Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	xylose binding	SLC2A14 SLC2A3	7.73e-06	2	56	2	GO:0033222
GeneOntologyMolecularFunction	galactose transmembrane transporter activity	SLC2A14 SLC2A3	1.15e-04	6	56	2	GO:0005354
GeneOntologyMolecularFunction	dehydroascorbic acid transmembrane transporter activity	SLC2A14 SLC2A3	2.14e-04	8	56	2	GO:0033300
GeneOntologyMolecularFunction	galactoside binding	SLC2A14 SLC2A3	2.75e-04	9	56	2	GO:0016936
GeneOntologyMolecularFunction	D-glucose binding	SLC2A14 SLC2A3	6.88e-04	14	56	2	GO:0005536
Domain	Glc_transpt_3	SLC2A14 SLC2A3	8.21e-06	2	54	2	IPR002945
Domain	-	DCBLD1 CSMD1 ZZEF1	4.57e-04	52	54	3	2.60.120.290
Domain	Sushi	FBLN7 C2 CSMD1	4.57e-04	52	54	3	PF00084
Domain	CCP	FBLN7 C2 CSMD1	5.11e-04	54	54	3	SM00032
Domain	SUSHI	FBLN7 C2 CSMD1	5.68e-04	56	54	3	PS50923
Domain	Sushi_SCR_CCP_dom	FBLN7 C2 CSMD1	5.99e-04	57	54	3	IPR000436
Domain	CUB_dom	DCBLD1 CSMD1 ZZEF1	5.99e-04	57	54	3	IPR000859
Domain	Sugar/inositol_transpt	SLC2A14 SLC2A3	7.30e-04	14	54	2	IPR003663
Domain	SUGAR_TRANSPORT_2	SLC2A14 SLC2A3	1.09e-03	17	54	2	PS00217
Domain	SUGAR_TRANSPORT_1	SLC2A14 SLC2A3	2.17e-03	24	54	2	PS00216
Domain	Galactose-bd-like	MEP1B DCBLD1 ZZEF1	2.54e-03	94	54	3	IPR008979
Domain	Sugar_transporter_CS	SLC2A14 SLC2A3	3.85e-03	32	54	2	IPR005829
Domain	MFS_sugar_transport-like	SLC2A14 SLC2A3	4.85e-03	36	54	2	IPR005828
Domain	Sugar_tr	SLC2A14 SLC2A3	4.85e-03	36	54	2	PF00083
Pathway	REACTOME_METABOLISM_OF_WATER_SOLUBLE_VITAMINS_AND_COFACTORS	FASN FLAD1 SLC2A14 MTHFD2L SLC2A3	4.26e-05	120	46	5	MM14771
Pubmed	Neural Deletion of Glucose Transporter Isoform 3 Creates Distinct Postnatal and Adult Neurobehavioral Phenotypes.	MAP2 SLC2A14 SLC2A3	6.82e-07	11	57	3	30232223
Pubmed	Reprogramming- and pluripotency-associated membrane proteins in mouse stem cells revealed by label-free quantitative proteomics.	SLC2A14 SLC2A3	2.64e-06	2	57	2	23615220
Pubmed	Sex-Specific Life Course Changes in the Neuro-Metabolic Phenotype of Glut3 Null Heterozygous Mice: Ketogenic Diet Ameliorates Electroencephalographic Seizures and Improves Sociability.	SLC2A14 SLC2A3	2.64e-06	2	57	2	28324109
Pubmed	Expression of mouse-GLUT3 and human-GLUT3 glucose transporter proteins in brain.	SLC2A14 SLC2A3	2.64e-06	2	57	2	1734877
Pubmed	Expression of the brain-type glucose transporter is restricted to brain and neuronal cells in mice.	SLC2A14 SLC2A3	2.64e-06	2	57	2	1516757
Pubmed	Glucose Transporter 3 Potentiates Degranulation and Is Required for Platelet Activation.	SLC2A14 SLC2A3	2.64e-06	2	57	2	28663252
Pubmed	Sevoflurane Induces Learning and Memory Impairment in Young Mice Through a Reduction in Neuronal Glucose Transporter 3.	SLC2A14 SLC2A3	2.64e-06	2	57	2	31884568
Pubmed	Adult glut3 homozygous null mice survive to demonstrate neural excitability and altered neurobehavioral responses reminiscent of neurodevelopmental disorders.	SLC2A14 SLC2A3	2.64e-06	2	57	2	33482226
Pubmed	Temporal and spatial distribution of murine placental and brain GLUT3-luciferase transgene as a readout of in vivo transcription.	SLC2A14 SLC2A3	2.64e-06	2	57	2	23193055
Pubmed	Neuronal glucose transporter isoform 3 deficient mice demonstrate features of autism spectrum disorders.	SLC2A14 SLC2A3	2.64e-06	2	57	2	19506559
Pubmed	Gene expression of GLUT3 glucose transporter regulated by glucose in vivo in mouse brain and in vitro in neuronal cell cultures from rat embryos.	SLC2A14 SLC2A3	2.64e-06	2	57	2	8198523
Pubmed	Copy-Number Variation of the Glucose Transporter Gene SLC2A3 and Congenital Heart Defects in the 22q11.2 Deletion Syndrome.	SLC2A14 SLC2A3	2.64e-06	2	57	2	25892112
