Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF430 ZNF708 ZBTB49 ZNF492 ZSCAN5B ZNF211 ZNF718 ZNF460 PATZ1 ZNF253 ZNF735 ZNF485 ZNF267 ZNF816 ZBTB47 ZNF814 ZNF534 ZNF479 ZNF480 ZNF880 NR5A1 ZNF860 ZNF251 ZNF840P ZNF681 ZNF77	1.12e-10	1412	86	26	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF430 ZNF708 ZBTB49 ZNF492 ZSCAN5B ZNF211 ZNF718 ZNF460 PATZ1 ZNF253 ZNF735 ZNF485 ZNF267 ZNF816 ZNF814 ZNF534 ZNF479 ZNF480 ZNF880 NR5A1 ZNF860 ZNF251 ZNF840P ZNF681	2.78e-10	1244	86	24	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF430 ZNF708 ZBTB49 ZNF492 ZSCAN5B ZNF211 ZNF718 ZNF460 PATZ1 ZNF253 ZNF735 ZNF485 ZNF267 ZNF816 ZNF814 ZNF534 ZNF479 ZNF480 ZNF880 NR5A1 ZNF860 ZNF251 ZNF840P ZNF681	4.29e-10	1271	86	24	GO:0000987
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF430 ZNF708 ZBTB49 ZNF492 ZSCAN5B ZNF211 ZNF718 ZNF460 PATZ1 ZNF253 ZNF735 ZNF485 ZNF267 ZNF816 ZNF814 ZNF534 ZNF479 ZNF480 ZNF880 NR5A1 ZNF860 ZNF251 ZNF840P ZNF681 ZNF77	1.27e-09	1459	86	25	GO:0000977
GeneOntologyMolecularFunction	peptide-glutamate-alpha-N-acetyltransferase activity	NAA11 NAA10	1.83e-05	2	86	2	GO:1990190
GeneOntologyMolecularFunction	adenosine-phosphate deaminase activity	AMPD2 AMPD3	5.48e-05	3	86	2	GO:0047623
GeneOntologyMolecularFunction	AMP deaminase activity	AMPD2 AMPD3	5.48e-05	3	86	2	GO:0003876
GeneOntologyMolecularFunction	peptide-serine-alpha-N-acetyltransferase activity	NAA11 NAA10	5.48e-05	3	86	2	GO:1990189
GeneOntologyMolecularFunction	alpha-1,4-glucosidase activity	GANC MGAM2	1.82e-04	5	86	2	GO:0004558
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	USP8 USP9Y USP47 VCPIP1 SENP5	3.15e-04	137	86	5	GO:0019783
GeneOntologyMolecularFunction	alpha-glucosidase activity	GANC MGAM2	3.80e-04	7	86	2	GO:0090599
GeneOntologyMolecularFunction	peptide alpha-N-acetyltransferase activity	NAA11 NAA10	5.05e-04	8	86	2	GO:0004596
GeneOntologyMolecularFunction	siRNA binding	TLR9 DICER1	1.18e-03	12	86	2	GO:0035197
GeneOntologyMolecularFunction	cysteine-type peptidase activity	USP8 USP9Y USP47 VCPIP1 SENP5	1.45e-03	192	86	5	GO:0008234
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	USP8 USP9Y USP47 VCPIP1	1.49e-03	114	86	4	GO:0004843
GeneOntologyMolecularFunction	glucosidase activity	GANC MGAM2	1.86e-03	15	86	2	GO:0015926
GeneOntologyMolecularFunction	deubiquitinase activity	USP8 USP9Y USP47 VCPIP1	2.03e-03	124	86	4	GO:0101005
GeneOntologyCellularComponent	NatA complex	NAA11 NAA10	1.66e-04	5	86	2	GO:0031415
Domain	KRAB	ZNF430 ZNF708 ZNF492 ZNF211 ZNF718 ZNF460 ZNF253 ZNF735 ZNF485 ZNF267 ZNF816 ZNF814 ZNF534 ZNF479 ZNF480 ZNF880 ZNF860 ZNF251 ZNF681 ZNF77	1.19e-16	358	85	20	PS50805
Domain	KRAB	ZNF430 ZNF708 ZNF492 ZNF211 ZNF718 ZNF460 ZNF253 ZNF735 ZNF485 ZNF267 ZNF816 ZNF814 ZNF534 ZNF479 ZNF480 ZNF880 ZNF860 ZNF251 ZNF681 ZNF77	1.19e-16	358	85	20	PF01352
Domain	zf-C2H2_6	ZBTB49 ZNF492 ZSCAN5B ZNF211 ZNF718 PATZ1 ZNF253 ZNF735 ZNF267 ZNF816 ZBTB47 ZNF814 ZNF479 ZNF480 ZNF880 ZNF860 ZNF251 ZNF681 ZNF77	1.76e-16	314	85	19	PF13912
Domain	-	ZNF430 ZNF708 ZBTB49 ZNF492 ZSCAN5B ZNF211 ZNF718 ZNF460 PATZ1 ZNF253 ZNF735 ZNF485 ZNF267 ZNF816 ZBTB47 ZNF814 ZNF534 ZNF479 ZNF480 ZNF880 ZNF860 ZNF831 ZNF251 ZNF681 ZNF77	1.87e-16	679	85	25	3.30.160.60
Domain	KRAB	ZNF430 ZNF708 ZNF492 ZNF211 ZNF718 ZNF460 ZNF253 ZNF735 ZNF485 ZNF267 ZNF816 ZNF814 ZNF534 ZNF479 ZNF480 ZNF880 ZNF860 ZNF251 ZNF681 ZNF77	2.14e-16	369	85	20	SM00349
Domain	KRAB	ZNF430 ZNF708 ZNF492 ZNF211 ZNF718 ZNF460 ZNF253 ZNF735 ZNF485 ZNF267 ZNF816 ZNF814 ZNF534 ZNF479 ZNF480 ZNF880 ZNF860 ZNF251 ZNF681 ZNF77	2.26e-16	370	85	20	IPR001909
