Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionnuclear receptor activity

NR2C1 NR2C2 NR2F6 AR NR2F1 NR2F2

8.74e-06601616GO:0004879
GeneOntologyMolecularFunctionligand-activated transcription factor activity

NR2C1 NR2C2 NR2F6 AR NR2F1 NR2F2

9.63e-06611616GO:0098531
GeneOntologyMolecularFunctionG protein-coupled glutamate receptor activity

GRM1 GRM2 GRM3

4.17e-0591613GO:0098988
GeneOntologyMolecularFunctionadenylate cyclase inhibiting G protein-coupled glutamate receptor activity

GRM1 GRM2 GRM3

4.17e-0591613GO:0001640
GeneOntologyMolecularFunctionglutamate receptor activity

GRM1 GRM2 GRM3 GRIN3B

6.18e-05271614GO:0008066
GeneOntologyMolecularFunctiongroup II metabotropic glutamate receptor activity

GRM2 GRM3

6.46e-0521612GO:0001641
GeneOntologyMolecularFunctioncorticotropin-releasing hormone receptor activity

CRHR1 CRHR2

1.93e-0431612GO:0043404
GeneOntologyMolecularFunctioncorticotrophin-releasing factor receptor activity

CRHR1 CRHR2

1.93e-0431612GO:0015056
GeneOntologyBiologicalProcesssynaptic transmission, glutamatergic

MYO5A LRRK2 VPS54 GRM1 GRM2 GRM3 ADRB2 CCL2 GRIN3B

1.01e-061321629GO:0035249
GeneOntologyBiologicalProcessregulation of protein autoubiquitination

LRRK2 MTA1 TAF1

9.35e-0661623GO:1902498
GeneOntologyBiologicalProcessadenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

GRM1 GRM2 GRM3

3.86e-0591623GO:0007196
GeneOntologyCellularComponentaxon

CFH MAF1 OPN4 MYO5A DTNA LRRK2 GIT2 GRM1 GRM2 GRM3 AR GFRA1 CRHR2 MADD ADRB2 DST CCL2 TANC1 PLEC IL1R1 KIF1C

5.65e-0689116221GO:0030424
GeneOntologyCellularComponentsomatodendritic compartment

CFH MAF1 OPN4 MYO5A DTNB SYNE1 LRRK2 CLSTN2 GRM1 GRM2 GRM3 AR GFRA1 CRHR1 CRHR2 ADRB2 MTNR1A KNDC1 CCL2 TANC1 PLEC GRIN3B MOB4 KIF1C SOS1

