Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	L-leucine binding	SESN3 SESN2 SESN1	2.06e-06	7	79	3	GO:0070728
GeneOntologyMolecularFunction	glucan 1,4-alpha-glucosidase activity	MGAM MGAM2	1.55e-05	2	79	2	GO:0004339
GeneOntologyMolecularFunction	alpha-1,4-glucosidase activity	MGAM MGAM2	1.53e-04	5	79	2	GO:0004558
GeneOntologyMolecularFunction	actin filament binding	PPP1R9A CAPZB PSTPIP1 MYO15A CNN3 ADD3	2.81e-04	227	79	6	GO:0051015
GeneOntologyMolecularFunction	nuclear androgen receptor binding	PRPF6 AR EP300	2.99e-04	33	79	3	GO:0050681
GeneOntologyMolecularFunction	alpha-glucosidase activity	MGAM MGAM2	3.20e-04	7	79	2	GO:0090599
GeneOntologyMolecularFunction	kinase binding	SLC12A6 TRADD PTPN14 SASH1 PIK3R2 PARP8 PPP1R9A CLTC PRKN GNAT1 EP300 ADD3	4.05e-04	969	79	12	GO:0019900
GeneOntologyMolecularFunction	protein kinase binding	SLC12A6 TRADD PTPN14 SASH1 PIK3R2 PPP1R9A CLTC PRKN GNAT1 EP300 ADD3	6.25e-04	873	79	11	GO:0019901
GeneOntologyBiologicalProcess	cellular response to L-leucine	SESN3 SESN2 SESN1 EP300	1.54e-07	13	81	4	GO:0071233
GeneOntologyBiologicalProcess	response to L-leucine	SESN3 SESN2 SESN1 EP300	3.87e-07	16	81	4	GO:0043201
GeneOntologyBiologicalProcess	actin polymerization or depolymerization	ABI1 PIK3R2 PPP1R9A CAPZB TENM1 PSTPIP1 PREX1 ADD3	2.60e-06	222	81	8	GO:0008154
GeneOntologyBiologicalProcess	actin filament organization	ABI1 PIK3R2 PPP1R9A CAPZB TENM1 PRKN PSTPIP1 MYO15A PREX1 CNN3 ADD3	4.73e-06	509	81	11	GO:0007015
GeneOntologyBiologicalProcess	actin filament polymerization	PIK3R2 PPP1R9A CAPZB TENM1 PSTPIP1 PREX1 ADD3	9.86e-06	190	81	7	GO:0030041
GeneOntologyBiologicalProcess	cellular response to leucine starvation	SESN3 SESN2 SESN1	1.25e-05	12	81	3	GO:1990253
GeneOntologyBiologicalProcess	negative regulation of spontaneous neurotransmitter secretion	PPP1R9A PRKN	1.52e-05	2	81	2	GO:1904049
GeneOntologyBiologicalProcess	negative regulation of primary amine oxidase activity	AOC3 PRKN	1.52e-05	2	81	2	GO:1902283
GeneOntologyBiologicalProcess	regulation of response to reactive oxygen species	SESN3 SESN2 SESN1	1.62e-05	13	81	3	GO:1901031
GeneOntologyBiologicalProcess	regulation of autophagy	PIK3R2 MTMR8 SESN3 PRKN SESN2 SESN1 EP300 EXOC8 TPCN1	2.70e-05	400	81	9	GO:0010506
GeneOntologyBiologicalProcess	regulation of actin filament polymerization	PIK3R2 PPP1R9A CAPZB TENM1 PREX1 ADD3	3.46e-05	156	81	6	GO:0030833
GeneOntologyBiologicalProcess	regulation of response to oxidative stress	SESN3 PRKN SESN2 SESN1	3.46e-05	47	81	4	GO:1902882
GeneOntologyBiologicalProcess	regulation of spontaneous neurotransmitter secretion	PPP1R9A PRKN	4.56e-05	3	81	2	GO:1904048
GeneOntologyBiologicalProcess	process utilizing autophagic mechanism	PIK3R2 CLTC MTMR8 NAGLU SESN3 PRKN SESN2 SESN1 EP300 EXOC8 TPCN1	4.58e-05	650	81	11	GO:0061919
GeneOntologyBiologicalProcess	autophagy	PIK3R2 CLTC MTMR8 NAGLU SESN3 PRKN SESN2 SESN1 EP300 EXOC8 TPCN1	4.58e-05	650	81	11	GO:0006914
GeneOntologyBiologicalProcess	protein polymerization	PIK3R2 PPP1R9A CAPZB TENM1 PRKN PSTPIP1 PREX1 ADD3	5.01e-05	334	81	8	GO:0051258
GeneOntologyBiologicalProcess	actin cytoskeleton organization	ABI1 PIK3R2 PPP1R9A CAPZB TENM1 PRKN PSTPIP1 MYO15A PREX1 EP300 CNN3 ADD3	6.69e-05	803	81	12	GO:0030036
GeneOntologyBiologicalProcess	regulation of actin polymerization or depolymerization	PIK3R2 PPP1R9A CAPZB TENM1 PREX1 ADD3	6.99e-05	177	81	6	GO:0008064
GeneOntologyBiologicalProcess	regulation of actin filament length	PIK3R2 PPP1R9A CAPZB TENM1 PREX1 ADD3	7.67e-05	180	81	6	GO:0030832
GeneOntologyBiologicalProcess	regulation of macroautophagy	MTMR8 SESN3 PRKN SESN2 SESN1 EXOC8	9.19e-05	186	81	6	GO:0016241
GeneOntologyBiologicalProcess	regulation of actin cytoskeleton organization	PIK3R2 PPP1R9A CAPZB TENM1 PRKN PREX1 EP300 ADD3	1.32e-04	384	81	8	GO:0032956
GeneOntologyBiologicalProcess	reactive oxygen species metabolic process	ABCB7 NAGLU PRKN SESN2 PREX1 SESN1 NDUFS1	1.48e-04	291	81	7	GO:0072593
GeneOntologyBiologicalProcess	regulation of actin filament organization	PIK3R2 PPP1R9A CAPZB TENM1 PRKN PREX1 ADD3	1.78e-04	300	81	7	GO:0110053
GeneOntologyBiologicalProcess	actin filament-based process	ABI1 PIK3R2 PPP1R9A CAPZB TENM1 PRKN PSTPIP1 MYO15A PREX1 EP300 CNN3 ADD3	2.21e-04	912	81	12	GO:0030029
GeneOntologyBiologicalProcess	regulation of cellular component size	SLC12A6 PIK3R2 PPP1R9A CAPZB TENM1 PREX1 EP300 ADD3	2.67e-04	426	81	8	GO:0032535
GeneOntologyBiologicalProcess	regulation of protein polymerization	PIK3R2 PPP1R9A CAPZB TENM1 PREX1 ADD3	2.98e-04	231	81	6	GO:0032271
GeneOntologyBiologicalProcess	regulation of spontaneous synaptic transmission	PPP1R9A PRKN	3.16e-04	7	81	2	GO:0150003
GeneOntologyBiologicalProcess	regulation of actin filament-based process	PIK3R2 PPP1R9A CAPZB TENM1 PRKN PREX1 EP300 ADD3	3.22e-04	438	81	8	GO:0032970
GeneOntologyBiologicalProcess	regulation of supramolecular fiber organization	PIK3R2 PPP1R9A CAPZB TENM1 PRKN PREX1 EP300 ADD3	3.22e-04	438	81	8	GO:1902903
GeneOntologyBiologicalProcess	supramolecular fiber organization	ABI1 PIK3R2 PPP1R9A CAPZB TENM1 PRKN PSTPIP1 MYO15A PREX1 EP300 CNN3 ADD3	3.43e-04	957	81	12	GO:0097435
GeneOntologyBiologicalProcess	cellular response to amino acid stimulus	SESN3 PRKN SESN2 SESN1 EP300	4.33e-04	161	81	5	GO:0071230
GeneOntologyBiologicalProcess	regulation of cytoskeleton organization	PIK3R2 PPP1R9A CLTC CAPZB TENM1 PRKN PREX1 EP300 ADD3	4.40e-04	579	81	9	GO:0051493
GeneOntologyBiologicalProcess	positive regulation of macroautophagy	SESN3 PRKN SESN2 SESN1	4.74e-04	92	81	4	GO:0016239
GeneOntologyBiologicalProcess	intrinsic apoptotic signaling pathway by p53 class mediator	BRCA2 PRKN USP15 EP300	4.94e-04	93	81	4	GO:0072332
GeneOntologyBiologicalProcess	negative regulation of neurotransmitter secretion	PPP1R9A PRKN	5.39e-04	9	81	2	GO:0046929
GeneOntologyBiologicalProcess	positive regulation of autophagy	SESN3 PRKN SESN2 SESN1 TPCN1	6.00e-04	173	81	5	GO:0010508
GeneOntologyBiologicalProcess	cellular response to acid chemical	SESN3 PRKN SESN2 SESN1 EP300	6.65e-04	177	81	5	GO:0071229
GeneOntologyBiologicalProcess	enzyme-linked receptor protein signaling pathway	EPHB6 TRADD FAT4 ABI1 FBN1 IGF2R PIK3R2 SESN3 ACVR1C USP15 CDH3 AR EP300	6.85e-04	1186	81	13	GO:0007167
GeneOntologyBiologicalProcess	regulation of TORC1 signaling	SESN3 SESN2 SESN1 EP300	7.00e-04	102	81	4	GO:1903432
GeneOntologyBiologicalProcess	regulation of anatomical structure size	SLC12A6 PIK3R2 PPP1R9A CAPZB TENM1 BBS2 PREX1 EP300 ADD3	7.02e-04	618	81	9	GO:0090066
GeneOntologyBiologicalProcess	behavior	C1QL1 NAGLU AOC3 SLITRK5 BBS2 PRKN GNAT1 MYO15A AR EP300 PREX2	7.02e-04	891	81	11	GO:0007610
