocompatibility complex (MHCI) to the PIR-B ectodomain provides an inhibition of cells.	LILRA1 LILRB1	1.83e-05	6	39	2	21636572
Pubmed	Mice Deficient in Angiopoietin-like Protein 2 (Angptl2) Gene Show Increased Susceptibility to Bacterial Infection Due to Attenuated Macrophage Activity.	LILRA1 LILRB1	1.83e-05	6	39	2	27402837
Pubmed	Characterization of regulatory dendritic cells that mitigate acute graft-versus-host disease in older mice following allogeneic bone marrow transplantation.	LILRA1 LILRB1	1.83e-05	6	39	2	24040397
Pubmed	PirB regulates asymmetries in hippocampal circuitry.	LILRA1 LILRB1	1.83e-05	6	39	2	28594961
Pubmed	The p75 receptor mediates axon growth inhibition through an association with PIR-B.	LILRA1 LILRB1	1.83e-05	6	39	2	21881600
Pubmed	Paired immunoglobulin-like receptor A is an intrinsic, self-limiting suppressor of IL-5-induced eosinophil development.	LILRA1 LILRB1	1.83e-05	6	39	2	24212998
Pubmed	Glatiramer Acetate Enhances Myeloid-Derived Suppressor Cell Function via Recognition of Paired Ig-like Receptor B.	LILRA1 LILRB1	1.83e-05	6	39	2	30068593
Pubmed	Impaired dendritic cell maturation and increased T(H)2 responses in PIR-B(-/-) mice.	LILRA1 LILRB1	1.83e-05	6	39	2	12021780
Pubmed	Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning.	DLG3 NETO1	2.56e-05	7	39	2	19243221
Pubmed	Alternative mRNA splicing creates transcripts encoding soluble proteins from most LILR genes.	LILRA1 LILRB1	2.56e-05	7	39	2	19658091
Pubmed	LOTUS suppresses amyloid β-induced dendritic spine elimination through the blockade of amyloid β binding to PirB.	LILRA1 LILRB1	2.56e-05	7	39	2	36510132
Pubmed	Augmented TLR9-induced Btk activation in PIR-B-deficient B-1 cells provokes excessive autoantibody production and autoimmunity.	LILRA1 LILRB1	2.56e-05	7	39	2	19687229
Pubmed	Differential expression of leukocyte immunoglobulin-like receptors on cord-blood-derived human mast cell progenitors and mature mast cells.	LILRA1 LILRB1	2.56e-05	7	39	2	17998301
Pubmed	PirB restricts ocular-dominance plasticity in visual cortex.	LILRA1 LILRB1	2.56e-05	7	39	2	16917027
Pubmed	The Nogo-B-PirB axis controls macrophage-mediated vascular remodeling.	LILRA1 LILRB1	2.56e-05	7	39	2	24278366
Pubmed	A dual activation and inhibition role for the paired immunoglobulin-like receptor B in eosinophils.	LILRA1 LILRB1	2.56e-05	7	39	2	18316626
Pubmed	Macrophage Paired Immunoglobulin-Like Receptor B Deficiency Promotes Peripheral Atherosclerosis in Apolipoprotein E-Deficient Mice.	LILRA1 LILRB1	2.56e-05	7	39	2	35321392