Domain	Znf_C2H2/integrase_DNA-bd	ZNF430 ZNF708 ZBTB49 ZNF492 ZSCAN5B ZNF211 ZNF718 ZNF460 PATZ1 ZNF253 ZNF735 ZNF485 ZNF267 ZNF816 ZBTB47 ZNF814 ZNF534 ZNF479 ZNF480 ZNF880 ZNF860 ZNF831 ZNF251 ZNF681 ZNF77	3.11e-16	694	85	25	IPR013087
Domain	zf-C2H2	ZNF430 ZNF708 ZBTB49 ZNF492 ZSCAN5B ZNF211 ZNF718 ZNF460 PATZ1 ZNF253 ZNF735 ZNF485 ZNF267 ZNF816 ZBTB47 ZNF814 ZNF534 ZNF479 ZNF480 ZNF880 ZNF860 ZNF251 ZNF681 ZNF77	3.32e-15	693	85	24	PF00096
Domain	ZINC_FINGER_C2H2_2	ZNF430 ZNF708 ZBTB49 ZNF492 ZSCAN5B ZNF211 ZNF718 ZNF460 PATZ1 ZNF253 ZNF735 ZNF485 ZNF267 ZNF816 ZBTB47 ZNF814 ZNF534 ZNF479 ZNF480 ZNF880 ZNF860 ZNF831 ZNF251 ZNF681 ZNF77	3.97e-15	775	85	25	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF430 ZNF708 ZBTB49 ZNF492 ZSCAN5B ZNF211 ZNF718 ZNF460 PATZ1 ZNF253 ZNF735 ZNF485 ZNF267 ZNF816 ZBTB47 ZNF814 ZNF534 ZNF479 ZNF480 ZNF880 ZNF860 ZNF831 ZNF251 ZNF681 ZNF77	4.21e-15	777	85	25	PS00028
Domain	Znf_C2H2-like	ZNF430 ZNF708 ZBTB49 ZNF492 ZSCAN5B ZNF211 ZNF718 ZNF460 PATZ1 ZNF253 ZNF735 ZNF485 ZNF267 ZNF816 ZBTB47 ZNF814 ZNF534 ZNF479 ZNF480 ZNF880 ZNF860 ZNF831 ZNF251 ZNF681 ZNF77	7.32e-15	796	85	25	IPR015880
Domain	Znf_C2H2	ZNF430 ZNF708 ZBTB49 ZNF492 ZSCAN5B ZNF211 ZNF718 ZNF460 PATZ1 ZNF253 ZNF735 ZNF485 ZNF267 ZNF816 ZBTB47 ZNF814 ZNF534 ZNF479 ZNF480 ZNF880 ZNF860 ZNF831 ZNF251 ZNF681 ZNF77	9.46e-15	805	85	25	IPR007087
Domain	ZnF_C2H2	ZNF430 ZNF708 ZBTB49 ZNF492 ZSCAN5B ZNF211 ZNF718 ZNF460 PATZ1 ZNF253 ZNF735 ZNF485 ZNF267 ZNF816 ZBTB47 ZNF814 ZNF534 ZNF479 ZNF480 ZNF880 ZNF860 ZNF831 ZNF251 ZNF681 ZNF77	1.03e-14	808	85	25	SM00355
Domain	AMPD	AMPD2 AMPD3	6.12e-05	3	85	2	IPR006329
Domain	A/AMP_deam_AS	AMPD2 AMPD3	1.22e-04	4	85	2	IPR006650
Domain	A_deaminase	AMPD2 AMPD3	3.03e-04	6	85	2	PF00962
Domain	Glyco_hydro_31_AS	GANC MGAM2	3.03e-04	6	85	2	IPR030458
Domain	A_DEAMINASE	AMPD2 AMPD3	3.03e-04	6	85	2	PS00485
Domain	A/AMP_deaminase_dom	AMPD2 AMPD3	3.03e-04	6	85	2	IPR001365
Domain	Glyco_hydro_31	GANC MGAM2	4.24e-04	7	85	2	IPR000322
Domain	Glyco_hydro_31	GANC MGAM2	4.24e-04	7	85	2	PF01055
Domain	GLYCOSYL_HYDROL_F31_1	GANC MGAM2	4.24e-04	7	85	2	PS00129
Domain	BTB	ZBTB49 KCTD13 PATZ1 ZBTB47 KCNS2	1.38e-03	180	85	5	SM00225
Domain	TTL	TTLL12 TTLL4	1.55e-03	13	85	2	PS51221
Domain	TTL/TTLL_fam	TTLL12 TTLL4	1.55e-03	13	85	2	IPR004344
Domain	TTL	TTLL12 TTLL4	1.55e-03	13	85	2	PF03133
Domain	BTB/POZ_dom	ZBTB49 KCTD13 PATZ1 ZBTB47 KCNS2	1.56e-03	185	85	5	IPR000210
Domain	SKP1/BTB/POZ	ZBTB49 KCTD13 PATZ1 ZBTB47 KCNS2	1.72e-03	189	85	5	IPR011333
Domain	Gal_mutarotase_SF_dom	GANC MGAM2	2.66e-03	17	85	2	IPR011013
Domain	USP_CS	USP8 USP9Y USP47	3.39e-03	66	85	3	IPR018200
Domain	USP_1	USP8 USP9Y USP47	4.00e-03	70	85	3	PS00972
Domain	UCH	USP8 USP9Y USP47	4.16e-03	71	85	3	PF00443
Domain	USP_2	USP8 USP9Y USP47	4.16e-03	71	85	3	PS00973
Domain	USP_3	USP8 USP9Y USP47	4.33e-03	72	85	3	PS50235
Domain	USP_dom	USP8 USP9Y USP47	4.33e-03	72	85	3	IPR028889
Domain	Peptidase_C19_UCH	USP8 USP9Y USP47	4.33e-03	72	85	3	IPR001394
Domain	Acetyltransf_1	NAA11 NAA10	4.87e-03	23	85	2	PF00583
Domain	Spectrin	SYNE1 SPTA1	4.87e-03	23	85	2	PF00435
Domain	Metal_Hydrolase	AMPD2 AMPD3	5.29e-03	24	85	2	IPR032466
Domain	GNAT	NAA11 NAA10	5.74e-03	25	85	2	PS51186
Domain	GNAT_dom	NAA11 NAA10	5.74e-03	25	85	2	IPR000182
Domain	EFh	VSNL1 SLC25A12 SPTA1 HPCAL4	5.87e-03	158	85	4	SM00054
Domain	BTB	ZBTB49 KCTD13 PATZ1 ZBTB47	6.14e-03	160	85	4	PS50097
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF430 ZNF708 ZNF211 ZNF718 ZNF460 ZNF253 ZNF485 ZNF267 ZNF480 ZNF681 ZNF77	1.26e-12	181	88	11	37372979
Pubmed	The amplified mouse squamous cell carcinoma antigen gene locus contains a serpin (Serpinb3b) that inhibits both papain-like cysteine and trypsin-like serine proteinases.	SERPINB3 SERPINB4	6.33e-06	2	88	2	15203214