GeneOntologyBiologicalProcess	cellular response to chemical stress	MSRA SLC12A6 NAGLU PRKN SESN2 USP15 EP300	7.02e-04	377	81	7	GO:0062197
GeneOntologyCellularComponent	GATOR2 complex	SESN3 SESN2 SESN1	1.20e-05	12	81	3	GO:0061700
GeneOntologyCellularComponent	Seh1-associated complex	SESN3 SESN2 SESN1	3.03e-05	16	81	3	GO:0035859
Domain	AhpD-like	SESN3 SESN2 SESN1	7.28e-08	3	79	3	IPR029032
Domain	PA26	SESN3 SESN2 SESN1	7.28e-08	3	79	3	PF04636
Domain	Sestrin	SESN3 SESN2 SESN1	7.28e-08	3	79	3	IPR006730
Domain	-	SESN3 SESN2 SESN1	7.28e-08	3	79	3	1.20.1290.10
Domain	YD	NID2 TENM4 TENM1	7.24e-07	5	79	3	IPR006530
Domain	SAM_2	EPHB6 SAMD9 SASH1 PPP1R9A	3.23e-05	43	79	4	PF07647
Domain	Tox-GHH_dom	TENM4 TENM1	1.05e-04	4	79	2	IPR028916
Domain	Ten_N	TENM4 TENM1	1.05e-04	4	79	2	IPR009471
Domain	Ten_N	TENM4 TENM1	1.05e-04	4	79	2	PF06484
Domain	TENEURIN_N	TENM4 TENM1	1.05e-04	4	79	2	PS51361
Domain	NtCtMGAM_N	MGAM MGAM2	1.05e-04	4	79	2	PF16863
Domain	Gal_mutarotase_N	MGAM MGAM2	1.05e-04	4	79	2	IPR031727
Domain	Tox-GHH	TENM4 TENM1	1.05e-04	4	79	2	PF15636
Domain	Glyco_hydro_31_AS	MGAM MGAM2	2.62e-04	6	79	2	IPR030458
Domain	Glyco_hydro_31	MGAM MGAM2	3.66e-04	7	79	2	IPR000322
Domain	Glyco_hydro_31	MGAM MGAM2	3.66e-04	7	79	2	PF01055
Domain	GLYCOSYL_HYDROL_F31_1	MGAM MGAM2	3.66e-04	7	79	2	PS00129
Domain	EGF_3	NID2 FAT4 FBN1 TENM4 TENM1 HABP2	4.81e-04	235	79	6	PS50026
Domain	EGF	NID2 FAT4 FBN1 TENM4 TENM1 HABP2	4.81e-04	235	79	6	SM00181
Domain	Trefoil	MGAM MGAM2	4.87e-04	8	79	2	PF00088
Domain	SAM	EPHB6 SAMD9 SASH1 PPP1R9A	5.28e-04	88	79	4	SM00454
Domain	-	NID2 TENM4 TENM1	5.96e-04	39	79	3	2.120.10.30
Domain	P_TREFOIL_2	MGAM MGAM2	6.24e-04	9	79	2	PS51448
Domain	PD	MGAM MGAM2	6.24e-04	9	79	2	SM00018
Domain	EGF-like_dom	NID2 FAT4 FBN1 TENM4 TENM1 HABP2	6.52e-04	249	79	6	IPR000742
Domain	SAM_DOMAIN	EPHB6 SAMD9 SASH1 PPP1R9A	7.05e-04	95	79	4	PS50105
Domain	SAM	EPHB6 SAMD9 SASH1 PPP1R9A	7.62e-04	97	79	4	IPR001660
Domain	EGF-like_CS	NID2 FAT4 FBN1 TENM4 TENM1 HABP2	8.33e-04	261	79	6	IPR013032
Domain	EGF_2	NID2 FAT4 FBN1 TENM4 TENM1 HABP2	9.02e-04	265	79	6	PS01186
Domain	-	MGAM MGAM2	9.48e-04	11	79	2	4.10.110.10
Domain	6-blade_b-propeller_TolB-like	NID2 TENM4 TENM1	9.70e-04	46	79	3	IPR011042
Domain	-	EPHB6 SAMD9 SASH1 PPP1R9A	1.06e-03	106	79	4	1.10.150.50
Domain	P_trefoil_dom	MGAM MGAM2	1.13e-03	12	79	2	IPR000519
Domain	NHL	TENM4 TENM1	1.34e-03	13	79	2	PS51125
Domain	Glycoside_hydrolase_SF	MGAM NAGLU MGAM2	1.47e-03	53	79	3	IPR017853
Domain	SAM/pointed	EPHB6 SAMD9 SASH1 PPP1R9A	1.53e-03	117	79	4	IPR013761
Domain	EGF_CA	NID2 FAT4 FBN1 HABP2	1.78e-03	122	79	4	SM00179
Domain	EGF-like_Ca-bd_dom	NID2 FAT4 FBN1 HABP2	1.89e-03	124	79	4	IPR001881
Domain	SH3	ABI1 SASH1 PIK3R2 PSTPIP1 MYO15A	2.22e-03	216	79	5	SM00326
Domain	SH3	ABI1 SASH1 PIK3R2 PSTPIP1 MYO15A	2.22e-03	216	79	5	PS50002
Domain	Gal_mutarotase_SF_dom	MGAM MGAM2	2.31e-03	17	79	2	IPR011013
Domain	SH3_domain	ABI1 SASH1 PIK3R2 PSTPIP1 MYO15A	2.41e-03	220	79	5	IPR001452
Domain	DEP	PREX1 PREX2	3.86e-03	22	79	2	PF00610
Domain	DEP	PREX1 PREX2	3.86e-03	22	79	2	PS50186
Domain	DEP	PREX1 PREX2	3.86e-03	22	79	2	SM00049
Domain	DEP_dom	PREX1 PREX2	4.22e-03	23	79	2	IPR000591
Pathway	REACTOME_RHO_GTPASE_CYCLE	ABI1 FAM13A PIK3R2 CLTC CAPZB SLITRK5 FAM135A PREX1 PREX2 ADD3	2.99e-05	439	65	10	MM15595
Pathway	REACTOME_RHO_GTPASE_CYCLE	ABI1 FAM13A PIK3R2 CLTC CAPZB SLITRK5 FAM135A PREX1 PREX2 ADD3	3.69e-05	450	65	10	M27078
Pubmed	Sestrin1, 2, and 3 are dispensable for female fertility in mice.	SESN3 SESN2 SESN1	1.22e-08	3	81	3	38297375
Pubmed	PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse.	SESN3 SESN2 SESN1	1.22e-08	3	81	3	12607115
Pubmed	Sestrins are evolutionarily conserved mediators of exercise benefits.	SESN3 SESN2 SESN1	1.22e-08	3	81	3	31929512
Pubmed	Circulating Sestrin Levels Are Increased in Hypertension Patients.	SESN3 SESN2 SESN1	1.22e-08	3	81	3	32626541
Pubmed	Interactions between microRNA-200 family and Sestrin proteins in endometrial cancer cell lines and their significance to anoikis.	SESN3 SESN2 SESN1	1.22e-08	3	81	3	31073887
Pubmed	The functions and roles of sestrins in regulating human diseases.	SESN3 SESN2 SESN1	1.22e-08	3	81	3	34979914
Pubmed	Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3.	SESN3 SESN2 SESN1	4.86e-08	4	81	3	22958918
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	SLC12A6 ABI1 PTPN14 IGF2R SASH1 PIK3R2 PPP1R9A SEC63 FAM135A ADD3	5.31e-08	421	81	10	36976175
Pubmed	Sestrin2 is a leucine sensor for the mTORC1 pathway.	SESN3 SESN2 SESN1	1.21e-07	5	81	3	26449471
Pubmed	Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.	SESN3 SESN2 SESN1	4.23e-07	7	81	3	25259925
Pubmed	The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1.	SESN3 SESN2 SESN1	2.64e-06	12	81	3	25263562
Pubmed	Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase.	PREX1 PREX2	5.36e-06	2	81	2	20694145
Pubmed	Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies.	SESN2 SESN1	5.36e-06	2	81	2	20203043
Pubmed	Acetylation of Abelson interactor 1 at K416 regulates actin cytoskeleton and smooth muscle contraction.	ABI1 EP300	5.36e-06	2	81	2	34369620
Pubmed	P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination.	PREX1 PREX2	5.36e-06	2	81	2	18334636
Pubmed	Identification of the functional domains of ANT-1, a novel coactivator of the androgen receptor.	PRPF6 AR	5.36e-06	2	81	2	16414017
Pubmed	Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine.	SESN2 SESN1	5.36e-06	2	81	2	35771919
Pubmed	P-Rex1 and P-Rex2 RacGEFs and cancer.	PREX1 PREX2	5.36e-06	2	81	2	28710285
Pubmed	The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy.	PRKN USP15	5.36e-06	2	81	2	24852371
Pubmed	Cardioprotective roles of sestrin 1 and sestrin 2 against doxorubicin cardiotoxicity.	SESN2 SESN1	5.36e-06	2	81	2	31026186
Pubmed	Sestrins orchestrate cellular metabolism to attenuate aging.	SESN3 SESN2	5.36e-06	2	81	2	24055102
Pubmed	[A study of recombinant human sestrin 1 and sestrin 2 proteins produced in a prokaryotic system].	SESN2 SESN1	5.36e-06	2	81	2	28707664
Pubmed	Splicing factor PRPF6 upregulates oncogenic androgen receptor signaling pathway in hepatocellular carcinoma.	PRPF6 AR	5.36e-06	2	81	2	32745318
Pubmed	Sestrins induce natural killer function in senescent-like CD8+ T cells.	SESN3 SESN1	5.36e-06	2	81	2	32231301
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	ENDOD1 ABCB7 GTF2I PIK3R2 CLTC SESN2 HCFC2 SEC63 NDUFS1 EP300 PREX2 ASF1A NXF1	1.15e-05	1327	81	13	32694731
Pubmed	The androgen receptor and genetic susceptibility to ovarian cancer: results from a case series.	BRCA2 AR	1.60e-05	3	81	2	11221880
