Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsemaphorin receptor activity

PLXNA3 PLXNA1 PLXNA2

4.81e-0712273GO:0017154
GeneOntologyBiologicalProcessolfactory nerve formation

PLXNA3 PLXNA1

1.65e-062272GO:0021628
GeneOntologyBiologicalProcessolfactory nerve morphogenesis

PLXNA3 PLXNA1

4.95e-063272GO:0021627
GeneOntologyBiologicalProcessgonadotrophin-releasing hormone neuronal migration to the hypothalamus

PLXNA3 PLXNA1

3.45e-057272GO:0021828
GeneOntologyBiologicalProcesshypothalamic tangential migration using cell-axon interactions

PLXNA3 PLXNA1

3.45e-057272GO:0021856
GeneOntologyBiologicalProcesssemaphorin-plexin signaling pathway

PLXNA3 PLXNA1 PLXNA2

4.24e-0552273GO:0071526
GeneOntologyBiologicalProcessolfactory nerve development

PLXNA3 PLXNA1

4.60e-058272GO:0021553
GeneOntologyBiologicalProcesshypothalamus cell migration

PLXNA3 PLXNA1

5.91e-059272GO:0021855
GeneOntologyBiologicalProcesshypothalamus gonadotrophin-releasing hormone neuron differentiation

PLXNA3 PLXNA1

5.91e-059272GO:0021886
GeneOntologyBiologicalProcesshypothalamus gonadotrophin-releasing hormone neuron development

PLXNA3 PLXNA1

5.91e-059272GO:0021888
GeneOntologyBiologicalProcesspositive regulation of neurogenesis

PLXNA3 LIG4 KALRN PLXNA1 PLXNA2

8.56e-05354275GO:0050769
GeneOntologyBiologicalProcesscranial nerve formation

PLXNA3 PLXNA1

9.01e-0511272GO:0021603
GeneOntologyBiologicalProcesshypothalamus cell differentiation

PLXNA3 PLXNA1

1.49e-0414272GO:0021979
GeneOntologyBiologicalProcesspositive regulation of nervous system development

PLXNA3 LIG4 KALRN PLXNA1 PLXNA2

1.86e-04418275GO:0051962
GeneOntologyBiologicalProcessnerve development

PLXNA3 SULF2 PLXNA1

3.83e-04109273GO:0021675
GeneOntologyBiologicalProcesspositive regulation of axonogenesis

PLXNA3 PLXNA1 PLXNA2

4.37e-04114273GO:0050772
GeneOntologyBiologicalProcessregulation of neurogenesis

PLXNA3 LIG4 KALRN PLXNA1 PLXNA2

4.88e-04515275GO:0050767
GeneOntologyBiologicalProcessregulation of cell morphogenesis

PLXNA3 KALRN PLXNA1 PLXNA2

6.06e-04302274GO:0022604
GeneOntologyBiologicalProcessforebrain neuron development

PLXNA3 PLXNA1

7.02e-0430272GO:0021884
GeneOntologyBiologicalProcesshypothalamus development

PLXNA3 PLXNA1

7.50e-0431272GO:0021854
GeneOntologyBiologicalProcesscranial nerve morphogenesis

PLXNA3 PLXNA1

7.99e-0432272GO:0021602
GeneOntologyBiologicalProcessregulation of GTPase activity

PLXNA3 KALRN PLXNA1 PLXNA2

8.93e-04335274GO:0043087
GeneOntologyBiologicalProcesspositive regulation of cell development

PLXNA3 LIG4 KALRN PLXNA1 PLXNA2

1.08e-03614275GO:0010720
GeneOntologyBiologicalProcessregulation of cell shape

PLXNA3 PLXNA1 PLXNA2

1.15e-03159273GO:0008360
GeneOntologyBiologicalProcessregulation of nervous system development

PLXNA3 LIG4 KALRN PLXNA1 PLXNA2

1.17e-03625275GO:0051960
GeneOntologyCellularComponentsemaphorin receptor complex

