Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

CFTR TRPM2 RYR3

1.83e-0433673GO:0005217
GeneOntologyMolecularFunctionsterol ester esterase activity

CEL NCEH1

2.30e-047672GO:0004771
GeneOntologyMolecularFunctionpyrophosphatase activity

KIF18A ATF7IP CFTR TRPM2 LRRK2 RNF213 AGAP9 MTREX DDX24 DNAH8

4.59e-048396710GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

KIF18A ATF7IP CFTR TRPM2 LRRK2 RNF213 AGAP9 MTREX DDX24 DNAH8

4.64e-048406710GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

KIF18A ATF7IP CFTR TRPM2 LRRK2 RNF213 AGAP9 MTREX DDX24 DNAH8

4.64e-048406710GO:0016818
GeneOntologyMolecularFunctionATP hydrolysis activity

KIF18A ATF7IP CFTR RNF213 MTREX DDX24 DNAH8

6.78e-04441677GO:0016887
GeneOntologyMolecularFunctionATP-dependent activity

KIF18A ATF7IP CFTR RNF213 MTREX DDX24 DNAH8 DNAH14

1.01e-03614678GO:0140657
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

KIF18A ATF7IP CFTR LRRK2 RNF213 AGAP9 MTREX DDX24 DNAH8

1.09e-03775679GO:0017111
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH8 DNAH14

1.64e-0318672GO:0008569
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

TRPM2 RYR3

1.64e-0318672GO:0015278
GeneOntologyMolecularFunctionmicrotubule motor activity

KIF18A DNAH8 DNAH14

1.68e-0370673GO:0003777
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH8 DNAH14

3.96e-0328672GO:0051959
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

CFTR TRPM2 ANO1 RYR3

4.03e-03193674GO:0015276
GeneOntologyMolecularFunctionmRNA 3'-UTR AU-rich region binding

TIA1 TIAL1

4.25e-0329672GO:0035925
GeneOntologyMolecularFunctionligand-gated channel activity

CFTR TRPM2 ANO1 RYR3

4.34e-03197674GO:0022834
GeneOntologyMolecularFunctionligand-gated calcium channel activity

TRPM2 RYR3

4.84e-0331672GO:0099604
Domain-

PRPF40B PRPF40A

7.57e-0546721.10.10.440
DomainFF

PRPF40B PRPF40A

1.88e-046672PF01846
DomainFF

PRPF40B PRPF40A

1.88e-046672SM00441
DomainFF_domain

PRPF40B PRPF40A

1.88e-046672IPR002713
DomainFF

PRPF40B PRPF40A

1.88e-046672PS51676
DomainGPS

ADGRG2 ADGRE1 PKDREJ

2.44e-0434673SM00303
DomainRNA_pol_II-bd

PCF11 RPRD2

2.63e-047672IPR006903
DomainCTD_bind

PCF11 RPRD2

2.63e-047672PF04818
DomainGPS

ADGRG2 ADGRE1 PKDREJ

3.14e-0437673IPR000203
DomainRPR

PCF11 RPRD2

3.50e-048672SM00582
DomainCID

PCF11 RPRD2

3.50e-048672PS51391
DomainCID_dom

PCF11 RPRD2

3.50e-048672IPR006569
DomainP-loop_NTPase

KIF18A CFTR LRRK2 RNF213 AGAP9 MTREX DDX24 DNAH8 DNAH14 NLRP13

8.36e-048486710IPR027417
DomainDynein_heavy_chain_D4_dom

DNAH8 DNAH14

1.12e-0314672IPR024317
DomainDynein_HC_stalk

DNAH8 DNAH14

1.12e-0314672IPR024743
DomainMT

DNAH8 DNAH14

1.12e-0314672PF12777
DomainAAA_8

DNAH8 DNAH14

1.12e-0314672PF12780
DomainDHC_fam

DNAH8 DNAH14

1.29e-0315672IPR026983
DomainDynein_heavy_dom

DNAH8 DNAH14

1.29e-0315672IPR004273
DomainDynein_heavy

DNAH8 DNAH14

1.29e-0315672PF03028
Domain-

CFTR LRRK2 RNF213 AGAP9 MTREX DDX24 DNAH8 DNAH14 NLRP13

1.32e-037466793.40.50.300
DomainIGv

NECTIN1 PTGFRN DSCAML1

2.48e-0375673SM00406
DomainRRM_dom_euk

TIA1 TIAL1

3.06e-0323672IPR003954
DomainRRM_1

TIA1 TIAL1

3.06e-0323672SM00361
Domain-

PCF11 RPRD2

3.90e-03266721.25.40.90
Domainig

NECTIN1 PTGFRN DSCAML1 AMIGO1

4.83e-03190674PF00047
DomainImmunoglobulin

NECTIN1 PTGFRN DSCAML1 AMIGO1

4.83e-03190674IPR013151
DomainENTH_VHS

PCF11 RPRD2

4.84e-0329672IPR008942
DomainIg_V-set

NECTIN1 PTGFRN DSCAML1 AMIGO1

5.68e-03199674IPR013106
DomainGPCR_2_secretin-like_CS

ADGRG2 ADGRE1

6.60e-0334672IPR017983
DomainGPS

ADGRG2 ADGRE1

6.99e-0335672PF01825
DomainGPS

ADGRG2 ADGRE1

7.38e-0336672PS50221
Pubmed

Normal Calcium-Activated Anion Secretion in a Mouse Selectively Lacking TMEM16A in Intestinal Epithelium.

CFTR ANO1

3.77e-06268231263421
Pubmed

iCLIP predicts the dual splicing effects of TIA-RNA interactions.

TIA1 TIAL1

3.77e-06268221048981
Pubmed

Identification of chosen apoptotic (TIAR and TIA-1) markers expression in thyroid tissues from adolescents with immune and non-immune thyroid diseases.

TIA1 TIAL1

3.77e-06268220675271
Pubmed

TIA-1 and TIAR activate splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on their own pre-mRNAs.

