Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA stem-loop binding	ERVK-6 ZC3H12A ERVK-7 ERVK-10 ERVK-8 ERVK-11	7.81e-10	21	102	6	GO:0035613
GeneOntologyMolecularFunction	RNA-DNA hybrid ribonuclease activity	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11	1.42e-09	11	102	5	GO:0004523
GeneOntologyMolecularFunction	RNA-directed DNA polymerase activity	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11	6.08e-09	14	102	5	GO:0003964
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-18 ERVK-25	3.13e-08	37	102	6	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-18 ERVK-25	3.70e-08	38	102	6	GO:0070001
GeneOntologyMolecularFunction	RNA endonuclease activity, producing 5'-phosphomonoesters	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11	1.21e-06	37	102	5	GO:0016891
GeneOntologyMolecularFunction	DNA polymerase activity	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11	1.38e-06	38	102	5	GO:0034061
GeneOntologyMolecularFunction	intracellularly calcium-gated channel activity	ANO4 ANO1 ANO5 ANO3	2.92e-06	20	102	4	GO:0141147
GeneOntologyMolecularFunction	intracellularly calcium-gated chloride channel activity	ANO4 ANO1 ANO5 ANO3	2.92e-06	20	102	4	GO:0005229
GeneOntologyMolecularFunction	RNA endonuclease activity	ERVK-6 ZC3H12A ERVK-7 ERVK-10 ERVK-8 ERVK-11	3.15e-06	79	102	6	GO:0004521
GeneOntologyMolecularFunction	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11	3.66e-06	46	102	5	GO:0016893
GeneOntologyMolecularFunction	phospholipid scramblase activity	ANO4 ANO1 ANO5 ANO3	5.27e-06	23	102	4	GO:0017128
GeneOntologyMolecularFunction	intramembrane lipid transporter activity	ANO4 ANO1 ANO5 ATP8A1 ANO3	6.14e-06	51	102	5	GO:0140303
GeneOntologyMolecularFunction	RNA nuclease activity	ERVK-6 ZC3H12A ERVK-7 ERVK-10 CNOT6 ERVK-8 ERVK-11	6.28e-06	136	102	7	GO:0004540
GeneOntologyMolecularFunction	endonuclease activity	ERVK-6 ZC3H12A ERVK-7 ERVK-10 N4BP2 ERVK-8 ERVK-11	6.28e-06	136	102	7	GO:0004519
GeneOntologyMolecularFunction	nuclease activity	ERVK-6 ZC3H12A ERVK-7 ERVK-10 CNOT6 N4BP2 ERVK-8 ERVK-11	2.45e-05	231	102	8	GO:0004518
GeneOntologyMolecularFunction	phospholipid transporter activity	ANO4 ANO1 ANO5 ATP8A1 ANO3	3.84e-05	74	102	5	GO:0005548
GeneOntologyMolecularFunction	odorant binding	OR8B4 OR9Q2 OR5B21 OR8G1 OR1K1 OR5AP2	4.81e-05	127	102	6	GO:0005549
GeneOntologyMolecularFunction	hydrolase activity, acting on ester bonds	ERVK-6 PLB1 ZC3H12A GDPD2 ERVK-7 ERVK-10 CNOT6 PTPRZ1 N4BP2 DDHD1 ERVK-8 DUSP10 ERVK-11 PHLPP2	6.08e-05	807	102	14	GO:0016788
GeneOntologyMolecularFunction	lipid transporter activity	ANO4 ABCC1 ANO1 ANO5 ATP8A1 SLC51A ANO3	6.63e-05	196	102	7	GO:0005319
GeneOntologyMolecularFunction	cadmium ion transmembrane transporter activity	SLC11A2 SLC11A1	7.73e-05	3	102	2	GO:0015086
GeneOntologyMolecularFunction	ligand-gated monoatomic anion channel activity	ANO4 ANO1 ANO5 ANO3	1.23e-04	50	102	4	GO:0099095
GeneOntologyMolecularFunction	catalytic activity, acting on RNA	ERVK-6 ZC3H12A ERVK-7 ERVK-10 CNOT6 ERVK-8 DDX23 ERVK-11 DHX29	2.86e-04	417	102	9	GO:0140098
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	ERVK-6 ERVK-7 ERVK-10 N4BP2 ERVK-8 ERVK-11 CDK7	3.95e-04	262	102	7	GO:0140097