8.83e-06122816225GO:0036477
GeneOntologyCellularComponentdendrite

MAF1 OPN4 MYO5A DTNB SYNE1 LRRK2 CLSTN2 GRM1 GRM2 GRM3 AR CRHR1 CRHR2 ADRB2 KNDC1 CCL2 TANC1 PLEC MOB4 KIF1C

1.13e-0585816220GO:0030425
GeneOntologyCellularComponentdendritic tree

MAF1 OPN4 MYO5A DTNB SYNE1 LRRK2 CLSTN2 GRM1 GRM2 GRM3 AR CRHR1 CRHR2 ADRB2 KNDC1 CCL2 TANC1 PLEC MOB4 KIF1C

1.17e-0586016220GO:0097447
MousePhenoabnormal Bruch membrane morphology

CFH ABCA4 ABCC6 CCL2

6.65e-06141304MP:0005239
DomainZnf_hrmn_rcpt

NR2C1 NR2C2 NR2F6 AR NR2F1 NR2F2

2.45e-06461596IPR001628
DomainNUCLEAR_REC_DBD_2

NR2C1 NR2C2 NR2F6 AR NR2F1 NR2F2

2.45e-06461596PS51030
DomainNUCLEAR_REC_DBD_1

NR2C1 NR2C2 NR2F6 AR NR2F1 NR2F2

2.45e-06461596PS00031
DomainZnF_C4

NR2C1 NR2C2 NR2F6 AR NR2F1 NR2F2

2.45e-06461596SM00399
Domainzf-C4

NR2C1 NR2C2 NR2F6 AR NR2F1 NR2F2

2.45e-06461596PF00105
Domain-

NR2C1 NR2C2 NR2F6 AR NR2F1 NR2F2

2.79e-064715961.10.565.10
DomainNucl_hrmn_rcpt_lig-bd

NR2C1 NR2C2 NR2F6 AR NR2F1 NR2F2

3.16e-06481596IPR000536
DomainHOLI

NR2C1 NR2C2 NR2F6 AR NR2F1 NR2F2

3.16e-06481596SM00430
DomainHormone_recep

NR2C1 NR2C2 NR2F6 AR NR2F1 NR2F2

3.16e-06481596PF00104
DomainCOUP_TF

NR2F6 NR2F1 NR2F2

5.98e-0651593IPR003068
Domain-

NR2C1 NR2C2 NR2F6 AR NR2F1 NR2F2

8.78e-065715963.30.50.10
DomainZnf_NHR/GATA

NR2C1 NR2C2 NR2F6 AR NR2F1 NR2F2

9.72e-06581596IPR013088
Domain-

EVPL DST PLEC

1.19e-05615933.90.1290.10
DomainPeripla_BP_I

GRM1 GRM2 GRM3 GUCY2C GRIN3B

1.91e-05391595IPR028082
DomainPlectin

EVPL DST PLEC

2.07e-0571593PF00681
DomainPlectin_repeat

EVPL DST PLEC

2.07e-0571593IPR001101
DomainPLEC

EVPL DST PLEC

2.07e-0571593SM00250
DomainGPCR_3_mtglu_rcpt

GRM1 GRM2 GRM3

3.29e-0581593IPR000162
DomainARM-type_fold

DOCK11 UBR4 LRRK2 TEX10 ARMC2 PPP4R4 RANBP17 URB1 PIK3C2G PI4KA HEATR5B TANGO6

3.45e-0533915912IPR016024
DomainNuclear_hrmn_rcpt

NR2C1 NR2C2 NR2F6 NR2F1 NR2F2

4.34e-05461595IPR001723
DomainDistrobrevin

DTNA DTNB

7.20e-0521592IPR017432
DomainSpectrin_repeat

SYNE1 EVPL DST PLEC

1.02e-04291594IPR002017
DomainSPEC

SYNE1 EVPL DST PLEC

1.51e-04321594SM00150
DomainSpectrin/alpha-actinin

SYNE1 EVPL DST PLEC

1.51e-04321594IPR018159
DomainNCD3G

GRM1 GRM2 GRM3

1.63e-04131593PF07562
DomainGPCR_3_9-Cys_dom

GRM1 GRM2 GRM3

1.63e-04131593IPR011500
DomainGPCR_3_CS

GRM1 GRM2 GRM3

2.06e-04141593IPR017979
DomainGPCR_2_CRF_rcpt

CRHR1 CRHR2

2.15e-0431592IPR003051
DomainANF_lig-bd_rcpt

GRM1 GRM2 GRM3 GUCY2C

2.68e-04371594IPR001828
DomainANF_receptor

GRM1 GRM2 GRM3 GUCY2C

2.68e-04371594PF01094
DomainRasGEFN

RALGDS KNDC1 SOS1

6.21e-04201593SM00229
DomainRasGEF_N

RALGDS KNDC1 SOS1

7.19e-04211593PF00618
DomainGPCR_3

GRM1 GRM2 GRM3

7.19e-04211593IPR000337
Domain7tm_3

GRM1 GRM2 GRM3

8.28e-04221593PF00003
DomainG_PROTEIN_RECEP_F3_2

GRM1 GRM2 GRM3

8.28e-04221593PS00980
DomainG_PROTEIN_RECEP_F3_3

GRM1 GRM2 GRM3

8.28e-04221593PS00981
DomainG_PROTEIN_RECEP_F3_1

GRM1 GRM2 GRM3

8.28e-04221593PS00979
DomainRas-like_Gua-exchang_fac_N

RALGDS KNDC1 SOS1

8.28e-04221593IPR000651
DomainG_PROTEIN_RECEP_F3_4

GRM1 GRM2 GRM3

8.28e-04221593PS50259
DomainRASGEF_NTER

RALGDS KNDC1 SOS1

8.28e-04221593PS50212
DomainGPCR_3_C

GRM1 GRM2 GRM3

8.28e-04221593IPR017978
DomainACTININ_2

SYNE1 DST PLEC

9.46e-04231593PS00020
DomainACTININ_1

SYNE1 DST PLEC

9.46e-04231593PS00019
DomainActinin_actin-bd_CS

SYNE1 DST PLEC

9.46e-04231593IPR001589
DomainEF-hand_dom_typ1

DTNA DTNB

1.06e-0361592IPR015153
DomainEF-hand_dom_typ2

DTNA DTNB

1.06e-0361592IPR015154
DomainEF-hand_2

DTNA DTNB

1.06e-0361592PF09068
DomainEF-hand_3

DTNA DTNB

1.06e-0361592PF09069
DomainRASGEF

RALGDS KNDC1 SOS1

1.36e-03261593PS00720
DomainZnF_UBR1

UBR4 UBR3

1.47e-0371592SM00396
DomainZF_UBR

UBR4 UBR3

1.47e-0371592PS51157
Domainzf-UBR

UBR4 UBR3

1.47e-0371592PF02207
DomainZnf_UBR

UBR4 UBR3

1.47e-0371592IPR003126
DomainRASGEF_CAT

RALGDS KNDC1 SOS1

1.88e-03291593PS50009
DomainEPL1

BRPF3 EPC1

1.95e-0381592PF10513
DomainEnhancer_polycomb-like_N

BRPF3 EPC1

1.95e-0381592IPR019542
DomainRasGEF

RALGDS KNDC1 SOS1

2.08e-03301593PF00617
Domain-

RALGDS KNDC1 SOS1

2.08e-033015931.10.840.10
DomainRASGEF_cat_dom

RALGDS KNDC1 SOS1

2.08e-03301593IPR001895
DomainRasGEF

RALGDS KNDC1 SOS1

2.08e-03301593SM00147
DomainRas_GEF_dom

RALGDS KNDC1 SOS1

2.08e-03301593IPR023578
DomainPI3Ka

PIK3C2G PI4KA

2.49e-0391592PF00613
DomainPI3Ka

PIK3C2G PI4KA

2.49e-0391592SM00145
DomainDUF3699

GARIN5A GARIN3

2.49e-0391592IPR022168
Domain-

PIK3C2G PI4KA

2.49e-03915921.25.40.70
DomainDUF3699

GARIN5A GARIN3

2.49e-0391592PF12480
Domain-

LRRK2 TEX10 ARMC2 PPP4R4 RANBP17 HEATR5B TANGO6

2.96e-0322215971.25.10.10
DomainHEAT_REPEAT

TEX10 PPP4R4 HEATR5B TANGO6

3.00e-03701594PS50077
DomainPI_Kinase

PIK3C2G PI4KA

3.10e-03101592IPR015433
DomainPInositide-3_kin_accessory_dom

PIK3C2G PI4KA

3.10e-03101592IPR001263
DomainPIK_HELICAL

PIK3C2G PI4KA

3.10e-03101592PS51545
DomainPH

PLEKHG4 DOCK11 PREX2 IRS2 PLEKHM3 PLD2 SOS1

3.52e-032291597PF00169
DomainBAH

MTA1 MTA3

3.77e-03111592PS51038
DomainBAH_dom

MTA1 MTA3

3.77e-03111592IPR001025
DomainBAH

MTA1 MTA3

3.77e-03111592SM00439
DomainBAH

MTA1 MTA3

3.77e-03111592PF01426
DomainGDS_CDC24_CS

PLEKHG4 PREX2 SOS1

4.42e-03391593IPR001331
DomainZnF_GATA

MTA1 MTA3

4.49e-03121592SM00401
DomainELM2_dom

MTA1 MTA3

5.28e-03131592IPR000949
DomainELM2

MTA1 MTA3

5.28e-03131592PF01448
DomainELM2

MTA1 MTA3

5.28e-03131592PS51156
DomainELM2

MTA1 MTA3

5.28e-03131592SM01189
DomainABC_transporter_CS

ABCA4 ABCC5 ABCC6

5.45e-03421593IPR017871
DomainVitD_rcpt

NR2C1 NR2C2

6.13e-03141592IPR000324
DomainRas_G-nucl-exch_fac_CS

RALGDS SOS1

6.13e-03141592IPR019804
DomainPX

PIK3C2G PLD2 SNX11

6.21e-03441593SM00312
Domain-

PLEKHG4 DOCK11 PREX2 PTPN14 RABGAP1L IRS2 PLEKHM3 PLD2 SOS1

6.40e-0339115992.30.29.30
DomainPI3/4_kinase_CS

PIK3C2G PI4KA

7.03e-03151592IPR018936
DomainZnf_GATA

MTA1 MTA3

7.03e-03151592IPR000679
DomainGATA

MTA1 MTA3

7.03e-03151592PF00320
DomainAAA

DNAH3 ABCA4 ABCC5 RFC4 ABCC6

7.83e-031441595SM00382
DomainAAA+_ATPase

DNAH3 ABCA4 ABCC5 RFC4 ABCC6

7.83e-031441595IPR003593
DomainABC_tran

ABCA4 ABCC5 ABCC6

7.91e-03481593PF00005
DomainABC_TRANSPORTER_2

ABCA4 ABCC5 ABCC6

7.91e-03481593PS50893
DomainGATA_ZN_FINGER_1

MTA1 MTA3

7.99e-03161592PS00344
Domain-

PIK3C2G PI4KA

7.99e-031615921.10.1070.11
DomainGATA_ZN_FINGER_2

MTA1 MTA3

7.99e-03161592PS50114
DomainPI3Kc

PIK3C2G PI4KA

7.99e-03161592SM00146
DomainABC_TRANSPORTER_1

ABCA4 ABCC5 ABCC6

8.38e-03491593PS00211
DomainPX

PIK3C2G PLD2 SNX11

8.38e-03491593PF00787
PathwayWP_NUCLEAR_RECEPTORS

NR2C2 NR2F6 AR NR2F1 NR2F2

1.34e-05381155M39657
PathwayWP_NUCLEAR_RECEPTORS

NR2C2 NR2F6 AR NR2F1 NR2F2

1.34e-05381155MM15865
PathwayWP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY

SYNE1 ADCY7 YY1AP1 PLEC SOS1

3.48e-05461155M39828
PathwayREACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY

NR2C1 NR2C2 NR2F6 AR NR2F1

4.28e-05481155MM14987
PathwayREACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY

NR2C1 NR2C2 NR2F6 AR NR2F1

6.95e-05531155M8276
PathwayWP_GPCRS_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE

GRM1 GRM2 GRM3

2.24e-04151153M39442
PathwayWP_GPCRS_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE

GRM1 GRM2 GRM3

2.24e-04151153MM15845
Pubmed

Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells.

GRM1 GRM2 GRM3

1.05e-073165334620856
Pubmed

The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity.

NR2F6 NR2F1 NR2F2

1.05e-073165318701084
Pubmed

Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor.

NR2C2 NR2F6 NR2F1

1.05e-073165310644740
Pubmed

Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system.

GRM1 GRM2 GRM3

4.18e-074165329079293
Pubmed

Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

INTU BRPF3 WWC3 SYNE1 BIRC6 CRACD MTA3

6.44e-07103165710574462
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

TET2 DOCK11 ZNF629 DYRK4 PPP4R4 MADD PTPN14 DST PI4KA DSTYK RABGAP1L IRS2 TANC1 PLEKHM3 PLEC TRAPPC9 KIF1C

8.24e-078611651736931259
Pubmed

Cloning and expression during development of three murine members of the COUP family of nuclear orphan receptors.

NR2F6 NR2F1 NR2F2

2.08e-06616537947324
Pubmed

Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q.

GRM1 GRM2 GRM3

2.08e-06616538824806
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

CFH TET2 NR2C1 MYO5A SYNE1 UBR4 ABCC5 LMO3 VPS54 LRP1B MADD MTA1 DST MTA3 YY1AP1 TAF1 SGSM3 PLEC USP47 SOS1

3.32e-0612851652035914814
Pubmed

A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors.

NR2F6 AR NR2F1 NR2F2

3.34e-0622165423975195
Pubmed

Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion.

GRM1 GRM2 GRM3

3.62e-06716539920659
Pubmed

Glutamate can act as a signaling molecule in mouse preimplantation embryos†.

GRM1 GRM2 GRM3 GRIN3B

4.82e-0624165435746896
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

TET2 NR2C1 NR2C2 UBR4 BIRC6 DST IRS2 TAF1 PLEC ZNF687 TANGO6

5.58e-064181651134709266
Pubmed

Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins.

GRM1 GRM2 GRM3

5.77e-068165311850456
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

IL12RB2 INTU BRPF3 POLR2B ZNF629 CLSTN2 RFC4 PTPN14 MTA1 MTA3 CIBAR1 EPC1 SUPT16H IRS2 TANC1 TAF1 ZNF687 SOS1

6.57e-0611161651831753913
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

MYO5A DTNA DTNB POLR2B TEX10 BIRC6 PPP4R4 MADD PTPN14 PTPRG WDR11 PI4KA SUPT16H UBR3 TANC1 UTP3 AJUBA

1.13e-0510491651727880917
Pubmed

Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.

GRM1 GRM2 GRM3

1.23e-051016539069281
Pubmed

Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase.

NR2C1 NR2C2 AR

1.68e-0511165312943985
Pubmed

Genetic variation associated with preterm birth: a HuGE review.

ADRB2 IL1R1 IL4

1.68e-0511165316301860
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

SEMA3F NR2F6 UBR4 BIRC6 ADCY7 NR2F2 MADD URB1 DST PI4KA IRS2 TANC1 PLEC SNX11 TRAPPC9 ZNF687 MVB12B

2.20e-0511051651735748872
Pubmed

A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread.

IL12RB2 IL1R1 IL4

2.24e-0512165322980983
Pubmed

Selective silencing of individual dendritic branches by an mGlu2-activated potassium conductance in dentate gyrus granule cells.

GRM2 GRM3

2.24e-052165223616537
Pubmed

Assignment to chromosome 11 of mouse p68 RNA helicase gene (Hlr1) and pseudogene (Hlr1-ps1).

DDX5 IL4

2.24e-05216527729546
Pubmed

Molecular mechanisms of corticotropin-releasing factor receptor-induced calcium signaling.

CRHR1 CRHR2

2.24e-052165219098121
Pubmed

Novel corticotropin-releasing hormone receptor genes (CRHR1 and CRHR2) linkage to and association with polycystic ovary syndrome.

CRHR1 CRHR2

2.24e-052165237543650
Pubmed

The effect of local IL-4 delivery or CCL2 blockade on implant fixation and bone structural properties in a mouse model of wear particle induced osteolysis.

CCL2 IL4

2.24e-052165227114284
Pubmed

Factor H and CFHR1 polymorphisms associated with atypical Haemolytic Uraemic Syndrome (aHUS) are differently expressed in Tunisian and in Caucasian populations.

CFH CFHR1

2.24e-052165222136554
Pubmed

The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection.

GRM2 GRM3

2.24e-052165217670976
Pubmed

Deciphering the ligand-binding sites in the Borrelia burgdorferi complement regulator-acquiring surface protein 2 required for interactions with the human immune regulators factor H and factor H-like protein 1.

CFH CFHR1

2.24e-052165218824548
Pubmed

Spatial transcriptomics identifies spatially dysregulated expression of GRM3 and USP47 in amyotrophic lateral sclerosis.

GRM3 USP47

2.24e-052165231925813
Pubmed

NAAG Peptidase Inhibitors Act via mGluR3: Animal Models of Memory, Alzheimer's, and Ethanol Intoxication.

GRM2 GRM3

2.24e-052165228285415
Pubmed

Genetic variation in the corticotrophin-releasing factor receptors: identification of single-nucleotide polymorphisms and association studies with obesity in UK Caucasians.

CRHR1 CRHR2

2.24e-052165214724656
Pubmed

Localization of transcripts of the related nuclear orphan receptors COUP-TF I and ARP-1 in the adult mouse brain.

NR2F1 NR2F2

2.24e-05216527609634
Pubmed

Cloning of the 1.4-kb mRNA species of human complement factor H reveals a novel member of the short consensus repeat family related to the carboxy terminal of the classical 150-kDa molecule.

CFH CFHR1

2.24e-05216521826708
Pubmed

Pharmacological activation of group-II metabotropic glutamate receptors corrects a schizophrenia-like phenotype induced by prenatal stress in mice.

GRM2 GRM3

2.24e-052165222089319
Pubmed

Regulation of cocaine-induced reinstatement by group II metabotropic glutamate receptors in the ventral tegmental area.

GRM2 GRM3

2.24e-052165221881873
Pubmed

Fractionation of spatial memory in GRM2/3 (mGlu2/mGlu3) double knockout mice reveals a role for group II metabotropic glutamate receptors at the interface between arousal and cognition.

GRM2 GRM3

2.24e-052165221832989
Pubmed

Tumor-conditioned Gr-1(+)CD11b(+) myeloid cells induce angiogenesis through the synergistic action of CCL2 and CXCL16 in vitro.

CXCL16 CCL2

2.24e-052165224388986
Pubmed

Effect of CRHR1 and CRHR2 gene polymorphisms and childhood trauma in suicide attempt.

CRHR1 CRHR2

2.24e-052165230874897
Pubmed

The role of group II metabotropic glutamate receptors in cognition and anxiety: comparative studies in GRM2(-/-), GRM3(-/-) and GRM2/3(-/-) knockout mice.

GRM2 GRM3

2.24e-052165225158312
Pubmed

Metabotropic glutamate receptor 2/3 in the hippocampus of patients with mesial temporal lobe epilepsy, and of rats and mice after pilocarpine-induced status epilepticus.

GRM2 GRM3

2.24e-052165215246118
Pubmed

Metabotropic glutamate receptor 2 and 3 gene expression in the human prefrontal cortex and mesencephalon in schizophrenia.

GRM2 GRM3

2.24e-052165218853337
Pubmed

TET2 binds the androgen receptor and loss is associated with prostate cancer.

TET2 AR

2.24e-052165227819678
Pubmed

Hippocampal mossy fiber long-term depression in Grm2/3 double knockout mice.

GRM2 GRM3

2.24e-052165221360593
Pubmed

Expression of metabotropic glutamate receptor mRNAs in the human spinal cord: implications for selective vulnerability of spinal motor neurons in amyotrophic lateral sclerosis.

GRM1 GRM3

2.24e-052165211535235
Pubmed

A novel nuclear receptor heterodimerization pathway mediated by orphan receptors TR2 and TR4.

NR2C1 NR2C2

2.24e-05216529737983
Pubmed

Activation of metabotropic glutamate receptor type 2/3 supports the involvement of the hippocampal mossy fiber pathway on contextual fear memory consolidation.

GRM2 GRM3

2.24e-052165219638469
Pubmed

Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors.

GRM2 GRM3

2.24e-052165221628565
Pubmed

Expression and subcellular localization of CRH and its receptors in human endometrial cancer.

CRHR1 CRHR2

2.24e-052165219433256
Pubmed

TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3.

NR2C1 AR

2.24e-052165212949936
Pubmed

Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice.

GRM2 GRM3

2.24e-052165224053122
Pubmed

Glial proliferation and metabotropic glutamate receptor expression in amyotrophic lateral sclerosis.

GRM1 GRM2

2.24e-052165215330338
Pubmed

Adaptive Changes in Group 2 Metabotropic Glutamate Receptors Underlie the Deficit in Recognition Memory Induced by Methamphetamine in Mice.

GRM2 GRM3

2.24e-052165238969501
Pubmed

Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction.

GRM2 GRM3

2.24e-052165225583490
Pubmed

Interaction between complement regulators and Streptococcus pyogenes: binding of C4b-binding protein and factor H/factor H-like protein 1 to M18 strains involves two different cell surface molecules.

CFH CFHR1

2.24e-052165215557185
Pubmed

Factor H-related protein 1 neutralizes anti-factor H autoantibodies in autoimmune hemolytic uremic syndrome.