TIA1 TIAL1

3.77e-06268211514562
Pubmed

Epithelial Chloride Transport by CFTR Requires TMEM16A.

CFTR ANO1

3.77e-06268228963502
Pubmed

Two isoforms of the T-cell intracellular antigen 1 (TIA-1) splicing factor display distinct splicing regulation activities. Control of TIA-1 isoform ratio by TIA-1-related protein.

TIA1 TIAL1

3.77e-06268217488725
Pubmed

The stress granule component TIA-1 binds tick-borne encephalitis virus RNA and is recruited to perinuclear sites of viral replication to inhibit viral translation.

TIA1 TIAL1

3.77e-06268224696465
Pubmed

T-cell intracellular antigen (TIA)-proteins deficiency in murine embryonic fibroblasts alters cell cycle progression and induces autophagy.

TIA1 TIAL1

3.77e-06268224086455
Pubmed

Compartmentalized crosstalk of CFTR and TMEM16A (ANO1) through EPAC1 and ADCY1.

CFTR ANO1

3.77e-06268229331508
Pubmed

Tripeptidyl peptidase II regulates sperm function by modulating intracellular Ca(2+) stores via the ryanodine receptor.

TPP2 RYR3

3.77e-06268223818952
Pubmed

Genome-wide profiling reveals a role for T-cell intracellular antigens TIA1 and TIAR in the control of translational specificity in HeLa cells.

TIA1 TIAL1

3.77e-06268224927121
Pubmed

Splicing of the large intron present in the nonstructural gene of minute virus of mice is governed by TIA-1/TIAR binding downstream of the nonconsensus donor.

TIA1 TIAL1

3.77e-06268219339348
Pubmed

Structure, tissue distribution and genomic organization of the murine RRM-type RNA binding proteins TIA-1 and TIAR.

TIA1 TIAL1

3.77e-0626828871565
Pubmed

Transmembrane protein 16A (TMEM16A) is a Ca2+-regulated Cl- secretory channel in mouse airways.

CFTR ANO1

3.77e-06268219363029
Pubmed

Identification of the sequence determinants mediating the nucleo-cytoplasmic shuttling of TIAR and TIA-1 RNA-binding proteins.

TIA1 TIAL1

3.77e-06268216278295
Pubmed

Proinflammatory cytokine secretion is suppressed by TMEM16A or CFTR channel activity in human cystic fibrosis bronchial epithelia.

CFTR ANO1

3.77e-06268222973054
Pubmed

Individual RNA recognition motifs of TIA-1 and TIAR have different RNA binding specificities.

TIA1 TIAL1

3.77e-0626828576255
Pubmed

Anoctamin 1 dysregulation alters bronchial epithelial repair in cystic fibrosis.

CFTR ANO1

3.77e-06268224080196
Pubmed

The Anion Channel TMEM16a/Ano1 Modulates CFTR Activity, but Does Not Function as an Apical Anion Channel in Colonic Epithelium from Cystic Fibrosis Patients and Healthy Individuals.

CFTR ANO1

3.77e-06268237762516
Pubmed

TIAR and TIA-1 mRNA-binding proteins co-aggregate under conditions of rapid oxygen decline and extreme hypoxia and suppress the HIF-1α pathway.

TIA1 TIAL1

3.77e-06268220980400
Pubmed

An intronic polypyrimidine-rich element downstream of the donor site modulates cystic fibrosis transmembrane conductance regulator exon 9 alternative splicing.

TIA1 CFTR

3.77e-06268214966131
Pubmed

A systematic analysis of intronic sequences downstream of 5' splice sites reveals a widespread role for U-rich motifs and TIA1/TIAL1 proteins in alternative splicing regulation.

TIA1 TIAL1

3.77e-06268218456862
Pubmed

Expression and function of Anoctamin 1/TMEM16A calcium-activated chloride channels in airways of in vivo mouse models for cystic fibrosis research.

CFTR ANO1

3.77e-06268229860639
Pubmed

TMEM16A deficiency: a potentially fatal neonatal disease resulting from impaired chloride currents.

CFTR ANO1

3.77e-06268232487539
Pubmed

Structure of the central RNA recognition motif of human TIA-1 at 1.95A resolution.

TIA1 TIAL1

3.77e-06268218201561
Pubmed

TIA-1 and TIAR interact with 5'-UTR of enterovirus 71 genome and facilitate viral replication.

TIA1 TIAL1

3.77e-06268226363455
Pubmed

TIA-1 is a translational silencer that selectively regulates the expression of TNF-alpha.

TIA1 TIAL1

3.77e-06268210921895
Pubmed

Escherichia coli alpha-hemolysin triggers shrinkage of erythrocytes via K(Ca)3.1 and TMEM16A channels with subsequent phosphatidylserine exposure.

CFTR ANO1

1.13e-05368220231275
Pubmed

Plasma membrane-localized TMEM16 proteins are indispensable for expression of CFTR.

CFTR ANO1

1.13e-05368230915480
Pubmed

TIA nuclear proteins regulate the alternate splicing of lysyl hydroxylase 2.

TIA1 TIAL1

1.13e-05368219110540
Pubmed

TIA1 prevents skipping of a critical exon associated with spinal muscular atrophy.

TIA1 TIAL1

1.13e-05368221189287
Pubmed

A WW domain binding region in methyl-CpG-binding protein MeCP2: impact on Rett syndrome.

PRPF40B PRPF40A

1.13e-05368214618241
Pubmed

Tumor protein D52 expression is post-transcriptionally regulated by T-cell intercellular antigen (TIA) 1 and TIA-related protein via mRNA stability.

TIA1 TIAL1

1.13e-05368228298474
Pubmed

Herpes simplex virus 1 induces cytoplasmic accumulation of TIA-1/TIAR and both synthesis and cytoplasmic accumulation of tristetraprolin, two cellular proteins that bind and destabilize AU-rich RNAs.

TIA1 TIAL1

1.13e-05368215280467
Pubmed

Long-term reduction of T-cell intracellular antigens leads to increased beta-actin expression.

