Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF562 ZNF473 OVOL3 ZNF658 ZNF423 ZNF689 YY2 ZNF343 ZNF225 PPARG ZNF658B ZNF865 ZKSCAN5 ZNF835 ZNF248 ZNF20 ZKSCAN3 ZNF566 ZNF616 ZNF264 PRDM14 ZNF548	6.83e-06	1459	106	22	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF562 ZNF473 OVOL3 ZNF658 ZNF423 ZNF689 YY2 ZNF343 ZNF225 PPARG ZNF658B ZKSCAN5 ZNF248 ZNF20 ZKSCAN3 ZNF566 ZNF616 ZNF264 ZNF548 NOTCH2	4.70e-05	1412	106	20	GO:0000981
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF562 ZNF473 OVOL3 ZNF658 ZNF423 ZNF689 YY2 ZNF225 PPARG ZNF658B ZNF865 ZKSCAN5 ZNF835 ZKSCAN3 ZNF616 ZNF264 ZNF548 NOTCH2	1.19e-04	1271	106	18	GO:0000987
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF562 ZNF473 OVOL3 ZNF658 ZNF423 ZNF689 YY2 ZNF225 PPARG ZNF658B ZNF865 ZKSCAN5 ZNF835 ZKSCAN3 ZNF616 ZNF264 ZNF548	2.87e-04	1244	106	17	GO:0000978
GeneOntologyMolecularFunction	extracellular matrix structural constituent	LAMA5 PAPLN CRELD1 LTBP4 AGRN FBN3	5.03e-04	188	106	6	GO:0005201
GeneOntologyMolecularFunction	calcium ion binding	CAPN12 PCDHA2 ADAM8 CRELD1 SLIT3 LRP2 LTBP4 CDH3 AGRN FBN3 NOTCH2 CDH18	6.20e-04	749	106	12	GO:0005509
GeneOntologyMolecularFunction	histone H3K4 monomethyltransferase activity	KMT2C KMT2A	7.66e-04	8	106	2	GO:0140945
Domain	Znf_C2H2	ZNF562 ZNF473 OVOL3 ZNF658 ZNF423 ZNF689 YY2 ZNF343 ZNF225 RNF114 CHAMP1 ZNF865 ZKSCAN5 ZNF835 ZNF248 ZNF106 ZNF20 ZKSCAN3 ZNF566 ADAMTS17 ZNF616 ZNF264 ZNF598 PRDM14 ZNF548 ZNF653	2.49e-13	805	105	26	IPR007087
Domain	Znf_C2H2-like	ZNF562 ZNF473 OVOL3 ZNF658 ZNF423 ZNF689 YY2 ZNF343 ZNF225 RNF114 CHAMP1 ZNF865 ZKSCAN5 ZNF835 ZNF248 ZNF106 ZNF20 ZKSCAN3 ZNF566 ZNF616 ZNF264 ZNF598 PRDM14 ZNF548 ZNF653	1.45e-12	796	105	25	IPR015880
Domain	ZnF_C2H2	ZNF562 ZNF473 OVOL3 ZNF658 ZNF423 ZNF689 YY2 ZNF343 ZNF225 RNF114 CHAMP1 ZNF865 ZKSCAN5 ZNF835 ZNF248 ZNF106 ZNF20 ZKSCAN3 ZNF566 ZNF616 ZNF264 ZNF598 PRDM14 ZNF548 ZNF653	2.02e-12	808	105	25	SM00355
Domain	ZINC_FINGER_C2H2_2	ZNF562 ZNF473 OVOL3 ZNF658 ZNF423 ZNF689 YY2 ZNF343 ZNF225 CHAMP1 ZNF865 ZKSCAN5 ZNF835 ZNF248 ZNF106 ZNF20 ZKSCAN3 ZNF566 ZNF616 ZNF264 ZNF598 PRDM14 ZNF548 ZNF653	5.95e-12	775	105	24	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF562 ZNF473 OVOL3 ZNF658 ZNF423 ZNF689 YY2 ZNF343 ZNF225 CHAMP1 ZNF865 ZKSCAN5 ZNF835 ZNF248 ZNF106 ZNF20 ZKSCAN3 ZNF566 ZNF616 ZNF264 ZNF598 PRDM14 ZNF548 ZNF653	6.28e-12	777	105	24	PS00028
Domain	Znf_C2H2/integrase_DNA-bd	ZNF562 ZNF473 OVOL3 ZNF658 ZNF423 ZNF689 YY2 ZNF343 ZNF225 CHAMP1 ZNF865 ZKSCAN5 ZNF835 ZNF248 ZNF20 ZKSCAN3 ZNF566 ZNF616 ZNF264 PRDM14 ZNF548 ZNF653	3.35e-11	694	105	22	IPR013087
Domain	-	ZNF562 ZNF473 ZNF658 ZNF423 ZNF689 YY2 ZNF343 ZNF225 CHAMP1 ZNF865 ZKSCAN5 ZNF835 ZNF248 ZNF20 ZKSCAN3 ZNF566 ZNF616 ZNF264 PRDM14 ZNF548 ZNF653	1.58e-10	679	105	21	3.30.160.60
Domain	zf-C2H2	ZNF562 ZNF473 ZNF658 ZNF423 ZNF689 ZNF343 ZNF225 CHAMP1 ZNF865 ZKSCAN5 ZNF835 ZNF248 ZNF106 ZNF20 ZKSCAN3 ZNF566 ZNF616 ZNF264 PRDM14 ZNF548 ZNF653	2.29e-10	693	105	21	PF00096
Domain	KRAB	ZNF562 ZNF473 ZNF658 ZNF689 ZNF343 ZNF225 ZKSCAN5 ZNF248 ZNF20 ZKSCAN3 ZNF566 ZNF616 ZNF264 ZNF548	1.33e-08	358	105	14	PS50805
Domain	KRAB	ZNF562 ZNF473 ZNF658 ZNF689 ZNF343 ZNF225 ZKSCAN5 ZNF248 ZNF20 ZKSCAN3 ZNF566 ZNF616 ZNF264 ZNF548	1.33e-08	358	105	14	PF01352
Domain	KRAB	ZNF562 ZNF473 ZNF658 ZNF689 ZNF343 ZNF225 ZKSCAN5 ZNF248 ZNF20 ZKSCAN3 ZNF566 ZNF616 ZNF264 ZNF548	1.95e-08	369	105	14	SM00349
Domain	KRAB	ZNF562 ZNF473 ZNF658 ZNF689 ZNF343 ZNF225 ZKSCAN5 ZNF248 ZNF20 ZKSCAN3 ZNF566 ZNF616 ZNF264 ZNF548	2.02e-08	370	105	14	IPR001909
Domain	EGF_1	LAMA5 TEK ADAM8 CRELD1 MALRD1 SLIT3 LRP2 USH2A LTBP4 AGRN FBN3 NOTCH2	2.06e-08	255	105	12	PS00022
Domain	EGF	LAMA5 TEK ADAM8 CRELD1 MALRD1 SLIT3 LRP2 LTBP4 AGRN FBN3 NOTCH2	8.73e-08	235	105	11	SM00181
Domain	EGF-like_dom	LAMA5 TEK ADAM8 CRELD1 MALRD1 SLIT3 LRP2 LTBP4 AGRN FBN3 NOTCH2	1.57e-07	249	105	11	IPR000742
Domain	Growth_fac_rcpt_	LAMA5 TEK CRELD1 SLIT3 LRP2 LTBP4 RSPO1 FBN3 NOTCH2	2.38e-07	156	105	9	IPR009030
Domain	EGF-like_CS	LAMA5 TEK ADAM8 CRELD1 MALRD1 SLIT3 LRP2 LTBP4 AGRN FBN3 NOTCH2	2.51e-07	261	105	11	IPR013032
Domain	EGF_2	LAMA5 TEK ADAM8 CRELD1 MALRD1 SLIT3 LRP2 LTBP4 AGRN FBN3 NOTCH2	2.93e-07	265	105	11	PS01186