PLXNA3 PLXNA1 PLXNA2

5.45e-0713273GO:0002116
DomainPlexin_cytopl

PLXNA3 PLXNA1 PLXNA2

2.52e-079283PF08337
DomainPlexin_cytoplasmic_RasGAP_dom

PLXNA3 PLXNA1 PLXNA2

2.52e-079283IPR013548
DomainPlexin

PLXNA3 PLXNA1 PLXNA2

2.52e-079283IPR031148
DomainIPT

PLXNA3 PLXNA1 PLXNA2

8.62e-0627283SM00429
DomainTIG

PLXNA3 PLXNA1 PLXNA2

1.32e-0531283PF01833
DomainSEMA

PLXNA3 PLXNA1 PLXNA2

1.32e-0531283PS51004
DomainSema

PLXNA3 PLXNA1 PLXNA2

1.32e-0531283SM00630
DomainSemap_dom

PLXNA3 PLXNA1 PLXNA2

1.32e-0531283IPR001627
DomainSema

PLXNA3 PLXNA1 PLXNA2

1.32e-0531283PF01403
DomainPlexin_repeat

PLXNA3 PLXNA1 PLXNA2

1.45e-0532283IPR002165
DomainPSI

PLXNA3 PLXNA1 PLXNA2

1.45e-0532283PF01437
DomainIPT

PLXNA3 PLXNA1 PLXNA2

1.45e-0532283IPR002909
DomainPSI

PLXNA3 PLXNA1 PLXNA2

3.84e-0544283IPR016201
DomainPSI

PLXNA3 PLXNA1 PLXNA2

4.39e-0546283SM00423
DomainRho_GTPase_activation_prot

PLXNA3 PLXNA1 PLXNA2

3.04e-0488283IPR008936
DomainIg_E-set

PLXNA3 PLXNA1 PLXNA2

4.97e-04104283IPR014756
Domain-

PLXNA3 PLXNA1 PLXNA2 ARPC1A

1.45e-033332842.130.10.10
DomainWD40/YVTN_repeat-like_dom

PLXNA3 PLXNA1 PLXNA2 ARPC1A

1.48e-03335284IPR015943
DomainDH_1

KALRN FARP1

4.00e-0363282PS00741
DomainRhoGEF

KALRN FARP1

4.64e-0368282SM00325
DomainDH_2

KALRN FARP1

4.91e-0370282PS50010
DomainRhoGEF

KALRN FARP1

4.91e-0370282PF00621
DomainDH-domain

KALRN FARP1

5.05e-0371282IPR000219
Domain-

KALRN FARP1

5.05e-03712821.20.900.10
Domain-

PLXNA3 KALRN PLXNA1 PLXNA2

1.64e-026632842.60.40.10
Domain-

ZNF438 ZSCAN1 ZNF443 ZNF180

1.77e-026792843.30.160.60
Domainzf-C2H2

ZNF438 ZSCAN1 ZNF443 ZNF180

1.90e-02693284PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF438 ZSCAN1 ZNF443 ZNF180

1.90e-02694284IPR013087
PathwayREACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION

PLXNA3 PLXNA1 PLXNA2

2.38e-079213MM15030
PathwayREACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION

PLXNA3 PLXNA1 PLXNA2

1.03e-0614213M7578
PathwayREACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION

PLXNA3 PLXNA1 PLXNA2

1.03e-0614213MM15029
PathwayREACTOME_CRMPS_IN_SEMA3A_SIGNALING

PLXNA3 PLXNA1 PLXNA2

1.28e-0615213MM15031
PathwayREACTOME_CRMPS_IN_SEMA3A_SIGNALING

PLXNA3 PLXNA1 PLXNA2

1.58e-0616213M8245
PathwayREACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION

PLXNA3 PLXNA1 PLXNA2

1.58e-0616213M16498
PathwayREACTOME_NERVOUS_SYSTEM_DEVELOPMENT

PLXNA3 KALRN PLXNA1 PLXNA2 ARPC1A

3.34e-05261215MM15676
PathwayREACTOME_SEMAPHORIN_INTERACTIONS

PLXNA3 PLXNA1 PLXNA2

5.67e-0551213MM14967
PathwayREACTOME_SEMAPHORIN_INTERACTIONS

PLXNA3 PLXNA1 PLXNA2

1.12e-0464213M7923
PathwayREACTOME_OTHER_SEMAPHORIN_INTERACTIONS

PLXNA1 PLXNA2

3.56e-0419212M10959
PathwayREACTOME_DEVELOPMENTAL_BIOLOGY

PLXNA3 KALRN PLXNA1 PLXNA2 ARPC1A

7.11e-04502215MM14537
PathwayKEGG_AXON_GUIDANCE

PLXNA3 PLXNA1 PLXNA2

8.83e-04129213M5539
PathwayREACTOME_NERVOUS_SYSTEM_DEVELOPMENT

PLXNA3 KALRN PLXNA1 PLXNA2 ARPC1A

1.31e-03575215M29853
PathwayREACTOME_EPHB_MEDIATED_FORWARD_SIGNALING

KALRN ARPC1A

1.36e-0337212MM15022
PathwayREACTOME_EPHB_MEDIATED_FORWARD_SIGNALING

KALRN ARPC1A

1.76e-0342212M27308
PathwayWP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER

PLXNA1 PLXNA2

2.89e-0354212M42568
PathwayREACTOME_DEVELOPMENTAL_BIOLOGY

PLXNA3 FLG KALRN PLXNA1 PLXNA2 ARPC1A MAMLD1

3.55e-031432217M509
Pubmed

Identification of plexin family molecules in mice.

PLXNA3 PLXNA1 PLXNA2

4.67e-1032838806646
Pubmed

Differential expression of plexin-A subfamily members in the mouse nervous system.

PLXNA3 PLXNA1 PLXNA2

4.67e-10328311241833
Pubmed

Determination of cell adhesion sites of neuropilin-1.