Pubmed	Increased Th1 immune response in SERPINB3 transgenic mice during acute liver failure.	SERPINB3 SERPINB4	6.33e-06	2	88	2	23354406
Pubmed	Cloning, characterization, and expression analysis of the novel acetyltransferase retrogene Ard1b in the mouse.	NAA11 NAA10	6.33e-06	2	88	2	19246321
Pubmed	Serpin B4 isoform overexpression is associated with aberrant epithelial proliferation and lung cancer in idiopathic pulmonary fibrosis.	SERPINB3 SERPINB4	6.33e-06	2	88	2	22406480
Pubmed	AMPD2 regulates GTP synthesis and is mutated in a potentially treatable neurodegenerative brainstem disorder.	AMPD2 AMPD3	6.33e-06	2	88	2	23911318
Pubmed	Recurrent SERPINB3 and SERPINB4 mutations in patients who respond to anti-CTLA4 immunotherapy.	SERPINB3 SERPINB4	6.33e-06	2	88	2	27668655
Pubmed	Isolation of two human cDNAs, HLP3 and HLP4, homologous to the neuron-specific calcium-binding protein genes.	VSNL1 HPCAL4	6.33e-06	2	88	2	10520747
Pubmed	Characterization of novel squamous cell carcinoma antigen-related molecules in mice.	SERPINB3 SERPINB4	6.33e-06	2	88	2	15504361
Pubmed	SCCA2-like serpins mediate genetic predisposition to skin tumors.	SERPINB3 SERPINB4	6.33e-06	2	88	2	12702576
Pubmed	Serpinb3 is overexpressed in the liver in presence of iron overload.	SERPINB3 SERPINB4	6.33e-06	2	88	2	28935635
Pubmed	Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins.	SERPINB3 SERPINB4	6.33e-06	2	88	2	35022507
Pubmed	IRAK4 is essential for TLR9-induced suppression of Epstein-Barr virus BZLF1 transcription in Akata Burkitt's lymphoma cells.	IRAK4 TLR9	6.33e-06	2	88	2	29088270
Pubmed	Overexpression of SERPIN B3 promotes epithelial proliferation and lung fibrosis in mice.	SERPINB3 SERPINB4	6.33e-06	2	88	2	21403642
Pubmed	AMP deaminase 3 plays a critical role in remote reperfusion lung injury.	AMPD2 AMPD3	6.33e-06	2	88	2	23542464
Pubmed	Identification of a novel human member of the DEAD box protein family.	DDX42 DICER1	6.33e-06	2	88	2	10727850
Pubmed	SERPINB3/B4 contributes to early inflammation and barrier dysfunction in an experimental murine model of atopic dermatitis.	SERPINB3 SERPINB4	6.33e-06	2	88	2	25111616
Pubmed	Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoter.	SERPINB3 SERPINB4	6.33e-06	2	88	2	11267667
Pubmed	TLR9 activation induces normal neutrophil responses in a child with IRAK-4 deficiency: involvement of the direct PI3K pathway.	IRAK4 TLR9	6.33e-06	2	88	2	17878374
Pubmed	Squamous Cell Carcinoma Antigen-encoding Genes SERPINB3/B4 as Potentially Useful Markers for the Stratification of HNSCC Tumours.	SERPINB3 SERPINB4	6.33e-06	2	88	2	29491058
Pubmed	Squamous cell carcinoma antigen production in nasal inverted papilloma.	SERPINB3 SERPINB4	6.33e-06	2	88	2	23168150
Pubmed	The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases.	SERPINB3 SERPINB4	6.33e-06	2	88	2	11863458
Pubmed	IgM-linked SerpinB3 and SerpinB4 in sera of patients with chronic liver disease.	SERPINB3 SERPINB4	6.33e-06	2	88	2	22808225
Pubmed	Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma.	SERPINB3 SERPINB4	6.33e-06	2	88	2	14970861
Pubmed	Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas.	SERPINB3 SERPINB4	6.33e-06	2	88	2	10653592
Pubmed	Serum squamous cell carcinoma antigen as an early indicator of response during therapy of cervical cancer.	SERPINB3 SERPINB4	6.33e-06	2	88	2	29112685
Pubmed	Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells.	SERPINB3 SERPINB4	6.33e-06	2	88	2	10956412
