Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

GLUD1 GLUD2

8.29e-062582GO:0016639
GeneOntologyMolecularFunctionglutamate dehydrogenase [NAD(P)+] activity

GLUD1 GLUD2

8.29e-062582GO:0004353
GeneOntologyMolecularFunctionglutamate dehydrogenase (NAD+) activity

GLUD1 GLUD2

8.29e-062582GO:0004352
GeneOntologyMolecularFunctionglutamate dehydrogenase (NADP+) activity

GLUD1 GLUD2

8.29e-062582GO:0004354
GeneOntologyMolecularFunctionhistone H2AK119 ubiquitin ligase activity

PCGF3 PCGF5

4.96e-054582GO:0140862
GeneOntologyMolecularFunctionhistone H2A ubiquitin ligase activity

PCGF3 PCGF5

1.23e-046582GO:0141053
GeneOntologyMolecularFunctionL-leucine binding

GLUD1 GLUD2

1.73e-047582GO:0070728
GeneOntologyMolecularFunctionADP binding

GLUD1 GLUD2 MYO18A

3.67e-0448583GO:0043531
GeneOntologyMolecularFunctionhistone ubiquitin ligase activity

PCGF3 PCGF5

5.37e-0412582GO:0140852
GeneOntologyMolecularFunctioncarboxylic acid binding

P4HA2 ACACB NRTN GLUD1 GLUD2

6.44e-04239585GO:0031406
GeneOntologyMolecularFunctionorganic acid binding

P4HA2 ACACB NRTN GLUD1 GLUD2

8.47e-04254585GO:0043177
GeneOntologyMolecularFunctionprotein domain specific binding

WBP11 CRIM1 CASKIN1 DLG3 CARD11 RELA RIMS2 MYB ITPR1

8.83e-04875589GO:0019904
GeneOntologyMolecularFunctionphosphate ion binding

SH2B3 RELA

9.69e-0416582GO:0042301
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-NH2 group of donors

GLUD1 GLUD2

1.52e-0320582GO:0016638
GeneOntologyMolecularFunctionNAD+ binding

GLUD1 GLUD2

1.52e-0320582GO:0070403
GeneOntologyBiologicalProcesstricarboxylic acid metabolic process

ACACB GLUD1 GLUD2

1.59e-0518573GO:0072350
GeneOntologyBiologicalProcessdosage compensation by inactivation of X chromosome

PCGF3 YTHDC1 PCGF5

2.97e-0522573GO:0009048
GeneOntologyBiologicalProcesssex-chromosome dosage compensation

PCGF3 YTHDC1 PCGF5

3.89e-0524573GO:0007549
GeneOntologyBiologicalProcessglutamate biosynthetic process

GLUD1 GLUD2

7.46e-055572GO:0006537
GeneOntologyBiologicalProcessresponse to aluminum ion

GLUD1 GLUD2

1.12e-046572GO:0010044
GeneOntologyBiologicalProcesschromatin organization

SATB1 SUPT6H SMARCA1 BAZ1B RELA PCGF3 YTHDC1 INO80D PCGF5 JMJD1C

1.53e-048965710GO:0006325
GeneOntologyBiologicalProcesschromatin remodeling

SATB1 SUPT6H SMARCA1 BAZ1B PCGF3 YTHDC1 INO80D PCGF5 JMJD1C

1.82e-04741579GO:0006338
GeneOntologyBiologicalProcessglutamate catabolic process

GLUD1 GLUD2

2.08e-048572GO:0006538
GeneOntologyCellularComponentnuclear protein-containing complex

CDK13 SUPT6H POLR1C SMARCA1 CPSF1 BAZ1B RELA ASCC3 PCGF3 INO80D PCGF5 JMJD1C MYB

8.05e-0513775813GO:0140513
DomainELFV_dehydrog_N

GLUD1 GLUD2

8.83e-062562PF02812
DomainGlu/Leu/Phe/Val_DH_C

GLUD1 GLUD2

8.83e-062562IPR006096
DomainGlu/Leu/Phe/Val_DH_dimer_dom

GLUD1 GLUD2

8.83e-062562IPR006097
DomainGlu/Leu/Phe/Val_DH

GLUD1 GLUD2

8.83e-062562IPR006095
DomainELFV_dehydrog

GLUD1 GLUD2

8.83e-062562PF00208
DomainELFV_dehydrog

GLUD1 GLUD2

8.83e-062562SM00839
DomainGlu/Leu/Phe/Val_DH_AS

GLUD1 GLUD2

8.83e-062562IPR033524
DomainNAD_bind_Glu_DH

GLUD1 GLUD2

8.83e-062562IPR033922
DomainGLFV_DEHYDROGENASE

GLUD1 GLUD2

8.83e-062562PS00074
DomainRAWUL

PCGF3 PCGF5

1.84e-047562IPR032443
DomainRAWUL

PCGF3 PCGF5

1.84e-047562PF16207
DomainPDZ

MYO18A DLG3 CARD11 RIMS2

1.01e-03148564SM00228
Domain-

MYO18A DLG3 CARD11 RIMS2

1.06e-031505642.30.42.10
DomainPDZ

MYO18A DLG3 CARD11 RIMS2

1.09e-03151564PS50106
DomainPDZ

MYO18A DLG3 CARD11 RIMS2

1.11e-03152564IPR001478
DomainGUANYLATE_KINASE_2

DLG3 CARD11

2.15e-0323562PS50052
DomainGUANYLATE_KINASE_1

DLG3 CARD11

2.15e-0323562PS00856
DomainZnf_RING/FYVE/PHD

RNF181 BAZ1B PCGF3 RIMS2 PCGF5 WDR59

2.45e-03459566IPR013083
DomainCadherin_cytoplasmic-dom

DSC1 CDH15

2.53e-0325562IPR000233
DomainCadherin_C

DSC1 CDH15

2.53e-0325562PF01049
DomainCatenin_binding_dom

DSC1 CDH15

3.40e-0329562IPR027397
Domain-

DSC1 CDH15

3.40e-03295624.10.900.10
Domain-

MYO18A SMARCA1 DLG3 CARD11 ASCC3 REM2 DNAH7

6.67e-037465673.40.50.300
DomainPDZ

MYO18A DLG3 RIMS2

8.72e-03141563PF00595
PathwayKEGG_MEDICUS_REFERENCE_BLOCKING_UBIQUITINATION_OF_H2AK119_BY_CK2

AUTS2 PCGF3 PCGF5

6.12e-0612443M47943
PathwayKEGG_MEDICUS_REFERENCE_TRANSCRIPTIONAL_ACTIVATION_BY_ACETYLATION_OF_H3K27

AUTS2 PCGF3 PCGF5

1.26e-0515443M47973
PathwayWP_TCELL_RECEPTOR_SIGNALING

SH2B3 CARD11 RELA ITPR1

1.73e-0490444M39725
Pubmed

Human transcription factor protein interaction networks.

WBP11 IRS4 SATB1 ACACB USP9X GLI3 GLUD1 MYO18A SMARCA1 AUTS2 CPSF1 BAZ1B RELA PCGF3 INO80D PCGF5 JMJD1C MYB

9.45e-121429581835140242
Pubmed

Genomic organization and chromosomal localization of the mouse synexin gene.

GLUD1 GLUD2 MYB

4.39e-0855838053909
Pubmed

Interaction network of human early embryonic transcription factors.

SATB1 ACACB GLUD1 SMARCA1 AUTS2 BAZ1B PCGF3 PCGF5

1.23e-0735158838297188
Pubmed

Isolation and genetic mapping of two novel members of the murine Wnt gene family, Wnt11 and Wnt12, and the mapping of Wnt5a and Wnt7a.

GLUD1 GLUD2 ITPR1

9.58e-07125837896292
Pubmed

Transcriptome analysis of mouse stem cells and early embryos.

