Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentcalcium- and calmodulin-dependent protein kinase complex

CAMK2A CAMK2D CAMK2G

4.27e-0651593GO:0005954
DomainsrGAP2

SRGAP2 SRGAP2C SRGAP2B

5.50e-0731543IPR030252
DomainCaMKII_AD

CAMK2A CAMK2D CAMK2G

2.19e-0641543PF08332
DomainCa/CaM-dep_prot_kinase-assoc

CAMK2A CAMK2D CAMK2G

2.19e-0641543IPR013543
Domain-

CAMK2A CAMK2D CAMK2G

1.48e-041315433.10.450.50
DomainAdaptor_Cbl_EF_hand-like

CBL CBLB

2.02e-0431542IPR014741
DomainAdaptor_Cbl_SH2-like

CBL CBLB

2.02e-0431542IPR014742
DomainAdaptor_Cbl

CBL CBLB

2.02e-0431542IPR024162
DomainCbl_PTB

CBL CBLB

2.02e-0431542IPR024159
DomainDUF4071

MAP3K5 MAP3K15

2.02e-0431542PF13281
DomainANF_RECEPTORS

NPR1 NPR2

2.02e-0431542PS00458
DomainCbl_N2

CBL CBLB

2.02e-0431542PF02761
DomainCbl_N3

CBL CBLB

2.02e-0431542PF02762
DomainCbl_N

CBL CBLB

2.02e-0431542PF02262
DomainAdaptor_Cbl_N_hlx

CBL CBLB

2.02e-0431542IPR003153
DomainANPR/GUC

NPR1 NPR2

2.02e-0431542IPR001170
DomainCBL_PTB

CBL CBLB

2.02e-0431542PS51506
DomainDUF4071

MAP3K5 MAP3K15

2.02e-0431542IPR025136
Domain-

CBL CBLB

2.02e-04315421.20.930.20
DomainProt_kinase_dom

TLK2 NPR1 NPR2 CAMK2A CAMK2D CAMK2G RPS6KB2 NEK9 MAP3K5 JAK2 PRKCE MAP3K15 NEK11

2.12e-0448915413IPR000719
DomainPROTEIN_KINASE_DOM

TLK2 NPR1 NPR2 CAMK2A CAMK2D CAMK2G RPS6KB2 NEK9 MAP3K5 JAK2 PRKCE MAP3K15 NEK11

2.29e-0449315413PS50011
DomainNTF2-like_dom

CAMK2A CAMK2D CAMK2G

2.33e-04151543IPR032710
DomainANF_lig-bd_rcpt

NPR1 NPR2 CASR GRIN2C

2.38e-04371544IPR001828
DomainANF_receptor

NPR1 NPR2 CASR GRIN2C

2.38e-04371544PF01094
DomainPeripla_BP_I

NPR1 NPR2 CASR GRIN2C

2.92e-04391544IPR028082
DomainPkinase

TLK2 NPR2 CAMK2A CAMK2D CAMK2G RPS6KB2 NEK9 MAP3K5 PRKCE MAP3K15 NEK11

3.28e-0438115411PF00069
DomainKinase-like_dom

TLK2 NPR1 NPR2 CAMK2A CAMK2D CAMK2G RPS6KB2 NEK9 MAP3K5 JAK2 PRKCE MAP3K15 NEK11

5.64e-0454215413IPR011009
DomainFCH

SRGAP2 SRGAP2C SRGAP2B

7.55e-04221543PF00611
DomainFCH

SRGAP2 SRGAP2C SRGAP2B

7.55e-04221543SM00055
DomainSer/Thr_kinase_AS

TLK2 CAMK2A CAMK2D CAMK2G RPS6KB2 NEK9 MAP3K5 PRKCE MAP3K15 NEK11

7.73e-0435715410IPR008271
DomainS_TKc

TLK2 CAMK2A CAMK2D CAMK2G RPS6KB2 NEK9 MAP3K5 PRKCE MAP3K15 NEK11

8.07e-0435915410SM00220
DomainPROTEIN_KINASE_ST

TLK2 CAMK2A CAMK2D CAMK2G RPS6KB2 NEK9 MAP3K5 PRKCE MAP3K15 NEK11

8.59e-0436215410PS00108
DomainFCH_dom

SRGAP2 SRGAP2C SRGAP2B

8.63e-04231543IPR001060
DomainRCC1/BLIP-II

NEK9 TECPR2 HERC6

8.63e-04231543IPR009091
DomainBTB_2

KCNV2 KCNG1 KCTD15 KCNS1

9.51e-04531544PF02214
DomainT1-type_BTB

KCNV2 KCNG1 KCTD15 KCNS1

9.51e-04531544IPR003131
DomainSKP1/BTB/POZ

ZBTB6 KBTBD6 KCNV2 KBTBD7 KCNG1 KCTD15 KCNS1

9.89e-041891547IPR011333
DomainF_BAR

SRGAP2 SRGAP2C SRGAP2B

1.11e-03251543IPR031160
DomainF_BAR

SRGAP2 SRGAP2C SRGAP2B

1.11e-03251543PS51741
DomainChannel_four-helix_dom

KCNV2 SLC9C2 KCNG1 KCNS1

1.25e-03571544IPR027359
Domain-

KCNV2 SLC9C2 KCNG1 KCNS1

1.25e-035715441.20.120.350
DomainK_chnl_volt-dep_Kv9

KCNV2 KCNS1

1.38e-0371542IPR003971
DomainK_chnl_volt-dep_Kv

KCNV2 KCNG1 KCNS1

1.39e-03271543IPR003968
DomainPROTEIN_KINASE_ATP

TLK2 CAMK2A CAMK2D CAMK2G RPS6KB2 NEK9 MAP3K5 JAK2 PRKCE MAP3K15 NEK11

1.51e-0345915411PS00107
PathwayWP_DISRUPTION_OF_POSTSYNAPTIC_SIGNALING_BY_CNV

CAMK2A CAMK2D CAMK2G GRIN2C CYFIP1 NRXN1

2.79e-07331186M39875
PathwayREACTOME_NEGATIVE_REGULATION_OF_NMDA_RECEPTOR_MEDIATED_NEURONAL_TRANSMISSION

CAMK2A CAMK2D CAMK2G GRIN2C PPM1F

6.90e-07211185M27944
PathwayREACTOME_ASSEMBLY_AND_CELL_SURFACE_PRESENTATION_OF_NMDA_RECEPTORS

TUBB8 CAMK2A CAMK2D CAMK2G GRIN2C TUBB8B

1.65e-06441186M27934
PathwayREACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS

TUBB8 CAMK2A CAMK2D CAMK2G GRIN2C PPM1F TUBB8B

1.35e-05941187M2843
PathwayREACTOME_INTERFERON_GAMMA_SIGNALING

CAMK2A CAMK2D CAMK2G JAK2

1.64e-05191184MM15473
PathwayPID_IFNG_PATHWAY

CAMK2A CAMK2D CAMK2G CBL JAK2

1.96e-05401185M161
PathwayREACTOME_UNBLOCKING_OF_NMDA_RECEPTORS_GLUTAMATE_BINDING_AND_ACTIVATION

CAMK2A CAMK2D CAMK2G GRIN2C

2.50e-05211184M838
PathwayREACTOME_UNBLOCKING_OF_NMDA_RECEPTORS_GLUTAMATE_BINDING_AND_ACTIVATION

CAMK2A CAMK2D CAMK2G GRIN2C

3.04e-05221184MM15104
PathwayREACTOME_LONG_TERM_POTENTIATION

CAMK2A CAMK2D CAMK2G GRIN2C

3.65e-05231184M27949
PathwayWP_NOCGMPPKG_MEDIATED_NEUROPROTECTION

NPR1 CAMK2A CAMK2D CAMK2G GRIN2C

4.37e-05471185M39531
PathwayREACTOME_CAMK_IV_MEDIATED_PHOSPHORYLATION_OF_CREB

CAMK2A CAMK2D CAMK2G

6.57e-05101183M26910
PathwayKEGG_ERBB_SIGNALING_PATHWAY

CAMK2A CAMK2D CAMK2G RPS6KB2 CBL CBLB

8.80e-05871186M12467
PathwayREACTOME_INTERFERON_SIGNALING

TUBB8 CAMK2A CAMK2D CAMK2G OAS3 IFIT3 NUP205 JAK2 RSAD2 TUBB8B

9.76e-0527311810M983
PathwayWP_ERBB_SIGNALING

CAMK2A CAMK2D CAMK2G RPS6KB2 CBL CBLB

1.20e-04921186M39715
PathwayREACTOME_PHASE_0_RAPID_DEPOLARISATION

CAMK2A CAMK2D CAMK2G SCN3B

1.40e-04321184M27455
PathwayREACTOME_ION_CHANNEL_TRANSPORT

ATP6V1C1 CAMK2A CAMK2D CAMK2G SLC9C2 ANO8 TRPM8 UNC80

1.50e-041831188M997
PathwayREACTOME_RAF_ACTIVATION

CAMK2A CAMK2D CAMK2G JAK2

1.78e-04341184M27556
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_EGFR_TO_PLCG_CAMK_SIGNALING_PATHWAY

CAMK2A CAMK2D CAMK2G

1.95e-04141183M47386
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_PLCG_CAMK_SIGNALING_PATHWAY

CAMK2A CAMK2D CAMK2G

1.95e-04141183M47388
PathwayREACTOME_RAF_ACTIVATION

CAMK2A CAMK2D CAMK2G JAK2

2.00e-04351184MM15271
PathwayREACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS

