Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionH3K27me3 modified histone binding

TAF1 TAF1L

2.18e-055302GO:0061628
GeneOntologyMolecularFunctionSH3 domain binding

NCF1C NCF1B CD2AP SH3KBP1

5.98e-05143304GO:0017124
GeneOntologyMolecularFunctionRNA polymerase I general transcription initiation factor activity

TAF1 TAF1L

7.80e-059302GO:0001181
GeneOntologyMolecularFunctionsuperoxide-generating NADPH oxidase activator activity

NCF1C NCF1B

9.75e-0510302GO:0016176
GeneOntologyMolecularFunctionsuperoxide-generating NAD(P)H oxidase activity

NCF1C NCF1B

1.43e-0412302GO:0016175
GeneOntologyMolecularFunctionmethylated histone binding

ZMYND11 TAF1 TAF1L

2.88e-0486303GO:0035064
GeneOntologyMolecularFunctionmethylation-dependent protein binding

ZMYND11 TAF1 TAF1L

3.08e-0488303GO:0140034
GeneOntologyMolecularFunctionoxidoreductase activity, acting on NAD(P)H, oxygen as acceptor

NCF1C NCF1B

4.08e-0420302GO:0050664
GeneOntologyMolecularFunctionRNA polymerase II core promoter sequence-specific DNA binding

TAF1 TAF1L

6.41e-0425302GO:0000979
GeneOntologyMolecularFunctionRNA polymerase II general transcription initiation factor binding

TAF1 TAF1L

7.48e-0427302GO:0001091
GeneOntologyMolecularFunctionlysine-acetylated histone binding

TAF1 TAF1L

9.25e-0430302GO:0070577
GeneOntologyMolecularFunctionacetylation-dependent protein binding

TAF1 TAF1L

9.88e-0431302GO:0140033
GeneOntologyMolecularFunctionTBP-class protein binding

TAF1 TAF1L

1.12e-0333302GO:0017025
GeneOntologyMolecularFunctionphosphatidylinositol binding

NCF1C NCF1B MYO10 ASAP1

1.22e-03316304GO:0035091
GeneOntologyMolecularFunctionphosphatidylinositol-3,4-bisphosphate binding

NCF1C NCF1B

1.26e-0335302GO:0043325
GeneOntologyMolecularFunctiontranscription regulator inhibitor activity

TAF1 TAF1L

1.33e-0336302GO:0140416
GeneOntologyMolecularFunctionubiquitin conjugating enzyme activity

TAF1 TAF1L

1.41e-0337302GO:0061631
GeneOntologyMolecularFunctiongamma-tubulin binding

DIXDC1 ARHGEF7

1.48e-0338302GO:0043015
GeneOntologyMolecularFunctionprotein domain specific binding

CARD10 DIXDC1 NCF1C NCF1B CD2AP SH3KBP1

1.67e-03875306GO:0019904
GeneOntologyMolecularFunctionubiquitin-like protein conjugating enzyme activity

TAF1 TAF1L

1.90e-0343302GO:0061650
GeneOntologyMolecularFunctionphosphatidylinositol-3,4,5-trisphosphate binding

MYO10 ASAP1

2.46e-0349302GO:0005547
GeneOntologyMolecularFunctionhistone acetyltransferase activity

TAF1 TAF1L

2.66e-0351302GO:0004402
GeneOntologyMolecularFunctionenzyme activator activity

ASAP2 NCF1C NCF1B PREX2 ASAP1

2.72e-03656305GO:0008047
GeneOntologyMolecularFunctionRNA polymerase II general transcription initiation factor activity

TAF1 TAF1L

2.76e-0352302GO:0016251
GeneOntologyMolecularFunctioncore promoter sequence-specific DNA binding

TAF1 TAF1L

3.08e-0355302GO:0001046
GeneOntologyMolecularFunctionpeptide-lysine-N-acetyltransferase activity

TAF1 TAF1L

3.08e-0355302GO:0061733
GeneOntologyMolecularFunctionlipid binding

C3 LIPC NCF1C NCF1B MYO10 ASAP1

3.09e-03988306GO:0008289
GeneOntologyMolecularFunctionmodification-dependent protein binding

ZMYND11 TAF1 TAF1L

3.58e-03206303GO:0140030
GeneOntologyMolecularFunctionpeptide N-acetyltransferase activity

TAF1 TAF1L

3.66e-0360302GO:0034212
GeneOntologyMolecularFunctiongeneral transcription initiation factor binding

TAF1 TAF1L

4.15e-0364302GO:0140296
GeneOntologyMolecularFunctionenzyme regulator activity

C3 ASAP2 NCF1C NCF1B ARHGEF7 PREX2 ASAP1

4.29e-031418307GO:0030234
GeneOntologyMolecularFunctionbasal RNA polymerase II transcription machinery binding

TAF1 TAF1L

4.41e-0366302GO:0001099
GeneOntologyMolecularFunctionbasal transcription machinery binding

TAF1 TAF1L

4.41e-0366302GO:0001098
GeneOntologyMolecularFunctiongeneral transcription initiation factor activity

TAF1 TAF1L

4.67e-0368302GO:0140223
GeneOntologyMolecularFunctionactin filament binding

PSTPIP1 MYO10 CD2AP

4.69e-03227303GO:0051015
GeneOntologyMolecularFunctionactin binding

DIXDC1 PSTPIP1 MYO10 CD2AP

5.47e-03479304GO:0003779
GeneOntologyMolecularFunctionp53 binding

TAF1 TAF1L

5.95e-0377302GO:0002039
GeneOntologyMolecularFunctionN-acetyltransferase activity

TAF1 TAF1L

6.10e-0378302GO:0008080
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

ASAP2 ARHGEF7 PREX2 ASAP1

6.67e-03507304GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

ASAP2 ARHGEF7 PREX2 ASAP1

6.67e-03507304GO:0030695
GeneOntologyMolecularFunctionpromoter-specific chromatin binding

TAF1 TAF1L

6.89e-0383302GO:1990841
GeneOntologyMolecularFunctionhistone binding

ZMYND11 TAF1 TAF1L

7.20e-03265303GO:0042393
GeneOntologyMolecularFunctionGTPase activator activity

ASAP2 PREX2 ASAP1

8.29e-03279303GO:0005096
GeneOntologyMolecularFunctionphospholipid binding

NCF1C NCF1B MYO10 ASAP1

8.73e-03548304GO:0005543
GeneOntologyMolecularFunctionoxidoreductase activity, acting on NAD(P)H

NCF1C NCF1B

8.93e-0395302GO:0016651
GeneOntologyMolecularFunctionN-acyltransferase activity

TAF1 TAF1L

1.02e-02102302GO:0016410
GeneOntologyMolecularFunctionacetyltransferase activity

TAF1 TAF1L

1.06e-02104302GO:0016407
GeneOntologyMolecularFunctionsulfur compound binding

LIPC TAF1 P2RX1

1.23e-02323303GO:1901681
GeneOntologyBiologicalProcessneutrophil-mediated killing of gram-positive bacterium

NCF1C NCF1B

2.04e-055302GO:0070946
GeneOntologyBiologicalProcessneutrophil-mediated killing of fungus

NCF1C NCF1B

4.28e-057302GO:0070947
GeneOntologyBiologicalProcessNADP catabolic process

NCF1C NCF1B

4.28e-057302GO:0006742
GeneOntologyBiologicalProcessregulation of respiratory burst involved in inflammatory response