CFH CFHR1

2.24e-052165221677636
Pubmed

An evolutionary conserved COUP-TF binding element in a neural-specific gene and COUP-TF expression patterns support a major role for COUP-TF in neural development.

NR2F1 NR2F2

2.24e-05216527708064
Pubmed

The mGluR2/3 agonist LY379268 induced anti-reinstatement effects in rats exhibiting addiction-like behavior.

GRM2 GRM3

2.24e-052165223624743
Pubmed

Deletion of Metabotropic Glutamate Receptors 2 and 3 (mGlu2 & mGlu3) in Mice Disrupts Sleep and Wheel-Running Activity, and Increases the Sensitivity of the Circadian System to Light.

GRM2 GRM3

2.24e-052165225950516
Pubmed

Association analysis of group II metabotropic glutamate receptor genes (GRM2 and GRM3) with mood disorders and fluvoxamine response in a Japanese population.

GRM2 GRM3

2.24e-052165219386277
Pubmed

The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a pertussis toxin-sensitive G-protein in cultured cerebellar granule cells.

GRM2 GRM3

2.24e-05216527965099
Pubmed

Glutamate receptors and the regulation of steroidogenesis in the human adrenal gland: the metabotropic pathway.

GRM2 GRM3

2.24e-052165224080311
Pubmed

Spatiotemporal expression patterns of chicken ovalbumin upstream promoter-transcription factors in the developing mouse central nervous system: evidence for a role in segmental patterning of the diencephalon.

NR2F1 NR2F2

2.24e-05216528183930
Pubmed

Androgen-androgen receptor system improves chronic inflammatory conditions by suppressing monocyte chemoattractant protein-1 gene expression in adipocytes via transcriptional regulation.

AR CCL2

2.24e-052165227392713
Pubmed

Factor H autoantibodies and deletion of Complement Factor H-Related protein-1 in rheumatic diseases in comparison to atypical hemolytic uremic syndrome.

CFH CFHR1

2.24e-052165222894814
Pubmed

Dynamic expression of COUP-TFI and COUP-TFII during development and functional maturation of the mouse inner ear.

NR2F1 NR2F2

2.24e-052165215907456
Pubmed

ABCC6/MRP6 mutations: further insight into the molecular pathology of pseudoxanthoma elasticum.

ABCA4 ABCC6

2.24e-052165212673275
Pubmed

The highly selective CRF(2) receptor antagonist K41498 binds to presynaptic CRF(2) receptors in rat brain.

CRHR1 CRHR2

2.24e-052165212110614
Pubmed

Distinct distribution of corticotropin releasing factor receptors in human breast cancer.

CRHR1 CRHR2

2.24e-052165220630588
Pubmed

System x(c)- activity and astrocytes are necessary for interleukin-1 beta-mediated hypoxic neuronal injury.

GRM1 IL1R1

2.24e-052165217881516
Pubmed

Activation of both Group I and Group II metabotropic glutamatergic receptors suppress retinogeniculate transmission.

GRM1 GRM2

2.24e-052165223558090
Pubmed

The Transcription Factors COUP-TFI and COUP-TFII have Distinct Roles in Arealisation and GABAergic Interneuron Specification in the Early Human Fetal Telencephalon.

NR2F1 NR2F2

2.24e-052165228922831
Pubmed

Activation of Group II Metabotropic Glutamate Receptors Promotes LTP Induction at Schaffer Collateral-CA1 Pyramidal Cell Synapses by Priming NMDA Receptors.

GRM2 GRM3

2.24e-052165227911756
Pubmed

Reduction of group II metabotropic glutamate receptors during development of benzodiazepine dependence.

GRM2 GRM3

2.24e-052165223392308
Pubmed

Increased binding of cortical and hippocampal group II metabotropic glutamate receptors in isolation-reared mice.

GRM2 GRM3

2.24e-052165220970439
Pubmed

Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos.

PLD2 SOS1

2.24e-052165217486115
Pubmed

Expression of the Abca-subfamily of genes in Abcc6-/- mice--upregulation of Abca4.

ABCA4 ABCC6

2.24e-052165221435020
Pubmed

Behavioural and biochemical responses to methamphetamine are differentially regulated by mGlu2 and mGlu3 metabotropic glutamate receptors in male mice.

GRM2 GRM3

2.24e-052165234217776
Pubmed

Association between corticotropin-releasing hormone receptor 1 and 2 (CRHR1 and CRHR2) gene polymorphisms and personality traits.

CRHR1 CRHR2

2.24e-052165223982282
Pubmed

Corticotropin-releasing hormone receptor expression on normal and tumorous human adrenocortical cells.

CRHR1 CRHR2

2.24e-052165216721033
Pubmed

COUP-TFI and -TFII nuclear receptors are expressed in amacrine cells and play roles in regulating the differentiation of retinal progenitor cells.

NR2F1 NR2F2

2.24e-052165219766631
Pubmed

Group II metabotropic glutamate receptor blockade promotes stress resilience in mice.

GRM2 GRM3

2.24e-052165230939596
Pubmed

Pro-atherogenic effect of interleukin-4 in endothelial cells: modulation of oxidative stress, nitric oxide and monocyte chemoattractant protein-1 expression.

CCL2 IL4

2.24e-052165216249002
Pubmed

Novel NR2F1 variants likely disrupt DNA binding: molecular modeling in two cases, review of published cases, genotype-phenotype correlation, and phenotypic expansion of the Bosch-Boonstra-Schaaf optic atrophy syndrome.

NR2F1 NR2F2

2.24e-052165228963436
Pubmed

The effect of mGlu2/3 receptors on synaptic activities to different types of GABAergic interneurons in the anterior cingulate cortex.

GRM2 GRM3

2.24e-052165232525061
Pubmed

Expression and subcellular distribution of glutamate receptor subunits 2/3 in the developing cerebellar cortex.

GRM2 GRM3

2.24e-05216528838577
Pubmed

Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes.

NR2C1 NR2C2

2.24e-052165222042865
Pubmed

Metabotropic Glutamate Receptor 2/3 Activation Improves Motor Performance and Reduces Pathology in Heterozygous zQ175 Huntington Disease Mice.

GRM2 GRM3

2.24e-052165234330748
Pubmed

A bidirectional regulation between the TR2/TR4 orphan receptors (TR2/TR4) and the ciliary neurotrophic factor (CNTF) signaling pathway.

NR2C1 NR2C2

2.24e-05216529694834
Pubmed

Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis.

GRM2 GRM3

2.24e-052165225434487
Pubmed

mGlu2/3 receptor in the prelimbic cortex is implicated in stress resilience and vulnerability in mice.

GRM2 GRM3

2.24e-052165234090896
Pubmed

Anti-factor H autoantibody-associated hemolytic uremic syndrome: review of literature of the autoimmune form of HUS.

CFH CFHR1

2.24e-052165220865640
Pubmed

A synthetic protein as efficient multitarget regulator against complement over-activation.

CFH CFHR1

2.24e-052165235194132
Pubmed

Complement factor H-related protein 1 deficiency and factor H antibodies in pediatric patients with atypical hemolytic uremic syndrome.

CFH CFHR1

2.24e-052165223243267
Pubmed

Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other.

NR2F6 NR2F1

2.24e-05216522905047
Pubmed

Expression of corticotropin-releasing hormone receptor type 1 and type 2 in human pregnant myometrium.

CRHR1 CRHR2

2.24e-052165217959885
Pubmed

Differential regulation of prostaglandin production mediated by corticotropin-releasing hormone receptor type 1 and type 2 in cultured human placental trophoblasts.

CRHR1 CRHR2

2.24e-052165218325997
Pubmed

Different effects of chronic social defeat on social behavior and the brain CRF system in adult male C57 mice with different susceptibilities.

CRHR1 CRHR2

2.24e-052165232057826
Pubmed

The chicken ovalbumin upstream promoter-transcription factor II negatively regulates the transactivation of androgen receptor in prostate cancer cells.

AR NR2F2

2.24e-052165223145053
Pubmed

Human complement factor H and factor H-like protein 1 are expressed in human retinal pigment epithelial cells.

CFH CFHR1

2.24e-052165224280833
InteractionPI4KAP2 interactions

APPBP2 PI4KAP2 PI4KA

4.85e-0651603int:PI4KAP2
GeneFamilyNuclear hormone receptors

NR2C1 NR2C2 NR2F6 AR NR2F1 NR2F2

7.56e-0749118671
GeneFamilyEF-hand domain containing|Plakins

EVPL DST PLEC

1.48e-0581183939
GeneFamilyGlutamate metabotropic receptors|Protein phosphatase 1 regulatory subunits

GRM1 GRM2 GRM3

1.48e-0581183281
GeneFamilyCorticotropin releasing hormone receptors

CRHR1 CRHR2

4.22e-0521182266
GeneFamilyUbiquitin protein ligase E3 component n-recognins

UBR4 UBR3

8.68e-0471182785
GeneFamilyPHD finger proteins|NuRD complex

MTA1 MTA3

2.67e-031211821305
GeneFamilyATP binding cassette subfamily C

ABCC5 ABCC6

3.14e-03131182807
GeneFamilyChemokine ligands|Endogenous ligands

CXCL16 CCL2 CCL24

3.15e-03451183483
GeneFamilyTrafficking protein particle complex

TRAPPC10 TRAPPC9

3.65e-03141182772
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

MTA1 MTA3

4.20e-0315118282
CoexpressionDESCARTES_FETAL_HEART_SATB2_LRRC7_POSITIVE_CELLS

GPR85 LMO3 PI4KAP2 GRM1 GRM2 GRM3 LRP1B

8.21e-061151647M40201
CoexpressionBLANCO_MELO_COVID19_SARS_COV_2_POS_PATIENT_LUNG_TISSUE_DN

SEMA3F MAF1 RALGDS VPS54 MADD TAF1 SGSM3 SNX11

1.52e-051751648M34029
CoexpressionBROWNE_HCMV_INFECTION_14HR_DN

APPBP2 DTNA SYNE1 ACOX1 DYRK4 DST FSCN2 CCL2 SGSM3 PLEC

1.54e-0529016410M13251
CoexpressionKRAS.DF.V1_DN

PGLYRP4 SYNE1 FANCE URB1 PTPN14 ADRB2 CLDN17 TRAPPC10

3.06e-051931648M2861
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH ADAMTSL1 CPED1 NR2F1 GFRA1 NR2F2 CRACD TRANK1 TANC1

4.80e-08194165981713e0409e8be695ba5dfdc67a997b33435dd9e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH ADAMTSL1 CPED1 NR2F1 GFRA1 NR2F2 CRACD TRANK1 TANC1

4.80e-081941659627cffe2d448e74fc5df92e74e5b922a73304137
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CFH ADAMTSL1 SYNE1 LRRK2 CLSTN2 CPED1 PREX2 GFRA1 PTPRG

6.23e-0820016590c25d56292b9e5fefa4521b72635449be1ffd6fe
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RDH14 UNC13D ELFN2 FBXO47 GFRA1 CRHR1 SPATS2L CCL2

1.33e-071571658beab0ac47202266b04543c02cfcdda012375e879
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NUGGC DOCK11 GRM1 NR2F2 CRHR2 CRACD SPATS2L TANC1

5.92e-071911658de54dab85db70f847de75b3b6d7667a0e13b9bfb
ToppCellBronchial-10x5prime-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CFH CFHR1 CLSTN2 NR2F2 PTPRG CCL2 ECEL1 KCNT1

7.76e-071981658dc6d9032c5029527e184ac13b887c0c1f22ef1c0
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

FNDC3B DTNB VPS54 BIRC6 RABGAP1L UBR3 TRAPPC9 SOS1

8.06e-07199165894b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellTracheal-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CFH SYNE1 LRRK2 CPED1 NR2F1 PREX2 GFRA1 PTPRG

8.37e-072001658b4ccffdd79526c85e5273d27b668dbddcddba1ee
ToppCellfacs-Trachea-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l20-23|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GPR85 GRM2 ELFN2 CRHR1 TRANK1 KNDC1 KCNT1

