Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phospholipase activity	PLCB2 PNPLA6 CHRM5 FAM83B	7.86e-05	114	40	4	GO:0004620
GeneOntologyMolecularFunction	lipase activity	PLCB2 PNPLA6 CHRM5 FAM83B	1.65e-04	138	40	4	GO:0016298
GeneOntologyMolecularFunction	ATP-dependent activity	HSP90B1 AK9 SETX POLQ DNAH14 DDX18 SMC6	1.94e-04	614	40	7	GO:0140657
GeneOntologyCellularComponent	cilium	ADCY10 CYLD FSIP2 ARL2 CCDC172 IFT88 CDKL1 DNAH14 CNGB3 CC2D2B	6.78e-06	898	41	10	GO:0005929
GeneOntologyCellularComponent	ciliary transition zone	IFT88 CDKL1 CC2D2B	5.37e-04	81	41	3	GO:0035869
GeneOntologyCellularComponent	sperm head-tail coupling apparatus	FSIP2 IFT88	5.63e-04	18	41	2	GO:0120212
GeneOntologyCellularComponent	motile cilium	ADCY10 FSIP2 CCDC172 IFT88 DNAH14	6.23e-04	355	41	5	GO:0031514
GeneOntologyCellularComponent	9+2 motile cilium	FSIP2 CCDC172 IFT88 DNAH14	1.19e-03	238	41	4	GO:0097729
GeneOntologyCellularComponent	90S preribosome	MPHOSPH10 SRFBP1	1.47e-03	29	41	2	GO:0030686
Domain	HEAT	NCAPG CAND1 SF3B1	1.59e-04	48	41	3	PF02985
Domain	-	ADCY10 ARL2 AK9 SETX POLQ DNAH14 DDX18 SMC6	1.85e-04	746	41	8	3.40.50.300
Domain	HEAT	NCAPG CAND1 SF3B1	2.79e-04	58	41	3	IPR000357
Domain	P-loop_NTPase	ADCY10 ARL2 AK9 SETX POLQ DNAH14 DDX18 SMC6	4.40e-04	848	41	8	IPR027417
Domain	HEAT_REPEAT	NCAPG CAND1 SF3B1	4.85e-04	70	41	3	PS50077
Domain	CNMP_BINDING_1	PNPLA6 CNGB3	2.24e-03	32	41	2	PS00888
Domain	CNMP_BINDING_2	PNPLA6 CNGB3	2.24e-03	32	41	2	PS00889
Domain	cNMP	PNPLA6 CNGB3	2.52e-03	34	41	2	SM00100
Domain	cNMP_binding	PNPLA6 CNGB3	2.52e-03	34	41	2	PF00027
Domain	cNMP-bd_dom	PNPLA6 CNGB3	2.67e-03	35	41	2	IPR000595
Domain	CNMP_BINDING_3	PNPLA6 CNGB3	2.67e-03	35	41	2	PS50042
Domain	ARM-like	NCAPG SETX CAND1 SF3B1	2.84e-03	270	41	4	IPR011989
Domain	C2	PLCB2 RIMS2 ITSN2	2.96e-03	131	41	3	PF00168
Domain	cNMP-bd-like	PNPLA6 CNGB3	3.14e-03	38	41	2	IPR018490
Domain	C2	PLCB2 RIMS2 ITSN2	3.36e-03	137	41	3	SM00239
Domain	C2	PLCB2 RIMS2 ITSN2	3.71e-03	142	41	3	PS50004
Domain	-	PLCB2 RIMS2 ITSN2	4.17e-03	148	41	3	2.60.40.150
Domain	-	PNPLA6 CNGB3	4.98e-03	48	41	2	2.60.120.10
Domain	C2_dom	PLCB2 RIMS2 ITSN2	5.55e-03	164	41	3	IPR000008
Domain	RmlC-like_jellyroll	PNPLA6 CNGB3	5.60e-03	51	41	2	IPR014710
Domain	ARM-type_fold	NCAPG CAND1 PPP2R5D SF3B1	6.36e-03	339	41	4	IPR016024
Domain	DEAD	POLQ DDX18	1.12e-02	73	41	2	PF00270
Domain	DEAD/DEAH_box_helicase_dom	POLQ DDX18	1.12e-02	73	41	2	IPR011545
Domain	-	NCAPG CAND1 SF3B1	1.27e-02	222	41	3	1.25.10.10
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	CYLD GCC1 ARL2 SETX CAND1 SF3B1 DDX18 FAM83B SMC6	3.05e-07	777	42	9	35844135
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	CYLD HSP90B1 ARL2 NCAPG PPP2R5D SF3B1 PNPLA6 DDX18 BAG5 FAM83B	8.33e-06	1487	42	10	33957083
Pubmed	Ovarian tumorB1-mediated heat shock transcription factor 1 deubiquitination is critical for glycolysis and development of endometriosis.	HSP90B1 SETX CAND1 BAG5 CC2D2B	9.56e-06	236	42	5	36339263
Pubmed	Identification of NPM-ALK interacting proteins by tandem mass spectrometry.	PLCB2 NCAPG SMC6	2.56e-05	47	42	3	14968112
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	HSP90B1 NCAPG SETX CAND1 SF3B1 PNPLA6 UBE4B MICAL2 DDX18	2.78e-05	1353	42	9	29467282
Pubmed	Functional role for senataxin, defective in ataxia oculomotor apraxia type 2, in transcriptional regulation.	SETX SF3B1	2.98e-05	7	42	2	19515850
