Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	benzodiazepine receptor binding	RIMBP3 RIMBP3C RIMBP3B	1.47e-07	5	50	3	GO:0030156
GeneOntologyMolecularFunction	potassium:chloride symporter activity	SLC12A1 SLC12A9	2.19e-04	9	50	2	GO:0015379
GeneOntologyMolecularFunction	water channel activity	AQP12A AQP12B	8.16e-04	17	50	2	GO:0015250
GeneOntologyMolecularFunction	water transmembrane transporter activity	AQP12A AQP12B	1.13e-03	20	50	2	GO:0005372
GeneOntologyMolecularFunction	chloride:monoatomic cation symporter activity	SLC12A1 SLC12A9	1.50e-03	23	50	2	GO:0015377
GeneOntologyMolecularFunction	monoatomic anion:monoatomic cation symporter activity	SLC12A1 SLC12A9	1.92e-03	26	50	2	GO:0015296
GeneOntologyBiologicalProcess	chloride ion homeostasis	BSND SLC12A1 SLC12A9	2.79e-05	25	49	3	GO:0055064
GeneOntologyBiologicalProcess	monoatomic anion homeostasis	BSND SLC12A1 SLC12A9	3.96e-05	28	49	3	GO:0055081
GeneOntologyBiologicalProcess	neuromuscular synaptic transmission	RIMBP3 RIMBP3C RIMBP3B	8.51e-05	36	49	3	GO:0007274
GeneOntologyBiologicalProcess	potassium ion homeostasis	BSND SLC12A1 SLC12A9	9.25e-05	37	49	3	GO:0055075
GeneOntologyCellularComponent	manchette	RIMBP3 RIMBP3C RIMBP3B	4.55e-05	28	52	3	GO:0002177
MousePheno	abnormal urine sodium level	BSND SLC12A1 ABCG2 AKR1B1	1.18e-05	51	39	4	MP:0006274
MousePheno	ectopic manchette	RIMBP3 RIMBP3C RIMBP3B	1.89e-05	19	39	3	MP:0009377
MousePheno	abnormal bile color	ABCG2 SIK3	2.27e-05	3	39	2	MP:0000341
MousePheno	detached sperm flagellum	RIMBP3 RIMBP3C RIMBP3B	2.58e-05	21	39	3	MP:0008893
MousePheno	abnormal urine osmolality	BSND SLC12A1 ABCG2 AKR1B1	3.10e-05	65	39	4	MP:0002987
MousePheno	decreased urine sodium level	BSND SLC12A1 AKR1B1	6.98e-05	29	39	3	MP:0006317
MousePheno	abnormal renal water reabsorption	SLC12A1 AKR1B1	1.13e-04	6	39	2	MP:0010108
MousePheno	alkalosis	BSND SLC12A1	1.58e-04	7	39	2	MP:0003028
MousePheno	abnormal potassium level	BSND SLC12A1 ABCG2 SIK3 AKR1B1	2.01e-04	196	39	5	MP:0020887
MousePheno	abnormal potassium ion homeostasis	BSND SLC12A1 ABCG2 SIK3 AKR1B1	2.11e-04	198	39	5	MP:0011978
MousePheno	detached acrosome	RIMBP3 RIMBP3C RIMBP3B	2.46e-04	44	39	3	MP:0009231
MousePheno	impaired fertilization	RIMBP3 DNHD1 RIMBP3C APOB RIMBP3B	2.54e-04	206	39	5	MP:0000242
MousePheno	abnormal manchette morphology	RIMBP3 RIMBP3C RIMBP3B	2.63e-04	45	39	3	MP:0009376
MousePheno	abnormal renal water transport	SLC12A1 AKR1B1	2.70e-04	9	39	2	MP:0011443
MousePheno	decreased male germ cell number	RIMBP3 DNHD1 BRCA1 ADGRG1 RIMBP3C APOB RIMBP3B STAG3	3.22e-04	640	39	8	MP:0004901
MousePheno	increased hormone level	BSND RALGAPA1 SLC12A1 PRDX3 DBH ABCG2 SIK3 CBS	3.26e-04	641	39	8	MP:0014454
