Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	cornified envelope	DSP RPTN PKP4	1.91e-04	69	34	3	GO:0001533
Domain	EPHD	MLLT10 TCF20	6.03e-04	22	31	2	PS51805
Domain	fn3	NEO1 PTPRH EPHB1	2.41e-03	162	31	3	PF00041
Domain	FN3	NEO1 PTPRH EPHB1	3.50e-03	185	31	3	SM00060
Domain	FN3	NEO1 PTPRH EPHB1	4.30e-03	199	31	3	PS50853
Domain	FN3_dom	NEO1 PTPRH EPHB1	4.93e-03	209	31	3	IPR003961
Domain	PHD	MLLT10 TCF20	9.54e-03	89	31	2	SM00249
Domain	ARM-like	PPP2R5A NIPBL PKP4	9.96e-03	270	31	3	IPR011989
Domain	Znf_PHD	MLLT10 TCF20	9.96e-03	91	31	2	IPR001965
Domain	ZF_PHD_2	MLLT10 TCF20	1.08e-02	95	31	2	PS50016
Domain	ZF_PHD_1	MLLT10 TCF20	1.10e-02	96	31	2	PS01359
Pubmed	Replication of a genome-wide case-control study of esophageal squamous cell carcinoma.	TMC5 PKP4 EPHB1	2.46e-06	27	34	3	18649358
Pubmed	The Armadillo family protein p0071 is a VE-cadherin- and desmoplakin-binding protein.	DSP PKP4	5.56e-06	4	34	2	12426320
Pubmed	Characterization of the DOT1L network: implications of diverse roles for DOT1L.	MLLT10 ACACA NIPBL	8.87e-06	41	34	3	20431927
Pubmed	Combining Homologous Recombination and Phosphopeptide-binding Data to Predict the Impact of BRCA1 BRCT Variants on Cancer Risk.	BRIP1 ACACA	9.26e-06	5	34	2	30257991
Pubmed	Targeting of p0071 to desmosomes and adherens junctions is mediated by different protein domains.	DSP PKP4	9.26e-06	5	34	2	12615965
Pubmed	Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation.	NCOA1 BCL3	1.39e-05	6	34	2	10497212
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	GOLIM4 SENP2 IGBP1 PPP2R5A PTPRH DSP PKP4	5.87e-05	1049	34	7	27880917
Pubmed	Assessment of splice variant-specific functions of desmocollin 1 in the skin.	DSP RPTN	7.19e-05	13	34	2	14673151
Pubmed	Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis.	NEO1 FTH1	7.19e-05	13	34	2	20065295
Pubmed	Defects in Stratum Corneum Desquamation Are the Predominant Effect of Impaired ABCA12 Function in a Novel Mouse Model of Harlequin Ichthyosis.	DSP RPTN	8.38e-05	14	34	2	27551807
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	BRIP1 TCF20 ACACA DSP NIPBL FTH1	9.41e-05	774	34	6	15302935
Pubmed	Long noncoding RNA PiHL regulates p53 protein stability through GRWD1/RPL11/MDM2 axis in colorectal cancer.	NAV3 GJA10	9.66e-05	15	34	2	31903119
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	IGBP1 NEO1 BCL3 DSP FTH1	1.15e-04	497	34	5	23414517
Pubmed	A systematic study of nuclear interactome of C-terminal domain small phosphatase-like 2 using inducible expression system and shotgun proteomics.	DSP NIPBL	1.41e-04	18	34	2	26674342
Pubmed	Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism.	PFKFB2 ACACA	2.53e-04	24	34	2	25505152
Pubmed	Synergistic integration of Netrin and ephrin axon guidance signals by spinal motor neurons.	NEO1 EPHB1	2.53e-04	24	34	2	26633881
Pubmed	Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18.	DSP RPTN	2.74e-04	25	34	2	23132931
Pubmed	Genomic architecture of Shh-dependent cochlear morphogenesis.	BRIP1 DSP	3.45e-04	28	34	2	31488567
Pubmed	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	ATP9B TCF20 ACACA	4.43e-04	152	34	3	34299191