Pubmed	Identification of SEPTIN12 as a novel target of the androgen and estrogen receptors in human testicular cells.	AR SEPTIN12	1.60e-05	3	81	2	30513371
Pubmed	Melanoma antigen-A11 (MAGE-A11) enhances transcriptional activity by linking androgen receptor dimers.	AR EP300	1.60e-05	3	81	2	23172223
Pubmed	CAG and GGC repeat polymorphisms in the androgen receptor gene and breast cancer susceptibility in BRCA1/2 carriers and non-carriers.	BRCA2 AR	1.60e-05	3	81	2	11437399
Pubmed	Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling.	SESN3 SESN2	1.60e-05	3	81	2	25377878
Pubmed	Fibrillin-1, induced by Aurora-A but inhibited by BRCA2, promotes ovarian cancer metastasis.	FBN1 BRCA2	1.60e-05	3	81	2	25749384
Pubmed	Androgen receptor CAG repeat length in Jewish Israeli women who are BRCA1/2 mutation carriers: association with breast/ovarian cancer phenotype.	BRCA2 AR	1.60e-05	3	81	2	12404104
Pubmed	Androgen pathway dysregulation in BRCA1-mutated breast tumors.	BRCA2 AR	1.60e-05	3	81	2	12779088
Pubmed	Impact of androgen receptor cytosine-adenine-guanine polymorphisms on clinical outcome in BRCA mutation-associated epithelial ovarian cancers.	BRCA2 AR	1.60e-05	3	81	2	19818997
Pubmed	Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis.	SESN3 SESN2	1.60e-05	3	81	2	26913956
Pubmed	Genetic variations in a Sestrin2/Sestrin3/mTOR Axis and development of new-onset diabetes after kidney transplantation.	SESN3 SESN2	1.60e-05	3	81	2	37918578
Pubmed	Acetylation of beta-catenin by p300 regulates beta-catenin-Tcf4 interaction.	AR EP300	1.60e-05	3	81	2	15060161
Pubmed	p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis.	SESN2 SESN1	1.60e-05	3	81	2	31857853
Pubmed	Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.	ENDOD1 DNAJC13 ABCB7 PTPN14 IGF2R PIGK SEC63 EP300	2.18e-05	499	81	8	22810586
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	SLC12A6 DNAJC13 IGF2R PIGK PIK3R2 TENM1 SEC63 FAM135A	2.34e-05	504	81	8	34432599
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	NID2 ENDOD1 ABCB7 PTPN14 FBN1 IGF2R PIGK CLTC NAGLU PRPF6 SEC63 NDUFS1 EP300	2.94e-05	1451	81	13	30550785
Pubmed	USP33 deubiquitinates PRKN/parkin and antagonizes its role in mitophagy.	PRKN USP15	3.20e-05	4	81	2	31432739
Pubmed	Mouse ten-m/Odz is a new family of dimeric type II transmembrane proteins expressed in many tissues.	TENM4 TENM1	3.20e-05	4	81	2	10225957
Pubmed	Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD.	SESN2 SESN1	3.20e-05	4	81	2	15105503
Pubmed	Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor.	PRPF6 AR	3.20e-05	4	81	2	12039962
Pubmed	C1q/tumor necrosis factor-related protein 11 (CTRP11), a novel adipose stroma-derived regulator of adipogenesis.	C1QL1 C1QL4	3.20e-05	4	81	2	23449976
Pubmed	Structural Insights of Transcriptionally Active, Full-Length Androgen Receptor Coactivator Complexes.	AR EP300	3.20e-05	4	81	2	32668201
Pubmed	Rho GEFs and cancer: linking gene expression and metastatic dissemination.	PREX1 PREX2	3.20e-05	4	81	2	23033535
Pubmed	p300 acetyltransferase regulates androgen receptor degradation and PTEN-deficient prostate tumorigenesis.	AR EP300	3.20e-05	4	81	2	24480624
Pubmed	Transcriptional synergy between melanoma antigen gene protein-A11 (MAGE-11) and p300 in androgen receptor signaling.	AR EP300	3.20e-05	4	81	2	20448036
Pubmed	All four members of the Ten-m/Odz family of transmembrane proteins form dimers.	TENM4 TENM1	3.20e-05	4	81	2	12000766
Pubmed	Ovarian cancer and polymorphisms in the androgen and progesterone receptor genes: a HuGE review.	BRCA2 AR	3.20e-05	4	81	2	14769635
Pubmed	p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation.	AR EP300	3.20e-05	4	81	2	10779504
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	MSRA SLC12A6 ENDOD1 PHYKPL DNAJC13 GTF2I FAM13A PPP1R9A PRKN USP15 SESN1 AR EP300	3.84e-05	1489	81	13	28611215
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	PTPN14 GTF2I CLTC CAPZB USP15 EP300 CNN3 ADD3	4.29e-05	549	81	8	38280479
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	ABCB7 ABI1 GTF2I CLTC PRPF6 NDUFS1 CNN3 EXOC8	4.93e-05	560	81	8	35241646
Pubmed	Placing the HIRA histone chaperone complex in the chromatin landscape.	GTF2I EP300 ASF1A	5.22e-05	31	81	3	23602572
Pubmed	p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling.	SESN2 SESN1	5.33e-05	5	81	2	18692468
Pubmed	Prohibitin and the SWI/SNF ATPase subunit BRG1 are required for effective androgen antagonist-mediated transcriptional repression of androgen receptor-regulated genes.	AR EP300	5.33e-05	5	81	2	18487222
Pubmed	The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins.	C1QL1 C1QL4	5.33e-05	5	81	2	21262840
Pubmed	SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation.	PRKN SESN2	5.33e-05	5	81	2	29330382
Pubmed	Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor.	IGF2R CLTC	5.33e-05	5	81	2	11387476
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	ENDOD1 ABI1 PTPN14 IGF2R PPP1R9A GNAT1 FAM135A ADD3	5.51e-05	569	81	8	30639242
Pubmed	Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.	MSRA GTF2I PRKN PREX1	6.81e-05	93	81	4	27689697
Pubmed	P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation.	PREX1 PREX2	7.99e-05	6	81	2	25538043
Pubmed	JS-K, a nitric oxide pro-drug, regulates growth and apoptosis through the ubiquitin-proteasome pathway in prostate cancer cells.	AR EP300	7.99e-05	6	81	2	28549433
Pubmed	Distinct expression of C1q-like family mRNAs in mouse brain and biochemical characterization of their encoded proteins.	C1QL1 C1QL4	7.99e-05	6	81	2	20525073
Pubmed	Integrative genetic, genomic and transcriptomic analysis of heat shock protein and nuclear hormone receptor gene associations with spontaneous preterm birth.	SEC63 AR	7.99e-05	6	81	2	34429451
Pubmed	Recruitment of coregulator complexes to the beta-globin gene locus by TFII-I and upstream stimulatory factor.	GTF2I EP300	7.99e-05	6	81	2	17970752
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	FAT4 DNAJC13 GTF2I IGF2R CLTC SLITRK5 HCFC2 FAM135A ADD3	8.23e-05	777	81	9	35844135
Pubmed	Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ENDOD1 ZSWIM8 FAM13A SLITRK5	9.03e-05	100	81	4	10048485
Pubmed	Network organization of the huntingtin proteomic interactome in mammalian brain.	SLC12A6 SASH1 BRCA2 CAPZB PYGM GNAT1 NDUFS1 ADD3	1.01e-04	621	81	8	22794259
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	ENDOD1 FAT4 ABCB7 FBN1 IGF2R PIGK NAGLU SLITRK5 SEC63 USP15 TPCN1	1.06e-04	1201	81	11	35696571
Pubmed	P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses.	PREX1 PREX2	1.12e-04	7	81	2	21178006