PLXNA3 PLXNA1 PLXNA2

1.87e-09428310725340
Pubmed

Chromosome assignment of four plexin A genes (Plxna1, Plxna2, Plxna3, Plxna4) in mouse, rat, Syrian hamster and Chinese hamster.

PLXNA3 PLXNA1 PLXNA2

1.87e-09428311306810
Pubmed

PlexinA polymorphisms mediate the developmental trajectory of human corpus callosum microstructure.

PLXNA3 PLXNA1 PLXNA2

1.87e-09428325518740
Pubmed

A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor.

PLXNA3 PLXNA1 PLXNA2

1.87e-0942838570614
Pubmed

Semaphorin 5A inhibits synaptogenesis in early postnatal- and adult-born hippocampal dentate granule cells.

PLXNA3 PLXNA1 PLXNA2

4.67e-09528325313870
Pubmed

Expression and function of semaphorin 3A and its receptors in human monocyte-derived macrophages.

PLXNA3 PLXNA1 PLXNA2

9.33e-09628319480842
Pubmed

Increased proximal bifurcation of CA1 pyramidal apical dendrites in sema3A mutant mice.

PLXNA3 PLXNA1 PLXNA2

1.63e-08728319655386
Pubmed

Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors.

PLXNA3 PLXNA1 PLXNA2

1.63e-08728310520994
Pubmed

Semaphorin-6A controls guidance of corticospinal tract axons at multiple choice points.

PLXNA3 PLXNA1 PLXNA2

1.63e-08728319063725
Pubmed

The expression of plexins during mouse embryogenesis.

PLXNA3 PLXNA1 PLXNA2

2.61e-08828315661641
Pubmed

Integration of opposing semaphorin guidance cues in cortical axons.

PLXNA3 PLXNA1 PLXNA2

2.61e-08828322368082
Pubmed

The role of neuropilins in cell signalling.

PLXNA3 PLXNA1 PLXNA2

3.91e-08928319909241
Pubmed

PlexinA2 and semaphorin signaling during cardiac neural crest development.

PLXNA3 PLXNA1 PLXNA2

3.91e-08928311688557
Pubmed

Plexin A3 and plexin A4 convey semaphorin signals during facial nerve development.

PLXNA3 PLXNA1 PLXNA2

5.59e-081028318804103
Pubmed

Transmembrane semaphorin signalling controls laminar stratification in the mammalian retina.

PLXNA3 PLXNA1 PLXNA2

1.02e-071228321270798
Pubmed

Functional loss of semaphorin 3C and/or semaphorin 3D and their epistatic interaction with ret are critical to Hirschsprung disease liability.

PLXNA3 PLXNA1 PLXNA2

1.02e-071228325839327
Pubmed

PLXNA1 and PLXNA3 cooperate to pattern the nasal axons that guide gonadotropin-releasing hormone neurons.

PLXNA3 PLXNA1 PLXNA2

1.02e-071228331690636
Pubmed

Deletion of Sema3a or plexinA1/plexinA3 causes defects in sensory afferent projections of statoacoustic ganglion neurons.

PLXNA3 PLXNA1 PLXNA2

1.02e-071228323991118
Pubmed

On and off retinal circuit assembly by divergent molecular mechanisms.

PLXNA3 PLXNA1 PLXNA2

1.02e-071228324179230
Pubmed

Transcriptome profiling reveals expression signatures of cranial neural crest cells arising from different axial levels.

PLXNA3 PLXNA1 PLXNA2

1.02e-071228328407732
Pubmed

Functional assembly of accessory optic system circuitry critical for compensatory eye movements.

PLXNA3 PLXNA1 PLXNA2

1.33e-071328325959730
Pubmed

Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.

PLXNA3 PLXNA1 PLXNA2

1.33e-071328310520995
Pubmed

Plexin signaling via off-track and rho family GTPases.

PLXNA3 PLXNA1 PLXNA2

1.33e-071328311604131
Pubmed

Semaphorin3A, Neuropilin-1, and PlexinA1 are required for lymphatic valve formation.

PLXNA3 PLXNA1 PLXNA2

1.33e-071328322723296
Pubmed

A midline switch of receptor processing regulates commissural axon guidance in vertebrates.

PLXNA3 PLXNA1 PLXNA2

1.69e-071428320159958
Pubmed

Allocation of paraventricular and supraoptic neurons requires Sim1 function: a role for a Sim1 downstream gene PlexinC1.

PLXNA3 PLXNA1 PLXNA2

2.60e-071628317356169
Pubmed

Expression of the semaphorins Sema 3D and Sema 3F in the developing parathyroid and thymus.

PLXNA3 PLXNA1 PLXNA2

2.60e-071628318489001
Pubmed

Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections.

PLXNA3 PLXNA1 PLXNA2

3.15e-071728311683995
Pubmed

Semaphorin signaling facilitates cleft formation in the developing salivary gland.

PLXNA3 PLXNA1 PLXNA2

3.15e-071728317626059
Pubmed

Class 5 transmembrane semaphorins control selective Mammalian retinal lamination and function.