NCF1C NCF1B

1.12e-0411302GO:0060264
GeneOntologyBiologicalProcessrespiratory burst involved in inflammatory response

NCF1C NCF1B

1.58e-0413302GO:0002536
GeneOntologyBiologicalProcessregulation of smooth muscle contraction

P2RX1 NCF1C NCF1B

2.04e-0479303GO:0006940
GeneOntologyBiologicalProcessneutrophil-mediated killing of bacterium

NCF1C NCF1B

2.42e-0416302GO:0070944
GeneOntologyBiologicalProcessresponse to yeast

NCF1C NCF1B

3.08e-0418302GO:0001878
GeneOntologyBiologicalProcessneutrophil-mediated killing of symbiont cell

NCF1C NCF1B

3.44e-0419302GO:0070943
GeneOntologyBiologicalProcessrespiratory burst involved in defense response

NCF1C NCF1B

3.82e-0420302GO:0002679
GeneOntologyBiologicalProcesspositive regulation of GTPase activity

ASAP2 ARHGEF7 PREX2 ASAP1

4.11e-04244304GO:0043547
GeneOntologyBiologicalProcessneutrophil mediated cytotoxicity

NCF1C NCF1B

4.22e-0421302GO:0070942
GeneOntologyBiologicalProcessnegative regulation of smooth muscle contraction

NCF1C NCF1B

4.64e-0422302GO:0045986
GeneOntologyBiologicalProcesshydrogen peroxide biosynthetic process

NCF1C NCF1B

4.64e-0422302GO:0050665
GeneOntologyBiologicalProcessregulation of respiratory burst

NCF1C NCF1B

5.08e-0423302GO:0060263
GeneOntologyBiologicalProcesspositive regulation of hydrolase activity

ASAP2 P2RX1 ARHGEF7 PREX2 ASAP1

7.02e-04499305GO:0051345
GeneOntologyCellularComponentactin cytoskeleton

ACTL7A DIXDC1 PSTPIP1 MYO10 CD2AP ASAP1

1.44e-04576306GO:0015629
GeneOntologyCellularComponentNADPH oxidase complex

NCF1C NCF1B

3.00e-0418302GO:0043020
GeneOntologyCellularComponentpronucleus

TAF1 TAF1L

7.35e-0428302GO:0045120
GeneOntologyCellularComponentMLL1 complex

TAF1 TAF1L

9.61e-0432302GO:0071339
GeneOntologyCellularComponentMLL1/2 complex

TAF1 TAF1L

1.02e-0333302GO:0044665
GeneOntologyCellularComponentsecretory granule membrane

ATP8A1 P2RX1 ANPEP CFAP65

1.20e-03329304GO:0030667
GeneOntologyCellularComponentsomatodendritic compartment

DIXDC1 NCF1C NCF1B ARHGEF7 MYO10 CD2AP ASAP1

1.46e-031228307GO:0036477
GeneOntologyCellularComponentpodosome

CD2AP ASAP1

1.58e-0341302GO:0002102
GeneOntologyCellularComponentcell cortex

PSTPIP1 ARHGEF7 MYO10 CD2AP

1.86e-03371304GO:0005938
GeneOntologyCellularComponenttranscription factor TFIID complex

TAF1 TAF1L

2.07e-0347302GO:0005669
GeneOntologyCellularComponentsecretory granule

ACTL7A C3 ATP8A1 P2RX1 ANPEP CFAP65

2.80e-031014306GO:0030141
GeneOntologyCellularComponentruffle

ARHGEF7 MYO10 CD2AP

3.15e-03206303GO:0001726
GeneOntologyCellularComponentGolgi apparatus subcompartment

ASAP2 ATP8A1 CD2AP ASAP1

3.52e-03443304GO:0098791
MousePhenoincreased angiotensin I-converting enzyme activity

NCF1C NCF1B

5.77e-056282MP:0003184
MousePhenoabnormal angiotensin I-converting enzyme activity