CAMK2A CAMK2D CAMK2G GRIN2C

2.00e-04351184MM15109
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_CAMK_SIGNALING_PATHWAY

CAMK2A CAMK2D CAMK2G

2.42e-04151183M47385
PathwayKEGG_MEDICUS_REFERENCE_PDGF_PDGFR_PLCG_CAMK_SIGNALING_PATHWAY

CAMK2A CAMK2D CAMK2G

3.57e-04171183M47387
PathwayREACTOME_DAG_AND_IP3_SIGNALING

CAMK2A CAMK2D CAMK2G PRKCE

3.72e-04411184M512
PathwayWP_NONGENOMIC_ACTIONS_OF_125_DIHYDROXYVITAMIN_D3

CAMK2A CAMK2D CAMK2G RSAD2 PRKCE

4.08e-04751185M39568
PathwayKEGG_MEDICUS_REFERENCE_CA2_CAM_CAMK_SIGNALING_PATHWAY

CAMK2A CAMK2D CAMK2G

5.02e-04191183M47957
PathwayREACTOME_SIGNALING_BY_MODERATE_KINASE_ACTIVITY_BRAF_MUTANTS

CAMK2A CAMK2D CAMK2G JAK2

5.33e-04451184M27623
PathwayREACTOME_RAS_ACTIVATION_UPON_CA2_INFLUX_THROUGH_NMDA_RECEPTOR

CAMK2A CAMK2D CAMK2G

5.87e-04201183M17670
PathwayREACTOME_NEURONAL_SYSTEM

TUBB8 CAMK2A KCNV2 CAMK2D CAMK2G GRIN2C NRXN1 KCNG1 PPM1F KCNS1 TUBB8B

6.61e-0441111811M735
PathwayREACTOME_ION_CHANNEL_TRANSPORT

ATP6V1C1 CAMK2A CAMK2D CAMK2G ANO8 TRPM8 UNC80

6.91e-041761187MM15718
PathwayREACTOME_CARDIAC_CONDUCTION

NPR1 NPR2 CAMK2A CAMK2D CAMK2G SCN3B

7.77e-041301186M27454
PathwayREACTOME_HSF1_DEPENDENT_TRANSACTIVATION

CAMK2A CAMK2D CAMK2G

8.96e-04231183MM14953
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_ATP2B3_TO_ANGIOTENSIN_ALDOSTERONE_SIGNALING_PATHWAY

CAMK2A CAMK2D CAMK2G

8.96e-04231183M47512
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_CACNA1D_H_TO_ANGIOTENSIN_ALDOSTERONE_SIGNALING_PATHWAY

CAMK2A CAMK2D CAMK2G

1.02e-03241183M47509
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KCNJ5_TO_ANGIOTENSIN_ALDOSTERONE_SIGNALING_PATHWAY

CAMK2A CAMK2D CAMK2G

1.15e-03251183M47510
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_ATP1A1_TO_ANGIOTENSIN_ALDOSTERONE_SIGNALING_PATHWAY

CAMK2A CAMK2D CAMK2G

1.15e-03251183M47511
Pubmed

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

CAMK2A CAMK2D CAMK2G NEK9 KBTBD7 MAP3K5 FBXL18 KCNG1 FBXW5 RNF10 PRKCE MAP3K15 HERC6 NEK11

2.45e-093721611422939624
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

PDS5B RARS1 CAMK2D CAMK2G SMC1A UBR4 EXOC3 OAS3 HNRNPUL1 NSUN2 NEK9 NUP205 PLEK2 NCAPG CYFIP1 SLC25A12 FBXL18 PSME4 PLEKHG3 PPM1F XRN1 AKAP10 DDX24

7.71e-0813531612329467282
Pubmed

Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation.

SRGAP2 SRGAP2C SRGAP2B

9.74e-083161322559944
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

CAMK2A CAMK2D SRGAP2 PLEKHG2 HNRNPUL1 CBL NEK9 SYDE1 RADIL SH3PXD2B PLEKHG3 NECTIN2 SSX2IP XRN1 RNF10 NADK PRKCE DOP1B

1.15e-078611611836931259
Pubmed

Developmental rearrangements of cortical glutamate-NMDA receptor binding sites in late human gestation.

CAMK2A CAMK2D CAMK2G GRIN2C

2.13e-071216148665664
Pubmed

Activation of peripheral NMDA receptors contributes to human pain and rat afferent discharges evoked by injection of glutamate into the masseter muscle.

CAMK2A CAMK2D CAMK2G GRIN2C

2.13e-0712161412815021
Pubmed

Evolution of human-specific neural SRGAP2 genes by incomplete segmental duplication.

SRGAP2 SRGAP2C SRGAP2B

3.88e-074161322559943
Pubmed

Developmental expression of the CaM kinase II isoforms: ubiquitous gamma- and delta-CaM kinase II are the early isoforms and most abundant in the developing nervous system.

CAMK2A CAMK2D CAMK2G

3.88e-074161310381553
Pubmed

Cadmium activates CaMK-II and initiates CaMK-II-dependent apoptosis in mesangial cells.

CAMK2A CAMK2D CAMK2G

3.88e-074161317367784
Pubmed

[Molecular mechanisms of the intracellular localizations of Ca2+/calmodulin-dependent protein kinase II isoforms, and their physiological functions].

CAMK2A CAMK2D CAMK2G

3.88e-074161311889801
Pubmed

Delineating WWOX Protein Interactome by Tandem Affinity Purification-Mass Spectrometry: Identification of Top Interactors and Key Metabolic Pathways Involved.

RARS1 CAMK2D USP24 HNRNPUL1 NSUN2 TRAP1 CYFIP1 SLC25A12 PPM1F

8.53e-07217161930619736
Pubmed

Calmodulin kinase II attenuation of gene transcription by preventing cAMP response element-binding protein (CREB) dimerization and binding of the CREB-binding protein.

CAMK2A CAMK2D CAMK2G

9.67e-075161311013247
Pubmed

Alpha-kinase anchoring protein alphaKAP interacts with SERCA2A to spatially position Ca2+/calmodulin-dependent protein kinase II and modulate phospholamban phosphorylation.

CAMK2A CAMK2D CAMK2G

9.67e-075161319671701
Pubmed

Aberrant calcium/calmodulin-dependent protein kinase II (CaMKII) activity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brain.

CAMK2A CAMK2D CAMK2G

9.67e-075161321209221
Pubmed

Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II.

CAMK2A CAMK2D CAMK2G

9.67e-075161314722083
Pubmed

Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure.

CAMK2A CAMK2D CAMK2G

9.67e-075161318218981
Pubmed

Transition from reversible to persistent binding of CaMKII to postsynaptic sites and NR2B.

CAMK2A CAMK2D CAMK2G

9.67e-075161316436603
Pubmed

Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2.

CAMK2A CAMK2D CAMK2G

1.93e-066161316120608
Pubmed

Multiple kinases regulate mafA expression in the pancreatic beta cell line MIN6.

CAMK2A CAMK2D CAMK2G

1.93e-066161318948074
Pubmed

Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma.

CAMK2A CAMK2D CAMK2G

1.93e-066161311972023
Pubmed

Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1.

CBL CBLB JAK2

1.93e-066161310635327
Pubmed

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.

CAMK2A CAMK2D CAMK2G MAP3K5 CYFIP1 NRXN1 PRKCE PLCL1 CTNNA2

2.83e-06251161927507650
Pubmed

ERK1/2 inhibition promotes robust myotube growth via CaMKII activation resulting in myoblast-to-myotube fusion.

CAMK2A CAMK2D CAMK2G

3.36e-067161334932950
Pubmed

Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II.

CAMK2A CAMK2D CAMK2G

3.36e-06716139115241
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

TLK2 CAMK2A ACAD9 SMC1A EXOC3 SRGAP2 HNRNPUL1 NEK9 SYDE1 NME8 NUP205 TRAP1 CYFIP1 NRXN1 NECTIN2 NADK UQCC1 KATNIP DDX24 PCDH9

3.43e-0613211612027173435
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

TMEM94 UBR4 SRGAP2 ANO8 MAP3K5 RGMA JAK2 RADIL SH3PXD2B PSME4 KCNG1 PCNX4 USP40 NADK KCTD15 ATG9A ZNF426 RASD2

4.06e-0611051611835748872
Pubmed

Ca(2+)/CaM-dependent kinases: from activation to function.

CAMK2A CAMK2D CAMK2G

5.36e-068161311264466
Pubmed

Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation.

CAMK2A CAMK2D CAMK2G

5.36e-068161320668654
Pubmed

Calcineurin-independent regulation of plasma membrane Ca2+ ATPase-4 in the vascular smooth muscle cell cycle.

CAMK2A CAMK2D CAMK2G

8.01e-069161312660151
Pubmed

The presence and activation of two essential transcription factors (cAMP response element-binding protein and cAMP-dependent transcription factor ATF1) in the two-cell mouse embryo.

CAMK2A CAMK2D CAMK2G

1.14e-0510161319776387
Pubmed

CaMKII Signaling Stimulates Mef2c Activity In Vitro but Only Minimally Affects Murine Long Bone Development in vivo.

CAMK2A CAMK2D CAMK2G

1.14e-0510161328361052
Pubmed

Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice.

CAMK2D SRGAP2 CYFIP1 SLC25A12 NRXN1 CTNNA2

1.29e-05110161627889896
Pubmed

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.