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	ERVK-6 ZC3H12A ERVK-7 ERVK-10 CNOT6 N4BP2 ERVK-8 DDX23 ERVK-11 DHX29 CDK7	4.56e-04	645	102	11	GO:0140640
GeneOntologyMolecularFunction	tripeptide transmembrane transporter activity	ABCC1 SLC15A2	9.09e-04	9	102	2	GO:0042937
GeneOntologyMolecularFunction	transmembrane transporter activity	ANO4 SLC43A2 ABCC1 SLC11A2 ANO1 ANO5 SLC9A1 SLC11A1 ATP8A1 SLC15A2 CNGB3 SLC51A ANO3 UNC80 SLC23A3	9.41e-04	1180	102	15	GO:0022857
GeneOntologyMolecularFunction	chloride channel activity	ANO4 ANO1 ANO5 ANO3	9.89e-04	86	102	4	GO:0005254
GeneOntologyMolecularFunction	nucleotidyltransferase activity	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11	1.10e-03	152	102	5	GO:0016779
GeneOntologyMolecularFunction	manganese ion transmembrane transporter activity	SLC11A2 SLC11A1	1.13e-03	10	102	2	GO:0005384
GeneOntologyMolecularFunction	iron ion transmembrane transporter activity	SLC11A2 SLC11A1	1.38e-03	11	102	2	GO:0005381
GeneOntologyMolecularFunction	inorganic anion transmembrane transporter activity	ANO4 ABCC1 ANO1 ANO5 ANO3	1.85e-03	171	102	5	GO:0015103
GeneOntologyMolecularFunction	monoatomic anion channel activity	ANO4 ANO1 ANO5 ANO3	1.93e-03	103	102	4	GO:0005253
GeneOntologyMolecularFunction	transporter activity	ANO4 SLC43A2 ABCC1 SLC11A2 ANO1 ANO5 SLC9A1 SLC11A1 ATP8A1 SLC15A2 CNGB3 SLC51A ANO3 UNC80 SLC23A3	2.25e-03	1289	102	15	GO:0005215
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	ANO4 SLC11A2 ANO1 ANO5 SLC9A1 SLC11A1 ATP8A1 SLC15A2 CNGB3 ANO3 UNC80	2.41e-03	793	102	11	GO:0015075
GeneOntologyMolecularFunction	oligopeptide transmembrane transporter activity	ABCC1 SLC15A2	2.96e-03	16	102	2	GO:0035673
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	ERVK-6 CDC42BPG TRIO SCYL3 ERVK-7 ERVK-10 TRRAP N4BP2 NRK ERVK-8 ERVK-11 CDK7	2.98e-03	938	102	12	GO:0016772
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	ANO4 ANO1 ANO5 CNGB3 ANO3	3.13e-03	193	102	5	GO:0015276
GeneOntologyMolecularFunction	ligand-gated channel activity	ANO4 ANO1 ANO5 CNGB3 ANO3	3.42e-03	197	102	5	GO:0022834
GeneOntologyMolecularFunction	chloride transmembrane transporter activity	ANO4 ANO1 ANO5 ANO3	3.88e-03	125	102	4	GO:0015108
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR8B4 OR9Q2 OR5B21 PTH2R OR8G1 TAS2R8 RXFP2 MRGPRG OR1K1 OR4F21 OR5AP2	5.46e-03	884	102	11	GO:0004930
GeneOntologyBiologicalProcess	DNA integration	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11	3.34e-09	13	102	5	GO:0015074
GeneOntologyBiologicalProcess	DNA synthesis involved in DNA repair	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11	3.87e-06	48	102	5	GO:0000731
GeneOntologyBiologicalProcess	RNA-templated DNA biosynthetic process	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-11	5.73e-05	83	102	5	GO:0006278
Domain	Anoct_dimer	ANO4 ANO1 ANO5 ANO3	2.08e-08	7	94	4	PF16178
Domain	Anoct_dimer	ANO4 ANO1 ANO5 ANO3	2.08e-08	7	94	4	IPR032394
Domain	Anoctamin	ANO4 ANO1 ANO5 ANO3	1.23e-07	10	94	4	PF04547
Domain	Anoctamin	ANO4 ANO1 ANO5 ANO3	1.23e-07	10	94	4	IPR007632