Pubmed	Tumor-related protein, the squamous cell carcinoma antigen binds to the intracellular protein carbonyl reductase.	SERPINB3 SERPINB4	6.33e-06	2	88	2	20428762
Pubmed	SerpinB3 as a Pro-Inflammatory Mediator in the Progression of Experimental Non-Alcoholic Fatty Liver Disease.	SERPINB3 SERPINB4	6.33e-06	2	88	2	35874657
Pubmed	Serpin B3/B4, activated by STAT3, promote survival of squamous carcinoma cells.	SERPINB3 SERPINB4	1.90e-05	3	88	2	19070595
Pubmed	Naa12 compensates for Naa10 in mice in the amino-terminal acetylation pathway.	NAA11 NAA10	1.90e-05	3	88	2	34355692
Pubmed	Cloning of human AMP deaminase isoform E cDNAs. Evidence for a third AMPD gene exhibiting alternatively spliced 5'-exons.	AMPD2 AMPD3	1.90e-05	3	88	2	1400401
Pubmed	Platelet AMP deaminase. Purification and kinetic studies.	AMPD2 AMPD3	1.90e-05	3	88	2	7287721
Pubmed	A murine ortholog of the human serpin SCCA2 maps to chromosome 1 and inhibits chymotrypsin-like serine proteinases.	SERPINB3 SERPINB4	1.90e-05	3	88	2	9828132
Pubmed	Anti-apoptotic effects of SERPIN B3 and B4 via STAT6 activation in macrophages after infection with Toxoplasma gondii.	SERPINB3 SERPINB4	1.90e-05	3	88	2	22451727
Pubmed	A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene.	SERPINB3 SERPINB4	1.90e-05	3	88	2	7724531
Pubmed	Differentially expressed proteins in human breast cancer cells sensitive and resistant to paclitaxel.	SERPINB3 SERPINB4	1.90e-05	3	88	2	24898082
Pubmed	A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma.	SERPINB3 SERPINB4	1.90e-05	3	88	2	21126757
Pubmed	Novel aspects of tetramer assembly and N-terminal domain structure and function are revealed by recombinant expression of human AMP deaminase isoforms.	AMPD2 AMPD3	1.90e-05	3	88	2	9857047
Pubmed	SOX7 inhibits the malignant progression of bladder cancer via the DNMT3B/CYGB axis.	CYGB DNMT3B	1.90e-05	3	88	2	39227479
Pubmed	Molecular cloning of AMP deaminase isoform L. Sequence and bacterial expression of human AMPD2 cDNA.	AMPD2 AMPD3	1.90e-05	3	88	2	1429593
Pubmed	Diagnostic and prognostic role of SCCA-IgM serum levels in hepatocellular carcinoma (HCC).	SERPINB3 SERPINB4	1.90e-05	3	88	2	24635038
Pubmed	Heparin enhances serpin inhibition of the cysteine protease cathepsin L.	SERPINB3 SERPINB4	1.90e-05	3	88	2	19959474
Pubmed	Uteroglobin suppresses SCCA gene expression associated with allergic asthma.	SERPINB3 SERPINB4	1.90e-05	3	88	2	15677460
Pubmed	Association of self-DNA mediated TLR9-related gene, DNA methyltransferase, and cytokeratin protein expression alterations in HT29-cells to DNA fragment length and methylation status.	TLR9 DNMT3B	3.79e-05	4	88	2	24459426
Pubmed	Impact of viral and host DNA methylations on HPV16-related cervical cancer pathogenesis.	TLR9 DNMT3B	3.79e-05	4	88	2	28459195
Pubmed	Serpin squamous cell carcinoma antigen inhibits UV-induced apoptosis via suppression of c-JUN NH2-terminal kinase.	SERPINB3 SERPINB4	3.79e-05	4	88	2	16549498
Pubmed	Inhibitory mechanism of a cross-class serpin, the squamous cell carcinoma antigen 1.	SERPINB3 SERPINB4	3.79e-05	4	88	2	12949073
Pubmed	Squamous cell carcinoma antigen 1 promotes caspase-8-mediated apoptosis in response to endoplasmic reticulum stress while inhibiting necrosis induced by lysosomal injury.	SERPINB3 SERPINB4	3.79e-05	4	88	2	21576355
Pubmed	Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses.	IRAK4 TLR9	6.30e-05	5	88	2	16286015
Pubmed	A novel human NatA Nalpha-terminal acetyltransferase complex: hNaa16p-hNaa10p (hNat2-hArd1).	NAA11 NAA10	6.30e-05	5	88	2	19480662
Pubmed	Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase.	NAA11 NAA10	6.30e-05	5	88	2	16638120