MousePheno	abnormal renal water homeostasis	SLC12A1 AKR1B1	3.37e-04	10	39	2	MP:0011444
MousePheno	abnormal fertilization	RIMBP3 DNHD1 RIMBP3C APOB RIMBP3B	3.51e-04	221	39	5	MP:0005410
MousePheno	increased cholesterol level	RALGAPA1 AQP12A PRDX3 APOB ABCG2 SIK3 AQP12B	4.18e-04	502	39	7	MP:0003982
MousePheno	increased sterol level	RALGAPA1 AQP12A PRDX3 APOB ABCG2 SIK3 AQP12B	4.34e-04	505	39	7	MP:0012226
MousePheno	decreased urine osmolality	BSND SLC12A1 AKR1B1	4.51e-04	54	39	3	MP:0002988
MousePheno	kinked sperm flagellum	RIMBP3 RIMBP3C RIMBP3B	5.02e-04	56	39	3	MP:0009237
MousePheno	decreased germ cell number	RIMBP3 DNHD1 BRCA1 ADGRG1 RIMBP3C APOB RIMBP3B STAG3	5.18e-04	687	39	8	MP:0002209
MousePheno	abnormal sodium level	BSND SLC12A1 ABCG2 SIK3 AKR1B1	5.21e-04	241	39	5	MP:0020889
MousePheno	abnormal sodium ion homeostasis	BSND SLC12A1 ABCG2 SIK3 AKR1B1	5.72e-04	246	39	5	MP:0011977
MousePheno	abnormal urine urea nitrogen level	SLC12A1 AKR1B1	5.80e-04	13	39	2	MP:0011465
MousePheno	increased urine osmolality	SLC12A1 ABCG2	6.76e-04	14	39	2	MP:0008055
MousePheno	increased susceptibility to induced pancreatitis	AQP12A AQP12B	7.78e-04	15	39	2	MP:0004761
Domain	Aquaporin_12	AQP12A AQP12B	7.31e-06	2	51	2	IPR023265
Domain	CXorf40	EOLA2 EOLA1	7.31e-06	2	51	2	IPR033615
Domain	Aquaporin_11/12	AQP12A AQP12B	2.19e-05	3	51	2	IPR016697
Domain	ASCH_domain	EOLA2 EOLA1	2.19e-05	3	51	2	IPR007374
Domain	ASCH	EOLA2 EOLA1	2.19e-05	3	51	2	SM01022
Domain	TLV_coat	ERVV-2 ERVV-1	1.52e-04	7	51	2	PF00429
Domain	SLC12	SLC12A1 SLC12A9	2.03e-04	8	51	2	PF03522
Domain	TLV/ENV_coat_polyprotein	ERVV-2 ERVV-1	2.03e-04	8	51	2	IPR018154
Domain	SLC12_C	SLC12A1 SLC12A9	2.03e-04	8	51	2	IPR018491
Domain	MIP	AQP12A AQP12B	6.51e-04	14	51	2	PS00221
Domain	MIP	AQP12A AQP12B	6.51e-04	14	51	2	PF00230
Domain	-	AQP12A AQP12B	7.50e-04	15	51	2	1.20.1080.10
Domain	MIP	AQP12A AQP12B	7.50e-04	15	51	2	IPR000425
Domain	Aquaporin-like	AQP12A AQP12B	7.50e-04	15	51	2	IPR023271
Domain	PUA-like_domain	EOLA2 EOLA1	1.21e-03	19	51	2	IPR015947
Domain	SH3_9	RIMBP3 RIMBP3C RIMBP3B	1.26e-03	78	51	3	PF14604
Domain	AA-permease/SLC12A_dom	SLC12A1 SLC12A9	1.63e-03	22	51	2	IPR004841
Domain	AA_permease	SLC12A1 SLC12A9	1.63e-03	22	51	2	PF00324
Domain	SH3_2	RIMBP3 RIMBP3C RIMBP3B	1.67e-03	86	51	3	IPR011511
Domain	SH3_2	RIMBP3 RIMBP3C RIMBP3B	1.67e-03	86	51	3	PF07653
Domain	ARM-type_fold	RALGAPA1 MROH2A APOB USP9Y STAG3	2.27e-03	339	51	5	IPR016024
Domain	ubiquitin	DDI1 IKBKB	7.31e-03	47	51	2	PF00240
Pathway	BIOCARTA_CARM_ER_PATHWAY	BRCA1 PHB2 SPEN	3.21e-05	26	34	3	M2499
Pubmed	RIM-BP3 is a manchette-associated protein essential for spermiogenesis.	RIMBP3 RIMBP3C RIMBP3B	1.41e-08	4	54	3	19091768