Pubmed	Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A.	ARL2 PPP2R5D	3.97e-05	8	42	2	12912990
Pubmed	Modulation of gene expression in the preimplantation mouse embryo by TGF-alpha and TGF-beta.	HSP90B1 SF3B1	6.37e-05	10	42	2	7654366
Pubmed	In vitro nuclear interactome of the HIV-1 Tat protein.	NCAPG CAND1 SF3B1 DDX18	9.08e-05	195	42	4	19454010
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	HSP90B1 MPHOSPH10 CAND1 SF3B1 MICAL2 DDX18 BAG5 FAM83B	1.06e-04	1247	42	8	27684187
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	HSP90B1 NCAPG CAND1 SF3B1 DDX18 BAG5	1.11e-04	638	42	6	33239621
Pubmed	Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome.	CAND1 SF3B1	1.28e-04	14	42	2	18173839
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	CYLD HSP90B1 CAND1 SF3B1 IFT88 UBE4B MICAL2 DDX18	1.31e-04	1285	42	8	35914814
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	MPHOSPH10 SETX SF3B1 SRFBP1 CCDC174 DDX18 SMC6	1.33e-04	954	42	7	36373674
Pubmed	SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation.	RIMS2 ITSN2	1.48e-04	15	42	2	23999003
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	CYLD ANO5 CCDC172 GOLPH3L BAG5 CC2D2B	1.65e-04	686	42	6	29987050
Pubmed	Unpackaging the genetics of mammalian fertility: strategies to identify the "reproductive genome".	PRDM9 SETX	1.69e-04	16	42	2	29878059
Pubmed	Ciliary Hedgehog signaling patterns the digestive system to generate mechanical forces driving elongation.	ANO5 IFT88	2.15e-04	18	42	2	34893605
Pubmed	SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response.	HSP90B1 CAND1 SF3B1 DDX18 BAG5	2.32e-04	463	42	5	34901782
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	MPHOSPH10 SETX SF3B1 POLQ	2.35e-04	250	42	4	33536335
Pubmed	Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	CYLD CAND1 BAG5	2.44e-04	100	42	3	10048485
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	HSP90B1 MPHOSPH10 SF3B1 RIMS2 DDX18 SMC6	2.75e-04	754	42	6	35906200
Pubmed	The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.	HSP90B1 NCAPG SETX SMC6	2.81e-04	262	42	4	36880596
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	HSP90B1 MPHOSPH10 SF3B1 POLQ RIMS2 IFT88 CCDC191 ITSN2	2.87e-04	1442	42	8	35575683
Pubmed	BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.	GCC1 PPP2R5D ITSN2 FAM83B	3.87e-04	285	42	4	34369648
Pubmed	Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.	HSP90B1 ARL2 CAND1 SF3B1 BAG5	4.61e-04	538	42	5	28524877
Pubmed	SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.	HSP90B1 NCAPG CAND1 SF3B1 GOLPH3L DDX18	6.15e-04	878	42	6	37223481
Pubmed	BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.	SF3B1 DDX18	6.47e-04	31	42	2	23086144
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	HSP90B1 NCAPG SETX CAND1 SF3B1	6.58e-04	582	42	5	20467437
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	HSP90B1 NCAPG CAND1 SF3B1	7.83e-04	344	42	4	30333137
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	HSP90B1 ARL2 MPHOSPH10 NCAPG CAND1 SF3B1 DDX18	9.32e-04	1318	42	7	30463901
Pubmed	Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis.	HSP90B1 CAND1 FAM83B	9.44e-04	159	42	3	31332168
Pubmed	Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress.	MPHOSPH10 SF3B1 DDX18	9.44e-04	159	42	3	22751105
Pubmed	A protein interaction landscape of breast cancer.	CAND1 PNPLA6 MICAL2 BAG5 FAM83B	9.65e-04	634	42	5	34591612