Domain	Nramp	SLC11A2 SLC11A1	2.51e-05	2	94	2	PF01566
Domain	NRAMP_fam	SLC11A2 SLC11A1	2.51e-05	2	94	2	IPR001046
Domain	-	SCYL3 TRRAP NCAPG2 RIF1 STAG3 SYMPK	8.99e-04	222	94	6	1.25.10.10
Domain	ARM-type_fold	NBEAL1 SCYL3 TRRAP NCAPG2 RIF1 STAG3 SYMPK	1.62e-03	339	94	7	IPR016024
Domain	HEAT	SCYL3 NCAPG2 SYMPK	1.81e-03	48	94	3	PF02985
Domain	GPCR_Rhodpsn_7TM	OR8B4 OR9Q2 OR5B21 OR8G1 TAS2R8 RXFP2 MRGPRG OR1K1 OR4F21 OR5AP2	1.98e-03	670	94	10	IPR017452
Domain	CNH	CDC42BPG NRK	2.19e-03	14	94	2	SM00036
Domain	ARM-like	SCYL3 TRRAP NCAPG2 RIF1 STAG3 SYMPK	2.43e-03	270	94	6	IPR011989
Domain	G_PROTEIN_RECEP_F1_2	OR8B4 OR9Q2 OR5B21 OR8G1 TAS2R8 RXFP2 MRGPRG OR1K1 OR4F21 OR5AP2	2.48e-03	691	94	10	PS50262
Domain	GPCR_Rhodpsn	OR8B4 OR9Q2 OR5B21 OR8G1 TAS2R8 RXFP2 MRGPRG OR1K1 OR4F21 OR5AP2	2.51e-03	692	94	10	IPR000276
Domain	CNH	CDC42BPG NRK	2.52e-03	15	94	2	PF00780
Domain	CNH	CDC42BPG NRK	2.52e-03	15	94	2	PS50219
Domain	CNH_dom	CDC42BPG NRK	2.52e-03	15	94	2	IPR001180
Domain	HEAT	SCYL3 NCAPG2 SYMPK	3.12e-03	58	94	3	IPR000357
Domain	Olfact_rcpt	OR8B4 OR9Q2 OR5B21 OR8G1 OR1K1 OR4F21 OR5AP2	3.69e-03	393	94	7	IPR000725
Domain	SRCR	SSC4D TMPRSS3	4.95e-03	21	94	2	PF00530
Pathway	REACTOME_INDUCTION_OF_CELL_CELL_FUSION	ANO4 ANO1 ANO5 ANO3	4.08e-07	13	71	4	M46426
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	ANO4 SLC43A2 ABCC1 SLC11A2 ANO1 ANO5 SLC9A1 SLC11A1 ATP8A1 SLC15A2 ANO3 UNC80	1.36e-04	681	71	12	MM14985
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	ANO4 ANO1 ANO5 ANO3 UNC80	1.39e-04	99	71	5	MM14910
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	ANO4 ANO1 ANO5 ANO3 UNC80	1.92e-04	106	71	5	M27200
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	ANO4 ANO1 ANO5 ATP8A1 ANO3 UNC80	2.54e-04	176	71	6	MM15718
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	ANO4 SLC43A2 ABCC1 SLC11A2 ANO1 ANO5 SLC9A1 SLC11A1 ATP8A1 SLC15A2 ANO3 UNC80	2.80e-04	736	71	12	M27287
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	ANO4 ANO1 ANO5 ATP8A1 ANO3 UNC80	3.14e-04	183	71	6	M997
Pathway	REACTOME_LATE_SARS_COV_2_INFECTION_EVENTS	ANO4 ANO1 ANO5 ANO3	4.22e-04	70	71	4	M46438
Pubmed	Identification and characterization of TMEM16E and TMEM16F genes in silico.	ANO4 ANO1 ANO5 ANO3	1.08e-09	6	103	4	15067359
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-6 ERVK-7 ERVK-10 ERVK-8 ERVK-18 ERVK-25 ERVK-11	1.35e-08	94	103	7	21542922
Pubmed	Anoctamin/TMEM16 family members are Ca2+-activated Cl- channels.	ANO4 ANO1 ANO5 ANO3	1.50e-08	10	103	4	19015192
Pubmed	Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members.	ANO4 ANO1 ANO5 ANO3	1.50e-08	10	103	4	23532839
Pubmed	Structure and function of TMEM16 proteins (anoctamins).	ANO4 ANO1 ANO5 ANO3	1.50e-08	10	103	4	24692353
Pubmed	Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.	ERVK-6 ERVK-7 ERVK-10	1.01e-07	4	103	3	10469592
Pubmed	FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products.	ANO4 ANO1 ANO3	1.01e-07	4	103	3	12739008
Pubmed	Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.	ERVK-10 ERVK-18 ERVK-25 ERVK-11	2.15e-07	18	103	4	18664271
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-6 ERVK-7 ERVK-18	2.51e-07	5	103	3	12629516