Pubmed	Structure and evolution of RIM-BP genes: identification of a novel family member.	RIMBP3 RIMBP3C RIMBP3B	3.53e-08	5	54	3	17855024
Pubmed	Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.	RIMBP3 RIMBP3C RIMBP3B	1.27e-06	14	54	3	17662146
Pubmed	Genetic comparison of seizure control by norepinephrine and neuropeptide Y.	DBH NPY	2.37e-06	2	54	2	11567066
Pubmed	ABCG2, a novel antigen to sort luminal progenitors of BRCA1- breast cancer cells.	BRCA1 ABCG2	2.37e-06	2	54	2	25216750
Pubmed	Gene conversion and purifying selection of a placenta-specific ERV-V envelope gene during simian evolution.	ERVV-2 ERVV-1	2.37e-06	2	54	2	18826608
Pubmed	Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells.	AQP12A AQP12B	2.37e-06	2	54	2	15809071
Pubmed	Pancreas-specific aquaporin 12 null mice showed increased susceptibility to caerulein-induced acute pancreatitis.	AQP12A AQP12B	2.37e-06	2	54	2	19726746
Pubmed	Genetic analysis of the aquaporin water channels AQP12A and AQP12B in patients with chronic pancreatitis.	AQP12A AQP12B	2.37e-06	2	54	2	36167651
Pubmed	Differential evolutionary fate of an ancestral primate endogenous retrovirus envelope gene, the EnvV syncytin, captured for a function in placentation.	ERVV-2 ERVV-1	2.37e-06	2	54	2	23555306
Pubmed	Sensitivity and acquired resistance of BRCA1;p53-deficient mouse mammary tumors to the topoisomerase I inhibitor topotecan.	BRCA1 ABCG2	7.09e-06	3	54	2	20145144
Pubmed	Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically.	PRDX3 IKBKB	7.09e-06	3	54	2	12492477
Pubmed	Physiology of SLC12 transporters: lessons from inherited human genetic mutations and genetically engineered mouse knockouts.	SLC12A1 SLC12A9	7.09e-06	3	54	2	23325410
Pubmed	130 kb of DNA sequence reveals two new genes and a regional duplication distal to the human iduronate-2-sulfate sulfatase locus.	EOLA2 EOLA1	1.42e-05	4	54	2	8717057
Pubmed	Lack of ABCG2 shortens latency of BRCA1-deficient mammary tumors and this is not affected by genistein or resveratrol.	BRCA1 ABCG2	1.42e-05	4	54	2	22767648
Pubmed	Phenotype-genotype correlation in antenatal and neonatal variants of Bartter syndrome.	BSND SLC12A1	1.42e-05	4	54	2	19096086
Pubmed	Akt binds prohibitin 2 and relieves its repression of MyoD and muscle differentiation.	PHB2 MEF2A	3.54e-05	6	54	2	15173318
Pubmed	Reactivation of codogenic endogenous retroviral (ERV) envelope genes in human endometrial carcinoma and prestages: Emergence of new molecular targets.	ERVV-2 ERVV-1	3.54e-05	6	54	2	23085571
Pubmed	Molecular and phenotypic variation in patients with severe Hunter syndrome.	EOLA2 EOLA1	4.94e-05	7	54	2	9147653
Pubmed	Impairment in renal medulla development underlies salt wasting in Clc-k2 channel deficiency.	BSND SLC12A1	4.94e-05	7	54	2	34499620