Pubmed	Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage.	AMPD2 AMPD3	9.43e-05	6	88	2	29079593
Pubmed	Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II.	DICER1 DNMT3B	9.43e-05	6	88	2	18157120
Pubmed	αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells.	TLR9 ITGB5	1.75e-04	8	88	2	26965188
Pubmed	Inactivation of Dicer1 in Steroidogenic factor 1-positive cells reveals tissue-specific requirement for Dicer1 in adrenal, testis, and ovary.	NR5A1 DICER1	2.25e-04	9	88	2	20540774
Pubmed	A conserved acetylation switch enables pharmacological control of tubby-like protein stability.	AMPD2 NAA10 CUL7 DICER1 USP47	2.63e-04	223	88	5	33187986
Pubmed	Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4.	IRAK4 TLR9	2.81e-04	10	88	2	11923871
Pubmed	ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency.	DICER1 DNMT3B	2.81e-04	10	88	2	20569692
Pubmed	CpG DNA prevents liver injury and shock-mediated death by modulating expression of interleukin-1 receptor-associated kinases.	IRAK4 TLR9	2.81e-04	10	88	2	18378686
Pubmed	Comparative genomic analysis of the clade B serpin cluster at human chromosome 18q21: amplification within the mouse squamous cell carcinoma antigen gene locus.	SERPINB3 SERPINB4	3.43e-04	11	88	2	15203215
Pubmed	A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates.	NAA11 NAA10	4.11e-04	12	88	2	19660095
Pubmed	TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS.	IRAK4 TLR9	4.11e-04	12	88	2	26831104
Pubmed	Dicer deficiency reveals microRNAs predicted to control gene expression in the developing adrenal cortex.	NR5A1 DICER1	4.11e-04	12	88	2	23518926
Pubmed	Rescuing the aberrant sex development of H3K9 demethylase Jmjd1a-deficient mice by modulating H3K9 methylation balance.	NR5A1 USP9Y	4.11e-04	12	88	2	28949961
Pubmed	Polymorphisms in interleukin-1 receptor-associated kinase 4 are associated with total serum IgE.	IRAK4 TLR9	4.11e-04	12	88	2	19254290
Pubmed	Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins.	IRAK4 TLR9	4.85e-04	13	88	2	30108181
Pubmed	A targeted multienzyme mechanism for selective microtubule polyglutamylation.	TTLL12 TTLL4	4.85e-04	13	88	2	17499049
Pubmed	Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening.	IRAK4 TLR9	4.85e-04	13	88	2	12935356
Pubmed	Comparison of human chromosome 6p25 with mouse chromosome 13 reveals a greatly expanded ov-serpin gene repertoire in the mouse.	SERPINB3 SERPINB4	4.85e-04	13	88	2	11863365
Pubmed	Synaptic protein and pan-neuronal gene expression and their regulation by Dicer-dependent mechanisms differ between neurons and neuroendocrine cells.	NR5A1 DICER1	4.85e-04	13	88	2	23961995
Pubmed	Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1.	CDAN1 GANC	4.85e-04	13	88	2	12434312
Pubmed	Hereditary Spastic Paraplegia Overview	USP8 AMPD2 ATAD3A	5.57e-04	63	88	3	20301682
Pubmed	Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling.	IRAK4 TLR9	5.65e-04	14	88	2	14625308
Pubmed	Photocaged Cell-Permeable Ubiquitin Probe for Temporal Profiling of Deubiquitinating Enzymes.	USP8 ATAD3A USP47	5.83e-04	64	88	3	33141564
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	USP8 RAPGEF5 SYNE1 SELENOI VCPIP1 PDZD2	5.98e-04	407	88	6	12693553
Pubmed	Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells.	IRAK4 TLR9	6.51e-04	15	88	2	21045126
Pubmed	Deubiquitinating enzymes: a new class of biological regulators.	USP8 USP9Y	6.51e-04	15	88	2	9827704
Pubmed	Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo.	TLR9 ITGB5	6.51e-04	15	88	2	19576795
Pubmed	TET2 catalyzes active DNA demethylation of the Sry promoter and enhances its expression.	NR5A1 DNMT3B	6.51e-04	15	88	2	31530896
