Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionextracellular matrix structural constituent

LAMA5 VWF HMCN1 AGRN FBN3

4.50e-05188425GO:0005201
GeneOntologyBiologicalProcessWnt signaling pathway involved in forebrain neuroblast division

LRP6 WNT3A

3.86e-062412GO:0021874
GeneOntologyBiologicalProcesssegmentation

LAMA5 TDRD5 LRP6 ZEB2 WNT3A

4.39e-06123415GO:0035282
GeneOntologyBiologicalProcesspositive regulation of protein kinase activity

TRAF6 PRKAG2 AGRN ZEB2 WNK4 WNT3A CD40

5.22e-06350417GO:0045860
GeneOntologyBiologicalProcesspositive regulation of phosphate metabolic process

LRP4 DRD1 TRAF6 PRKAG2 AGRN ZEB2 WNK4 NR1H4 WNT3A CD40

6.32e-068794110GO:0045937
GeneOntologyBiologicalProcesspositive regulation of phosphorus metabolic process

LRP4 DRD1 TRAF6 PRKAG2 AGRN ZEB2 WNK4 NR1H4 WNT3A CD40

6.32e-068794110GO:0010562
GeneOntologyBiologicalProcesspositive regulation of protein phosphorylation

LRP4 DRD1 TRAF6 PRKAG2 AGRN ZEB2 WNK4 WNT3A CD40

9.84e-06724419GO:0001934
GeneOntologyBiologicalProcessresponse to nutrient levels

MPO UGT1A1 LRP6 PRKAG2 ZEB2 WNK4 NR1H4 CD40

1.32e-05566418GO:0031667
GeneOntologyBiologicalProcesspositive regulation of kinase activity

TRAF6 PRKAG2 AGRN ZEB2 WNK4 WNT3A CD40

1.35e-05405417GO:0033674
GeneOntologyBiologicalProcesspositive regulation of phosphorylation

LRP4 DRD1 TRAF6 PRKAG2 AGRN ZEB2 WNK4 WNT3A CD40

1.78e-05780419GO:0042327
GeneOntologyBiologicalProcessregulation of protein kinase activity

LRP6 TRAF6 PRKAG2 AGRN ZEB2 WNK4 WNT3A CD40

2.28e-05611418GO:0045859
GeneOntologyBiologicalProcessregulation of transferase activity

LRP6 TRAF6 PRKAG2 AGRN ZEB2 WNK4 WNT3A PARP3 CD40

2.40e-05810419GO:0051338
GeneOntologyBiologicalProcesspositive regulation of transferase activity

TRAF6 PRKAG2 AGRN ZEB2 WNK4 WNT3A CD40

4.57e-05490417GO:0051347
GeneOntologyBiologicalProcessregulation of kinase activity

LRP6 TRAF6 PRKAG2 AGRN ZEB2 WNK4 WNT3A CD40

5.19e-05686418GO:0043549
GeneOntologyBiologicalProcesstube morphogenesis

LAMA5 LRP6 GJA5 TRAF6 SH2B3 ZEB2 WNK4 WNT3A STAB1 CD40

5.32e-0511254110GO:0035239
GeneOntologyBiologicalProcessregulation of protein phosphorylation

LRP4 LRP6 DRD1 TRAF6 PRKAG2 AGRN ZEB2 WNK4 WNT3A CD40

5.65e-0511334110GO:0001932
GeneOntologyBiologicalProcessaxis elongation involved in somitogenesis

LRP6 WNT3A

5.75e-056412GO:0090245
GeneOntologyBiologicalProcessodontogenesis of dentin-containing tooth

LRP4 LAMA5 LRP6 TRAF6

5.98e-05107414GO:0042475
GeneOntologyBiologicalProcessregulation of phosphate metabolic process

LRP4 LRP6 DRD1 TRAF6 PRKAG2 AGRN ZEB2 WNK4 NR1H4 WNT3A CD40

7.35e-0514214111GO:0019220
GeneOntologyBiologicalProcessregulation of phosphorus metabolic process

LRP4 LRP6 DRD1 TRAF6 PRKAG2 AGRN ZEB2 WNK4 NR1H4 WNT3A CD40

7.44e-0514234111GO:0051174
GeneOntologyBiologicalProcesspositive regulation of protein modification process

LRP4 DRD1 TRAF6 PRKAG2 AGRN ZEB2 WNK4 WNT3A CD40

7.47e-05937419GO:0031401
GeneOntologyBiologicalProcessforebrain neuroblast division

LRP6 WNT3A

8.04e-057412GO:0021873
GeneOntologyBiologicalProcessregulation of protein localization to membrane

LRP4 TRAF6 AGRN WNK4 WNT3A

1.03e-04237415GO:1905475
GeneOntologyBiologicalProcessregulation of phosphorylation

LRP4 LRP6 DRD1 TRAF6 PRKAG2 AGRN ZEB2 WNK4 WNT3A CD40

1.09e-0412264110GO:0042325
GeneOntologyBiologicalProcessnegative regulation of multicellular organismal process

LRP4 LRP6 GJA5 DRD1 SH2B3 WNK4 NR1H4 WNT3A PARP3 CGA STAB1

1.11e-0414884111GO:0051241
GeneOntologyBiologicalProcessregulation of steroid metabolic process

UGT1A1 MALRD1 NR1H4 CGA

1.47e-04135414GO:0019218
GeneOntologyBiologicalProcessepithelial tube morphogenesis

LAMA5 LRP6 TRAF6 ZEB2 WNK4 WNT3A

1.71e-04421416GO:0060562
GeneOntologyBiologicalProcesspotassium ion transport

KCNH6 GJA5 DRD1 AGRN WNK4

1.95e-04272415GO:0006813
GeneOntologyBiologicalProcesssynaptic assembly at neuromuscular junction

LRP4 AGRN

2.10e-0411412GO:0051124
GeneOntologyBiologicalProcessregulation of body fluid levels

GJA5 VWF SH2B3 WNK4 WNT3A CD40

2.23e-04442416GO:0050878
GeneOntologyBiologicalProcessodontogenesis

LRP4 LAMA5 LRP6 TRAF6

2.26e-04151414GO:0042476
GeneOntologyBiologicalProcessregulation of bile acid biosynthetic process

MALRD1 NR1H4

2.51e-0412412GO:0070857
GeneOntologyBiologicalProcesspositive regulation of skeletal muscle acetylcholine-gated channel clustering

LRP4 AGRN

2.51e-0412412GO:1904395
GeneOntologyBiologicalProcessplatelet activation

VWF SH2B3 WNT3A CD40

2.69e-04158414GO:0030168
GeneOntologyBiologicalProcesstube development

LAMA5 LRP6 GJA5 TRAF6 SH2B3 ZEB2 WNK4 WNT3A STAB1 CD40

3.27e-0414024110GO:0035295
GeneOntologyBiologicalProcessregionalization

LRP4 LAMA5 TDRD5 LRP6 ZEB2 WNT3A

3.39e-04478416GO:0003002
GeneOntologyBiologicalProcessregulation of bile acid metabolic process

MALRD1 NR1H4

3.98e-0415412GO:1904251
GeneOntologyBiologicalProcessregulation of skeletal muscle acetylcholine-gated channel clustering

LRP4 AGRN

3.98e-0415412GO:1904393
GeneOntologyBiologicalProcessprotein localization to membrane

LRP4 LAMA5 LRP6 TRAF6 AGRN WNK4 WNT3A

4.32e-04705417GO:0072657
GeneOntologyBiologicalProcessneuroblast division

LRP6 WNT3A

4.55e-0416412GO:0055057
GeneOntologyBiologicalProcessembryonic morphogenesis

LRP4 LAMA5 LRP6 GJA5 TRAF6 ZEB2 WNT3A

4.62e-04713417GO:0048598
GeneOntologyBiologicalProcesssomitogenesis

LRP6 ZEB2 WNT3A

4.63e-0476413GO:0001756
GeneOntologyBiologicalProcessregulation of protein modification process

LRP4 LRP6 DRD1 TRAF6 PRKAG2 AGRN ZEB2 WNK4 WNT3A CD40

5.25e-0414884110GO:0031399
GeneOntologyBiologicalProcessregulation of ketone metabolic process

UGT1A1 MALRD1 PRKAG2 NR1H4

5.31e-04189414GO:0010565
GeneOntologyBiologicalProcessmorphogenesis of embryonic epithelium

LAMA5 LRP6 TRAF6 ZEB2

5.41e-04190414GO:0016331
GeneOntologyBiologicalProcessresponse to nutrient

UGT1A1 LRP6 NR1H4 CD40

5.63e-04192414GO:0007584
GeneOntologyBiologicalProcesspattern specification process

LRP4 LAMA5 TDRD5 LRP6 ZEB2 WNT3A

5.63e-04526416GO:0007389
GeneOntologyBiologicalProcesspositive regulation of peptidyl-tyrosine phosphorylation

LRP4 AGRN WNT3A CD40

5.74e-04193414GO:0050731
GeneOntologyBiologicalProcessmidbrain dopaminergic neuron differentiation

LRP6 WNT3A

5.78e-0418412GO:1904948
GeneOntologyBiologicalProcesspositive regulation of Rac protein signal transduction

LRP4 AGRN

5.78e-0418412GO:0035022
GeneOntologyBiologicalProcesscellular response to interleukin-1

TRAF6 IL1RL2 CD40

6.43e-0485413GO:0071347
GeneOntologyBiologicalProcesspositive regulation of receptor clustering