TIA1 TIAL1

1.13e-05368224766723
Pubmed

HuR and TIA1/TIAL1 are involved in regulation of alternative splicing of SIRT1 pre-mRNA.

TIA1 TIAL1

1.13e-05368224566137
Pubmed

An essential function of the SRC-3 coactivator in suppression of cytokine mRNA translation and inflammatory response.

TIA1 TIAL1

1.13e-05368217349961
Pubmed

The RNA binding proteins TIA1 and TIAL1 promote Mcl1 mRNA translation to protect germinal center responses from apoptosis.

TIA1 TIAL1

1.13e-05368237474714
Pubmed

CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells.

CFTR ANO1

1.13e-05368224885604
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

PCF11 TIAL1 ZSCAN21 CCDC174 ATF7IP SAP30BP RPRD2 API5 DDX24 PRPF40A

1.58e-05954681036373674
Pubmed

Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility.

ADGRG2 CFTR

2.25e-05468229393851
Pubmed

The splicing regulators TIA1 and TIAL1 are required for the expression of the DNA damage repair machinery during B cell lymphopoiesis.

TIA1 TIAL1

2.25e-05468236543128
Pubmed

CFTR and TMEM16A are separate but functionally related Cl- channels.

CFTR ANO1

2.25e-05468222178883
Pubmed

Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.

ANKRD36B IRAG2 RNF213 ANKRD36 DNAH8

3.37e-0518768526460568
Pubmed

The proximal region of the 3'-untranslated region of cyclooxygenase-2 is recognized by a multimeric protein complex containing HuR, TIA-1, TIAR, and the heterogeneous nuclear ribonucleoprotein U.

TIA1 TIAL1

3.75e-05568212855701
Pubmed

A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland.

CFTR ANO1

3.75e-05568225646474
Pubmed

PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.

PCF11 TIAL1 RPRD2 MTREX TERF2 PRPF40A

5.49e-0534068624332808
Pubmed

LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins.

LRRK2 MAPK8IP3

5.62e-05668220173330
Pubmed

Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.

CFTR RFX4 ANGPTL5

6.21e-053968324709693
Pubmed

Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants.

ANKRD36B SAMHD1 HOMER1 DNAH14

8.39e-0511768412107410
Pubmed

A genome-wide association study of total serum and mite-specific IgEs in asthma patients.

SYNPO2 CDH13

1.05e-04868223967269
Pubmed

Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes.

TIA1 TIAL1

1.68e-041068212388085
Pubmed

Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.

PCF11 ATF7IP SAP30BP ANO1 API5 PRPF40A

1.86e-0442568624999758
Pubmed

Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in Japanese patients.

CFTR RYR3

2.05e-041168219096130
Pubmed

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

KIF18A CENPI RPRD2 API5 TERF2 CDH13

2.61e-0445368629656893
Pubmed

Critical roles of transcriptional coactivator MED1 in the formation and function of mouse adipose tissues.

PPARGC1A ADGRE1

2.90e-041368233888560
Pubmed

Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.

NECTIN1 PTGFRN DSCAML1 AMIGO1

2.93e-0416268425826454
Pubmed

A bead-based approach for large-scale identification of in vitro kinase substrates.

SAP30BP RPRD2 DDX24 PRPF40A

3.00e-0416368422113938
Pubmed

Essential role for the TRF2 telomere protein in adult skin homeostasis.

ADGRE1 TERF2

3.38e-041468224725274
Pubmed

An oocyte-specific ELAVL2 isoform is a translational repressor ablated from meiotically competent antral oocytes.

TIA1 TIAL1

3.38e-041468224553115
Pubmed

Human variation in alcohol response is influenced by variation in neuronal signaling genes.

TERF2 DSCAML1 CDH13 RYR3

3.60e-0417168420201926
Pubmed

Targeting SKA3 suppresses the proliferation and chemoresistance of laryngeal squamous cell carcinoma via impairing PLK1-AKT axis-mediated glycolysis.

MTREX DDX24 PRPF40A

3.87e-047268333106477
Pubmed

Pancreatitis Overview

CEL CFTR

3.89e-041568224624459
Pubmed

Rasal2 deficiency reduces adipogenesis and occurrence of obesity-related disorders.

PPARGC1A ADGRE1

3.89e-041568228580280
Pubmed

Chloride channels regulate differentiation and barrier functions of the mammalian airway.

CFTR ANO1

3.89e-041568232286221
Pubmed

Huntingtin interacts with a family of WW domain proteins.

PRPF40B PRPF40A

3.89e-04156829700202
Pubmed

A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells.

PPARGC1A SYNPO2 ZMYM3

4.03e-047368322094256
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PCF11 RNF213 UBR3 NCEH1 PTGFRN AMIGO1

4.10e-0449368615368895
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

TIAL1 SAP30BP DYSF DDX24 HOMER1 RYR3

4.28e-0449768636774506
Pubmed

Mutations in the RNA granule component TDRD7 cause cataract and glaucoma.

TIA1 TIAL1

4.44e-041668221436445
Pubmed

Deficiency of TRPM2 leads to embryonic neurogenesis defects in hyperthermia.

TRPM2 ANO1

5.65e-041868231911949
Pubmed

Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

KIF18A SYNPO2 GPBP1 ZSCAN21 SAMHD1 DDX24 KBTBD7

6.54e-0475068711230166
Pubmed

MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.

TIAL1 RPRD2 RIMS2 DDX24 DSCAML1

6.89e-0435868532460013
Pubmed

Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Is Not Required for Brown Adipogenesis but Regulates Brown Adipose Tissue Development and Function.

PPARGC1A ADGRE1

7.72e-042168227185876
Pubmed

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.

DTX3 RNF213 UBR3

8.70e-049568329643511
Pubmed

MCM9 Is Required for Mammalian DNA Mismatch Repair.

API5 MTREX

9.28e-042368226300262
Pubmed

Proteomic data on the nuclear interactome of human MCM9.

API5 MTREX

9.28e-042368226870752
Pubmed

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.