Pubmed	EHMT2 directs DNA methylation for efficient gene silencing in mouse embryos.	NAA11 DNMT3B	6.51e-04	15	88	2	26576615
Pubmed	The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer's disease.	SERPINB3 SERPINB4	6.51e-04	15	88	2	30704515
Pubmed	Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders.	USP8 AMPD2	6.51e-04	15	88	2	24482476
Pubmed	A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling.	IRAK4 TLR9	7.42e-04	16	88	2	16024789
Pubmed	A strategy for modulation of enzymes in the ubiquitin system.	USP8 USP9Y	8.40e-04	17	88	2	23287719
Pubmed	TMEM79/MATTRIN defines a pathway for Frizzled regulation and is required for Xenopus embryogenesis.	USP8 SENP5	9.43e-04	18	88	2	32924931
Pubmed	Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.	MYO5B ZBTB47 KCNS2	9.63e-04	76	88	3	10574461
Pubmed	Toll-like receptor signaling pathway variants and prostate cancer mortality.	IRAK4 TLR9	1.05e-03	19	88	2	19505919
Pubmed	Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.	ZNF814 ZNF681	1.17e-03	20	88	2	7479878
Pubmed	Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia.	ZNF814 ZNF681	1.17e-03	20	88	2	2542606
Pubmed	Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937.	ZNF460 ZNF267	1.29e-03	21	88	2	7865130
Pubmed	Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis.	KCTD13 VCPIP1	1.41e-03	22	88	2	22902628
Pubmed	Embryonic osteocalcin signaling determines lifelong adrenal steroidogenesis and homeostasis in the mouse.	GPRC6A NR5A1	1.41e-03	22	88	2	34905510
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	TTLL12 USP8 VSNL1 MTA3 SYNE1 ZBTB47 USP9Y ZNF251 USP47 VCPIP1	1.52e-03	1285	88	10	35914814
Pubmed	A genomic analysis of rat proteases and protease inhibitors.	SERPINB3 SERPINB4	1.55e-03	23	88	2	15060002
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MYO5B ATAD3A BAZ2B CPEB4 KCNS2 CUL7	1.60e-03	493	88	6	15368895
Pubmed	Isoform-specific GSK3A activity is negatively correlated with human sperm motility.	SERPINB4 TLR9 VCPIP1	1.67e-03	92	88	3	30824926
Pubmed	Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.	TAGAP CPEB4 ZNF831 BANK1 DNMT3B	1.80e-03	342	88	5	23128233
Pubmed	Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.	TAGAP IRAK4	1.83e-03	25	88	2	19898481
Pubmed	Lineage and stage specific requirement for Dicer1 in sympathetic ganglia and adrenal medulla formation and maintenance.	NR5A1 DICER1	1.83e-03	25	88	2	25661788
Interaction	FBLN5 interactions	ZNF430 ZNF492 ZNF460 PATZ1 ZNF253 CUL7 ZNF77 SENP5	3.62e-07	159	85	8	int:FBLN5
Interaction	LTBP2 interactions	ZNF430 ZNF708 ZNF480 ZNF251 ZNF77 SENP5	1.58e-06	85	85	6	int:LTBP2
Interaction	TRIM28 interactions	TTLL12 ZNF430 ZNF708 ZNF492 ZNF211 SLC25A12 KCTD13 ZNF718 ZNF460 ZNF253 ZNF485 ZNF267 ZNF816 ZNF480 CUL7 ZNF681 ZNF77 VCPIP1 DNMT3B	9.41e-06	1474	85	19	int:TRIM28
Interaction	TIMM50 interactions	ZNF430 ZNF708 RIN3 SLC25A12 ATAD3A ZNF253 ATG9A CUL7	1.45e-05	261	85	8	int:TIMM50
Interaction	ZNF460 interactions	ZNF430 ZNF211 ZNF460 PATZ1 ZNF267 ZNF251	2.59e-05	138	85	6	int:ZNF460
Interaction	FMOD interactions	SLC25A12 SERPINB3 SERPINB4 SENP5	3.52e-05	44	85	4	int:FMOD
Cytoband	19q13.41	ZNF816 ZNF534 ZNF480 ZNF880	1.61e-05	78	88	4	19q13.41
Cytoband	19p12	ZNF430 ZNF708 ZNF492 ZNF681	2.84e-05	90	88	4	19p12
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF430 ZNF708 ZNF492 ZNF681	9.31e-05	122	88	4	chr19p12
Cytoband	18q21.3	SERPINB3 SERPINB4	1.98e-04	11	88	2	18q21.3
Cytoband	15q15.2	CDAN1 GANC	4.28e-04	16	88	2	15q15.2
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZSCAN5B DPY19L3 ZNF211 ZNF460 ZNF816 ZNF814 ZNF534 ZNF480 ZNF880	4.74e-04	1192	88	9	chr19q13