LRP4 AGRN

6.45e-0419412GO:1903911
GeneOntologyBiologicalProcessmetal ion transport

TRPM6 KCNH6 GJA5 DRD1 SLC41A1 AGRN WNK4 WNT3A

6.80e-041000418GO:0030001
GeneOntologyBiologicalProcessneural tube development

LRP6 TRAF6 ZEB2 WNT3A

6.81e-04202414GO:0021915
GeneOntologyBiologicalProcessorganic hydroxy compound transport

SLC44A2 LRP6 DRD1 WNK4 NR1H4

6.87e-04358415GO:0015850
GeneOntologyBiologicalProcessgland development

UGT1A1 LAMA5 LRP6 VWF WNT3A CGA

7.67e-04558416GO:0048732
GeneOntologyBiologicalProcesssteroid biosynthetic process

MALRD1 PRKAG2 NR1H4 CGA

7.73e-04209414GO:0006694
GeneOntologyBiologicalProcessembryonic pattern specification

LAMA5 TDRD5 LRP6

7.84e-0491413GO:0009880
GeneOntologyBiologicalProcessskeletal muscle acetylcholine-gated channel clustering

LRP4 AGRN

7.90e-0421412GO:0071340
GeneOntologyBiologicalProcesspositive regulation of catalytic activity

DRD1 TRAF6 PRKAG2 AGRN ZEB2 WNK4 WNT3A CD40

8.15e-041028418GO:0043085
GeneOntologyBiologicalProcesscell junction assembly

LRP4 GJA5 DRD1 AGRN NR1H4 WNT3A

8.49e-04569416GO:0034329
GeneOntologyBiologicalProcesssteroid metabolic process

UGT1A1 MALRD1 PRKAG2 NR1H4 CGA

8.56e-04376415GO:0008202
GeneOntologyBiologicalProcesssomite development

LRP6 ZEB2 WNT3A

8.62e-0494413GO:0061053
GeneOntologyBiologicalProcessnegative regulation of sodium ion transport

AGRN WNK4

8.68e-0422412GO:0010766
GeneOntologyBiologicalProcessregulation of immunoglobulin production

TRAF6 PARP3 CD40

8.89e-0495413GO:0002637
GeneOntologyBiologicalProcessinflammatory response

UGT1A1 VWF IL1RL2 ZEB2 WNK4 NR1H4 STAB1 CD40

8.96e-041043418GO:0006954
GeneOntologyBiologicalProcesslocalization within membrane

LRP4 LAMA5 LRP6 TRAF6 AGRN WNK4 WNT3A

9.00e-04798417GO:0051668
GeneOntologyBiologicalProcesspallium development

LRP6 DRD1 ZEB2 WNT3A

9.68e-04222414GO:0021543
GeneOntologyBiologicalProcessregulation of embryonic development

LAMA5 LRP6 WNT3A

1.00e-0399413GO:0045995
GeneOntologyBiologicalProcessembryonic heart tube development

LRP6 GJA5 WNT3A

1.12e-03103413GO:0035050
GeneOntologyBiologicalProcessregulation of ventricular cardiac muscle cell membrane repolarization

KCNH6 GJA5

1.12e-0325412GO:0060307
GeneOntologyBiologicalProcesscell activation

TRAF6 VWF SH2B3 IL1RL2 ZEB2 WNK4 WNT3A PARP3 CD40

1.15e-031356419GO:0001775
GeneOntologyBiologicalProcessneural crest cell differentiation

LAMA5 LRP6 ZEB2

1.15e-03104413GO:0014033
GeneOntologyBiologicalProcessregulation of protein localization

LRP4 GJA5 TRAF6 MALRD1 AGRN WNK4 NR1H4 WNT3A

1.17e-031087418GO:0032880
GeneOntologyBiologicalProcessregulation of steroid biosynthetic process

MALRD1 NR1H4 CGA

1.22e-03106413GO:0050810
GeneOntologyBiologicalProcessdorsal/ventral pattern formation

LRP4 LRP6 WNT3A

1.25e-03107413GO:0009953
GeneOntologyBiologicalProcessregulation of lymphocyte activation

TRAF6 SH2B3 IL1RL2 WNT3A PARP3 CD40

1.26e-03614416GO:0051249
GeneOntologyBiologicalProcesshippocampus development

DRD1 ZEB2 WNT3A

1.29e-03108413GO:0021766
GeneOntologyBiologicalProcessmorphogenesis of an epithelium

LAMA5 LRP6 TRAF6 ZEB2 WNK4 WNT3A

1.31e-03619416GO:0002009
GeneOntologyBiologicalProcessregulation of lipid metabolic process

UGT1A1 MALRD1 PRKAG2 NR1H4 CGA

1.33e-03415415GO:0019216
GeneOntologyBiologicalProcessresponse to interleukin-1

TRAF6 IL1RL2 CD40

1.43e-03112413GO:0070555
GeneOntologyBiologicalProcessprotein localization to cell periphery

LAMA5 LRP6 TRAF6 WNK4 WNT3A

1.43e-03422415GO:1990778
GeneOntologyBiologicalProcessanterior/posterior pattern specification

TDRD5 LRP6 ZEB2 WNT3A

1.44e-03247414GO:0009952
GeneOntologyBiologicalProcessneural tube closure

LRP6 TRAF6 ZEB2

1.47e-03113413GO:0001843
GeneOntologyBiologicalProcesstube closure

LRP6 TRAF6 ZEB2

1.50e-03114413GO:0060606
GeneOntologyBiologicalProcesspost-anal tail morphogenesis

LRP6 WNT3A

1.51e-0329412GO:0036342
GeneOntologyBiologicalProcessregulation of receptor clustering

LRP4 AGRN

1.51e-0329412GO:1903909
GeneOntologyBiologicalProcessorganic hydroxy compound metabolic process

DRD1 MALRD1 PRKAG2 ZEB2 NR1H4 CGA

1.57e-03641416GO:1901615
GeneOntologyBiologicalProcessventricular cardiac muscle cell membrane repolarization

KCNH6 GJA5

1.62e-0330412GO:0099625
GeneOntologyBiologicalProcessregulation of cardiac muscle cell membrane repolarization

KCNH6 GJA5

1.62e-0330412GO:0099623
GeneOntologyBiologicalProcessblood circulation

KCNH6 GJA5 DRD1 AGRN ZEB2 WNK4

1.66e-03648416GO:0008015
GeneOntologyBiologicalProcesspositive regulation of molecular function

LRP6 DRD1 TRAF6 PRKAG2 AGRN ZEB2 WNK4 WNT3A CD40

1.67e-031430419GO:0044093
GeneOntologyBiologicalProcessembryo development

LRP4 LAMA5 TDRD5 LRP6 GJA5 TRAF6 SH2B3 ZEB2 WNT3A

1.73e-031437419GO:0009790
GeneOntologyBiologicalProcessblood coagulation

VWF SH2B3 WNT3A CD40

1.73e-03260414GO:0007596
GeneOntologyBiologicalProcessprimary neural tube formation

LRP6 TRAF6 ZEB2

1.74e-03120413GO:0014020
GeneOntologyBiologicalProcessmonoatomic cation transport

TRPM6 KCNH6 GJA5 DRD1 SLC41A1 AGRN WNK4 WNT3A

1.74e-031157418GO:0006812
GeneOntologyBiologicalProcesspositive regulation of DNA-binding transcription factor activity

LRP6 TRAF6 WNT3A CD40

1.76e-03261414GO:0051091
GeneOntologyBiologicalProcessregulation of potassium ion transport

DRD1 AGRN WNK4

1.78e-03121413GO:0043266
GeneOntologyBiologicalProcesscellular response to oxygen-containing compound

MPO UGT1A1 LRP6 DRD1 TRAF6 AGRN NR1H4 WNT3A CD40

1.84e-031450419GO:1901701
GeneOntologyBiologicalProcessendocrine process

GJA5 WNK4 CGA

1.87e-03123413GO:0050886
GeneOntologyBiologicalProcessregulation of DNA-binding transcription factor activity

LRP6 TRAF6 NR1H4 WNT3A CD40

1.88e-03449415GO:0051090
GeneOntologyCellularComponentWnt-Frizzled-LRP5/6 complex