KIF18A RPRD2 TERF2 KBTBD7

9.56e-0422268437071664
Pubmed

Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

ANKRD36B RNF213 ANKRD36

1.04e-0310168310997877
Pubmed

The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.

TPP2 TIA1 TIAL1 API5 DDX24

1.08e-0339668526687479
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

KIAA1549L MTREX DDX24 PRPF40A

1.16e-0323468436243803
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

PCF11 TIA1 TIAL1 MTREX DDX24 PRPF40A ZMYM3

1.32e-0384768735850772
Pubmed

The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.

ADGRG2 ADGRE1

1.48e-032968215203201
Pubmed

EBF2 determines and maintains brown adipocyte identity.

PPARGC1A ADGRG2

1.48e-032968223499423
Pubmed

Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration.

PRPF40A ZMYM3

1.48e-032968221834987
Pubmed

Cytoplasmic aggregation of DDX1 in developing embryos: Early embryonic lethality associated with Ddx1 knockout.

TIA1 TIAL1

1.48e-032968231330130
Pubmed

Defining the lineage of thermogenic perivascular adipose tissue.

PPARGC1A ADGRE1

1.48e-032968233846639
Pubmed

SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.

TIA1 TIAL1 API5 PRPF40A

1.66e-0325868437794589
Pubmed

International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.

ADGRG2 ADGRE1

1.91e-033368225713288
Pubmed

A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.

TRPM2 PKDREJ

1.91e-033368219834762
Pubmed

Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations.

ZSCAN21 ATF7IP ZMYM3

1.92e-0312568332891193
CytobandEnsembl 112 genes in cytogenetic band chr2q11

ANKRD36B LYG2 ANKRD36 ANKRD36C

8.18e-05153684chr2q11
Cytoband2q11.2

ANKRD36B LYG2 ANKRD36

1.72e-04726832q11.2
GeneFamilyDyneins, axonemal

DNAH8 DNAH14

9.15e-0417482536
GeneFamilyImmunoglobulin like domain containing

CD244 NECTIN1 PTGFRN DSCAML1

1.70e-03193484594
GeneFamilyAnkyrin repeat domain containing

ANKRD36B ANKRD36 ANKRD36C AGAP9

3.84e-03242484403
GeneFamilyAdenosine receptors|V-set domain containing

NECTIN1 PTGFRN AMIGO1

9.25e-03163483590
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ST6GALNAC1 ANKRD36B RNF213 ANKRD36 ANKRD36C ADAM28

5.37e-071956863f8ed20ad17afe1545e574e5ca5fe33c3704c7f3
ToppCellBronchus_Control_(B.)-Epithelial-TX-Club|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

ST6GALNAC1 ANKRD36B GCNT3 ANKRD36 ANKRD36C ADAM28

6.23e-07200686292c63693eb7f435335a8cfba07aa35b72139393
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

ATF7IP RNF213 ANKRD36 ANKRD36C DDX24

6.42e-061716852e9a20f8980b78325c52065a9c14ab3656267c05
ToppCellPericytes-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

SYNPO2 KIAA1549L CEL ANO1 CDH13

6.42e-06171685bbc8d9fc83d37c9250345b1e76776610799de9ae
ToppCell3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NCEH1 SAMHD1 AGAP9 ADGRE1 PTGFRN

7.39e-0617668576fdf211bce101e83a27d822cb399487bd107027
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)-Goblet_(bronchial)_L.0.4.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ST6GALNAC1 ANKRD36B ANKRD36 ANKRD36C ADAM28

9.17e-0618468501c19a830348ab0b9c02c1546a439de70ee10f97
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ST6GALNAC1 GCNT3 CFTR ANKRD36C ADAM28

9.66e-0618668555fe25f4d0f2bc0fd4802a0a375169f2c41472fc
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LRRK2 RIMS2 DSCAML1 DNAH14 MAPK8IP3

9.91e-06187685c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

GPBP1 ATF7IP RNF213 ANKRD36 ANKRD36C

1.02e-05188685ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell367C-Epithelial_cells-Epithelial-H_(AT1)-|367C / Donor, Lineage, Cell class and subclass (all cells)

ST6GALNAC1 PPARGC1A GCNT3 CEL NECTIN1

1.02e-0518868561422c7919ca0ea02d6be4302f11b169a3ce35e5
ToppCell367C-Epithelial_cells-Epithelial-H_(AT1)|367C / Donor, Lineage, Cell class and subclass (all cells)

ST6GALNAC1 PPARGC1A GCNT3 CEL NECTIN1

1.02e-0518868518698f0b22ccbc2b93759acc1c8dbdb30a6b5a16
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ST6GALNAC1 ANKRD36B ANKRD36 ANKRD36C ADAM28

1.07e-0519068523f2ac4da431211084bb6ab0494c2e0b69547cb6
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ST6GALNAC1 ANKRD36B ANKRD36 ANKRD36C ADAM28

1.07e-051906853c337374d89e69cc0a78e65a4a7e21db7b050fcd
ToppCellPSB-critical-LOC-Epithelial-Ionocyte|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

PPARGC1A CEL ADGRG2 CFTR TRPM2

1.10e-051916858f4637e801554e2343b974fe7794f01dd2151418
ToppCellChildren_(3_yrs)-Immune-monocyte-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

CD244 TRPM2 IRAG2 SAMHD1 ADAM28

1.15e-0519368558e1930a1d80ad3729ab9604ac8ebf7308232a3d
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ANKRD36B KIAA1549L RTN3 ANKRD36 RIMS2

1.24e-05196685676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCellH1299-infected-SARSCoV2|infected / Cell line, Condition and Strain

CCDC18 ANKRD36 ANKRD36C RIMS2 PRPF40A

1.27e-051976850fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PPARGC1A KIAA1549L RTN3 RIMS2 HOMER1

1.31e-05198685c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KIAA1549L RTN3 ANKRD36 RIMS2 HOMER1

1.31e-051986856d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ANKRD36B KIAA1549L RTN3 ANKRD36 RIMS2