Pubmed	Oligodendrocyte-myelin glycoprotein and Nogo negatively regulate activity-dependent synaptic plasticity.	LILRA1 LILRB1	2.56e-05	7	39	2	20844138
Pubmed	Differential localization of septins in the mouse brain.	SEPTIN5 SEPTIN4	2.56e-05	7	39	2	11064363
Pubmed	NADPH oxidase gp91phox contributes to RANKL-induced osteoclast differentiation by upregulating NFATc1.	LILRA1 LILRB1	2.56e-05	7	39	2	27897222
Pubmed	Paired Ig-like receptors bind to bacteria and shape TLR-mediated cytokine production.	LILRA1 LILRB1	2.56e-05	7	39	2	17371981
Pubmed	Transcriptional activation of the Pirb gene in B cells by PU.1 and Runx3.	LILRA1 LILRB1	2.56e-05	7	39	2	21555536
Pubmed	Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development.	LILRA1 LILRB1	3.42e-05	8	39	2	22660330
Interaction	SEPTIN4 interactions	PRKN TIA1 SEPTIN5 SEPTIN4	8.43e-07	38	39	4	int:SEPTIN4
Interaction	TIA1 interactions	GEMIN4 PRKN TIA1 SEPTIN5 SEPTIN4 ATP2A2 RPH3A	8.64e-07	275	39	7	int:TIA1
Interaction	LILRA3 interactions	LILRA1 LILRA3 LILRB1	1.09e-06	11	39	3	int:LILRA3
Interaction	LILRA1 interactions	LILRA1 LILRA3	3.65e-06	2	39	2	int:LILRA1
Interaction	SEPTIN5 interactions	PRKN TIA1 SEPTIN5 SEPTIN4	6.16e-06	62	39	4	int:SEPTIN5
Interaction	SEPTIN6 interactions	PRKN TIA1 SEPTIN5 SEPTIN4	2.48e-05	88	39	4	int:SEPTIN6
Interaction	SLC2A3 interactions	PRKN TIA1 HSPA4	4.20e-05	35	39	3	int:SLC2A3
Interaction	RPH3A interactions	PRKN TIA1 RPH3A	5.84e-05	39	39	3	int:RPH3A
Cytoband	19q13.4	LILRA1 LILRA3 LILRB1	4.29e-05	79	39	3	19q13.4
GeneFamily	CD molecules\|Activating leukocyte immunoglobulin like receptors	LILRA1 LILRA3	3.21e-05	6	27	2	1181
GeneFamily	Septins	SEPTIN5 SEPTIN4	1.66e-04	13	27	2	732
Disease	leukocyte immunoglobulin-like receptor subfamily B member 1 measurement	LILRA1 LILRB1	1.50e-04	15	36	2	EFO_0008208
Disease	Lewy body dementia (is_marker_for)	PRKN SEPTIN4	2.44e-04	19	36	2	DOID:12217 (is_marker_for)
Disease	Autosomal Dominant Parkinsonism	PRKN ATP1A3	5.36e-04	28	36	2	C0752098
Disease	Autosomal Dominant Juvenile Parkinson Disease	PRKN ATP1A3	5.36e-04	28	36	2	C0752097
Disease	PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE	PRKN ATP1A3	5.36e-04	28	36	2	C1868675
Disease	Parkinsonism, Experimental	PRKN ATP1A3	5.36e-04	28	36	2	C0752101
Disease	Autosomal Recessive Parkinsonism	PRKN ATP1A3	5.36e-04	28	36	2	C0752100
Disease	Familial Juvenile Parkinsonism	PRKN ATP1A3	5.36e-04	28	36	2	C0752104