Pubmed	CD205+ polymorphonuclear myeloid-derived suppressor cells suppress antitumor immunity by overexpressing GLUT3.	SLC2A14 SLC2A3	2.64e-06	2	57	2	33368883
Pubmed	Glucose Transporter 3 is Essential for the Survival of Breast Cancer Cells in the Brain.	SLC2A14 SLC2A3	2.64e-06	2	57	2	31817208
Pubmed	Brain glucose transporter (Glut3) haploinsufficiency does not impair mouse brain glucose uptake.	SLC2A14 SLC2A3	2.64e-06	2	57	2	21316350
Pubmed	Neuronal functions, feeding behavior, and energy balance in Slc2a3+/- mice.	SLC2A14 SLC2A3	2.64e-06	2	57	2	18780771
Pubmed	Canine brain glucose transporter 3: gene sequence, phylogenetic comparisons and analysis of functional sites.	SLC2A14 SLC2A3	2.64e-06	2	57	2	8654954
Pubmed	Altered lactate metabolism in Huntington's disease is dependent on GLUT3 expression.	SLC2A14 SLC2A3	2.64e-06	2	57	2	29582588
Pubmed	Placental glucose and amino acid transport in calorie-restricted wild-type and Glut3 null heterozygous mice.	SLC2A14 SLC2A3	2.64e-06	2	57	2	22700768
Pubmed	Glucose transporter isoform-3-null heterozygous mutation causes sexually dimorphic adiposity with insulin resistance.	SLC2A14 SLC2A3	2.64e-06	2	57	2	18445753
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	MYH6 FASN MAP2 SLC2A14 RPS24 SAMM50 MARK2 YJEFN3 VIRMA SLC2A3 SDHA CACNA2D3	2.85e-06	1431	57	12	37142655
Pubmed	Network organization of the huntingtin proteomic interactome in mammalian brain.	MYH6 FASN MAP2 RPS6KA1 SLC2A14 MARK2 YJEFN3 SLC2A3	7.56e-06	621	57	8	22794259
Pubmed	Glucose transporter isoform-3 mutations cause early pregnancy loss and fetal growth restriction.	SLC2A14 SLC2A3	7.91e-06	3	57	2	17213475
Pubmed	NFκB up-regulation of glucose transporter 3 is essential for hyperactive mammalian target of rapamycin-induced aerobic glycolysis and tumor growth.	SLC2A14 SLC2A3	7.91e-06	3	57	2	25578782
Pubmed	Gestational changes of glucose transporter gene expression in the mouse placenta and decidua.	SLC2A14 SLC2A3	7.91e-06	3	57	2	8905482
Pubmed	Regular Exercise Enhances Cognitive Function and Intracephalic GLUT Expression in Alzheimer's Disease Model Mice.	SLC2A14 SLC2A3	7.91e-06	3	57	2	31561359
Pubmed	Calpain I Activation Causes GLUT3 Proteolysis and Downregulation of O-GlcNAcylation in Alzheimer's Disease Brain.	SLC2A14 SLC2A3	7.91e-06	3	57	2	29614685
Pubmed	High NOV/CCN3 expression during high-fat diet pregnancy in mice affects GLUT3 expression and the mTOR pathway.	SLC2A14 SLC2A3	7.91e-06	3	57	2	33586490
Pubmed	Hyperglycemia reduces mitochondrial content and glucose transporter expression in mouse embryos developing in vitro.	SLC2A14 SLC2A3	7.91e-06	3	57	2	19550108
Pubmed	LPCAT1 Facilitates Keratinocyte Hyperproliferation and Skin Inflammation in Psoriasis by Regulating GLUT3.	SLC2A14 SLC2A3	7.91e-06	3	57	2	38246582
Pubmed	Placental glucose transporter expression is regulated by glucocorticoids.	SLC2A14 SLC2A3	7.91e-06	3	57	2	10199793
Pubmed	Glucose transporter GLUT3: ontogeny, targeting, and role in the mouse blastocyst.	SLC2A14 SLC2A3	7.91e-06	3	57	2	9108057
Pubmed	Glucose transporter proteins in brain.	SLC2A14 SLC2A3	7.91e-06	3	57	2	7926364
Pubmed	Recurrent moderate hypoglycemia accelerates the progression of Alzheimer's disease through impairment of the TRPC6/GLUT3 pathway.	SLC2A14 SLC2A3	7.91e-06	3	57	2	35077394
Pubmed	Molecular cloning of murine homologue dentatorubral-pallidoluysian atrophy (DRPLA) cDNA: strong conservation of a polymorphic CAG repeat in the murine gene.	SLC2A14 SLC2A3	7.91e-06	3	57	2	9070948