1.31e-051986850ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCellmedial-2-Epithelial-Mucous|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ST6GALNAC1 GCNT3 CFTR ANKRD36C ADAM28

1.34e-051996854737250b7ffa7cc19eb6b057d35d78f13b1afe66
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ATF7IP RNF213 ANKRD36 ANKRD36C DDX24

1.34e-05199685f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellmedial-Epithelial-Mucous|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ST6GALNAC1 GCNT3 CFTR ANKRD36C ADAM28

1.34e-051996854385963ab25b5378e7964b984028c25b27e5794e
ToppCelldistal-2-Epithelial-Mucous|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ST6GALNAC1 GCNT3 CFTR ANKRD36C ADAM28

1.34e-05199685c0275b5011c2bb08e873955afe2e213ec8070d0e
ToppCellCOVID-19_Moderate|World / disease group, cell group and cell class

ANKRD36B GPBP1 RNF213 ANKRD36C DDX24

1.34e-05199685952fac67588ad5676f5939e3c7f8bac803c27064
ToppCelldistal-Epithelial-Mucous-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ST6GALNAC1 GCNT3 CFTR ANKRD36C ADAM28

1.34e-051996850af89ef40807fc4ad79ab82a2186ab6e866c6931
ToppCellmedial-Epithelial-Mucous-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ST6GALNAC1 GCNT3 CFTR ANKRD36C ADAM28

1.34e-0519968553198bcf5f2f012a3ed1600d95c0923d6976a099
ToppCelldistal-Epithelial-Mucous|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ST6GALNAC1 GCNT3 CFTR ANKRD36C ADAM28

1.34e-05199685a7fe7b792d696f369ad0310a772160a1729ef223
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

ANKRD36B KIAA1549L RTN3 ANKRD36 RIMS2

1.37e-0520068548d801219bc771d6c7e151dc88ca4c179988de85
ToppCellParenchyma_COVID-19-Epithelial-TX-Club|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

ST6GALNAC1 GCNT3 CFTR ANKRD36C ADAM28

1.37e-0520068585f946dd3831acf3488c87efba96689cc2667c3a
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-Club-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ST6GALNAC1 GCNT3 CFTR ANKRD36C ADAM28

1.37e-052006858a44a4f7ea9358f2194a490e79601c98ff7fdcb0
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-Club|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

ST6GALNAC1 GCNT3 CFTR ANKRD36C ADAM28

1.37e-0520068530d428510c68da96c7c8cfd472f449ebb9631132
ToppCell3'_v3-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8|bone_marrow / Manually curated celltypes from each tissue

ATF7IP RNF213 ANKRD36 ANKRD36C

3.55e-0512168419333a660800b583fa27b495c1f7828e6636a257
ToppCellCOVID-19-kidney-Epithelial_Doublet|COVID-19 / Disease (COVID-19 only), tissue and cell type

RIMS2 RFX4 DNAH8 DSCAML1

4.70e-051306841ff28e9d3dc9a791e07d815f8fbb48f75d3f275b
ToppCell3'_v3-blood-Lymphocytic_T_CD4-T_CD4/CD8|blood / Manually curated celltypes from each tissue

RNF213 ANKRD36 ANKRD36C DDX24

5.44e-05135684ae2d3a42e567b5bade304c0caa497eb725be3565
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LYG2 LRRK2 RIMS2 DSCAML1

6.62e-051426846469cf82552b39f63e20b841c9eed50de6f58d54
ToppCellsevere_COVID-19-B_cell|severe_COVID-19 / disease group, cell group and cell class (v2)

ST6GALNAC1 MICU3 PRPF40B DNAH14

6.99e-05144684c7f696e55e2d959c58ec32640c71ef86ee25203c
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Granulocytic-Neutrophil-Neu_c3-CST7|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

KIF18A LRRK2 DYSF KBTBD7

6.99e-05144684b638398f559e7fd9d4294d1c830beeb20f905960
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

ATF7IP RNF213 ANKRD36 ANKRD36C

7.57e-0514768494998bc40f5c08295cfe3bdcbe43f13b1e564b3d
ToppCellClub_cells-SSc-ILD_02|World / lung cells shred on cell class, cell subclass, sample id

ST6GALNAC1 CFTR NECTIN1 MTREX

7.57e-051476849211242a8e40d50414d310940616eccce299a7f8
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c05-FOS|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ST6GALNAC1 PPARGC1A PCOLCE2 LCT

7.57e-05147684463af96748349c8fec2911b353a7e7e4cb072280
ToppCell3'_v3-Lung-Lymphocytic_T_CD4-T_CD4/CD8|Lung / Manually curated celltypes from each tissue

ANKRD36B ATF7IP ANKRD36 ANKRD36C

8.40e-05151684999c11d19b61d6b130ad5e623afa83cbdfe13cdd
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8|bone_marrow / Manually curated celltypes from each tissue

ATF7IP RNF213 ANKRD36 ANKRD36C

9.53e-051566841545169694f686d28648a68b552c2ae606599d66
ToppCellCOVID-19_Moderate-multiplets|World / disease group, cell group and cell class

ANKRD36B RNF213 ANKRD36 ANKRD36C

9.53e-05156684afdc025fa75e7926b1cc182c4a33654a2186abb1
ToppCelldroplet-Liver-LIVER_NPC-30m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD244 LRRK2 SAMHD1 ANKRD36

1.00e-0415868490ca742739a208d457db087655ba3d1c18a9da57
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIAA1549L CFTR DSCAML1 RYR3

1.05e-04160684c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCelldroplet-Liver-LIVER_NPC-30m-Myeloid-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD244 LRRK2 SAMHD1 ANKRD36

1.05e-041606848dae9b0cf90a09acb196223f45a14680102630b2
ToppCellTCGA-Bladder-Solid_Tissue_Normal-Urothelial_normal_tissue-Urothelial_normal_tissue|TCGA-Bladder / Sample_Type by Project: Shred V9