Pubmed	Syncytins expressed in human placental trophoblast.	ERVV-2 ERVV-1	6.59e-05	8	54	2	33504453
Pubmed	BRCA1-mediated chromatin silencing is limited to oocytes with a small number of asynapsed chromosomes.	BRCA1 STAG3	8.46e-05	9	54	2	19531582
Pubmed	Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.	DGKB MAML2	8.46e-05	9	54	2	19176441
Pubmed	APOC3, CETP, fibrinogen, and MTHFR are genetic determinants of carotid intima-media thickness in healthy men (the Stanislas cohort).	APOB CBS	8.46e-05	9	54	2	11359462
Pubmed	[APOC3, CETP, beta-fibrinogen and MTHFR are genetic determinants of carotid intim-media thickness (Stanislas cohort)].	APOB CBS	8.46e-05	9	54	2	11575217
Pubmed	Cation-chloride cotransporters and neuronal function.	SLC12A1 SLC12A9	8.46e-05	9	54	2	19323993
Pubmed	Do Gametes Woo? Evidence for Their Nonrandom Union at Fertilization.	APOB ZIC2	1.29e-04	11	54	2	28978771
Pubmed	Genomic analysis of mouse retinal development.	ADGRG1 AKR1B1 MEF2A MTUS2 CEP164 CASZ1 NPY LRRC41	1.52e-04	1006	54	8	15226823
Pubmed	Genetic dissection of sodium and potassium transport along the aldosterone-sensitive distal nephron: importance in the control of blood pressure and hypertension.	BSND SLC12A1	1.55e-04	12	54	2	23684652
Pubmed	Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach.	ARHGAP36 DBH SAMM50	2.04e-04	73	54	3	23464991
Pubmed	Crucial role of TrkB ligands in the survival and phenotypic differentiation of developing locus coeruleus noradrenergic neurons.	DBH NPY	2.13e-04	14	54	2	12810600
Pubmed	Hoxd11 specifies a program of metanephric kidney development within the intermediate mesoderm of the mouse embryo.	BSND SLC12A1	2.13e-04	14	54	2	18485340
Pubmed	Phosphorylation of chromosome core components may serve as axis marks for the status of chromosomal events during mammalian meiosis.	BRCA1 STAG3	2.13e-04	14	54	2	22346761
Pubmed	Candidate gene polymorphisms in cardiovascular disease: a comparative study of frequencies between a French and an Italian population.	APOB CBS	2.45e-04	15	54	2	11341749
Pubmed	Aquaporins 8 and 9 as Possible Markers for Adult Murine Lacrimal Gland Cells.	AQP12A AQP12B	2.45e-04	15	54	2	34540996
Pubmed	Insm1 (IA-1) is a crucial component of the transcriptional network that controls differentiation of the sympatho-adrenal lineage.	DBH NPY	3.17e-04	17	54	2	18094025
Pubmed	Mapping genetic loci that regulate lipid levels in a NZB/B1NJxRF/J intercross and a combined intercross involving NZB/B1NJ, RF/J, MRL/MpJ, and SJL/J mouse strains.	APOB ABCG2	3.17e-04	17	54	2	17496333
Pubmed	Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance.	AQP12A AQP12B	3.17e-04	17	54	2	26847765