NCF1C NCF1B

5.77e-056282MP:0013254
MousePhenoliver abscess

NCF1C NCF1B

8.07e-057282MP:0003332
MousePhenoimpaired granulocyte bactericidal activity

NCF1C NCF1B

1.72e-0410282MP:0005074
DomainSH3_1

ASAP2 PSTPIP1 ARHGEF7 CD2AP ASAP1 SH3KBP1

1.34e-07164286PF00018
DomainSH3

ASAP2 PSTPIP1 ARHGEF7 CD2AP ASAP1 SH3KBP1

6.80e-07216286PS50002
DomainSH3

ASAP2 PSTPIP1 ARHGEF7 CD2AP ASAP1 SH3KBP1

6.80e-07216286SM00326
DomainSH3_domain

ASAP2 PSTPIP1 ARHGEF7 CD2AP ASAP1 SH3KBP1

7.57e-07220286IPR001452
DomainTAF_II_230-bd

TAF1 TAF1L

2.17e-062282IPR009067
DomainDUF3591

TAF1 TAF1L

2.17e-062282PF12157
DomainTFIID_sub1_DUF3591

TAF1 TAF1L

2.17e-062282IPR022591
Domain-

TAF1 TAF1L

2.17e-0622821.10.1100.10
DomainTBP-binding

TAF1 TAF1L

2.17e-062282PF09247
DomainTAF1_animal

TAF1 TAF1L

2.17e-062282IPR011177
DomainSH3_9

ASAP2 PSTPIP1 CD2AP SH3KBP1

5.34e-0678284PF14604
DomainPH

ASAP2 ARHGEF7 MYO10 PREX2 ASAP1

2.07e-05229285PF00169
DomainBromodomain

ZMYND11 TAF1 TAF1L

2.46e-0538283PF00439
DomainBROMODOMAIN_2

ZMYND11 TAF1 TAF1L

3.10e-0541283PS50014
DomainBROMO

ZMYND11 TAF1 TAF1L

3.33e-0542283SM00297
DomainBromodomain

ZMYND11 TAF1 TAF1L

3.33e-0542283IPR001487
Domain-

ZMYND11 TAF1 TAF1L

3.33e-05422831.20.920.10
DomainPH

ASAP2 ARHGEF7 MYO10 PREX2 ASAP1

5.23e-05278285SM00233
DomainPH_DOMAIN

ASAP2 ARHGEF7 MYO10 PREX2 ASAP1

5.32e-05279285PS50003
DomainPH_domain

ASAP2 ARHGEF7 MYO10 PREX2 ASAP1

5.41e-05280285IPR001849
Domain-

ASAP2 ARHGEF7 MYO10 PREX2 ASAP1

2.59e-043912852.30.29.30
DomainSH3_2

ARHGEF7 CD2AP SH3KBP1

2.84e-0486283IPR011511
DomainSH3_2

ARHGEF7 CD2AP SH3KBP1

2.84e-0486283PF07653
DomainPH_dom-like

ASAP2 ARHGEF7 MYO10 PREX2 ASAP1

3.84e-04426285IPR011993
DomainBromodomain_CS

TAF1 TAF1L

6.89e-0426282IPR018359
DomainArfGap

ASAP2 ASAP1

8.58e-0429282SM00105
DomainARFGAP

ASAP2 ASAP1

8.58e-0429282PS50115
DomainArfGAP

ASAP2 ASAP1

8.58e-0429282IPR001164
DomainArfGap

ASAP2 ASAP1

8.58e-0429282PF01412
Domain-

ASAP2 ASAP1

9.19e-04302821.20.1270.60
DomainAH/BAR-dom

ASAP2 ASAP1

9.19e-0430282IPR027267
DomainBROMODOMAIN_1

TAF1 TAF1L

1.40e-0337282PS00633
DomainGDS_CDC24_CS

ARHGEF7 PREX2

1.55e-0339282IPR001331
DomainAnk_2

ASAP2 HECTD1 ASAP1

3.99e-03215283PF12796
DomainDH_1

ARHGEF7 PREX2

4.00e-0363282PS00741
DomainCH

DIXDC1 ARHGEF7

4.25e-0365282SM00033
DomainRhoGEF

ARHGEF7 PREX2

4.64e-0368282SM00325
DomainAnk

ASAP2 HECTD1 ASAP1

4.70e-03228283PF00023
DomainDH_2

ARHGEF7 PREX2

4.91e-0370282PS50010
DomainRhoGEF

ARHGEF7 PREX2

4.91e-0370282PF00621
DomainCH

DIXDC1 ARHGEF7

4.91e-0370282PF00307
DomainDH-domain

ARHGEF7 PREX2

5.05e-0371282IPR000219
Domain-

ARHGEF7 PREX2

5.05e-03712821.20.900.10
Domain-

DIXDC1 ARHGEF7

5.05e-03712821.10.418.10
DomainCH

DIXDC1 ARHGEF7

5.33e-0373282PS50021
DomainCH-domain

DIXDC1 ARHGEF7

5.62e-0375282IPR001715
Domain-

ASAP2 HECTD1 ASAP1

5.93e-032482831.25.40.20
DomainANK

ASAP2 HECTD1 ASAP1

6.13e-03251283SM00248
DomainANK_REPEAT

ASAP2 HECTD1 ASAP1

6.27e-03253283PS50088
DomainAnkyrin_rpt-contain_dom

ASAP2 HECTD1 ASAP1

6.33e-03254283IPR020683
DomainANK_REP_REGION

ASAP2 HECTD1 ASAP1

6.33e-03254283PS50297
DomainAnkyrin_rpt

ASAP2 HECTD1 ASAP1

6.90e-03262283IPR002110
PathwayREACTOME_CROSS_PRESENTATION_OF_PARTICULATE_EXOGENOUS_ANTIGENS_PHAGOSOMES

NCF1C NCF1B

9.10e-059232MM14524
PathwayREACTOME_INNATE_IMMUNE_SYSTEM

C3 PSTPIP1 ATP8A1 P2RX1 ANPEP NCF1C NCF1B MYO10

1.13e-04995238MM14661
PathwayREACTOME_RAC1_GTPASE_CYCLE

NCF1C NCF1B ARHGEF7 PREX2

1.69e-04175234MM15599
PathwayBIOCARTA_ARAP_PATHWAY

ASAP2 ASAP1

3.41e-0417232M2482
PathwayWP_OXIDATIVE_STRESS_AND_REDOX_PATHWAY

ANPEP NCF1C NCF1B

4.33e-0492233MM15823
PathwayKEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS

ASAP2 MYO10 ASAP1

4.91e-0496233M16121
PathwayREACTOME_RHO_GTPASES_ACTIVATE_NADPH_OXIDASES

NCF1C NCF1B

7.47e-0425232MM15269
PathwayREACTOME_PURINERGIC_SIGNALING_IN_LEISHMANIASIS_INFECTION

C3 PSTPIP1

8.08e-0426232M29838
PathwayREACTOME_EGFR_DOWNREGULATION

ARHGEF7 SH3KBP1

1.15e-0331232MM14705
PathwayREACTOME_EGFR_DOWNREGULATION

ARHGEF7 SH3KBP1

1.15e-0331232M16597
PathwayBIOCARTA_FMLP_PATHWAY

NCF1C NCF1B

1.38e-0334232MM1399
PathwayKEGG_BASAL_TRANSCRIPTION_FACTORS

TAF1 TAF1L

1.47e-0335232M4864
PathwayREACTOME_DETOXIFICATION_OF_REACTIVE_OXYGEN_SPECIES

NCF1C NCF1B

1.47e-0335232MM14944
PathwayPID_RAC1_REG_PATHWAY

ARHGEF7 PREX2

1.73e-0338232M241
PathwayREACTOME_ROS_AND_RNS_PRODUCTION_IN_PHAGOCYTES

NCF1C NCF1B

1.73e-0338232MM14519
PathwayPID_ERBB1_INTERNALIZATION_PATHWAY

ARHGEF7 SH3KBP1

2.01e-0341232M214
PathwayWP_MICROGLIA_PATHOGEN_PHAGOCYTOSIS_PATHWAY

NCF1C NCF1B

2.52e-0346232MM15837
PathwayWP_MECP2_AND_ASSOCIATED_RETT_SYNDROME

TAF1 TAF1L

2.52e-0346232MM15949
PathwayREACTOME_HIV_TRANSCRIPTION_INITIATION

TAF1 TAF1L

2.63e-0347232M29568
PathwayREACTOME_RNA_POLYMERASE_II_PROMOTER_ESCAPE

TAF1 TAF1L

2.74e-0348232MM15424
PathwayREACTOME_SIGNALING_BY_EGFR

ARHGEF7 SH3KBP1

2.86e-0349232MM14695
PathwayKEGG_ENDOCYTOSIS

ASAP2 ASAP1 SH3KBP1

3.05e-03181233M1519
PathwayREACTOME_SIGNALING_BY_EGFR

ARHGEF7 SH3KBP1

3.34e-0353232M27039
Pubmed

CIN85, a Cbl-interacting protein, is a component of AMAP1-mediated breast cancer invasion machinery.

ASAP2 ASAP1 SH3KBP1

2.24e-08731317255943
Pubmed

Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities.

ASAP2 ASAP1 SH3KBP1

3.58e-08831315719014
Pubmed

Neutrophil-activating therapy for the treatment of cancer.

C3 NCF1C NCF1B

1.05e-071131336706760
Pubmed

Taf1 knockout is lethal in embryonic male mice and heterozygous females show weight and movement disorders.

TAF1 TAF1L

7.69e-07231238804708
Pubmed

CIN85 Deficiency Prevents Nephrin Endocytosis and Proteinuria in Diabetes.

CD2AP SH3KBP1

7.69e-07231227531950
Pubmed

Functional pseudogenes inhibit the superoxide production.

NCF1C NCF1B

7.69e-07231226086043
Pubmed

TAFII250, Egr-1, and D-type cyclin expression in mice and neonatal rat cardiomyocytes treated with doxorubicin.

TAF1 TAF1L

7.69e-07231210070062
Pubmed

Sustained expression of a neuron-specific isoform of the Taf1 gene in development stages and aging in mice.

TAF1 TAF1L

7.69e-07231222842574
Pubmed

CD2AP/CIN85 balance determines receptor tyrosine kinase signaling response in podocytes.

CD2AP SH3KBP1

7.69e-07231217213204
Pubmed

Frameshift Mutations in the Mononucleotide Repeats of TAF1 and TAF1L Genes in Gastric and Colorectal Cancers with Regional Heterogeneity.

TAF1 TAF1L

7.69e-07231227571988
Pubmed

Striatal Cholinergic Dysregulation after Neonatal Decrease in X-Linked Dystonia Parkinsonism-Related TAF1 Isoforms.