Domain	EGF_3	TEK ADAM8 CRELD1 MALRD1 SLIT3 LRP2 LTBP4 AGRN FBN3 NOTCH2	8.34e-07	235	105	10	PS50026
Domain	zf-C2H2_6	ZNF562 ZNF473 ZNF658 ZNF423 ZNF225 ZNF865 ZKSCAN5 ZNF20 ZNF566 ZNF616 ZNF548	1.56e-06	314	105	11	PF13912
Domain	EGF_CA	CRELD1 SLIT3 LRP2 LTBP4 AGRN FBN3 NOTCH2	5.72e-06	122	105	7	SM00179
Domain	EGF-like_Ca-bd_dom	CRELD1 SLIT3 LRP2 LTBP4 AGRN FBN3 NOTCH2	6.37e-06	124	105	7	IPR001881
Domain	Znf_RING/FYVE/PHD	TRAF2 ZNF423 TRAIP KMT2E RNF114 WDR59 PHF21A KMT2C TRAF4 KMT2A TRIM13 ZNF598	1.04e-05	459	105	12	IPR013083
Domain	AT_hook	PHF21A KMT2C KMT2A ZNF653	1.50e-05	27	105	4	SM00384
Domain	AT_hook_DNA-bd_motif	PHF21A KMT2C KMT2A ZNF653	1.50e-05	27	105	4	IPR017956
Domain	EGF_Ca-bd_CS	CRELD1 SLIT3 LRP2 LTBP4 FBN3 NOTCH2	1.79e-05	97	105	6	IPR018097
Domain	EGF_CA	CRELD1 SLIT3 LRP2 LTBP4 FBN3 NOTCH2	2.01e-05	99	105	6	PS01187
Domain	EGF-type_Asp/Asn_hydroxyl_site	CRELD1 SLIT3 LRP2 LTBP4 FBN3 NOTCH2	2.96e-05	106	105	6	IPR000152
Domain	Laminin_EGF	LAMA5 CRELD1 USH2A AGRN	4.32e-05	35	105	4	PF00053
Domain	-	TRAF2 ZNF423 TRAIP KMT2E RNF114 PHF21A KMT2C TRAF4 KMT2A TRIM13 ZNF598	4.49e-05	449	105	11	3.30.40.10
Domain	LAM_G_DOMAIN	LAMA5 SLIT3 USH2A AGRN	6.01e-05	38	105	4	PS50025
Domain	Laminin_EGF	LAMA5 CRELD1 USH2A AGRN	6.01e-05	38	105	4	IPR002049
Domain	EGF	MALRD1 SLIT3 LRP2 AGRN FBN3 NOTCH2	7.80e-05	126	105	6	PF00008
Domain	SET	KMT2E KMT2C KMT2A PRDM14	8.14e-05	41	105	4	PF00856
Domain	AT_hook	PHF21A KMT2C KMT2A	9.17e-05	16	105	3	PF02178
Domain	LamG	LAMA5 SLIT3 USH2A AGRN	1.08e-04	44	105	4	SM00282
Domain	EGF_CA	CRELD1 LRP2 LTBP4 FBN3 NOTCH2	1.24e-04	86	105	5	PF07645
Domain	SET	KMT2E KMT2C KMT2A PRDM14	1.28e-04	46	105	4	SM00317
Domain	SET_dom	KMT2E KMT2C KMT2A PRDM14	1.78e-04	50	105	4	IPR001214
Domain	SET	KMT2E KMT2C KMT2A PRDM14	1.78e-04	50	105	4	PS50280
Domain	ASX_HYDROXYL	CRELD1 LRP2 LTBP4 FBN3 NOTCH2	2.52e-04	100	105	5	PS00010
Domain	FYrich_C	KMT2C KMT2A	3.10e-04	5	105	2	IPR003889
Domain	FYrich_N	KMT2C KMT2A	3.10e-04	5	105	2	IPR003888
Domain	FYRC	KMT2C KMT2A	3.10e-04	5	105	2	SM00542
Domain	FYRN	KMT2C KMT2A	3.10e-04	5	105	2	SM00541
Domain	FYRN	KMT2C KMT2A	3.10e-04	5	105	2	PF05964
Domain	FYRC	KMT2C KMT2A	3.10e-04	5	105	2	PF05965
Domain	FYRC	KMT2C KMT2A	3.10e-04	5	105	2	PS51543
Domain	FYRN	KMT2C KMT2A	3.10e-04	5	105	2	PS51542
Domain	Laminin_G	LAMA5 SLIT3 USH2A AGRN	3.17e-04	58	105	4	IPR001791
Domain	RING	TRAF2 TRAIP RNF114 PHF21A KMT2C TRAF4 TRIM13 ZNF598	3.27e-04	305	105	8	SM00184
Domain	TNF_rcpt--assoc_TRAF	TRAF2 TRAF4	4.63e-04	6	105	2	IPR012227
Domain	Znf_RING	TRAF2 TRAIP RNF114 PHF21A KMT2C TRAF4 TRIM13 ZNF598	5.08e-04	326	105	8	IPR001841
Domain	EGF_LAM_2	LAMA5 USH2A AGRN	6.28e-04	30	105	3	PS50027
Domain	EGF_LAM_1	LAMA5 USH2A AGRN	6.28e-04	30	105	3	PS01248
Domain	TB	LTBP4 FBN3	6.45e-04	7	105	2	PF00683
Domain	HMGI/Y_DNA-bd_CS	PHF21A KMT2C ZNF653	6.92e-04	31	105	3	IPR000637
Domain	PHD	KMT2E PHF21A KMT2C KMT2A	8.44e-04	75	105	4	PF00628
Domain	-	LTBP4 FBN3	8.57e-04	8	105	2	3.90.290.10
Domain	zf-TRAF	TRAF2 TRAF4	8.57e-04	8	105	2	PF02176
Domain	EGF_Lam	LAMA5 USH2A AGRN	9.91e-04	35	105	3	SM00180
Domain	Znf_PHD-finger	KMT2E PHF21A KMT2C KMT2A	1.03e-03	79	105	4	IPR019787
Domain	TB_dom	LTBP4 FBN3	1.10e-03	9	105	2	IPR017878
Domain	TB	LTBP4 FBN3	1.10e-03	9	105	2	PS51364
Domain	Znf_FYVE_PHD	KMT2E PHF21A KMT2C KMT2A PRDM14	1.45e-03	147	105	5	IPR011011
Domain	Laminin_G_2	LAMA5 SLIT3 USH2A	1.47e-03	40	105	3	PF02210
Domain	ZF_RING_2	TRAF2 TRAIP RNF114 KMT2C TRAF4 TRIM13 ZNF598	1.47e-03	298	105	7	PS50089
Domain	PHD	KMT2E PHF21A KMT2C KMT2A	1.60e-03	89	105	4	SM00249
Domain	Znf_PHD	KMT2E PHF21A KMT2C KMT2A	1.73e-03	91	105	4	IPR001965
Domain	MATH	TRAF2 TRAF4	1.99e-03	12	105	2	PS50144
Domain	Znf_TRAF	TRAF2 TRAF4	1.99e-03	12	105	2	IPR001293
Domain	MATH/TRAF_dom	TRAF2 TRAF4	1.99e-03	12	105	2	IPR002083
Domain	MATH	TRAF2 TRAF4	1.99e-03	12	105	2	SM00061
Domain	MATH	TRAF2 TRAF4	1.99e-03	12	105	2	PF00917
Domain	-	LAMA5 SLIT3 USH2A AGRN	2.03e-03	95	105	4	2.60.120.200
Domain	ZF_PHD_2	KMT2E PHF21A KMT2C KMT2A	2.03e-03	95	105	4	PS50016
Domain	ZF_PHD_1	KMT2E PHF21A KMT2C KMT2A	2.11e-03	96	105	4	PS01359
Domain	ZF_TRAF	TRAF2 TRAF4	2.35e-03	13	105	2	PS50145