Pubmed	ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins.	ANO4 ANO1 ANO5	8.75e-07	7	103	3	22075693
Pubmed	Anoctamins are a family of Ca2+-activated Cl- channels.	ANO4 ANO1 ANO5	1.40e-06	8	103	3	22946059
Pubmed	Cloning and characterization of a second human NRAMP gene on chromosome 12q13.	SLC11A2 SLC11A1	8.69e-06	2	103	2	7613023
Pubmed	SLC11A1 (NRAMP1) but not SLC11A2 (NRAMP2) polymorphisms are associated with susceptibility to tuberculosis in a high-incidence community in South Africa.	SLC11A2 SLC11A1	8.69e-06	2	103	2	15636493
Pubmed	Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.	STRC STRCP1	8.69e-06	2	103	2	11687802
Pubmed	Both Nramp1 and DMT1 are necessary for efficient macrophage iron recycling.	SLC11A2 SLC11A1	8.69e-06	2	103	2	20394798
Pubmed	Nramp1: a link between intracellular iron transport and innate resistance to intracellular pathogens.	SLC11A2 SLC11A1	8.69e-06	2	103	2	10577506
Pubmed	Identification of a tyrosine-based motif (YGSI) in the amino terminus of Nramp1 (Slc11a1) that is important for lysosomal targeting.	SLC11A2 SLC11A1	8.69e-06	2	103	2	16905747
Pubmed	Tlr5 is not primarily associated with susceptibility to Salmonella Typhimurium infection in MOLF/Ei mice.	SLC11A1 TLR5	8.69e-06	2	103	2	16688529
Pubmed	Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.	STRC STRCP1	8.69e-06	2	103	2	34910522
Pubmed	Mutation analysis of seven SLC family transporters for early-onset Parkinson's disease in Chinese population.	SLC11A2 SLC11A1	8.69e-06	2	103	2	33781609
Pubmed	A new inborn error of glycosylation due to a Cog8 deficiency reveals a critical role for the Cog1-Cog8 interaction in COG complex formation.	COG8 COG6	8.69e-06	2	103	2	17220172
Pubmed	Nutritional immunity: homology modeling of Nramp metal import.	SLC11A2 SLC11A1	8.69e-06	2	103	2	21948377
Pubmed	Interferon-alpha-induced endogenous superantigen. a model linking environment and autoimmunity.	ERVK-6 ERVK-18	8.69e-06	2	103	2	11672541
Pubmed	COG8 deficiency causes new congenital disorder of glycosylation type IIh.	COG8 COG6	8.69e-06	2	103	2	17331980
Pubmed	Evolution of differences in transport function in Slc11a family members.	SLC11A2 SLC11A1	8.69e-06	2	103	2	17932044
Pubmed	Identification and characterization of a second mouse Nramp gene.	SLC11A2 SLC11A1	8.69e-06	2	103	2	7789986
Pubmed	Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.	STRC STRCP1	2.60e-05	3	103	2	30801007
Pubmed	Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.	ERVK-6 ERVK-18	2.60e-05	3	103	2	10516026
Pubmed	HIV-1 controllers exhibit an enhanced antiretroviral innate state characterised by overexpression of p21 and MCPIP1 and silencing of ERVK-6 RNA expression.	ERVK-6 ZC3H12A	2.60e-05	3	103	2	39292108
Pubmed	Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.	ERVK-6 ERVK-11	2.60e-05	3	103	2	9971820
Pubmed	Candidate gene association study of solute carrier family 11a members 1 (SLC11A1) and 2 (SLC11A2) genes in Alzheimer's disease.	SLC11A2 SLC11A1	2.60e-05	3	103	2	15644277
Pubmed	The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic.	COG8 COG6	2.60e-05	3	103	2	11703943