Pubmed	P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration.	PREX1 PREX2	1.12e-04	7	81	2	17565979
Pubmed	Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals.	SESN2 SESN1	1.12e-04	7	81	2	31929511
Pubmed	The murine Ten-m/Odz genes show distinct but overlapping expression patterns during development and in adult brain.	TENM4 TENM1	1.12e-04	7	81	2	12915301
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	MSRA DNAJC13 MXRA5 ABI1 IGF2R SH3BGRL CLTC NAGLU CAPZB MYO15A	1.25e-04	1016	81	10	19056867
Pubmed	Host cell factors stimulate HIV-1 transcription by antagonizing substrate-binding function of Siah1 ubiquitin ligase to stabilize transcription elongation factor ELL2.	ELL2 HCFC2	1.49e-04	8	81	2	32479599
Pubmed	Identification of a novel K311 ubiquitination site critical for androgen receptor transcriptional activity.	AR EP300	1.49e-04	8	81	2	27903893
Pubmed	Mapping homologs of Drosophila odd Oz (odz): Doc4/Odz4 to mouse chromosome 7, Odz1 to mouse chromosome 11; and ODZ3 to human chromosome Xq25.	TENM4 TENM1	1.49e-04	8	81	2	10331952
Pubmed	Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.	SESN2 SESN1	1.49e-04	8	81	2	23274085
Pubmed	P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils.	PREX1 PREX2	1.49e-04	8	81	2	24659802
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DNAJC13 ABCB7 PTPN14 IGF2R PIK3R2 CLTC BBS2 PRPF6 SEC63 FAM135A NDUFS1 ADD3	1.64e-04	1487	81	12	33957083
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	ABI1 GTF2I CLTC CAPZB PRPF6 CNN3 ADD3	1.82e-04	506	81	7	30890647
Pubmed	Estrogen receptor (ER) beta or p53 attenuates ERalpha-mediated transcriptional activation on the BRCA2 promoter.	BRCA2 EP300	2.38e-04	10	81	2	18765668
Pubmed	Cartography of teneurin and latrophilin expression reveals spatiotemporal axis heterogeneity in the mouse hippocampus during development.	TENM4 TENM1	2.38e-04	10	81	2	38713721
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	ENDOD1 DNAJC13 ABI1 PTPN14 GTF2I CAPZB BBS2 PRPF6 USP15 NDUFS1 EXOC8	2.41e-04	1321	81	11	27173435
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	DNAJC13 PTPN14 TENM4 CSRNP3 CAPZB CNN3 ASF1A	2.58e-04	536	81	7	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	DNAJC13 PTPN14 TENM4 CSRNP3 CAPZB CNN3 ASF1A	2.64e-04	538	81	7	10512203
Pubmed	Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells.	ABI1 PIK3R2	2.91e-04	11	81	2	20598684
Pubmed	Transforming growth factor Beta2 is required for valve remodeling during heart development.	FBN1 HABP2	3.48e-04	12	81	2	21780244
Pubmed	Disruption of murine Adamtsl4 results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiation.	FBN1 CDH3	3.48e-04	12	81	2	26405179
Pubmed	Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers.	EPHB6 CLTC CAPZB PRPF6 CNN3	3.56e-04	259	81	5	31162944
Pubmed	EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired.	PIK3R2 CLTC SESN2 EP300	4.27e-04	150	81	4	32423001
Pubmed	Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.	IGF2R BRCA2 PIK3R2 AOC3 EP300	4.76e-04	276	81	5	28319085
Pubmed	PRSS50 is a testis protease responsible for proper sperm tail formation and function.	AR SEPTIN12	4.79e-04	14	81	2	33913480
Pubmed	Inactivation of Mdm2 restores apoptosis proficiency of cooperativity mutant p53 in vivo.	SESN3 SESN2	4.79e-04	14	81	2	31749402
Pubmed	Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders.	ABCB7 IGF2R CAPZB NXF1	4.95e-04	156	81	4	29961565
Pubmed	Quantitative trait loci analysis reveals candidate genes implicated in regulating functional deficit and CNS vascular permeability in CD8 T cell-initiated blood-brain barrier disruption.	IGF2R PRKN	5.52e-04	15	81	2	24090483
Interaction	RND3 interactions	PTPN14 IGF2R PIK3R2 PPP1R9A CLTC CAPZB SLITRK5 FAM135A ADD3	1.21e-06	273	79	9	int:RND3
Interaction	RAC1 interactions	TRADD ABI1 PTPN14 IGF2R FAM13A PIK3R2 PPP1R9A CLTC CAPZB SLITRK5 PRKN HABP2 PREX1 NDUFS1 PREX2 ADD3	2.99e-06	1063	79	16	int:RAC1
Interaction	NPRL3 interactions	IGF2R SESN3 PRKN SESN2 AR EP300	3.35e-06	104	79	6	int:NPRL3
Interaction	CAV1 interactions	SLC12A6 ENDOD1 TRADD PTPN14 IGF2R PIK3R2 PPP1R9A CLTC PRKN FAM135A AR NXF1 ADD3	4.42e-06	724	79	13	int:CAV1
Interaction	RHOH interactions	SLC12A6 ABCB7 IGF2R PIK3R2 CLTC SLITRK5 PRKN FAM135A PREX1 NDUFS1 ADD3	4.86e-06	512	79	11	int:RHOH
Interaction	TRERF1 interactions	PRKN AR EP300 NXF1	8.21e-06	33	79	4	int:TRERF1
Interaction	CTTN interactions	ABI1 BRCA2 SH3BGRL PPP1R9A CAPZB PRKN PRPF6 EP300 ASF1A NXF1	1.01e-05	450	79	10	int:CTTN
Interaction	RHOF interactions	FAT4 ABCB7 IGF2R PIGK PIK3R2 PPP1R9A CLTC CAPZB SLITRK5 FAM135A NXF1 ADD3	1.15e-05	673	79	12	int:RHOF
Interaction	RHOA interactions	FAT4 ABCB7 PTPN14 IGF2R PIGK PIK3R2 PPP1R9A CLTC SLITRK5 SEC63 CDH3 FAM135A PREX1 NDUFS1 PREX2 ADD3	1.37e-05	1199	79	16	int:RHOA
Interaction	RHOB interactions	SLC12A6 FAT4 ABCB7 ABI1 PTPN14 IGF2R PIK3R2 PPP1R9A CLTC SLITRK5 FAM135A NDUFS1 ADD3	2.16e-05	840	79	13	int:RHOB
Interaction	EPHA2 interactions	EPHB6 SLC12A6 ABI1 PTPN14 IGF2R SASH1 PIK3R2 PPP1R9A CLTC SEC63 FAM135A ADD3	2.22e-05	719	79	12	int:EPHA2
Interaction	WDR24 interactions	CAPZB SESN3 SESN2 SESN1	2.40e-05	43	79	4	int:WDR24
Interaction	NELFA interactions	CAPZB PRKN AR ASF1A NXF1	2.47e-05	88	79	5	int:NELFA
Interaction	RAC3 interactions	FAT4 ABI1 IGF2R PIK3R2 PPP1R9A CLTC SLITRK5 PRKN FAM135A AR ADD3	2.85e-05	619	79	11	int:RAC3
Interaction	MCMBP interactions	GTF2I CAPZB PRKN EP300 NXF1 PRTFDC1	3.53e-05	157	79	6	int:MCMBP
Interaction	CSRNP3 interactions	CSRNP3 PRKN	4.54e-05	3	79	2	int:CSRNP3
Interaction	HIRA interactions	GTF2I CAPZB AR EP300 ASF1A NXF1	4.67e-05	165	79	6	int:HIRA
Interaction	RHOG interactions	SLC12A6 ABCB7 IGF2R TENM4 PIK3R2 PPP1R9A CLTC SLITRK5 PRKN FAM135A NDUFS1 PREX2 ADD3	4.95e-05	910	79	13	int:RHOG
Interaction	PRPSAP2 interactions	ABI1 SH3BGRL CAPZB PRKN USP15	5.04e-05	102	79	5	int:PRPSAP2
Interaction	CCAR2 interactions	TRADD ABI1 CLTC PRKN USP15 AR EP300 ASF1A	5.23e-05	337	79	8	int:CCAR2
Interaction	RBM14 interactions	ABI1 BRCA2 CLTC CAPZB PRKN PRPF6 USP15 AR EP300 CNN3	5.87e-05	553	79	10	int:RBM14
Interaction	DUS3L interactions	TRADD C1QL4 PRKN EP300	6.88e-05	56	79	4	int:DUS3L
Interaction	ABL1 interactions	ABI1 BRCA2 PIK3R2 PRKN PSTPIP1 AR EP300	7.04e-05	259	79	7	int:ABL1
Interaction	WASF3 interactions	ABI1 PIK3R2 CAPZB CNN3	7.38e-05	57	79	4	int:WASF3
Interaction	RHOD interactions	IGF2R PIK3R2 PPP1R9A CLTC CAPZB SLITRK5 SEC63 FAM135A NDUFS1 ADD3	7.78e-05	572	79	10	int:RHOD
Interaction	RAB35 interactions	SLC12A6 ABI1 PTPN14 IGF2R PIK3R2 PPP1R9A PRKN SEC63 FAM135A ADD3	7.89e-05	573	79	10	int:RAB35
Interaction	HSP90AB1 interactions	EPHB6 ENDOD1 GTF2I IGF2R BRCA2 HLA-DRB4 CAPZB PRKN TSHZ1 MYO15A USP15 AR NXF1	8.52e-05	960	79	13	int:HSP90AB1