TAF1 TAF1L

7.69e-07231234403156
Pubmed

Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1.

CD2AP ASAP1 SH3KBP1

1.46e-062531312029088
Pubmed

Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.

ASAP2 ARHGEF7 CD2AP ASAP1

2.15e-0610331421706016
Pubmed

Direct interaction of HIV gp120 with neuronal CXCR4 and CCR5 receptors induces cofilin-actin rod pathology via a cellular prion protein- and NOX-dependent mechanism.

NCF1C NCF1B

2.31e-06331233705493
Pubmed

Reactive oxygen species and p47phox activation are essential for the Mycobacterium tuberculosis-induced pro-inflammatory response in murine microglia.

NCF1C NCF1B

2.31e-06331218036262
Pubmed

Inhibition of NADPH oxidase by apocynin attenuates progression of atherosclerosis.

NCF1C NCF1B

2.31e-06331223965970
Pubmed

Transient loss of resistance to pulmonary tuberculosis in p47(phox-/-) mice.

NCF1C NCF1B

2.31e-06331210678931
Pubmed

Colitis susceptibility in p47(phox-/-) mice is mediated by the microbiome.

NCF1C NCF1B

2.31e-06331227044504
Pubmed

Suppression of microglial inflammatory activity by myelin phagocytosis: role of p47-PHOX-mediated generation of reactive oxygen species.

NCF1C NCF1B

2.31e-06331217167081
Pubmed

Mice lacking NCF1 exhibit reduced growth of implanted melanoma and carcinoma tumors.

NCF1C NCF1B

2.31e-06331224358335
Pubmed

Molecular characterization of the mouse p47-phox (Ncf1) gene and comparative analysis of the mouse p47-phox (Ncf1) gene to the human NCF1 gene.

NCF1C NCF1B

2.31e-06331210891396
Pubmed

P47phox-/- mice are compromised in expansion and activation of CD8+ T cells and susceptible to Trypanosoma cruzi infection.

NCF1C NCF1B

2.31e-06331225474113
Pubmed

NADPH oxidase in bone marrow-derived cells mediates pulmonary ischemia-reperfusion injury.

NCF1C NCF1B

2.31e-06331218787174
Pubmed

NAD(P)H oxidase subunit p47phox is elevated, and p47phox knockout prevents diaphragm contractile dysfunction in heart failure.

NCF1C NCF1B

2.31e-06331226209274
Pubmed

Deficient production of reactive oxygen species leads to severe chronic DSS-induced colitis in Ncf1/p47phox-mutant mice.

NCF1C NCF1B

2.31e-06331224873968
Pubmed

p47(phox) is required for afferent arteriolar contractile responses to angiotensin II and perfusion pressure in mice.

NCF1C NCF1B

2.31e-06331222184329
Pubmed

Macrophage-derived reactive oxygen species protects against autoimmune priming with a defined polymeric adjuvant.

NCF1C NCF1B

2.31e-06331226455429
Pubmed

Superoxide generation from Kupffer cells contributes to hepatocarcinogenesis: studies on NADPH oxidase knockout mice.

NCF1C NCF1B

2.31e-06331215513930
Pubmed

NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease.

NCF1C NCF1B

2.31e-06331211018074
Pubmed

Conditional haploinsufficiency of NCF1 (encoding p47(phox)), a signaling gene with a heterozygous phenotype potentially subject to natural selection.

NCF1C NCF1B

2.31e-06331215626477
Pubmed

Phosphoinositide 3-kinase regulates the phosphorylation of NADPH oxidase component p47(phox) by controlling cPKC/PKCdelta but not Akt.

NCF1C NCF1B

2.31e-06331215033459
Pubmed

Natural Loss-of-Function Mutations in Qa2 and NCF1 Cause the Spread of Mannan-Induced Psoriasis.

NCF1C NCF1B

2.31e-06331233545139
Pubmed

Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis.

NCF1C NCF1B

2.31e-06331220142487
Pubmed

Enhanced host defense after gene transfer in the murine p47phox-deficient model of chronic granulomatous disease.

NCF1C NCF1B

2.31e-0633129116268
Pubmed

Mice producing less reactive oxygen species are relatively resistant to collagen glycopeptide vaccination against arthritis.

NCF1C NCF1B

2.31e-06331220686129
Pubmed

NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity.

NCF1C NCF1B

2.31e-06331219077231
Pubmed

Neutrophil-derived ROS contribute to oxidative DNA damage induction by quartz particles.

NCF1C NCF1B

2.31e-06331220828610
Pubmed

p47phox Phox homology domain regulates plasma membrane but not phagosome neutrophil NADPH oxidase activation.

NCF1C NCF1B

2.31e-06331220817944
Pubmed

Angiotensin II induced catabolic effect and muscle atrophy are redox dependent.

NCF1C NCF1B

2.31e-06331221570954
Pubmed

p47(phox) contributes to albuminuria and kidney fibrosis in mice.

NCF1C NCF1B

2.31e-06331225565313
Pubmed

Reduction of NADPH-oxidase activity ameliorates the cardiovascular phenotype in a mouse model of Williams-Beuren Syndrome.

NCF1C NCF1B

2.31e-06331222319452
Pubmed

Early determinants of H2O2-induced endothelial dysfunction.

NCF1C NCF1B

2.31e-06331216895801
Pubmed

Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis.

NCF1C NCF1B

2.31e-06331220690191
Pubmed

Endosomal acidification and activation of NADPH oxidase isoforms are upstream events in hyperosmolarity-induced hepatocyte apoptosis.

NCF1C NCF1B

2.31e-06331216772302
Pubmed

Distinct ubiquitin binding modes exhibited by SH3 domains: molecular determinants and functional implications.

CD2AP SH3KBP1

2.31e-06331224039852
Pubmed

Knockout of neutrophil cytosolic factor 1 ameliorates neuroinflammation and motor deficit after traumatic brain injury.

NCF1C NCF1B

2.31e-06331239357591
Pubmed

Aging increases vulnerability to stress-induced depression via upregulation of NADPH oxidase in mice.

NCF1C NCF1B

2.31e-06331232504071
Pubmed

Effect of p47phox gene deletion on ROS production and oxygen sensing in mouse carotid body chemoreceptor cells.

NCF1C NCF1B

2.31e-06331216280459
Pubmed

Inhibition of T cell activation and function by the adaptor protein CIN85.

CD2AP SH3KBP1

2.31e-06331230723173
Pubmed

Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease.

NCF1C NCF1B

2.31e-06331218185592
Pubmed

Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesion.

NCF1C NCF1B

2.31e-06331212958309
Pubmed

Genetic demonstration of p47phox-dependent superoxide anion production in murine vascular smooth muscle cells.

NCF1C NCF1B

2.31e-06331211435342
Pubmed

Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8+ T Cell Activation via Cross-Presentation in Type 1 Diabetes.

NCF1C NCF1B

2.31e-06331231118934
Pubmed

Female mice lacking p47phox have altered adipose tissue gene expression and are protected against high fat-induced obesity.

NCF1C NCF1B

2.31e-06331223482812
Pubmed

NCF1-dependent production of ROS protects against lupus by regulating plasmacytoid dendritic cell development and functions.

NCF1C NCF1B

2.31e-06331236853827
Pubmed

Prolonged production of reactive oxygen species in response to B cell receptor stimulation promotes B cell activation and proliferation.