Pubmed	Protein tyrosine phosphatase receptor type Z is involved in hippocampus-dependent memory formation through dephosphorylation at Y1105 on p190 RhoGAP.	ARHGAP35 PTPRZ1	2.60e-05	3	103	2	16513268
Pubmed	Diversity of Ca2+-activated K+ channel transcripts in inner ear hair cells.	SLC11A2 SLC11A1	2.60e-05	3	103	2	17097837
Pubmed	Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.	STRC STRCP1	5.19e-05	4	103	2	18849963
Pubmed	Associations between toll-like receptors and interleukin-4 in the lungs of patients with tuberculosis.	TLR5 IL4	5.19e-05	4	103	2	12600829
Pubmed	[IMMUNOGENETICS AND PROGRESSION OF CHRONIC VIRAL HEPATITES].	SLC11A1 IL4	5.19e-05	4	103	2	26281177
Pubmed	Target silencing of components of the conserved oligomeric Golgi complex impairs HIV-1 replication.	COG8 COG6	5.19e-05	4	103	2	25179963
Pubmed	Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.	ERVK-6 ERVK-10	5.19e-05	4	103	2	7983737
Pubmed	Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction.	ABCC1 SLC15A2	8.64e-05	5	103	2	12388627
Pubmed	Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.	ERVK-6 ERVK-7	8.64e-05	5	103	2	11401426
Pubmed	Ordered progression of stage-specific miRNA profiles in the mouse B2 B-cell lineage.	SLC9A1 DDHD1	8.64e-05	5	103	2	21403133
Pubmed	An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.	STRC STRCP1	8.64e-05	5	103	2	24920589
Pubmed	Expression patterns of the Tmem16 gene family during cephalic development in the mouse.	ANO1 ANO3	1.29e-04	6	103	2	19059364
Pubmed	Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp.	COG8 COG6	2.40e-04	8	103	2	11929878
Pubmed	The binary interacting network of the conserved oligomeric Golgi tethering complex.	COG8 COG6	2.40e-04	8	103	2	15047703
Pubmed	The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels.	ANO1 ANO3	2.40e-04	8	103	2	21984732
Pubmed	Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane.	STRC STRCP1	2.40e-04	8	103	2	21165971
Pubmed	Expression and function of epithelial anoctamins.	ANO1 ANO5	2.40e-04	8	103	2	20056604
Pubmed	Expression of TMEM16 paralogs during murine embryogenesis.	ANO1 ANO3	2.40e-04	8	103	2	18729231
Pubmed	Chagas' disease susceptibility/resistance: linkage disequilibrium analysis suggests epistasis between major histocompatibility complex and interleukin-10.	SLC11A1 IL4	2.40e-04	8	103	2	15191519
Pubmed	Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function.	COG8 COG6	2.40e-04	8	103	2	11980916
Pubmed	COG Complex Complexities: Detailed Characterization of a Complete Set of HEK293T Cells Lacking Individual COG Subunits.	COG8 COG6	2.40e-04	8	103	2	27066481
Pubmed	Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9.	TLR5 IL4	2.40e-04	8	103	2	27977701
Pubmed	Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.	CYP1A2 CHST5 ABCC1 SLC15A2 UGT2B15	2.82e-04	193	103	5	19343046
Pubmed	Congenital Disorders of N-Linked Glycosylation and Multiple Pathway Overview	COG8 COG6 ALG8	3.06e-04	44	103	3	20301507
Pubmed	Characterization of a cluster comprising approximately 100 odorant receptor genes in mouse.	OR8B4 OR8G1	3.85e-04	10	103	2	11130974
Pubmed	Clarin-2 is essential for hearing by maintaining stereocilia integrity and function.	STRC STRCP1	4.69e-04	11	103	2	31448880