Interaction	ALDH18A1 interactions	CAPZB PRKN USP15 PREX1 EP300 NXF1	9.90e-05	189	79	6	int:ALDH18A1
Interaction	FEN1 interactions	BRCA2 CAPZB PRKN AR EP300 NXF1	1.11e-04	193	79	6	int:FEN1
Interaction	FIG4 interactions	BRCA2 CAPZB PRKN	1.25e-04	25	79	3	int:FIG4
Interaction	SIM2 interactions	PRKN PREX1 ADD3	1.25e-04	25	79	3	int:SIM2
Interaction	SMARCC1 interactions	SAMD9 CAPZB PRKN USP15 AR EP300 ASF1A NXF1	1.30e-04	384	79	8	int:SMARCC1
Interaction	CDC73 interactions	CLTC CAPZB PRKN USP15 AR EP300 CNN3 NXF1	1.34e-04	386	79	8	int:CDC73
Interaction	STIP1 interactions	SLC12A6 DNAJC13 PTPN14 GTF2I CLTC MTMR8 CAPZB PRKN PRPF6 AR NDUFS1 EP300 ADD3	1.36e-04	1006	79	13	int:STIP1
Interaction	DNM2 interactions	ABI1 CLTC CAPZB PYGM PRKN PSTPIP1 EP300	1.36e-04	288	79	7	int:DNM2
Interaction	BECN1 interactions	CAPZB PRKN USP15 AR NXF1 EXOC8	1.39e-04	201	79	6	int:BECN1
Interaction	SRCAP interactions	BRCA2 PRKN AR EP300 ASF1A	1.43e-04	127	79	5	int:SRCAP
Interaction	OCLN interactions	DNAJC13 ABI1 PTPN14 IGF2R PIK3R2 PPP1R9A CLTC FAM135A ADD3	1.46e-04	500	79	9	int:OCLN
Interaction	TDG interactions	BRCA2 AR EP300 NXF1	1.56e-04	69	79	4	int:TDG
Interaction	SEC24C interactions	IGF2R CLTC PRKN NDUFS1 EP300 NXF1	1.63e-04	207	79	6	int:SEC24C
Interaction	MYO6 interactions	FAM13A SH3BGRL PPP1R9A CLTC CAPZB PRKN AR NXF1	1.66e-04	398	79	8	int:MYO6
Interaction	SON interactions	CLTC PRKN PRPF6 AR EP300 NXF1	1.67e-04	208	79	6	int:SON
Interaction	CDC42 interactions	FAT4 ABCB7 PTPN14 IGF2R PIK3R2 PPP1R9A CLTC CAPZB SLITRK5 PRKN FAM135A PREX1 NDUFS1 PREX2 ADD3	1.68e-04	1323	79	15	int:CDC42
Interaction	RHOJ interactions	ABCB7 PTPN14 IGF2R PIK3R2 PPP1R9A CLTC SLITRK5 FAM135A NDUFS1 ADD3	1.78e-04	633	79	10	int:RHOJ
Interaction	SNX1 interactions	DNAJC13 GTF2I SASH1 PRKN EP300 NXF1	1.85e-04	212	79	6	int:SNX1
Interaction	PRDX4 interactions	ENDOD1 CLTC PRKN AR EP300 NXF1	1.95e-04	214	79	6	int:PRDX4
Interaction	DFFA interactions	GTF2I PRKN USP15 NXF1	2.15e-04	75	79	4	int:DFFA
Interaction	TMED4 interactions	NID2 NAGLU PRKN NXF1	2.38e-04	77	79	4	int:TMED4
Interaction	WWTR1 interactions	PTPN14 GTF2I CLTC CAPZB USP15 EP300 CNN3 ADD3	2.46e-04	422	79	8	int:WWTR1
Interaction	HERC1 interactions	BRCA2 CLTC PRKN USP15 EP300	2.56e-04	144	79	5	int:HERC1
Interaction	PPP2R1A interactions	TRADD ABI1 PTPN14 FAM13A CLTC SERTAD4 CAPZB PRKN USP15 EP300	2.65e-04	665	79	10	int:PPP2R1A
Interaction	CRKL interactions	EPHB6 SASH1 PIK3R2 CAPZB PRKN NXF1	2.68e-04	227	79	6	int:CRKL
Interaction	ACTB interactions	ABI1 PIK3R2 SH3BGRL PPP1R9A CAPZB PRKN PSTPIP1 USP15 AR NDUFS1 EP300 CNN3 ADD3	2.81e-04	1083	79	13	int:ACTB
Interaction	ARPC4-TTLL3 interactions	CAPZB PRKN NXF1	2.91e-04	33	79	3	int:ARPC4-TTLL3
Interaction	ETV5 interactions	AR EP300 NXF1	2.91e-04	33	79	3	int:ETV5
Interaction	MIOS interactions	SESN3 PRKN SESN2 SESN1	3.18e-04	83	79	4	int:MIOS
Interaction	LGALS1 interactions	SLC12A6 NID2 FAT4 GTF2I IGF2R NAGLU PRKN	3.25e-04	332	79	7	int:LGALS1
Interaction	TES interactions	SH3BGRL CLTC CAPZB PRKN EP300 CNN3 NXF1	3.25e-04	332	79	7	int:TES
Interaction	RAB2A interactions	SLC12A6 ABCB7 IGF2R PIK3R2 PPP1R9A C3AR1 FAM135A EP300 ADD3	3.70e-04	567	79	9	int:RAB2A
Interaction	HPS6 interactions	PRKN AR EP300	3.77e-04	36	79	3	int:HPS6
Interaction	PPP1CA interactions	PPP1R9A CLTC CAPZB PYGM PRKN PRPF6 PREX1 AR EP300 ASF1A	3.80e-04	696	79	10	int:PPP1CA
Interaction	MEF2D interactions	AR EP300 ASF1A NXF1	3.80e-04	87	79	4	int:MEF2D
Interaction	SEPTIN8 interactions	EPHB6 PRKN EP300 SEPTIN12	3.80e-04	87	79	4	int:SEPTIN8
Interaction	DDX19A interactions	SH3BGRL PRKN AR NXF1	3.97e-04	88	79	4	int:DDX19A
Interaction	SEPTIN6 interactions	PRKN USP15 EP300 SEPTIN12	3.97e-04	88	79	4	int:SEPTIN6
Interaction	C1QTNF9 interactions	C1QL1 C1QL4 NDUFS1	4.09e-04	37	79	3	int:C1QTNF9
Interaction	RND1 interactions	IGF2R PIK3R2 CLTC SLITRK5 FAM135A ADD3	4.11e-04	246	79	6	int:RND1
Interaction	GLUL interactions	PRKN USP15 FAM135A AR EP300	4.16e-04	160	79	5	int:GLUL
Interaction	EEA1 interactions	IGF2R CAPZB PRKN FAM135A EP300	4.40e-04	162	79	5	int:EEA1
Cytoband	17q21	C1QL1 NAGLU AOC3	1.95e-04	63	81	3	17q21
Cytoband	Xq13.3	ABCB7 SH3BGRL	5.72e-04	20	81	2	Xq13.3
Cytoband	12q23.3	SLC41A2 HCFC2	1.76e-03	35	81	2	12q23.3
Cytoband	11q21	ENDOD1 SESN3	2.77e-03	44	81	2	11q21
GeneFamily	Sterile alpha motif domain containing	EPHB6 SAMD9 SASH1 PPP1R9A	1.02e-04	88	50	4	760
GeneFamily	Endogenous ligands\|C1q and TNF related	C1QL1 C1QL4	1.11e-03	18	50	2	1372
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	DNAJC13 SEC63	8.11e-03	49	50	2	584
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	PTPN14 MYO15A	8.44e-03	50	50	2	1293
GeneFamily	PDZ domain containing	PPP1R9A PREX1 PREX2	8.55e-03	152	50	3	1220
Coexpression	MASSARWEH_TAMOXIFEN_RESISTANCE_UP	SLC41A2 PTPN14 ELL2 SASH1 FAM13A SH3BGRL CDH3 PREX1 AR PRTFDC1	1.12e-05	583	80	10	M17454
Coexpression	GSE41176_UNSTIM_VS_ANTI_IGM_STIM_BCELL_3H_DN	DNAJC13 FAM13A SH3BGRL PARP8 SESN1 TPCN1	3.16e-05	197	80	6	M9916
Coexpression	GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_DN	MGAM ELL2 IGF2R HLA-DRB4 C3AR1 ACKR4	3.25e-05	198	80	6	M5776
Coexpression	RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN	MXRA5 ELL2 FBN1 SASH1 FAM13A PARP8 TSHZ1 SEC63 SESN1 ADD3 TPCN1	3.33e-05	807	80	11	M16651
Coexpression	GSE2585_THYMIC_DC_VS_MTEC_UP	MGAM TRADD BRCA2 PPP1R9A TENM1 PSTPIP1	3.35e-05	199	80	6	M6289
Coexpression	GSE360_CTRL_VS_L_DONOVANI_MAC_DN	C1QL1 SH3BGRL PYGM AR NXF1 ADD3	3.35e-05	199	80	6	M5159
Coexpression	GSE43955_1H_VS_20H_ACT_CD4_TCELL_WITH_TGFB_IL6_DN	ELL2 FBN1 SASH1 AOC3 C3AR1 CNN3	3.44e-05	200	80	6	M9677
Coexpression	GSE45739_UNSTIM_VS_ACD3_ACD28_STIM_WT_CD4_TCELL_UP	MSRA EPHB6 SASH1 FAM13A ADD3 TPCN1	3.44e-05	200	80	6	M9886
Coexpression	GSE7852_THYMUS_VS_FAT_TREG_DN	SLC41A2 NID2 ELL2 CLTC TSHZ1 FAM135A	3.44e-05	200	80	6	M5744
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4\|TCGA-Pancreas / Sample_Type by Project: Shred V9	FAT4 SASH1 CSRNP3 SEC63 AR PREX2	1.01e-06	184	80	6	67164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Pygm_C1ql1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	C1QL1 FBN1 SH3BGRL TENM1 PYGM	1.31e-05	168	80	5	f3879a8e11eaf866f37c52e67021be43f0b8784a
ToppCell	lymphoid-T_cell-pro-T_cell\|World / Lineage, cell class and subclass	ZSWIM8 TENM1 PYGM MYO15A	1.32e-05	80	80	4	9bd3ad5029eb84efcdbf08fe268c29fa9b0b302b
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NID2 FBN1 CSRNP3 AOC3 SERTAD4	1.83e-05	180	80	5	39ae8586efd91536e9ac6408d26de7e6d6237c41