NCF1C NCF1B

2.31e-06331223024271
Pubmed

Virulence comparisons of Aspergillus nidulans mutants are confounded by the inflammatory response of p47phox-/- mice.

NCF1C NCF1B

2.31e-06331216041040
Pubmed

The p47(phox-/-) mouse model of chronic granulomatous disease has normal granuloma formation and cytokine responses to Mycobacterium avium and Schistosoma mansoni eggs.

NCF1C NCF1B

2.31e-06331210085000
Pubmed

The Pro-Oncogenic Adaptor CIN85 Acts as an Inhibitory Binding Partner of Hypoxia-Inducible Factor Prolyl Hydroxylase 2.

CD2AP SH3KBP1

2.31e-06331231142511
Pubmed

Oxidants from nicotinamide adenine dinucleotide phosphate oxidase are involved in triggering cell proliferation in the liver due to peroxisome proliferators.

NCF1C NCF1B

2.31e-06331210987289
Pubmed

Ncf1 (p47phox) is essential for direct regulatory T cell mediated suppression of CD4+ effector T cells.

NCF1C NCF1B

2.31e-06331221253614
Pubmed

TAFII55 binding to TAFII250 inhibits its acetyltransferase activity.

TAF1 TAF1L

2.31e-06331211592977
Pubmed

CFBP is a novel tyrosine-phosphorylated protein that might function as a regulator of CIN85/CD2AP.

CD2AP SH3KBP1

2.31e-06331216895919
Pubmed

Methamphetamine alters occludin expression via NADPH oxidase-induced oxidative insult and intact caveolae.

NCF1C NCF1B

2.31e-06331221435178
Pubmed

Synergistic innate and adaptive immune response to combination immunotherapy with anti-tumor antigen antibodies and extended serum half-life IL-2.

NCF1C NCF1B

2.31e-06331225873172
Pubmed

Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene.

NCF1C NCF1B

2.31e-06331215310853
Pubmed

Intermittent hypoxia has organ-specific effects on oxidative stress.

NCF1C NCF1B

2.31e-06331218703411
Pubmed

Mycobacterial infection induces higher interleukin-1β and dysregulated lung inflammation in mice with defective leukocyte NADPH oxidase.

NCF1C NCF1B

2.31e-06331229228045
Pubmed

Mycobacteria-induced Gr-1+ subsets from distinct myeloid lineages have opposite effects on T cell expansion.

NCF1C NCF1B

2.31e-06331217307863
Pubmed

Exogenous PP2A inhibitor exacerbates the progression of nonalcoholic fatty liver disease via NOX2-dependent activation of miR21.

NCF1C NCF1B

2.31e-06331231393787
Pubmed

Vascular effects following homozygous disruption of p47(phox) : An essential component of NADPH oxidase.

NCF1C NCF1B

2.31e-06331210725280
Pubmed

Generation of reactive oxygen species (ROS) is a key factor for stimulation of macrophage proliferation by ceramide 1-phosphate.

NCF1C NCF1B

2.31e-06331222155727
Pubmed

Ncf1 affects osteoclast formation but is not critical for postmenopausal bone loss.

NCF1C NCF1B

2.31e-06331227829407
Pubmed

Ncf1 Governs Immune Niches in the Lung to Mediate Pulmonary Inflammation in Mice.

NCF1C NCF1B

2.31e-06331234970267
Pubmed

Germ-free mice deficient of reactive oxygen species have increased arthritis susceptibility.

NCF1C NCF1B

2.31e-06331225689796
Pubmed

Mechanism of endoplasmic reticulum stress-induced vascular endothelial dysfunction.

NCF1C NCF1B

2.31e-06331224576409
Pubmed

The presence of p47phox in liver parenchymal cells is a key mediator in the pathogenesis of alcoholic liver steatosis.

NCF1C NCF1B

2.31e-06331222376231
Pubmed

Opposing roles of p47phox in basal versus angiotensin II-stimulated alterations in vascular O2- production, vascular tone, and mitogen-activated protein kinase activation.

NCF1C NCF1B

2.31e-06331214993144
Pubmed

Leishmania amazonensis amastigotes trigger neutrophil activation but resist neutrophil microbicidal mechanisms.

NCF1C NCF1B

2.31e-06331223918780
Pubmed

NADPH oxidase NOX2 mediates TLR2/6-dependent release of GM-CSF from endothelial cells.

NCF1C NCF1B

2.31e-06331228274989
Pubmed

The p47phox deficiency significantly attenuates the pathogenicity of Chlamydia muridarum in the mouse oviduct but not uterine tissues.

NCF1C NCF1B

2.31e-06331226645958
Pubmed

Inhibition of NADPH oxidase promotes alternative and anti-inflammatory microglial activation during neuroinflammation.

NCF1C NCF1B

2.31e-06331222050439
Pubmed

The vascular NADPH oxidase subunit p47phox is involved in redox-mediated gene expression.

NCF1C NCF1B

2.31e-06331212031896
Pubmed

Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II.

NCF1C NCF1B

2.31e-06331212364355
Pubmed

NAD(P)H oxidase-derived superoxide mediates hypercholesterolemia-induced leukocyte-endothelial cell adhesion.

NCF1C NCF1B

2.31e-06331211249873
Pubmed

Ncf1 (p47phox) polymorphism determines oxidative burst and the severity of arthritis in rats and mice.

NCF1C NCF1B

2.31e-06331215936744
Pubmed

NADPH oxidase modulates myocardial Akt, ERK1/2 activation, and angiogenesis after hypoxia-reoxygenation.

NCF1C NCF1B

2.31e-06331217220182
Pubmed

NADPH oxidase promotes neutrophil extracellular trap formation in pulmonary aspergillosis.

NCF1C NCF1B

2.31e-06331224549323
Pubmed

NADPH oxidase p47phox siRNA attenuates adventitial fibroblasts proliferation and migration in apoE(-/-) mouse.

NCF1C NCF1B

2.31e-06331225628043
Pubmed

NOX2-Deficient Neutrophils Facilitate Joint Inflammation Through Higher Pro-Inflammatory and Weakened Immune Checkpoint Activities.

NCF1C NCF1B

2.31e-06331234557202
Pubmed

Reactive Oxygen Species Regulate Both Priming and Established Arthritis, but with Different Mechanisms.

NCF1C NCF1B

2.31e-06331228467721
Pubmed

P47(phox)-deficient NADPH oxidase defect in neutrophils of diabetic mouse strains, C57BL/6J-m db/db and db/+.

NCF1C NCF1B

2.31e-06331210670582
Pubmed

NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity.

NCF1C NCF1B

2.31e-06331220881184
Pubmed

Regulated expression of TAF1 in 1-cell mouse embryos.

TAF1 TAF1L

2.31e-06331216822332
Pubmed

The p47phox mouse knock-out model of chronic granulomatous disease.

NCF1C NCF1B

2.31e-0633127650482
Pubmed

Direct Comparison of a Natural Loss-Of-Function Single Nucleotide Polymorphism with a Targeted Deletion in the Ncf1 Gene Reveals Different Phenotypes.

NCF1C NCF1B

2.31e-06331226528554
Pubmed

The role of reactive oxygen species in immunopathogenesis of rheumatoid arthritis.

NCF1C NCF1B

2.31e-06331219052348
Pubmed

Disseminated trichosporonosis in a murine model of chronic granulomatous disease.