Pubmed	Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.	STRC STRCP1	4.69e-04	11	103	2	31776257
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR8B4 OR9Q2 OR5B21 OR8G1 OR4F21 OR5AP2	5.39e-04	340	103	6	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR8B4 OR9Q2 OR5B21 OR8G1 OR4F21 OR5AP2	5.39e-04	340	103	6	11802173
Pubmed	Genetic determinants of acute inflammation regulate Salmonella infection and modulate Slc11a1 gene (formerly Nramp1) effects in selected mouse lines.	SLC11A1 IL4	5.62e-04	12	103	2	17035062
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-6 ERVK-8	5.62e-04	12	103	2	14557543
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR8B4 OR9Q2 OR5B21 OR8G1 OR4F21 OR5AP2	5.64e-04	343	103	6	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR8B4 OR9Q2 OR5B21 OR8G1 OR4F21 OR5AP2	5.91e-04	346	103	6	14611657
Pubmed	Protocadherins.	PCDHB6 PCDHB2	6.63e-04	13	103	2	12231349
Pubmed	Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5.	TLR5 IL4	6.63e-04	13	103	2	18516037
Pubmed	Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.	SMG8 NOTCH4	7.72e-04	14	103	2	23620142
Pubmed	Notch signaling regulates remodeling and vessel diameter in the extraembryonic yolk sac.	PGF NOTCH4	1.01e-03	16	103	2	21352545
Pubmed	Variation in immune response genes and chronic Q fever. Concepts: preliminary test with post-Q fever fatigue syndrome.	SLC11A1 IL4	1.15e-03	17	103	2	12595908
Pubmed	Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1.	STRC STRCP1	1.15e-03	17	103	2	20856818
Pubmed	Genetic control of diabetogenesis in NOD/Lt mice. Development and analysis of congenic stocks.	CYP1A2 NOTCH4	1.44e-03	19	103	2	2576007
Pubmed	The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number.	PCDHB6 PCDHB2	1.59e-03	20	103	2	11322959
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	ABCC1 KREMEN2 ZSCAN32 RIF1 SLC9A1 PRMT5 TMPRSS3 DDX23 DHX29	1.73e-03	925	103	9	28986522
Pubmed	Wnt signaling regulates ion channel expression to promote smooth muscle and cartilage formation in developing mouse trachea.	ANO4 ANO1	2.11e-03	23	103	2	37873566
Pubmed	Loss of function of the maternal membrane oestrogen receptor ERα alters expansion of trophoblast cells and impacts mouse fertility.	PGF NOTCH4	2.11e-03	23	103	2	36239412
Pubmed	Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.	CDC42BPG ABCC1 UBE4A SMG8	2.19e-03	183	103	4	31932471
Pubmed	Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer.	CYP1A2 UGT2B15	2.49e-03	25	103	2	17507624
Pubmed	Genetic variation in metabolizing enzyme and transporter genes: comprehensive assessment in 3 major East Asian subpopulations with comparison to Caucasians and Africans.	CYP1A2 SLC15A2	2.90e-03	27	103	2	20173083
GeneFamily	Anoctamins	ANO4 ANO1 ANO5 ANO3	3.56e-08	10	67	4	865
GeneFamily	Components of oligomeric golgi complex	COG8 COG6	3.73e-04	8	67	2	493
GeneFamily	Solute carriers	SLC43A2 SLC11A2 SLC9A1 SLC11A1 SLC15A2 SLC51A SLC23A3	6.34e-04	395	67	7	752
ToppCell	343B-Lymphocytic-CD4_T-cell-Treg_cell_1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TTC39B ABCC1 TRRAP UBE4A DDHD1 LRRC75A SYMPK	1.44e-07	183	96	7	807d64deaf4e50dccf6f831f88578a6d903c1421