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAM FAT4 TENM4 TENM1 MYO15A	2.03e-05	184	80	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAM FAT4 TENM4 TENM1 MYO15A	2.03e-05	184	80	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAM FAT4 TENM4 TENM1 MYO15A	2.03e-05	184	80	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MSRA SLC12A6 MGAM TENM1 TPCN1	2.20e-05	187	80	5	dcf6475ece5b34d9d58a0d1f51c18acedb19c119
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MSRA SLC12A6 MGAM TENM1 TPCN1	2.20e-05	187	80	5	f1356273bd3587b6883295edf15cb9cdb706c057
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN14 TENM4 SASH1 CDH3 FAM135A	2.37e-05	190	80	5	bf4511395fa97efd1c1cd17cc9bebb0271ee7f0e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN14 TENM4 SASH1 CDH3 FAM135A	2.37e-05	190	80	5	b6b8964b4910083499681b5fdf554e127b6a4c4e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN14 TENM4 SASH1 CDH3 FAM135A	2.43e-05	191	80	5	2fa1b9e76a0ed2d2f0de74349e266cf4a5f51aad
ToppCell	PND01-03-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	FBN1 IGF2R SH3BGRL SERTAD4 PREX2	2.43e-05	191	80	5	e7c605b56934d1383237c1f946dbccef25d91368
ToppCell	ASK454-Mesenchymal\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	MXRA5 FBN1 AOC3 TENM1 PRTFDC1	2.43e-05	191	80	5	e30ae7a12439f8a79820b13f03e822c1223fd0cb
ToppCell	ASK454-Mesenchymal-Fibroblast\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	MXRA5 FBN1 AOC3 TENM1 PRTFDC1	2.43e-05	191	80	5	1726add3f392a061536b7aff72ba84303f4a0b1f
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Artery\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FAT4 FBN1 ACKR4 FAM135A PREX2	2.43e-05	191	80	5	4b3d5157344dbfbf4fab518611cd9fa37fac7bd9
ToppCell	COVID-19-kidney-Myeloid\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SLC12A6 MGAM C3AR1 USP15 PREX1	2.49e-05	192	80	5	0b9d22a222f1201e375f8e55cace9ef939febae4
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	NID2 SLITRK5 SESN3 AR PREX2	2.68e-05	195	80	5	70387a62f121f8c374dba1aca9ab65cfed6a0b10
ToppCell	facs-Bladder-nan-3m\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGF2R SH3BGRL CLTC TSHZ1 ADD3	2.75e-05	196	80	5	44f5b1b474399c9316729155f2ea95a82ca66e30
ToppCell	facs-Bladder-nan-3m-Epithelial\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGF2R SH3BGRL CLTC TSHZ1 ADD3	2.75e-05	196	80	5	c0e90d964baa2eb4fbd18a52379ccec5d3bf59a8
ToppCell	Fibroblasts-DKK3+_Fibroblasts\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	MXRA5 PTPN14 FBN1 SERTAD4 CNN3	2.89e-05	198	80	5	4f4632f26a2043c5e4ab89031b4229b5dca1bd48
ToppCell	Sigmoid-T_cell-Treg\|T_cell / Region, Cell class and subclass	EPHB6 SESN3 USP15 AR ADD3	2.89e-05	198	80	5	e2d2f9f209f77d0c48cfe3e9902c0ae0795511b2
ToppCell	Bronchial_Biopsy\|World / Tissue, Lineage and Cell class of Lung Cells from 10X	EPHB6 PTPN14 SERTAD4 SESN3 CDH3	2.89e-05	198	80	5	f5b7013045b61fc56894f80092f799770dde1c8f
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NID2 MXRA5 FBN1 CNN3 ADD3	2.89e-05	198	80	5	d9ffc6589ed510ffa60c591f2a0fe123210f1455
ToppCell	Bronchial-10x5prime-Stromal-Fibroblastic-Fibro_myofibroblast\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	NID2 FAT4 MXRA5 FBN1 PRTFDC1	2.96e-05	199	80	5	21335475bbfbad8a6943b8076a6c1c67f3eec5d3
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	FAT4 PPP1R9A FAM135A PREX2 ADD3	3.03e-05	200	80	5	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	10x3'2.3-week_12-13-Mesenchymal_fibro-stroma-arteriolar_fibroblast\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	FAT4 MXRA5 FBN1 CSRNP3 CNN3	3.03e-05	200	80	5	fee22a6a6c7b93af204b5b56f2c34f1411500e18
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Gen_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	FAT4 PPP1R9A FAM135A PREX2 ADD3	3.03e-05	200	80	5	a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	FAT4 SAMD9 IGF2R PARP8 ADD3	3.03e-05	200	80	5	2281debd86e5d92e8fe0397aec9ef670800f7471
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	FAT4 SASH1 PPP1R9A PREX2 ADD3	3.03e-05	200	80	5	b2d4e6f3e8e4da62e6b02758ab2ed8f505269f9a
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FAT4 MXRA5 FBN1 TENM4 TENM1	3.03e-05	200	80	5	fb53be20392a8309a7393774c774a1b1aec6e676
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FAT4 MXRA5 FBN1 TENM1 PREX2	3.03e-05	200	80	5	58b38f9a484ee94191091a0659ed62ebed2d4a14
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	TENM1 SESN3 PRKN MYO15A	1.18e-04	140	80	4	7b359bfbd404ab06d799048252f4985d85852048
ToppCell	ileum-BEST4+_Enterocytes\|ileum / shred on tissue and cell subclass	NID2 ELL2 SAMD9 FAM13A	1.71e-04	154	80	4	608e9c982125e0c2c15b86b1920813845a0db81f
ToppCell	Children_(3_yrs)-Epithelial-basal_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PTPN14 SLITRK5 CDH3 AR	1.88e-04	158	80	4	d78e7e52657dc094430291fec07e9c298be9e584
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SASH1 C3AR1 MYO15A CDH3	1.97e-04	160	80	4	0544bc465af208da448858d6e174ff56f2e08a46
ToppCell	(0)_Myeloid-(00)_Monocyte-(000)_CD14+_Monocyte\|(00)_Monocyte / immune cells in Peripheral Blood (logTPM normalization)	GTF2I PARP8 PSTPIP1 TPCN1	2.32e-04	167	80	4	7d9fd6a7a45c2aa0d5f2e3960ca4c97ee8836ba5
ToppCell	Tuft-tuft-1\|World / Class top	SLC41A2 PPP1R9A ACKR4 CNN3	2.38e-04	168	80	4	8ddc2ec483ed2c6c0fb2ae521c6861ceb6d32e34
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_1_(HAND1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SERTAD4 PSTPIP1 CDH3 CNN3	2.43e-04	169	80	4	3f738fc56bbc70dc77c9ba41025631f8264cd2b3
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MSRA SLC12A6 TENM1 TPCN1	2.54e-04	171	80	4	f5014e3c387fe3118944af392abe10d6b9b0abab
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_T-T4_reg-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	TRADD PTPN14 SAMD9 SESN3	2.60e-04	172	80	4	9497948bbe53fb88c6ff6b347f743d456da587e5
ToppCell	5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NID2 PTPN14 SASH1 PREX2	2.66e-04	173	80	4	7dc988fc0ba29990567bf1bcdeb3faeeee507eb1
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-I_cells_(CCK+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MGAM ELL2 HABP2 SEPTIN12	2.78e-04	175	80	4	c031da47ca63d1133e13530cbf779df9435e22cb
ToppCell	TCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Non-keratinizing_Cervical_Squamous_Cell_Carcinoma-3\|TCGA-Cervix / Sample_Type by Project: Shred V9	SLC12A6 ABI1 SAMD9 FAM135A	2.78e-04	175	80	4	0cc215109d9915af47e4d0a120ce2e46910715fa
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SAMD9 PARP8 PSTPIP1 PREX1	2.78e-04	175	80	4	2f43883d7c89f09b0579a390a7431f1f9b832582
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SAMD9 PARP8 PSTPIP1 PREX1	2.78e-04	175	80	4	da92eb8af0c7c65fed4a1d960708240f35dd997d