CAMK2A CAMK2D CAMK2G SMC1A UBR4 HNRNPUL1 NEK9 CYFIP1 PSME4

1.32e-05304161932235678
Pubmed

PCP4 (PEP19) overexpression induces premature neuronal differentiation associated with Ca(2+) /calmodulin-dependent kinase II-δ activation in mouse models of Down syndrome.

CAMK2A CAMK2D CAMK2G

1.56e-0511161321491429
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SMC1A NEK9 ANO8 RADIL MYO15B LMBR1L PLEKHG3 SSX2IP FHDC1 UNC80 SCN3B

2.05e-054931611115368895
Pubmed

Expression of Ca2+/calmodulin-dependent protein kinase types II and IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl piperazine) in small cell lung carcinoma.

CAMK2A CAMK2D CAMK2G

2.08e-051216138615909
Pubmed

The pseudokinase domains of guanylyl cyclase-A and -B allosterically increase the affinity of their catalytic domains for substrate.

NPR1 NPR2

2.13e-052161230696704
Pubmed

Loss of Cbl and Cbl-b ubiquitin ligases abrogates hematopoietic stem cell quiescence and sensitizes leukemic disease to chemotherapy.

CBL CBLB

2.13e-052161225871390
Pubmed

A TNF- and c-Cbl-dependent FLIP(S)-degradation pathway and its function in Mycobacterium tuberculosis-induced macrophage apoptosis.

CBL MAP3K5

2.13e-052161219597496
Pubmed

Alterations of L-type calcium current and cardiac function in CaMKII{delta} knockout mice.

CAMK2A CAMK2D

2.13e-052161220538682
Pubmed

Chimeric natriuretic peptide ACNP stimulates both natriuretic peptide receptors, the NPRA and NPRB.

NPR1 NPR2

2.13e-052161223186809
Pubmed

SRGAP2 and Its Human-Specific Paralog Co-Regulate the Development of Excitatory and Inhibitory Synapses.

SRGAP2 SRGAP2C

2.13e-052161227373832
Pubmed

Adipocyte CAMK2 deficiency improves obesity-associated glucose intolerance.

CAMK2D CAMK2G

2.13e-052161234303021
Pubmed

ARALAR/AGC1 deficiency, a neurodevelopmental disorder with severe impairment of neuronal mitochondrial respiration, does not produce a primary increase in brain lactate.

SLC25A12 ACAN

2.13e-052161228429368
Pubmed

Cbl-b is a negative regulator of inflammatory cytokines produced by IgE-activated mast cells.

CBL CBLB

2.13e-052161217056522
Pubmed

Association of a new c-Cbl related protein with the very first stages of apoptosis induction.

CBL CBLB

2.13e-052161212102152
Pubmed

ATP potentiates competitive inhibition of guanylyl cyclase A and B by the staurosporine analog, Gö6976: reciprocal regulation of ATP and GTP binding.

NPR1 NPR2

2.13e-052161221828054
Pubmed

Cbl and Cbl-b control the germinal center reaction by facilitating naive B cell antigen processing.

CBL CBLB

2.13e-052161232584413
Pubmed

Porcine natriuretic peptide type B (pNPPB) maintains mouse oocyte meiotic arrest via natriuretic peptide receptor 2 (NPR2) in cumulus cells.

NPR1 NPR2

2.13e-052161224615855
Pubmed

Vasonatrin peptide stimulates both of the natriuretic peptide receptors, NPRA and NPRB.

NPR1 NPR2

2.13e-052161224699414
Pubmed

CaMKII is essential for the function of the enteric nervous system.

CAMK2A CAMK2G

2.13e-052161222952977
Pubmed

Guanylyl cyclase (GC)-A and GC-B activities in ventricles and cardiomyocytes from failed and non-failed human hearts: GC-A is inactive in the failed cardiomyocyte.

NPR1 NPR2

2.13e-052161222133375
Pubmed

Reactive oxygen species-activated Ca/calmodulin kinase IIδ is required for late I(Na) augmentation leading to cellular Na and Ca overload.

CAMK2A CAMK2D

2.13e-052161221252154
Pubmed

CaM kinase II regulates cardiac hemoglobin expression through histone phosphorylation upon sympathetic activation.

CAMK2D CAMK2G

2.13e-052161231619570
Pubmed

Rlbp1 promoter drives robust Müller glial GFP expression in transgenic mice.

PDE6B RLBP1

2.13e-052161219324864
Pubmed

Ischemic Injury-Induced CaMKIIδ and CaMKIIγ Confer Neuroprotection Through the NF-κB Signaling Pathway.

CAMK2D CAMK2G

2.13e-052161229992531
Pubmed

Ca2+/calmodulin-dependent protein kinase II-γ (CaMKIIγ) negatively regulates vascular smooth muscle cell proliferation and vascular remodeling.

CAMK2D CAMK2G

2.13e-052161226567004
Pubmed

The role of E3 ubiquitin ligase Cbl proteins in β-elemene reversing multi-drug resistance of human gastric adenocarcinoma cells.

CBL CBLB

2.13e-052161223665906
Pubmed

Guanylyl cyclases A and B are asymmetric dimers that are allosterically activated by ATP binding to the catalytic domain.

NPR1 NPR2

2.13e-052161222949736
Pubmed

Enhanced expression of natriuretic peptide receptor A and B in neutrophils of culprit lesions in patients with acute myocardial infarction.

NPR1 NPR2

2.13e-052161228765884
Pubmed

Cardiac CaM Kinase II genes δ and γ contribute to adverse remodeling but redundantly inhibit calcineurin-induced myocardial hypertrophy.

CAMK2D CAMK2G

2.13e-052161225124496
Pubmed

ATP-independent activation of natriuretic peptide receptors.

NPR1 NPR2

2.13e-052161215911610
Pubmed

c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation.

CBL CBLB

2.13e-052161212415267
Pubmed

Association analysis of single-nucleotide polymorphisms of USP24 and USP40 with Parkinson's disease in the Han Chinese population.

USP24 USP40

2.13e-052161222923019
Pubmed

Cbl-mediated K63-linked ubiquitination of JAK2 enhances JAK2 phosphorylation and signal transduction.

CBL JAK2

2.13e-052161228676638
Pubmed

[PI3K/Akt/Erk signaling pathway mediates neuroprotection of CaMKⅡγ and CaMKⅡδ against ischemic reperfusion injury in mice].

CAMK2D CAMK2G

2.13e-052161238597448
Pubmed

Adenine nucleotides decrease the apparent Km of endogenous natriuretic peptide receptors for GTP.

NPR1 NPR2

2.13e-052161217848634
Pubmed

Mitochondrial movement in Aralar/Slc25a12/AGC1 deficient cortical neurons.

SLC25A12 ACAN

2.13e-052161231472174
Pubmed

The human-specific paralogs SRGAP2B and SRGAP2C differentially modulate SRGAP2A-dependent synaptic development.

SRGAP2C SRGAP2B

2.13e-052161231822692
Pubmed

Basic fibroblast growth factor in retinal development: differential levels of bFGF expression and content in normal and retinal degeneration (rd) mutant mice.

PDE6B FGF2

2.13e-05216127750636
Pubmed

Cardiac hypertrophy is associated with altered thioredoxin and ASK-1 signaling in a mouse model of menopause.

MAP3K5 FSHR

2.13e-052161218676690
Pubmed

F-box/WD Repeat-Containing Protein 5 Mediates the Ubiquitination of Apoptosis Signal-Regulating Kinase 1 and Exacerbates Nonalcoholic Steatohepatitis in Mice.

MAP3K5 FBXW5

2.13e-052161230703849
Pubmed

Mass spectrometric identification of phosphorylation sites in guanylyl cyclase A and B.

NPR1 NPR2

2.13e-052161220977274
Pubmed

A novel CBL-Bflox/flox mouse model allows tissue-selective fully conditional CBL/CBL-B double-knockout: CD4-Cre mediated CBL/CBL-B deletion occurs in both T-cells and hematopoietic stem cells.

CBL CBLB

2.13e-052161227276677
Pubmed

Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia.

CBL CBLB

2.13e-052161217475912
Pubmed

Ventricular arrhythmias, increased cardiac calmodulin kinase II expression, and altered repolarization kinetics in ANP receptor deficient mice.

NPR1 CAMK2A

2.13e-052161215135664
Pubmed

Fasudil, a clinically safe ROCK inhibitor, decreases disease burden in a Cbl/Cbl-b deficiency-driven murine model of myeloproliferative disorders.

CBL CBLB

2.13e-052161226177294
Pubmed

Genetic evidence for ubiquitin-specific proteases USP24 and USP40 as candidate genes for late-onset Parkinson disease.

USP24 USP40

2.13e-052161216917932
Pubmed

Loss of Cbl-PI3K interaction in mice prevents significant bone loss following ovariectomy.

CBL CBLB

2.13e-052161224994594
Pubmed

Treadmill exercise enhances synaptic plasticity in the ischemic penumbra of MCAO mice by inducing the expression of Camk2a via CYFIP1 upregulation.

CAMK2A CYFIP1

2.13e-052161233497737
Pubmed

Effects of the lactase 13910 C/T and calcium-sensor receptor A986S G/T gene polymorphisms on the incidence and recurrence of colorectal cancer in Hungarian population.

CASR LCT

2.13e-052161218980667
Pubmed

The indolocarbazole, Gö6976, inhibits guanylyl cyclase-A and -B.