LRP6 WNT3A

3.74e-055412GO:1990851
GeneOntologyCellularComponentCD40 receptor complex

TRAF6 CD40

2.04e-0411412GO:0035631
GeneOntologyCellularComponentWnt signalosome

LRP6 WNT3A

4.43e-0416412GO:1990909
GeneOntologyCellularComponentkeratin filament

KRTAP1-5 KRTAP1-1 KRTAP1-3

9.09e-0497413GO:0045095
GeneOntologyCellularComponentGolgi lumen

AGRN WNT3A CGA

1.27e-03109413GO:0005796
GeneOntologyCellularComponentextracellular matrix

LAMA5 VWF HMCN1 OTOGL AGRN FBN3

1.65e-03656416GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

LAMA5 VWF HMCN1 OTOGL AGRN FBN3

1.67e-03658416GO:0030312
GeneOntologyCellularComponentbasement membrane

LAMA5 HMCN1 AGRN

1.76e-03122413GO:0005604
GeneOntologyCellularComponentsynaptic cleft

LAMA5 AGRN

1.91e-0333412GO:0043083
DomainEGF

LRP4 LRP6 MALRD1 HMCN1 AGRN FBN3 STAB1

9.99e-09126417PF00008
DomainEGF

LRP4 LAMA5 LRP6 MALRD1 HMCN1 AGRN FBN3 STAB1

3.73e-08235418SM00181
DomainEGF-like_dom

LRP4 LAMA5 LRP6 MALRD1 HMCN1 AGRN FBN3 STAB1

5.83e-08249418IPR000742
DomainEGF_1

LRP4 LAMA5 LRP6 MALRD1 HMCN1 AGRN FBN3 STAB1

7.00e-08255418PS00022
DomainEGF-like_CS

LRP4 LAMA5 LRP6 MALRD1 HMCN1 AGRN FBN3 STAB1

8.38e-08261418IPR013032
DomainEGF_2

LRP4 LAMA5 LRP6 MALRD1 HMCN1 AGRN FBN3 STAB1

9.42e-08265418PS01186
DomainEGF_3

LRP4 LRP6 MALRD1 HMCN1 AGRN FBN3 STAB1

7.13e-07235417PS50026
DomainEGF_CA

LRP4 HMCN1 AGRN FBN3 STAB1

6.80e-06122415SM00179
DomainEGF-like_Ca-bd_dom

LRP4 HMCN1 AGRN FBN3 STAB1

7.36e-06124415IPR001881
DomainGrowth_fac_rcpt_

LRP4 LAMA5 HMCN1 FBN3 STAB1

2.24e-05156415IPR009030
DomaincEGF

LRP4 HMCN1 FBN3

2.46e-0526413IPR026823
DomaincEGF

LRP4 HMCN1 FBN3

2.46e-0526413PF12662
DomainEGF_LAM_2

LAMA5 AGRN STAB1

3.83e-0530413PS50027
DomainEGF_LAM_1

LAMA5 AGRN STAB1

3.83e-0530413PS01248
DomainTNFR/NGFR_Cys_rich_reg

TNFRSF6B LAMA5 CD40

5.12e-0533413IPR001368
DomainLaminin_EGF

LAMA5 AGRN STAB1

6.12e-0535413PF00053
DomainEGF_Lam

LAMA5 AGRN STAB1

6.12e-0535413SM00180
DomainLaminin_EGF

LAMA5 AGRN STAB1

7.85e-0538413IPR002049
DomainLDLR_class-A_CS

LRP4 LRP6 MALRD1

9.17e-0540413IPR023415
DomainKeratin_B2

KRTAP1-5 KRTAP1-1 KRTAP1-3

9.17e-0540413PF01500
DomainLdl_recept_a

LRP4 LRP6 MALRD1

1.31e-0445413PF00057
Domain-

LRP4 LRP6 MALRD1

1.40e-04464134.10.400.10
DomainLDLRA_1

LRP4 LRP6 MALRD1

1.59e-0448413PS01209
DomainLDLRA_2

LRP4 LRP6 MALRD1

1.69e-0449413PS50068
DomainLDrepeatLR_classA_rpt

LRP4 LRP6 MALRD1

1.69e-0449413IPR002172
DomainLDLa

LRP4 LRP6 MALRD1

1.69e-0449413SM00192
Domain-

HMCN1 STAB1

2.55e-04114122.40.155.10
DomainGFP-like

HMCN1 STAB1

2.55e-0411412IPR023413
DomainKAP

KRTAP1-5 KRTAP1-1 KRTAP1-3

2.79e-0458413IPR002494
DomainLdl_recept_b

LRP4 LRP6

4.21e-0414412PF00058
DomainLDLRB

LRP4 LRP6

4.21e-0414412PS51120
DomainLY

LRP4 LRP6

4.85e-0415412SM00135
DomainLDLR_classB_rpt

LRP4 LRP6

4.85e-0415412IPR000033
DomainEGF_CA

LRP4 HMCN1 FBN3

8.85e-0486413PF07645
DomainTNFR_c6

TNFRSF6B CD40

1.06e-0322412PF00020
DomainEGF_Ca-bd_CS

LRP4 HMCN1 FBN3

1.25e-0397413IPR018097
DomainEGF_CA

LRP4 HMCN1 FBN3

1.33e-0399413PS01187
DomainASX_HYDROXYL

LRP4 HMCN1 FBN3

1.37e-03100413PS00010
DomainTNFR

TNFRSF6B CD40

1.48e-0326412SM00208
DomainEGF-type_Asp/Asn_hydroxyl_site

LRP4 HMCN1 FBN3

1.62e-03106413IPR000152
DomainTNFR_NGFR_1

TNFRSF6B CD40

1.84e-0329412PS00652
DomainTNFR_NGFR_2

TNFRSF6B CD40

1.84e-0329412PS50050
DomainLAM_G_DOMAIN

LAMA5 AGRN

3.14e-0338412PS50025
Domain-

LRP4 LRP6

3.31e-03394122.120.10.30
DomainLamG

LAMA5 AGRN

4.20e-0344412SM00282
Domain6-blade_b-propeller_TolB-like

LRP4 LRP6

4.58e-0346412IPR011042
DomainLaminin_G

LAMA5 AGRN

7.19e-0358412IPR001791
Pubmed

Polymorphisms in the human high sulfur hair keratin-associated protein 1, KAP1, gene family.

KRTAP1-5 KRTAP1-1 KRTAP1-3

6.54e-09442312228244
Pubmed

TRAF6 function as a novel co-regulator of Wnt3a target genes in prostate cancer.

LRP6 TRAF6 WNT3A

1.63e-08542331262711
Pubmed

Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.

MPO TNFRSF6B LRP6 DRD1 NR1H4 CGA CD40

3.48e-0738142718676680
Pubmed

Genetic susceptibility to distinct bladder cancer subphenotypes.

MPO LRP6 DRD1 NR1H4 PARP3 CGA CD40

6.78e-0742142719692168
Pubmed

Segregated Foxc2, NFATc1 and Connexin expression at normal developing venous valves, and Connexin-specific differences in the valve phenotypes of Cx37, Cx43, and Cx47 knockout mice.

LAMA5 GJA5 VWF

9.07e-071642326953188
Pubmed

Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: implication for breast cancer tumorigenesis.

LRP6 WNT3A

1.42e-06242219881541
Pubmed

Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance.

TRAF6 CD40

1.42e-06242224492375
Pubmed

Impaired adhesion of neutrophils expressing Slc44a2/HNA-3b to VWF protects against NETosis under venous shear rates.

SLC44A2 VWF

1.42e-06242233556175
Pubmed

Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region.

TRAF6 CD40

1.42e-0624228910514
Pubmed

CD40-mediated cell death requires TRAF6 recruitment.

TRAF6 CD40

1.42e-06242221813202
Pubmed

Transcriptional Control of Trpm6 by the Nuclear Receptor FXR.

TRPM6 NR1H4

1.42e-06242235216094
Pubmed

Molecular mechanisms of TNFR-associated factor 6 (TRAF6) utilization by the oncogenic viral mimic of CD40, latent membrane protein 1 (LMP1).

TRAF6 CD40

1.42e-06242221262968
Pubmed

Lrp4 is a retrograde signal for presynaptic differentiation at neuromuscular synapses.

LRP4 AGRN

1.42e-06242222854782
Pubmed

TNF receptor-associated factor 6 is an essential mediator of CD40-activated proinflammatory pathways in monocytes and macrophages.

TRAF6 CD40

1.42e-06242215634933
Pubmed

Wise retained in the endoplasmic reticulum inhibits Wnt signaling by reducing cell surface LRP6.

LRP6 WNT3A

1.42e-06242217765217
Pubmed

The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells.

TRAF6 CD40

1.42e-06242211967542
Pubmed

Distinct molecular mechanism for initiating TRAF6 signalling.

TRAF6 CD40

1.42e-06242212140561
Pubmed

Clathrin and AP2 are required for PtdIns(4,5)P2-mediated formation of LRP6 signalosomes.

LRP6 WNT3A

1.42e-06242223400998
Pubmed

Inhibition of CD40-TRAF6-dependent inflammatory activity halts the onset of diabetic retinopathy in streptozotocin-diabetic mice.

TRAF6 CD40

1.42e-06242236309487
Pubmed

A novel mechanism for TNFR-associated factor 6-dependent CD40 signaling.

TRAF6 CD40

1.42e-06242217878362
Pubmed

Analysis of endogenous LRP6 function reveals a novel feedback mechanism by which Wnt negatively regulates its receptor.

LRP6 WNT3A

1.42e-06242217698587
Pubmed

Tumor necrosis factor receptor-associated factor 6 (TRAF6) stimulates extracellular signal-regulated kinase (ERK) activity in CD40 signaling along a ras-independent pathway.

TRAF6 CD40

1.42e-0624229432981
Pubmed

Tyrosine-based signal mediates LRP6 receptor endocytosis and desensitization of Wnt/β-catenin pathway signaling.

LRP6 WNT3A

4.27e-06342225143377
Pubmed

TRAF6 is a critical regulator of LMP1 functions in vivo.

TRAF6 CD40

4.27e-06342224170780
Pubmed

Distinct contributions of different CD40 TRAF binding sites to CD154-induced dendritic cell maturation and IL-12 secretion.

TRAF6 CD40

4.27e-06342212616498
Pubmed

Functional caveolae are a prerequisite for CD40 signaling in human renal proximal tubule cells.

TRAF6 CD40

4.27e-06342214665433
Pubmed

Sequence and structural difference favors a distinct preference of Wnt3a binding with co-receptor LRP6.