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Dedifferentiated_Liposarcoma-4\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	FBN1 SASH1 SESN1 ADD3	2.78e-04	175	80	4	16849ea8f0985108baa2085f34c3de14a4f9f28b
ToppCell	5'-Adult-Appendix-Mesenchymal-myocytic-myofibroblast\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MXRA5 AOC3 TENM1 PRKN	2.90e-04	177	80	4	e65c0568dc5852108e9802273499bc7cf88fafab
ToppCell	nucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PTPN14 SLITRK5 CDH3 AR	2.90e-04	177	80	4	cbad1a23851151dbef01ea2af960e6f0944f838b
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TENM4 PYGM ACKR4 ADD3	2.90e-04	177	80	4	7af1a19692f7fe8f691178a4e57d62bc379e3d56
ToppCell	nucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Basal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PTPN14 SLITRK5 CDH3 AR	2.90e-04	177	80	4	ce86dfaeb74d995a19aea62f0fb15c4c0bb854b0
ToppCell	Children_(3_yrs)-Epithelial-basal_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PTPN14 SLITRK5 CDH3 AR	2.96e-04	178	80	4	fba2e38c05cbf031e0c6d47b1602575fea734a57
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	C1QL1 MXRA5 FBN1 ACKR4	3.09e-04	180	80	4	935c091bbcd6d10b81dc4731779e5bd98205c99f
ToppCell	5'-Airway_Nasal-Mesenchymal\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	C1QL1 MXRA5 FBN1 ACKR4	3.09e-04	180	80	4	3dd384b7f3d9582b8fec9fe05100e466e6218b76
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Adenocarcinoma_Mixed_Subtype\|TCGA-Lung / Sample_Type by Project: Shred V9	SLC41A2 FAM13A PPP1R9A TPCN1	3.16e-04	181	80	4	c783c2ecca7ab8e07646fa92dc7d436d24939d03
ToppCell	E18.5-samps-Mesenchymal-Matrix_fibroblast\|E18.5-samps / Age Group, Lineage, Cell class and subclass	FAT4 IGF2R SH3BGRL PREX2	3.22e-04	182	80	4	ceb37c214662a48efb56ab0d015977c6fab478b0
ToppCell	P28-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FBN1 FAM13A SH3BGRL PREX2	3.22e-04	182	80	4	19c5e3a9d9b3728303b682102e276adfe93aa759
ToppCell	wk_20-22-Mesenchymal-Chondrocyte-Resting_chondrocyte\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	MXRA5 TENM4 SERTAD4 AR	3.22e-04	182	80	4	03a5a02acd48f0eb210485348bfe0cd21f486215
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	NID2 FBN1 TENM4 PREX2	3.22e-04	182	80	4	fbd5e332df73bf7141c822fa67b76367dc962017
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MSRA SLC12A6 TENM1 TPCN1	3.29e-04	183	80	4	facd6dbe0851b537d70a899ac7485714ab27d071
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MSRA SLC12A6 TENM1 TPCN1	3.29e-04	183	80	4	84b64cf728629c3af9a8d2ed15b93adf562c54b8
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	C1QL1 MXRA5 FBN1 ACKR4	3.29e-04	183	80	4	803376f5260de83c48d4f7301278d078a32b3e6e
ToppCell	Control-APC-like-Dendritic_cells\|Control / group, cell type (main and fine annotations)	SLC41A2 MGAM TENM4 PREX1	3.29e-04	183	80	4	8f9c8e2436f18ea7c265b08e4e149e19cb513a16
ToppCell	Control-APC-like\|Control / group, cell type (main and fine annotations)	SLC41A2 MGAM TENM4 PREX1	3.29e-04	183	80	4	c313ac72cc9fa1583456d452393f61f0a4ca33a8
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	C1QL1 MXRA5 FBN1 ACKR4	3.29e-04	183	80	4	6d98973098c6d20c5305bce6a83a549a7d8dbfba
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	C1QL1 MXRA5 FBN1 ACKR4	3.29e-04	183	80	4	cc7f5a17b40e8d901885174922e5fa8877643071
ToppCell	Mesenchymal_cells-Osteoblasts\|Mesenchymal_cells / Lineage and Cell class	ELL2 CSRNP3 HAPLN4 PREX1	3.29e-04	183	80	4	d6b52d52fe9a7a6c798947f05420d79fe12e4662
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	FAM13A TENM1 SESN3 ACVR1C	3.29e-04	183	80	4	f2ef110bf29b1a8276ef216238363e542db262c1
ToppCell	droplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FAT4 PTPN14 FBN1 PREX2	3.29e-04	183	80	4	351d575339038bd4a66f408da518c567444208e8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MSRA SLC12A6 MGAM TENM4	3.36e-04	184	80	4	9434731f651820b05335085582960f08fbf895de
ToppCell	COVID-CD4-naive_CD4\|COVID / Condition, Cell_class and T cell subcluster	TRADD TENM1 SESN3 ADD3	3.36e-04	184	80	4	00db55970d336a301035efe43a4ab4db62627f38
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_T-CD4-positive,_alpha-beta_T_cell-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	TRADD SAMD9 FAM13A ADD3	3.43e-04	185	80	4	406b52516b26e9fe2c9e768950af447ec7ad5f3e
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	MXRA5 FBN1 TENM4 SERTAD4	3.43e-04	185	80	4	7dcdc009c5681ee05dd18968f7e85c3403fe34af
ToppCell	droplet-Liver-Hepatocytes-21m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 PTPN14 ACKR4 ADD3	3.43e-04	185	80	4	efcfbf5a48b3ea9a425183e5c2eec6a9585415a0
ToppCell	droplet-Liver-Hepatocytes-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 PTPN14 ACKR4 ADD3	3.43e-04	185	80	4	642088ace9230d38b0579853c54ff4dd8b5d5df4
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_T-CD4-positive,_alpha-beta_T_cell\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	TRADD SAMD9 FAM13A ADD3	3.43e-04	185	80	4	f2ebd099c8dfcfaca4298bcdd618c50701a9c2c8
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FBN1 TENM4 SERTAD4 SESN3	3.43e-04	185	80	4	1ac6a32cc56d5d819649bdd99518e2ead0eead4c
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NID2 ABCB7 FAM135A NXF1	3.50e-04	186	80	4	39e475a3c167b33daa63b0c1bfa32451c5f46635
ToppCell	(0)_MSCs\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	FBN1 FAM13A ACKR4 AR	3.50e-04	186	80	4	a832c1e0035bcd559722eccf262c145deb3494c7
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	MXRA5 FBN1 TENM4 SERTAD4	3.50e-04	186	80	4	4d68ee3d32f7ef884faf402ef92b31b0eb4656f1
ToppCell	TCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma-2\|TCGA-Kidney / Sample_Type by Project: Shred V9	NID2 FBN1 AOC3 PREX2	3.50e-04	186	80	4	1e6526fc9e9381b7ace864588cc7bd80194338d6
ToppCell	(0)_MSCs-(00)_Lepr-MSC\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	FBN1 FAM13A ACKR4 AR	3.50e-04	186	80	4	f0d156167d7cc2cd8a76e5a364233e9f2170bc01
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NID2 PTPN14 SASH1 TENM1	3.50e-04	186	80	4	f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NID2 ABCB7 FAM135A NXF1	3.50e-04	186	80	4	02418c50fdcca549bf73dedf6199ab4a27862a9b
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	C1QL1 SASH1 TENM1 AR	3.50e-04	186	80	4	6379609b7ace80683f5754b16aa77f11b43766ae
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	MXRA5 FBN1 TENM4 SERTAD4	3.57e-04	187	80	4	5258674d0346e5c51a4b965efcdc1790c970845d