NPR1 NPR2

2.13e-052161221366551
Pubmed

CaM Kinase II mediates maladaptive post-infarct remodeling and pro-inflammatory chemoattractant signaling but not acute myocardial ischemia/reperfusion injury.

CAMK2D CAMK2G

2.13e-052161225193973
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

TLK2 PDS5B RARS1 CAMK2A CAMK2D SMC1A MRPL44 UBR4 SRGAP2 HNRNPUL1 NEK9 NUP205 RADIL NCAPG LOXHD1 SLC25A12 NADK DDX24

3.03e-0512841611817353931
Pubmed

Craniofacial abnormality with skeletal dysplasia in mice lacking chondroitin sulfate N-acetylgalactosaminyltransferase-1.

ACAN FGF2 CSGALNACT1

3.41e-0514161330459452
Pubmed

Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf.

CAMK2A CAMK2D CAMK2G

3.41e-0514161310373510
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

PDS5B LPCAT1 RARS1 ACAD9 CAMK2D UBR4 USP24 ARFGEF1 NSUN2 NUP205 NCAPG SLC25A12 LMBR1L PPM1F NECTIN2

3.49e-059421611531073040
Pubmed

The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1.

CAMK2A CAMK2D CAMK2G

4.25e-0515161314622581
Pubmed

Adjacent asparagines in the NR2-subunit of the NMDA receptor channel control the voltage-dependent block by extracellular Mg2+.

CAMK2A CAMK2D CAMK2G

4.25e-051516139481670
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

TLK2 CAMK2A CAMK2D CAMK2G UBR4 SRGAP2 NEK9 MAP3K5 SH3PXD2B CYFIP1 NRXN1 CDK5RAP2 PRKCE PLCL1 CTNNA2

4.48e-059631611528671696
Pubmed

ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease.

ATP6V1C1 CAMK2A CAMK2D CAMK2G MAP3K5 SLC25A12 CTNNA2

4.60e-05202161733601422
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

CAMK2A CAMK2D CAMK2G SRGAP2 CYFIP1 PRKCE PLCL1 CTNNA2

5.31e-05281161828706196
Pubmed

The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.

RARS1 UBR4 USP24 CYFIP1 SLC25A12 PSME4 XRN1

6.25e-05212161733853758
Pubmed

Regulation of immune responses by E3 ubiquitin-protein ligases.

CBL CBLB

6.37e-053161211826757
Pubmed

Cbl-b regulates the CD28 dependence of T-cell activation.

CBL CBLB

6.37e-053161210646609
Pubmed

Cbl-b and c-Cbl negatively regulate osteoblast differentiation by enhancing ubiquitination and degradation of Osterix.

CBL CBLB

6.37e-053161225744063
Pubmed

The oxidation-resistant CaMKII-MM281/282VV mutation does not prevent arrhythmias in CPVT1.

CAMK2A CAMK2D

6.37e-053161234558218
Pubmed

Crucial role for Ca2(+)/calmodulin-dependent protein kinase-II in regulating diastolic stress of normal and failing hearts via titin phosphorylation.

CAMK2D CAMK2G

6.37e-053161223283722
Pubmed

CaMKII-δ9 promotes cardiomyopathy through disrupting UBE2T-dependent DNA repair.

CAMK2A CAMK2G

6.37e-053161231481791
Pubmed

A sensitive method for determining the phosphorylation status of natriuretic peptide receptors: cGK-Ialpha does not regulate NPR-A.

NPR1 NPR2

6.37e-053161216430226
GeneFamilyRho GTPase activating proteins|F-BAR domain containing

SRGAP2 SRGAP2C SRGAP2B

2.68e-042310031288
GeneFamilyGuanylate cyclase receptors

NPR1 NPR2

6.25e-0471002343
GeneFamilyPotassium voltage-gated channels

KCNV2 KCNG1 KCNS1

1.40e-03401003274
CoexpressionGSE42021_TREG_PLN_VS_CD24LO_TREG_THYMUS_DN

PGS1 OAS3 IFIT3 TRANK1 TLL1 NECTIN2 HERC6 DDX24 ZNF426

3.43e-061971599M9580
CoexpressionGSE26030_TH1_VS_TH17_DAY5_POST_POLARIZATION_UP

UBR4 OAS3 NSUN2 IFIT3 SETDB2 RSAD2 SLC25A12 HERC6 DOP1B

3.88e-062001599M8564
CoexpressionERWIN_COHEN_BLOOD_TC_83_AGE_23_48YO_VACCINATED_VS_CONTROL_2DY_UP

OAS3 SRGAP2 IFIT3 SRGAP2C RSAD2 SRGAP2B HERC6

8.40e-061191597M41139
CoexpressionGSE3982_DC_VS_NEUTROPHIL_DN

TLK2 PADI4 CASR TRANK1 TECPR2 PLEKHG3 NADK CSGALNACT1

2.84e-051971598M5462
CoexpressionGSE11961_FOLLICULAR_BCELL_VS_MEMORY_BCELL_DAY7_UP

UBR4 CYP27A1 OAS3 IFIT3 JAK2 SETDB2 PRKCE HERC6

3.17e-052001598M9338
CoexpressionGSE19888_ADENOSINE_A3R_INH_VS_TCELL_MEMBRANES_ACT_MAST_CELL_UP

TLK2 C2orf68 IFIT3 JAK2 SETDB2 RSAD2 AKAP10 HERC6

3.17e-052001598M7324
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated|COVID-19_Mild / Disease, condition lineage and cell class

LPCAT1 USP24 OAS3 IFIT3 RSAD2 TRANK1 PLEKHG3 HERC6 IL2RB

5.04e-0820016192281debd86e5d92e8fe0397aec9ef670800f7471
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Granulocytic-Neutrophil-Neu_c5-GSTP1(high)OASL(low)|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

OAS3 IFIT3 RSAD2 TRANK1 XRN1 NADK CCR3 HERC6

1.46e-071631618d005115aa1e1458b51de7eb719794617a4168608
ToppCellCOVID-19_Moderate-NK_activated|World / disease group, cell group and cell class

LPCAT1 OAS3 IFIT3 RSAD2 TRANK1 PLEKHG3 HERC6 IL2RB

4.02e-071861618ff8f32f69516bf785224fa12f8139a95359b0279
ToppCellBAL-Mild|BAL / Compartment, Disease Groups and Clusters

OAS3 SRGAP2 IFIT3 SRGAP2C RSAD2 TRANK1 XRN1 HERC6

5.11e-0719216181a6cbf014d3f7a3fb6f53adab078c4742e7137de
ToppCelldroplet-Lung-nan-3m-Myeloid-Classical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PADI4 CYP27A1 OAS3 IFIT3 MIA2 ASAH1 NADK

1.05e-061461617ed932d43e9efd064ee4b49ddef529f3d041be765
ToppCelldroplet-Lung-nan-3m-Myeloid-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PADI4 CYP27A1 OAS3 IFIT3 MIA2 ASAH1 NADK

1.05e-0614616170d74962779055c774312d59fc3b1365163741c3a
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BTNL8 CAMK2A CCDC168 LCT CBLB CLIC5 UNC80

1.86e-061591617fd7db2f7328cfefdc3ada2af91006d5a91d137e1
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BTNL8 CAMK2A CCDC168 LCT CBLB CLIC5 UNC80

1.86e-061591617aaf449c768d6fbb0a1bb47746ff3bdb7f9eb8914
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BTNL8 CAMK2A CCDC168 LCT CBLB CLIC5 UNC80

1.86e-0615916178bbdef1e927f3130b578d7d7c5ff38bbe06fab63
ToppCellBAL-Severe-Myeloid-Neutrophil|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

LPCAT1 PGS1 BTNL8 IFIT3 RSAD2 TECPR2 NADK

3.26e-0617316175b76d9cc56bbb29017e64a2d0a3c76c0be003d96
ToppCellBAL-Severe-Myeloid-Neutrophil-Neutrophil-Neu_3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LPCAT1 PGS1 BTNL8 IFIT3 RSAD2 TECPR2 NADK

3.26e-061731617bf685025961e79b379f2c35464b6c8ce3e31ace0
ToppCellBAL-Severe-Myeloid-Neutrophil|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LPCAT1 PGS1 BTNL8 IFIT3 RSAD2 TECPR2 NADK

3.26e-061731617a6e73a40b0d5356564a594053e772f9d061a5919
ToppCellBAL-Severe-Myeloid-Neutrophil-Neutrophil|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LPCAT1 PGS1 BTNL8 IFIT3 RSAD2 TECPR2 NADK

3.26e-061731617a8b5370f4c893a20c58e97659f3ac168699693f8
ToppCellBAL-Severe-Myeloid-Neutrophil-Neutrophil-Neu_3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

LPCAT1 PGS1 BTNL8 IFIT3 RSAD2 TECPR2 NADK

3.26e-0617316171edef5aeab626cbf2c09468e77b02cfa2d21ba03
ToppCellBAL-Severe-Myeloid-Neutrophil-Neutrophil|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

LPCAT1 PGS1 BTNL8 IFIT3 RSAD2 TECPR2 NADK

3.26e-061731617c37dba3804df7c3151e18e6ae4e0b6e7a92bae97
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Granulocytic-Neutrophil-Neu_c4-RSAD2|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PGS1 OAS3 IFIT3 RSAD2 PAEP XRN1 HERC6

3.52e-06175161797616bb5c127284aa9e67bc336dfcf29e137164b
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LPCAT1 OAS3 IFIT3 RSAD2 TRANK1 PCNX4 IL2RB