Pubmed	Severe acute respiratory syndrome coronavirus nonstructural protein 2 interacts with a host protein complex involved in mitochondrial biogenesis and intracellular signaling.	PHB2 SPEN	3.56e-04	18	54	2	19640993
Pubmed	Mice without macroH2A histone variants.	KRT23 NPY	3.98e-04	19	54	2	25312643
Pubmed	Expression patterns of the aquaporin gene family during renal development: influence of genetic variability.	AQP12A AQP12B	3.98e-04	19	54	2	19367412
Pubmed	Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.	APOB ABCG2	3.98e-04	19	54	2	23118302
Pubmed	Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1.	BRCA1 STAG3	3.98e-04	19	54	2	21478856
Pubmed	Can we predict top-level sports performance in power vs endurance events? A genetic approach.	APOB NPY	4.42e-04	20	54	2	20459474
Pubmed	Active IKKβ promotes the stability of GLI1 oncogene in diffuse large B-cell lymphoma.	PHB2 IKBKB	4.88e-04	21	54	2	26603838
Pubmed	The transcription factor Hmx1 and growth factor receptor activities control sympathetic neurons diversification.	DBH NPY	4.88e-04	21	54	2	23591430
Pubmed	Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.	APOB ABCG2	4.88e-04	21	54	2	21943158
Pubmed	Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.	DGKB APOB	5.86e-04	23	54	2	22399527
Pubmed	Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies.	BRCA1 APOB ABCG2	6.44e-04	108	54	3	19956635
Pubmed	Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development.	PHB2 APOB SAMM50	7.34e-04	113	54	3	30352685
Pubmed	Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney.	BSND SLC12A1	7.51e-04	26	54	2	20944551
Pubmed	ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.	DNHD1 BRCA1	8.10e-04	27	54	2	17525332
Pubmed	Excitatory neurons of the proprioceptive, interoceptive, and arousal hindbrain networks share a developmental requirement for Math1.	DBH NPY	8.10e-04	27	54	2	20080794
Pubmed	An evaluation of the assembly of an approximately 15-Mb region on human chromosome 13q32-q33 linked to bipolar disorder and schizophrenia.	TMTC4 ZIC2	9.35e-04	29	54	2	11991713
Pubmed	Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.	KCNQ5 ZIC2	9.35e-04	29	54	2	23396134
Pubmed	MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer.	PRDX3 PHB2 APOB CBS	1.04e-03	287	54	4	36180891
Pubmed	Genetic associations of brain structural networks in schizophrenia: a preliminary study.	APOB DBH	1.07e-03	31	54	2	20691427
Pubmed	Wnt1-cre-mediated conditional loss of Dicer results in malformation of the midbrain and cerebellum and failure of neural crest and dopaminergic differentiation in mice.	DBH NPY	1.07e-03	31	54	2	20457670
Pubmed	Multiple roles of FOXJ3 in spermatogenesis: A lesson from Foxj3 conditional knockout mouse models.	BRCA1 STAG3	1.14e-03	32	54	2	27739607