Domain	-	TRAF2 TRAF4	2.73e-03	14	105	2	2.60.210.10
Domain	PLAC	PAPLN ADAMTS17	2.73e-03	14	105	2	PF08686
Domain	Znf_C3HC4_RING-type	TRAF2 TRAIP RNF114 TRAF4 TRIM13	2.88e-03	172	105	5	IPR018957
Domain	Post-SET_dom	KMT2C KMT2A	3.57e-03	16	105	2	IPR003616
Domain	PostSET	KMT2C KMT2A	3.57e-03	16	105	2	SM00508
Domain	Laminin_N	LAMA5 USH2A	3.57e-03	16	105	2	IPR008211
Domain	LamNT	LAMA5 USH2A	3.57e-03	16	105	2	SM00136
Domain	LAMININ_NTER	LAMA5 USH2A	3.57e-03	16	105	2	PS51117
Domain	Laminin_N	LAMA5 USH2A	3.57e-03	16	105	2	PF00055
Domain	POST_SET	KMT2C KMT2A	3.57e-03	16	105	2	PS50868
Domain	Furin_repeat	CRELD1 RSPO1	4.52e-03	18	105	2	IPR006212
Domain	FU	CRELD1 RSPO1	4.52e-03	18	105	2	SM00261
Domain	EGF_extracell	TEK ADAM8 LRP2	4.68e-03	60	105	3	IPR013111
Domain	EGF_2	TEK ADAM8 LRP2	4.68e-03	60	105	3	PF07974
Domain	PLAC	PAPLN ADAMTS17	5.03e-03	19	105	2	PS50900
Domain	PLAC	PAPLN ADAMTS17	5.03e-03	19	105	2	IPR010909
Domain	TSP_1	PAPLN ADAMTS17 RSPO1	5.37e-03	63	105	3	PF00090
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF562 ZNF473 ZNF658 ZNF689 PSMB6 ZNF343 ZNF225 PPARG ZKSCAN5 GEM ZNF248 KMT2C ZNF20 ZKSCAN3 ZNF566 KMT2A ZNF616 ZNF264 ZNF548 NOTCH2	3.85e-05	1387	77	20	M734
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	NPC1 RAPGEF6 ACACA TMEM94 LAMA5 PAPLN SMG5 ZNF865 LYST WDR59 PLEKHM1 KMT2C TRAF4 MCM3AP LTBP4 AGRN TOP3B NOTCH2 ARHGAP33	1.35e-09	1105	108	19	35748872
Pubmed	Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.	KMT2E KMT2C KMT2A	1.61e-06	8	108	3	23130995
Pubmed	The human RNA surveillance factor UPF1 is required for S phase progression and genome stability.	POLD1 SMG5 UPF2	2.41e-06	9	108	3	16488880
Pubmed	In Vitro Inhibitory Mechanism Effect of TRAIP on the Function of TRAF2 Revealed by Characterization of Interaction Domains.	TRAF2 TRAIP	9.55e-06	2	108	2	30127245
Pubmed	Specific cleavage of agrin by neurotrypsin, a synaptic protease linked to mental retardation.	PRSS12 AGRN	9.55e-06	2	108	2	17586728
Pubmed	Neurotrypsin cleaves agrin locally at the synapse.	PRSS12 AGRN	9.55e-06	2	108	2	18230682
Pubmed	TRAF2 regulates the cytoplasmic/nuclear distribution of TRAF4 and its biological function in breast cancer cells.	TRAF2 TRAF4	9.55e-06	2	108	2	23743189
Pubmed	A mechanoresponsive PINCH-1-Notch2 interaction regulates smooth muscle differentiation of human placental mesenchymal stem cells.	LIMS1 NOTCH2	9.55e-06	2	108	2	33529444
Pubmed	Complete structural characterisation of the mammalian and Drosophila TRAF genes: implications for TRAF evolution and the role of RING finger splice variants.	TRAF2 TRAF4	9.55e-06	2	108	2	11275257
Pubmed	Expression, correlation, and prognostic value of TRAF2 and TRAF4 expression in malignant plural effusion cells in human breast cancer.	TRAF2 TRAF4	9.55e-06	2	108	2	26331901
Pubmed	Genes encoding agrin (AGRN) and neurotrypsin (PRSS12) are associated with muscle mass, strength and plasma C-terminal agrin fragment concentration.	PRSS12 AGRN	9.55e-06	2	108	2	36609795
Pubmed	Madecassic acid, the contributor to the anti-colitis effect of madecassoside, enhances the shift of Th17 toward Treg cells via the PPARγ/AMPK/ACC1 pathway.	ACACA PPARG	9.55e-06	2	108	2	28358365
Pubmed	Destabilization of the neuromuscular junction by proteolytic cleavage of agrin results in precocious sarcopenia.	PRSS12 AGRN	9.55e-06	2	108	2	21885656
Pubmed	Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia.	NPC1 CX3CR1	9.55e-06	2	108	2	33627648
Pubmed	The C-Terminal Fragment of Agrin (CAF), a Novel Marker of Renal Function, Is Filtered by the Kidney and Reabsorbed by the Proximal Tubule.	PRSS12 AGRN	9.55e-06	2	108	2	27380275
Pubmed	Coincident pre- and postsynaptic activation induces dendritic filopodia via neurotrypsin-dependent agrin cleavage.	PRSS12 AGRN	9.55e-06	2	108	2	19303856
Pubmed	ZFP423 controls EBF2 coactivator recruitment and PPARγ occupancy to determine the thermogenic plasticity of adipocytes.	ZNF423 PPARG	2.86e-05	3	108	2	34620682
Pubmed	Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularization.	PPARG TEK	2.86e-05	3	108	2	19801450
Pubmed	Staged suppression of microglial autophagy facilitates regeneration in CNS demyelination by enhancing the production of linoleic acid.	PPARG CX3CR1	2.86e-05	3	108	2	36577069