Pubmed	Significant reduction of the GLUT3 level, but not GLUT1 level, was observed in the brain tissues of several scrapie experimental animals and scrapie-infected cell lines.	SLC2A14 SLC2A3	7.91e-06	3	57	2	24243341
Pubmed	Vitamin C enters mouse T cells as dehydroascorbic acid in vitro and does not recapitulate in vivo vitamin C effects.	SLC2A14 SLC2A3	7.91e-06	3	57	2	19327547
Pubmed	Glucose Metabolism Is Required for Platelet Hyperactivation in a Murine Model of Type 1 Diabetes.	SLC2A14 SLC2A3	7.91e-06	3	57	2	30765335
Pubmed	Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function.	SLC2A14 SLC2A3	7.91e-06	3	57	2	28746873
Pubmed	Glucose transporter expression in brain. cDNA sequence of mouse GLUT3, the brain facilitative glucose transporter isoform, and identification of sites of expression by in situ hybridization.	SLC2A14 SLC2A3	7.91e-06	3	57	2	1730609
Pubmed	Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues.	SLC2A14 SLC2A3	7.91e-06	3	57	2	3170580
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FASN SLC38A10 LLGL2 ZFP36L2 CSPG4 AOC2 DEPDC5 PLCG1 ZZEF1 SDHA	1.12e-05	1105	57	10	35748872
Pubmed	Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.	SLC38A10 LLGL2 PPFIBP1 FLAD1 MARK2	1.28e-05	183	57	5	31932471
Pubmed	Difference in allelic expression of genes probably associated with tumor progression in murine fibrosarcomas and cell lines.	SLC2A14 SLC2A3	1.58e-05	4	57	2	7961103
Pubmed	Developmental regulation of genes mediating murine brain glucose uptake.	SLC2A14 SLC2A3	1.58e-05	4	57	2	10070152
Pubmed	Cytoprotective effects of hesperetin and hesperidin against amyloid β-induced impairment of glucose transport through downregulation of neuronal autophagy.	SLC2A14 SLC2A3	1.58e-05	4	57	2	22383310
Pubmed	Creb1-Mecp2-(m)CpG complex transactivates postnatal murine neuronal glucose transporter isoform 3 expression.	SLC2A14 SLC2A3	1.58e-05	4	57	2	23493374
Pubmed	In vitro analysis of the glucose-transport system in GLUT4-null skeletal muscle.	SLC2A14 SLC2A3	1.58e-05	4	57	2	10455018
Pubmed	Analysis of glucose metabolism by 18F-FDG-PET imaging and glucose transporter expression in a mouse model of intracerebral hemorrhage.	SLC2A14 SLC2A3	1.58e-05	4	57	2	34035344
Pubmed	Glucose transporter 3 is a rab11-dependent trafficking cargo and its transport to the cell surface is reduced in neurons of CAG140 Huntington's disease mice.	SLC2A14 SLC2A3	1.58e-05	4	57	2	25526803
Pubmed	Changes in Expression of Follicular Glucose Transporters May Be Involved in Ovarian Function Impairment during Diabetic Hyperglycemia.	SLC2A14 SLC2A3	1.58e-05	4	57	2	31882430
Pubmed	Neonatal hypothyroidism affects testicular glucose homeostasis through increased oxidative stress in prepubertal mice: effects on GLUT3, GLUT8 and Cx43.	SLC2A14 SLC2A3	1.58e-05	4	57	2	28471544
Pubmed	A Nodal enhanced micropeptide NEMEP regulates glucose uptake during mesendoderm differentiation of embryonic stem cells.	SLC2A14 SLC2A3	1.58e-05	4	57	2	35810171
Pubmed	Trans-activators regulating neuronal glucose transporter isoform-3 gene expression in mammalian neurons.	SLC2A14 SLC2A3	1.58e-05	4	57	2	15054091
Pubmed	Hypoxia regulation of facilitated glucose transporter-1 and glucose transporter-3 in mouse chondrocytes mediated by HIF-1alpha.	SLC2A14 SLC2A3	1.58e-05	4	57	2	17983831
Pubmed	Prenatal Exposure to Sodium Arsenite Alters Placental Glucose 1, 3, and 4 Transporters in Balb/c Mice.	SLC2A14 SLC2A3	1.58e-05	4	57	2	26339590
Pubmed	Endotoxin-induced enhancement of glucose influx into murine peritoneal macrophages via GLUT1.	SLC2A14 SLC2A3	1.58e-05	4	57	2	8557327