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	ADCY10 HSP90B1 NCAPG CAND1 SF3B1 IFT88 BAG5	1.00e-03	1335	42	7	29229926
CoexpressionAtlas	dev gonad_e13.5_M_GermCell_Oct_top-relative-expression-ranked_1000	CCDC172 MPHOSPH10 NCAPG SETX SRFBP1 RIMS2 IFT88 UBE4B CCDC191 DDX18	2.36e-06	810	41	10	gudmap_dev gonad_e13.5_M_GermCell_Oct_1000
CoexpressionAtlas	dev gonad_e11.5_M_PrimGermCell_Oct_k-means-cluster#4_top-relative-expression-ranked_1000	MPHOSPH10 SETX SRFBP1 RIMS2 CCDC191 DDX18	2.95e-05	315	41	6	gudmap_dev gonad_e11.5_M_PrimGermCell_Oct_k4_1000
CoexpressionAtlas	dev gonad_e13.5_F_MeioticGermCell_Oct_top-relative-expression-ranked_500	CYLD PRDM9 CCDC172 NCAPG RIMS2 CCDC191	8.98e-05	385	41	6	gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_500
CoexpressionAtlas	dev gonad_e12.5_M_GermCellTestis_Oct_top-relative-expression-ranked_1000	CCDC172 MPHOSPH10 NCAPG SETX SRFBP1 RIMS2 CCDC191 DDX18	1.19e-04	795	41	8	gudmap_dev gonad_e12.5_M_GermCellTestis_Oct_1000
CoexpressionAtlas	dev gonad_e11.5_F_PrimGermCell_Oct_k-means-cluster#3_top-relative-expression-ranked_1000	NCAPG SETX SRFBP1 RIMS2 CCDC191 DDX18	2.45e-04	463	41	6	gudmap_dev gonad_e11.5_F_PrimGermCell_Oct_k3_1000
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Mesenchymal-Unfolded_protein_responsible_cell\|3m / Sample Type, Dataset, Time_group, and Cell type.	MPHOSPH10 GOLPH3L CCDC174 DDX18 BAG5	1.23e-06	200	42	5	e68e44ab57d17ac4845d9e3798814d048d79e888
Disease	S-6-hydroxywarfarin to S-warfarin ratio measurement	NPFFR2 PRDM9 DDX18	2.34e-04	88	40	3	EFO_0803332
Disease	alpha fetoprotein measurement	SETX POLQ SMC6	3.41e-04	100	40	3	EFO_0010583
Disease	Marijuana Abuse	GCC1 CHRM5	7.61e-04	30	40	2	C0024809
Disease	Alzheimer disease, polygenic risk score	FSIP2 GOLPH3L CDKL1 DNAH14 DDX18	1.13e-03	586	40	5	EFO_0030082, MONDO_0004975

Protein segments in the cluster

Peptide	Gene	Start	Entry
VVERIKREKLMTIKI	ANO5	861	Q75V66
ILKIEKVLKRMREIK	BAG5	276	Q9UL15
VQMLKDIKKEKVLLR	PPP2R5D	556	Q14738
FMKILKLIVKEERII	ADCY10	626	Q96PN6
LKKVRRLIMKRIVKI	CC2D2B	791	Q6DHV5
ITKKRELLMKENVKI	CCDC172	121	P0C7W6
VVSRKKQKIIKMLLI	NPFFR2	366	Q9Y5X5
KLKEIERKRLELMQK	ITSN2	671	Q9NZM3
ILKKMKQKERELRLL	ARL2	6	P36404
RKKLKMLNIAKKILR	PNPLA6	136	Q8IY17
VKIMEKVIKIIDELK	FSIP2	6316	Q5CZC0
ERKVVKMILKLLEDK	CAND1	46	Q86VP6
KETIRKMIKEARKVI	FAM83B	136	Q5T0W9
RMKIKEKEKRRKLLE	MPHOSPH10	586	O00566
LRKKDVKRAIRKVML	OR13H1	291	Q8NG92
MKLLRKKIEKRNLKL	DDX18	6	Q9NVP1
ERKIILAVMDRQKKK	RIMS2	36	Q9UQ26
RLKLELRKKETERKM	PRDM9	166	Q9NQV7
RKKLVRKTLDMIKKI	HSP90B1	461	P14625
VLKDKMEKLKRLLQV	GCC1	431	Q96CN9
RGLLRKLKEMKKKVE	IGSF22	216	Q8N9C0
RKLKRLEKMKEIREQ	IFT88	711	Q13099
KKIALREIRMLKQLK	CDKL1	46	Q00532
ELLILKRVLEMRKKA	POLQ	126	O75417
EKMVKERKRKLKEVL	CCDC191	301	Q8NCU4
MRKKRLLDRKVLLKS	GOLPH3L	96	Q9H4A5
TKEMILKKLIRRTKD	DNAH14	1901	Q0VDD8
ILEARLAKLRQKKMK	CCDC174	291	Q6PII3
ATKIMKLRKILEKVE	CYLD	656	Q9NQC7
LRRRKKLEKAMKQLV	MICAL2	1781	O94851
LERKKLIKDMKAKIR	AK9	1176	Q5TCS8
KLVMEIIKLIKDKRK	SETX	2321	Q7Z333
MTKRKRVVLVKERKA	CHRM5	426	P08912
VKKIRKQMKLLLLLL	B4GALNT4	6	Q76KP1
RKKELKMAEIKVKLI	NCAPG	486	Q9BPX3
RILMKKARVLLKQKA	CNGB3	636	Q9NQW8
VLMVVKCVRRKKEQK	SCN2B	176	O60939
MRKEVKRIRVLVIRK	SRFBP1	16	Q8NEF9
EQKERKIMKLLLKIK	SF3B1	491	O75533
EMLKRCKTQLKKLVR	UBE4B	811	O95155
KELKMKIRKNISEIR	SMC6	711	Q96SB8
KEMKKKLETKRLERI	PLCB2	1041	Q00722