1.13e-061441657e9d62f202f0fa8747961036ef0eafed91fe8a42f
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Myh8_Etv1_|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GRM1 NR2F2 CRHR2 PPP4R4 TIMELESS ECEL1 MGAT4C

1.36e-0614816574d43efee96a6493abd78e9ca41aab73db0c80626
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Myh8_Etv1_|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GRM1 NR2F2 CRHR2 TIMELESS ECEL1 MGAT4C

1.67e-06971656f3c3fb260954f594a9ab8e1ac9a01115767cbc7a
ToppCellCOVID-19-kidney-PEC|kidney / Disease (COVID-19 only), tissue and cell type

CFH DOCK11 DTNA SYNE1 GFRA1 IL1R1 MGAT4C

3.69e-06172165736a96714a0eb6ac438648135336c9791881ddadb
ToppCellCOVID-19-kidney-Epi_(Mes)|kidney / Disease (COVID-19 only), tissue and cell type

CFH SYNE1 GFRA1 NR2F2 DST IL1R1 MGAT4C

4.80e-061791657e7c9dc63f03d3f3746b51a7e3c8393089e2ceb7d
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FNDC3B ABCA4 WWC3 DTNA PPP4R4 PTPN14 GRIN3B

5.55e-06183165783592c332b1e82673f993d37c7f480befdc3dcda
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4|TCGA-Pancreas / Sample_Type by Project: Shred V9

MYO5A DOCK11 CLSTN2 AR PREX2 PTPRG DSTYK

5.75e-06184165767164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH ADAMTSL1 CPED1 NR2F1 GFRA1 CRACD MGAT4C

5.75e-061841657e061e85c4bb19f49f6451ddd7a9077d7378ee365
ToppCellCOVID-19-kidney-Fibroblast-1|COVID-19 / Disease (COVID-19 only), tissue and cell type

ADAMTSL1 CPED1 NR2F1 GFRA1 NR2F2 CRACD IL1R1

6.40e-06187165776bfe8c42430a230a8bdf299575c444fb7780f24
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CFH CPED1 NR2F1 GFRA1 NR2F2 CRACD TANC1

6.86e-06189165771397e993a77d70b2eeede240bdfc7660b558987
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CFH CPED1 NR2F1 GFRA1 NR2F2 CRACD TANC1

6.86e-0618916574eea4759520c312bd17a681034d8074e47093d2b
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTSL1 SYNE1 CPED1 URB1 CCL2 IL1R1 MGAT4C

7.10e-0619016571121eb607a984c59fbffe7220837fc178745aa55
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTSL1 SYNE1 CPED1 URB1 CCL2 IL1R1 MGAT4C

7.10e-061901657048b581e3f7ea9fc2f87c0532974bba85c7292c2
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH ADAMTSL1 CLSTN2 CPED1 NR2F1 GFRA1 CRACD

7.34e-061911657a6c57627077fa980b7ec1d3894b5f31bfb11b738
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CFH CPED1 NR2F1 GFRA1 NR2F2 CRACD TANC1

7.34e-06191165739092a0aff8097617820c59f5fea9ee2bb4f63a2
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH ADAMTSL1 CLSTN2 CPED1 NR2F1 GFRA1 CRACD

7.34e-0619116578f6d592edc32fdb901af30501d4360512334e8c2
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CFH CPED1 NR2F1 GFRA1 NR2F2 CRACD TANC1

7.34e-061911657ee5f1b1c59029c46cbb1a00935c03b9317bb9da9
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH ADAMTSL1 CPED1 NR2F1 GFRA1 NR2F2 CRACD

7.60e-061921657bc84b9ce01b4d826a682842ab8a395dac9b91183
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH ADAMTSL1 CPED1 NR2F1 GFRA1 NR2F2 CRACD

7.60e-0619216570ab1176cfbb0de8dd1f22c6e2c41265cf6c10ee1
ToppCellCOVID-19-Fibroblasts-Other_FB|COVID-19 / group, cell type (main and fine annotations)

CFH NR2F1 GFRA1 CRACD DST PTPRG IL1R1

7.86e-061931657e6b75be08e33c1de079fb5c02f0b4468128b369c
ToppCell10x5'v1-week_14-16-Endothelial-stroma-proliferating_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

ADAMTSL1 ABCA4 GRM2 F2RL2 NR2F1 PREX2 NR2F2

8.13e-0619416578a4be91414a2e69dd410aa75791f16008204c9a1
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK11 UBR4 LRRK2 CXCL16 CLSTN2 GFRA1 CCL2

8.13e-06194165770185c0b8e0f4e896645b17a243482ba3cdf4a5d
ToppCellCOVID-19-kidney-Fibroblast-2|COVID-19 / Disease (COVID-19 only), tissue and cell type

ADAMTSL1 CPED1 NR2F1 GFRA1 NR2F2 CRACD IL1R1

8.41e-0619516573d62ce1c696f47d4d7eb0c5bb0eec2c24b122bb2
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CFH NR2F1 PTPRG CIBAR1 CCL2 TANC1 IL1R1

8.69e-0619616572ab9735aa7a7e95dcf6b0bdf0427f7b57f6349ee
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH CPED1 NR2F1 GFRA1 NR2F2 CRACD TANC1

8.98e-061971657ae0435f4b4a9cdedb1c201fc56921048390097bf
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH CPED1 NR2F1 GFRA1 NR2F2 CRACD TANC1

8.98e-06197165737f6b6f2809b952382eaebb642b0aad6371f4251
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTSL1 SYNE1 CPED1 NR2F1 PREX2 CCL2 IL1R1

8.98e-0619716579b480f9c799a244bfee64487abd8a1bf07c9a3a2
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTSL1 SYNE1 CPED1 NR2F1 PREX2 CCL2 IL1R1

9.28e-061981657a860246bcea847249a78fd2e86ed8e04371060db
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Esm1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GRM1 ADCY7 NR2F2 CRHR2 ECEL1 MGAT4C

9.51e-0613116563cb4b272e28ee9bad6d874f64a7aae18352a6cfb
ToppCellBronchial-10x5prime-Stromal-Fibroblastic-Fibro_immune_recruiting|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CFH CFHR1 CLSTN2 NR2F1 GFRA1 NR2F2 CRACD

9.59e-0619916570cdbedf09ec72734b86ddab3fec562e066afed92
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH SYNE1 CLSTN2 GFRA1 NR2F2 CCL2 MGAT4C

9.59e-061991657b9338b739162cd8e5661c9a4dcb41a31219b5723
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH SYNE1 CLSTN2 GFRA1 NR2F2 CCL2 MGAT4C

9.59e-061991657c972d3036151403f26fa9d6271520639c281ab84
ToppCellCOVID-19-kidney-Fibroblast-1|kidney / Disease (COVID-19 only), tissue and cell type

CFH CPED1 NR2F1 GFRA1 NR2F2 DST IL1R1

9.59e-0619916579503646ff1ad248181146ce767e9d12e882ec3bd
ToppCellTracheal-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CFH SYNE1 CPED1 NR2F1 PREX2 GFRA1 PTPRG

9.91e-062001657c318d14bd6fd6f42c597eb55ac9e2f48008aeb9b
ToppCellControl_saline-Endothelial-Endothelial-Vein|Control_saline / Treatment groups by lineage, cell group, cell type

SEMA3F FNDC3B LRP1B PREX2 NR2F2 PLEC IL1R1

9.91e-062001657e5f876910bc8cb390d9b46a48d9b6d4d57235551
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CFH SYNE1 CPED1 NR2F1 PREX2 GFRA1 CCL2

9.91e-06200165758b38f9a484ee94191091a0659ed62ebed2d4a14
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c07-AHNAK|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CFH EVPL TMEM121 PPP4R4 SLC5A8 TRBC1

1.83e-0514716565e6dd2ddc67b3722f6528e7277cbc7f296098687
ToppCell10x5'-Liver-Myeloid_Mac-Intestinal_macrophages|Liver / Manually curated celltypes from each tissue

INTU ABCC5 LRP1B DST KNDC1 CCL2

2.56e-0515616569a897fc79c4fae94c5f2e9012d65297f9225e5e3
ToppCellfacs-Marrow-B-cells-24m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH GPR85 CXCL16 CCL2 CCL24 KCNT1

2.66e-0515716560966e347f8d32b13f8a3b3afba3f64637c69cdf9
ToppCellfacs-Marrow-B-cells-24m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH GPR85 CXCL16 CCL2 CCL24 KCNT1

2.66e-0515716566ebfedd91d62c6d4aa8f046657a899a279f82ba2
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTSL1 CPED1 NR2F1 GFRA1 NR2F2 CRACD

2.85e-051591656e812cbde59188924c6277c3feadf1a9592fa62a4
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTSL1 CPED1 NR2F1 GFRA1 NR2F2 CRACD

2.85e-0515916562607b562903228274fbd96168ba826782fab0b53
ToppCellInfluenza_Severe-gd_T|World / Disease group and Cell class

NUGGC SYNE1 ELFN2 PRG2 TRBC2 MGAT4C

3.06e-051611656b3cdaed4d58d57e3c5dbc904a09388f3bf949407
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

CFH TMEM121 PIK3C2G MINAR1 TRBC2 TRBC1

3.39e-0516416568f3255d7f67890389a768453492243ea982eb38a
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

GRM1 ADCY7 CRHR2 ECEL1 FBXO39

3.72e-051011655cf52c93f523c5f25bd45519a1444ce7bd1d8b577
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH ADAMTSL1 CPED1 NR2F1 GFRA1 CRACD

3.88e-051681656d19a115365c5415e51c039718d7669de788fcf33
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA4 DOCK11 LRRK2 CLSTN2 PREX2 PTPN14

4.15e-0517016565d5f208682be21ed58320f5fc083a7898f8712da
ToppCellPND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CLSTN2 NR2F1 PREX2 NR2F2 GRIN3B AJUBA

4.57e-051731656f9d6e892d66f9b94e4d5beb9f5dec9b606bc868a
ToppCellPND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CLSTN2 NR2F1 PREX2 NR2F2 GRIN3B AJUBA

4.57e-051731656cbd65dd5b01cc959e3ccbc89330ddd0122296ea3
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CFH ADAMTSL1 NR2F1 GFRA1 PTPRG TANC1

4.72e-051741656f90ca117b729436cf452e2ddcec26ba525c5c13b
ToppCellfacs-Liver-Non-hepatocytes-3m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO5A DTNA LMO3 ADRB2 RFLNB ECEL1

4.72e-0517416568bdf5a97faf1cf0426d1a8851f8a3e27578f7598
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Degenerative_Ascending_Thin_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA4 DTNA TMEM121 PPP4R4 PTPN14 GRIN3B

4.72e-05174165646bd0ef7d0541386de7a901d85d53d0176dc92bf
ToppCellfacs-Liver-Non-hepatocytes-3m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO5A DTNA LMO3 ADRB2 RFLNB ECEL1

4.72e-051741656fbf998dd33ac27dad7639ea85fca393ba2835307
ToppCellfacs-Trachea-24m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SEMA3F ADAMTSL1 PLEKHG4 NR2F2 PTPN14 DUOXA2

5.03e-051761656460cb302c5b3d609c65b924e1d4e8ea057a68485
ToppCelldroplet-Thymus-nan-21m-Lymphocytic-DN3_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EVPL DYRK4 ELFN2 GFRA1 TMEM121 MTA3

5.03e-051761656d43d9e86c4d4fa1e88fbf2b899ac7143717aac90
ToppCell3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PKD1L3 NR2F1 NR2F2 PTPN14 DST MGAT4C

5.36e-051781656ad3de3e03a401dac64431a541899445262246347
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH ADAMTSL1 CPED1 NR2F1 GFRA1 NR2F2

5.36e-05178165678a0c6340001a77f5b2d890b6263f574af2e72da
ToppCellControl-Epithelial_cells-AT2|Control / group, cell type (main and fine annotations)

SYNE1 LRRK2 LMO3 PPP4R4 PTPRG SLC5A8

5.70e-051801656198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCellMatrixFB-Fibroblast-A|MatrixFB / shred on cell class and cell subclass (v4)