MAGEB1 HECTD4 DLG3 PRAMEF11 MYB ITPR1 NGDN

2.42e-0636358714691545
Pubmed

TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.

WBP11 IRS4 USP9X ZC3H13 GLUD1 AUTS2 CPSF1 RELA YTHDC1 NGDN

2.69e-06922581027609421
Pubmed

ANKRD49 inhibits etoposide-induced intrinsic apoptosis of GC-1 cells by modulating NF-κB signaling.

ANKRD49 RELA

2.73e-06258230798416
Pubmed

Critical role of the cysteine 323 residue in the catalytic activity of human glutamate dehydrogenase isozymes.

GLUD1 GLUD2

2.73e-06258215750346
Pubmed

Molecular cloning, structure and expression analysis of a full-length mouse brain glutamate dehydrogenase cDNA.

GLUD1 GLUD2

2.73e-0625821711373
Pubmed

Glutamate Delta-1 Receptor Regulates Inhibitory Neurotransmission in the Nucleus Accumbens Core and Anxiety-Like Behaviors.

GLUD1 GLUD2

2.73e-06258234173171
Pubmed

Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation.

GLUD1 GLUD2

2.73e-06258228621566
Pubmed

GluD1 knockout mice with a pure C57BL/6N background show impaired fear memory, social interaction, and enhanced depressive-like behavior.

GLUD1 GLUD2

2.73e-06258232078638
Pubmed

Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate.

GLUD1 GLUD2

2.73e-06258220529287
Pubmed

Development of mice with brain-specific deletion of floxed glud1 (glutamate dehydrogenase 1) using cre recombinase driven by the nestin promoter.

GLUD1 GLUD2

2.73e-06258223595828
Pubmed

Determination of glutamate dehydrogenase activity and its kinetics in mouse tissues using metabolic mapping (quantitative enzyme histochemistry).

GLUD1 GLUD2

2.73e-06258225124006
Pubmed

Unexpected histone H3 tail-clipping activity of glutamate dehydrogenase.

GLUD1 GLUD2

2.73e-06258223673664
Pubmed

Interaction between glutamate dehydrogenase (GDH) and L-leucine catabolic enzymes: intersecting metabolic pathways.

GLUD1 GLUD2

2.73e-06258221621574
Pubmed

Lack of evidence for direct ligand-gated ion channel activity of GluD receptors.

GLUD1 GLUD2

2.73e-06258239052831
Pubmed

Metabolism changes during aging in the hippocampus and striatum of glud1 (glutamate dehydrogenase 1) transgenic mice.

GLUD1 GLUD2

2.73e-06258224442550
Pubmed

Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia.

GLUD1 GLUD2

2.73e-06258228911206
Pubmed

The Amplifying Pathway of the β-Cell Contributes to Diet-induced Obesity.

GLUD1 GLUD2

2.73e-06258227137930
Pubmed

GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution.

GLUD1 GLUD2

2.73e-06258226440896
Pubmed

Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase.

GLUD1 GLUD2

2.73e-06258222875990
Pubmed

Study of structure-function relationships in human glutamate dehydrogenases reveals novel molecular mechanisms for the regulation of the nerve tissue-specific (GLUD2) isoenzyme.

GLUD1 GLUD2

2.73e-06258212742085
Pubmed

Molecular basis of human glutamate dehydrogenase regulation under changing energy demands.

GLUD1 GLUD2

2.73e-06258215578726
Pubmed

Important role of Ser443 in different thermal stability of human glutamate dehydrogenase isozymes.

GLUD1 GLUD2

2.73e-06258215044002
Pubmed

Induction of excitatory and inhibitory presynaptic differentiation by GluD1.

GLUD1 GLUD2

2.73e-06258222138648
Pubmed

Glutamate Dehydrogenase Is Important for Ammonia Fixation and Amino Acid Homeostasis in Brain During Hyperammonemia.

GLUD1 GLUD2

2.73e-06258234220417
Pubmed

Expression of human GLUD1 and GLUD2 glutamate dehydrogenases in steroid producing tissues.

GLUD1 GLUD2

2.73e-06258226241911
Pubmed

Differential levels of glutamate dehydrogenase 1 (GLUD1) in Balb/c and C57BL/6 mice and the effects of overexpression of the Glud1 gene on glutamate release in striatum.

GLUD1 GLUD2

2.73e-06258221446915
Pubmed

Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydrogenase driven by positive Darwinian selection.

GLUD1 GLUD2

2.73e-06258218688271
Pubmed

The complex regulation of human glud1 and glud2 glutamate dehydrogenases and its implications in nerve tissue biology.

GLUD1 GLUD2

2.73e-06258222658952
Pubmed

GluD1 binds GABA and controls inhibitory plasticity.

GLUD1 GLUD2

2.73e-06258238060673
Pubmed

Gene expression patterns in the hippocampus during the development and aging of Glud1 (Glutamate Dehydrogenase 1) transgenic and wild type mice.

GLUD1 GLUD2

2.73e-06258224593767
Pubmed

Increases in anterograde axoplasmic transport in neurons of the hyper-glutamatergic, glutamate dehydrogenase 1 (Glud1) transgenic mouse: Effects of glutamate receptors on transport.

GLUD1 GLUD2

2.73e-06258238124277
Pubmed

Potentiation of neuronal activity by tonic GluD1 current in brain slices.

GLUD1 GLUD2

2.73e-06258237154294
Pubmed

Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis.

GLUD1 GLUD2

2.73e-06258219015267
Pubmed

Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission.

GLUD1 GLUD2

2.73e-06258222924626
Pubmed

Human GLUD1 and GLUD2 glutamate dehydrogenase localize to mitochondria and endoplasmic reticulum.

GLUD1 GLUD2

2.73e-06258219448744
Pubmed

Nerve tissue-specific (GLUD2) and housekeeping (GLUD1) human glutamate dehydrogenases are regulated by distinct allosteric mechanisms: implications for biologic function.

GLUD1 GLUD2

2.73e-06258211032875
Pubmed

Polycomb group RING finger proteins 3/5 activate transcription via an interaction with the pluripotency factor Tex10 in embryonic stem cells.

PCGF3 PCGF5

2.73e-06258229054931
Pubmed

Single amino acid substitution (G456A) in the vicinity of the GTP binding domain of human housekeeping glutamate dehydrogenase markedly attenuates GTP inhibition and abolishes the cooperative behavior of the enzyme.

GLUD1 GLUD2

2.73e-06258211950837
Pubmed

Localization of Human Glutamate Dehydrogenases Provides Insights into Their Metabolic Role and Their Involvement in Disease Processes.

GLUD1 GLUD2

2.73e-06258229943084
Pubmed

Glutamate dehydrogenase deficiency disrupts glutamate homeostasis in hippocampus and prefrontal cortex and impairs recognition memory.

GLUD1 GLUD2

2.73e-06258231898404
Pubmed

Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux.

GLUD1 GLUD2

2.73e-06258215378063
Pubmed

Widening Spectrum of Cellular and Subcellular Expression of Human GLUD1 and GLUD2 Glutamate Dehydrogenases Suggests Novel Functions.

GLUD1 GLUD2

2.73e-06258227422263
Pubmed

NRF1 association with AUTS2-Polycomb mediates specific gene activation in the brain.

AUTS2 PCGF3 PCGF5

2.94e-061758334637754
Pubmed

Polymorphisms revealed by PCR with single, short-sized, arbitrary primers are reliable markers for mouse and rat gene mapping.