LRP6 WNT3A

4.27e-06342225425204
Pubmed

Roles of the kinase TAK1 in TRAF6-dependent signaling by CD40 and its oncogenic viral mimic, LMP1.

TRAF6 CD40

4.27e-06342222860133
Pubmed

Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation.

LRP6 WNT3A

4.27e-06342217569865
Pubmed

MuSK myasthenia gravis IgG4 disrupts the interaction of LRP4 with MuSK but both IgG4 and IgG1-3 can disperse preformed agrin-independent AChR clusters.

LRP4 AGRN

4.27e-06342224244707
Pubmed

Agrin binds to the N-terminal region of Lrp4 protein and stimulates association between Lrp4 and the first immunoglobulin-like domain in muscle-specific kinase (MuSK).

LRP4 AGRN

4.27e-06342221969364
Pubmed

Blocking of the interaction between Wnt proteins and their co-receptors contributes to the anti-tumor effects of adenovirus-mediated DKK3 in glioblastoma.

LRP6 WNT3A

4.27e-06342225301448
Pubmed

Wnt3a-stimulated LRP6 phosphorylation is dependent upon arginine methylation of G3BP2.

LRP6 WNT3A

4.27e-06342222357953
Pubmed

A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor.

LRP6 WNT3A

4.27e-06342212897152
Pubmed

Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells.

LRP6 WNT3A

4.27e-06342230664649
Pubmed

The CD40-TRAF6 axis is the key regulator of the CD40/CD40L system in neointima formation and arterial remodeling.

TRAF6 CD40

4.27e-06342218195092
Pubmed

Endothelial CD40 Mediates Microvascular von Willebrand Factor-Dependent Platelet Adhesion Inducing Inflammatory Venothrombosis in ADAMTS13 Knockout Mice.

VWF CD40

4.27e-06342232135568
Pubmed

PTEN identified as important risk factor of chronic obstructive pulmonary disease.

MPO LRP6 DRD1 NR1H4 CGA CD40

5.62e-0637442619625176
Pubmed

Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.

MPO LRP6 DRD1 NR1H4 CGA CD40

6.34e-0638242619170196
Pubmed

Integrative predictive model of coronary artery calcification in atherosclerosis.

VWF PRKAG2 HMCN1 NR1H4 CD40

8.26e-0622942519948975
Pubmed

The low-density lipoprotein receptor-related protein 10 is a negative regulator of the canonical Wnt/beta-catenin signaling pathway.

LRP4 LRP6

8.53e-06442220093106
Pubmed

p62 regulates CD40-mediated NFκB activation in macrophages through interaction with TRAF6.

TRAF6 CD40

8.53e-06442226133577
Pubmed

Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function.

LRP4 LRP6

8.53e-06442221471202
Pubmed

IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis.

LRP6 WNT3A

8.53e-06442218528331
Pubmed

Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile.

TRAF6 CD40

8.53e-06442220100871
Pubmed

Wnt5a regulates distinct signalling pathways by binding to Frizzled2.

LRP6 WNT3A

8.53e-06442219910923
Pubmed

Cholesterol depletion associated with Leishmania major infection alters macrophage CD40 signalosome composition and effector function.

TRAF6 CD40

8.53e-06442219198591
Pubmed

Crystallographic analysis of CD40 recognition and signaling by human TRAF2.

TRAF6 CD40

8.53e-06442210411888
Pubmed

Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts.

LRP6 WNT3A

8.53e-06442229176883
Pubmed

The collagen ColQ binds to LRP4 and regulates the activation of the Muscle-Specific Kinase-LRP4 receptor complex by agrin at the neuromuscular junction.

LRP4 AGRN

8.53e-06442237356721
Pubmed

Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation.

LRP6 WNT3A

8.53e-06442222726442
Pubmed

Blockade of CD40-TRAF2,3 or CD40-TRAF6 is sufficient to inhibit pro-inflammatory responses in non-haematopoietic cells.

TRAF6 CD40

8.53e-06442225051892
Pubmed

The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4.

TRAF6 CD40

8.53e-06442224812060
Pubmed

The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching.

TRAF6 CD40

8.53e-06442212354380
Pubmed

The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway.

LRP6 WNT3A

8.53e-06442214739301
Pubmed

Shh Plays an Inhibitory Role in Cusp Patterning by Regulation of Sostdc1.

LRP4 LRP6

8.53e-06442230325689
Pubmed

The VWF/LRP4/αVβ3-axis represents a novel pathway regulating proliferation of human vascular smooth muscle cells.

LRP4 VWF

8.53e-06442233576766
Pubmed

TRAF6 is required for TRAF2-dependent CD40 signal transduction in nonhemopoietic cells.

TRAF6 CD40

8.53e-06442216260598
Pubmed

An agrin minigene rescues dystrophic symptoms in a mouse model for congenital muscular dystrophy.

LAMA5 AGRN

8.53e-06442211565031
Pubmed

Characterization of a cluster of human high/ultrahigh sulfur keratin-associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21.

KRTAP1-5 KRTAP1-1 KRTAP1-3

1.24e-053742311279113
Pubmed

Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif.

TRAF6 CD40

1.42e-05542210075662
Pubmed

Agrin-Lrp4-Ror2 signaling regulates adult hippocampal neurogenesis in mice.

LRP4 AGRN

1.42e-05542231268420
Pubmed

Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding.

LRP4 LRP6

1.42e-05542216263759
Pubmed

structural Studies of Wnts and identification of an LRP6 binding site.

LRP6 WNT3A

1.42e-05542223791946
Pubmed

Capturing genes encoding membrane and secreted proteins important for mouse development.

LRP6 AGRN

1.42e-0554227604039
Pubmed

β-arrestin promotes Wnt-induced low density lipoprotein receptor-related protein 6 (Lrp6) phosphorylation via increased membrane recruitment of Amer1 protein.

LRP6 WNT3A

1.42e-05542224265322
Pubmed

Helicobacter pylori-induced activation of beta-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled.

LRP6 WNT3A

1.42e-05542220137080
Pubmed

TRAF6 is required for generation of the B-1a B cell compartment as well as T cell-dependent and -independent humoral immune responses.

TRAF6 CD40

1.42e-05542219270748
Pubmed

Wnt antagonists bind through a short peptide to the first β-propeller domain of LRP5/6.

LRP6 WNT3A

1.42e-05542221944579
Pubmed

LRP6 acts as a scaffold protein in cardiac gap junction assembly.

LRP6 GJA5

1.42e-05542227250245
Pubmed

Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40.

TRAF6 CD40

1.42e-0554229990007
Pubmed

Negative regulation of CD40-mediated B cell responses by E3 ubiquitin ligase Casitas-B-lineage lymphoma protein-B.

TRAF6 CD40

1.42e-05542217878343
Pubmed

A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling.

LRP6 WNT3A

1.42e-05542212121999
Pubmed

A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation.

TRAF6 CD40

2.13e-05642211406619
Pubmed

TNF receptor-associated factor 6-dependent CD40 signaling primes macrophages to acquire antimicrobial activity in response to TNF-alpha.

TRAF6 CD40

2.13e-05642216237096
Pubmed

Tumor necrosis factor receptor-associated factor 2 (TRAF2)-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling.

TRAF6 CD40

2.13e-05642212958312
Pubmed

Differential TRAF3 utilization by a variant human CD40 receptor with enhanced signaling.

TRAF6 CD40

2.13e-05642221041727
Pubmed

MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1.

TRAF6 CD40

2.13e-0564229020361
Pubmed

N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation.

LRP6 WNT3A

2.13e-05642219075000
Pubmed

Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling.

LRP6 WNT3A

2.13e-05642220093472
Pubmed

Wnt/Lrp/beta-catenin signaling suppresses adipogenesis by inhibiting mutual activation of PPARgamma and C/EBPalpha.

LRP6 WNT3A

2.13e-05642217888405
Pubmed

Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival.

LAMA5 AGRN

2.13e-05642223847204
Pubmed

Laminin alpha1 globular domains 4-5 induce fetal development but are not vital for embryonic basement membrane assembly.

LAMA5 AGRN

2.13e-05642215668394
Pubmed

Balancing WNT signalling in early forebrain development: The role of LRP4 as a modulator of LRP6 function.

LRP4 LRP6

2.13e-05642237091972
Pubmed

Lrp4 is a receptor for Agrin and forms a complex with MuSK.

LRP4 AGRN

2.98e-05742218848351
Pubmed

The MuSK activator agrin has a separate role essential for postnatal maintenance of neuromuscular synapses.

LRP4 AGRN

2.98e-05742225368159
Pubmed

RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis.

LRP4 LRP6

2.98e-05742234847079
Pubmed

CD40-dependent activation of phosphatidylinositol 3-kinase/Akt pathway mediates endothelial cell survival and in vitro angiogenesis.

TRAF6 CD40

2.98e-05742212637493
Pubmed

CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization.

TRAF6 CD40

2.98e-0574229718306
Pubmed

Preferential expression of connexin37 and connexin40 in the endothelium of the portal veins during mouse liver development.

GJA5 VWF

3.97e-05842216505993
Pubmed

Blood flow reprograms lymphatic vessels to blood vessels.

GJA5 VWF

3.97e-05842222622036
Pubmed

Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6.

LRP6 WNT3A

3.97e-05842220093360
Pubmed

CD40-mediated tumor necrosis factor receptor-associated factor 3 signaling upregulates IL-4-induced germline Cepsilon transcription in a human B cell line.