CFH CPED1 PREX2 NR2F2 PPP4R4 SPATS2L

5.70e-051801656adc64ad6033af705dd7b9163a83e20ef5c59f6eb
ToppCellBAL-Control-Epithelial-Epithelial-Basal/Club|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SEMA3F PGLYRP4 EVPL NR2F2 SLC5A8 DUOXA2

5.88e-051811656faff2a34e391d053a17c926540e6cb46d94dd629
ToppCellBAL-Control-Epithelial-Epithelial-Basal/Club-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SEMA3F PGLYRP4 EVPL NR2F2 SLC5A8 DUOXA2

5.88e-0518116565a9c332c0bf07cc20eaf8cf77b45e73668a6467d
ToppCellBAL-Control-Epithelial-Epithelial-Basal/Club-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SEMA3F PGLYRP4 EVPL NR2F2 SLC5A8 DUOXA2

5.88e-051811656488a517f6e5543b648a2e72e0e04332fad776de6
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA4 DOCK11 LRRK2 CLSTN2 PTPN14 PTPRG

5.88e-0518116569d782ba5cf5a172cb4f447763fc50e5b13ef7dd9
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFH NUGGC DTNA CLSTN2 GFRA1 DST

5.88e-051811656b116c68393d8836bac080f81a8fcbeb52e0403e7
ToppCellBAL-Control-Epithelial-Epithelial-Basal/Club|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

SEMA3F PGLYRP4 EVPL NR2F2 SLC5A8 DUOXA2

5.88e-05181165658651853f9c715075889856793df66ebe00c04f1
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CFH DOCK11 DTNA SYNE1 IL1R1 MGAT4C

5.88e-0518116565f2d3a08577c440c944778d07aa993c6e7873f3d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CFH DOCK11 DTNA SYNE1 IL1R1 MGAT4C

5.88e-051811656c7c5f7d4c397b4613c772413a0a679377efffff3
ToppCell10x3'2.3-week_14-16-Endothelial-stroma-proliferating_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

SEMA3F F2RL2 NR2F1 PREX2 NR2F2 SSUH2

6.06e-051821656997d37ca2af661c92a56add888762724dfccc890
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA4 DOCK11 LRRK2 CLSTN2 PTPN14 PTPRG

6.06e-051821656eb138aa1dca9373f1586600f258df06dcf56d81f
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Myh8_Fibin|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADCY7 NR2F2 PPP4R4 MTNR1A MGAT4C

6.37e-051131655feb3c6a7723263d58e5ce020a0097fedfcf78ca8
ToppCelldroplet-Lung-nan-3m-Mesenchymal-fibroblast_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH CFHR1 PREX2 NR2F2 C17orf58 PIK3C2G

6.44e-05184165689ac32e374a4379e4a6c6ea7603b1378b77c147f
ToppCelldroplet-Lung-30m-Mesenchymal-myofibroblast|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DTNA CLSTN2 NR2F1 NR2F2 CRHR2 AJUBA

6.44e-05184165655dde9c4eebac2a33788c1ff1d8fe312d150fad4
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CFH CPED1 NR2F1 GFRA1 CRACD TANC1

6.44e-051841656c5436a8e45f471b8d1301abbe9c7879204537f52
ToppCelldroplet-Lung-30m-Mesenchymal-myofibroblast-pericyte_cell-pericyte|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DTNA CLSTN2 NR2F1 NR2F2 CRHR2 AJUBA

6.44e-0518416567128a2be291544d3df3ed6c80f21ddda8437dcba
ToppCelldroplet-Lung-30m-Mesenchymal-myofibroblast-pericyte_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DTNA CLSTN2 NR2F1 NR2F2 CRHR2 AJUBA

6.44e-051841656d14238f7b0b55a4c8d7040bea854bd221a66ac30
ToppCelldroplet-Lung-nan-3m-Mesenchymal-Alveolar_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH CFHR1 PREX2 NR2F2 C17orf58 PIK3C2G

6.44e-0518416564df6027fa635996c1eddb920f88a5265772df1cd
ToppCellControl-Lymphoid-T_Regulatory|Lymphoid / Disease state, Lineage and Cell class

TET2 IL12RB2 VPS54 SPATS2L TRBC2 IL1R1

6.63e-051851656e481cacda0b6b25f5f0062b962df9a442053ac30
ToppCellIPF-Epithelial-ATII|World / Disease state, Lineage and Cell class

LRRK2 LMO3 RANBP17 PTPRG TANC1 SLC5A8

6.83e-0518616566a4ff2da0af0f5e590d9f9daa5b5e9ac8c868947
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK11 DTNA LRRK2 ABCC6 SPATS2L SLC5A8

6.83e-051861656f28d72b47624b69a580b4429e2be560a26898591
ToppCellILEUM-inflamed-(8)_Fibroblast-(8)_Smooth_muscle_cells|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

DTNA F2RL2 CPED1 PREX2 RFLNB TRBC2

6.83e-051861656cacc2f0b2ed46516173b61ba1c5c226a2db7cddc
ToppCelldroplet-Lung-nan-18m-Myeloid-alveolar_macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RALGDS NR2F6 ACOX1 ABCC5 CRACD DST

7.04e-051871656f0c6e53035b00772377c4d5f761b4d11026b911a
ToppCelldroplet-Lung-nan-18m-Myeloid-Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RALGDS NR2F6 ACOX1 ABCC5 CRACD DST

7.04e-051871656f20e7a1751694390f535ffb27b97e887220f8695
ToppCellControl-Fibroblasts-Other_FB|Control / group, cell type (main and fine annotations)

CFH NR2F1 GFRA1 CRACD DST PTPRG

7.04e-051871656bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH DOCK11 SYNE1 CLSTN2 CCL2 MGAT4C

7.25e-051881656b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCellPCW_13-14-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ADAMTSL1 LRRK2 LMO3 EVPL ABCC6 ADCY7

7.25e-0518816560d86044bc340e3efb90d0022dd299873639d831c
ToppCellCF-Lymphoid-T_cell_&_NK_cell|Lymphoid / Disease state, Lineage and Cell class

IL12RB2 SPATS2L TRBC2 TRBC1 LINC02694 MVB12B

7.25e-05188165615057036b46c9df621ec4955aa94ca3036245d45
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH DOCK11 SYNE1 CLSTN2 CCL2 MGAT4C

7.25e-051881656874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CFH CLSTN2 F2RL2 CPED1 PREX2 IL1R1

7.25e-051881656997dcfc4f08738ab398d8abc15e4fd2fc6619862
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK11 DTNA LRRK2 CLSTN2 AR SPATS2L

7.46e-0518916563b48b0d220cc24d5170713d61fa91f5bb6c21841
ToppCelldroplet-Heart-HEART-1m-Endothelial-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLEKHG4 SSUH2 RFLNB PRDM14 ITPRIPL1 DUOXA2

7.46e-0518916564225bbff4037eecc93a12abad3a38dd04b1e22be
ToppCell10x5'-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like|lymph-node_spleen / Manually curated celltypes from each tissue

CFH ADRB2 DST TANC1 IL1R1 MVB12B

7.68e-0519016560c7eb8f4f2926af01bf44d5c9f239be7b81c67fe
ToppCellMS-CD8-antiviral_CD4|MS / Condition, Cell_class and T cell subcluster

CFH USP18 POLR2B MTA1 SPATS2L ITPRIPL1

7.68e-0519016568c831c4560b8e70f92b4c15644fea39f7f7afcf2
DrugMspg

GRM1 GRM2 GRM3 MTNR1A

1.81e-06131654CID003964410
DrugAC1NSKBB

GRM1 GRM2 GRM3 TAF1

1.81e-06131654CID005311256
DrugCDRI-85/287

NR2C2 NR2F6 AR NR2F1 NR2F2

1.94e-06291655CID000159508
DrugAC1L1EKQ

GRM1 GRM2 GRM3 ADCY7 ADRB2 GRIN3B

2.04e-06521656CID000002834
DrugNPC 12626

GRM1 GRM2 GRM3 AR GRIN3B

2.74e-06311655CID000108099
Drugsodium molybdate

NR2C2 NR2F6 AR NR2F1 NR2F2 PRG2

3.53e-06571656CID000061424
DrugAcamprosate

GRM1 GRM2 GRM3

3.70e-0651653DB00659
Drug1-aminoindan-1,5-dicarboxylic acid

GRM1 GRM2 GRM3 PLD2 GRIN3B

3.79e-06331655CID000002071
Drug3,5-dihydroxyphenylglycine

GRM1 GRM2 GRM3 TAF1 PLD2 GRIN3B

4.79e-06601656CID000108001
Drugmono-(2-ethylhexyl)phthalate

ABCA4 ACOX1 UNC13D AR ABCC6 ADCY7 NR2F2 CRHR2 RANBP17 DST PIK3C2G KNDC1 CCL2 IRS2 TAF1 GRIN3B AJUBA

6.26e-0665816517ctd:C016599
Drug4CPG

GRM1 GRM2 GRM3 TAF1 GRIN3B

7.78e-06381655CID000005115
Drug17alpha-estradiol

NR2C2 NR2F6 ACOX1 ABCC5 GRM1 GRM2 GRM3 LRP1B AR ADCY7 NR2F1 GFRA1 NR2F2 MTA1 MTA3 PTPRG PIK3C2G GUCY2C CCL2 IRS2 PLEC GRIN3B IL1R1 IL4 KCNT1

7.90e-06130316525CID000000450
Drugaminocyclopentane

GRM1 GRM2 GRM3 MTNR1A

9.47e-06191654CID000002906
Drugazetidine-2,4-dicarboxylic acid

GRM1 GRM2 GRM3

1.28e-0571653CID000005370
DrugE-guggulsterone

NR2C2 NR2F6 INTU GPR85 AR NR2F1 NR2F2

1.39e-051081657CID006439929
DrugLisinopril [83915-83-7]; Down 200; 9uM; MCF7; HT_HG-U133A

NR2C1 NR2C2 DTNA ZSCAN9 EVPL URB1 SGSM3 PLD2 KIF1C

1.54e-0519916597403_DN
Drugacamprosate

GRM1 GRM2 GRM3 CRHR1 TIMELESS GRIN3B

1.63e-05741656CID000071158
Drugdopamine

NR2C2 NR2F6 LRRK2 GRM1 GRM2 GRM3 AR ADCY7 NR2F1 GFRA1 NR2F2 ADRB2 GUCY2C MTNR1A TIMELESS PLD2 GRIN3B

1.83e-0571516517CID000000681
Drugcis-MCG-I

GRM1 GRM2 GRM3

2.04e-0581653CID003035584
DrugMSOP

GRM1 GRM2 GRM3 MTNR1A

2.11e-05231654CID003964633
DrugYM90K

GRM1 GRM2 GRM3 GRIN3B

2.11e-05231654CID005486547
DrugImplanon

NR2C2 NR2F6 AR NR2F1 NR2F2

2.26e-05471655CID000040976
DrugCGP 39653

GRM1 GRM2 GRM3 GRIN3B

2.52e-05241654CID006437837
DrugRS)-2-chloro-5-hydroxyphenylglycine

GRM1 GRM2 GRM3 GRIN3B

2.52e-05241654CID003645780
Drugmethylenecyclopropylglycine

GRM1 GRM2 GRM3 TAF1 GRIN3B

2.77e-05491655CID000441452
Drug5,7-dichlorokynurenic acid

INTU GRM1 GRM2 GRM3 GRIN3B

2.77e-05491655CID000001779
Drugplakin

PLEKHG4 SYNE1 EVPL DST PLEC MGAT4C

2.94e-05821656CID000018752
DrugAC1L1D63

GRM1 GRM2 GRM3 TAF1

2.99e-05251654CID000002209
Druggavestinel

GRM1 GRM2 GRM3 GRIN3B

2.99e-05251654CID006450546
DrugmM PEP

GRM1 GRM2 GRM3

3.04e-0591653CID005311462
DrugAC1N21PP

GRM1 GRM2 GRM3

3.04e-0591653CID004014619
Drug1,3-cyclopentanedicarboxylic acid

GRM1 GRM2 GRM3

3.04e-0591653CID000107216
DrugL-CCG-I

GRM1 GRM2 GRM3 TAF1 GRIN3B

3.06e-05501655CID000001271
DrugAC1L9LMC

INTU MYO5A DTNA SYNE1 DST PLEC

3.15e-05831656CID000448113
DrugLY354740

GRM1 GRM2 GRM3 TAF1 GRIN3B

3.38e-05511655CID000114827
DrugAC1NQH9B

GRM1 GRM2 GRM3 GRIN3B

3.51e-05261654CID005221504
DrugN-Ac-D-E

SYNE1 GRM1 GRM2 GRM3 GRIN3B

4.08e-05531655CID000005255
DrugL-689,560

GRM1 GRM2 GRM3 GRIN3B

4.10e-05271654CID000121918
DrugNS-105

GRM1 GRM2 GRM3

4.32e-05101653CID000198695
DrugC-PP

GRM1 GRM2 GRM3 GRIN3B

4.75e-05281654CID000001228
Drugaptiganel

GRM1 GRM2 GRM3 GRIN3B

4.75e-05281654CID000060839
DrugAC1Q6PCP

NR2C2 NR2F6 AR ABCC6 NR2F1 NR2F2 DST CCL2 PLEC

4.79e-052301659CID000005267
DrugCyclopentanes

AR IL4

5.22e-0521652ctd:D003517
Drugphenylalanyl corticotropin-releasing factor (12-41)