GLUD1 GLUD2 MYB

2.94e-06175831617216
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

WBP11 IRS4 ACACB CDK13 GLUD1 GLUD2 MYO18A SMARCA1 DLG3 SPAG17 RIMS2 NGDN

3.75e-061442581235575683
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

DSC1 SUPT6H VPS13C GLUD2 MYO18A CPSF1 BAZ1B RIMS2 ITPR1

4.16e-0675458935906200
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

DSC1 ZC3H13 GLUD1 POLR1C MYO18A SMARCA1 CPSF1 BAZ1B ASCC3 YTHDC1 NGDN

6.30e-061257581136526897
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

WBP11 DSC1 SUPT6H ZC3H13 SMARCA1 BAZ1B ASCC3 NGDN

7.14e-0660558828977666
Pubmed

Postsynaptic δ1 glutamate receptor assembles and maintains hippocampal synapses via Cbln2 and neurexin.

GLUD1 GLUD2

8.19e-06358229784783
Pubmed

The structure of apo human glutamate dehydrogenase details subunit communication and allostery.

GLUD1 GLUD2

8.19e-06358212054821
Pubmed

Trans-Synaptic Signaling through the Glutamate Receptor Delta-1 Mediates Inhibitory Synapse Formation in Cortical Pyramidal Neurons.

GLUD1 GLUD2

8.19e-06358231704028
Pubmed

Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 Is Governed by an Activated Glutamate Dehydrogenase.

GLUD1 GLUD2

8.19e-06358229229616
Pubmed

Liver Glutamate Dehydrogenase Controls Whole-Body Energy Partitioning Through Amino Acid-Derived Gluconeogenesis and Ammonia Homeostasis.

GLUD1 GLUD2

8.19e-06358230002133
Pubmed

Glutamate delta-1 receptor regulates cocaine-induced plasticity in the nucleus accumbens.

GLUD1 GLUD2

8.19e-06358230315226
Pubmed

Regulation of NF-kappaB activation in T cells via association of the adapter proteins ADAP and CARMA1.

CARD11 RELA

8.19e-06358217478723
Pubmed

Isolation of a human brain cDNA for glutamate dehydrogenase.

GLUD1 GLUD2

8.19e-0635823585334
Pubmed

GOT1 regulates CD8+ effector and memory T cell generation.

GLUD1 GLUD2

8.19e-06358236640309
Pubmed

Screening for new inhibitors of the human Mitochondrial Pyruvate Carrier and their effects on hepatic glucose production and diabetes.

GLUD1 GLUD2

8.19e-06358237871770
Pubmed

Human T-cell lymphotropic virus type 1 Tax represses c-Myb-dependent transcription through activation of the NF-kappaB pathway and modulation of coactivator usage.

RELA MYB

8.19e-06358211585920
Pubmed

Deletion of glutamate delta-1 receptor in mouse leads to enhanced working memory and deficit in fear conditioning.

GLUD1 GLUD2

8.19e-06358223560106
Pubmed

Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase.

GLUD1 GLUD2

8.19e-06358220670938
Pubmed

Identification of disulfide bond formation between MitoNEET and glutamate dehydrogenase 1.

GLUD1 GLUD2

8.19e-06358224295216
Pubmed

New gene functions in megakaryopoiesis and platelet formation.

SATB1 SH2B3 JMJD1C MYB

1.05e-058158422139419
Pubmed

Enriched expression of GluD1 in higher brain regions and its involvement in parallel fiber-interneuron synapse formation in the cerebellum.

GLUD1 GLUD2

1.64e-05458224872547
Pubmed

Essential role of GluD1 in dendritic spine development and GluN2B to GluN2A NMDAR subunit switch in the cortex and hippocampus reveals ability of GluN2B inhibition in correcting hyperconnectivity.

GLUD1 GLUD2

1.64e-05458225721396
Pubmed

The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.

GLUD1 GLUD2

1.64e-05458223663782
Pubmed

Members of the nuclear factor kappa B family transactivate the murine c-myb gene.

RELA MYB

1.64e-0545827706314
Pubmed

GLUD1 determines murine muscle stem cell fate by controlling mitochondrial glutamate levels.

GLUD1 GLUD2

1.64e-05458239121856
Pubmed

A restriction fragment length polymorphism at murine Glud locus co-segregates with Rib-1, Es-10, and Tcra on chromosome 14.

GLUD1 GLUD2

1.64e-0545822566156
Pubmed

A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects.

SH2B3 JMJD1C MYB

2.54e-053458324026423
Pubmed

TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.

DSC1 CDK13 MYO18A CPSF1 YTHDC1 NEXN USP6NL ITPR1 NGDN

2.59e-0594958936574265
Pubmed

Chromosomal mapping of glutamate dehydrogenase gene sequences to mouse chromosomes 7 and 14.

GLUD1 GLUD2

2.72e-0555822045113
Pubmed

Proximity of the CTLA-1 serine esterase and Tcr alpha loci in mouse and man.

GLUD1 GLUD2

2.72e-0555823182016
Pubmed

Chromosomal assignment of 11 loci in the rat by mouse-rat somatic hybrids and linkage.

GLUD1 GLUD2

2.72e-0555827873882
Pubmed

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.

GLUD1 GLUD2

2.72e-05558216959573
Pubmed

Combined analysis of exon splicing and genome wide polymorphism data predict schizophrenia risk loci.

ZC3H13 DLG3

2.72e-05558224507884
Pubmed

Macrophage-derived glutamine boosts satellite cells and muscle regeneration.

GLUD1 GLUD2

2.72e-05558233116312
Pubmed

Regulation of T cell function by the ubiquitin-specific protease USP9X via modulating the Carma1-Bcl10-Malt1 complex.

USP9X CARD11

2.72e-05558223690623
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SUPT6H VPS13C CASKIN1 HECTD4 AUTS2 RIMS2 USP6NL

2.78e-0552958714621295
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

WBP11 SUPT6H ZC3H13 GLUD1 POLR1C MYO18A BAZ1B ASCC3 HSPA12B USP6NL ITPR1

3.01e-051487581133957083
Pubmed

SR protein kinases promote splicing of nonconsensus introns.

CDK13 ZC3H13 CARD11 YTHDC1 JMJD1C NGDN

3.08e-0536158626167880
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

CDK13 SUPT6H POLR1C BAZ1B DLG3 RELA ASCC3 YTHDC1 INO80D USP6NL NGDN

3.20e-051497581131527615
Pubmed

An AUTS2-Polycomb complex activates gene expression in the CNS.

AUTS2 PCGF3 PCGF5

3.56e-053858325519132
Pubmed

Proteomic and yeast 2-hybrid screens to identify PTEN binding partners.

USP9X GLUD1 GLUD2 MYO18A ASCC3

3.84e-0522658537839992
Pubmed

The human glutamate dehydrogenase gene family: gene organization and structural characterization.

GLUD1 GLUD2

4.08e-0565828486350
Pubmed

hnRNPK Recruits PCGF3/5-PRC1 to the Xist RNA B-Repeat to Establish Polycomb-Mediated Chromosomal Silencing.

PCGF3 PCGF5

4.08e-05658229220657
Pubmed

Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression.

PCGF3 PCGF5

4.08e-05658231029541
Pubmed

WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci.

SMARCA1 BAZ1B

4.08e-05658211980720
Pubmed

PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes.

AUTS2 PCGF3 PCGF5

4.49e-054158322325352
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

CDK13 SUPT6H ZC3H13 POLR1C CPSF1 BAZ1B YTHDC1 INO80D JMJD1C NGDN

5.04e-051294581030804502
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

WBP11 CDK13 SUPT6H ZC3H13 MYO18A ASCC3 YTHDC1 NGDN

5.58e-0580758822681889
Pubmed

Essential Role for Polycomb Group Protein Pcgf6 in Embryonic Stem Cell Maintenance and a Noncanonical Polycomb Repressive Complex 1 (PRC1) Integrity.

PCGF3 PCGF5

5.71e-05758228049731
Pubmed

Identification of quantitative trait loci for haloperidol-induced catalepsy on mouse chromosome 14.