3.79e-061771617d3e6c768b88b7906f3c7fdd00ba20842212c14b1
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LPCAT1 OAS3 IFIT3 RSAD2 TRANK1 PCNX4 IL2RB

3.79e-061771617f8f101c772c043636bedd6b2ec81409b1d2599bf
ToppCellSevere_COVID-19-Myeloid-Neutrophil|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）

LPCAT1 PGS1 BTNL8 IFIT3 RSAD2 TECPR2 NADK

3.79e-061771617a6fae376f1beb1df423484d9b1bd1d954ca117af
ToppCellCOVID-19_Mild-Lymphoid_T/NK-NK_activated|COVID-19_Mild / Disease group, lineage and cell class

LPCAT1 OAS3 IFIT3 RSAD2 TRANK1 PCNX4 IL2RB

3.79e-0617716176978a22fef40c8b455342373abe7593f5ede0fa4
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

LPCAT1 OAS3 IFIT3 RSAD2 TRANK1 PCNX4 IL2RB

3.79e-061771617936ab2b180a052387124f68d0c7f41c0b164e748
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

LPCAT1 OAS3 IFIT3 RSAD2 TRANK1 PCNX4 IL2RB

3.79e-061771617d5aeda113afaa2425874394610344570c9078478
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMC1A IFIT3 RSAD2 CLIC5 XRN1 UBXN2A HERC6

3.94e-06178161701dafd19de04eff459253eaa9a35debf8f3deedf
ToppCellSevere-Myeloid-Neutrophil|Severe / Condition, Lineage, Cell class and cell subclass

LPCAT1 PGS1 BTNL8 IFIT3 RSAD2 TECPR2 NADK

3.94e-061781617454313efe59d71e7327b9758efabf2d893e4a8fd
ToppCellSevere-Myeloid-Neutrophil-|Severe / Condition, Lineage, Cell class and cell subclass

LPCAT1 PGS1 BTNL8 IFIT3 RSAD2 TECPR2 NADK

3.94e-0617816178618ae891d62bf70fe860ff7bb2d31868961aa13
ToppCellCOVID-19_Severe-Neutrophil-|COVID-19_Severe / Disease condition and Cell class

PGS1 BTNL8 IFIT3 RSAD2 FBXL18 TECPR2 CDK5RAP2

4.39e-0618116175e5101195d5ff8c8ea7ddcf0bc4f4e03e64c01e0
ToppCellCOVID-19_Severe-Neutrophil|COVID-19_Severe / Disease condition and Cell class

PGS1 BTNL8 IFIT3 RSAD2 FBXL18 TECPR2 CDK5RAP2

4.39e-061811617aa5e5fb0308b5e2ef918548c85529c9a433c57f5
ToppCellB_cells-ISG-high_B_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

MRPL44 OAS3 CPNE5 IFIT3 RSAD2 TRANK1 XRN1

4.72e-061831617dc2b00e920efa1dcc2a6265cd1024e3249c9974f
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

OAS3 IFIT3 CLIC5 PRKCE AMMECR1 DISP1 PARP15

5.44e-061871617f3397dbc23b6c2f24e2c1ba887d8f9aef3ee01a1
ToppCell390C-Lymphocytic-CD4_T-cell-Treg_cell_1|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

KBTBD6 ACAD9 NUP205 TRAP1 MYO15B FBXL18 FAM199X

5.64e-0618816172c4e791df69a9df29922f9117e5cac7787c129ce
ToppCellCOPD-Myeloid-ncMonocyte|COPD / Disease state, Lineage and Cell class

PADI4 PGS1 SRGAP2 ASAH1 PPM1F PRKCE SRGAP2B

6.69e-061931617936ca95995599356b794fba32bfd82d8de339365
ToppCellmoderate-Myeloid-Monocyte-derived_Macrophage|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

OAS3 SRGAP2 IFIT3 RSAD2 XRN1 FGF2 HERC6

6.69e-06193161722455801194bd8c73c5c397f5eac4f723429c383
ToppCellB_cells-ISG-high_B_cells|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis

MRPL44 OAS3 IFIT3 RSAD2 TRANK1 XRN1 HERC6

7.16e-061951617b64d9e1a8834401b4dc501566546647754ae21fc
ToppCellVE-CD4-antiviral_CD4|VE / Condition, Cell_class and T cell subcluster

OAS3 IFIT3 LINS1 RSAD2 TRANK1 XRN1 HERC6

8.17e-061991617056a0538ca5e825ae6195b4c76c208708a014533
ToppCellCOVID-19-COVID-19_Mild-Myeloid-Neutrophil|COVID-19_Mild / Disease, condition lineage and cell class

PADI4 BTNL8 IFIT3 RSAD2 FBXL18 TECPR2 CCR3

8.17e-0619916179f6b6731186ef399f952a75879eba66fd8ed3494
ToppCellCOVID-19_Moderate|World / disease group, cell group and cell class

OAS3 IFIT3 RSAD2 TRANK1 XRN1 HERC6 DDX24

8.17e-061991617952fac67588ad5676f5939e3c7f8bac803c27064
ToppCellmild-CD8+_Tem|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

CBLB IFIT3 RSAD2 TRANK1 XRN1 DDX24 PARP15

8.45e-062001617d8aec4904c9420b8f9d7508658ba1e36c66cdfcc
ToppCellHematolymphoid-Microglia-TYROBP----L1-3|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SRGAP2 CBL MAP3K5 SRGAP2C CYFIP1 SRGAP2B CSGALNACT1

8.45e-062001617a20dce14f94777687aad57d6fbe3258ad376f63f
ToppCellHematolymphoid-Microglia-TYROBP--|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SRGAP2 CBL MAP3K5 SRGAP2C CYFIP1 SRGAP2B CSGALNACT1

8.45e-062001617dc344b3ec51d506952e38f0b3a7795d65f9dd4eb
ToppCellHematolymphoid-Microglia-TYROBP-|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SRGAP2 CBL MAP3K5 SRGAP2C CYFIP1 SRGAP2B CSGALNACT1

8.45e-0620016173bba5219453322198e8fdb0921d5f8c403598751
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TLK2 OAS3 IFIT3 JAK2 RSAD2 XRN1 DDX24

8.45e-06200161712f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellHematolymphoid-Microglia|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SRGAP2 CBL MAP3K5 SRGAP2C CYFIP1 SRGAP2B CSGALNACT1

8.45e-06200161721bcca3b670fe9bac034aef2275d3de4a9a73e2b
ToppCellHematolymphoid-Microglia-TYROBP---|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SRGAP2 CBL MAP3K5 SRGAP2C CYFIP1 SRGAP2B CSGALNACT1

8.45e-062001617a8646d0fca99f10827c2d2a12e584660ef7155f1
ToppCellHematolymphoid-Microglia-TYROBP|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SRGAP2 CBL MAP3K5 SRGAP2C CYFIP1 SRGAP2B CSGALNACT1

8.45e-06200161733036d21c1c82109284473a515c4f890b33fdd5c
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SRGAP2 SYDE1 PEBP4 SRGAP2C CLIC5 TMEM150C

2.15e-051551616e7f49e2fdaf184fa6b4e685518004e7deff1316d
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SRGAP2 SYDE1 PEBP4 SRGAP2C CLIC5 TMEM150C

2.15e-0515516165a872ca70ae8c30b57f45a6772d7bf565e0c2663
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNV2 TLL1 FSHR TRPM8 CTNNA2 UNC80

2.57e-051601616c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNV2 TLL1 FSHR TRPM8 CTNNA2 UNC80

2.57e-05160161625c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellPND07-28-samps-Epithelial-Epithelial-non_alveolar-Club_cell|PND07-28-samps / Age Group, Lineage, Cell class and subclass

PGS1 MRPL44 TECPR2 SSX2IP FHDC1 TTLL10

2.76e-051621616aed15eef32419b8a4e2afdb9776c2bf2802e96f1
ToppCell367C-Myeloid-Monocyte-CD16+_Monocyte|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

ZNF597 TLK2 EXOC3 ANO8 SSX2IP PARP15

2.96e-0516416161aff83fc73b4e41e6f0d4b04dbca153bcc7a3518
ToppCelldroplet-Lung-30m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CYP27A1 OAS3 IFIT3 MIA2 ASAH1 NADK

2.96e-051641616f88871d3b9307112eb7ced4c629f5704326ecae8
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NLRP12 PADI4 CUBN EYS NRXN1 CTNNA2

3.27e-0516716163edb0570e583bb527165bcd8a4c25a042054043b
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil-Neu_c5-GSTP1(high)OASL(low)|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

IFIT3 MAP3K5 RSAD2 TRANK1 XRN1 NADK

3.62e-05170161607b561cd9c528bc8444c9385e1de621eee7b697e
ToppCell367C-Myeloid-Monocyte-CD16+_Monocyte|Monocyte / Donor, Lineage, Cell class and subclass (all cells)

ZNF597 TLK2 TBC1D8B ANO8 SSX2IP PARP15

3.86e-051721616fb8ab2576b5c38db63573a3bf46b8d9d634c4999
ToppCellRSV-Healthy-1|Healthy / Virus stimulation, Condition and Cluster

OAS3 CPNE5 IFIT3 RSAD2 MYO15B HERC6

4.25e-051751616ff3a27f512a3a710ebc863b7b75cce8167d5440b
ToppCellRSV-Healthy-1|RSV / Virus stimulation, Condition and Cluster