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF430 ZNF708 ZBTB49 ZNF492 ZSCAN5B ZNF211 ZNF718 ZNF460 PATZ1 ZNF253 ZNF735 ZNF485 ZNF267 ZNF816 ZBTB47 ZNF814 ZNF534 ZNF479 ZNF480 ZNF880 ZNF860 ZNF251 ZNF681 ZNF77	4.69e-17	718	68	24	28
GeneFamily	Adenosine deaminase family	AMPD2 AMPD3	2.07e-04	6	68	2	1302
GeneFamily	N(alpha)-acetyltransferase subunits\|GCN5 related N-acetyltransferases	NAA11 NAA10	8.98e-04	12	68	2	660
GeneFamily	Ubiquitin specific peptidases	USP8 USP9Y USP47	1.22e-03	56	68	3	366
GeneFamily	Tubulin tyrosine ligase family	TTLL12 TTLL4	1.23e-03	14	68	2	779
GeneFamily	GCN5 related N-acetyltransferases	NAA11 NAA10	3.65e-03	24	68	2	1134
GeneFamily	Serpin peptidase inhibitors	SERPINB3 SERPINB4	8.53e-03	37	68	2	739
GeneFamily	EF-hand domain containing	VSNL1 SLC25A12 SPTA1 HPCAL4	9.32e-03	219	68	4	863
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|356C / Donor, Lineage, Cell class and subclass (all cells)	CDAN1 DOCK11 ZNF718 PATZ1 ZNF880 ZNF831	9.09e-07	166	87	6	c4f7ea1cad962b1d6ad77423d15978b68a0d6f1d
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CDAN1 DOCK11 ZNF718 PATZ1 ZNF880 ZNF831	1.12e-06	172	87	6	a9e13aa36087170dadca421ba9de588e5a1cf715
ToppCell	cellseq2-Epithelial-Epithelial_Airway\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CFAP47 CERKL VSNL1 NEK10 SERPINB4 DAW1	1.99e-06	190	87	6	17829f4de31b3d9e4d71ba4817d18842aa699773
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|390C / Donor, Lineage, Cell class and subclass (all cells)	TAGAP TTLL4 ZNF816 ZNF880 MCUB	9.06e-06	143	87	5	d877d914e4e74db2053baa310d318d6440e672bc
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	CDAN1 ZNF718 PATZ1 ZNF880 ZNF831	2.40e-05	175	87	5	f3a68aeb79c4935006e17a5ff3445a8ec0e33f5f
ToppCell	18-Distal-Epithelial-Multiciliated_precursor\|Distal / Age, Tissue, Lineage and Cell class	CFAP47 CERKL MYO5B DAW1 BBOF1	3.21e-05	186	87	5	58ab1360a1730655a5939295ba05997ac4a2d14e
ToppCell	Adult-Epithelial-ciliated_cell\|Adult / Lineage, Cell type, age group and donor	CFAP47 CERKL NEK10 DAW1 BBOF1	3.47e-05	189	87	5	b679920f0993e917dd86da082113bfbd85ea1ca5
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	VSNL1 DOCK11 RAPGEF5 CYGB PDZD2	3.74e-05	192	87	5	55f95454399fd533df75db06584eaa48d6ee3830
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	VSNL1 DOCK11 RAPGEF5 CYGB PDZD2	3.74e-05	192	87	5	5000440dc1ed17e7474d340921bdff945646f27e
ToppCell	NS-critical-d_07-13-Epithelial-Ciliated\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFAP47 CERKL NEK10 DAW1 BBOF1	3.93e-05	194	87	5	1ae8a10e508e672e6677f0e3c986ac30d05adeb3
ToppCell	PSB-critical-LOC-Epithelial-Ciliated\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFAP47 CERKL NEK10 SYNE1 BBOF1	4.22e-05	197	87	5	6865f4831eb23794fb88a8649d48d497bbae3f44
ToppCell	NS-moderate-d_0-4-Epithelial-Ciliated\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFAP47 CERKL NEK10 SYNE1 BBOF1	4.22e-05	197	87	5	71fea4aa6ce96c7693fa94792d08770622873850
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_ciliated-Ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CFAP47 CERKL NEK10 DAW1 BBOF1	4.54e-05	200	87	5	926a7ea94b5908aebf103893ea83ce9d25285b65
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CFAP47 CERKL NEK10 DAW1 BBOF1	4.54e-05	200	87	5	06ce6e03498ba38ef6a06eaf2731e3b2eeda59eb
Drug	NSC623156	AMPD2 AMPD3 PRIM1	1.03e-06	6	86	3	CID000360780
Disease	Ogden syndrome (implicated_via_orthology)	NAA11 NAA10	7.82e-06	2	83	2	DOID:0050781 (implicated_via_orthology)
Disease	pontocerebellar hypoplasia (implicated_via_orthology)	AMPD2 AMPD3	7.77e-05	5	83	2	DOID:0060264 (implicated_via_orthology)