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANO4 ANO1 SEZ6L2 PTH2R PTPRZ1 N4BP2	3.76e-06	192	96	6	025fac36b862f9ca7f96fb4a1946c44ba7cbc382
ToppCell	10x5'v1-week_17-19-Myeloid_neutrophil-granulo-eo/baso/mast\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	TTC39B SLC11A2 PTH2R UTS2 DUSP10 IL4	4.11e-06	195	96	6	f1f48e2e57b2282572959b152aad4bee05143f03
Disease	Congenital disorder of glycosylation	MAN2C1 COG8 COG6 ALG8	5.04e-06	38	88	4	cv:C0282577
Disease	autosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)	STRC STRCP1	8.79e-06	2	88	2	DOID:0110471 (implicated_via_orthology)
Disease	Pneumoconiosis	PTPRZ1 TMPRSS3 IL4	9.11e-06	14	88	3	C0032273
Disease	Bagassosis	PTPRZ1 TMPRSS3 IL4	9.11e-06	14	88	3	C0004681
Disease	X-25937 measurement	UGT2B15 SLC51A	5.26e-05	4	88	2	EFO_0800937
Disease	cysteinylglycine disulfide measurement	ABCC1 SLC23A3	5.26e-05	4	88	2	EFO_0800049
Disease	thiamine measurement	ANO5 N4BP2	3.90e-04	10	88	2	EFO_0010540
Disease	ankylosing spondylitis (is_marker_for)	PGF TLR5	3.90e-04	10	88	2	DOID:7147 (is_marker_for)
Disease	plasma N-desmethylclozapine measurement	CYP1A2 UGT2B15	4.75e-04	11	88	2	EFO_0600039
Disease	5alpha-androstan-3beta,17beta-diol monosulfate (2) measurement	UGT2B15 SLC51A	5.69e-04	12	88	2	EFO_0800291
Disease	asthma (biomarker_via_orthology)	UTS2 PRMT5 IL4	7.38e-04	59	88	3	DOID:2841 (biomarker_via_orthology)
Disease	5alpha-androstan-3alpha,17alpha-diol monosulfate measurement	UGT2B15 SLC51A	7.82e-04	14	88	2	EFO_0800283
Disease	5alpha-androstan-3alpha,17beta-diol monosulfate (1) measurement	UGT2B15 SLC51A	1.30e-03	18	88	2	EFO_0800288
Disease	multiple sclerosis (is_implicated_in)	SLC11A1 IL4 NOTCH4	1.37e-03	73	88	3	DOID:2377 (is_implicated_in)
Disease	carotid artery disease (is_marker_for)	PGF UTS2	1.45e-03	19	88	2	DOID:3407 (is_marker_for)
Disease	unipolar depression, alcohol dependence	CNOT6 RIF1 STAG3	1.66e-03	78	88	3	EFO_0003761, MONDO_0007079
Disease	X-24947 measurement	UGT2B15 SLC51A	1.95e-03	22	88	2	EFO_0800910
Disease	Autism Spectrum Disorders	DIPK2A DDHD1 UNC80	2.12e-03	85	88	3	C1510586
Disease	systemic scleroderma (is_implicated_in)	SLC11A1 NOTCH4	2.33e-03	24	88	2	DOID:418 (is_implicated_in)
Disease	cholelithiasis	TTC39B ANO1 SYMPK	2.34e-03	88	88	3	EFO_0004799
Disease	epiandrosterone sulfate measurement	UGT2B15 SLC51A	2.52e-03	25	88	2	EFO_0021120
Disease	myeloperoxidase measurement	SMG8 NOTCH4	2.73e-03	26	88	2	EFO_0005243
Disease	psychosis predisposition measurement	ABCC1 CNOT6	2.73e-03	26	88	2	EFO_0008337

Protein segments in the cluster

Peptide	Gene	Start	Entry
FVASFPLAPLLALIN	ANO5	686	Q75V66
TAELLQQLFPPLLDA	CCDC142	391	Q17RM4
FVAAFPLAPLLALLN	ANO4	726	Q32M45
APFLLEDPANQFLRL	C3orf85	21	A0A1B0GTC6
PQFRNIEGAVLIFLP	DHX29	861	Q7Z478
LPSHFQQQLLFLLPE	ASXL1	276	Q8IXJ9
FLFIALLQQIPDVSP	ATP8A1	81	Q9Y2Q0
AFPLAPLLALLNNII	ANO3	771	Q9BYT9
QLFLLLFEPGNADIL	NBEAL1	1126	Q6ZS30
PLNNDVLNTILLFLF	RAB3GAP1	401	Q15042
FLAILLQQLEFSVPP	CYP1A2	471	P05177
FLNTPIAANLPIGFL	INTS15	221	Q96N11
FALYPLLNEAAPLAL	CDC42BPG	1246	Q6DT37
LPFQVLLENPLQFFQ	PCDHB2	106	Q9Y5E7