OAS3 CPNE5 IFIT3 RSAD2 MYO15B HERC6

4.25e-051751616ca52b99b03535a5b3a2751d6981708dc5b255b91
ToppCellPBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_activate-7|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CAMK2D CPNE5 IFIT3 ZIK1 USP40 PCDH9

4.39e-051761616dde46f06f6fc3f7ba83be91a0ee6231790955e3e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SRGAP2 CBLB SRGAP2C CLIC5 TMEM150C SRGAP2B

4.53e-0517716164d2cdb57b427a42085c5f9affa0967b15e84dec3
ToppCellwk_15-18-Epithelial-PNS-COL20A1+_Schwann|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

COL28A1 RLBP1 NRXN1 KCNS1 CTNNA2 UNC80

4.53e-051771616b8cc6a7abf83a9844a5293b6cc4b19135b51fd53
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SRGAP2 CBLB SRGAP2C CLIC5 TMEM150C SRGAP2B

4.67e-051781616edc7143dc9959d36057cb9471681a23afcbc8cce
ToppCellT_cells-ISG-high_CD4+_T_cells|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis

OAS3 IFIT3 RSAD2 TRANK1 XRN1 HERC6

4.82e-051791616af35ef8a7768cee0c2af0590e5bec35cee6a4714
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-5|TCGA-Colorectal / Sample_Type by Project: Shred V9

CAMK2D MFSD9 MAP3K5 PLEK2 MIA2 DOP1B

5.13e-0518116168fcc9e77fee7c248df26b6c59b10e672242e2084
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

OAS3 IFIT3 LINS1 RSAD2 TRANK1 HERC6

5.29e-0518216161aea96ee211f7b9caef7fd385233f51be6021a73
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Degenerative_Podocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NPR1 PEBP4 SRGAP2C CLIC5 TMEM150C SRGAP2B

5.29e-051821616cde8fa4f42d25545abaa9ee885b4b1e24a5a8e08
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

OAS3 IFIT3 LINS1 RSAD2 TRANK1 HERC6

5.29e-051821616b427e43ee523a3ea9eca3207f3d82042f10f022a
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

OAS3 IFIT3 LINS1 RSAD2 TRANK1 HERC6

5.29e-051821616c0f63cfc67d61c0877b7acb2946dfb35aae8a8f5
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

OAS3 IFIT3 LINS1 RSAD2 TRANK1 HERC6

5.29e-0518216164cb182ef39be2044a6ad7266f332d4177591e550
ToppCellCOVID-19_Mild-Lymphoid_T/NK-CD4+_T_activated|COVID-19_Mild / Disease group, lineage and cell class

OAS3 IFIT3 LINS1 RSAD2 TRANK1 HERC6

5.45e-0518316167717fce227b4e02ed41baad8ae7dd2e22bd7c13e
ToppCellCOVID-19-kidney-Podocyte|kidney / Disease (COVID-19 only), tissue and cell type

SRGAP2 CBLB SRGAP2C CLIC5 TMEM150C SRGAP2B

5.45e-051831616fb5e2a31b560126e1c04a386c24c365901c60ad7
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SRGAP2 CBLB SRGAP2C CLIC5 TMEM150C SRGAP2B

5.45e-0518316163c516fe5083f02bad1f464ed284010b4131a833c
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SRGAP2 CBLB SRGAP2C CLIC5 TMEM150C SRGAP2B

5.45e-051831616612d93df03252d4d2ccdce5a9bc162cfd9172a1a
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NPR1 SRGAP2 CBLB SRGAP2C CLIC5 SRGAP2B

5.45e-051831616848fc6dd129150897ee339343e83c645b6e779eb
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SRGAP2 CBLB SRGAP2C CLIC5 TMEM150C SRGAP2B

5.45e-051831616eb559ae3ae252d9365c24ef557dd49b78ed6d898
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SRGAP2 CBLB SRGAP2C CLIC5 TMEM150C SRGAP2B

5.45e-0518316169c2689d76fc6d30f5ab093428aa669d0a98953cf
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SRGAP2 CBLB SRGAP2C CLIC5 TMEM150C SRGAP2B

5.45e-0518316167c4b775f351794a3de06bd503eecbc8ae8577c44
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SRGAP2 CBLB SRGAP2C CLIC5 TMEM150C SRGAP2B

5.62e-0518416167294b379ce4cb8fa75e432559082f93cd106aaf5
ToppCellControl-CD8+_T_activated|Control / Disease group and Cell class

ACAD9 OAS3 IFIT3 RSAD2 LMBR1L PRKCE

5.62e-051841616b86cc48b744b3206880ec1373fe6068e14bf9680
ToppCellIPF-Epithelial-ATII|IPF / Disease state, Lineage and Cell class

LPCAT1 PEBP4 LGI3 SCTR FHDC1 PCDH9

5.79e-051851616563b4e6d92bb5d77a3829556116a8e99aebac615
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

OAS3 IFIT3 SRGAP2C RSAD2 TRANK1 XRN1

5.79e-051851616f30fb9d75cdb757b206312992aaf7485bc900f96
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SRGAP2 CBLB SRGAP2C CLIC5 TMEM150C SRGAP2B

5.79e-0518516169197f074e769d54031ec41abfc65fcc0c6552c7e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SRGAP2 CBLB SRGAP2C CLIC5 TMEM150C SRGAP2B

5.79e-051851616ce7d62394b09c26ca65b8cdb280afec5e25bbb62
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NPR1 SRGAP2 CBLB SRGAP2C CLIC5 SRGAP2B

5.79e-051851616b848b63aff4d9dbb9e66a85876d4c7c6dacd0579
ToppCellLA-04._Ventricular_Cardiomyocyte_I|World / Chamber and Cluster_Paper

LCT IFIT3 FHDC1 IL2RB PARP15

5.91e-051141615ca69dddbdc02fa5718c56362649cd4b9b54f94ce
ToppCell10x5'-Lung-Lymphocytic_Invariant-Inducer-like-ILC3|Lung / Manually curated celltypes from each tissue

PADI4 ZBTB6 SCRN1 SERAC1 TTLL10 PCDH9

6.14e-0518716160e7aa481effdd8c2fbdf8b65852821dec2d92cde
ToppCellAdult-Epithelial-club_cell-D231|Adult / Lineage, Cell type, age group and donor

CASR CUBN TLL1 PAEP TMEM150C PLCL1

6.14e-051871616ee59d7d3de5879738ff0b9c3ea5e4847fb48cb86
ToppCellcritical-Myeloid-Monocyte-derived_Macrophage|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

OAS3 IFIT3 RSAD2 LGI3 XRN1 HERC6

6.14e-05187161672e4aec49ea0c5fe6cee2a1a46369dbc90cd3fad
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CAMK2A SRGAP2 SRGAP2C CLIC5 TMEM150C SRGAP2B

6.14e-05187161624c2a3962da364e46e98abeab5f8234376fa26bb
ToppCellIPF-Epithelial-ATII|Epithelial / Disease state, Lineage and Cell class

LPCAT1 NPR1 PEBP4 LGI3 SCTR PCDH9

6.33e-0518816165f5fad2773e421760e67dbace23fd1f847a2e1e0
ToppCell(6)_ILC|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

CASR NECTIN2 TRPM8 TTLL10 PCDH9 SLC44A3

6.33e-051881616de7cb273899d0e0748c85f45c6b5e7f0642ab057
ToppCellT_cells-ISG-high_CD4+_T_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

OAS3 IFIT3 RSAD2 TRANK1 XRN1 HERC6

6.33e-0518816166f8946d4710f6e32c937213f99b790b098b8819c
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Degenerative_Podocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CAMK2A SRGAP2 SRGAP2C CLIC5 TMEM150C SRGAP2B

6.33e-0518816169db778c1d9e622a68337212296e3a1ed8f771fa5
ToppCell390C-Lymphocytic-CD4_T-cell-Treg_cell_1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

KBTBD6 ACAD9 NUP205 TRAP1 MYO15B FBXL18

6.33e-051881616b1ec7c45aedcc3d22cac898c6a3679e7f8b44c77
ToppCell(6)_ILC|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

CASR NECTIN2 TRPM8 TTLL10 PCDH9 SLC44A3

6.33e-051881616f4734d5b703678670ece204a0519cf015e180a6e
ToppCellCOVID-19_Moderate-NK_activated|COVID-19_Moderate / disease group, cell group and cell class

IFIT3 PEBP4 RSAD2 PLEKHG3 HERC6 IL2RB

6.52e-0518916168f9f1e71857bed6d59c4b087b6a6970f30fd86be
ToppCellRV-15._Ventricular_Cardiomyocyte_III|World / Chamber and Cluster_Paper

CAMK2D CPNE5 JAK2 CLIC5 PSME4 PLCL1

6.52e-0518916160a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCellCOPD-Myeloid-ncMonocyte|World / Disease state, Lineage and Cell class

PADI4 SRGAP2 SRGAP2C PPM1F PRKCE SRGAP2B

6.71e-051901616aece860b5609ad5a8fc920d685f0d0ec71bf9018
ToppCellRV-15._Ventricular_Cardiomyocyte_III|RV / Chamber and Cluster_Paper

CAMK2D CPNE5 JAK2 CLIC5 PSME4 PLCL1

6.71e-05190161693c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCellLPS_only-Endothelial-Endothelial-Alv_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IFIT3 CLIC5 PRKCE AMMECR1 CSGALNACT1 DISP1