Pubmed	Maternal obesity induces epigenetic modifications to facilitate Zfp423 expression and enhance adipogenic differentiation in fetal mice.	ZNF423 PPARG	2.86e-05	3	108	2	23884886
Pubmed	Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.	KMT2C KMT2A	2.86e-05	3	108	2	23932714
Pubmed	Megalin/LRP2 expression is induced by peroxisome proliferator-activated receptor -alpha and -gamma: implications for PPARs' roles in renal function.	PPARG LRP2	2.86e-05	3	108	2	21311715
Pubmed	Cathepsin S contributes to microglia-mediated olfactory dysfunction through the regulation of Cx3cl1-Cx3cr1 axis in a Niemann-Pick disease type C1 model.	NPC1 CX3CR1	2.86e-05	3	108	2	27687148
Pubmed	Oxidized lipid-driven chemokine receptor switch, CCR2 to CX3CR1, mediates adhesion of human macrophages to coronary artery smooth muscle cells through a peroxisome proliferator-activated receptor gamma-dependent pathway.	PPARG CX3CR1	2.86e-05	3	108	2	16908772
Pubmed	Germ line activation of the Tie2 and SMMHC promoters causes noncell-specific deletion of floxed alleles.	PPARG TEK	2.86e-05	3	108	2	18612081
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KMT2E KMT2C KMT2A	3.72e-05	21	108	3	27626377
Pubmed	Structural basis for activity regulation of MLL family methyltransferases.	KMT2E KMT2C KMT2A	4.30e-05	22	108	3	26886794
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZNF473 ZNF423 ZNF689 RNF114 PHF21A LIMS1 ZKSCAN3 ZNF566 ZNF616 ZNF598 ZNF653	4.44e-05	808	108	11	20412781
Pubmed	Intestinal Monocyte-Derived Macrophages Control Commensal-Specific Th17 Responses.	CX3CR1 NOTCH2	5.71e-05	4	108	2	26279572
Pubmed	APC-dependent suppression of colon carcinogenesis by PPARgamma.	PPARG LRP2	5.71e-05	4	108	2	12370429
Pubmed	Distinct effects on mRNA export factor GANP underlie neurological disease phenotypes and alter gene expression depending on intron content.	ATXN7L3B MCM3AP	5.71e-05	4	108	2	32202298
Pubmed	Cytoplasmic TRAF4 contributes to the activation of p70s6k signaling pathway in breast cancer.	TRAF2 TRAF4	5.71e-05	4	108	2	25738361
Pubmed	M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway.	MRC2 CX3CR1	5.71e-05	4	108	2	24019537
Pubmed	A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.	KMT2C KMT2A	5.71e-05	4	108	2	23129768
Pubmed	Sirtuin1 promotes osteogenic differentiation through downregulation of peroxisome proliferator-activated receptor γ in MC3T3-E1 cells.	ACACA PPARG	5.71e-05	4	108	2	27378422
Pubmed	Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II.	KMT2C KMT2A	5.71e-05	4	108	2	19703992
Pubmed	The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers.	KMT2C KMT2A	5.71e-05	4	108	2	24081332
Pubmed	An agrin minigene rescues dystrophic symptoms in a mouse model for congenital muscular dystrophy.	LAMA5 AGRN	5.71e-05	4	108	2	11565031
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	TRAF2 ZNF423 LAMA5 WDR59 PLEKHM1 CRELD1 LTBP4 AGRN NOTCH2	6.50e-05	560	108	9	21653829
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	POLD1 TRAIP PCDHA2 CSF2RA ZKSCAN3 LRP2 POLR1B	7.83e-05	329	108	7	17474147
Pubmed	Signalling codes for the maintenance and lineage commitment of embryonic gastric epithelial progenitors.	CDH3 RSPO1 NOTCH2	8.07e-05	27	108	3	32878924
Pubmed	Robo1 modulates proliferation and neurogenesis in the developing neocortex.	ZNF423 SLIT3 NOTCH2	8.07e-05	27	108	3	24741061
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	KMT2E PLEKHM1 KMT2C TPH2 PRDM14 ZNF653	9.18e-05	233	108	6	37704626
Pubmed	Identification and characterization of EBP, a novel EEN binding protein that inhibits Ras signaling and is recruited into the nucleus by the MLL-EEN fusion protein.	SH3D19 KMT2A	9.50e-05	5	108	2	14551139
Pubmed	TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation.	TRAF2 TRAIP	9.50e-05	5	108	2	9104814
Pubmed	Tumor necrosis factor receptor associated factor 4 (TRAF4) expression pattern during mouse development.	TRAF2 TRAF4	9.50e-05	5	108	2	9507120
Pubmed	Notch and TLR signaling coordinate monocyte cell fate and inflammation.	CX3CR1 NOTCH2	9.50e-05	5	108	2	32723480