GLSEQPELQLPLFLL	OR8B4	16	Q96RC9
NNEINFIFCDLPPLL	OR9Q2	171	Q8NGE9
GLSEQPELQLPLFLL	OR8G1	16	Q15617
LAIFDAVLTPFLNPV	OR4F21	271	O95013
TDDPNLQIPLLLAFL	OR5B21	16	A6NL26
ADPGLADLPQQLLFV	GRWD1	396	Q9BQ67
ISALFALLQQPLFLA	SLC43A2	491	Q8N370
NVDIFSLPQPFLLSL	LRRC75A	271	Q8NAA5
ELTPILPFLFLGNEQ	DUSP10	321	Q9Y6W6
DFPPLACFLNNILVA	COG8	431	Q96MW5
FLIDLLQPNQAEFPL	LANCL3	401	Q6ZV70
LQGFLFLLFLPLLQP	KREMEN2	6	Q8NCW0
LNVLQSLLLPFAVLP	SLC11A1	431	P49279
FLNVLQSLQLPFALI	SLC11A2	441	P49281
QSLQLPFALIPILTF	SLC11A2	446	P49281
QFLNLPYQDLPLLDI	GDPD2	421	Q9HCC8
FPLAPLFALLNNIIE	ANO1	746	Q5XXA6
LDLNPNRFPIFAALL	FAM120A	226	Q9NZB2
ALDPFILLNLLPNST	PTPRZ1	211	P23471
LAILEQGFDPPIIIF	DDX23	656	Q9BUQ8
NPDLQGVLFALFLLI	OR5AP2	26	Q8NGF4
IDPLAPLQLLIFATA	ERVK-7	331	P63135
IDPLAPLQLLIFATA	ERVK-6	331	Q9BXR3
SPGQQRPLFVLFLLL	OR1K1	21	Q8NGR3
QPLLNFLLPVFSPLA	MRGPRG	221	Q86SM5
FALFQVLLILTALQP	SLC51A	256	Q86UW1
VPLLLNQLVFAEPVA	SCYL3	291	Q8IZE3
IDPLAPLQLLIFATA	ERVK-18	331	Q9QC07
APDNLLIPQLNFLLS	COG6	591	Q9Y2V7
LQLGLLFPPAEALQV	ECI1	206	P42126
QLLPPLFFLLACAGN	IL4	6	P05112
DDLLDLIQGLFLFNP	CDK7	266	P50613
LLTLAFNPEPLVLQS	DIPK2A	206	Q8NDZ4
YLLQFENPALLVSPL	DPY19L4	306	Q7Z388
YLGLPAFLLPLNQED	PRMT5	116	O14744
QLVENLFSLPLDVPF	CYP26C1	216	Q6V0L0
IQAAYSLNFPLLALP	MAN2C1	921	Q9NTJ4
LQESFFNLPQLLFPE	DDHD1	816	Q8NEL9
VLNPLLVLIFIPLFD	SLC15A2	346	Q16348
AQLELLLPFLPQVNG	CNOT6	536	Q9ULM6
PFQNILFIFLLSVLP	FTH1P19	171	P0C7X4
CVLPFQVLLENPLQF	PCDHB6	101	Q9Y5E3
LAIFDAVLTPFLNPV	OR4F3;	271	Q6IEY1
LALFNILRFPLNILP	ABCC1	586	P33527
PLCNLQPLEALFVIL	NRK	256	Q7Z2Y5
CPPRLLFLFQLNGAL	SMG8	261	Q8ND04
QPLALLPFSLDLLFQ	RUSC2	1161	Q8N2Y8
FIGFLNPLLSLPLLD	UTS2	11	O95399
LNLSAPILNIPIVQF	TMEM41A	171	Q96HV5
PILNIPIVQFFFSVL	TMEM41A	176	Q96HV5
LVLTLFAPQPLLLAQ	TMEM140	91	Q9NV12
PALFLIQLIFNNFLE	RIF1	581	Q5UIP0
VIFFLPVNSALNPIL	RXFP2	676	Q8WXD0
PANPLLLSLRFEAFE	SEZ6L2	446	Q6UXD5
PFFQNIQLPVLADGL	PLB1	976	Q6P1J6
VVLSPPALDQQLFAL	NOTCH4	1301	Q99466
LAALPLAFEALIPNL	ARHGAP35	341	Q9NRY4
SQLFIDLSPLIPFLA	STRC	796	Q7RTU9
VQAPSLEFLIPALVL	SLC23A3	111	Q6PIS1
LSLGPFLALNQLPQV	ALG8	251	Q9BVK2
FNLQVLYPLLSDPAL	CHST5	201	Q9GZS9
ALLFVEAFPIRDPNL	NCAPG2	351	Q86XI2
LPEPQTLFEIVFQLL	CNGB3	411	Q9NQW8
IDPLAPLQLLIFATA	ERVK-25	331	P63136
VAAQILSLLPLKFFP	TMPRSS3	36	P57727
LFLLFNEGLTNLPLE	TMEM17	126	Q86X19
FPQLLDPQQLAAEIL	ZC3H12A	576	Q5D1E8
LLAPFLQQFPNGSLV	TTC39B	381	Q5VTQ0
LFPLAVEAFLQALPL	TTC24	251	A2A3L6
LQLFASVAPLLEFPD	UNC80	2271	Q8N2C7
LDLPVLFPNRLGFEF	ZSCAN32	401	Q9NX65
FPEILQLPQIQFVDL	PHLPP2	706	Q6ZVD8
NQPPNLAFLELLSEF	STAG3	1001	Q9UJ98
LFPCFLQLLAGLALP	PGF	6	P49763
FLPQALSFLLLLPLA	SSC4D	31	Q8WTU2
IDPLAPLQLLIFATA	ERVK-10	331	P10266
IDPLAPLQLLIFATA	ERVK-8	331	P63133
IDPLAPLQLLIFATA	ERVK-11	331	Q9UQG0
LQSDVFFLFLLPPII	SLC9A1	156	P19634
LPAAAFLLVLLPAAA	TMEM88B	61	A6NKF7
PILAAIGLNFILFLN	PTH2R	321	P49190
FLQPLLTPDNVANLV	SYMPK	401	Q92797
SQLFIDLSPLIPFLA	STRCP1	796	A6NGW2
EPLTLFNLFAIVPFI	TAS2R8	181	Q9NYW2
GLTFQLPLPELEIFQ	ZNF766	111	Q5HY98
LEAMNPPLFLRFLNL	UBE4A	776	Q14139
PPLFLRFLNLLMNDA	UBE4A	781	Q14139
PCGELLAELFNIPFL	UGT2B15	156	P54855
FPFLEQLQLLELGSQ	TLR5	66	O60602
YQEFLPLLPNLLQGL	TRRAP	776	Q9Y4A5
QLLGNPEFAAPEIIL	TRIO	2951	O75962
IPAALLPFQGSLIFQ	NACAD	306	O15069
LELALPPELAFQLNE	N4BP2	1376	Q86UW6