TRAF6 CD40

3.97e-05842212220533
Pubmed

Agrin acts via a MuSK receptor complex.

LRP4 AGRN

3.97e-0584228653787
Pubmed

Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and developmental defects.

TRPM6 SLC41A1

3.97e-05842233859252
Pubmed

LRP4 serves as a coreceptor of agrin.

LRP4 AGRN

3.97e-05842218957220
Pubmed

TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation.

TRAF6 CD40

3.97e-05842210764746
Pubmed

RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase.

TRAF6 CD40

3.97e-0584229642260
Pubmed

Fras1 deficiency results in cryptophthalmos, renal agenesis and blebbed phenotype in mice.

LAMA5 AGRN

3.97e-05842212766770
Pubmed

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.

LAMA5 VWF HMCN1 AGRN

4.98e-0516742422159717
InteractionHOXA1 interactions

LAMA5 TGM7 VWF AGRN KRTAP1-5 KRTAP1-1 KRTAP1-3

6.78e-06356417int:HOXA1
InteractionCRH interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3

1.17e-0522413int:CRH
InteractionCLDN2 interactions

WNK4 KRTAP1-1 KRTAP1-3

3.38e-0531413int:CLDN2
InteractionWNT11 interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3

4.89e-0535413int:WNT11
InteractionEDN3 interactions

TNFRSF6B LAMA5 LRP6 AGRN

6.78e-05108414int:EDN3
InteractionCFC1 interactions

TNFRSF6B LAMA5 LRP6 AGRN

1.23e-04126414int:CFC1
InteractionLRP6 interactions

LRP4 LRP6 TRAF6 WNT3A

1.31e-04128414int:LRP6
InteractionBCAM interactions

LAMA5 KRTAP1-1 KRTAP1-3

1.43e-0450413int:BCAM
InteractionNUFIP2 interactions

VWF AGRN KRTAP1-5 KRTAP1-1 KRTAP1-3 STAB1

1.84e-04417416int:NUFIP2
InteractionGLYAT interactions

KRTAP1-1 KRTAP1-3

2.20e-0411412int:GLYAT
InteractionKRTAP9-2 interactions

CTRC KRTAP1-5 KRTAP1-1 KRTAP1-3

2.35e-04149414int:KRTAP9-2
InteractionLCE3E interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3

2.47e-0460413int:LCE3E
InteractionKRTAP5-4 interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3

2.85e-0463413int:KRTAP5-4
InteractionVSTM4 interactions

KRTAP1-1 KRTAP1-3

3.11e-0413412int:VSTM4
InteractionKRTAP5-11 interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3

3.27e-0466413int:KRTAP5-11
InteractionPHLDA1 interactions

TRAF6 KRTAP1-1 KRTAP1-3

3.27e-0466413int:PHLDA1
InteractionKRTAP5-3 interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3

3.27e-0466413int:KRTAP5-3
InteractionCREB5 interactions

AGRN KRTAP1-5 KRTAP1-1 KRTAP1-3

3.39e-04164414int:CREB5
InteractionLCE1E interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3

3.57e-0468413int:LCE1E
InteractionLCE2A interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3

3.73e-0469413int:LCE2A
InteractionLCE1D interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3

3.89e-0470413int:LCE1D
InteractionSLC43A2 interactions

KRTAP1-1 KRTAP1-3

4.17e-0415412int:SLC43A2
InteractionLCE3D interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3

4.40e-0473413int:LCE3D
InteractionMAPKBP1 interactions

TRAF6 KRTAP1-1 KRTAP1-3

4.58e-0474413int:MAPKBP1
InteractionLCE2D interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3

4.58e-0474413int:LCE2D
InteractionSDF2L1 interactions

TNFRSF6B LAMA5 LRP6 AGRN WNT3A

4.72e-04322415int:SDF2L1
InteractionWNT1 interactions

LRP6 WNT3A

4.76e-0416412int:WNT1
InteractionIGFL3 interactions

LRP4 LAMA5 AGRN

4.77e-0475413int:IGFL3
InteractionKRTAP4-5 interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3

4.96e-0476413int:KRTAP4-5
InteractionLCE3A interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3

4.96e-0476413int:LCE3A
InteractionSMCP interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3

5.55e-0479413int:SMCP
InteractionLCE4A interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3

5.76e-0480413int:LCE4A
InteractionKRTAP4-4 interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3

5.97e-0481413int:KRTAP4-4
InteractionLCE2B interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3

5.97e-0481413int:LCE2B
InteractionPI15 interactions

LAMA5 LRP6 AGRN

6.41e-0483413int:PI15
InteractionLCE1A interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3

6.64e-0484413int:LCE1A
InteractionZNF383 interactions

LRP4 LRP6

6.76e-0419412int:ZNF383
InteractionNMU interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3

6.88e-0485413int:NMU
InteractionLCE1B interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3

6.88e-0485413int:LCE1B
InteractionNID2 interactions

LAMA5 AGRN KRTAP1-3

7.11e-0486413int:NID2
InteractionDMRT3 interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3

7.36e-0487413int:DMRT3
InteractionZNF446 interactions

ZNF576 KRTAP1-1 KRTAP1-3

7.61e-0488413int:ZNF446
InteractionLCE2C interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3

7.61e-0488413int:LCE2C
InteractionLCE5A interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3

8.12e-0490413int:LCE5A
InteractionZNF786 interactions

KRTAP1-1 KRTAP1-3

8.27e-0421412int:ZNF786
InteractionCTRC interactions

CTRC KRTAP1-1

8.27e-0421412int:CTRC
InteractionELSPBP1 interactions

TNFRSF6B LAMA5 AGRN

8.66e-0492413int:ELSPBP1
InteractionLCE1F interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3

8.66e-0492413int:LCE1F
InteractionKRTAP4-11 interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3

8.66e-0492413int:KRTAP4-11
InteractionCHRD interactions

LYPD6B KRTAP1-1 KRTAP1-3

9.21e-0494413int:CHRD
InteractionKRTAP5-6 interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3

9.21e-0494413int:KRTAP5-6
InteractionCHRNG interactions

KRTAP1-1 KRTAP1-3

9.94e-0423412int:CHRNG
InteractionSHFL interactions

KRTAP1-5 KRTAP1-1 KRTAP1-3

1.01e-0397413int:SHFL
InteractionOLFM2 interactions

CGA KRTAP1-1 KRTAP1-3

1.01e-0397413int:OLFM2
InteractionZDHHC1 interactions

KRTAP1-1 KRTAP1-3

1.18e-0325412int:ZDHHC1
InteractionSLC23A1 interactions

KRTAP1-1 KRTAP1-3

1.27e-0326412int:SLC23A1
InteractionPRKAB2 interactions

TGM7 PRKAG2 KRTAP1-1 KRTAP1-3

1.28e-03234414int:PRKAB2
InteractionLRP5 interactions

LRP4 LRP6 TRAF6

1.41e-03109413int:LRP5
InteractionFEZF1 interactions

LRP4 KRTAP1-1

1.48e-0328412int:FEZF1
InteractionMAP3K8 interactions

TRAF6 CD40

1.48e-0328412int:MAP3K8
InteractionSPRY1 interactions

TGM7 KRTAP1-1 KRTAP1-3

1.49e-03111413int:SPRY1
Cytoband17q12-q21

KRTAP1-5 KRTAP1-3

3.98e-043242217q12-q21
CytobandEnsembl 112 genes in cytogenetic band chr17q21

WNK4 KRTAP1-5 KRTAP1-1 KRTAP1-3

9.14e-04473424chr17q21
CytobandEnsembl 112 genes in cytogenetic band chr20q13

TNFRSF6B LAMA5 CD40

6.79e-03422423chr20q13
GeneFamilyLow density lipoprotein receptors

LRP4 LRP6

2.64e-0413342634
GeneFamilyKeratin associated proteins

KRTAP1-5 KRTAP1-1 KRTAP1-3

1.11e-03109343619
GeneFamilyCD molecules|Tumor necrosis factor receptor superfamily|Death inducing signaling complex

TNFRSF6B CD40

1.35e-0329342782
CoexpressionNABA_ECM_GLYCOPROTEINS

LAMA5 VWF HMCN1 OTOGL AGRN

1.33e-05191425MM17059
CoexpressionNABA_ECM_GLYCOPROTEINS

LAMA5 VWF HMCN1 AGRN FBN3

1.51e-05196425M3008
CoexpressionNABA_BASEMENT_MEMBRANES

LAMA5 HMCN1 AGRN

3.63e-0540423M5887
CoexpressionNABA_CORE_MATRISOME

LAMA5 VWF HMCN1 OTOGL AGRN

6.96e-05270425MM17057
CoexpressionNABA_CORE_MATRISOME

LAMA5 VWF HMCN1 AGRN FBN3

7.59e-05275425M5884
ToppCellfacs-Aorta-Heart-3m-Endothelial-endocardial_endothelial_cells|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GJA5 VWF OTOGL WNK4 STAB1

5.05e-07167425a4a795751644b22af616335379e64ae95175180c
ToppCellfacs-Heart-LV-3m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF HMCN1 OTOGL WNK4 STAB1

5.84e-07172425f2c17c49b375b28ad47dc6cabda62f1c238023dd
ToppCellfacs-Heart-LV-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF HMCN1 OTOGL WNK4 STAB1