PLXNA3 PLXNA1 PLXNA2

6.15e-072128321835343
Pubmed

Plexin/neuropilin complexes mediate repulsion by the axonal guidance signal semaphorin 3A.

PLXNA1 PLXNA2

6.25e-07228210781943
Pubmed

A semaphorin code defines subpopulations of spinal motor neurons during mouse development.

PLXNA3 PLXNA1 PLXNA2

9.35e-072428315869472
Pubmed

A radial axis defined by semaphorin-to-neuropilin signaling controls pancreatic islet morphogenesis.

PLXNA3 PLXNA1 PLXNA2

9.35e-072428328893946
Pubmed

Expression of Robo/Slit and Semaphorin/Plexin/Neuropilin family members in the developing hypothalamic paraventricular and supraoptic nuclei.

PLXNA3 PLXNA1 PLXNA2

1.51e-062828318617019
Pubmed

Structural Basis for Plexin Activation and Regulation.

PLXNA1 PLXNA2

1.87e-06328227397516
Pubmed

Fyn-dependent phosphorylation of PlexinA1 and PlexinA2 at conserved tyrosines is essential for zebrafish eye development.

PLXNA1 PLXNA2

1.87e-06328229091353
Pubmed

Repulsive and attractive semaphorins cooperate to direct the navigation of cardiac neural crest cells.

PLXNA1 PLXNA2

1.87e-06328218625214
Pubmed

Plexins promote Hedgehog signaling through their cytoplasmic GAP activity.

PLXNA1 PLXNA2

1.87e-06328236169302
Pubmed

Myeloid translocation gene 16b is a dual A-kinase anchoring protein that interacts selectively with plexins in a phospho-regulated manner.

PLXNA3 PLXNA1

1.87e-06328220138877
Pubmed

Semaphorin-plexin signalling genes associated with human breast tumourigenesis.

PLXNA3 PLXNA2

3.75e-06428221925246
Pubmed

TrkB-dependent EphrinA reverse signaling regulates callosal axon fasciculate growth downstream of Neurod2/6.

PLXNA3 PLXNA1 PLXNA2

7.40e-064728335462405
Pubmed

An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina.

PLXNA3 PLXNA1 PLXNA2

1.01e-055228326633812
Pubmed

Semaphorin-5B Controls Spiral Ganglion Neuron Branch Refinement during Development.

PLXNA3 PLXNA1

3.42e-051128231209173
Pubmed

Class 3 semaphorins negatively regulate dermal lymphatic network formation.

PLXNA1 PLXNA2

3.42e-051128226319580
Pubmed

Optic chiasm presentation of Semaphorin6D in the context of Plexin-A1 and Nr-CAM promotes retinal axon midline crossing.

PLXNA1 PLXNA2

7.45e-051628222632726
Pubmed

SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse.

PLXNA1 ARPC1A

8.44e-051728231171447
Pubmed

PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development.

PLXNA1 PLXNA2

1.06e-041928215239958
Pubmed

PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.

PLXNA3 PLXNA1 PLXNA2

1.14e-0411728317145500
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

THSD7B ALMS1 PLXNA2

1.56e-0413028312421765
Pubmed

Zic2-dependent axon midline avoidance controls the formation of major ipsilateral tracts in the CNS.

PLXNA1 PLXNA2

1.56e-042328224360543
Pubmed

Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV.

LIG4 CDK11B

1.85e-042528215385968
Pubmed

The structural role of radial glial endfeet in confining spinal motor neuron somata is controlled by the Reelin and Notch pathways.

PLXNA1 PLXNA2

2.01e-042628223988635
Pubmed

Slit and Semaphorin signaling governed by Islet transcription factors positions motor neuron somata within the neural tube.

PLXNA1 PLXNA2

2.17e-042728225843547
Pubmed

Molecular mapping of developing dorsal horn-enriched genes by microarray and dorsal/ventral subtractive screening.

RUNX1T1 PLXNA2

3.05e-043228216516881
Pubmed

The DNA sequence and analysis of human chromosome 13.

LIG4 MTMR6 FARP1

3.44e-0417028315057823
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

ZNF438 PLXNA3 PLXNA1 PLXNA2 ZNF180

4.21e-0480828520412781
Pubmed

Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.

FARP1 PLXNA1

5.53e-044328221116278
Pubmed

Plk4 Promotes Cancer Invasion and Metastasis through Arp2/3 Complex Regulation of the Actin Cytoskeleton.