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_3\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ABCB7 IGF2R SASH1 CNN3	3.57e-04	187	80	4	689b3cc76f1e04bd35a7d3ce19e9f08744a7835b
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NID2 PTPN14 SASH1 TENM1	3.57e-04	187	80	4	c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_Carcinoma-6\|TCGA-Breast / Sample_Type by Project: Shred V9	NID2 MXRA5 FBN1 TENM4	3.57e-04	187	80	4	a96495803ba13fcfadd1d83b3cf5774f3fed0a20
ToppCell	VE-Treg-CD4_Treg\|VE / Condition, Cell_class and T cell subcluster	SAMD9 FAM13A SESN3 USP15	3.64e-04	188	80	4	fa88ceb336e30de3585e62608527a0d44df74190
ToppCell	droplet-Lung-1m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PTPN14 GNAT1 ACKR4 TPCN1	3.64e-04	188	80	4	dc52dd2957be3f40001f0a56f3d9ac9d66ea466e
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NID2 FBN1 AOC3 SERTAD4	3.64e-04	188	80	4	6c6486cae9a8f2f8200598cb4bfd3fd513eb28a3
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 ACKR4 PREX2 ADD3	3.64e-04	188	80	4	0aa8747c2931b0c91f6d78bb2db8fd8ede6dd559
ToppCell	facs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FBN1 BBS2 ACKR4 ADD3	3.64e-04	188	80	4	aa516273cdde53c8c0295f06830972388f890c97
ToppCell	VE-Treg\|VE / Condition, Cell_class and T cell subcluster	SAMD9 FAM13A SESN3 USP15	3.64e-04	188	80	4	ef048517dfe2fc995d13eb1f08106a487354a4cc
ToppCell	droplet-Lung-1m-Endothelial-lymphatic_endothelial\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PTPN14 GNAT1 ACKR4 TPCN1	3.64e-04	188	80	4	2ef08313087e91985bcffc46c3798470cdeec49c
ToppCell	droplet-Lung-1m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PTPN14 GNAT1 ACKR4 TPCN1	3.64e-04	188	80	4	1f1604b6dc0a8ad0be3d9aac0bef448459c22465
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SASH1 PREX1 PREX2 CNN3	3.72e-04	189	80	4	b6b4da51bc7f2c13a2f940540fdc61027d084835
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Artery\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FBN1 ACKR4 FAM135A PREX2	3.72e-04	189	80	4	c45734970036e6d28d5e3fe7c9458fae38a3f624
ToppCell	droplet-Pancreas-Exocrine-24m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 PYGM ACKR4 AR	3.79e-04	190	80	4	8cb950effc449ae59a915132ecc079be54d1acfe
Disease	Carcinoma of lung	MXRA5 BRCA2 PRKN	3.03e-05	23	78	3	C0684249
Disease	Neoplasm of the genitourinary tract	BRCA2 PRKN AR	3.46e-05	24	78	3	cv:C0042065
Disease	1,5 anhydroglucitol measurement	MGAM PCDHA5 MGAM2	6.18e-05	29	78	3	EFO_0008009
Disease	fear of minor pain measurement	NAGLU TENM1 PRKN	7.57e-05	31	78	3	EFO_0008340
Disease	Prostatic Neoplasms	SAMD9 IGF2R BRCA2 PIK3R2 NAGLU SESN3 AR CNN3	2.24e-04	616	78	8	C0033578
Disease	Malignant neoplasm of prostate	SAMD9 IGF2R BRCA2 PIK3R2 NAGLU SESN3 AR CNN3	2.24e-04	616	78	8	C0376358
Disease	Malignant tumor of prostate	BRCA2 AR	2.45e-04	9	78	2	cv:C0376358
Disease	polyp of colon	NID2 CDH3 PREX1	4.45e-04	56	78	3	MONDO_0021400
Disease	PARKINSON DISEASE, LATE-ONSET	DNAJC13 PRKN	4.48e-04	12	78	2	C3160718
Disease	Benign tumor of pancreas	BRCA2 EP300	5.28e-04	13	78	2	C0347284
Disease	aortic measurement	ELL2 FBN1 SASH1 USP15 PREX1	5.45e-04	251	78	5	EFO_0020865
Disease	cutaneous melanoma, hair color	PTPN14 CDH3 ADD3	6.01e-04	62	78	3	EFO_0000389, EFO_0003924
Disease	nephroblastoma (is_implicated_in)	IGF2R BRCA2	6.15e-04	14	78	2	DOID:2154 (is_implicated_in)
Disease	birth weight	PTPN14 TENM4 ACVR1C PREX1 SESN1 PRTFDC1	6.66e-04	399	78	6	EFO_0004344
Disease	prostate cancer (is_marker_for)	PIK3R2 PREX1 AR EP300	7.91e-04	156	78	4	DOID:10283 (is_marker_for)
Disease	Pancreatic carcinoma	BRCA2 EP300	1.15e-03	19	78	2	C0235974
Disease	Adenocarcinoma of prostate	BRCA2 AR	1.27e-03	20	78	2	C0007112
Disease	Disorder of eye	BBS2 PRPF6 GNAT1 CDH3	2.44e-03	212	78	4	C0015397
Disease	Colorectal Carcinoma	EPHB6 CSRNP3 PARP8 TENM1 SESN2 EP300 PREX2	2.57e-03	702	78	7	C0009402

Protein segments in the cluster

Peptide	Gene	Start	Entry
EGDMYESANNRAEYY	EP300	616	Q09472
RQNYKDDFNAEYDEY	ELL2	541	O00472
AYYDYQGSLEEQEER	ADD3	261	Q9UEY8
RASAIAQDADQNYDY	C1QL4	181	Q86Z23
YYVNNEYTETELREN	ASF1A	111	Q9Y294
LLYNYDNQTGDRAEF	FAT4	4011	Q6V0I7
EYHEQGSLYDYLNRN	ACVR1C	271	Q8NER5
RASAIAQDADQNYDY	C1QL1	201	O75973
YEDEEAAVVQYNDPY	ABI1	421	Q8IZP0
DYFYAYDVDIQNSEG	FAM187A	131	A6NFU0
NNAFDQYRDLYFEGG	CAPZB	101	P47756
YESELPQGFQDYYNL	C3AR1	306	Q16581
RAQGQYMYDEQGAEY	PHYKPL	36	Q8IUZ5
SEAEADFYEQNSRYQ	NAGLU	631	P54802
YQGRYYDSLAQLEAQ	AOC3	266	Q16853
VGYALDYNEYFRDLN	PRTFDC1	196	Q9NRG1
REGQTFYYAEDYHQQ	MSRA	196	Q9UJ68
NQSTDYYYEENEMNG	ACKR4	6	Q9NPB9
AQEYRALYDYTAQNP	PSTPIP1	361	O43586
NDSEEFYYGGQVNYD	PARP8	131	Q8N3A8
VEYGRYSNELYELQA	HCFC2	91	Q9Y5Z7
RYGYQNDAEISSLYD	MGAM2	1206	Q2M2H8
FERASEYQLNDSAGY	GNAT1	136	P11488
GYENEDNYANIRFRF	MTMR8	256	Q96EF0
EAETYYYLNQGGNCE	MYO15A	1431	Q9UKN7
YGYQNDSEIASLYDE	MGAM	1251	O43451
RYGYQNDSEISSLYD	MGAM	2146	O43451
QFVDYARQAEEAYGA	CSRNP3	476	Q8WYN3
NTDYLDSDYQRGQLY	ENDOD1	131	O94919
DQQMVQNGYYEETDY	FAM135A	1091	Q9P2D6
LQQYYAIYDSGDRQG	NXF1	391	Q9UBU9
GALDEAAAYQSRDYY	AR	351	P10275
ELDYEDYNSYEINID	PCDHA5	306	Q9Y5H7
YAYGQSRQYLDDTEV	FAM13A	621	O94988
QYLVYNGDLVEYDAD	EXOC8	181	Q8IYI6
NVYGDDVEVDYRSYE	PIGK	111	Q92643
LESDYNEDNLDYYDV	NID2	306	Q14112
QQYQDKSREYDQLYE	PIK3R2	451	O00459
QYDYSYEDYNQEENT	HABP2	41	Q14520
YNNSDLFYREVADGA	BBS2	106	Q9BXC9
NTADYVGNYLYENNS	BRCA2	1706	P51587
YRNYYADNQTCDGEL	FBN1	1696	P35555
YNQEEYARYNSDLGE	HLA-DRB4	61	P13762
YDYRNIEGFVDLSDY	DNAJC13	151	O75165
NYGYRHNAEERYDAF	HAPLN4	251	Q86UW8
EESEDPDYYQYNIQA	GTF2I	241	P78347
YLNNSNYEEGDEYFD	SLC12A6	116	Q9UHW9
DEDDAIYTYNGVVAY	CDH3	241	P22223
QAEDEADYYYQLIDN	IGLV3-32	96	A0A0A0MS00
EYQEEDNSTYNFRWY	IGF2R	741	P11717
FGIRYDDYDYGEVNQ	SESN2	401	P58004
RYDDYDYGEINQLLD	SESN1	416	Q9Y6P5
QYNRYQQYGAEECVL	PRKN	311	O60260
SLAYEYEREGLYEQA	TRADD	251	Q15628
YDDIEGANYFQQANE	NDUFS1	656	P28331
EDLNDTNYDEFNGYA	PRPF6	71	O94906
NQDLLDNSYYEQYIL	SAMD9	401	Q5K651
GNILDYQLRYYDQAE	EPHB6	516	O15197
GDYNQFDSQDFLREY	PTPN14	151	Q15678
LGYRYNNNGEYEESS	PREX1	1346	Q8TCU6
NESQYRGDYDAFFEA	SH3BGRL	71	O75368
EEGLVNARFDYSYNN	TENM1	2031	Q9UKZ4
DYANYNYCDGRETSE	SLC41A2	111	Q96JW4
DYFETGYNERNNVNE	SERTAD4	316	Q9NUC0
FNNERYEAQRYDGFL	ABCB7	346	O75027
DELEELINYYQDRGY	CLTC	1281	Q00610
EYQDDYPRDYQYSDQ	CNN3	311	Q15417
KLDQRGYNAQEYYDR	PYGM	721	P11217
GLENLEYLQVDYNYI	SLITRK5	151	O94991
RYDDYDYGEVNQLLE	SESN3	416	P58005
GYINEQYEQYLQEEI	SEPTIN12	131	Q8IYM1
YKNYDYSEPGRNNEQ	USP15	271	Q9Y4E8
RYSYEYDADGQLQTV	TENM4	2191	Q6N022
LGNIDDLAQQYADYY	SASH1	56	O94885
TDREYQEYNPYEVLN	SEC63	96	Q9UGP8
EGYYYRDNVSVEEFQ	PREX2	1416	Q70Z35
GNDTYRINNKYDETY	PLAAT1	76	Q9HDD0
EEGYYYLNNFDNILN	TPCN1	621	Q9ULQ1
AVGEEDDDYQAYYLN	ZSWIM8	721	A7E2V4
DDDYQAYYLNAQDGA	ZSWIM8	726	A7E2V4
DAIDRYYYENSDQPI	TSHZ1	796	Q6ZSZ6
QYRQDADEEALYYTG	MXRA5	406	Q9NR99
VFNTYSNEDYDRRND	PPP1R9A	466	Q9ULJ8