Disease	Ramsay Hunt Paralysis Syndrome	PRKN ATP1A3	5.36e-04	28	36	2	C0242423
Disease	Ventricular Dysfunction, Left	ATP1A3 ATP2A2	6.16e-04	30	36	2	C0242698
Disease	Parkinsonism, Juvenile	PRKN ATP1A3	6.16e-04	30	36	2	C0752105
Disease	esophageal carcinoma	ATP2A2 PLCE1	6.16e-04	30	36	2	EFO_0002916
Disease	Parkinsonian Disorders	PRKN ATP1A3	6.16e-04	30	36	2	C0242422
Disease	colorectal cancer	PRKN XRRA1 EIF3H HSPA4 SBF2	7.88e-04	604	36	5	MONDO_0005575
Disease	Mood Disorders	DLG3 ATP2A2 HSPA4	1.13e-03	168	36	3	C0525045
Disease	interleukin 7 measurement	LILRA1 LILRB1	1.39e-03	45	36	2	EFO_0008189
Disease	interleukin 13 measurement	LILRA1 LILRB1	1.39e-03	45	36	2	EFO_0008171
Disease	major depressive episode	PRKN FREM3	1.51e-03	47	36	2	EFO_0007634
Disease	polyp of colon	XRRA1 EIF3H	2.14e-03	56	36	2	MONDO_0021400
Disease	smoking status measurement	RHOT2 ATP23 EIF3H REV3L RPH3A SORL1	2.58e-03	1160	36	6	EFO_0006527
Disease	Bipolar Disorder	TPO DLG3 ATP1A3 HSPA4	2.64e-03	477	36	4	C0005586
Disease	Parkinson's disease (is_marker_for)	PRKN SEPTIN4	3.04e-03	67	36	2	DOID:14330 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
CFPFPQHTEDDADFD	EIF3H	81	O15372
CKFDHIEVRDGPFGF	NETO1	96	Q8TDF5
IKDHFCPFENQFHTE	C8orf76	361	Q96K31
DEVFESCFNDHEPFG	ATP23	206	Q9Y6H3
FDEVLVNHFCEEFGK	HSPA4	236	P34932
EIKQSPDEFCHSDFE	KCTD16	126	Q68DU8
EFALNCEFVPVEFHE	SBF2	1331	Q86WG5
KCGFPESVENGDFVH	TPO	741	P07202
EQSDFHEKFAGGDVC	TUBGCP5	656	Q96RT8
DDEKEFIHFPVCEGT	MSANTD3	151	Q96H12
SKPDVHFFHCDEVEA	EPS8L2	146	Q9H6S3
DDEVFFGPFGHKERC	GTSE1	31	Q9NYZ3
HFLQCKEDNPDFEGV	ATP2A2	871	P16615
KEDNPDFEGVDCAIF	ATP2A2	876	P16615
SPDEEGFCSGKHFTE	DOCK6	1666	Q96HP0
NDDLISEFPHKFGSC	DLG3	641	Q92796
CKHPEDSENNFFEGF	DNAH14	3306	Q0VDD8
PEEQFPKGFAFDCDD	ATP1A3	551	P13637
FDGFILCKEGEDEHP	LILRA3	151	Q8N6C8
HKGVEPQEDQFTFYC	FREM3	1156	P0C091
YHNPAGFNCKDETEF	RTRAF	11	Q9Y224
SQDPEFHKVCDEFGF	SORL1	1316	Q92673
SVCDEDKFGHNEFIG	RPH3A	481	Q9Y2J0
EHFGIKIYQFPDCDS	SEPTIN4	311	O43236
DKFGIHVYQFPECDS	SEPTIN5	211	Q99719
AEFFFKCGAHPTSDK	PRKN	206	O60260
FGSFILCKEGEDEHP	LILRA1	151	O75019
FDGFSLCKEGEDEHP	LILRB1	151	Q8NHL6
DEELNAFQKSCFGHP	RHOT2	206	Q8IXI1
FLSHFEDFPDNCDDV	PLCE1	296	Q9P212
EIFNNPCFEEEEHFK	PITRM1	686	Q5JRX3
EGQHSKPFKEFVEAC	STK25	236	O00506
ESSFLNFHDSDCEPK	TTC13	91	Q8NBP0
ENKTPTDGFIDCHFG	REV3L	886	O60673
PEKSHYEFNDTGNCF	ZNF782	266	Q6ZMW2
EDFPEESQLHQCGFK	ZCWPW2	76	Q504Y3
CFHEIEKDIHGFEFQ	ZNF468	86	Q5VIY5
FGHFLEFMDEFCQEP	XRRA1	771	Q6P2D8
DTAGNDPYCFVEFHE	TIA1	41	P31483
SFFEGHFKCEVPATL	GEMIN4	776	P57678