Pubmed	GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.	MLLT10 ACACA	4.52e-04	32	34	2	23535730
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	TCF20 ACACA PKP4	7.25e-04	180	34	3	35198878
Pubmed	A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein.	IGBP1 PPP2R5A	9.35e-04	46	34	2	18782753
Pubmed	Ephrin-As, Eph receptors and integrin α3 interact and colocalise at membrane protrusions of U251MG glioblastoma cells.	ACACA DSP PKP4	9.41e-04	197	34	3	23686814
Interaction	TLE3 interactions	MASTL NCOA1 IGBP1 BRIP1 MLLT10 TCF20 NIPBL	2.59e-06	376	34	7	int:TLE3
Cytoband	Ensembl 112 genes in cytogenetic band chr10p12	MASTL MLLT10	4.86e-03	140	34	2	chr10p12
Cytoband	Ensembl 112 genes in cytogenetic band chr12q21	NAV3 BBS10	4.93e-03	141	34	2	chr12q21
GeneFamily	Fibronectin type III domain containing	NEO1 PTPRH EPHB1	8.05e-04	160	21	3	555
Coexpression	PHONG_TNF_RESPONSE_VIA_P38_COMPLETE	NAV3 NEO1 BCL3 TCF20 ACACA	9.91e-06	224	34	5	M2500
Coexpression	VERRECCHIA_RESPONSE_TO_TGFB1_C6	NEO1 DSP	1.63e-05	5	34	2	M15374
Coexpression	GSE37532_VISCERAL_ADIPOSE_TISSUE_VS_LN_DERIVED_PPARG_KO_TREG_CD4_TCELL_UP	IGBP1 TEX15 DHX58 BBS10	7.45e-05	174	34	4	M8947
Coexpression	GSE27291_6H_VS_7D_STIM_GAMMADELTA_TCELL_DN	GOLIM4 SENP2 FTH1 CCSER1	9.84e-05	187	34	4	M8460
Coexpression	GSE18791_CTRL_VS_NEWCASTLE_VIRUS_DC_18H_DN	MASTL BRIP1 DHX58 DSP	1.11e-04	193	34	4	M4284
Coexpression	GSE18791_CTRL_VS_NEWCASTLE_VIRUS_DC_8H_DN	MASTL BRIP1 BCL3 DHX58	1.18e-04	196	34	4	M4267
Coexpression	GSE18791_CTRL_VS_NEWCASTLE_VIRUS_DC_6H_DN	MASTL BRIP1 BCL3 DHX58	1.23e-04	198	34	4	M4264
Coexpression	GSE20727_H2O2_VS_ROS_INHIBITOR_TREATED_DC_DN	CCDC66 PFKFB2 TCF20 NIPBL	1.25e-04	199	34	4	M9253
Coexpression	GSE40274_FOXP3_VS_FOXP3_AND_GATA1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN	TEX15 BCL3 DHX58 PKP4	1.25e-04	199	34	4	M9180
Coexpression	GSE17721_CTRL_VS_CPG_6H_BMDC_DN	IGBP1 PPP2R5A DHX58 PKP4	1.28e-04	200	34	4	M3765
Coexpression	YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_6	IGBP1 PPP2R5A DSP	1.47e-04	79	34	3	M13387
Coexpression	LAKE_ADULT_KIDNEY_C14_DISTAL_CONVOLUTED_TUBULE	NCOA1 ATP9B PKP4 CCSER1	1.48e-04	208	34	4	M39233
Coexpression	MURARO_PANCREAS_BETA_CELL	IGBP1 NEO1 PFKFB2 DSP SHISAL1 UNC80 FTH1	1.79e-04	946	34	7	M39169
Coexpression	GUO_TARGETS_OF_IRS1_AND_IRS2	BCL3 ACACA NIPBL	2.71e-04	97	34	3	MM1318
Coexpression	GUO_TARGETS_OF_IRS1_AND_IRS2	BCL3 ACACA NIPBL	2.71e-04	97	34	3	M2434
Coexpression	NAKAYA_PBMC_FLUAD_IMUVAC_MALE_AGE_14_27YO_CORRELATED_WITH_HAI_RESPONSE_MF59_ADJUVANTED_AND_NON_1DY_GENES_IN_BTM_M75_POSITIVE	BCL3 DHX58	2.75e-04	19	34	2	M41012
Coexpression	CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3	PFKFB2 FAM199X TMC5 ACACA PTPRH FTH1	3.07e-04	726	34	6	M4210
Coexpression	YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_6	IGBP1 PPP2R5A DSP	3.14e-04	102	34	3	MM872
ToppCell	COVID-19-Epithelial_cells-Airway_club\|COVID-19 / group, cell type (main and fine annotations)	TMC5 ACACA DSP CCSER1	1.17e-05	185	34	4	cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCOA1 PFKFB2 UNC80 PKP4	1.24e-05	188	34	4	a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCOA1 PFKFB2 UNC80 PKP4	1.32e-05	191	34	4	3387b95a3f2445c672d407922fdce3a91eabaef8