GLUD1 GLUD2

5.71e-05758210454512
Pubmed

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis.

GLUD1 GLUD2

5.71e-05758219498109
Pubmed

PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation.

PCGF3 PCGF5

5.71e-05758228596365
Pubmed

SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.

SUPT6H ZC3H13 SMARCA1 CPSF1 BAZ1B

6.31e-0525158531076518
GeneFamilyRing finger proteins|Polycomb group ring fingers

PCGF3 PCGF5

9.95e-05740261
GeneFamilyPDZ domain containing

MYO18A DLG3 CARD11 RIMS2

3.47e-041524041220
GeneFamilyCalcium voltage-gated channel subunits|Membrane associated guanylate kinases

DLG3 CARD11

1.50e-0326402904
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

SMARCA1 MYB

6.12e-0353402532
GeneFamilyX-linked mental retardation|Angiotensin receptors

USP9X DLG3

6.12e-0353402103
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

WBP11 DLG3 ITPR1

7.43e-03181403694
GeneFamilySterile alpha motif domain containing

CASKIN1 SAMD3

1.62e-0288402760
GeneFamilyAnkyrin repeat domain containing

CASKIN1 ANKRD49 ANKRD55

1.63e-02242403403
GeneFamilySH2 domain containing

SH2B3 SUPT6H

2.10e-02101402741
GeneFamilyRing finger proteins

RNF181 PCGF3 PCGF5

2.27e-0227540358
CoexpressionBUSSLINGER_GASTRIC_IMMUNE_CELLS

SH2B3 CDK13 USP9X VPS13C HECTD4 ANKRD49 AUTS2 BAZ1B CARD11 SAMD3 ASCC3 YTHDC1 INO80D PCGF5 JMJD1C ITPR1

9.21e-0814925816M40023
CoexpressionGSE32255_WT_UNSTIM_VS_JMJD2D_KNOCKDOWN_4H_LPS_STIM_DC_UP

CRIM1 SH2B3 PCGF5 USP6NL ITPR1

4.31e-05175585M8908
CoexpressionHADDAD_B_LYMPHOCYTE_PROGENITOR

P4HA2 CRIM1 CDK13 AUTS2 JMJD1C ITPR1

4.35e-05290586M939
CoexpressionGSE2770_TGFB_AND_IL4_ACT_VS_ACT_CD4_TCELL_6H_DN

WBP11 USP9X RNF181 RELA PCGF3

7.56e-05197585M6107
CoexpressionGSE5542_UNTREATED_VS_IFNG_TREATED_EPITHELIAL_CELLS_24H_UP

CRIM1 SH2B3 SPC25 AUTS2 DLG3

7.74e-05198585M6522
CoexpressionGSE39820_CTRL_VS_TGFBETA1_IL6_IL23A_CD4_TCELL_UP

CRIM1 USP9X PCGF5 JMJD1C ITPR1

7.93e-05199585M5607
CoexpressionGSE16385_IFNG_TNF_VS_UNSTIM_MACROPHAGE_ROSIGLITAZONE_TREATED_DN

CDK13 ANKRD49 AUTS2 WDR59 NGDN

8.12e-05200585M8032
CoexpressionGSE34006_A2AR_KO_VS_A2AR_AGONIST_TREATED_TREG_DN

CRIM1 USP9X RNF181 YTHDC1 MYB

8.12e-05200585M9049
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

MGAT5 CRIM1 CDK13 USP9X SPC25 SMARCA1 BAZ1B ASCC3 ITPR1

1.03e-04856589M4500
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-lymphocytic-B_lymphocytic-B_cell|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MGAT5 CDK13 VPS13C JMJD1C USP6NL ITPR1

2.00e-07194586ff661419b697aef51a53fdeac8d37d870d65f491
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

USP9X VPS13C INO80D JMJD1C ITPR1

4.62e-06188585ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MGAT5 AUTS2 JMJD1C USP6NL ITPR1

4.75e-06189585b13f315f617840eb5143a4e8a33a657c20365c21
ToppCell10x3'2.3-week_17-19-Lymphocytic_B-B_lineage-pro_B_progenitor|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

P4HA2 CDK13 AUTS2 MYB ITPR1

4.99e-0619158540813c397f533c2f4a6359a77757f736b6d9e07d
ToppCellBrain_organoid-organoid_Tanaka_cellReport-6m-Neuronal-Intermediate|6m / Sample Type, Dataset, Time_group, and Cell type.

WBP11 ZC3H13 YTHDC1 JMJD1C CDH15

6.25e-062005857c261e39ac30b318511373ab7302aa53b8b81b9c
ToppCellMild/Remission-B_naive-4|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

MGAT5 SATB1 SPAG17 ITPR1

4.15e-05148584dd5e1bc02824e743e1c030a303e32f27a359a8ca
ToppCellSevere-B_naive-1|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

MGAT5 SATB1 PRAG1 ITPR1

5.49e-051595842881b054bbeb479221ee3c38bbd9b0815b123579
ToppCellfacs-Lung-ENDOMUCIN-18m-Lymphocytic-Natural_Killer|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MGAT5 CARD11 SAMD3 PRAG1

5.91e-051625840321fc954ae4ad67ca438cbbc84632562d222188
ToppCellfacs-Lung-ENDOMUCIN-18m-Lymphocytic-NK_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MGAT5 CARD11 SAMD3 PRAG1

5.91e-051625845731f9514434296132df4bc86f78ce87b07cdeca
ToppCellMild/Remission-B_naive-4|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

MGAT5 SATB1 SPAG17 ITPR1

6.96e-05169584c3a6179a64589a370108fea809b157839347759c
ToppCellCOVID-19-B_cells-Activated_B_cells|COVID-19 / group, cell type (main and fine annotations)

MGAT5 CARD11 USP6NL ITPR1

8.32e-05177584653bb62a3744d4024ab3186ee01d410ed62832a6
ToppCellnucseq-Immune-Lymphocytic_B-Lymphocytic_B-B|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MGAT5 CARD11 USP6NL ITPR1

9.07e-051815848d8cc4dae2c8bd5f4b1c159f2a52edc4c9449c86
ToppCellIPF-Lymphoid-B|IPF / Disease state, Lineage and Cell class

MGAT5 AUTS2 CARD11 ITPR1

9.47e-05183584e37d2c015c34471a8a54a0299e94b0371e1ada5a
ToppCelldroplet-Marrow-nan-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VPS13C BAZ1B ASCC3 JMJD1C

9.67e-051845841154a5ad7b8512272b7476f949ddac350910bfb7
ToppCellhuman_hepatoblastoma-Hepatic_Stellate_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

OLFML2B GLI3 NEXN ITPR1

1.01e-04186584cb1fc4b9140666b43415e21c9b434dc9b144e9d0
ToppCellE16.5-samps-Mesenchymal-Myofibroblast|E16.5-samps / Age Group, Lineage, Cell class and subclass

SUPT6H OLFML2B PRAG1 NEXN

1.01e-04186584e044b3428b7eacfdc72d0f57cdabaa1de04c74cd
ToppCelldroplet-Tongue-nan-24m-Epithelial-parabasal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DSC1 PDZK1IP1 MYO18A USP6NL

1.01e-0418658418c06041c6c8a0ebac17b3c8aaebd67e652d315a
ToppCelldroplet-Lung-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l39|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NRTN OLFML2B AUTS2 NEXN

1.03e-04187584218c9b4f28499389c43005d9626af2ac01066027
ToppCellhuman_hepatoblastoma-Tumor_cells-T2|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

ACACB ZC3H13 GLUD1 WDR59

1.03e-04187584f3e37c18ac6471c7992609bbddfa4975571c815c
ToppCelldroplet-Lung-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NRTN OLFML2B AUTS2 NEXN