NCF1C NCF1B

2.31e-06331212868577
Pubmed

Functional substitution for TAF(II)250 by a retroposed homolog that is expressed in human spermatogenesis.

TAF1 TAF1L

2.31e-06331212217962
Pubmed

Mechanism of endothelial cell NADPH oxidase activation by angiotensin II. Role of the p47phox subunit.

NCF1C NCF1B

2.31e-06331212560337
InteractionCD2 interactions

PSTPIP1 CD2AP SH3KBP1

4.65e-0623293int:CD2
InteractionCBLB interactions

ARHGEF7 CD2AP ASAP1 SH3KBP1

2.14e-05115294int:CBLB
Cytoband7q11.23

NCF1C NCF1B

1.97e-03973127q11.23
CytobandEnsembl 112 genes in cytogenetic band chr15q24

MAN2C1 PSTPIP1

3.10e-03122312chr15q24
CytobandEnsembl 112 genes in cytogenetic band chr7q11

NCF1C NCF1B

1.44e-02271312chr7q11
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

ASAP2 ARHGEF7 MYO10 ASAP1

6.87e-05206204682
GeneFamilyX-linked mental retardation|Rho GTPase activating proteins|BAR-PH domain containing

ASAP2 ASAP1

1.57e-04172021291
GeneFamilyArfGAPs

ASAP2 ASAP1

6.01e-0433202395
GeneFamilyAnkyrin repeat domain containing

ASAP2 HECTD1 ASAP1

2.28e-03242203403
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

ARHGEF7 PREX2

2.39e-0366202722
CoexpressionAIZARANI_LIVER_C13_LSECS_2

ANPEP ARHGEF7 MYO10 PREX2 ASAP1

1.91e-05283315M39117
ToppCell(5)_Dendritic_cell-(51)_cDC1|(5)_Dendritic_cell / shred on Cell_type and subtype

LIPC PSTPIP1 ANPEP ASAP1

1.58e-06123314d46cfdf8b3e561d8db33903207d5151cdb2a91d4
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Goblet_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DIXDC1 P2RX1 ANPEP CFAP65

7.65e-0618331407c18ccc45ddc9c22e482bd9ffb87f46ebcfe473
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-large_intestine_goblet_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DIXDC1 P2RX1 ANPEP CFAP65

7.65e-061833145a936fb07074cec753bf19e3e3e52499605ea22c
ToppCell10x5'-Liver-Myeloid_Dendritic-DC1|Liver / Manually curated celltypes from each tissue

ASAP2 ANPEP PREX2 ASAP1

8.15e-06186314e823529ffd06352c6bdec102f221fdf27f7c7369
ToppCellCOPD-Stromal-Pericyte|Stromal / Disease state, Lineage and Cell class

ARHGEF7 MYO10 ASAP1 FAM182B

8.33e-06187314406ecd1dabb3ed8d871aef159f7bd1e383434953
ToppCellIPF-Stromal-Pericyte|Stromal / Disease state, Lineage and Cell class

ARHGEF7 MYO10 PREX2 ASAP1

9.63e-061943143892b188f424ffb80f3c75a1b6709a21c1e1601d
ToppCelldroplet-Limb_Muscle-MUSCLE|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HECTD1 MYO10 PREX2 ASAP1

9.63e-06194314e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCell(1)_Control_(PBS)-(1)_VE-Cad+_vascular_cells|World / Stress and Cell class

ARHGEF7 MYO10 PREX2 CD2AP

9.82e-061953146b5d3ecec0c00ebfc889dc6235390ff53b5c0b6a
ToppCellbackground-Endothelial_cells|background / Sample and Cell Type and Tumor Cluster (all cells)

ASAP2 MYO10 PREX2 ASAP1

1.00e-05196314e6fb0bfab1779ec64a8c35d01519eaafbf62e977
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PALM3 C3 ATP8A1

9.99e-051303136434d9106ccb38786dad36fab80163dfc07b6eb7
ToppCellControl-Epithelial_airway|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

C3 ANPEP CFAP65

1.78e-0415831335aee1c3b92169e73569331022833cb44ab7e7e8
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-3|TCGA-Skin / Sample_Type by Project: Shred V9

ATP8A1 MYO10 ASAP1

1.81e-04159313fb222c42f66901852b01cec073ec0732245ee973
ToppCelldroplet-Spleen-SPLEEN-1m-Myeloid-granulocyte|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C3 CARD10 FHIP1B

2.02e-04165313b671c6a950e70f64776c2104baccb3dc2bb6a1ba
ToppCellmetastatic_Lymph_Node-Myeloid_cells-CD141+_DCs|metastatic_Lymph_Node / Location, Cell class and cell subclass

ANPEP PREX2 ASAP1

2.05e-041663139f14e3ef19d5903278c040be1c477501237173fa
ToppCellPND07-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LIPC P2RX1 ASAP1

2.36e-04174313a3f4981b10afa9d41a1c66c7f98522a8a534f82b
ToppCellPND07-Immune-Immune_Myeloid-Megakaryocyte/Platelet|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LIPC P2RX1 ASAP1

2.36e-041743136cc108dde4b3f98a78a6040280f0d5e4aaa5bd75
ToppCellPND07-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LIPC P2RX1 ASAP1

2.36e-041743134b8bc5568e36031c8ecf001bb646809038c23919
ToppCellnormal_Pleural_Fluid-Myeloid_cells-CD141+_DCs|normal_Pleural_Fluid / Location, Cell class and cell subclass

ANPEP PREX2 ASAP1

2.44e-04176313195393b38f1335f2cb96125616d75c164a6026c2
ToppCellcellseq2-Mesenchymal-Myocytic-Myocytic_1-Pericyte|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MYO10 ASAP1 FAM182B

2.48e-0417731368263456a3c93cd195b321b309ff59e156d732fe
ToppCellcellseq2-Mesenchymal-Myocytic-Myocytic_1|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MYO10 ASAP1 FAM182B

2.48e-04177313e415e448c37adc102d766235e9953dec32c021f1
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO10 PREX2 CD2AP

2.52e-0417831301dafd19de04eff459253eaa9a35debf8f3deedf
ToppCellnormal_Lymph_Node-Myeloid_cells-CD141+_DCs|normal_Lymph_Node / Location, Cell class and cell subclass

ASAP2 ANPEP ASAP1

2.56e-04179313ec995ccd6e1dbd06287ad836c232d9aed1cf94a8
ToppCellPND28-Immune-Immune_Myeloid-Megakaryocyte/Platelet|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DIXDC1 P2RX1 ASAP1

2.56e-04179313362c003503190dc272fa89185a83a65e063d7a67
ToppCellPND28-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DIXDC1 P2RX1 ASAP1

2.56e-041793137d2e6bde00a9ab4cb21bd48b140ce205e36f9d77
ToppCellPND28-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DIXDC1 P2RX1 ASAP1

2.56e-04179313e0eec8d48868c76c3e879f219357c62ceff1bc76
ToppCellAT2_cells-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

PALM3 C3 LIPC

2.65e-04181313ed0ea67f0607073aedf153f8d1073b35e46127c3
ToppCelldroplet-Marrow-nan-3m-Myeloid-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD2AP ASAP1 SH3KBP1

2.69e-04182313f8c73baaaca145e2efc48f10f636feb79c8fc779
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