ALMS1 ARPC1A

6.89e-044828227872092
InteractionSEMA5A interactions

PLXNA3 PLXNA1 PLXNA2

8.38e-087283int:SEMA5A
InteractionSEMA5B interactions

PLXNA3 PLXNA1 PLXNA2

1.08e-0615283int:SEMA5B
InteractionDEFA5 interactions

FRAS1 SULF2 PLXNA1 PLXNA2

2.57e-0670284int:DEFA5
InteractionSEMA6D interactions

PLXNA3 PLXNA1 PLXNA2

4.18e-0623283int:SEMA6D
InteractionST8SIA4 interactions

PLXNA3 FRAS1 PLXNA1 PLXNA2

5.33e-0684284int:ST8SIA4
InteractionIL5RA interactions

PLXNA3 FRAS1 SULF2 PLXNA1

2.49e-05124284int:IL5RA
InteractionGPIHBP1 interactions

PLXNA3 FRAS1 SULF2 PLXNA2

3.28e-05133284int:GPIHBP1
InteractionSCGB1D1 interactions

PLXNA3 FRAS1 PLXNA1 PLXNA2

3.28e-05133284int:SCGB1D1
InteractionSUSD4 interactions

FRAS1 PLXNA1 PLXNA2

4.51e-0550283int:SUSD4
InteractionEDDM3B interactions

PLXNA3 SULF2 PLXNA2

7.79e-0560283int:EDDM3B
InteractionC1orf54 interactions

PLXNA3 SULF2 PLXNA1 PLXNA2

7.97e-05167284int:C1orf54
InteractionLGALS1 interactions

FRAS1 SLC39A10 LCTL PLXNA1 PLXNA2

8.47e-05332285int:LGALS1
InteractionSEMA6A interactions

PLXNA3 PLXNA1 PLXNA2

9.02e-0563283int:SEMA6A
InteractionPTPRK interactions

PLXNA3 FRAS1 PLXNA1 PLXNA2

9.99e-05177284int:PTPRK
InteractionCA6 interactions

PLXNA3 PLXNA1 PLXNA2

1.18e-0469283int:CA6
InteractionFIBIN interactions

PLXNA3 FLG PLXNA1

1.29e-0471283int:FIBIN
InteractionIGFL3 interactions

FRAS1 SULF2 PLXNA2

1.52e-0475283int:IGFL3
InteractionTAFAZZIN interactions

PLXNA3 FRAS1 PLXNA1 PLXNA2

1.82e-04207284int:TAFAZZIN
InteractionOS9 interactions

FRAS1 SULF2 PLXNA1 PLXNA2

2.26e-04219284int:OS9
InteractionSIRPD interactions

PLXNA3 FRAS1 PLXNA1

2.28e-0486283int:SIRPD
InteractionFBXO2 interactions

PLXNA3 FRAS1 SULF2 PLXNA1 PLXNA2

2.30e-04411285int:FBXO2
InteractionSPANXN2 interactions

ZNF438 SULF2 ALMS1

3.05e-0495283int:SPANXN2
InteractionGGH interactions

PLXNA3 LIG4 FRAS1 PLXNA1

3.36e-04243284int:GGH
InteractionDEFA1 interactions

SULF2 PLXNA1 PLXNA2

3.55e-04100283int:DEFA1
InteractionGPHA2 interactions

FRAS1 PLXNA2

5.48e-0425282int:GPHA2
InteractionLYZL1 interactions

PLXNA3 FRAS1 PLXNA1

5.76e-04118283int:LYZL1
InteractionCEACAM8 interactions

PLXNA3 FRAS1 SULF2

5.90e-04119283int:CEACAM8
InteractionCBLN4 interactions

PLXNA3 FRAS1 PLXNA1

7.14e-04127283int:CBLN4
InteractionPLXND1 interactions

PLXNA3 PLXNA1

8.44e-0431282int:PLXND1
InteractionHLA-DQA1 interactions

PLXNA3 PLXNA1 PLXNA2

8.52e-04135283int:HLA-DQA1
InteractionTMPRSS4 interactions

PLXNA3 SULF2 PLXNA1 PLXNA2

8.81e-04314284int:TMPRSS4
CytobandEnsembl 112 genes in cytogenetic band chr3q21

KALRN PLXNA1

4.30e-03160282chr3q21
CytobandXq28

PLXNA3 MAMLD1

5.17e-03176282Xq28
CytobandEnsembl 112 genes in cytogenetic band chrXq28

PLXNA3 MAMLD1

7.48e-03213282chrXq28
GeneFamilyPlexins

PLXNA3 PLXNA1 PLXNA2

9.68e-089203683
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

KALRN FARP1

2.39e-0366202722
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF438 ZSCAN1 ZNF443 ZNF180

7.19e-0371820428
ToppCellRV-09._Endothelium_I|World / Chamber and Cluster_Paper

SULF2 RUNX1T1 KALRN PLXNA2

6.20e-06193284e3fa47e2c7cd8a5b69186711c57751f2296de8ae
ToppCellLV-09._Endothelium_I|World / Chamber and Cluster_Paper

SULF2 RUNX1T1 KALRN PLXNA2

6.46e-0619528419e0a6c3eae1615aaa39767300acd937dfcb2a7f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SULF2 RUNX1T1 KALRN

1.26e-04156283ea9223bb6450b22df11efa1705ab72dab005244a
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SULF2 RUNX1T1 KALRN

1.26e-04156283586b5509074c4cc359e9e31a968c2ded71c994ca
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-late_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXNA3 PSAPL1 KALRN