1.03e-04187584c7ac4b328efc2ebb72f71154661914193ff402ca
ToppCellrenal_medulla_nuclei-Adult_normal_reference|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

MGAT5 ACACB AUTS2 JMJD1C

1.09e-04190584f1363f7806cfc4f14fbc1b0e8dac2de813a88eee
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD4_rest-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ZC3H13 SAMD3 ASCC3 WDR59

1.09e-0419058469c5c4d5f4fb6e5ae2c9dbf9d209faf093c3f769
ToppCellfacs-Pancreas-Endocrine-3m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP9X SMARCA1 RIMS2 ITPR1

1.12e-04191584b3de0393d6510543533cd851e47a0f95739a0e4e
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP9X SMARCA1 RIMS2 ITPR1

1.12e-04191584657297cd19d05a7e7bb74fc3a086fbd95f47aae4
ToppCelldroplet-Fat-Gat-18m-Endothelial|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACACB CRIM1 HSPA12B PRAG1

1.14e-04192584c312e39003c51503c9f648332fb5c6218f33f99b
ToppCelldroplet-Fat-Gat-18m-Endothelial-Cd36+|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACACB CRIM1 HSPA12B PRAG1

1.14e-04192584df09056f0e562f53b6fb30b674d2d83e9eb857d0
ToppCellRA-09._Endothelium_I|RA / Chamber and Cluster_Paper

CRIM1 SPC25 HSPA12B PRAG1

1.14e-041925848a1b1c3e83a68ad74f8f4eb00455c9e41aa57cfc
ToppCelldroplet-Fat-Gat-18m-Endothelial-endothelial_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACACB CRIM1 HSPA12B PRAG1

1.14e-04192584133b3ad251d72ff31e45e1dc6217945516ac63de
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

SH2B3 POLR1C PCGF3 ITPR1

1.16e-0419358408696a99309f5b088692ddac8cca35413b5e810d
ToppCellControl-CD8+_T_naive|Control / Disease condition and Cell class

DSC1 SATB1 PRAG1 MYB

1.16e-04193584627d345baf1940218c61907305705298e473dbab
ToppCellfacs-Thymus-nan-3m-Lymphocytic-DN_to_DP_transition_(most_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SATB1 VPS13C HECTD4 MYB

1.16e-04193584a6a864644e1b80b7417ea0a27281e79068a3fd3d
ToppCellfacs-Diaphragm-Limb_Muscle-3m-Mesenchymal|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OLFML2B RELA JMJD1C CDH15

1.21e-041955844d63e0dca30ae57960459d2fbcba09122273e37b
ToppCell10x5'v1-week_14-16-Lymphocytic_B-B_lineage-pro_B_progenitor|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

P4HA2 CDK13 JMJD1C ITPR1

1.21e-04195584dc84a910b6f6eb9994cd683aa4fd813a82198e5f
ToppCellfacs-Diaphragm-Limb_Muscle-3m-Mesenchymal-nan|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OLFML2B RELA JMJD1C CDH15

1.21e-04195584661af601a3561fe3aacf2444ad7b8927fa88b48a
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SATB1 USP9X VPS13C ASCC3

1.21e-041955843e519cffa6144a62b06124642a14c9ff39b76554
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SATB1 USP9X VPS13C ASCC3

1.21e-041955847796ea9247f4c63762f0de8490fed08b9717fa23
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Mesenchymal|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VPS13C ASCC3 NEXN JMJD1C

1.21e-041955845c86fddd6d0530beecf45ea5ba6b823123847696
ToppCellbackground-Endothelial_cells|background / Sample and Cell Type and Tumor Cluster (all cells)

CRIM1 AUTS2 PRAG1 ANKRD55

1.23e-04196584e6fb0bfab1779ec64a8c35d01519eaafbf62e977
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OLFML2B USP9X GLUD1 JMJD1C

1.23e-04196584151f1a29a91f8b234e9b6ed062666357a2f69128
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-skeletal_muscle_satellite_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OLFML2B USP9X RELA CDH15

1.26e-041975845bc11aff92da2a0aca8473f997fe7a99f3cae75d
ToppCell10x3'2.3-week_14-16-Mesenchymal_osteo-stroma-osteochondral_precursor|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

OLFML2B GLI3 SMARCA1 CDH15

1.26e-04197584c165c6fd12dc649b39e920d8528e2eb65c61956b
ToppCellH1299-infected-SARSCoV2|infected / Cell line, Condition and Strain

ZC3H13 YTHDC1 RIMS2 NEXN

1.26e-041975840fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCellControl-Control-Lymphocyte-T/NK-NK_activated|Control / Disease, condition lineage and cell class

MGAT5 SUPT6H DLG3 CARD11

1.28e-0419858476d5fe4e5bbe6c73a6ca409b80b5c3924e07cab7
ToppCell(03)_KRT6B+-(2)_GFP_FOXI1|(03)_KRT6B+ / shred by cell type by condition

CRIM1 VPS13C ZC3H13 INO80D

1.31e-04199584c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCellcontrol-unassigned|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SATB1 ACACB SMARCA1 ANKRD55

1.31e-0419958450e2da35edff1aadef939cfbd4549f73c1a07717
ToppCellcontrol-unassigned|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SATB1 ACACB SMARCA1 ANKRD55

1.31e-041995845db7c8089172ac8e796613b3cef618d87007a0ab
ToppCellMacroglial-Astrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

ACACB GLI3 GLUD1 DNAH7

1.33e-04200584941536b7c32f1e63c70535233b2ccce0cd7bf96e
ToppCellMacroglial-Astrocytes-SLC14A1---|Macroglial / cells hierarchy compared to all cells using T-Statistic

ACACB GLI3 GLUD1 DNAH7

1.33e-04200584d6fcbf4f4bc1b89a9929d7b114c6b907b6979900
ToppCellMacroglial-Astrocytes-SLC14A1----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

ACACB GLI3 GLUD1 DNAH7

1.33e-04200584f861509b54185d89931db64da1b9d81986cc7938
ToppCellSepsis-Int-URO-Lymphocyte-T/NK-dn_T|Int-URO / Disease, condition lineage and cell class

CPSF1 SAMD3 USP6NL MYB

1.33e-04200584020439d9e70fff7246650ab0e9105236688c3ec3
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

CDK13 VPS13C YTHDC1 JMJD1C

1.33e-0420058412f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellMacroglial-Astrocytes-SLC14A1|Macroglial / cells hierarchy compared to all cells using T-Statistic

ACACB GLI3 GLUD1 DNAH7

1.33e-0420058416f468217427921fa18c6d078ffa990eb019b257
ToppCellInfluenza-Influenza_Severe-Lymphocyte-T/NK-CD4+_T_naive|Influenza_Severe / Disease, condition lineage and cell class

DSC1 NRTN ANKRD55 MYB

1.33e-042005840382f8fc27d18003761725e714beb6b3f3150057
ToppCellMacroglial-Astrocytes-SLC14A1--|Macroglial / cells hierarchy compared to all cells using T-Statistic

ACACB GLI3 GLUD1 DNAH7

1.33e-042005840442894c39eec69850c090957a5dc7bcecd21e04
ToppCellMacroglial-Astrocytes-SLC14A1-|Macroglial / cells hierarchy compared to all cells using T-Statistic

ACACB GLI3 GLUD1 DNAH7

1.33e-0420058401819446deeab9054f5cfe889d53bb49d137dbc0
ToppCellsevere-CD4+_T_naive|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SATB1 ANKRD55 PCGF5 MYB