SYNPO2 MICU3 PCOLCE2 RYR3

1.05e-041606848a41e2c96e0e170ac35daf6c403bf961b8d7c30b
ToppCellTCGA-Bladder-Solid_Tissue_Normal|TCGA-Bladder / Sample_Type by Project: Shred V9

SYNPO2 MICU3 PCOLCE2 RYR3

1.05e-04160684d6678996e12eaf2b735f1dfae32418cb2fabf268
ToppCellTCGA-Bladder-Solid_Tissue_Normal-Urothelial_normal_tissue|TCGA-Bladder / Sample_Type by Project: Shred V9

SYNPO2 MICU3 PCOLCE2 RYR3

1.05e-04160684c8dc575562b463fd30832d322c28006f18f7ab9c
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIAA1549L CFTR DSCAML1 RYR3

1.05e-0416068425c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LRRK2 RIMS2 DSCAML1 RYR3

1.16e-041646841cb5fbd7050650047ad6f2ca792118e98d58d22b
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CFTR PCOLCE2 ANGPTL5 RYR3

1.24e-04167684a6ff7a3d9b80839c0efa91658836812e868561fa
ToppCellTCGA-Pancreas|World / Sample_Type by Project: Shred V9

GCNT3 CEL CFTR ADAM28

1.27e-04168684279d5fcf9bd3f56ab560e37eed6fb3bd57dd93de
ToppCelldroplet-Spleen-SPLEEN-1m-Myeloid-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD244 NECTIN1 TRPM2 PCOLCE2

1.30e-041696843f8aa6d2f9aa060ae1a0ea3eb47e794099fc2c2c
ToppCelldroplet-Spleen-SPLEEN-1m-Myeloid|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD244 NECTIN1 TRPM2 PCOLCE2

1.30e-0416968426de495c7562e0740689d0f78e803698e3e793db
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CFTR PCOLCE2 ANGPTL5 RYR3

1.30e-041696840c341f91dc21aaf92bead18d59684d11510502ce
ToppCellClub_cells-Donor_07|World / lung cells shred on cell class, cell subclass, sample id

ST6GALNAC1 GCNT3 KIAA1549L ANKRD36C

1.30e-0416968403b303af8a26c6ff196507fe24f5bd3d75d7b1af
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_KRT17|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SYNPO2 CFTR PCOLCE2 ANGPTL5

1.33e-0417068484d49a1f2989d98bd0acf9ec2d59f1042fc0f55b
ToppCelldroplet-Spleen-SPLEEN-1m-Myeloid-macrophage|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD244 NECTIN1 TRPM2 PCOLCE2

1.33e-04170684670027daec5a10dfa12246f1497b58db21d32a22
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SYNPO2 CFTR PCOLCE2 RYR3

1.33e-04170684417b77c12a7982b1ce4b4bc57f30335d261220f5
ToppCelldroplet-Spleen-nan-18m-Myeloid-macrophage|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD244 NECTIN1 TRPM2 RYR3

1.36e-041716844a2e6ea9674bf23e8012ef0bb2bf19ce1f55fcd5
ToppCell368C-Myeloid-Macrophage-FABP4+_Macrophage_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

DTX3 CENPI ANO1 CDH13

1.36e-04171684e59afa0a773dca3b9c208d17510ea55703b42598
ToppCelldroplet-Spleen-nan-3m-Myeloid-macrophage|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD244 NECTIN1 TRPM2 RYR3

1.36e-041716845b74df72e36ad04dfb25c72f1ca8efe043f6cda6
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SYNPO2 ANO1 RIMS2 RYR3

1.36e-0417168482de2885c8ce4fb7776da6a0207b3355c0910121
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SYNPO2 ANO1 RIMS2 RYR3

1.36e-0417168409e653973962fb884878089d281f0947f7a285f6
ToppCelldroplet-Liver-Hepatocytes-21m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRPF40B PCOLCE2 DYSF HOMER1

1.39e-04172684574ebdf36e45222bcd907cd2c2ee7ff50ed4573a
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SYNPO2 CFTR PCOLCE2 ANGPTL5

1.39e-04172684cecfe5cf20f317ea01b4604789e07a14481c4cd6
ToppCelldroplet-Spleen-nan-18m-Myeloid-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD244 NECTIN1 TRPM2 RYR3

1.39e-04172684850e4c9e9003807c19695be4b13121b0808a9389
ToppCelldroplet-Spleen-nan-18m-Myeloid|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD244 NECTIN1 TRPM2 RYR3

1.39e-04172684018d8160cfcb7882475620dc678f48a69a0f643e
ToppCelldroplet-Liver-Hepatocytes-21m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRPF40B PCOLCE2 DYSF HOMER1

1.39e-041726841627fa7035b0e0bbc82a1c0f000d8231254c680a
ToppCellBronchial_Brush-Epithelial-Ionocytes|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

CEL ADGRG2 CFTR TRPM2

1.42e-04173684e1de849dcd96063136bdac87e050ddbd55cabdcc
ToppCellBronchial_Brush-Epithelial-Ionocytes|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

CEL ADGRG2 CFTR TRPM2

1.42e-04173684f2a8f4918c1fb68d98bc3f33cd624de0f0f11e06
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CD244 CENPI CCDC18 SAMHD1

1.45e-041746847b318796728001c17b4043d2b033330c7be40c78
ToppCellBronchial_Biopsy-Epithelial-Ionocytes|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

CEL ADGRG2 CFTR TRPM2

1.45e-041746847e7b13de916cd4fa0fa6fb06e6b4942877afa9fb
ToppCellAdult-Epithelial-lung_goblet_cell-D231|Adult / Lineage, Cell type, age group and donor

ST6GALNAC1 CFTR ANO1 ADAM28

1.45e-041746847d2f802f493f19a068e097b2909a9000e2160266
ToppCellBronchial_Biopsy-Epithelial-Ionocytes|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

CEL ADGRG2 CFTR TRPM2

1.48e-0417568413b8f7dc38c90b74d4a20a84a8705d8e2ec244f6
ToppCellNS-moderate-d_0-4-Epithelial-Ionocyte|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