Pubmed	FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner.	TRAF2 TRAF4	9.50e-05	5	108	2	16184196
Pubmed	Expression of TNF-receptor-associated factor genes in murine tooth development.	TRAF2 TRAF4	9.50e-05	5	108	2	12711536
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	ACACA POLD1 WDR83 ZNF106 POLR1B TOP3B	1.13e-04	242	108	6	34011540
Pubmed	Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation.	ZNF689 CHAMP1 ZNF566 ZNF264	1.34e-04	83	108	4	20562864
Pubmed	Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay.	SMG5 UPF2	1.42e-04	6	108	2	25770585
Pubmed	Laminin alpha1 globular domains 4-5 induce fetal development but are not vital for embryonic basement membrane assembly.	LAMA5 AGRN	1.42e-04	6	108	2	15668394
Pubmed	Tumor necrosis factor receptor-associated factors (TRAFs).	TRAF2 TRAF4	1.42e-04	6	108	2	11607847
Pubmed	AMPK Activation Regulates LTBP4-Dependent TGF-β1 Secretion by Pro-inflammatory Macrophages and Controls Fibrosis in Duchenne Muscular Dystrophy.	LTBP4 CX3CR1	1.42e-04	6	108	2	30463013
Pubmed	The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators.	TRAF2 TRAF4	1.42e-04	6	108	2	11384837
Pubmed	Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation.	TRAF2 TRAF4	1.42e-04	6	108	2	19937093
Pubmed	Tumor necrosis factor (TNF) receptor-associated factor (TRAF)-interacting protein (TRIP) negatively regulates the TRAF2 ubiquitin-dependent pathway by suppressing the TRAF2-sphingosine 1-phosphate (S1P) interaction.	TRAF2 TRAIP	1.42e-04	6	108	2	25716317
Pubmed	Brown-adipose-tissue macrophages control tissue innervation and homeostatic energy expenditure.	SEMA6A CX3CR1	1.42e-04	6	108	2	28459435
Pubmed	Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival.	LAMA5 AGRN	1.42e-04	6	108	2	23847204
Pubmed	Regulation of membrane phospholipid asymmetry by Notch-mediated flippase expression controls the number of intraepithelial TCRαβ+CD8αα+ T cells.	CX3CR1 NOTCH2	1.42e-04	6	108	2	31071093
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	LAMA5 PAPLN ADAMTS17 LTBP4 AGRN	1.80e-04	167	108	5	22159717
Pubmed	A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis.	TRAF2 TRAF4	1.99e-04	7	108	2	11728344
Pubmed	Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7.	SMG5 UPF2	1.99e-04	7	108	2	14636577
Pubmed	Unique Role of the WD-40 Repeat Protein 5 (WDR5) Subunit within the Mixed Lineage Leukemia 3 (MLL3) Histone Methyltransferase Complex.	KMT2C KMT2A	1.99e-04	7	108	2	26324722
Pubmed	Regulation of monocyte cell fate by blood vessels mediated by Notch signalling.	CX3CR1 NOTCH2	1.99e-04	7	108	2	27576369
Pubmed	Differentiation of CD11c+ CX3CR1+ cells in the small intestine requires Notch signaling.	CX3CR1 NOTCH2	1.99e-04	7	108	2	24711412
Pubmed	Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation.	PRSS12 AGRN	1.99e-04	7	108	2	24145027
Pubmed	Gut-resident CX3CR1hi macrophages induce tertiary lymphoid structures and IgA response in situ.	CX3CR1 NOTCH2	1.99e-04	7	108	2	32276965
Pubmed	Molecular characterization of CD40 signaling intermediates.	TRAF2 TRAF4	1.99e-04	7	108	2	11562359
Pubmed	Clustered PHD domains in KMT2/MLL proteins are attracted by H3K4me3 and H3 acetylation-rich active promoters and enhancers.	KMT2C KMT2A	1.99e-04	7	108	2	36598580
Pubmed	Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends.	SMG5 UPF2	1.99e-04	7	108	2	17916692
Pubmed	The expression and the regulatory role of OX40 and 4-1BB heterodimer in activated human T cells.	TRAF2 TRAF4	1.99e-04	7	108	2	15941918
Pubmed	CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization.	TRAF2 TRAF4	1.99e-04	7	108	2	9718306
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	LAMA5 SMG5 CHAMP1 PHF21A KMT2C MAST4 MRC2 SLIT3	2.53e-04	529	108	8	14621295
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF562 ZNF689 ZNF20 ZNF566 ZNF264	2.61e-04	181	108	5	37372979
Pubmed	The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.	KMT2C KMT2A	2.64e-04	8	108	2	22266653
Pubmed	Links between signal transduction, transcription and adhesion in epithelial bud development.	LAMA5 CDH3	2.64e-04	8	108	2	12646922
Pubmed	Fras1 deficiency results in cryptophthalmos, renal agenesis and blebbed phenotype in mice.	LAMA5 AGRN	2.64e-04	8	108	2	12766770