Pubmed	Diversification of molecularly defined myenteric neuron classes revealed by single-cell RNA sequencing.	DBH NPY	1.14e-03	32	54	2	33288908
Pubmed	Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.	APOB CBS NPY	1.39e-03	141	54	3	18636124
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	RALGAPA1 PHB2 SAMM50 USP9Y IKBKB	1.41e-03	533	54	5	25544563
Pubmed	Polymorphisms in DNA repair and one-carbon metabolism genes and overall survival in diffuse large B-cell lymphoma and follicular lymphoma.	BRCA1 CBS	1.44e-03	36	54	2	18830263
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	DNHD1 PRDX3 PHB2 APOB SAMM50 SPEN AKR1B1 CBS	1.51e-03	1425	54	8	30948266
Cytoband	22q11.21	RIMBP3 PI4KAP1 RIMBP3C RIMBP3B	9.32e-06	111	54	4	22q11.21
Cytoband	1p36	PAFAH2 SPEN	1.42e-03	47	54	2	1p36
Cytoband	Ensembl 112 genes in cytogenetic band chr22q11	RIMBP3 PI4KAP1 RIMBP3C RIMBP3B	1.51e-03	419	54	4	chr22q11
Cytoband	Ensembl 112 genes in cytogenetic band chr2q37	AQP12A MROH2A AQP12B	2.43e-03	226	54	3	chr2q37
Cytoband	2q37.3	AQP12A AQP12B	3.76e-03	77	54	2	2q37.3
Cytoband	11q23.3	SIK3 CEP164	3.85e-03	78	54	2	11q23.3
Cytoband	Ensembl 112 genes in cytogenetic band chr13q32	TMTC4 ZIC2	5.77e-03	96	54	2	chr13q32
GeneFamily	Aquaporins	AQP12A AQP12B	1.79e-04	14	26	2	305
ToppCell	droplet-Kidney-nan-3m-Epithelial-kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT23 BSND A4GALT ADGRG1 CASZ1	3.68e-06	193	54	5	0499611c21d283321ef6dd24add154dea48da1b7
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AQP12A KCNQ5 MATN4 CBS	8.41e-06	106	54	4	3aa55c3db4e4abd39c8f2f89f2516927d94ad9d7
Drug	DOPEG	LOXL2 DBH AKR1B1 NPY	9.74e-07	36	48	4	CID000091528
Drug	Coralyne chloride hydrate [38989-38-7]; Up 200; 9.6uM; PC3; HT_HG-U133A	RALGAPA1 PRDX3 A4GALT PAFAH2 IKBKB STAG3	3.74e-06	199	48	6	6317_UP
Drug	menthol glucuronide	APOB SPEN	1.30e-05	3	48	2	CID000133208
Drug	Gaviscon	BSND SPEN	1.30e-05	3	48	2	CID006336690
Drug	bromide;iodide	SLC12A1 SLC12A9	1.30e-05	3	48	2	CID009907214
Drug	coprine	LOXL2 DBH AKR1B1	1.32e-05	22	48	3	CID000108079
Drug	Ro 4-1284	LOXL2 DBH NPY	2.21e-05	26	48	3	CID000009345
Drug	copper	LOXL2 PRDX3 PAFAH2 APOB DBH AKR1B1 CBS NPY	2.32e-05	571	48	8	CID000023978
Drug	hepta-2,4-dienal	APOB AKR1B1	2.60e-05	4	48	2	CID000020307
Drug	dhmal	LOXL2 DBH AKR1B1	3.09e-05	29	48	3	CID000151725
Drug	AC1L8Y60	BSND SLC12A1 SLC12A9 CBS	3.72e-05	89	48	4	CID000410009
Drug	uranyl nitrate	SLC12A1 SLC12A9 PRDX3	4.18e-05	32	48	3	CID000024933
Drug	Zinc Oxide	SLC12A1 PRDX3 APOB DBH MTUS2 NPY	5.21e-05	317	48	6	ctd:D015034
Drug	2-Cl	SLC12A1 SLC12A9 AKR1B1	5.49e-05	35	48	3	CID000081058
Drug	Fusaric acid [536-69-6]; Up 200; 22.4uM; PC3; HT_HG-U133A	RALGAPA1 RNGTT PAFAH2 DBH USP9Y	5.70e-05	196	48	5	3986_UP