PPARGC1A CEL ADGRG2 CFTR

1.48e-04175684a1e0a15c69211d6db2edeb101476f0f6e08b90c8
ToppCelldroplet-Liver-Hepatocytes-21m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRPF40B PCOLCE2 ADGRE1 HOMER1

1.52e-041766848e89471f838ea81235256cc2470f1c12c9b75f8a
ToppCellControl-B_cells-B_cells|Control / group, cell type (main and fine annotations)

ATF7IP IRAG2 DNAH8 ADAM28

1.52e-04176684d2c353783bd78dc24f28e00d917b88d8294fb5df
ToppCell5'-Adult-Distal_Rectal-Epithelial-goblet-Goblet_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ST6GALNAC1 PTGFRN DSCAML1 DNAH14

1.55e-04177684e1e45956887371b1c18f1eb479dd930031497520
ToppCellnucseq-Epithelial-Epithelial_Airway-Secretory/RAS|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ST6GALNAC1 CFTR ANKRD36C ADAM28

1.55e-04177684779ba86f53650772755b52460be03f18bb204e55
ToppCellnucseq-Epithelial-Epithelial_Airway-Secretory/RAS-Secretory|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ST6GALNAC1 CFTR ANKRD36C ADAM28

1.55e-041776840f210cfb61b873c5fd77dc17eadf4d017306500e
ToppCellCOVID-19-Myeloid-MoAM4|Myeloid / Condition, Lineage and Cell class

CENPI DSCAML1 ADAM28 DNAH14

1.58e-04178684fe0017e6a1f23dc45f644b9acacc7e8aa80d0116
ToppCellBAL-Control-Myeloid-cDC-cDC-cDC_8|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PRPF40B CENPI AGAP9 ADAM28

1.62e-04179684163f5430d72ea0c1b239ea5d21e53be536636d3d
ToppCellBAL-Control-Myeloid-cDC-cDC-cDC_8|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PRPF40B CENPI AGAP9 ADAM28

1.62e-041796840624dd537a68736f4d7b8b4de2c56168ed0e60a9
ToppCellBAL-Severe-Lymphocyte-B-B_cell-B_cell-B_activate-7|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZSCAN21 PRPF40B IRAG2 ADAM28

1.65e-041806849f4bbaf6435c23e3e552ae22be8ea7884314192d
ToppCellBAL-Severe-Lymphocyte-B-B_cell-B_cell|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZSCAN21 PRPF40B IRAG2 ADAM28

1.65e-04180684b465f2f8b0e9a2034a4f1272bb00c77439164dbf
ToppCellBAL-Severe-Lymphocyte-B-B_cell|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZSCAN21 PRPF40B IRAG2 ADAM28

1.65e-04180684c3c72531af5b9f7a7416727fe609dab5180e03b6
ToppCellwk_08-11-Epithelial-Proximal_epithelial-Proximal_secretory_1|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

ST6GALNAC1 CFTR IRAG2 ADAM28

1.69e-04181684bab282cb0d9fc049f6fb094cf8b1fba104f4ea17
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LRRK2 RIMS2 DSCAML1 HOMER1

1.69e-041816849d782ba5cf5a172cb4f447763fc50e5b13ef7dd9
ToppCell10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8|Liver / Manually curated celltypes from each tissue

ANKRD36B RNF213 ANKRD36 ANKRD36C

1.69e-04181684f2315414e714ac86211546a935660c4be6e85f1b
ToppCellcellseq-Epithelial-Epithelial_Neuro-Secretory-Ionocyte|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PPARGC1A CEL CFTR TRPM2

1.72e-041826846e7dac78dc030f74e546b9f6db07556e9bb13ac2
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LRRK2 RIMS2 DSCAML1 HOMER1

1.72e-04182684eb138aa1dca9373f1586600f258df06dcf56d81f
ToppCellcellseq-Epithelial-Epithelial_Neuro-Secretory-Ionocyte-Ionocyte|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PPARGC1A CEL CFTR TRPM2

1.72e-04182684cd972d30519db706477c6b0c901165b81b74abed
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Early_airway_SMC_2|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

PPARGC1A SYNPO2 ANO1 RIMS2

1.76e-04183684a1d4f25e13f5b9e92a9ca0a804a7bed5df8fb2fe
ToppCellNS-critical-d_07-13-Epithelial-Ionocyte|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

PPARGC1A CEL ADGRG2 CFTR

1.76e-04183684ba43bca2b45be1008eebd3f033cecb061fb3a966
ToppCellTCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-5|TCGA-Liver / Sample_Type by Project: Shred V9

KIF18A GCNT3 CENPI CCDC18

1.76e-04183684f604a8b62c7088fad8365dbf8d910fc980bd3ba8
ToppCellPCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_dendritic-im_conventional_dendritic_(19)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

TRPM2 IRAG2 SAMHD1 PKDREJ

1.76e-0418368424679153b654c148dbd572e9013c0a6e58718ada
ToppCellmild_COVID-19_(asymptomatic)-T/NK_proliferative|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

KIF18A CENPI LCT RFX4

1.76e-04183684df8568751205313d149939ea2683097e3652a60b
DiseaseCongenital bilateral aplasia of vas deferens

ADGRG2 CFTR

5.08e-062672C0403814
Diseaseamyotrophic lateral sclerosis (is_marker_for)

PPARGC1A LRRK2 MTREX

3.92e-0529673DOID:332 (is_marker_for)
DiseasePancreatitis, Chronic

CEL CFTR

1.81e-049672C0149521
Diseasepulse pressure measurement

PPARGC1A KIAA1549L PRPF40B ANO1 RNF213 UBR3 PCOLCE2 ANKRD36C DYSF TERF2 CDH13

2.79e-0413926711EFO_0005763
DiseaseMoyamoya Disease

RNF213 SAMHD1

6.76e-0417672C0026654
DiseaseParkinson disease

TIAL1 TRPM2 LRRK2 RFX4 CDH13

8.22e-04321675MONDO_0005180
DiseaseParkinson Disease

PPARGC1A TRPM2 LRRK2

9.67e-0485673C0030567
Diseasetrans fatty acid measurement, trans/trans-18:2 fatty acid measurement