Pubmed	USP7-Dependent Regulation of TRAF Activation and Signaling by a Viral Interferon Regulatory Factor Homologue.	TRAF2 TRAF4	2.64e-04	8	108	2	31666375
Pubmed	H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development.	PPARG KMT2C	2.64e-04	8	108	2	30335158
Pubmed	Global genetic analysis in mice unveils central role for cilia in congenital heart disease.	LAMA5 SLIT3 LRP2 SEMA6A	2.74e-04	100	108	4	25807483
Pubmed	Molecular genetics of successful smoking cessation: convergent genome-wide association study results.	ZNF423 TEK FGF12 USH2A	2.85e-04	101	108	4	18519826
Pubmed	Rab11-FIP1 and Rab11-FIP5 Regulate pIgR/pIgA Transcytosis through TRIM21-Mediated Polyubiquitination.	ACACA KMT2C NOTCH2	2.85e-04	41	108	3	34638806
Pubmed	Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.	KMT2C KMT2A	3.39e-04	9	108	2	22665483
Pubmed	Elongation factor 1 alpha1 and genes associated with Usher syndromes are downstream targets of GBX2.	USH2A NOTCH2	3.39e-04	9	108	2	23144817
Pubmed	ARRB1 ameliorates liver ischaemia/reperfusion injury via antagonizing TRAF6-mediated Lysine 6-linked polyubiquitination of ASK1 in hepatocytes.	TRAF2 TRAF4	3.39e-04	9	108	2	32445435
Pubmed	TRAF-interacting protein (TRIP) is a RING-dependent ubiquitin ligase.	TRAF2 TRAIP	3.39e-04	9	108	2	17544371
Pubmed	Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo.	KMT2C KMT2A PRDM14	3.52e-04	44	108	3	24183668
Pubmed	Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.	NPC1 PPARG NOTCH2	3.52e-04	44	108	3	20712903
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	RAPGEF6 ACACA LYST WDR59 ZNF106 MAST4 SH3D19 KMT2A ZNF598 NOTCH2	3.58e-04	861	108	10	36931259
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	ZNF473 ZNF658 MARS1 YY2 KMT2E CHAMP1 PPP1R8 CRELD1 ZNF106 MRC2 ZNF566 NOTCH2	3.65e-04	1203	108	12	29180619
Pubmed	Basement membrane distortions impair lung lobation and capillary organization in the mouse model for fraser syndrome.	LAMA5 AGRN	4.23e-04	10	108	2	15623520
Pubmed	The TRAF2-p62 axis promotes proliferation and survival of liver cancer by activating mTORC1 pathway.	TRAF2 TRAF4	4.23e-04	10	108	2	37081115
Pubmed	UBE2O negatively regulates TRAF6-mediated NF-κB activation by inhibiting TRAF6 polyubiquitination.	TRAF2 TRAF4	4.23e-04	10	108	2	23381138
Pubmed	TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction.	TRAF2 TRAF4	4.23e-04	10	108	2	10514511
Pubmed	Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.	KMT2E KMT2C KMT2A	4.84e-04	49	108	3	34368113
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZKSCAN3 ZNF566 ZNF616	4.84e-04	49	108	3	9630514
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	MARS1 KMT2C LRP2 KMT2A TDRD12	4.93e-04	208	108	5	33230847
Pubmed	Human transcription factor protein interaction networks.	ACTR8 MARS1 PSMB6 YY2 WDR83 SMG5 PPARG SSBP3 PHF21A KMT2C ZKSCAN3 LRP2 KMT2A	4.95e-04	1429	108	13	35140242
Interaction	ZNF408 interactions	ZNF473 CHAMP1 CRELD1 UPF2 LRP2 LTBP4 TOP3B NOTCH2	1.06e-06	145	107	8	int:ZNF408
Interaction	TRIM41 interactions	ZNF562 ZNF473 TRAIP ZNF343 ZNF835 ZNF264 PRDM14 TOP3B ZNF653	2.97e-06	223	107	9	int:TRIM41
Interaction	TOP3B interactions	NPC1 RAPGEF6 ACACA TMEM94 LAMA5 PAPLN SMG5 ZNF865 LYST WDR59 PLEKHM1 CCNF KMT2C TRAF4 UPF2 MCM3AP ZNF598 LTBP4 AGRN TOP3B NOTCH2 ARHGAP33	7.80e-06	1470	107	22	int:TOP3B
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	CAPN12 ZNF473 OVOL3 POLD1 ZNF225 ZNF865 ZNF835 ZNF566 ZNF616 ZNF264 LTBP4 ZNF548 ARHGAP33 TDRD12	8.49e-07	1192	108	14	chr19q13
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF562 ZNF473 ZNF658 ZNF423 ZNF689 YY2 ZNF343 ZNF225 CHAMP1 ZNF865 ZKSCAN5 ZNF835 ZNF248 ZNF106 ZNF20 ZKSCAN3 ZNF566 ZNF616 ZNF264 ZNF598 PRDM14 ZNF548 ZNF653	3.40e-14	718	80	23	28
GeneFamily	TNF receptor associated factors	TRAF2 TRAF4	4.00e-04	7	80	2	1056
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2E KMT2C KMT2A	4.52e-04	34	80	3	487
GeneFamily	PHD finger proteins	KMT2E PHF21A KMT2C KMT2A	6.80e-04	90	80	4	88
Coexpression	NABA_ECM_GLYCOPROTEINS	ZPLD1 LAMA5 PAPLN CRELD1 SLIT3 USH2A LTBP4 RSPO1 AGRN FBN3	8.14e-09	196	107	10	M3008