Drug	ST021200; Down 200; 10uM; PC3; HT_HG-U133A	RALGAPA1 RNGTT ADGRG1 CBS CEP164	5.70e-05	196	48	5	7559_DN
Drug	Sisomicin sulfate [53179-09-2]; Up 200; 2.8uM; PC3; HT_HG-U133A	KRT23 RNGTT LOXL2 PAFAH2 CBS	5.83e-05	197	48	5	4014_UP
Drug	Tolbutamide [64-77-7]; Up 200; 14.8uM; PC3; HT_HG-U133A	RNGTT LOXL2 A4GALT PAFAH2 ADGRG1	5.83e-05	197	48	5	4540_UP
Drug	AC1L1RWY	APOB AKR1B1	9.08e-05	7	48	2	CID000008901
Drug	DOPAC	LOXL2 DBH CBS NPY	9.14e-05	112	48	4	CID000000547
Disease	Bartter disease (is_implicated_in)	BSND SLC12A1	2.27e-06	2	45	2	DOID:445 (is_implicated_in)
Disease	arteriosclerosis (is_implicated_in)	APOB AKR1B1 NPY	1.45e-05	31	45	3	DOID:2349 (is_implicated_in)
Disease	Lymphoma, Non-Hodgkin	IKBKB SPEN CBS	1.59e-05	32	45	3	C0024305
Disease	Bartter Disease	BSND SLC12A1	2.27e-05	5	45	2	C0004775
Disease	Cardiovascular Diseases	APOB CBS NPY	2.28e-05	36	45	3	C0007222
Disease	Bartter syndrome	BSND SLC12A1	3.40e-05	6	45	2	cv:C0004775
Disease	triacylglycerol 54:4 measurement	APOB SIK3 MTUS2	4.81e-05	46	45	3	EFO_0010422
Disease	Diffuse Large B-Cell Lymphoma	PRDX3 ABCG2 SPEN	8.23e-05	55	45	3	C0079744
Disease	level of Triacylglycerol (51:3) in blood serum	APOB SIK3	1.02e-04	10	45	2	OBA_2045163
Disease	long QT syndrome (implicated_via_orthology)	KCNQ5 ARHGAP36	1.02e-04	10	45	2	DOID:2843 (implicated_via_orthology)
Disease	level of Diacylglycerol (18:1_18:1) in blood serum	APOB SIK3	1.24e-04	11	45	2	OBA_2045170
Disease	type 2 diabetes mellitus (is_implicated_in)	APOB IKBKB AKR1B1 NPY	1.35e-04	171	45	4	DOID:9352 (is_implicated_in)
Disease	vitamin D measurement	RNGTT APOB SIK3 MEF2A NPY	1.56e-04	336	45	5	EFO_0004631
Disease	response to statin, LDL cholesterol change measurement	APOB ABCG2	2.36e-04	15	45	2	EFO_0007804, GO_0036273
Disease	triacylglycerol 52:3 measurement	APOB SIK3	2.36e-04	15	45	2	EFO_0010415
Disease	alcohol use disorder (is_implicated_in)	DBH NPY	2.69e-04	16	45	2	DOID:1574 (is_implicated_in)
Disease	proprotein convertase subtilisin/kexin type 7 measurement	SIK3 CEP164	3.05e-04	17	45	2	EFO_0008270
Disease	acute lymphoblastic leukemia, response to antineoplastic agent	DGKB MAML2	3.83e-04	19	45	2	EFO_0000220, GO_0097327
Disease	very low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio	BSND APOB SAMM50 SIK3	4.82e-04	239	45	4	EFO_0008317, EFO_0020945
Disease	proprotein convertase subtilisin/kexin type 9 measurement	BSND APOB	5.15e-04	22	45	2	EFO_0009312
Disease	Mental Depression	BRCA1 DGKB DBH NPY	6.05e-04	254	45	4	C0011570
Disease	breast cancer (implicated_via_orthology)	BRCA1 CBS	6.67e-04	25	45	2	DOID:1612 (implicated_via_orthology)
Disease	PCSK9 protein measurement	BSND KCNQ5	7.22e-04	26	45	2	EFO_0006899