P2RX1 ANPEP ARHGEF7

2.69e-04182313ffe500d78a89dc6b4d05bab1664e7f30c94fb8d9
ToppCell10x5'-lymph-node_spleen-Myeloid_Dendritic-DC1|lymph-node_spleen / Manually curated celltypes from each tissue

ASAP2 ANPEP ASAP1

2.74e-04183313c9e3d91f4c3395a73295b92e25608e0effb5d241
ToppCellLPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

C3 ATP8A1 CD2AP

2.78e-0418431342ce855b4f8475a8298192feec785bdc69bc5bb0
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

P2RX1 ANPEP ARHGEF7

2.78e-0418431394748f63947db79a6b4540e3090a63689fdd9452
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

P2RX1 ANPEP ARHGEF7

2.78e-04184313819b277ecced7b415e363c7e7ddbc6f3b2d296de
ToppCelldroplet-Marrow-nan-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD2AP ASAP1 SH3KBP1

2.82e-041853137adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c5-WDR74|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

CARD10 P2RX1 ANPEP

2.82e-0418531368edb1bb03ed221d49e583123ca4de14252d7bc5
ToppCelldroplet-Thymus-nan-24m-Myeloid-Plasma_cells_and_B_cells|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PALM3 LIPC ERLEC1

2.82e-04185313e583f6601f9ed79b0b23d2f9426a4ba8b969230b
ToppCellILEUM-inflamed-(3)_MNP-(3)_pDC|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

P2RX1 ARHGEF7 CD2AP

2.82e-04185313308a98f111895071d8772bc010554471cc12fab2
ToppCelldroplet-Heart-nan-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO10 PREX2 CD2AP

2.87e-041863130ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDAN1 ASAP2 MYO10

2.87e-041863134ae3c0fe8640a8d029875cf3f0f5ffbba38e85f8
ToppCelldroplet-Tongue-nan-24m-Epithelial-parabasal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PSTPIP1 ANPEP SH3KBP1

2.87e-0418631318c06041c6c8a0ebac17b3c8aaebd67e652d315a
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ARHGEF7 MYO10 PREX2

2.87e-04186313888e85a025bd982d36c910db0f5a3385b1ca3b28
ToppCellPCW_05-06-Endothelial-Endothelial_mature-endo_venous_(13)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

CARD10 ATP8A1 ANPEP

2.92e-0418731303de3c2df31bca0dc4e3718bada708d8fe8b69b9
ToppCellE17.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ASAP2 PREX2 CD2AP

2.96e-0418831359f276e23c8380bae57d7ecca3a8b83df4bc150b
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK-T_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PSTPIP1 ATP8A1 SH3KBP1

3.01e-04189313b87d586a9570fa54f3e0c6bd4731c5badcaedae6
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

C3 MYO10 PREX2

3.01e-0418931342ab4cc5fbf8580841f31889446fe4499df1a464
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PSTPIP1 ATP8A1 SH3KBP1

3.01e-04189313823d6debd09e440ddf36c54af24a5f20e222a21e
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK-T_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PSTPIP1 ATP8A1 SH3KBP1

3.01e-0418931347c2b419b081d5bf75da5e3d9a0e05a70362dfe7
ToppCellrenal_cortex_nuclei-Adult_normal_reference|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

DIXDC1 ARHGEF7 MYO10

3.01e-04189313a48df46274d51e84ffb40264646de7346104efb9
ToppCellFetal_29-31_weeks-Immune-monocyte-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PSTPIP1 P2RX1 ANPEP

3.05e-04190313ad297172a74a80ed5c10f921e15efd1da0fd2d6b
ToppCellCOVID-19-Heart-EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

ASAP2 ARHGEF7 PREX2

3.05e-04190313a21653bfb7bafbc273f94fa7c13bfb48cf8fd562
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ASAP2 PREX2 CD2AP

3.05e-04190313d87b9e9ca863270a9c7f61674271a6440c97d1f4
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-D|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

C3 NCF1C NCF1B

3.10e-041913137d00796459f4ff0ab7f06a8379b2d34e76b078b2
ToppCellRA-09._Endothelium_I|World / Chamber and Cluster_Paper

MYO10 PREX2 ASAP1

3.10e-04191313c8a0c2af119bc34a8f694a7d30642f28002c84b9
ToppCellSmart-seq2-bone_marrow_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

NCF1C NCF1B ASAP1

3.10e-04191313d4f77c73311d1149466bbfe4adbd6a301946ec90
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

C3 MYO10 PREX2

3.10e-04191313a90c8ab2077e52bbc998457c85a1b9867f9c8c93
ToppCellIPF-Epithelial-Club|Epithelial / Disease state, Lineage and Cell class

C3 ATP8A1 ANPEP

3.15e-04192313356e7a820b744a0ac87352a8d0e6e8d9fa9ed7d2
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ASAP2 PREX2 CD2AP

3.15e-04192313285a9d332a1e07b94f222d4b518dd56928b9e075
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ASAP2 HECTD1 CD2AP

3.15e-041923132510f22197502f60fd266b7f42eff040f25b8ae7
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ASAP2 HECTD1 CD2AP

3.15e-04192313e8e316f396834bcd34843e56e1d86f310fd6aada
ToppCellSmart-seq2-bone_marrow_(Smart-seq2)-myeloid-myeloid_granulocytic|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

NCF1C NCF1B ASAP1

3.20e-04193313e1855cff9a6bcfda9188b9fdf6c9d698405da990
ToppCellwk_15-18-Hematologic-Myeloid-DC1|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

PSTPIP1 ANPEP ASAP1

3.20e-04193313df9a4a459af51c2040ad832b580c333a135e374e
ToppCellRV-10._Endothelium_II|World / Chamber and Cluster_Paper

ASAP2 CD2AP ASAP1

3.20e-041933132531266bc57339d4e2b22a88817008e32b8c1598
ToppCelldroplet-Tongue-TONGUE-1m-Epithelial-parabasal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PSTPIP1 ANPEP SH3KBP1

3.20e-0419331355eab7d2574e9cc2ed8f08e0a7ca7cbf90fb5818
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic-lymphocyte-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

FHIP1B ZNF569 MYO10

3.25e-041943138f4b63b0b9a40765205e4ca6bd94a675a83dbe3d
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DIXDC1 LIPC ANPEP

3.25e-0419431370185c0b8e0f4e896645b17a243482ba3cdf4a5d
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_hypoxia/MES-E|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

P2RX1 ANPEP NCF1C

3.30e-04195313d53585715c7f5827c4f5a6db11cb31857ee9d4f0
ToppCellBAL-Severe-cDC_11|Severe / Compartment, Disease Groups and Clusters

ANPEP PREX2 ASAP1

3.30e-041953132d31a1c2878c86a49a278b6c7decafabf26c3a5c
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_hypoxia/MES-C|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ANPEP NCF1C NCF1B

3.30e-04195313de47651c84da62f273535fc80115f0154746699d
ToppCellfacs-Heart-RA-18m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ASAP2 MYO10 PREX2

3.30e-0419531330c75761079fa1e1a3b84d23c88a222f459d5ce5
ToppCellBronchial-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_arterial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CARD10 ASAP2 PREX2

3.34e-04196313915e4a7422058be246b54760df31e8a607310625
ToppCelldroplet-Tongue-nan-3m-Epithelial-parabasal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PSTPIP1 ANPEP SH3KBP1