ToppCell	Bronchial-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CDKL5 TMC5 ACACA CCSER1	1.55e-05	199	34	4	5f7da3eab58ace6cddb3179a415cd839d5767958
ToppCell	Parenchymal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CDKL5 TMC5 ACACA CCSER1	1.55e-05	199	34	4	5cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCell	Tracheal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TMC5 ACACA PKP4 CCSER1	1.58e-05	200	34	4	d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
Drug	Ketoconazole [65277-42-1]; Up 200; 7.6uM; HL60; HT_HG-U133A	ATP9B MLLT10 ACACA PKP4 FTH1	8.56e-06	189	34	5	1285_UP
Drug	Nifenazone [2139-47-1]; Down 200; 13uM; PC3; HT_HG-U133A	NAV3 BRIP1 MLLT10 SHISAL1 PKP4	9.95e-06	195	34	5	2122_DN
Drug	felodipine; Down 200; 10uM; MCF7; HT_HG-U133A_EA	GOLIM4 IGBP1 MLLT10 ACACA NIPBL	1.02e-05	196	34	5	848_DN
Disease	esophageal adenocarcinoma, digestive system disease, Barrett's esophagus	GOLIM4 BCL3	1.84e-04	18	33	2	EFO_0000280, EFO_0000405, EFO_0000478
Disease	cytotoxicity measurement, response to metformin	GOLIM4 CCSER1	2.51e-04	21	33	2	EFO_0006952, GO_1901558
Disease	thrombocytopenia (is_implicated_in)	MASTL BRIP1	4.18e-04	27	33	2	DOID:1588 (is_implicated_in)
Disease	creatinine measurement	CDKL5 SENP2 ATP9B BRIP1 PFKFB2 UNC80	7.35e-04	995	33	6	EFO_0004518
Disease	lysophosphatidylethanolamine measurement	PTPRH FTH1	9.68e-04	41	33	2	EFO_0010225
Disease	neuroimaging measurement	NAV3 NEO1 PFKFB2 MLLT10 TMC5 FTH1	1.07e-03	1069	33	6	EFO_0004346
Disease	methadone dose measurement	TEX15 CCSER1	2.20e-03	62	33	2	EFO_0007907
Disease	breast carcinoma (is_marker_for)	NCOA1 BRIP1	2.49e-03	66	33	2	DOID:3459 (is_marker_for)
Disease	fasting blood glucose measurement	ATP9B DHX58 CCSER1	4.00e-03	287	33	3	EFO_0004465
Disease	alanine measurement	PFKFB2 CCSER1	4.18e-03	86	33	2	EFO_0009765

Protein segments in the cluster

Peptide	Gene	Start	Entry
GNSRSSTQMNSYSDS	PKP4	141	Q99569
MSGASSSEQNNNSYE	PFKFB2	1	O60825
QQSDHSSFGLQNTMS	GJA10	351	Q969M2
MDTDTSQLGFHQSNQ	MASTL	411	Q96GX5
TLNRMSFSSNLNHYG	ACACA	1196	Q13085
NFGHNDSTSQMSLNS	CCSER1	286	Q9C0I3
NYMTQTNDQNGTSSL	BBS10	431	Q8TAM1
HNEFNSSMARSQTNT	EPHB1	476	P54762
HVRDSYSQMQSQAGG	ATP9B	501	O43861
GNSASNSSANMSRAH	FAM199X	301	Q6PEV8
NNSAENHTANSSMAY	IGBP1	131	P78318
MQSSLAARYATQSNH	NAV3	221	Q8IVL0
NSMHSSPASSNYQQT	NIPBL	131	Q6KC79
TNNDMNQGTSRHFNY	BRIP1	96	Q9BX63
DSNSRYSALNVQHQM	GOLIM4	106	O00461
MTTASTSQVRQNYHQ	FTH1	1	P02794
YCQTGTMSRHQNQNT	DSP	56	P15924
MEYNASNISNSRHDS	CCDC66	576	A2RUB6
AGNSSQSTHMTQRDQ	DHX58	406	Q96C10
NVNAQMYSGSSALHS	BCL3	301	P20749
SNSRSQQNRHSFMES	CDKL5	436	O76039
TSNYHSSQRSQMDTL	SENP2	236	Q9HC62
MTSSACNNNNRSYSN	NCOA1	521	Q15788
DNSMDSNIHQRRNSY	NEO1	1201	Q92859
QANLTASSEGYMHNN	SHISAL1	81	Q3SXP7
NSAYNMHSILSNTSA	PPP2R5A	471	Q15172
SQAPSHMYGNRSNSS	MLLT10	636	P55197
NHTMSSGVNTRYQEQ	UNC80	2441	Q8N2C7
NRSSYVTQHQRMHTG	ZNF519	386	Q8TB69
MQSFREQSSYHGNQQ	TCF20	1	Q9UGU0
STIQHGNSGASYNMQ	TMC5	511	Q6UXY8
SSDHFSGQQENLNSM	TEX15	2421	Q9BXT5
TERQGQSSHYSQMDR	RPTN	406	Q6XPR3
QSSHYSQMDRQGQGS	RPTN	411	Q6XPR3
QSSHYSQMDRQGQSS	RPTN	531	Q6XPR3
SQMDRQGQSSHYGQT	RPTN	536	Q6XPR3
GHSQSQMVASASENN	PTPRH	831	Q9HD43