6.71e-051901616474cbbab8f3b0a6881fa6c92edb78e43999f9ab0
ToppCellIPF-Myeloid-ncMonocyte|World / Disease state, Lineage and Cell class

PADI4 SRGAP2 SRGAP2C ASAH1 PPM1F SRGAP2B

6.71e-051901616f9c2a13c7f6460e3b348581be855b7281c8f70b5
ToppCellCalu_3-infected-SARSCoV2|infected / Cell line, Condition and Strain

OAS3 IFIT3 RSAD2 TRANK1 XRN1 HERC6

6.91e-0519116162da876d26f37a00dbdf1ee79d724306e8b20f304
DiseaseE3 ubiquitin-protein ligase CBL measurement

NLRP12 CBL

2.67e-0521532EFO_0801552
Diseasealcohol drinking

OAS3 TRPM8 PLCL1 CTNNA2 NEK11

6.55e-05811535EFO_0004329
DiseaseNAD kinase measurement

NLRP12 NADK

7.99e-0531532EFO_0801821
DiseaseIntellectual Disability

TLK2 RARS1 TMEM94 CAMK2A NSUN2 LINS1 NRXN1 ASAH1 SERAC1 CTNNA2

1.20e-0444715310C3714756
DiseaseInfluenza

OAS3 IFIT3 RSAD2 HERC6

1.55e-04521534C0021400
Diseaseinosine-5'-monophosphate dehydrogenase 1 measurement

NLRP12 TECPR2

1.59e-0441532EFO_0008158
Diseasetransmembrane protein 230 measurement

NLRP12 SH3PXD2B

1.59e-0441532EFO_0802156
Diseasemyeloproliferative neoplasm (implicated_via_orthology)

CBL JAK2

1.59e-0441532DOID:2226 (implicated_via_orthology)
DiseaseETS domain-containing protein Elk-3 measurement

NLRP12 SV2A

3.95e-0461532EFO_0801588
Diseaseamphetamine abuse (implicated_via_orthology)

MAP3K5 MAP3K15

3.95e-0461532DOID:670 (implicated_via_orthology)
Diseaseachondroplasia (implicated_via_orthology)

NPR2 ACAN

3.95e-0461532DOID:4480 (implicated_via_orthology)
Diseaseacid ceramidase measurement

NLRP12 SV2A

3.95e-0461532EFO_0801339
Diseaselon protease homolog, mitochondrial measurement

NLRP12 SV2A

3.95e-0461532EFO_0801771
Diseasestathmin-2 measurement

NLRP12 ATG9A

3.95e-0461532EFO_0802087
Diseasefructose-1,6-bisphosphatase 1 measurement

NLRP12 PCNX4

3.95e-0461532EFO_0801606
Diseasemyeloid neoplasm (is_implicated_in)

CBL JAK2

5.51e-0471532DOID:0070004 (is_implicated_in)
Diseaseautism spectrum disorder (is_marker_for)

CYFIP1 SLC25A12

5.51e-0471532DOID:0060041 (is_marker_for)
Diseaseheart conduction disease (implicated_via_orthology)

CAMK2A CAMK2D CAMK2G

6.07e-04321533DOID:10273 (implicated_via_orthology)
Diseaseinterferon-induced protein with tetratricopeptide repeats 3 measurement

NLRP12 IFIT3

7.33e-0481532EFO_0801710
DiseaseThrombocytosis, Autosomal Dominant

JAK2 FGF2

9.39e-0491532C3489628
DiseaseAutism Spectrum Disorders

NSUN2 NRXN1 PCDH9 UNC80

1.02e-03851534C1510586
Diseaseptosis (implicated_via_orthology)

TUBB8 TUBB8B

1.17e-03101532DOID:0060260 (implicated_via_orthology)
Diseasetubulinopathy (implicated_via_orthology)

TUBB8 TUBB8B

1.17e-03101532DOID:0112227 (implicated_via_orthology)
Diseasefacial paralysis (implicated_via_orthology)

TUBB8 TUBB8B

1.17e-03101532DOID:13934 (implicated_via_orthology)
Diseasecomplex cortical dysplasia with other brain malformations 7 (implicated_via_orthology)

TUBB8 TUBB8B

1.17e-03101532DOID:0090132 (implicated_via_orthology)
Diseaseprogression free survival, response to carboplatin, methylcobalamin deficiency type cblE, ovarian serous carcinoma

EYS CTNNA2 CSGALNACT1

1.35e-03421533EFO_0004920, EFO_1001516, GO_0097328, MONDO_0009354
Diseasecerebellar ataxia, mental retardation and dysequlibrium syndrome (implicated_via_orthology)

TUBB8 TUBB8B

1.70e-03121532DOID:0050997 (implicated_via_orthology)
DiseaseHematologic Neoplasms

CBL JAK2

1.70e-03121532C0376545
DiseaseThrombocythemia, Essential

JAK2 FGF2

1.70e-03121532C0040028
Diseaseoropharynx cancer

CBLB JAK2 CSGALNACT1

1.76e-03461533EFO_1001931
DiseaseMyocardial Ischemia

CAMK2D JAK2 RSAD2 FGF2 PRKCE

2.29e-031761535C0151744
Diseaseinterleukin 12 measurement

KCNV2 CAPN11 SPATS1

2.65e-03531533EFO_0004753
Diseasecopine-1 measurement

NLRP12 UQCC1

3.45e-03171532EFO_0008102
Diseaseautosomal dominant intellectual developmental disorder (is_implicated_in)

TLK2 CAMK2G

3.45e-03171532DOID:0060307 (is_implicated_in)
Diseasesleep duration, high density lipoprotein cholesterol measurement

PGS1 TMEM94 RGMA NECTIN2

3.69e-031211534EFO_0004612, EFO_0005271
Diseaseresponse to antipsychotic drug

EYS CDK5RAP2 CTNNA2

3.77e-03601533GO_0097332
Diseaseabdominal fat cell number

BTNL8 COL28A1 SLC9C2 PRKCE CTNNA2

3.80e-031981535EFO_0021534
Diseaselevel of Sterol ester (27:1/20:3) in blood serum

USP24 NRXN1

4.31e-03191532OBA_2045199
Diseaseatherosclerosis (biomarker_via_orthology)

CASR JAK2

4.77e-03201532DOID:1936 (biomarker_via_orthology)
Diseasemyocardial infarction (implicated_via_orthology)