CDH13 RYR3

1.36e-0324672EFO_0006821, EFO_0006826

Protein segments in the cluster

PeptideGeneStartEntry
DTKQQGMTKVWVTPS

AMIGO1

291

Q86WK6
QTKPSIKSTREEKEW

AGAP9

596

Q5VTM2
PVSWTETKKQSFKQT

CFTR

676

P13569
IWTDKDKIKITPNAS

ADAM28

256

Q9UKQ2
DWSKTATNGLKKQTV

ADGRG2

906

Q8IZP9
GTWTKNNSPVKIKSV

ANGPTL5

361

Q86XS5
KSTVTLSWKPVQKVE

API5

436

Q9BZZ5
VSSQKQPAWKATSVK

ANKRD36

1191

A6QL64
QPAWKATSVKKDSVS

ANKRD36

1196

A6QL64
SSQKQPAWKATSVKK

ANKRD36B

596

Q8N2N9
PAWKATSVKKDSVSN

ANKRD36B

601

Q8N2N9
AVPDKVWKISKINNT

CDH13

626

P55290
WAQDPSQENKKKTVV

CEL

391

P19835
AWVSETGKKEVSKQT

RFX4

151

Q33E94
TVSPQKQSAWKVIFK

ANKRD36C

646

Q5JPF3
VSSQKQLAWKATSVK

ANKRD36C

1021

Q5JPF3
HPSVQEKKKSTIWQF

MAPK8IP3

561

Q9UPT6
KPTQWKSQTKENKVG

GPBP1

221

Q86WP2
KKVVVWADQTAEQPK

KIF18A

611

Q8NI77
PNNKNSTEWEKVKSL

LMBRD1

166

Q9NUN5
KKSAWSSAQVKVTDT

NCEH1

71

Q6PIU2
SLKTKPVRNNNTVKW

CSNKA2IP

706

A0A1B0GTH6
PQTQGKTWIKSKEKE

DNAH8

3471

Q96JB1
VPSKAKVVWEKFSSQ

LCT

876

P09848
AKQNSPVVEVWDKKT

LRRK2

2366

Q5S007
QHPKKWTADTVSSKV

KIAA1549L

621

Q6ZVL6
AVTTDEPKVAKTWKS

MICU3

171

Q86XE3
PEESTNKWKQRVKTA

ANO1

481

Q5XXA6
ITSTTPQWKKNRVTV

KBTBD7

571

Q8WVZ9
NSKCTWKITVPEGKV

PCOLCE2

56

Q9UKZ9
KKNWVPTSKHAVTVS

HOMER1

21

Q86YM7
SQPAKKTYTWNTKEE

PRPF40A

381

O75400
AIVKTENSWSNKAKS

PPARGC1A

181

Q9UBK2
PKENVENWQSSKSAK

PCF11

581

O94913
TKTVKKTLEPKWNQT

RIMS2

861

Q9UQ26
KNKVTVSKPVWDFLS

DTX3

16

Q8N9I9
AKWKISADSQKSSVQ

CCDC18

1236

Q5T9S5
QSIQVTWKAPKKELQ

DSCAML1

1001

Q8TD84
KNPKSQQLIEWVKDT

GCNT3

311

O95395
FVTVWKQSIPSTSQK

DNAH14

3291

Q0VDD8
SATVPSQWKKIGEVK

ATF7IP

1206

Q6VMQ6
IKAIQKKFPTWSVAQ

LYG2

156

Q86SG7
SQSTAAKVPKKAKTW

DDX24

166

Q9GZR7
SEKKNNPSKWDVSSV

IRAG2

461

Q12912
TTNKKPSIWSKQNVG

CCDC174

46

Q6PII3
TLSAWKVKQDPSNSK

CENPI

26

Q92674
QWKKSQTSTNPKAAL

RPRD2

166

Q5VT52
PNSIQTKVDSIAWKK

CD244

41

Q9BZW8
QKTVVVKNTLNPTWD

DYSF

1186

O75923
NSWVKSKDVFSKPVN

PTGFRN

526

Q9P2B2
TWDLVPQVKQQTDKS

RTN3

341

O95197
ITPQKKEWNDSTSVQ

SAMHD1

591

Q9Y3Z3
KLTQKPSEFTWDAQK

PKDREJ

761

Q9NTG1
TEAQSWKSQDTKTTQ

ST6GALNAC1

151

Q9NSC7
VPVLKQISTWTKFTK

ADGRE1

381

Q14246
EPCSKASWTVQESKK

RNF213

76

Q63HN8
QKPVWEKISSSGTAK

ZSCAN21

141

Q9Y5A6
AKKSGVTIQVWKPSV

SYNPO2

1076

Q9UMS6
WGVVVNFSKKSNVKP

MTREX

671

P42285
SSRTQWEKPQVKESK

RYR3

4051

Q15413
QESLSSWIPENIKKK

TRPM2

56

O94759
ATVRTWEVENPKKQK

WDR70

306

Q9NW82
KNWVQTLRPVSAKTK

TPP2

791

P29144
KQSVWEKPSVLKSKA

PRPF40B

116

Q6NWY9
QKRKSKWDSAIPVTT

SAP30BP

251

Q9UHR5
EANQVVRPKTSSKWS

UBR3

1056

Q6ZT12
KEVKVNWATTPSSQK

TIAL1

76

Q01085
DSTTNITKKQKWTVE

TERF2

481

Q15554
VKVNWATTPSSQKKD

TIA1

76

P31483
KSKGSQTEEWKPQVI

ZMYM3

851

Q14202
KVQKLTCKSVTPEWV

NLRP13

756

Q86W25
KITQVTWQKSTNGSK

NECTIN1

61

Q15223