1.33e-04200584f74bdabadca8ad6dae1b6e6812c66325aac50db0
Drugphenyltriethoxysilane

GLUD1 GLUD2

6.38e-062582CID000013075
Drugmethylmercuric bromide

GLUD1 GLUD2

6.38e-062582CID000068175
Drug5-methylisophthalate

GLUD1 GLUD2

6.38e-062582CID000068137
DrugG-3SH

GLUD1 GLUD2

6.38e-062582CID000174237
Drugx 1 s

GLUD1 GLUD2

6.38e-062582CID000409694
Drugiodoacetyldiethylstilbestrol

GLUD1 GLUD2

6.38e-062582CID006455327
DrugRicinine [524-40-3]; Down 200; 24.4uM; HL60; HT_HG-U133A

CDK13 RELA PCGF3 ANKRD55 INO80D NGDN

9.63e-061935862505_DN
Drugphenanthridinone; Up 200; 51.2uM; MCF7; HT_HG-U133A_EA

SUPT6H VPS13C BAZ1B DLG3 RELA PCGF3

9.63e-061935861115_UP
DrugAG-013608 [351320-38-2]; Up 200; 10uM; MCF7; HT_HG-U133A

DSC1 SATB1 SMARCA1 AUTS2 ITPR1 NGDN

1.05e-051965866435_UP
DrugEthambutol dihydrochloride [1070-11-7]; Up 200; 14.4uM; MCF7; HT_HG-U133A

IRS4 ACACB CDK13 OLFML2B RIMS2 MYB

1.08e-051975864120_UP
Drug5-amino-1-phenyltetrazole

GLUD1 GLUD2 MYB

1.73e-0520583CID000021640
Drugmethoxyethylmercury

GLUD1 GLUD2

1.91e-053582CID000115155
Drug4-methylumbelliferyl laurate

GLUD1 GLUD2

1.91e-053582CID000600674
Drugmethylmercuric iodide

GLUD1 GLUD2

1.91e-053582CID000067347
Druglenthionine

GLUD1 GLUD2

1.91e-053582CID000067521
Drugmildiomycin

GLUD1 GLUD2

1.91e-053582CID000125665
Drugmethyl benzoquate

GLUD1 GLUD2

3.81e-054582CID000026383
Drug8-BDB-TADP

GLUD1 GLUD2

3.81e-054582CID000130791
Drugcadina-3,9-diene

GLUD1 GLUD2

3.81e-054582CID000010657
DrugAC1L9CUQ

GLUD1 GLUD2

3.81e-054582CID000442451
Drugpentenoic acid

GLUD1 GLUD2

3.81e-054582CID000012299
Drugalpha-ketoglutaramate

GLUD1 GLUD2

3.81e-054582CID000000048
Drugluxabendazole

GLUD1 GLUD2

3.81e-054582CID000072019
Drugureidoglycine

GLUD1 GLUD2

3.81e-054582CID000439649
DrugN-butylmaleimide

GLUD1 GLUD2

3.81e-054582CID000239780
DrugIvin

GLUD1 GLUD2

3.81e-054582CID000014083
Drugalpha-methylglutamate

GLUD1 GLUD2

3.81e-054582CID000095440
Drug2b E2

GLUD1 GLUD2

3.81e-054582CID005327076
Drugisophthalate

GLI3 GLUD1 GLUD2

3.91e-0526583CID000008496
Drug1-pheg

GLUD1 GLUD2

6.35e-055582CID000152041
Drug5'-FSBAzA

GLUD1 GLUD2

6.35e-055582CID000130430
Drugadenine N1-oxide

GLUD1 GLUD2

6.35e-055582CID000093557
Drugbathocuproine

GLUD1 GLUD2

6.35e-055582CID000065149
Drugcholine sulfate

GLUD1 GLUD2

6.35e-055582CID000000485
Drugl-413

GLUD1 GLUD2

6.35e-055582CID000012475
DrugAC1NRA4I

GLUD1 GLUD2

6.35e-055582CID005287695
Drugisosteviol lactone

GLUD1 GLUD2

6.35e-055582CID000401559
Drug3-aminopicolinate

GLUD1 GLUD2

6.35e-055582CID000073836
Drugthioridazine hydrochloride; Up 200; 10uM; MCF7; HT_HG-U133A

ACACB OLFML2B RIMS2 MYB ITPR1

9.29e-051795855590_UP
Drugalpha-monofluoromethylputrescine

GLUD1 GLUD2

9.50e-056582CID000134201
DrugdadAB

GLUD1 GLUD2

9.50e-056582CID000022626
DrugN-methylhydantoin

GLUD1 GLUD2

9.50e-056582CID000069217
Drugdiazonium-1-H-tetrazole

GLUD1 GLUD2

9.50e-056582CID000188312
DrugAC1L448Y

GLUD1 GLUD2

9.50e-056582CID000200389
Drug2-BDB-TAMP

GLUD1 GLUD2

9.50e-056582CID000127220
DrugEmid

GLUD1 GLUD2

9.50e-056582CID000074798
Drugdimethylmalonate

GLUD1 GLUD2

9.50e-056582CID000007943
DrugAC1L8SA5

GLUD1 GLUD2

9.50e-056582CID000407285
Drug2-methyl-1,2,3,4-tetrahydroisoquinoline

GLUD1 GLUD2

9.50e-056582CID000015362
Druglanosol

GLUD1 GLUD2

9.50e-056582CID000078659
Drugisodiazinon

GLUD1 GLUD2

9.50e-056582CID000133913
DrugBetulinic acid [472-15-1]; Up 200; 8.8uM; MCF7; HT_HG-U133A

SH2B3 BAZ1B RELA WDR59 ITPR1

1.17e-041885853281_UP
Drugcarbophenothion

GLUD1 GLUD2

1.33e-047582CID000013081
Drug37474A

GLUD1 GLUD2

1.33e-047582CID004330138
DrugAC1L1B5W

GLUD1 GLUD2

1.33e-047582CID000001296
Drug2-oxoglutaconic acid

GLUD1 GLUD2

1.33e-047582CID006443759
Drugd-serine methyl ester hydrochloride

GLUD1 GLUD2

1.33e-047582CID000090387
DrugPHA-00745360 [351320-33-7]; Down 200; 1uM; MCF7; HT_HG-U133A

CDK13 CPSF1 RIMS2 ITPR1 NGDN

1.36e-041945853910_DN
Drugsemustine; Down 200; 100uM; PC3; HT_HG-U133A

ACACB GLI3 DLG3 MYB ITPR1

1.36e-041945857545_DN
DrugTiapride hydrochloride [51012-33-0]; Up 200; 11uM; MCF7; HT_HG-U133A

CDK13 VPS13C ZC3H13 ITPR1 NGDN

1.39e-041955854686_UP
DrugPropidium iodide [25535-16-4]; Up 200; 6uM; MCF7; HT_HG-U133A

CPSF1 DNAH7 CDH15 ITPR1 NGDN

1.39e-041955856104_UP
Drugdiclofenac sodium; Up 200; 10uM; PC3; HG-U133A

ACACB ZC3H13 CPSF1 RIMS2 CDH15

1.39e-04195585445_UP
DrugOxymetazoline hydrochloride [2315-02-8]; Down 200; 13.4uM; MCF7; HT_HG-U133A

BAZ1B DLG3 RIMS2 WDR59 NGDN

1.39e-041955852278_DN
DrugEsculin Hydrate [531-75-9]; Down 200; 11.8uM; MCF7; HT_HG-U133A

CRIM1 CDK13 SUPT6H PCGF3 INO80D

1.42e-041965855411_DN
DrugNialamide [51-12-7]; Up 200; 13.4uM; MCF7; HT_HG-U133A

MGAT5 ACACB OLFML2B ZC3H13 ITPR1

1.42e-041965854347_UP
DrugAH6809; Up 200; 1uM; PC3; HT_HG-U133A

NRTN OLFML2B BAZ1B PCGF3 INO80D

1.46e-041975857049_UP
DrugConessine [546-06-5]; Up 200; 11.2uM; MCF7; HT_HG-U133A