5.84e-071724256ab4f01098dddb789df298ddf97b3c384405ee6c
ToppCellfacs-Heart-LA-3m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC44A2 VWF HMCN1 WNK4 STAB1

1.01e-0619242514a816ef116aa992f86edab411f043cf7d07fe04
ToppCellfacs-Heart-LA-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC44A2 VWF HMCN1 WNK4 STAB1

1.01e-06192425847822514d747a21d5eb40e04ba9a023fd32bd65
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TRPM6 USP31 LAMA5 LYPD6B WNT3A

1.17e-061984255374b0e98d669f36a0571d3c006c7bd5e3c8e87f
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_basal-Basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TRPM6 USP31 LAMA5 LYPD6B WNT3A

1.20e-0619942594a7867e800df352731796de8c24cba133c29622
ToppCell343B-Epithelial_cells-Epithelial-E_(AT2)|343B / Donor, Lineage, Cell class and subclass (all cells)

LAMA5 LRP6 MALRD1 FBN3

1.05e-05145424cb534333fba44b241b14fb0d7b74e843f4e7f9f8
ToppCell343B-Epithelial_cells-Epithelial-E_(AT2)-|343B / Donor, Lineage, Cell class and subclass (all cells)

LAMA5 LRP6 MALRD1 FBN3

1.05e-0514542480684ec249fa445c1b35f94608a4a6824d53f2d9
ToppCell343B-Epithelial_cells-Epithelial-H_(AT1)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

UGT1A1 LRP4 HMCN1 WNT3A

1.59e-05161424da9eecf919866a9c579d7a707a996cf335213134
ToppCell343B-Epithelial_cells-Epithelial-H_(AT1)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

UGT1A1 LRP4 HMCN1 WNT3A

1.59e-05161424d431625c32f59a6b552191f3adc5198bd16ad5cf
ToppCellAdult-Endothelial-endothelial_cell_of_artery-D231|Adult / Lineage, Cell type, age group and donor

KCNH6 GJA5 VWF NR1H4

1.88e-05168424aca34c51758c65925ad24110294a72b2dea6db72
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM6 LRP6 HMCN1 WNK4

2.11e-051734240c74bdb40e635d906fd180412c23bf7fed61621e
ToppCellfacs-Pancreas-Exocrine-18m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTRC LRP4 SLC41A1 AGRN

2.21e-051754243f1b2e23fec953148fb0711e523c463adb07dca4
ToppCellAT1_cells-HP_01|World / lung cells shred on cell class, cell subclass, sample id

LAMA5 TDRD5 AGRN WNT3A

2.26e-05176424458720776b0151cd55acc352d509599cb62f0ca8
ToppCellfacs-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GJA5 VWF WNK4 STAB1

2.36e-051784249f59a9af232d77bb55603a7776dbf9749ea652f2
ToppCelldroplet-Lung-LUNG-30m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA5 GJA5 VWF STAB1

2.41e-05179424a09647750eba9d93c5efc1db3b555fefb5eec7b5
ToppCellfacs-Pancreas-Exocrine-18m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTRC LRP4 SLC41A1 AGRN

2.41e-05179424bbfbfb32773346080127055b5aafa36bbf7d0942
ToppCellPCW_05-06-Endothelial-Endothelial_mature-endo_arterial_(9)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

GJA5 VWF STAB1 CD40

2.46e-051804245861b44acfb8fe92c281c8355bf19c059b3dcd64
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LAMA5 GJA5 VWF STAB1

2.63e-051834246f8f997ffc9eaebca2683de125b6069d07c07d26
ToppCell5'-Adult-LymphNode-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TNFRSF6B LAMA5 VWF STAB1

2.63e-05183424a644258ba90acc62d571623e429d72ffc4b69203
ToppCelldroplet-Heart-4Chambers-18m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF HMCN1 AGRN STAB1

2.63e-051834246c4a09c02e30e1f24dde39f8cb8c5b453826ee2e
ToppCellfacs-Brain_Myeloid-Cortex|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC44A2 VWF NR1H4 STAB1

2.68e-0518442417f63dd671f9ff3dd2860d8de41b05c35c095950
ToppCellAdult-Endothelial-endothelial_cell_of_artery|Adult / Lineage, Cell type, age group and donor

KCNH6 GJA5 VWF HMCN1

2.80e-051864242d1c4ea2e401db89971582ee54618a8b0c81b8ac
ToppCellfacs-Heart-LA-24m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF HMCN1 WNK4 STAB1

2.86e-051874247b13c3b67d66f3afb410141d5471c9e78a4d8623
ToppCellAT1_cells-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

LAMA5 AGRN FBN3 WNT3A

2.86e-05187424f1dda349335e08dbfc8395d373924037f5ad2fd6
ToppCellfacs-Heart-LA-24m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF HMCN1 WNK4 STAB1

2.86e-05187424d9943e65eedab73d141eae524e2411653a751705
ToppCellfacs-Heart-RA-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF HMCN1 WNK4 STAB1

2.92e-051884244ddb11a90bf3baa7237bde304db44dfcc56aed52
ToppCellfacs-Heart-RA-3m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF HMCN1 WNK4 STAB1

2.92e-05188424e47e66906922d5c69b1aafe28face0787d3fc563
ToppCellE17.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

GJA5 VWF HMCN1 AGRN

2.92e-0518842459f276e23c8380bae57d7ecca3a8b83df4bc150b
ToppCelldroplet-Lung-nan-18m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA5 GJA5 VWF AGRN

2.92e-05188424405efea75233ecf70f7d19b630230798d817b7f2
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM6 MALRD1 HMCN1 WNK4

2.98e-05189424f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCelldroplet-Heart-nan-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF HMCN1 WNK4 STAB1

2.98e-051894248e583ec4df0f5b79ce5211cc99ecd8616d180bde
ToppCelldroplet-Heart-nan-24m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF HMCN1 WNK4 STAB1

2.98e-051894241137583e21d874c201c20581ba1995e2bfa3de59
ToppCelldroplet-Heart-nan-3m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF HMCN1 WNK4 STAB1

2.98e-05189424fb2253b8463d08b3d28e952a31a23dea2c2d986b
ToppCelldroplet-Heart-nan-24m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF HMCN1 WNK4 STAB1

3.04e-051904247068754c29f63a331e2b6c54715f3b26f37ad32b
ToppCelldroplet-Heart-4Chambers-18m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF HMCN1 WNK4 STAB1

3.04e-051904246f71a9f74af7cd9a674753cfc9833ebe5bba0fa2
ToppCellE16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal|E16.5-samps / Age Group, Lineage, Cell class and subclass

LRP4 GJA5 ZEB2 CD40

3.10e-051914243379d145d34f89150f7b06d1340022cfc6b4a6ce
ToppCellfacs-Heart-RV-3m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF HMCN1 WNK4 STAB1

3.10e-05191424e518c598719119e60c76016c586b1520c258bbcb
ToppCellfacs-Heart-RV-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF HMCN1 WNK4 STAB1

3.10e-05191424f0c649bb32732c9dd38a0af8ce94d2a4d16de39a
ToppCelldroplet-Heart-nan-18m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF HMCN1 WNK4 STAB1

3.17e-051924240b9b2eaed45456d7d74ce78a64ef4a26ac2458fb
ToppCellfacs-MAT-Fat-3m-Endothelial-endothelial_cell|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA5 GJA5 VWF STAB1

3.23e-05193424e164f6403a8b541ced08a6feec915d2e855036ea
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Vein|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TNFRSF6B VWF HMCN1 STAB1

3.23e-051934247261c1ce30c796b61c6ec58e64a051baa24732ff
ToppCellfacs-MAT-Fat-3m-Endothelial|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA5 GJA5 VWF STAB1

3.23e-05193424b32533afeff1905e188becaa09079e9699722e4b
ToppCellfacs-MAT-Fat-3m-Endothelial-nan|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA5 GJA5 VWF STAB1

3.23e-051934242ff573ba2c74583ed1cb071a3bbc01bb71117e5f
ToppCelldroplet-Heart-4Chambers-21m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF HMCN1 WNK4 STAB1

3.30e-05194424c5e77650d7abee339ec38fa78a622bb124db3fa5
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)-D231|Adult / Lineage, Cell type, age group and donor

PRKAG2 SH2B3 ZEB2 STAB1

3.30e-05194424800d3d7a9e864d2d6a100a4e4af22f45d5790a8d
ToppCellwk_20-22-Endothelial-Blood_vessel_endothelial-GRIA2+_arterial_endo|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

LRP6 GJA5 VWF AGRN

3.37e-05195424a432d69b0172211ee4d53675936a1dc9ce1ae1f0
ToppCell356C-Epithelial_cells-Epithelial-I_(AT1)-|356C / Donor, Lineage, Cell class and subclass (all cells)

LAMA5 AGRN FBN3 WNT3A

3.37e-05195424b65511770ed67f7447847e2187555b362988af45
ToppCell356C-Epithelial_cells-Epithelial-I_(AT1)|356C / Donor, Lineage, Cell class and subclass (all cells)

LAMA5 AGRN FBN3 WNT3A

3.37e-0519542407a3ef6b0f1201fe2bcb9ea426b8f7a69beb4904
ToppCelldroplet-Heart-4Chambers-21m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF HMCN1 WNK4 STAB1