CRHR1 CRHR2

5.22e-0521652ctd:C113202
Drugbromoacetylcholamine

DTNA DTNB

5.22e-0521652CID000192097
Drug2-amino-4-phosphonobutyric acid

GRM1 GRM2 GRM3 ADCY7 TAF1 GRIN3B

5.30e-05911656CID000002207
Drugisoxazole

SYNE1 ABCC5 GRM2 GRM3 ECEL1

5.33e-05561655CID000009254
DrugAC1NUW3V

GRM1 GRM2 GRM3 GRIN3B

5.48e-05291654CID005462126
Drugketobemidone

GRM1 GRM2 GRM3 GRIN3B

5.48e-05291654CID000010101
Drugcyclobutylene AP5

GRM1 GRM2 GRM3

5.91e-05111653CID000126582
Drugcis-2,3-piperidine dicarboxylic acid

GRM1 GRM2 GRM3 GRIN3B

6.29e-05301654CID000001226
DrugLY293558

GRM1 GRM2 GRM3 GRIN3B

6.29e-05301654CID000127894
DrugGYKI 53655

GRM1 GRM2 GRM3 GRIN3B

6.29e-05301654CID000126757
DrugAC1L32TU

GRM1 GRM2 GRM3 GRIN3B

6.29e-05301654CID000107831
Drugnitroxyl

IL12RB2 BIRC6 MADD GUCY2C SUPT16H TAF1 GRIN3B IL1R1

6.33e-051851658CID000000945
DrugLY235959

GRM1 GRM2 GRM3 GRIN3B

7.18e-05311654CID000131938
Drugeliprodil

GRM1 GRM2 GRM3 GRIN3B

7.18e-05311654CID000060703
Drugalpha-methyl-4-carboxyphenylglycine

GRM1 GRM2 GRM3 GRIN3B

8.16e-05321654CID000001222
Drugverlukast

ABCC5 AR CCL2 IL4

8.16e-05321654ctd:C059141
Drug6,7-dinitroquinoxaline

GRM3 CRHR1 CRHR2 GRIN3B

9.24e-05331654CID002724608
DrugNitrocaramiphen hydrochloride; Up 200; 10.8uM; MCF7; HT_HG-U133A

DTNA SYNE1 GIT2 AR PREX2 CRHR2 MTA1 DSTYK

9.47e-0519616586504_UP
Drugrosiglitazone; Down 200; 10uM; MCF7; HT_HG-U133A

DNAH3 DTNA WRN GIT2 RANBP17 IRS2 SLC35E3 IL1R1

9.81e-0519716581658_DN
DrugEthisterone [434-03-7]; Up 200; 12.8uM; HL60; HT_HG-U133A

RALGDS PGLYRP4 PPP4R4 GUCY2C DSTYK RABGAP1L IL1R1 TRAPPC9

9.81e-0519716582366_UP
DrugBrompheniramine maleate [980-71-2]; Down 200; 9.2uM; HL60; HT_HG-U133A

NR2F6 SYNE1 ACOX1 DSTYK TRAPPC10 SLC35E3 SGSM3 SOS1

9.81e-0519716581335_DN
DrugCefixime [79350-37-1]; Up 200; 8.8uM; MCF7; HT_HG-U133A

SEMA3F DTNA NR2F1 PPP4R4 URB1 MTA1 IRS2 PLD2

9.81e-0519716583247_UP
DrugKetanserin tartrate hydrate [83846-83-7]; Up 200; 7uM; MCF7; HT_HG-U133A

DTNB EVPL GRM1 NR2F1 CRHR2 URB1 CCL2 TRAPPC9

9.81e-0519716583209_UP
DrugMSOPPE

GRM1 GRM2 GRM3

1.01e-04131653CID005311463
Drugalpha-estradiol; Up 200; 0.01uM; MCF7; HG-U133A

SEMA3F DNAH3 NR2F6 DYRK4 NR2F1 PI4KA TRAPPC10 SNX11

1.02e-041981658762_UP
DrugChlorthalidone [77-36-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A

RALGDS DTNA AR FANCE RABGAP1L TAF1 SGSM3 KIF1C

1.02e-0419816583198_DN
DrugD-CPPene

GRM1 GRM2 GRM3 GRIN3B

1.04e-04341654CID006435801
DrugPF-00562151-00 [351320-12-2]; Down 200; 10uM; MCF7; HT_HG-U133A

GRM2 NR2F1 CRHR2 TRANK1 DSTYK ECEL1 SGSM3 KIF1C

1.05e-0419916585954_DN
DrugOmeprazole [73590-58-6]; Up 200; 11.6uM; PC3; HT_HG-U133A

DTNB CRHR1 CRHR2 CLDN17 CIBAR1 CCL2 SLC35E3 IL1R1

1.09e-0420016586606_UP
Drug(R)-(+)-Atenolol [56715-13-0]; Down 200; 15uM; MCF7; HT_HG-U133A

RALGDS DTNA DSTYK TRAPPC10 TIMELESS IRS2 PLEC SOS1

1.09e-0420016584841_DN
Drugkainite

GRM1 GRM2 GRM3 GRIN3B

1.17e-04351654CID000164810
DrugDR-0

NR2C2 NR2F6 NR2F1 NR2F2

1.17e-04351654CID010062716
DrugMTPG

GRM1 GRM2 GRM3

1.28e-04141653CID005311456
Drug2-methyl-6-styrylpyridine

GRM1 GRM2 GRM3

1.28e-04141653CID000235382
DrugR,S)-AMPA

GRM1 GRM2 GRM3 GRIN3B

1.31e-04361654CID000001221
DrugC6H12NO5P

GRM1 GRM2 GRM3 GRIN3B

1.31e-04361654CID000104962
DrugSistan

CLSTN2 GRM3 WDR11 TAF1

1.31e-04361654CID003001858
Druggacyclidine

GRM1 GRM2 GRM3 GRIN3B

1.31e-04361654CID000176265
Drugglutamic acid diethyl ester

GRM1 GRM2 GRM3 GRIN3B

1.31e-04361654CID000073960
DrugDCG-IV

GRM1 GRM2 GRM3 TAF1 GRIN3B

1.36e-04681655CID000115114
DrugTurbuhaler

CFHR1 ABCC5 ABCC6 ADRB2 CCL24 IL4

1.38e-041081656CID000002462
DrugCompound 10

SYNE1 CLSTN2 GRM2 TMEM121

1.46e-04371654CID003749170
Druganastrozole

AR FANCE MTA1 SUPT16H

1.46e-04371654CID000002187
Drugbenzyloxyaspartate

GRM1 GRM2 GRM3 GRIN3B

1.46e-04371654CID004133412
Drugisospaglumic acid

GRM2 GRM3

1.56e-0431652ctd:C027172
DrugPropionates

GRM1 SLC5A8

1.56e-0431652ctd:D011422
DrugMethacholine Compounds

ADRB2 IL4

1.56e-0431652ctd:D008688
DrugLY 379268

GRM2 GRM3

1.56e-0431652ctd:C118218
DrugP-44

ACOX1 CRHR1 CRHR2

1.60e-04151653CID000200876
Drug1-aminocyclopentane-1,3-dicarboxylate

GRM1 GRM2 GRM3 ADCY7 PLD2 GRIN3B

1.60e-041111656CID000001310
DrugL-BMAA

GRM1 GRM2 GRM3 GRIN3B

1.62e-04381654CID000028558
DrugCGS 19755

GRM1 GRM2 GRM3 GRIN3B

1.62e-04381654CID000068736
DrugAC1L1CBF

RALGDS DTNB ADCY7 CRHR1 CRHR2 FANCE ADRB2 MTNR1A CCL2 SOS1

1.78e-0433616510CID000001822
DrugHA-966

GRM1 GRM2 GRM3 GRIN3B

1.79e-04391654CID000001232
DrugDETC-MeSO

GRM1 GRM2 GRM3 GRIN3B

1.79e-04391654CID003035711
Drugethylglutamate

GRM1 GRM2 GRM3

1.95e-04161653CID000014241
Drug2-PMPA

GRM1 GRM2 GRM3

1.95e-04161653CID010130754
DiseaseEndometrioma

NR2C1 NR2C2 NR2F6 LRRK2 NR2F2 DDX5 MTA1 IL1R1

2.65e-061611588C0269102
DiseaseEndometriosis

NR2C1 NR2C2 NR2F6 LRRK2 NR2F2 DDX5 MTA1 IL1R1

2.65e-061611588C0014175
Diseasetype 2 diabetes mellitus (implicated_via_orthology)

NR2F6 AR NR2F1 NR2F2 MADD IRS2

2.23e-051051586DOID:9352 (implicated_via_orthology)
Diseasealpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C measurement

CFH MGAT4C

2.85e-0521582EFO_0802264
Diseaseanaphase-promoting complex subunit 7 measurement

CFH CFHR1

8.52e-0531582EFO_0801381
DiseaseHEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 1

CFH CFHR1

8.52e-0531582C2749604
DiseaseHEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 1

CFH CFHR1

8.52e-0531582235400
Diseasecalnexin measurement

CFH CFHR1

8.52e-0531582EFO_0801444
DiseaseHemolytic uremic syndrome, atypical, susceptibility to, 1

CFH CFHR1

8.52e-0531582cv:C2749604
Diseasefunctional colonic disease (biomarker_via_orthology)

CRHR1 CRHR2

8.52e-0531582DOID:3877 (biomarker_via_orthology)
DiseaseAddicted to cocaine

GRM2 GRM3

8.52e-0531582C0858355
Diseasecomplement factor H-related protein 4A measurement

CFH CFHR1

8.52e-0531582EFO_0600057
Diseasetubulin polymerization-promoting protein family member 2 measurement

CFH PLEKHG4

8.52e-0531582EFO_0802164
Diseasehistone-lysine N-methyltransferase 2D measurement

CFH CFHR1

8.52e-0531582EFO_0801683
DiseaseColorectal Carcinoma

TET2 RALGDS DNAH3 ABCA4 SYNE1 WRN ABCC5 CLSTN2 GRM1 ABCC6 PREX2 GUCY2C PRG2

1.10e-0470215813C0009402
DiseaseAge-related macular degeneration

CFH CFHR1 ABCA4

1.16e-04181583cv:C0242383
DiseaseNADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial measurement

CFH CFHR1

1.70e-0441582EFO_0803292
DiseaseC-C motif chemokine 24 measurement

CFH CCL24

1.70e-0441582EFO_0020197
Diseasekallikrein-5 measurement

CFH CFHR1

1.70e-0441582EFO_0020515
DiseasePneumonitis

CCL2 CCL24 IL1R1 IL4

2.03e-04541584C3714636
DiseasePneumonia

CCL2 CCL24 IL1R1 IL4

2.03e-04541584C0032285
DiseaseLobar Pneumonia

CCL2 CCL24 IL1R1 IL4

2.03e-04541584C0032300
DiseaseExperimental Lung Inflammation

CCL2 CCL24 IL1R1 IL4

2.03e-04541584C0887898
Diseaseasthma (is_implicated_in)