Coexpression	NABA_CORE_MATRISOME	ZPLD1 LAMA5 PAPLN CRELD1 SLIT3 USH2A LTBP4 RSPO1 AGRN FBN3	1.97e-07	275	107	10	M5884
Coexpression	NABA_ECM_GLYCOPROTEINS	ZPLD1 LAMA5 PAPLN CRELD1 SLIT3 LTBP4 RSPO1 AGRN	1.21e-06	191	107	8	MM17059
Coexpression	OISHI_CHOLANGIOMA_STEM_CELL_LIKE_UP	ZNF562 ZNF473 PSMB6 SMG5 ZNF225 ZKSCAN5 ZNF20 ZNF264 TOP3B	1.35e-05	349	107	9	M283
Coexpression	NABA_CORE_MATRISOME	ZPLD1 LAMA5 PAPLN CRELD1 SLIT3 LTBP4 RSPO1 AGRN	1.55e-05	270	107	8	MM17057
Coexpression	NABA_MATRISOME	ZPLD1 PRSS12 LAMA5 PAPLN ADAM8 CRELD1 SLIT3 ADAMTS17 FGF12 SEMA6A USH2A LTBP4 RSPO1 AGRN FBN3	1.82e-05	1026	107	15	M5889
Coexpression	THAKAR_PBMC_INACTIVATED_INFLUENZA_AGE_21_30YO_RESPONDERS_28DY_DN	SMG5 GIT2 ADAM8 DHRS1 WDR59 PLEKHM1 CSF2RA MCM3AP AP4B1 ZNF598 LTBP4 TOP3B ZNF548 ARHGAP33	1.91e-05	905	107	14	M40865
Coexpression	NABA_BASEMENT_MEMBRANES	LAMA5 PAPLN USH2A AGRN	2.14e-05	40	107	4	M5887
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPN12 ZNF473 ZNF423 SLIT3 LTBP4 ARHGAP33	3.71e-06	170	108	6	50c6c571591aa4b218caefe5778c570c809f567e
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPN12 ZNF473 ZNF423 SLIT3 LTBP4 ARHGAP33	3.71e-06	170	108	6	8fe32dcf924d5f6665f7febbc9647d96b1e96f06
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPN12 ZNF473 ZNF423 SLIT3 LTBP4 ARHGAP33	3.71e-06	170	108	6	3232db50b1a40f861e981a1b9c9073b81af9f832
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GJB3 MRC2 SLIT3 LRP2 LTBP4 RSPO1	6.40e-06	187	108	6	4e553721fa5598cb211f44e3226280b7e6885484
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GJB3 MRC2 SLIT3 LRP2 LTBP4 RSPO1	6.40e-06	187	108	6	d36e7fc6125e7a4310499365022d38f34b757a73
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GJB3 MRC2 SLIT3 LRP2 LTBP4 RSPO1	6.40e-06	187	108	6	827eae63fabf6892a82ce7779b5f395958d3d628
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GEM ZNF106 MRC2 SH3D19 SLIT3 LTBP4	8.62e-06	197	108	6	94a9603cbd3516fbcce871909693b88f20d41713
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Dendritic-conventional_dendritic_cell-DC_c1-CLEC9A\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PRSS12 ZNF423 SEMA6A USH2A CDH3	1.70e-05	131	108	5	1823cab28fab40486247ca92104267b1e370bdc1
Drug	Labetalol hydrochloride [32780-64-6]; Down 200; 11uM; MCF7; HT_HG-U133A	ZNF473 MARS1 GIT2 ZKSCAN5 TRAF4 MCM3AP LTBP4 AGRN	4.41e-06	196	108	8	3167_DN
Drug	Spiramycin [8025-81-8]; Down 200; 4.8uM; HL60; HT_HG-U133A	TRAF2 MARS1 WDR59 CRELD1 ZNF20 LY9 AGRN TOP3B	4.58e-06	197	108	8	2558_DN
Drug	Dimenhydrinate [523-87-5]; Down 200; 8.6uM; PC3; HT_HG-U133A	ZNF473 LAMA5 ADAM8 ZKSCAN5 CRELD1 ZNF20 GJB3 CDH3	4.75e-06	198	108	8	6352_DN
Drug	DAPH; Up 200; 10uM; PC3; HG-U133A	ZNF562 SMG5 TRAF4 GJB3 MAST4 MRC2 SLIT3 CDH3	4.93e-06	199	108	8	578_UP
Disease	pulmonary alveolar proteinosis (implicated_via_orthology)	MARS1 CSF2RA	1.20e-04	5	103	2	DOID:12120 (implicated_via_orthology)
Disease	MENTAL RETARDATION, AUTOSOMAL DOMINANT 40	KMT2E CHAMP1	4.28e-04	9	103	2	C4225275
Disease	decadienedioic acid (C10:2-DC) measurement	HEATR4 PAPLN	5.33e-04	10	103	2	EFO_0800598
Disease	Sensory hearing loss	GJB3 LRP2	6.50e-04	11	103	2	C1691779
Disease	Precursor Cell Lymphoblastic Leukemia Lymphoma	KMT2A PRDM14 NOTCH2	1.28e-03	61	103	3	C1961102
Disease	Myeloid Leukemia	KMT2E KMT2A	1.78e-03	18	103	2	C0023470
Disease	Leukemia, Monocytic, Chronic	KMT2E KMT2A	1.78e-03	18	103	2	C0023466
Disease	congenital heart disease (implicated_via_orthology)	KMT2C LRP2 KMT2A	1.83e-03	69	103	3	DOID:1682 (implicated_via_orthology)
Disease	Liver carcinoma	ACACA TRAIP PPARG CCNF KMT2C KMT2A MTBP	2.04e-03	507	103	7	C2239176
Disease	Deaf Mutism	POLD1 GJB3	2.20e-03	20	103	2	C4082305
Disease	Deafness, Acquired	POLD1 GJB3	2.20e-03	20	103	2	C0751068
Disease	Hearing Loss, Extreme	POLD1 GJB3	2.20e-03	20	103	2	C0086395
Disease	Complete Hearing Loss	POLD1 GJB3	2.20e-03	20	103	2	C0581883
Disease	Prelingual Deafness	POLD1 GJB3	2.20e-03	20	103	2	C0011052
Disease	Bilateral Deafness	POLD1 GJB3	2.20e-03	20	103	2	C3665473
Disease	amblyopia	ZPLD1 MALRD1	2.66e-03	22	103	2	MONDO_0001020
Disease	nephrosis (biomarker_via_orthology)	LRP2 CX3CR1	2.66e-03	22	103	2	DOID:2527 (biomarker_via_orthology)
Disease	Sensorineural Hearing Loss (disorder)	GJB3 LRP2	2.91e-03	23	103	2	C0018784