Disease	phospholipids:total lipids ratio, intermediate density lipoprotein measurement	AMPD3 MCUB BANK1	9.03e-04	67	83	3	EFO_0008595, EFO_0020946
Disease	blood aluminium measurement	BAZ2B NAA11	1.44e-03	20	83	2	EFO_0007575
Disease	blood pressure	SYNE1 BANK1	1.74e-03	22	83	2	EFO_0004325
Disease	primary biliary cholangitis (is_marker_for)	CPEB4 TLR9	2.25e-03	25	83	2	DOID:12236 (is_marker_for)
Disease	mean arterial pressure, alcohol drinking	NEK10 ZNF831 BANK1	2.69e-03	98	83	3	EFO_0004329, EFO_0006340

Protein segments in the cluster

Peptide	Gene	Start	Entry
NKFYNVHFSNKLPAR	BANK1	756	Q8NDB2
VKLLHNRSNNKYSYT	KCTD13	171	Q8WZ19
QHKCFTSYRFKSLKQ	ACSM6	326	Q6P461
HFNLATFNKLVSYRK	DNMT3B	286	Q9UBC3
KQQSQYRRKLFDASH	BAZ2B	1356	Q9UIF8
LNAFLYRTGQHSNKF	ATAD3A	481	Q9NVI7
SKYAFARTVNKLNHA	EXOC1L	106	A0A1B0GW35
VFQNKTFHVYKLSRN	DPY19L3	701	Q6ZPD9
RNTFHRFDKFNAKYN	AMPD2	481	Q01433
RFKNKAYLLQAFTHA	DICER1	1676	Q9UPY3
ISRKHYKQIAQAAFN	BBOF1	376	Q8ND07
ANFSSDRAFHTFKKQ	CDAN1	441	Q8IWY9
QTFHRFDKFNSKYNP	AMPD3	381	Q01432
ASKFAQHAFRTFDKN	HPCAL4	61	Q9UM19
YSAVKSRQFLQFFHK	MCUB	276	Q9NWR8
YQTSNRFHFKITDFN	MGAM2	131	Q2M2H8
KEYTSNVFLQGKRFH	MGME1	166	Q9BQP7
QYKSHFVAASLSNQK	DDX42	706	Q86XP3
NFSINYKNERNFSKH	NEK10	86	Q6ZWH5
KHFTVNKNFLSNYSR	PDZD2	1511	O15018
NFNAKYVSLHVRKSN	NAA10	101	P41227
TLNRYSNFYNKSQSH	CUL7	1421	Q14999
FQYLHQKQFLHRKFS	GANC	821	Q8TET4
NKFSHFYRRQKQLES	KCNS2	411	Q9ULS6
QNSNHTFYLFKVLKA	DAW1	76	Q8N136
HTVDFTFNKFNKSYN	ITGB5	781	P18084
IFNHSQRTLAYKANK	GPRC6A	376	Q5T6X5
FSRTFNDHKQKYLQL	GOLIM4	146	O00461
GSFFRSKSYLNKHIQ	PATZ1	611	Q9HBE1
IKNYFQHREFSFTLK	PRIM1	36	P49642
NNFEYTKRKTFLRTH	DOCK11	1511	Q5JSL3
FFSRVYNLHQKNGFT	ATG9A	46	Q7Z3C6
VNFPSAKQYFSQFKH	CYGB	51	Q8WWM9
HLKRYASVKNQFNFP	CERKL	471	Q49MI3
NFFRSYKNNTLKLNS	SELENOI	241	Q9C0D9
KNFASNHIQLQKYAR	CPEB4	336	Q17RY0
HSFSFYELKNVTNNF	IRAK4	166	Q9NWZ3
FFGSSKIKHARVYNN	CFAP47	261	Q6ZTR5
FHAFLSNNRKLYKKV	RIN3	591	Q8TB24
HTTYFTKFARQVCKN	MTA3	471	Q9BTC8
FLSNHINSYFKRKEK	PNPLA8	206	Q9NP80
FFKRTVQNNKHYTCT	NR5A1	36	Q13285
KRNFFSRHQSFTTKT	TAGAP	481	Q8N103
ESNLQDKYQSFKHFR	SYNE1	341	Q8NF91
YSPQKKNKALFHQFS	RAPGEF5	211	Q92565
NFKNVNFTTIQRKYF	MSH4	231	O15457
FQQFRKSKENNIFYS	SERPINB3	16	P29508
RKKHLNYTEFTQFLQ	SLC25A12	141	O75746
IRKQSVNYFKNYHRT	VPS50	441	Q96JG6
FNSFFHRQLVTKGYN	SENP5	606	Q96HI0
VFHKFSNSNKDKIRY	ZNF718	151	Q3SXZ3
SSVKSHILNKYRNDF	ZNF880	151	Q6PDB4
KAFSHAQYFQKHVRS	ZNF77	471	Q15935
GKAFTYRSNFVLHNK	ZNF460	286	Q14592
FSKFSNSNRHNARYT	ZNF735	166	P0CB33
ASKFAQHAFRTFDKN	VSNL1	61	P62760
NFNAKYVSLHVRKSN	NAA11	101	Q9BSU3
LSFNYQKRVSFAHLS	TLR9	341	Q9NR96
NFDQYRKVFTHSSLL	ZNF267	161	Q14586
NKSFKYFSQLSIHRR	ZSCAN5B	361	A6NJL1
LSSHFKVFRVYASNQ	USP47	1076	Q96K76
FKYRSNFTKHQKTHS	ZNF840P	426	A6NDX5
KSFSQNFSLIYHQRV	ZNF211	376	Q13398
FSVKTHIFNNYRNDF	ZNF534	166	Q76KX8
FQQFRKSKENNIFYS	SERPINB4	16	P48594
ATNIQRKYLKHQTFA	SPTA1	1531	P02549
FDTIQRSKNHYQKRA	USP9Y	2371	O00507
KSTHGQLRTDKNYSF	VCPIP1	496	Q96JH7
FNFSHFKDYRKLSQE	TTLL12	336	Q14166
AAYSQFFHSLFTQNK	ZBTB47	36	Q9UFB7
NSNRDKTRYTGNKHF	ZNF479	171	Q96JC4
KTFNYNKAQSHQLFA	TRPM1	316	Q7Z4N2
KVFSYNSNFARHQRI	ZNF480	266	Q8WV37
TFNYSSNFTNHKKIH	ZNF708	456	P17019
FYKFSNPNIQKIRHT	ZNF430	186	Q9H8G1
DKYVKVFHKFSNSNR	ZNF492	116	Q9P255
KVFHKFSNSNTYKTR	ZNF253	151	O75346
KTFKYNSDLSRHQRS	ZNF251	216	Q9BRH9
DFENTSKFSKHKRNY	ZNF681	626	Q96N22
FKAHKNVLAAFSQYF	ZBTB49	36	Q6ZSB9
NYENNFFHSSLLTLK	ZNF860	206	A6NHJ4
FKTQSNLYKHRRTQT	ZNF831	181	Q5JPB2
TQHYSIGLRQKNSFK	TTLL4	6	Q14679
GKVFKYNSSFISHQR	ZNF485	136	Q8NCK3
NNLKKYNLFSVSNHY	USP8	1046	P40818
KSFSKYVSFSNHQRV	ZNF814	276	B7Z6K7
KSFSKYASFSNHQRV	ZNF814	331	B7Z6K7
GKSFSKYASFSNHQR	ZNF814	386	B7Z6K7
KYGKNFLHSSFTQIQ	ZNF816	206	Q0VGE8
QKLYDRHSSSQHFQK	MYO5B	526	Q9ULV0