CDK13 SMARCA1 WDR59 ITPR1 NGDN

1.46e-041975852792_UP
Drug2-Aminobenzenesulfonamide [3306-62-5]; Up 200; 23.2uM; MCF7; HT_HG-U133A

SATB1 WDR59 USP6NL MYB ITPR1

1.49e-041985855422_UP
DrugNaringin hydrate [11032-30-7]; Up 200; 6.6uM; MCF7; HT_HG-U133A

ACACB SUPT6H RIMS2 ITPR1 NGDN

1.49e-041985853286_UP
DrugOndansetron Hydrochloride [103639-04-9]; Up 200; 12.2uM; MCF7; HT_HG-U133A

BAZ1B DNAH7 INO80D WDR59 NGDN

1.49e-041985856270_UP
DrugNizatidine [76963-41-2]; Up 200; 12uM; MCF7; HT_HG-U133A

SMARCA1 AUTS2 WDR59 MYB ITPR1

1.49e-041985855406_UP
DrugRacecadotril [81110-73-8]; Down 200; 10.4uM; MCF7; HT_HG-U133A

GLI3 BAZ1B RELA PCGF3 WDR59

1.49e-041985852774_DN
DrugXylazine [7361-61-7]; Up 200; 18.2uM; MCF7; HT_HG-U133A

IRS4 ACACB CDK13 OLFML2B DNAH7

1.49e-041985854147_UP
DrugSulfachloropyridazine [80-32-0]; Up 200; 14uM; MCF7; HT_HG-U133A

DSC1 SATB1 SMARCA1 DNAH7 NGDN

1.53e-041995853944_UP
DrugBemegride [64-65-3]; Up 200; 25.8uM; MCF7; HT_HG-U133A

DSC1 ACACB NRTN USP6NL ITPR1

1.53e-041995853389_UP
DrugCephalosporanic acid, 7-amino [957-68-6]; Up 200; 14.6uM; MCF7; HT_HG-U133A

CDK13 ZC3H13 BAZ1B RIMS2 ITPR1

1.53e-041995854826_UP
DrugCefalonium [5575-21-3]; Up 200; 8.8uM; HL60; HT_HG-U133A

IRS4 MGAT5 ACACB DLG3 RIMS2

1.53e-041995852921_UP
Drug6-chloroquinoxaline-2,3-diol

GLUD1 GLUD2

1.77e-048582CID000081143
Drug2-heptanol

GLUD1 GLUD2

1.77e-048582CID000010976
Drug2'(3')-O-(2,4,6-trinitrophenyl)-ADP

GLUD1 GLUD2

1.77e-048582CID000644359
DrugNessler's reagent

GLUD1 GLUD2

1.77e-048582CID000024542
Drugiminoglutarate

GLUD1 GLUD2

1.77e-048582CID000152649
Drugbidisomide

GLUD1 GLUD2

1.77e-048582CID000059798
DrugPheg

GLUD1 GLUD2

1.77e-048582CID003080746
DrugAC1MQ2IK

GLUD1 GLUD2

1.77e-048582CID003394958
DrugAC1N690Y

GLUD1 GLUD2

1.77e-048582CID004256264
Drugtrimethyllead chloride

GLUD1 GLUD2

1.77e-048582CID000223969
DrugNHS-ASA

GLUD1 GLUD2

2.27e-049582CID003035647
Drugdimethyl L-glutamate

GLUD1 GLUD2

2.27e-049582CID000093032
DrugAC1L1GWH

GLUD1 GLUD2

2.27e-049582CID000003872
DrugAC1N4HBY

GLUD1 GLUD2

2.27e-049582CID004128835
DrugDCQX

GLUD1 GLUD2

2.27e-049582CID000001845
Drugadipamide

GLUD1 GLUD2

2.27e-049582CID000012364
Drugtemelastine

GLUD1 GLUD2

2.27e-049582CID000055482
DrugAsparagusate

GLUD1 GLUD2

2.27e-049582CID000016682
Drugsilver nitrate

GLUD1 GLUD2 SPAG17

2.66e-0449583CID000024470
Drugbis-NAD

GLUD1 GLUD2

2.83e-0410582CID003081557
DrugNmiQ

GLUD1 GLUD2

2.83e-0410582CID000019850
DrugS884

GLUD1 GLUD2

2.83e-0410582CID004685067
Drugdiglycerol

GLUD1 GLUD2

2.83e-0410582CID000042953
Diseasefascioliasis (biomarker_via_orthology)

GLUD1 GLUD2

1.06e-053562DOID:885 (biomarker_via_orthology)
Diseasechildhood absence epilepsy (biomarker_via_orthology)

GLUD1 GLUD2

5.28e-056562DOID:1825 (biomarker_via_orthology)
Diseaseneutrophil count, eosinophil count

SH2B3 SPC25 HECTD4 PCGF3 JMJD1C

5.30e-05213565EFO_0004833, EFO_0004842
Diseaseneutrophil count, basophil count

SH2B3 SPC25 HECTD4 PCGF3 JMJD1C

6.72e-05224565EFO_0004833, EFO_0005090
Diseasevascular cell adhesion protein 1 measurement

MGAT5 SH2B3

7.38e-057562EFO_0020846
Diseasealkaline phosphatase measurement

MGAT5 ACACB NRTN GLI3 CASKIN1 BAZ1B PRAG1 JMJD1C ITPR1

1.15e-041015569EFO_0004533
Diseasegranulocyte count

SH2B3 SPC25 HECTD4 PCGF3 JMJD1C

1.21e-04254565EFO_0007987
Diseasemultiple sclerosis

MGAT5 SH2B3 CARD11 ANKRD55 CDH15 MYB ITPR1

1.28e-04594567MONDO_0005301
DiseaseIschemic stroke, fibrinogen measurement

SH2B3 HECTD4 JMJD1C

1.58e-0455563EFO_0004623, HP_0002140
Diseasefibrinogen measurement, factor VII measurement

SH2B3 HECTD4 JMJD1C

1.86e-0458563EFO_0004619, EFO_0004623
Diseaseforced expiratory volume, body mass index

SH2B3 HECTD4

1.92e-0411562EFO_0004314, EFO_0004340
Diseasetotal blood protein measurement

CRIM1 SH2B3 SPC25 ASCC3 HSPA12B ANKRD55

2.05e-04449566EFO_0004536
Diseasevenous thromboembolism, fibrinogen measurement

SH2B3 HECTD4 JMJD1C

2.85e-0467563EFO_0004286, EFO_0004623
DiseaseC-X-C motif chemokine 11 measurement

SH2B3 JMJD1C

3.17e-0414562EFO_0008057
Diseasehepatic encephalopathy (biomarker_via_orthology)

GLUD1 GLUD2

3.66e-0415562DOID:13413 (biomarker_via_orthology)
DiseaseIschemic stroke, tissue plasminogen activator measurement

SH2B3 HECTD4

3.66e-0415562EFO_0004791, HP_0002140
Diseaselymphocyte count

P4HA2 SH2B3 CDK13 SPC25 HECTD4 AUTS2 CARD11 JMJD1C MYB ITPR1

3.87e-0414645610EFO_0004587
Diseasemitochondrial DNA measurement

NRTN SPC25 PCGF3 JMJD1C MYB

3.95e-04328565EFO_0006312
DiseaseIschemic stroke, plasminogen activator inhibitor 1 measurement

SH2B3 HECTD4

4.17e-0416562EFO_0004792, HP_0002140
Diseasemyopia (is_implicated_in)

P4HA2 CPSF1

4.17e-0416562DOID:11830 (is_implicated_in)
Diseasefactor XI measurement, Ischemic stroke