MAP3K5 JAK2 CCR3

4.93e-03661533DOID:5844 (implicated_via_orthology)
DiseaseDisorder of eye

PDE6B KCNV2 CYP27A1 RLBP1 EYS

5.06e-032121535C0015397
DiseaseGlobal developmental delay

RARS1 TMEM94 SLC25A12 CTNNA2

5.16e-031331534C0557874

Protein segments in the cluster

PeptideGeneStartEntry
DAAYDCFIFSDVDLV

B4GALT2

206

O60909
NVLLFFCDVDIYFTS

CSGALNACT1

351

Q8TDX6
FCDVDIYFTSEFLNT

CSGALNACT1

356

Q8TDX6
LDYECGTISFFNIND

BTNL8

411

Q6UX41
ADILFCESALFYFSE

AKAP10

381

O43572
FCTEDNIEQSISYLD

SSX2IP

56

Q9Y2D8
AICDVFTQYLEVLSD

ARFGEF1

1461

Q9Y6D6
CIDFSELISQYSDEE

CASR

236

P41180
FEENTYCFGRTVETL

ACAD9

501

Q9H845
LNDLYTCFDAIIDNF

NPR2

886

P20594
FYELFTICTSIVAED

ASAH1

136

Q13510
LNDLYTCFDAVIDNF

NPR1

901

P16066
DDLIIDFDSFISCFL

CAPN11

691

Q9UMQ6
QLFCLEYEADSGEVT

C2orf68

106

Q2NKX9
IASETEIAFFCEEDY

C2orf76

101

Q3KRA6
YQTDEQDFTSCFIET

DISP1

841

Q96F81
FTNTCAADSEIELAY

CLIC5

386

Q9NZA1
GFSCEEDFIYENVES

ANO8

141

Q9HCE9
FEELLQASDVDYCVA

CDK5RAP2

1281

Q96SN8
YNICFELEDSNEIFT

PDS5B

141

Q9NTI5
SETLTEQDLQLYCDF

JAK2

306

O60674
LYCFDISFIEQSTEE

NUP205

276

Q92621
SNLSFVDLCYFSDIV

OR5I1

66

Q13606
LNISFNEFTCLDDVY

LRRC9

721

Q6ZRR7
EFDCAFRLAQEGIYT

NSUN2

596

Q08J23
SSTEDFCYVFTVELE

RADIL

966

Q96JH8
ISDDEFQVDVCAYNF

OVOS1

216

Q6IE37
QEVYACSIFENEDFL

PADI4

306

Q9UM07
FLYDEIEAEVNLCFD

CYFIP1

686

Q7L576
ELQDEAYTLIDFFCE

FHDC1

421

Q9C0D6
DYDNFLFLCLQDTTT

PAEP

116

P09466
ELVCADTFLFEIYAF

OR10A3

186

P58181
VTDYTFEDCQLALAE

LPCAT1

306

Q8NF37
FLVYTNDDEGCQAFL

PARP15

246

Q460N3
DFLISSETCFLEYFV

LINS1

511

Q8NG48
VIDAYFFLAANCTED

EYS

496

Q5T1H1
DFTVCVTDEGQLYAF

NEK9

436

Q8TD19
TELEDGFYLTAFICF

MFSD9

191

Q8NBP5
DYSDDFELCGDVTLQ

KATNIP

156

O60303
YDDFVANCTIQFEEL

PRKCE

91

Q02156
YLSEEETEQLCATLF

DOP1B

766

Q9Y3R5
FEFDSIYLGDIASLC

LOXHD1

1861

Q8IVV2
DLTCNDYISVFEFDI

CBLB

221

Q13191
DCYSLLDDQDFTSFD

FAM199X

96

Q6PEV8
YTPNDECFFIFLDVS

FBXW5

466

Q969U6
FCTFREDYDDISNQI

NADK

161

O95544
EVFEDAFEQEYTRVC

PCNX4

701

Q63HM2
ACSYEFINEIALAAF

OR14J1

186

Q9UGF5
ASYAEENECFFELEV

PCDH9

101

Q9HC56
FLQDCAEIADFFTEL

PGS1

251

Q32NB8
IYEFHFSDLECTELD

PDE6B

501

P35913
LDEDTLFCQGLEVFY

PEBP4

36

Q96S96
NFDISCLISAEDFVD

HERC6

331

Q8IVU3
ASFVEQDNFCIITEY

NEK11

96

Q8NG66
SDCFEVDQLLYFEEQ

NEK11

616

Q8NG66
DTVDFLSLDLSYECQ

LCT

241

P09848
LDELCVFAFGQEADY

KCNS1

126

Q96KK3
DDYDVTCNEFFFDRN

KCNG1

106

Q9UIX4
DVDAESFEVLVDYCY

KBTBD7

116

Q8WVZ9
LVLYFDDEGFCDFLE

NRXN1

66

Q9ULB1
YLTQAAFFEEVCLDL

MEIOSIN

386

C9JSJ3
LEQFTFQEALEFCES

ACAN

586

P16112
DVFTFSEECYSAEVE

MYO15B

651

Q96JP2
YLESHQDCQFDVLEF

CUBN

2621

O60494
GTQDVDCDFIDFTYV

ATG101

51

Q9BSB4
DCDFIDFTYVRVSSE

ATG101

56

Q9BSB4
CEDFDSYLVQIFGSS

COL28A1

981

Q2UY09
TFTTFYEVDCDVIDG

CTNNA2

816

P26232
FYETEELFEETLCSA

CCR3

171

P51677
FILAFENAVCDDYIT

FUT10

276

Q6P4F1
TFLVSCVDYDILFAN

ATG9A

81

Q7Z3C6
AALYTDAFNEVIDDF

CYP27A1

171

Q02318
DALEIEACQVYFTYD

IL2RB

371

P14784
AYSDLAEFLETECYQ

IFIT3

331

O14879
DLVCFEELTDYQLVS

DDX24

46

Q9GZR7
TDECFFFERLESNNY

FGF2

231

P09038
FETVLDALFLCFAVD

SLC44A3

586

Q8N4M1
TCNDYISVFEFDIFT

CBL

231

P22681
ESEECVFLEANSYLS

CCDC168

6791

Q8NDH2
TEFDYDLCNEVVDVT

FSHR

331

P23945
SNAVDIICVTVEDYF

EXOC3

566

O60645
YEIDFDVEIQATDIC

CFAP47

1836

Q6ZTR5
FFFCDTIEENEEAEA

PERM1

586

Q5SV97
TCTRFTDDYQLFEEL

CAMK2G

6

Q13555
LLSFAVESECTFLDY

CPNE5

306

Q9HCH3
DVDAESFEVLVDYCY

KBTBD6

116

Q86V97
TCTRFTDEYQLFEEL

CAMK2D

6

Q13557
SEDYLLLACDGFFDV

PPM1F

351

P49593
ELACADTFLFEIYAF

OR10A6

186

Q8NH74
FDDTLVAIDTYNCDL

HNRNPUL1

206

Q9BUJ2
GEYSTCFTELQRDFI

OAS3

921

Q9Y6K5
FLCLLGVSYTFDNED

MIA2

116

Q96PC5
VLHNSDDFQIYFCTE

MAP3K5

626

Q99683
DDFQIYFSTEEQCSR

MAP3K15

601

Q6ZN16
FERDSAAVCLSEDLY

SYDE1

451

Q6ZW31
TLCDYIYELATAFTE

RARS1

596

P54136
LSEDQDSYLCNVTLF

ATP6V1C1

216

P21283
SFSQTCLTQFLEDEY

MRPL44

131

Q9H9J2
TELDECIQYFTSLAL

SERAC1

221

Q96JX3
FSEFEIEQHQECAYD

TLL1

816

O43897
EYLDILAISCDSFDE

RSAD2

171

Q8WXG1
FLEDTACFYLAEITL

RPS6KB2

166

Q9UBS0
DLEEQLYCSAFEEAA

LMBR1L

236

Q6UX01
VASCFVERSQEFDIY

PLEKHG3

166

A1L390
YASIFFLVCLFETES

FBXL18

746

Q96ME1
LSLCDDYEEQTDEYF

KCNV2

136

Q8TDN2
IVTVEDFDVSDCFQY

SRGAP2C

401

P0DJJ0
VTVEDFDVSDCFQYS

SRGAP2B

401

P0DMP2
EIVCSEYQENFLSFS

TMEM150C

221

B9EJG8
CTRFTEEYQLFEELG

CAMK2A

6

Q9UQM7
EDLYYQACVFDLLTT

RGMA

371

Q96B86
AEVGDLFYDCVDTEI

SCRN1

396

Q12765
FEDSLFEECYFEDVT

SV2A

526

Q7L0J3
DYFSLDTDSFCTVLE

TLK2

531

Q86UE8
SVSLLTNFEDVCDYL

AMMECR1

216

Q9Y4X0
LISYQEFLAFESVLC

SLC25A12

71

O75746
YASRTNQECFEEAFL

NCAPG

761

Q9BPX3
GFTQYLLSSECDIFD

PLCL1

376

Q15111
NENYDLVFVEAFDFC

UGT3A1

136

Q6NUS8
EQFLDDSTALYTFAE

PLEK2

211

Q9NYT0
FRYLLETECNFLFTD

SETDB2

206

Q96T68
DFCYGNEDLTFSISE

UNC80

2331

Q8N2C7
YSRIADQCDFEEFVS

NME8

201

Q8N427
EVERTYSANCSDFLE

SPATS1

41

Q496A3
ADETFCIDNEALYDI

TUBB8

196

Q3ZCM7
ESAVNVVDCFFYDGI

TBC1D8B

661

Q0IIM8
NACIRFVYFSLEDEL

TMEM94

846

Q12767
VDSSQFSEYVLCREE

KCTD15

251

Q96SI1
ESYFDVVVIDECAQA

IGHMBP2

366

P38935
YISQCDEVLQFFETR

SH3PXD2B

111

A1X283
LEYLSAFDEETTEVC

RNF10

421

Q8N5U6
CVTFEDIAIYFSQDE

ZIK1

26

Q3SY52
DAVLFSSDDVTYCDA

SCTR

196

P47872
IVTVEDFDVSDCFQY

SRGAP2

401

O75044
ADETFCIDNEALYDI

TUBB8B

196

A6NNZ2
SNCEYFVDSLFEEAQ

UBXN2A

31

P68543
VVSDDFLADQAACYV

XRN1

446

Q8IZH2
YICSTLNDFQEERDF

TTC41P

26

Q6P2S7
AELLVSGDENCAYFE

RASD2

156

Q96D21
NACFESVATNIDEIY

SMC1A

1071

Q14683
GLYTCNVSREFEFEA

SCN3B

116

Q9NY72
VSITDYVVFDQCSLF

TECPR2

1026

O15040
ITFDEILQAYCFILE

RLBP1

171

P12271
YTSCVEKTDFEEFFL

UQCC1

121

Q9NVA1
LCSATAEFEDFVLQF

PSME4

536

Q14997
GCVTFEDVAIYFSQE

ZNF416

26

Q9BWM5
DTEVLFCFEQFDELT

TRAP1

521

Q12931
EFDLNDETLEYECFG

USP24

1996

Q9UPU5
TSLQACFISLEDLYE

SLC9C2

966

Q5TAH2
CFISLEDLYEGFDAF

SLC9C2

971

Q5TAH2
AECFVQRSEDFDIYT

PLEKHG2

176

Q9H7P9
FEDLAVYFSQEECVT

ZNF597

16

Q96LX8
VELFTECYSSDEDLA

TRPM8

626

Q7Z2W7
GFSSYLLDITEEDCF

TRMT10B

186

Q6PF06
EFDDVLLYNFFTDSE

TRANK1

1571

O15050
EEYFARQISSFCSID

UBR4

1091

Q5T4S7
FCEQSELDDLEYIYD

USP40

276

Q9NVE5
YFDLIGCDFLIDDNF

TTLL10

491

Q6ZVT0
YSADAVCFDVDSTVI

PSPHP1

36

O15172
DCYQDSVTFDDVAVD

ZNF426

36

Q9BUY5
GSVFQEYDTDCEVFR

ZNF449

16

Q6P9G9
LFCDVSIYINDTEFQ

ZBTB6

31

Q15916
FDCITTDFVLYQTLA

LGI3

216

Q8N145
LEFFSCLYEIQEEEF

NLRP12

611

P59046
AYCSREEAEVLFAEA

GRIN2C

226

Q14957
TVEDEGNYTCEFATF

NECTIN2

131

Q92692