3.37e-05195424df644b4c3ddccd34614ece5a2378000e6bc0fa10
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF HMCN1 WNK4 STAB1

3.43e-051964247d5eaed189aa6116f3799be010139fb675ec65e0
ToppCelldroplet-Heart-nan-18m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF HMCN1 WNK4 STAB1

3.43e-05196424e386526332138e636aef2542c11316347a45689c
ToppCell(7)_Epithelial-I_(AT1)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

LAMA5 AGRN FBN3 WNT3A

3.43e-05196424150554fa06868d29b0608189862eef6505ba757f
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM6 AGRN WNK4 CGA

3.43e-05196424f40d10ea7714067585493fdc89744714aa427de8
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF HMCN1 WNK4 STAB1

3.43e-05196424dbf154b3d166ffd07be717dac8d8a3350ac63e16
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Degenerative_Distal_Convoluted_Tubule_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM6 AGRN WNK4 CGA

3.43e-05196424b8350340d86e4524e9616a427e7f2e116a6fb3be
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_dendritic-myeloid_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CTRC SH2B3 ZEB2 STAB1

3.50e-051974249838dbd1623babf8de7e9126a28fe5d3666bce42
ToppCellTracheal-NucSeq-Immune_Myeloid-Monocytic-Monocyte_CD14|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ZNF576 SH2B3 ZEB2 STAB1

3.64e-051994241413156b7be5373fd02bbe39ec50ccfe165fa6d1
ToppCell(7)_Epithelial_cells-(7)_Epithelial-I_(AT1)|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

LAMA5 AGRN FBN3 WNT3A

3.64e-051994245a002d49a8b84c158f7b4d7a3e78e6a937757bb7
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TNFRSF6B VWF HMCN1 AGRN

3.64e-051994240602e2b2aa56d106da63bd342a38bef437b4d496
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Vein|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

TNFRSF6B VWF HMCN1 STAB1

3.72e-052004247eb366b2c5394af7c77650bde6261e7dac67154e
ToppCellLPS_anti-TNF-Hematopoietic_Myeloid-Granulocytic_cells-Mast-cells|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

TRPM6 LRP4 SH2B3 STAB1

3.72e-052004240b02f3ca3d8612ed7af46381195b0ed5591313cf
ToppCellTracheal-NucSeq-Immune_Myeloid-Monocytic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ZNF576 SH2B3 ZEB2 STAB1

3.72e-0520042448ce43a27e78b2883e588e1a63fa5352c2deeeb7
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Pericyte-Pericyte_2|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

LRP6 DRD1 ZEB2 NR1H4

3.72e-05200424cf883ba5dbe6350b93142d625a52b25ff2a8bb63
ToppCellLPS_only-Endothelial-Endothelial-Artery|LPS_only / Treatment groups by lineage, cell group, cell type

TNFRSF6B GJA5 VWF HMCN1

3.72e-05200424b17eb1587ca86c3d40515128a00a8d8fd787fccf
ToppCellCerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lrg1_(Lrg1)--|Cerebellum / BrainAtlas - Mouse McCarroll V32

TRPM6 VWF CD40

6.60e-05834233aa95bf2d8ac37e648037faf3d54ebb243a4fde1
ToppCellCerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lrg1_(Lrg1)-|Cerebellum / BrainAtlas - Mouse McCarroll V32

TRPM6 VWF CD40

6.60e-058342370804dd63221dd5ed26068ec1b50f11875abbc50
ToppCellCerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lrg1_(Lrg1)|Cerebellum / BrainAtlas - Mouse McCarroll V32

TRPM6 VWF CD40

6.60e-0583423c1818411438f53aec76afead5c8caab701b95d39
ToppCellCerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_2|Cerebellum / BrainAtlas - Mouse McCarroll V32

TRPM6 VWF CD40

6.60e-05834231e7af8aaa20b4c2a77cf2f330113db0faa9d483c
ToppCellfacs-Aorta-Heart-3m-Endothelial-coronary_vascular_endothelial_cell|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MPO TGM7 WNT3A

2.61e-04132423dc13b54e38fbda9341972cef11833041f2f2a345
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MPO TRPM6 HMCN1

2.91e-0413742385b3a98039c1f68addad0334aa5b2584f6045aaa
ToppCellStriatum-Endothelial-ENDOTHELIAL_STALK|Striatum / BrainAtlas - Mouse McCarroll V32

VWF HMCN1 CD40

2.91e-04137423d37f425b13bc046baa1f8619b98a16b936f88ff6
ToppCellStriatum-Endothelial-ENDOTHELIAL_STALK-Flt1_1|Striatum / BrainAtlas - Mouse McCarroll V32

VWF HMCN1 CD40

2.91e-04137423306b11b3b9e5fd562d845fb5eaa4ac982864efce
ToppCellfacs-Heart-Unknown-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGM7 OTOGL WNK4

3.23e-04142423759fbbd15b4fb313bd6269b7f087edafebd530ef
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-6|TCGA-Skin / Sample_Type by Project: Shred V9

KRTAP1-5 KRTAP1-1 KRTAP1-3

3.50e-04146423522c32103c24fc26836bb5b642083904682d9292
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial-oligodendrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MPO TDRD5 ZEB2

3.79e-04150423afd651c654e715414eff64cf3a37378d057a56a2
ToppCellE17.5-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

LRP4 LAMA5 WNT3A

3.79e-04150423201d5b68e71c6c003285428be96c488e6d526edf
ToppCellnormal_Lymph_Node-Myeloid_cells-mo-Mac|Myeloid_cells / Location, Cell class and cell subclass

SH2B3 ZEB2 STAB1

4.02e-041534235424494ea1f09542799045a875cc3eac13de5079
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GJA5 DRD1 VWF

4.09e-04154423e51a5114f0ec38f997f5b8bbf3a7770f98595474
ToppCellfacs-Liver-Non-hepatocytes-3m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TDRD5 KRTAP1-5 STAB1

4.17e-041554238fdda4e3657ac56188ae88ed3caf145f4d9d1567
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM6 HMCN1 WNK4

4.25e-041564234d2679e7639758c49fc25a2deb9109b08f0a3e57
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBXL18 HMCN1 AGRN

4.33e-04157423beab0ac47202266b04543c02cfcdda012375e879
ToppCell343B-Epithelial_cells-Epithelial-H_(AT1)-|343B / Donor, Lineage, Cell class and subclass (all cells)

UGT1A1 OTOGL WNT3A

4.33e-04157423dd08dc19d434e94a194076c462ee273c682abf55
ToppCell343B-Epithelial_cells-Epithelial-H_(AT1)|343B / Donor, Lineage, Cell class and subclass (all cells)

UGT1A1 OTOGL WNT3A

4.33e-0415742370fd6c46db4250c7de5c4686a9500689402737f6
ToppCellTransplant_Alveoli_and_parenchyma-Epithelial-Type_1_alveolar|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

LAMA5 AGRN WNT3A

4.58e-0416042358ed3a074932ccc951e07868dfdc61b99ae1cc2b
ToppCelldroplet-Limb_Muscle-nan-24m-Myeloid-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNH6 LYPD6B IL1RL2

4.58e-04160423984990be02642a562f0c60ea99c01f005e7c02c2
ToppCellfacs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UGT1A1 OTOGL AGRN

4.58e-04160423bb1b966fb9e801db15e67d03e49db4609d6f935a
ToppCellfacs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UGT1A1 OTOGL AGRN

4.58e-0416042356e6f4b82b5dc41c45f9d253c2db314a6f702b84
ToppCellfacs-Marrow-Granulocytes-18m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UGT1A1 OTOGL AGRN

4.66e-0416142360f433eab9d5531bdf6aa86b0265f20b866b904c
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM6 HMCN1 WNK4

4.75e-0416242336ddebe3bb172c992739353b7b049b2dde98b559
ToppCellBronchial-NucSeq-Endothelial-Endothelia_vascular-VE_systemic_arterial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

VWF HMCN1 CD40

4.92e-041644233cd80e6275f0f9b5667912139d15ebf5e6b17f2f
ToppCellfrontal_cortex-Non-neuronal-endothelial_cell|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

VWF HMCN1 CD40

4.92e-041644236a41a159134e605b80d5e731f9ed5bc803bb531b
ToppCellfrontal_cortex-Non-neuronal-endothelial_cell-Endo|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

VWF HMCN1 CD40

4.92e-04164423ec68954fc09b6850273b5e59caa6b09d02151097
ToppCellCerebellum-Endothelial-ENDOTHELIAL_STALK|Cerebellum / BrainAtlas - Mouse McCarroll V32

VWF HMCN1 CD40

5.01e-041654237d319a112b9062efee428bef6f4534d2ce782e04
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L5-6_THEMIS_OR1J1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PRKAG2 KRTAP1-5 KRTAP1-1

5.01e-041654231f88f6939f88b80a0c98b4eef3684ba03c64ff7c
ToppCellPCW_07-8.5-Hematologic_ErythroMegGranulo-Hem_Granulocytic-im_mast/basophil_(18)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

MPO CGA STAB1

5.09e-04166423f03f78cae6272c89618c0bda032ce45c4fc96baa
ToppCellfrontal_cortex-Non-neuronal-endothelial_cell-Endo-Endo_Ctla2a|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

VWF HMCN1 CD40

5.09e-0416642327af6c906cff1d40d134f0386db7708869691121
ToppCellE16.5-Endothelial-Endothelial_lymphatic|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SLC41A1 HMCN1 STAB1