CRHR1 CRHR2 ADRB2 CCL2 CCL24 IL4

2.08e-041571586DOID:2841 (is_implicated_in)
DiseaseEpilepsy, Benign Psychomotor, Childhood

GRM1 GRM2 GRM3

2.47e-04231583C0393672
DiseaseEpilepsy, Lateral Temporal

GRM1 GRM2 GRM3

2.47e-04231583C0393682
DiseaseUncinate Epilepsy

GRM1 GRM2 GRM3

2.47e-04231583C0014558
DiseaseEpilepsy, Temporal Lobe

GRM1 GRM2 GRM3

2.47e-04231583C0014556
DiseaseMood Disorders

GRM3 AR ADCY7 CRHR1 CRHR2 TIMELESS

3.00e-041681586C0525045
DiseaseInsulin Sensitivity

AR ADRB2 CCL2 IRS2

3.06e-04601584C0920563
DiseaseInsulin Resistance

AR ADRB2 CCL2 IRS2

3.06e-04601584C0021655
Diseasebrain connectivity measurement

SEMA3F RDH14 CPED1 C17orf58 PLEC LINC02694 MOB4 TANGO6 SOS1

3.21e-044001589EFO_0005210
DiseaseCOVID-19 (is_marker_for)

CXCL16 CCL2 IL1R1 IL4

3.69e-04631584DOID:0080600 (is_marker_for)
DiseaseAllergic Reaction

CCL2 CCL24 IL1R1 IL4

3.69e-04631584C1527304
DiseaseHypersensitivity

CCL2 CCL24 IL1R1 IL4

3.92e-04641584C0020517
DiseaseMembranoproliferative Glomerulonephritis, Type II

CFH CFHR1

4.21e-0461582C0268743
Diseasecomplement C1s subcomponent measurement

CFH CFHR1

4.21e-0461582EFO_0008091
Diseaseglial fibrillary acidic protein measurement

CFH PRG2

4.21e-0461582EFO_0020404
Diseasenon-alcoholic fatty liver disease severity measurement

PTPRG LINC02694 TRAPPC9

4.47e-04281583EFO_0008421
DiseaseAge related macular degeneration

CFH CFHR1 ABCA4

5.50e-04301583C0242383
Diseaseepidermolysis bullosa simplex (is_implicated_in)

DST PLEC

5.88e-0471582DOID:4644 (is_implicated_in)
DiseaseAlcoholic Intoxication, Chronic

GRM1 GRM2 GRM3 AR ADCY7 CRHR1 LINC02694

6.27e-042681587C0001973
Diseaseanterior uveitis (is_implicated_in)

CFH CCL2

7.81e-0481582DOID:1407 (is_implicated_in)
Diseasehepatitis A virus cellular receptor 2 measurement

CFH ABCC6

7.81e-0481582EFO_0008151
Diseaseirritable bowel syndrome (biomarker_via_orthology)

CRHR1 CRHR2

7.81e-0481582DOID:9778 (biomarker_via_orthology)
DiseaseLeishmaniasis, Cutaneous

CCL2 IL4

7.81e-0481582C0023283
Diseasesphingomyelin 16:1 measurement

RALGDS NKX1-1

7.81e-0481582EFO_0010392
DiseaseUrban cutaneous leishmaniasis

CCL2 IL4

7.81e-0481582C0086541
DiseaseLeishmaniasis, New World

CCL2 IL4

7.81e-0481582C0086540
Diseasegdnf family receptor alpha-1 measurement

CFH GFRA1

7.81e-0481582EFO_0020400
Diseaseatypical hemolytic-uremic syndrome (is_implicated_in)

CFH CFHR1

7.81e-0481582DOID:0080301 (is_implicated_in)
Diseasekidney disease

CFH HORMAD2

7.81e-0481582EFO_0003086
DiseaseAtypical hemolytic-uremic syndrome

CFH CFHR1

1.00e-0391582cv:C2931788
DiseaseC3 glomerulopathy

CFH CFHR1

1.00e-0391582C4087273
DiseaseHemolytic-uremic syndrome

CFH CFHR1

1.00e-0391582cv:C0019061
Diseaseleukocyte immunoglobulin-like receptor subfamily A member 5 measurement

CFH CFHR1

1.00e-0391582EFO_0801766
Diseasevital capacity

CFH TET2 HORMAD2 ADAMTSL1 SYNE1 POLR2B ZNF629 RDH14 UNC13D PKD1L3 DDX5 FANCE ADRB2 DST LINC02694 IL1R1

1.01e-03123615816EFO_0004312
Diseasesex interaction measurement, Crohn's disease

LRRK2 CCL2 LINC02694

1.02e-03371583EFO_0000384, EFO_0008343
Diseasemean platelet volume

SEMA3F TET2 MYO5A DOCK11 ACOX1 LRRK2 ABCC5 UNC13D TRANK1 PI4KA DSTYK EPC1 IRS2 PLEC

1.22e-03102015814EFO_0004584
DiseaseAtypical Hemolytic Uremic Syndrome

CFH CFHR1

1.25e-03101582C2931788
Diseasemembranoproliferative glomerulonephritis (implicated_via_orthology)

CFH CCL2

1.25e-03101582DOID:2920 (implicated_via_orthology)
Diseaseabdominal obesity-metabolic syndrome (implicated_via_orthology)

DDX5 GUCY2C

1.25e-03101582DOID:0060611 (implicated_via_orthology)
DiseaseFuchs endothelial corneal dystrophy

CFH PTPRG

1.25e-03101582Orphanet_98974
DiseasePleural Diseases

CCL2 IL4

1.25e-03101582C0032226
Diseasechronic obstructive pulmonary disease

TET2 FNDC3B ADAMTSL1 ZSCAN9 VPS54 ARMC2 PPP4R4 SPATS2L ADRB2 DSTYK EPC1

1.25e-0368815811EFO_0000341
Diseasewhite matter microstructure measurement

ZSCAN9 ABCC5 UNC13D CPED1 C17orf58 PLEC LINC02694 SOS1

1.25e-033901588EFO_0005674
Diseasetestosterone measurement

TET2 HORMAD2 NR2F6 MYO5A ZNF629 UNC13D BIRC6 AR URB1 PTPRG WDR11 KNDC1 YY1AP1 MINAR1 PLEKHM3 SOS1

1.40e-03127515816EFO_0004908
Diseasehemopexin measurement

CFH CFHR1

1.52e-03111582EFO_0008149
Diseasepsoriasis (is_marker_for)

CFH ADRB2 IL4

1.70e-03441583DOID:8893 (is_marker_for)
Diseasefibrinogen measurement, tissue plasminogen activator measurement

PKD1L3 PLEC IL1R1

1.81e-03451583EFO_0004623, EFO_0004791
Diseasefibrinogen measurement, plasminogen activator inhibitor 1 measurement

PKD1L3 PLEC IL1R1

1.81e-03451583EFO_0004623, EFO_0004792
Diseaserhinitis (is_marker_for)

CRHR1 CRHR2 CCL24

1.93e-03461583DOID:4483 (is_marker_for)
Diseasehemoglobin A1 measurement

TET2 FNDC3B UNC13D CRHR2 MADD SLC22A16 IRS2 LINC02694 KIF1C

2.03e-035201589EFO_0007629
Diseasecalcium measurement

CFH TET2 LRP1B ABCC6 TMEM121 PPP4R4 IRS2 PLEC MVB12B SOS1

2.13e-0362815810EFO_0004838
DiseaseN-acetyl-isoputreanine measurement

SPATS2L KIF1C

2.14e-03131582EFO_0800107
Diseaserisky sexual behaviour measurement

TET2 PKD1L3 BIRC6 C17orf58 CLDN17

2.21e-031691585EFO_0007877
Diseasechromosome 22q11.2 deletion syndrome, distal (implicated_via_orthology)

PI4KAP2 PI4KA

2.49e-03141582DOID:0060413 (implicated_via_orthology)
Diseaseanti-basement membrane glomerulonephritis (implicated_via_orthology)

CCL2 IL4

2.49e-03141582DOID:4780 (implicated_via_orthology)
DiseaseMental Depression

GRM1 AR ADCY7 CRHR1 CRHR2 TIMELESS

2.54e-032541586C0011570
Diseasefibrinogen measurement

PKD1L3 WDR11 PLEC IL1R1

2.85e-031091584EFO_0004623
DiseaseUveal Melanoma

ADAMTSL1 LRP1B GFRA1

2.90e-03531583EFO_1000616
Diseasesystemic scleroderma (is_marker_for)

CXCL16 CCL2 IL4

2.90e-03531583DOID:418 (is_marker_for)
Diseaseinflammatory bowel disease

TET2 HORMAD2 IL12RB2 UBR4 LRRK2 ADCY7 CCL2 LINC02694

2.99e-034491588EFO_0003767
Diseasepneumonia, COVID-19

ADAMTSL1 LRP1B MTNR1A TRAPPC9

3.24e-031131584EFO_0003106, MONDO_0100096
Diseasecathepsin L1 measurement

LRRK2 GRM1

3.25e-03161582EFO_0010619
Diseasetemporal arteritis (is_implicated_in)

CCL2 IL4

3.25e-03161582DOID:13375 (is_implicated_in)
Diseasedual specificity mitogen-activated protein kinase kinase 2 measurement

CFH PPP4R4

3.25e-03161582EFO_0008112
Diseasefactor XI measurement, fibrinogen measurement, tissue plasminogen activator measurement, factor VII measurement

PKD1L3 PLEC IL1R1

3.39e-03561583EFO_0004619, EFO_0004623, EFO_0004694, EFO_0004791
Diseaseforced expiratory volume

TET2 HORMAD2 ADAMTSL1 SYNE1 ZNF629 RDH14 ARMC2 SPATS2L ADRB2 DST WDR11

3.60e-0378915811EFO_0004314
Diseaseresponse to phenylephrine

CLSTN2 F2RL2

3.68e-03171582EFO_0010152
DiseaseAutoimmune Chronic Hepatitis

CCL2 IL4

3.68e-03171582C0241910
Diseasesystemic lupus erythematosus, COVID-19

IL12RB2 ZSCAN9 CRHR1

3.75e-03581583MONDO_0007915, MONDO_0100096
Diseasefibrinogen measurement, factor VII measurement

PKD1L3 PLEC IL1R1

3.75e-03581583EFO_0004619, EFO_0004623
DiseaseColorectal Neoplasms

TET2 ABCA4 SYNE1 ABCC5 ABCC6 GUCY2C

3.88e-032771586C0009404
Diseaselupus nephritis (is_implicated_in)