SH2B3 HECTD4

4.72e-0417562EFO_0004694, HP_0002140
Diseasemetabolic syndrome

SPC25 HECTD4 BAZ1B JMJD1C

5.71e-04200564EFO_0000195
Diseasefactor VIII measurement, Ischemic stroke

SH2B3 HECTD4

5.93e-0419562EFO_0004630, HP_0002140
Diseaseplatelet-to-lymphocyte ratio

SH2B3 SPC25 AUTS2 JMJD1C MYB

6.26e-04363565EFO_0008446
Diseaseneuroticism measurement, cognitive function measurement

SH2B3 AUTS2 ASCC3 PCGF3 PCGF5 JMJD1C

6.99e-04566566EFO_0007660, EFO_0008354
Diseasetransferrin glycosylation measurement

MGAT5 NRTN

7.26e-0421562EFO_0021537
DiseaseN-glycan measurement

MGAT5 NRTN

7.98e-0422562EFO_0004999
Diseasemean arterial pressure, alcohol drinking

SH2B3 GLI3 HECTD4

8.67e-0498563EFO_0004329, EFO_0006340
Diseasemyeloproliferative disorder

SH2B3 MYB

1.03e-0325562EFO_0004251
Diseasefibrinogen measurement

SH2B3 JMJD1C ITPR1

1.18e-03109563EFO_0004623
DiseaseIschemic stroke, factor VII measurement

SH2B3 HECTD4

1.39e-0329562EFO_0004619, HP_0002140
DiseaseDrugs used in diabetes use measurement

SPC25 AUTS2 DNAH7 JMJD1C

1.41e-03255564EFO_0009924
Diseasefatty acid measurement

MGAT5 ACACB BAZ1B PRAG1 JMJD1C

1.42e-03436565EFO_0005110
Diseasediastolic blood pressure, unipolar depression

SH2B3 HECTD4

1.49e-0330562EFO_0003761, EFO_0006336
DiseaseIschemic stroke, von Willebrand factor measurement

SH2B3 HECTD4

1.49e-0330562EFO_0004629, HP_0002140
Diseaseaspartate aminotransferase measurement

P4HA2 MGAT5 SH2B3 SPC25 HECTD4 PRAG1 ITPR1

1.55e-03904567EFO_0004736
Diseaseserum IgA measurement

SH2B3 ANKRD55

1.59e-0331562EFO_0004912
Diseasetemporal lobe epilepsy (biomarker_via_orthology)

GLUD1 GLUD2

1.59e-0331562DOID:3328 (biomarker_via_orthology)
Diseasefatty liver disease (implicated_via_orthology)

ACACB RELA

1.59e-0331562DOID:9452 (implicated_via_orthology)
Diseaseinflammatory bowel disease

P4HA2 SH2B3 ZC3H13 RELA ANKRD55

1.61e-03449565EFO_0003767
Diseaseserum gamma-glutamyl transferase measurement

RNF181 HECTD4 BAZ1B HSPA12B JMJD1C USP6NL ITPR1

1.65e-03914567EFO_0004532
DiseaseMental Retardation, X-Linked 1

USP9X DLG3

1.69e-0332562C2931498
Diseasecoffee consumption

HECTD4 BAZ1B

1.69e-0332562EFO_0004330
Diseaseeosinophil count

MGAT5 SH2B3 SPC25 HECTD4 CARD11 RELA DNAH7 WDR59 MYB

1.83e-031488569EFO_0004842

Protein segments in the cluster

PeptideGeneStartEntry
PHTQEAFRTREEYEA

BAZ1B

26

Q9UIG0
HQKDPSRDRYREEDT

ANKRD55

361

Q3KP44
TEEDLDYRTENQHVP

CDK13

1271

Q14004
KPEEDNDYHRSDEQV

PCGF3

141

Q3KNV8
AENFHEEDDVDVRPA

NEXN

486

Q0ZGT2
FQEDHYPDSDKRREI

NOBOX

291

O60393
RPTAYEDEVSFLDAH

NRTN

166

Q99748
DEFAEDRIYRHLEPA

ACACB

1481

O00763
HSLNRYAASDSEPER

CASKIN1

881

Q8WXD9
NEDDKDYHRSDPQIA

PCGF5

126

Q86SE9
NEDESPGQTYHRERR

GLI3

41

P10071
PSHYEEALRDEEERA

MAGEB1

301

P43366
PYEEADHNSLAEIRT

MGAT5

206

Q09328
TTFRREADPDDHYQP

ITPR1

1936

Q14643
SHRDSRNPDLAVYVE

JMJD1C

46

Q15652
ERDERYIHPQQEAFS

CPSF1

1061

Q10570
DDEHDPLDNTSRPRY

MYO18A

2021

Q92614
RSSEHENAYENVPEE

PDZK1IP1

91

Q13113
EADRSFRDREPHDYS

AUTS2

1111

Q8WXX7
AAAAIQRHYNDEDPE

MYB

276

P10242
VNTRDEDEYTPLHRA

ANKRD49

101

Q8WVL7
RFGSDEDDHYRLNDE

HECTD4

391

Q9Y4D8
TARDYYHDLDPEEAR

HSPA12B

121

Q96MM6
QYEPHFDFSRNDERD

P4HA2

426

O15460
DRRSQHEPQFYEDSD

RIMS2

306

Q9UQ26
DRDCEAADRQPYHRS

RIMS2

1076

Q9UQ26
RHYSEAVADREDDPN

GLUD1

51

P00367
CDFHDPKREDTNYRE

DNAH7

2271

Q8WXX0
QVDYRDNRLHPSEDS

CRIM1

921

Q9NZV1
RPRRDNEVDGQDYHF

DLG3

661

Q92796
KIEDDNDNAPYFEHR

DSC1

231

Q08554
TLRYQRHASDDDDAE

INO80D

351

Q53TQ3
EEDQDAYDISQLRHP

CDH15

661

P55291
RYKEDAPHRSTVEED

CARD11

576

Q9BXL7
RHYSELVADREDDPN

GLUD2

51

P49448
PHRARAFDEDEDDPY

IRS4

686

O14654
ARDHEDYDPQTVRLG

USP9X

631

Q93008
AGDYRHRRTEQEEDE

SMARCA1

141

P28370
PTDDDTYEEHRRDKA

RNF181

121

Q9P0P0
YRDEESSSPARHGEQ

SAMD3

91

Q8N6K7
HADPRLFEYRNQGDE

POLR1C

116

O15160
DLPEDRYDKAQATAH

TEX45

256

Q8NA69
RDAAAAYAHPEYEER

OLFML2B

231

Q68BL8
PERDAIYEQESNAVH

SATB1

561

Q01826
RGEDDHTNRYIDDEP

SPAG17

201

Q6Q759
HTNRYIDDEPDDGAQ

SPAG17

206

Q6Q759
LNEARDYEVSDSAPH

SPC25

176

Q9HBM1
DAEEYTDLPVRHNED

ASCC3

1851

Q8N3C0
RDSYQRHETEQFPAE

SUPT6H

551

Q7KZ85
EEALERAYSQSPRHA

USP6NL

566

Q92738
EQYSDAPEEIRDARH

NGDN

211

Q8NEJ9
PDHGDRSFYDLEADQ

PRAMEF11

461

O60813
HLEHEPVNRARDSDY

SH2B3

541

Q9UQQ2
HEDGIIRPYDRQESE

VPS13C

3601

Q709C8
SAHEPENPEDTYERR

REM2

141

Q8IYK8
DSAASHQAEPEAYER

PRAG1

1106

Q86YV5
DVGRRRPEDYDIHNS

YTHDC1

531

Q96MU7
LTYSDPRERERDQHD

WDR59

831

Q6PJI9
YSPELAQRGHDDDVS

WBP11

236

Q9Y2W2
FQYLPDTDDRHRIEE

RELA

286

Q04206
RREHSPDSDAYNSGD

ZC3H13

841

Q5T200