5.18e-04167423b93103a868fba63a8910bffb690a6242b9252833
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM6 GJA5 CD40

5.18e-04167423b4ef07117d14da3d5fbced949e4dfcb01c392295
Drugethylnylestradiol

MPO UGT1A1 LRP4 LRP6 GJA5 DRD1 VWF NR1H4 KRTAP1-5 CGA KRTAP1-1 KRTAP1-3 CD40

2.24e-0712514213CID000003285
Drugboldine

UGT1A1 DRD1 NR1H4

6.94e-0710423ctd:C011686
Drugcopper(II) sulfate pentahydrate; Up 200; 100uM; MCF7; HG-U133A

ZNF576 LRP6 GJA5 TRAF6 PRKAG2 CGA

1.57e-06197426575_UP
Drugxanthohumol

UGT1A1 TRAF6 VWF NR1H4

2.96e-0654424ctd:C104536
Drugsulfur mustard

LAMA5 KRTAP1-5 PARP3 KRTAP1-1 KRTAP1-3

4.03e-06130425CID000010461
DrugHdba

MPO KCNH6 GJA5

5.54e-0619423CID000003896
Drug4-(4-(2,3-dihydrobenzo(1,4)dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide

LRP6 WNT3A

9.95e-063422ctd:C493177
DrugGlafenine hydrochloride [65513-72-6]; Up 200; 9.8uM; MCF7; HT_HG-U133A

TNFRSF6B LAMA5 LRP6 PRKAG2 SH2B3

3.10e-051984257018_UP
DrugKarakoline [39089-30-0]; Up 200; 10.6uM; PC3; HT_HG-U133A

KCNH6 AGRN PARP3 STAB1 CD40

3.17e-051994254297_UP
Diseasevenous thromboembolism, fibrinogen measurement

SLC44A2 LRP4 VWF SH2B3

1.88e-0667394EFO_0004286, EFO_0004623
Diseasevenous thromboembolism, tissue plasminogen activator measurement

SLC44A2 LRP4 VWF

3.71e-0623393EFO_0004286, EFO_0004791
Diseasefactor XI measurement, venous thromboembolism

SLC44A2 LRP4 VWF

8.46e-0630393EFO_0004286, EFO_0004694
Diseasefactor VIII measurement, venous thromboembolism

SLC44A2 LRP4 VWF

1.24e-0534393EFO_0004286, EFO_0004630
Diseaseend stage renal disease (is_implicated_in)

MPO VWF CD40

2.20e-0541393DOID:783 (is_implicated_in)
Diseaseessential thrombocythemia (is_implicated_in)

VWF SH2B3

2.54e-056392DOID:2224 (is_implicated_in)
Diseaseatrial fibrillation (is_implicated_in)

GJA5 VWF

1.53e-0414392DOID:0060224 (is_implicated_in)
Diseaseglycerate measurement

HMCN1 AGRN

1.77e-0415392EFO_0021029
DiseaseMyasthenic Syndromes, Congenital, Slow Channel

LRP4 AGRN

2.02e-0416392C0751885
DiseaseCongenital Myasthenic Syndromes, Postsynaptic

LRP4 AGRN

2.29e-0417392C0751883
DiseaseCongenital Myasthenic Syndromes, Presynaptic

LRP4 AGRN

2.87e-0419392C0751884
Diseaserenovascular hypertension (biomarker_via_orthology)

MPO GJA5

2.87e-0419392DOID:1591 (biomarker_via_orthology)
Diseasetype 1 diabetes mellitus (biomarker_via_orthology)

UGT1A1 VWF

2.87e-0419392DOID:9744 (biomarker_via_orthology)
Diseasefactor VIII measurement, Ischemic stroke

VWF SH2B3

2.87e-0419392EFO_0004630, HP_0002140
Diseasevenous thromboembolism, plasminogen activator inhibitor 1 measurement

SLC44A2 VWF

3.52e-0421392EFO_0004286, EFO_0004792
Diseasenose morphology measurement, mouth morphology measurement

FBN3 CD40

3.52e-0421392EFO_0007843, EFO_0007955
DiseaseMyasthenic Syndromes, Congenital

LRP4 AGRN

4.61e-0424392C0751882
DiseaseInflammation

MPO SH2B3 NR1H4

6.35e-04127393C0021368
DiseaseCrohn's disease (is_implicated_in)

UGT1A1 CD40

7.23e-0430392DOID:8778 (is_implicated_in)
DiseaseIschemic stroke, von Willebrand factor measurement

VWF SH2B3

7.23e-0430392EFO_0004629, HP_0002140
DiseaseHirschsprung Disease

ZEB2 WNT3A

7.73e-0431392C0019569
Diseaseviral load

TRPM6 LRP4 FBN3

7.75e-04136393EFO_0010125
Diseaseatrial fibrillation (is_marker_for)

GJA5 CD40

8.23e-0432392DOID:0060224 (is_marker_for)
Diseaseobesity (biomarker_via_orthology)

GJA5 DRD1 NR1H4

9.71e-04147393DOID:9970 (biomarker_via_orthology)
DiseaseCardiovascular Diseases

MPO VWF

1.04e-0336392C0007222
Diseasemultiple sclerosis

MPO SLC44A2 USP31 SH2B3 CD40

1.06e-03594395MONDO_0005301
DiseaseParoxysmal atrial fibrillation

GJA5 VWF CGA

1.15e-03156393C0235480
Diseasefamilial atrial fibrillation

GJA5 VWF CGA

1.15e-03156393C3468561
DiseasePersistent atrial fibrillation

GJA5 VWF CGA

1.15e-03156393C2585653
Diseasevenous thromboembolism, factor VII measurement

SLC44A2 VWF

1.16e-0338392EFO_0004286, EFO_0004619
Disease3-hydroxypropylmercapturic acid measurement

TRPM6 USP31 TRAF6 VWF

1.18e-03352394EFO_0007014
DiseaseAtrial Fibrillation

GJA5 VWF CGA

1.24e-03160393C0004238
Diseasemyocardial infarction (biomarker_via_orthology)

GJA5 VWF ZEB2

1.24e-03160393DOID:5844 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
GFPVAKPCFSQPTSN

TDRD5

231

Q8NAT2
SPPDTGQRFCPSSFQ

PRKAG2

196

Q9UGJ0
DFSCQSVPGSPVCGS

AGRN

706

O00468
PFCGSGETQPFCIDS

DRD1

296

P21728
TNSPGSFQCLCPPGF

FBN3

1986

Q75N90
PIQISPHCSCTPSGF

NR1H4

11

Q96RI1
QGQPVPCPEFSSSTF

PARP3

496

Q9Y6F1
QQPCTCDFLTGPNTP

KCNH6

61

Q9H252
PFFRSCPACPGSNIT

MPO

311

P05164
LSCGEPPTCSPQQFT

LRP6

1241

O75581
PPTCSPQQFTCFTGE

LRP6

1246

O75581
QPSCCQTSFCGFPSF

KRTAP1-1

46

Q07627
QPSCCQTSFCGFPSF

KRTAP1-3

36

Q8IUG1
QPRSCQTSFCGFPSF

KRTAP1-5

36

Q9BYS1
VSCPCPLSVPSNNFA

LAMA5

1911

O15230
QCPSGFTLDSVGPFC

HMCN1

5091

Q96RW7
CPECTLQENPFFSQP

CGA

31

P01215
QPFAFNCTFPPITSG

IL1RL2

36

Q9HB29
VPVQPSPCEADQFSC

MALRD1

1896

Q5VYJ5
LACASSCGVPSFPPN

CTRC

11

Q99895
GIVQSCTPPPDFNQC

GJA5

256

P36382
GVCTDYSQCTQPCPP

ADGRF2

111

Q8IZF7
CPFTAKTCNPETFPS

SLC44A2

401

Q8IWA5
CVLTPSDFPNPCSSG

OTOGL

296

Q3ZCN5
PFCGPNTIPQFFCEI

OR10C1

166

Q96KK4
EPNNFISTYCCPEPS

RPP40

256

O75818
VQSCPSPFSGQACPQ

FBXL18

456

Q96ME1
SPFSGQACPQPSSVF

FBXL18

461

Q96ME1
RCPSPCTTFFSPDVN

SLC41A1

391

Q8IVJ1
DVCSSQPSCPPGSFL

TRPM6

1031

Q9BX84
PTLTNPGECRPNFTC

VWF

2346

P04275
PTAPIPCTFSTFGCH

TRAF6

236

Q9Y4K3
PCSLEFEATQCPNPF

UGT1A1

176

P22309
SQPPGSCNTVLFPFS

SH2B3

466

Q9UQQ2
SVPNPVFGSDTFCEP

STAB1

2536

Q9NY15
ASPNFCEPNPETGSF

WNT3A

276

P56704
TTAQPTFPCPDCGKT

ZNF576

106

Q9H609
PEGPSFPVCSTFVQE

USP31

266

Q70CQ4
FSCQFCKESFPGPIP

ZEB2

581

O60315
DPTPQQTSSGLFCCG

TGM7

361

Q96PF1
CSQVTLSSPFFPPCP

WNK4

896

Q96J92
TICEPCPVGFFSNVS

CD40

141

P25942
QNTQCQPCPPGTFSA

TNFRSF6B

146

O95407
LDPTPFPNSFKCFTC

LYPD6B

51

Q8NI32
PNPSGFSCTCPTGIN

LRP4

1021

O75096