Disease	hypertension (is_implicated_in)	BRCA1 DBH NPY	8.42e-04	121	45	3	DOID:10763 (is_implicated_in)
Disease	Depressive disorder	BRCA1 DGKB DBH NPY	9.79e-04	289	45	4	C0011581
Disease	Malignant neoplasm of breast	BRCA1 TMTC4 LOXL2 ABCG2 SIK3 IKBKB SPEN	1.12e-03	1074	45	7	C0006142
Disease	chylomicron measurement, triglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement	APOB SIK3	1.24e-03	34	45	2	EFO_0008317, EFO_0008596, EFO_0020947
Disease	cholesteryl esters to total lipids in very large HDL percentage	APOB SIK3	1.39e-03	36	45	2	EFO_0022257
Disease	triacylglycerol 52:4 measurement	APOB SIK3	1.39e-03	36	45	2	EFO_0010416
Disease	cholesteryl esters to total lipids in medium LDL percentage	APOB SIK3	1.46e-03	37	45	2	EFO_0022252

Protein segments in the cluster

Peptide	Gene	Start	Entry
LGMTPAQIQALLRKG	EOLA1	61	Q8TE69
LGMTPAQIQALLRKG	EOLA2	61	Q96DE9
LPGTLLKLAAQGLGM	AQP12A	96	Q8IXF9
LVLMKGLPGGNASLP	A4GALT	111	Q9NPC4
MSQGNPGLGSLLNIK	CASZ1	961	Q86V15
NINGIMKPGLNAILG	ABCG2	66	Q9UNQ0
PRQKRALGLILAGMG	ERVV-2	316	B6SEH9
MGGPLGTAKLQSRNI	DNHD1	4711	Q96M86
LPGTLLKLAAQGLGM	AQP12B	96	A6NM10
LLNNGAKMPILGLGT	AKR1B1	6	P15121
LKPQLGLGAMSRLPS	MTUS2	766	Q5JR59
GQRLLGSKRKMSLNP	ARHGAP36	216	Q6ZRI8
GLLQSMGKQGLSRPL	RIMBP3B	971	A6NNM3
MGKQGLSRPLLGTKG	RIMBP3B	976	A6NNM3
GLLQSMGKQGLSRPL	RIMBP3C	971	A6NJZ7
MGKQGLSRPLLGTKG	RIMBP3C	976	A6NJZ7
GLQGLGSPALIRSML	DDI1	136	Q8WTU0
PQATLGGRLKGRNMQ	DTD2	91	Q96FN9
FLMGLLRGLNVGPNA	MATN4	56	O95460
LKITRMGGEGLLPQN	RNGTT	471	O60942
DLQRSPMGRKQGGTL	IKBKB	546	O14920
GKQGARMSLLGKPLS	KCNQ5	81	Q9NR82
TPAMGLQKKLRLNGG	LOXL2	426	Q9Y4K0
PRQKRALGLILAGMG	ERVV-1	316	B6SEH8
LLQRSMSLNIGGAKG	PI4KAP1	66	Q8N8J0
PLLGGNGKATMQNLN	KRT23	66	Q9C075
GGNLGMNSRKPDLRV	MEF2A	261	Q02078
PRGMGTALKLLLGAG	PHB2	16	Q99623
LNGQTMGPLRGLNLR	MAML2	1036	Q8IZL2
RGPKLNAMLRLGVLQ	BRCA1	1076	P38398
SGLNLRMAGPQGLDL	DERPC	261	P0CG12
GKLLLMGARTLQGIP	APOB	796	P04114
GILSPKAMGLLENGL	BSND	71	Q8WZ55
SGLQMGLQRVQLLKP	DBH	186	P09172
LGNMLSSLLAGKVQP	CBS	461	P35520
KPALLSGGLRMNKGA	DGKB	101	Q9Y6T7
MRLQARGGPSPLKSN	ADGRG1	661	Q9Y653
NLLKGIIGLMSRLSP	EDDM13	36	A0A1B0GTR0
GSMVLGLKLPNLLGR	SAMM50	141	Q9Y512
ILPGGLDLMTLKGNI	PAFAH2	211	Q99487
LSLRALGNMALGAPK	MROH2A	1406	A6NES4
AAMKGNSTLKGLRLP	LRRC41	696	Q15345
GLLQSMGKQGLSRPL	RIMBP3	971	Q9UFD9
MGKQGLSRPLLGTKG	RIMBP3	976	Q9UFD9
TLQLLNGMGPLGRRA	SIK3	536	Q9Y2K2
RSLLQASGLGRMKPN	SLC12A1	761	Q13621
TPRKNGGLGHMNIAL	PRDX3	146	P30048
GRQLGELMLPSQGLK	CEP164	176	Q9UPV0
KSLENLGMLRNGGLL	TMTC4	256	Q5T4D3
GKKNMTLAGRLAGPL	RALGAPA1	606	Q6GYQ0
LGNNRLKLGFGKSMP	SPEN	501	Q96T58
PSGPGLGNQLMRLSL	STAG3	1161	Q9UJ98
QHLLRISGLGGMKPN	SLC12A9	611	Q9BXP2
MLGNKRLGLSGLTLA	NPY	1	P01303
SGGLPLVLSMLIRNN	USP9Y	1121	O00507
LAALRGPMQLTLGGA	TMEM160	121	Q9NX00
SQNVLNGQMRLGLPG	ZIC2	171	O95409