1.48e-041652830edd56e8d14eaeced9882dd9206ea93e8f402e8d
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXNA3 PSAPL1 KALRN

1.48e-04165283fa3aadfff6fb1e7f142db333c60c2cba02b17e6c
ToppCellEndothelial-B-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

SULF2 RUNX1T1 KALRN

1.59e-041692838889c9e8af1ab0b093d57b69abd80b59b3461be9
ToppCelldroplet-Marrow-BM-1m-Lymphocytic-plasma_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SULF2 SLC39A10 PLXNA1

1.82e-0417728326bad614560609d318bfc9c235a698bca4e1c22c
ToppCellfacs-Lung-24m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ALMS1 DDX60 ZNF180

1.92e-04180283d33bb00f2b7d07dda9015cb8eafd742c2b2e9ace
ToppCellCOVID-19-Heart-EC_3|COVID-19 / Disease (COVID-19 only), tissue and cell type

SULF2 RUNX1T1 KALRN

2.01e-04183283ff95382cfed592190d0636d2b750328471f82e0d
ToppCellE16.5-samps-Mesenchymal-Myofibroblast|E16.5-samps / Age Group, Lineage, Cell class and subclass

SULF2 RUNX1T1 PLXNA2

2.11e-04186283e044b3428b7eacfdc72d0f57cdabaa1de04c74cd
ToppCellAdult-Endothelial-endothelial_cell_of_lymph_vessel-D175|Adult / Lineage, Cell type, age group and donor

SULF2 RUNX1T1 KALRN

2.14e-041872831e52d3d9d664c813d859b5b75e4c07b218818f95
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein|Children_(3_yrs) / Lineage, Cell type, age group and donor

SULF2 RUNX1T1 KALRN

2.14e-04187283e35716f8b482be3bf5ab79f087a9caf67a9d197a
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)|Striatum / BrainAtlas - Mouse McCarroll V32

FRAS1 RUNX1T1 ZNF180

2.18e-04188283e34ea7014c5a059a7db38f78bd903cf02616ddd3
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

SULF2 RUNX1T1 KALRN

2.18e-041882832db80767903703e7e0a1a37c598f7877a909ee94
ToppCellCOVID-19-lung-Vein_EC|lung / Disease (COVID-19 only), tissue and cell type

SULF2 RUNX1T1 KALRN

2.18e-04188283d582b76fc2faac526c9bf97503041129e1a6a211
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel|Children_(3_yrs) / Lineage, Cell type, age group and donor

SULF2 RUNX1T1 KALRN

2.18e-04188283c2805232618a7b6f844d34e37ad458a9923dbfe1
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

SULF2 RUNX1T1 KALRN

2.18e-04188283aeecbc057dc823f8fcea8a98f18d213bacc7f4db
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

RUNX1T1 KALRN MAMLD1

2.25e-04190283048b581e3f7ea9fc2f87c0532974bba85c7292c2
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

RUNX1T1 KALRN MAMLD1

2.25e-041902831121eb607a984c59fbffe7220837fc178745aa55
ToppCellAdult-Endothelial-endothelial_cell_of_lymph_vessel|Adult / Lineage, Cell type, age group and donor

SULF2 RUNX1T1 KALRN

2.25e-0419028391bf3b7e9148589757436a53a4f58e0ebfe54400
ToppCellCOVID-19-Heart-EC_3|Heart / Disease (COVID-19 only), tissue and cell type

SULF2 KALRN MAMLD1

2.25e-0419028378e7c502b0450c0b37652b1896a2a752fd8a2111
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RUNX1T1 KALRN MAMLD1

2.28e-04191283a6c57627077fa980b7ec1d3894b5f31bfb11b738
ToppCellRA-09._Endothelium_I|World / Chamber and Cluster_Paper

SULF2 KALRN PLXNA2

2.28e-04191283c8a0c2af119bc34a8f694a7d30642f28002c84b9
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RUNX1T1 KALRN MAMLD1

2.28e-041912838f6d592edc32fdb901af30501d4360512334e8c2
ToppCellRA-09._Endothelium_I|RA / Chamber and Cluster_Paper

SULF2 KALRN PLXNA2

2.32e-041922838a1b1c3e83a68ad74f8f4eb00455c9e41aa57cfc
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SULF2 RUNX1T1 KALRN

2.32e-04192283c0e59e642b42c055cf73d029cf54d07d9b719359
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7B FBXL21P PLXNA1

2.32e-04192283342842378c20267c5044bdd622515e8b9f895623
ToppCelldroplet-Lung-30m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RUNX1T1 FBXL21P FARP1

2.35e-0419328364edc1d6fb0fe117767d494cf4a5723bf8be2804
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SULF2 RUNX1T1 KALRN

2.35e-0419328352e918884877b6659cdca0496390e440f73694a9
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SULF2 RUNX1T1 KALRN

2.39e-04194283e55dc30e200c9f576804acb642175eb4fa9146b5
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

RUNX1T1 KALRN FARP1

2.39e-04194283b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCellRV-09._Endothelium_I|RV / Chamber and Cluster_Paper