3.34e-04196313159061fd0961b2cfb5941d403acc5b395dd0d3a0
ToppCelldistal-Hematologic-Interstitial_Macrophage-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ANPEP NCF1C NCF1B

3.34e-04196313e4f40274df940e0996c555082f2bb4f99e5b0881
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_secretory-Secretory_Club|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PALM3 C3 ANPEP

3.40e-0419731301e9505d947e5a5f005d1eab96301f84fc194809
ToppCellmoderate-Epithelial-Secretory|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

C3 ANPEP ERLEC1

3.45e-041983137ecce5e266bb08797088cc8f8309e0c7b48df5c9
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_2-AT2|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

C3 ATP8A1 ERLEC1

3.45e-04198313d12f37527399038a8f030b45b176bda5c7c8a7ad
ToppCellControl_saline-Epithelial_airway-airway_epithelial|Control_saline / Treatment groups by lineage, cell group, cell type

C3 ANPEP CFAP65

3.45e-04198313e7aa42e5fbd42c68f50cda4a8f3aa464c862c007
ToppCellControl_saline-Epithelial_airway|Control_saline / Treatment groups by lineage, cell group, cell type

C3 ANPEP CFAP65

3.45e-04198313e6863238e022ecfb6a8e3f4b7661b376e92c5d8f
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1-2_Progenitor-AT2_Progenitor|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

C3 ATP8A1 CD2AP

3.45e-0419831382bcd44f8744e7e8477fbfd871a52f3d1a8b3adc
ToppCell10x3'2.3-week_17-19-Endothelial-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

CARD10 MYO10 PREX2

3.45e-041983131e83bec16dcd60460422625f89952ff506d6be51
ToppCell10x3'2.3-week_17-19-Endothelial|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

CARD10 MYO10 PREX2

3.45e-041983132630a7a6e56febe5c0b0bde70dd7292fa1650c47
ToppCellLPS_IL1RA_TNF-Epithelial_airway-airway_epithelial-Airway-Club|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

C3 ANPEP CFAP65

3.50e-041993138649c2380285a668782d75eb076ce548eed0911d
ToppCellSkin-Fibroblasts|Skin / Skin and Kidney Cells in Lupus Nephritis Patients.

C3 LIPC ANPEP

3.55e-04200313f777eadf571a1a6d246da87346a9cb9d511c2e81
ToppCellLPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_only / Treatment groups by lineage, cell group, cell type

C3 ATP8A1 CD2AP

3.55e-042003132dadf317a42a7e27cc1fac74f91b806c93a57108
ToppCellLPS_only-Epithelial_alveolar-AT_1|LPS_only / Treatment groups by lineage, cell group, cell type

C3 ATP8A1 CD2AP

3.55e-042003139a6ae40f3e17cd44ee5fd73260713b920aa2ea15
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_hypoxia/MES-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

C3 PSTPIP1 NCF1C

3.55e-042003135f1de1f9305e1784c12d526f6c8bdd7d56229f9b
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_hypoxia/MES-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ANPEP NCF1C NCF1B

3.55e-04200313851c57187db8bc91a393655bca5f13e787a723d4
ToppCell(51)_cDC1|World / shred on Cell_type and subtype

LIPC ANPEP ASAP1

3.76e-04204313a8cf4180c406674b7541917d1fc6127686ba5f8a
DrugMfpa

TAF1 TAF1L

5.38e-063312CID003035615
Diseasenephrotic syndrome (implicated_via_orthology)

LIPC CD2AP SH3KBP1

1.89e-0624303DOID:1184 (implicated_via_orthology)
Diseasechronic granulomatous disease (implicated_via_orthology)

NCF1C NCF1B

9.97e-065302DOID:3265 (implicated_via_orthology)
Diseasetauopathy (implicated_via_orthology)

CD2AP SH3KBP1

4.47e-0510302DOID:680 (implicated_via_orthology)
Diseaserheumatoid arthritis (implicated_via_orthology)

NCF1C NCF1B

6.55e-0512302DOID:7148 (implicated_via_orthology)
Diseaseend stage renal disease (implicated_via_orthology)

LIPC CD2AP

1.88e-0420302DOID:783 (implicated_via_orthology)
DiseaseInsulin Sensitivity

C3 LIPC

1.71e-0360302C0920563
DiseaseInsulin Resistance

C3 LIPC

1.71e-0360302C0021655
Diseaseatrophic macular degeneration, age-related macular degeneration, wet macular degeneration

C3 LIPC

1.71e-0360302EFO_0001365, EFO_0004683, EFO_1001492
Diseaseage-related macular degeneration, COVID-19

C3 LIPC

2.25e-0369302EFO_0001365, MONDO_0100096

Protein segments in the cluster

PeptideGeneStartEntry
EEEEEENVIGNWFWE

BHLHB9

166

Q6PI77
VVVGTWNQEEHIEWA

ERLEC1

376

Q96DZ1
WVQVPAHEWGHAEEL

CARD10

986

Q9BWT7
PGWEGKIVAWVEEDH

DIXDC1

666

Q155Q3
IIGKDTWVEHWPEED

C3

1621

P01024
IHVTRVEEGGWWEGT

ARHGEF7

211

Q14155
IAQGGEEEWDFAWEQ

ANPEP

801

P15144
DINEEVEEGWWSGTL

CD2AP

136

Q9Y5K6
EVLREWEDHHEEPGW

CDAN1

461

Q8IWY9
GAWEIVHWEKVAVGE

ATP8A1

141

Q9Y2Q0
WVKEDRGIVEVVWEG

PALM3

266

A6NDB9
TWQLQWDELGDGVEE

FHIP1B

111

Q8N612
LEVILEGEDGWWTVE

PSTPIP1

386

O43586
IIVDGEEDQEWWIGH

ASAP2

971

O43150
EEDQEWWIGHIDGDP

ASAP2

976

O43150
VIWGIEVAEELHWKG

CFAP65

141

Q6ZU64
REGLVWEDIDWIDNG

MYO10

476

Q9HD67
IIHGWSVDGVLENWI

LIPC

86

P11150
GEAVEVIHKLLDGWW

NCF1B

251

A6NI72
GEAVEVIHKLLDGWW

NCF1C

226

A8MVU1
WNVEEEEHEVGICTW

FAM182B

11

Q5T319
VTGELHNGWIDVTWD

HECTD1

1301

Q9ULT8
GEVIIVTGEEDQEWW

ASAP1

1091

Q9ULH1
VTGEEDQEWWIGHIE

ASAP1

1096

Q9ULH1
DQEWWIGHIEGQPER

ASAP1

1101

Q9ULH1
EVHLCWESDGEGLVW

MAN2C1

96

Q9NTJ4
GVVGITIDWHCDLDW

P2RX1

251

P51575
AEEEEVIIGSWFWEE

GPRASP1

836

Q5JY77
QLHWEDSIIWDGEDI

TAF1L

426

Q8IZX4
TQLHWEDDIIWDGED

TAF1

406

P21675
EVVGEVEEGWWEGVL

SH3KBP1

126

Q96B97
RHGIIVDWDTVQDIW

ACTL7A

136

Q9Y615
LEVLEEWQSHIEGWE

PREX2

221

Q70Z35
WLPGDEIDWETENHD

ZMYND11

86

Q15326
RHWQGEIWGVDEHQK

ZNF569

76

Q5MCW4