CFH CCL2

4.12e-03181582DOID:0080162 (is_implicated_in)
DiseaseAnorexia

CRHR1 CRHR2

4.12e-03181582C0003123
Diseasefree androgen index

TET2 NR2F6 AR URB1 PTPRG WDR11 MINAR1

4.14e-033741587EFO_0007005
Diseasepain

HORMAD2 PKD1L3 CRHR1 RABGAP1L IL1R1

4.17e-031961585EFO_0003843
DiseaseBipolar Disorder

SYNE1 GRM3 CRHR1 CRHR2 TRANK1 ADRB2 TIMELESS LINC02694

4.30e-034771588C0005586
Diseaseglucose measurement

TET2 HORMAD2 ARMC2 MADD ADRB2 PIK3C2G USP47

4.51e-033801587EFO_0004468

Protein segments in the cluster

PeptideGeneStartEntry
HACYTVRRFSIRNTK

PTPRG

986

P23470
CRKLYRSINRTGTAQ

EPC1

546

Q9H2F5
FQELLCLRRSSLKAY

ADRB2

336

P07550
RVVSYQLSSRSTCLK

CCL24

46

O00175
KTCVDTYTNRLRSKR

BIRC6

4441

Q9NR09
ICLFYQTLTLRGSRK

CPED1

26

A4D0V7
FSQRRGAKTVRYALC

ABCA4

216

P78363
RTLRCKAFYSVNGSV

AJUBA

371

Q96IF1
CTNIARIFSKLTSYR

ARMC2

491

Q8NEN0
FKSYRTIFSCLNRIK

COQ3

61

Q9NZJ6
CYSALLTKTNRIARI

GRM2

646

Q14416
YSALLTKTNCIARIF

GRM3

656

Q14832
SYRLNKICSGLSFQR

BRPF3

481

Q9ULD4
FILTAALSYVLCKRR

CXCL16

216

Q9H2A7
RLLTSSAYRLQSECK

GIT2

701

Q14161
VKVASVLAYSFSRRC

APPBP2

91

Q92624
SVEFVCKRGYRLSSR

CFH

1196

P08603
RDLFTYTVKCIQIRR

ADCY7

206

P51828
SEITYCRRNFLNRTS

DHX29

1156

Q7Z478
RFRIKCSELNGRYTS

CLSTN2

766

Q9H4D0
RQARVRLQCKFYSSL

CLDN17

56

P56750
FRCRTTFYTALTRLL

RANBP17

661

Q9H2T7
RNSRRSKGIAYVEFC

RBM23

201

Q86U06
FFKRSIRKNLVYSCR

NR2C1

136

P13056
CKSFFKRSIRRNLSY

NR2F6

76

P10588
KRSIRRNLSYTCRSN

NR2F6

81

P10588
FKRSVRKNLTYSCRS

NR2C2

141

P49116
CKSFFKRSVRRNLTY

NR2F1

106

P10589
KRSVRRNLTYTCRAN

NR2F1

111

P10589
SFFKRSVRRNLSYTC

NR2F2

101

P24468
YTLSCRDRNEKIFRV

GUCY2C

681

P25092
VSRQCLLTLIRKYDF

PIK3C2G

401

O75747
KQRRQCSTYLRLGEF

MGAT4C

421

Q9UBM8
LLSSSYKTRTCRCRT

LRP1B

491

Q9NZR2
FSTFRECLYTLKRLV

MADD

186

Q8WXG6
YNKRLKRIVFFSCRS

MAF1

191

Q9H063
ATDRFRSLYSKCNVL

DST

4021

Q03001
KKLFATSISCITYLR

HORMAD2

36

Q8N7B1
LLRSSSSYVKRFNRK

C17orf58

311

Q2M2W7
RIKFQKASVSRCTLY

IL12RB2

231

Q99665
RTYGRLFQKLCSSSA

KCNT1

1001

Q5JUK3
FLECGKTNLRRTTYL

DDX5

231

P17844
LSSKSCEGRNIRYRT

ADAMTSL1

61

Q8N6G6
IIFSVRYRAASRSSK

OR4K13

221

Q8NH42
VRDIQSFYIDRLKSC

PGLYRP4

256

Q96LB8
QYSIEAALRCRRISK

EVPL

1746

Q92817
ERQCALRVFKARIYT

FBXO39

391

Q8N4B4
TYSTERLRKCLFLFI

CRHR2

216

Q13324
KVIQSCFLSNRSRTY

PI4KA

2076

P42356
LSTLRYADRTKQIRC

KIF1C

336

O43896
GSTLYTKANLILCRR

LMO3

51

Q8TAP4
TRRLIRVIYNFCNSV

LRRK2

2441

Q5S007
RCQLEVKLNTSRTFY

GARIN5A

196

Q6IPT2
TSCSRRFYQLTKLLD

AR

851

P10275
QRLKSLRAYLFSCRA

PLEKHM3

606

Q6ZWE6
ESCKLRRLRFTYGTQ

DSTYK

146

Q6XUX3
TEASYSRFLRKAECI

ECEL1

636

O95672
TRYLCFTRSFSKENS

MVB12B

91

Q9H7P6
SRILYSFCTAFKRSS

RABGAP1L

241

Q5R372
FRTRSICTTVFYTNL

F2RL2

121

O00254
TCRRTLFGDYSLKTR

INTU

691

Q9ULD6
LGNLTVIYTFCRSRS

OPN4

86

Q9UHM6
TCRYLLVRSLQTFSQ

PRG2

106

P13727
KNLTGVYRLCLSART

IRS2

211

Q9Y4H2
STTSCKLRLDYRSGR

ITPRIPL1

346

Q6GPH6
ASRLTAYFRRKCVAA

ABCC5

336

O15440
KFTSIRRVRGDNYCA

OTULIN

116

Q96BN8
LKTYDTSFLDFLRRC

DYRK4

366

Q9NR20
SYKAFSAARVTARVR

DUOXA2

86

Q1HG44
RALSKACTIAIRYSA

ACOX1

291

Q15067
FQAATYLCLLRSIRK

FMC1

61

Q96HJ9
KETFCRAATVLRQFY

IL4

66

P05112
VYSRRCVSFILRATV

HEATR5B

351

Q9P2D3
RNVNYSLASFLKRCL

DOCK11

1021

Q5JSL3
CQIFAAYVRKTARLR

CIBAR1

31

A1XBS5
RSLAQKIVATYRLCS

DNAH3

1576

Q8TD57
KTNYICRSRLADFFT

GFRA1

251

P56159
QRLASYRRITSSKCP

CCL2

46

P13500
KVQRLTEFTCYSFRI

FNDC3B

1016

Q53EP0
GIKLRRTNYSLRFNC

CRACD

846

Q6ZU35
NFDVIRLSTYRTACK

DTNB

26

O60941
RLSTYRTACKLRFVQ

DTNB

31

O60941
FYCFLNSEVRSAIRK

CRHR1

391

P34998
RECRILKNFSSLYAI

RALGDS

471

Q12967
RLSTYRTACKLRFVQ

DTNA

31

Q9Y4J8
KLRRSNRQTSCYSKT

FBXO47

16

Q5MNV8
LRRCFSTTLLYCRKS

GPR85

346

P60893
TFTKIYRRSLCVLQA

KNDC1

1311

Q76NI1
RLLTTALTSFCAKYT

FANCE

381

Q9HB96
AEFVCKRGYRLSSRS

CFHR1

296

Q03591
CYSALVTKTNRIARI

GRM1

671

Q13255
CSNISFYLILKARRV

UTP3

276

Q9NQZ2
CVVRNSSYCLRIKIS

IL1R1

96

P14778
RFLCIAFSYIRILTT

OR1L8

211

Q8NGR8
SQLAKLRSVLFYTAC

MINAR1

41

Q9UPX6
TLIFRSRRYCLKSCD

FSCN2

176

O14926
KVVCFYRRRDISNTL

MTA3

41

Q9BTC8
NLCYAILFRRTVSSK

GRIN3B

621

O60391
RQCTFRTFTRIFSAK

HSFX1

166

Q9UBD0
RLKLATGRTFYLQLC

GARIN3

141

Q8TC56
SKTTRFCLICNYVSR

RFC4

171

P35249
SKAFTAKTSCVRRRY

SNX11

46

Q9Y5W9
TSYRCILRACLVRSK

NUGGC

526

Q68CJ6
ASRTLCIFLRYNRKQ

PPP4R4

546

Q6NUP7
QACSRYTASSKRRSR

SEMA3F

571

Q13275
SSVAKLGSVCRRIYR

MOB4

151

Q9Y3A3
CVYCTKRFTASSILR

PRDM14

491

Q9GZV8
KDLQRCTVSLTRYRV

SPATS2L

226

Q9NUQ6
LCRFSRDLSTYSGKV

SYNE1

3026

Q8NF91
KATRYLSVCERLNLA

NKX1-1

316

Q15270
KFRATRYLSVCERLN

NKX1-2

181

Q9UD57
FQSLYVVSSCQLRRL

ABCC6

1101

O95255
VNYVLKCREVRSRAS

PLEKHG4

1066

Q58EX7
TLDYNCRKTLRRFLS

RFLNB

181

Q8N5W9
KVGRRTVLAYSLFCS

SLC22A16

411

Q86VW1
LNSSATGRCLKIYRT

TAF1

1156

P21675
RRYNVLSKNCFVTRI

PTPN14

11

Q15678
SCTYLSRNFIRISSK

PKD1L3

111

Q7Z443
SVYSRLVLCKTFRLD

SGSM3

606

Q96HU1
RYTKRDCSTFLRTSE

POLR2B

886

P30876
RYISCKSRFQAKLSL

SLC5A8

266

Q8N695
VSLYLNLSRCRRKTN

TANC1

1336

Q9C0D5
KYLHSSRCRRQIILS

WRN

901

Q14191
CYSRSKLANILFTRE

RDH14

216

Q9HBH5
KVVCFYRRRDISSTL

MTA1

41

Q13330
KVIQSCFLSNRSRTY

PI4KAP2

566

A4QPH2
AKRRLSESACRFYSQ

SOS1

396

Q07889
GIRFKSYCSNLVRTL

SUPT16H

276

Q9Y5B9
KDSAVRSSIFRLYSR

URB1

2141

O60287
LKRQTLCRYRLETFS

SSUH2

106

Q9Y2M2
LCRYRLETFSESRIS

SSUH2

111

Q9Y2M2
IRRALRDYKQVTASC

ABTB1

81

Q969K4
RVCIYRRRTNSTTTK

CLDN34

56

H7C241
YLGKSTRRRACQSLL

LINC02694

151

Q8NAA6
FLDYLKRFACSTVVR

TIMELESS

691

Q9UNS1
KRFACSTVVRAYVLL

TIMELESS

696

Q9UNS1
SRYCLSSRLRVSATF

TRBC1

71

P01850
KYASRSCVFRSTVQR

STPG4

151

Q8N801
ALATKACTFLEYRRQ

TMEM121

256

Q9BTD3
RCYNDLRLLSVSSKT

USP47

766

Q96K76
ATRRLYTSCKALLNV

TANGO6

191

Q9C0B7
FFSKIYQTEELRSCR

TEX10

526

Q9NXF1
LCQRISSYKKFSRVL

PREX2

896

Q70Z35
ALRRKYSCDRSATVT

PLEC

881

Q15149
YLLTCKTARQLTVRI

YY1AP1

311

Q9H869
IRNSQTRKICHSLYF

USP41

261

Q3LFD5
RLSLLQRYFKDSSCL

UBR3

1296

Q6ZT12
RYCTEGKRTFSSRLI

ZNF687

1026

Q8N1G0
FFRIYKRICSVSQIS

TRAPPC9

31

Q96Q05
SRYCLSSRLRVSATF

TRBC2

71

A0A5B9
IRNSQTRKICHSLYF

USP18

261

Q9UMW8
SQCSKSYSRRSFLIE

ZSCAN9

341

O15535
LRSYLFSRQCTLLLF

TRAPPC10

306

P48553
RLCQITRSLLGKTYR

TRANK1

2131

O15050
CITLRVRRSYNNIFT

WDR11

311

Q9BZH6
SQRRGLLSSKTYICS

ZNF629

651

Q9UEG4
TLLSTSYRKACVLQR

UBR4

536

Q5T4S7
NECSKTFRLRSYLAS

ZNF600

501

Q6ZNG1
TLRKYGTLTNRRCAL

TET2

1251

Q6N021
HRSLILKCSSYRQAR

PLD2

286

O14939
KLTLRATYDNCTRRV

ZP2

96

Q05996
ASSRELIRKYFCSRI

UNC13D

886

Q70J99
CYQKTFSTRIQLTLI

SLC35E3

121

Q7Z769
RTLRYKQSCRSSLAE

WWC3

946

Q9ULE0
TRLSDLLKYFNSRSC

VPS54

771

Q9P1Q0
TQCRKAFRSVKYLRV

ZNF878

286

C9JN71
IRQCILTRDSSIFKY

ZNF114

146

Q8NC26
EYTFCVTSLRNSRRF

ELFN2

356

Q5R3F8
NFRKEYRRIIVSLCT

MTNR1A

301

P48039
RQYVLCTLSRITTFD

LRRC51

146

Q96E66
RCYAKFLRRTKAATI

MYO5A

806

Q9Y4I1