SULF2 KALRN PLXNA2

2.39e-041942837b408096e717f2327c12aea35a8d5fc4621d3b06
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RUNX1T1 KALRN PLXNA2

2.42e-041952836bdef651cf73d7381e5012d0eb3c809138fb6b92
ToppCellLA-09._Endothelium_I|World / Chamber and Cluster_Paper

SULF2 KALRN PLXNA2

2.42e-04195283fc95457a298b5d0dab687d9ee7e225a7f7b9a0d4
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

RUNX1T1 KALRN FARP1

2.42e-041952830e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SULF2 RUNX1T1 KALRN

2.46e-04196283023312af38f816a44b407e0daa32590d953caf99
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Newborn-41|World / Primary Cells by Cluster

SULF2 PLXNA2 ARPC1A

2.46e-04196283dee0984cd63a1a2fdebb4421af48ab566a5b684e
ToppCellStriatum-Neuronal-Excitatory|Striatum / BrainAtlas - Mouse McCarroll V32

RUNX1T1 KALRN ZNF180

2.46e-0419628367400193ba469cf4d939e94f5ed94995e384bc07
ToppCellbackground-Endothelial_cells|background / Sample and Cell Type and Tumor Cluster (all cells)

THSD7B RUNX1T1 KALRN

2.46e-04196283e6fb0bfab1779ec64a8c35d01519eaafbf62e977
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

RUNX1T1 KALRN MAMLD1

2.50e-04197283e8e3ba791dfaa0fab35e0329a5e34376f9ee6143
ToppCellLA-09._Endothelium_I|LA / Chamber and Cluster_Paper

SULF2 KALRN PLXNA2

2.50e-04197283ab6d1ab586a188597a39854ef980b8955ebcc645
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RUNX1T1 KALRN MAMLD1

2.50e-0419728309946ee8dfb15a2a32da06e5b331f3277ee934f4
ToppCellParenchymal-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_venous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SULF2 RUNX1T1 KALRN

2.50e-04197283b0036cf3f7e6edf8e43f16cd2f0f0e80471d2576
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

RUNX1T1 KALRN MAMLD1

2.50e-0419728385a8f1d18e0dd1d31341f5131eecd217553bf042
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SULF2 RUNX1T1 KALRN

2.50e-04197283cd509e49bbdbf991cc5913960ff3ef275ad40628
ToppCellLV-09._Endothelium_I|LV / Chamber and Cluster_Paper

SULF2 KALRN PLXNA2

2.50e-04197283f9731d4d636e51b94a96805eee6afe9aedc175e3
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

RUNX1T1 KALRN MAMLD1

2.50e-041972839b480f9c799a244bfee64487abd8a1bf07c9a3a2
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SULF2 RUNX1T1 KALRN

2.50e-04197283412cb5f37df57121ddd1492021445479c7cbccbf
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SULF2 RUNX1T1 PLXNA2

2.50e-04197283c7b33d64e5cba3a8fc6f2d6aa85ebc83893195de
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

FRAS1 FARP1 PLXNA1

2.54e-04198283b598ab958e31f1e98bd06dc0097b58ac3a3f90a3
ToppCellControl_saline-Epithelial_alveolar-AT_1-Differentiating_AT1|Control_saline / Treatment groups by lineage, cell group, cell type

FRAS1 FARP1 PLXNA1

2.54e-0419828385f424cd9bb3117c9e322031024aabb87696ce47
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

RUNX1T1 KALRN MAMLD1

2.54e-04198283a860246bcea847249a78fd2e86ed8e04371060db
ToppCellControl_saline-Epithelial_alveolar-AT_1|Control_saline / Treatment groups by lineage, cell group, cell type

FRAS1 FARP1 PLXNA1

2.54e-041982839b161285df7a4e51618f3517cfc5b8221ba55786
ToppCellBronchial-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_venous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SULF2 RUNX1T1 KALRN

2.57e-041992833a4deea6e11a0555d27497b7c9983350797aac69
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

FRAS1 FARP1 PLXNA1

2.57e-04199283d43c605a4ff221cf78d91678c15d2ad20f831c7f
ToppCellFetal_29-31_weeks|World / Lineage, Cell type, age group and donor

FRAS1 RUNX1T1 KALRN

2.57e-041992835b9d355795dd03a22f0961dfd143425c367a4654
ToppCellCOVID-19-kidney-Fibroblast-1|kidney / Disease (COVID-19 only), tissue and cell type

RUNX1T1 KALRN MAMLD1

2.57e-041992839503646ff1ad248181146ce767e9d12e882ec3bd
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

FRAS1 FARP1 PLXNA1

2.61e-04200283ddfb1f006365bf16203ee49f20200f68220cc288
ToppCellTracheal-NucSeq-Stromal-Pericyte-Muscle_pericyte_systemic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

RUNX1T1 PSAPL1 KALRN

2.61e-042002839d3ae9ea47b1017adb63aa02d10e98193d478458
ToppCellTracheal-NucSeq-Stromal-Pericyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