Disease	post-traumatic stress disorder symptom measurement	TRAIP PCDHA2 PLEKHM1	3.00e-03	82	103	3	EFO_0008535
Disease	Giant Cell Glioblastoma	PPARG LTBP4 NOTCH2	3.21e-03	84	103	3	C0334588
Disease	Leukemia, Myelocytic, Acute	KMT2C KMT2A AGRN NOTCH2	3.21e-03	173	103	4	C0023467
Disease	Deafness	POLD1 GJB3	3.44e-03	25	103	2	C0011053

Protein segments in the cluster

Peptide	Gene	Start	Entry
HFSRCGEVHRVTILC	PABPN1L	166	A6NDY0
IEDSCLGFCFEVHRA	ATXN7L3B	26	Q96GX2
VCCVEDGVSHRNTRL	ACTR8	291	Q9H981
CEFGARCVEESGSAH	AGRN	906	O00468
SSESRELCFVALCHV	AP4B1	286	Q9Y6B7
THCTVCDDFEGVFTV	ACACA	1881	Q13085
CLAVLCGRSVHVDFS	CX3CR1	311	P49238
RGTFLCDECCSVHRS	GIT2	26	Q14161
CIVDVCHALTTEDGT	ADAM8	566	P78325
EDTCIHSREVGVVCS	CD163L1	881	Q9NR16
TDGRVCVDTHVRSTC	FBN3	606	Q75N90
FVTRTDFCVHKDEPC	ADAMTS17	341	Q8TE56
IHDRIFCCRSGSAAD	PSMB6	71	P28072
VSVSEGRACAVVFDC	GEM	201	P55040
CGRSAECSIHVEVIV	PCDHA2	96	Q9Y5H9
VCRSAFTGRHCETFV	NOTCH2	1291	Q04721
GVCSKSDFECHRLLE	CRELD1	96	Q96HD1
GRHDCSHREDVSIAC	PRSS12	471	P56730
AVVSGSTERCAFCKH	KMT2C	276	Q8NEZ4
STERCAFCKHLGATI	KMT2C	281	Q8NEZ4
CLIGESFEEHSREVC	EIF4E1B	161	A6NMX2
RDCEEATDFLTCHGL	MCM3AP	911	O60318
STDGDIHEDFCSVCR	PHF21A	481	Q96BD5
TDVTRCICGFTHDDG	KMT2E	116	Q8IZD2
RSCTEETHGFICQKG	MRC2	1096	Q9UBG0
CTFGFQLDTDERHCI	LRP2	691	P98164
HCERCQAGFVSSRDD	LAMA5	1891	O15230
CGISVEFCSHITRAF	NPC1	1161	O15118
EKLHVCEDCGFTSSR	OVOL3	186	O00110
TDNEFICRSDGHCIE	MALRD1	1051	Q5VYJ5
VLRCCSEFIEAHGVV	ARHGAP33	331	O14559
RDSGHIVKCLDSFCD	CFAP300	121	Q9BRQ4
DFERFVSCVAHLTCI	CAPN12	676	Q6ZSI9
GSCCKAVVHESLRAE	CCNF	161	P41002
REVHCFCVVSHSVLD	FBXL8	331	Q96CD0
SARLECDHCSFRGTD	CHAMP1	11	Q96JM3
HCFSDDFTAVRRAAC	HEATR4	736	Q86WZ0
VGHVHCREIICSVAF	LYST	3696	Q99698
HSEDGICRISLTCSV	LY9	371	Q9HBG7
HFCTTESIATENRCR	MAST4	331	O15021
HLHRGRCTDVDECSS	LTBP4	826	Q8N2S1
CERDGRVRTCHAEAF	CDH18	591	Q13634
LFCVAEERSGHCAVV	KLHDC1	6	Q8N7A1
RVVCFLCASSGHVEF	KMT2A	1431	Q03164
SEDSGSHCTRECRKE	CCDC168	6836	Q8NDH2
ASTCRCHHKLVEAGE	GJB3	236	O75712
DCAHELRRHGVSCVS	DHRS1	176	Q96LJ7
CQGSLHEDVICTSRD	POLD1	1061	P28340
TVIRATVCDCHGHVE	CDH3	631	P22223
CTFREICLHEGVTFE	CSF2RA	81	P15509
HFCSSSVSEDLGCRR	GARNL3	21	Q5VVW2
HECFTACSQRLFEIS	MTBP	851	Q96DY7
SVVISFCRHCGDDIA	UPF2	306	Q9HAU5
CERHVLGVFSKVRFC	FGF12	41	P61328
DTTVRCAECKTVFHQ	PLEKHM1	1016	Q9Y4G2
CDFNFTSHICTVIRG	USH2A	3416	O75445
AVEDHFELCLAKCRT	SPRING1	161	Q9H741
HGIVRTKVDDCQFVC	RAPGEF6	356	Q8TEU7
CAAPERRDTCEHSSE	SSBP3	71	Q9BWW4
DLCDFTIDHQSCSRV	PPP1R8	56	Q12972
VRRSHKEDDGCSCSI	PRDM14	536	Q9GZV8
ESVVRICCIRSFGHF	SMG5	761	Q9UPR3
VSSHCVKGSRCVARF	SH3D19	566	Q5HYK7
ARGCDVVVISHCESN	TDRD12	451	Q587J7
AIECRVCGDKASGFH	PPARG	136	P37231
DHAACSDTKETRRCT	RSPO1	186	Q2MKA7
VCFHCNRVIEGDVVS	LIMS1	251	P48059
SFVEEVERHLECGCL	SLIT3	1506	O75094
CRFHAIGCLETVEGE	TRAF2	216	Q12933
AHRVRVSADTCSVCE	TOP3B	761	O95985
ECVECGKTFITSSHR	ZNF562	401	Q6V9R5
IHSGVREFTCETCGK	ZNF653	521	Q96CK0
ECGRGFCDKSTLIIH	ZNF343	441	Q6P1L6
CGRGFCDKSTLIVHE	ZNF343	526	Q6P1L6
TVFLHCVTKLCRADD	ZPLD1	291	Q8TCW7
VVHTGERAFKCGVCA	ZNF865	896	P0CJ78
CGKAFIRASSCREHE	ZNF20	511	P17024
CDECGKVFRHSSHLV	ZNF616	691	Q08AN1
ICATRGEHTKHVFCS	TRIM13	116	O60858
FSEDCLRKSRVEFCH	TNIP3	176	Q96KP6
ERQIESTETSCHGCR	RNF114	81	Q9Y508
DGSCRVVGCDHELDS	PAPLN	151	O95428
ASVTERLCRFSDHLC	TMEM94	596	Q12767
SGITVYCVCDHRRKD	SEMA6A	666	Q9H2E6
RVHVCAECGKAFLES	YY2	281	O15391
HRFCDTCLQEFLSEG	TRAF4	36	Q9BUZ4
ELHTFGRTCKERCSG	TEK	256	Q02763
RDTHVVSCSEDGKVF	WDR83	246	Q9BRX9
RRSSEVEIFVDCECG	TPH2	101	Q8IWU9
IEFGVYCSHCRSEVR	WDR59	896	Q6PJI9
ECNECGRSFAHISVL	ZNF658	631	Q5TYW1
VRVHSGETTFKCEEC	ZNF225	391	Q9UK10
NRRHTGEKSFVCTEC	ZNF264	306	O43296
LCEEGRCSTEQFTHA	ZNF598	241	Q86UK7
ACEHCEARFSQRSTL	ZNF689	346	Q96CS4
AHGGCCREDKVVASR	ZKSCAN3	191	Q9BRR0
ECGKTFICGSDLTRH	ZNF566	231	Q969W8
VHTSERTYECRECGK	ZNF548	246	Q8NEK5
CADCGKAFTRVTHLT	ZNF835	196	Q9Y2P0
DDCSGIFCLEHRSRE	ZFAND1	26	Q8TCF1
HKCIFCGETFSTEVE	ZNF423	781	Q2M1K9
VEDFLARSCVGRCHS	TRAPPC3L	56	Q5T215
DRLFNCSDRSVAHVC	POLR1B	1056	Q9H9Y6
HCARFLADRFVEGVC	MARS1	391	P56192
RDISHECRVCGVTEV	ZNF106	16	Q9H2Y7
RRAHTGEKTFECGEC	ZNF248	371	Q8NDW4
SREKSHQCRECGEIF	ZKSCAN5	656	Q9Y2L8
GERFICGSTLKCHES	ZNF473	521	Q8WTR7
CGSTLKCHESVHARE	ZNF473	526	Q8WTR7
LCTICSDFFDHSRDV	TRAIP	6	Q9BWF2
ECNECGRSFAHISVL	ZNF658B	391	Q4V348