RUNX1T1 PSAPL1 KALRN

2.61e-0420028378cd0b7d221ef855512ee9ac9a291f61622c2e24
DrugDelsoline [509-18-2]; Down 200; 8.6uM; PC3; HT_HG-U133A

ALMS1 FARP1 PLXNA1 DDX60 MAMLD1

3.27e-061982755858_DN
Diseasecognitive function measurement

ZNF438 THSD7B RUNX1T1 ALMS1 KALRN FARP1 ZNF443

2.37e-041434277EFO_0008354
Diseasecognitive function measurement, self reported educational attainment

THSD7B RUNX1T1 ALMS1 ZNF443

2.90e-04355274EFO_0004784, EFO_0008354
Diseaseoppositional defiant disorder measurement

LIG4 RUNX1T1

4.98e-0436272EFO_0007679
Diseasealcohol consumption measurement

THSD7B RUNX1T1 ALMS1 FARP1 PLXNA2 ARPC1A

7.60e-041242276EFO_0007878
Diseasenephrotic syndrome

ZNF438 KALRN

1.93e-0371272EFO_0004255
Diseasethyroid peroxidase antibody measurement

SULF2 KALRN

1.98e-0372272EFO_0005666
Diseasephospholipids in large HDL measurement

SULF2 FADS1

2.04e-0373272EFO_0022190
Diseasefree cholesterol in large HDL measurement

SULF2 FADS1

2.38e-0379272EFO_0022157
Diseaseneuroimaging measurement

ZNF438 SULF2 FADS1 RUNX1T1 PLXNA2

2.57e-031069275EFO_0004346
Diseasecholelithiasis

ZNF438 FADS1

2.94e-0388272EFO_0004799
Diseasecortical thickness

ZNF438 SULF2 FADS1 RUNX1T1 PLXNA2

3.06e-031113275EFO_0004840
Diseaseamino acid measurement

RUNX1T1 ALMS1 FARP1 PLXNA2

3.18e-03678274EFO_0005134
Diseasealcohol use disorder measurement, alcohol consumption measurement

RUNX1T1 ARPC1A

3.56e-0397272EFO_0007878, EFO_0009458
DiseaseRS-10-hydroxywarfarin measurement

LIG4 KALRN

3.63e-0398272EFO_0803330
Diseasesmoking behavior

THSD7B RUNX1T1 PLXNA2

3.64e-03341273EFO_0004318
Diseasesmoking status measurement

ZNF438 THSD7B RUNX1T1 ALMS1 PLXNA2

3.65e-031160275EFO_0006527

Protein segments in the cluster

PeptideGeneStartEntry
WHRHLKDKLTHKEHN

C2orf16

1526

Q68DN1
WKDFFQHHPDKHREH

ALMS1

3511

Q8TCU4
RAHLFKLWHHTLQVH

DUS1L

271

Q6P1R4
KHLHDNWILHRDLKT

CDK11B

551

P21127
HRKHSHHDKHEDNKQ

FLG

101

P20930
QWVKAHELKEHNGHI

ARPC1A

41

Q92747
HHEKKIHEHGTEWAS

FRAS1

96

Q86XX4
SHQKETWILHHHIAS

MTMR6

41

Q9Y217
GSFCQHKDWEKHHHI

RUNX1T1

536

Q06455
HKDWEKHHHICGQTL

RUNX1T1

541

Q06455
VKQKEFDELVHWHSH

DDX60

491

Q8IY21
TKLWHLVKNHDHLDQ

PLXNA1

1651

Q9UIW2
ESGVKVWHLVKNHDH

PLXNA2

1646

O75051
VWHLVKNHDHGDQKE

PLXNA2

1651

O75051
TKLWHLVKNHDHADH

PLXNA3

1626

P51805
HHIIKAHAKAWHSYN

LCTL

231

Q6UWM7
DKLHSTRQHLHQMWH

KALRN

286

O60229
WRKFHDALHKNHKDV

LIG4

46

P49917
HLAAHLWKHSEALEA

FARP1

636

Q9Y4F1
KWNHLLHHFVIGHLK

FADS1

191

O60427
WHHAHQLKALAASKQ

MAMLD1

301

Q13495
ENKTVLRKHNHQWHH

SLC39A10

631

Q9ULF5
HAVKKHSWDALIKHS

FBXL21P

276

Q9UKT6
QKHVWKEMHLHAGEH

PSAPL1

506

Q6NUJ1
TVHEWKRKHHYDHQE

SWT1

296

Q5T5J6
WMVHLIDHQKLHTAH

ZSCAN1

391

Q8NBB4
HFHKHVSHAKKWHLN

ZNF180

216

Q9UJW8
LHRHKKTHWKKTHTG

ZNF443

631

Q9Y2A4
HQSYKAHHHSKSWAI

THSD7B

281

Q9C0I4
GRKEDLLHHWKHQHN

ZNF438

786

Q7Z4V0
LQAWKDHKLHIDHEI

SULF2

621

Q8IWU5