Pubmed	Glucose transporter expression and functional role of hexokinase in insulin biosynthesis in mouse beta TC3 cells.	SLC2A14 SLC2A3	1.58e-05	4	57	2	7653530
Pubmed	GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing.	SLC2A14 SLC2A3	1.58e-05	4	57	2	37721853
Pubmed	Phosphorylation of MAP2c and MAP4 by MARK kinases leads to the destabilization of microtubules in cells.	MAP2 MARK2	1.58e-05	4	57	2	10542369
Pubmed	Glucose uptake, utilization, and signaling in GLUT2-null islets.	SLC2A14 SLC2A3	1.58e-05	4	57	2	10969832
Pubmed	Developing Brain Glucose Transporters, Serotonin, Serotonin Transporter, and Oxytocin Receptor Expression in Response to Early-Life Hypocaloric and Hypercaloric Dietary, and Air Pollutant Exposures.	SLC2A14 SLC2A3	1.58e-05	4	57	2	33774619
Pubmed	Glucose utilization and glucose transporter proteins GLUT-1 and GLUT-3 in brains of diabetic (db/db) mice.	SLC2A14 SLC2A3	1.58e-05	4	57	2	9124334
Pubmed	Oxygen-regulated expression of GLUT-1, GLUT-3, and VEGF in the mouse blastocyst.	SLC2A14 SLC2A3	1.58e-05	4	57	2	15515055
Pubmed	Immunohistochemical localization and quantification of glucose transporters in the mouse brain.	SLC2A14 SLC2A3	1.58e-05	4	57	2	11955709
Pubmed	Maternal hyperglycemia alters glucose transport and utilization in mouse preimplantation embryos.	SLC2A14 SLC2A3	1.58e-05	4	57	2	9688872
Pubmed	Mutations in DEPDC5 cause familial focal epilepsy with variable foci.	MAP2 DEPDC5	2.63e-05	5	57	2	23542697
Pubmed	Hypoxic adaptation engages the CBP/CREST-induced coactivator complex of Creb-HIF-1α in transactivating murine neuroblastic glucose transporter.	SLC2A14 SLC2A3	2.63e-05	5	57	2	23321477
Pubmed	Prenatal expression of the GLUT4 glucose transporter in the mouse.	SLC2A14 SLC2A3	2.63e-05	5	57	2	10965149
Pubmed	GLUT1 Expression in Tumor-Associated Neutrophils Promotes Lung Cancer Growth and Resistance to Radiotherapy.	SLC2A14 SLC2A3	2.63e-05	5	57	2	33753374
Pubmed	Identification of a murine TEF-1-related gene expressed after mitogenic stimulation of quiescent fibroblasts and during myogenic differentiation.	SLC2A14 SLC2A3	2.63e-05	5	57	2	8662936
Pubmed	Organization of the mouse microfibril-associated glycoprotein-2 (MAGP-2) gene.	SLC2A14 SLC2A3	2.63e-05	5	57	2	10723723
Pubmed	Fatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL.	FASN RPS6KA1	2.63e-05	5	57	2	29483509
Pubmed	Developmental expression and cellular localization of glucose transporter molecules during mouse preimplantation development.	SLC2A14 SLC2A3	2.63e-05	5	57	2	1638987
Pubmed	Differential screening of a PCR-generated mouse embryo cDNA library: glucose transporters are differentially expressed in early postimplantation mouse embryos.	SLC2A14 SLC2A3	2.63e-05	5	57	2	1289053
Pubmed	Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems.	SLC2A14 SLC2A3	2.63e-05	5	57	2	16365304
Pubmed	The glucose transporter family: structure, function and tissue-specific expression.	SLC2A14 SLC2A3	2.63e-05	5	57	2	8240230
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	LLGL2 EXPH5 PPFIBP1 CSPG4 DCBLD1 MARK2 SLC2A3	3.94e-05	569	57	7	30639242
Pubmed	Molecular identification and functional characterization of the vitamin C transporters expressed by Sertoli cells.	SLC2A14 SLC2A3	3.94e-05	6	57	2	18668520
Pubmed	Polysialic acid as an antigen for monoclonal antibody HIgM12 to treat multiple sclerosis and other neurodegenerative disorders.	MAP2 CSPG4	3.94e-05	6	57	2	25866077
Pubmed	p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation.	SLC2A14 SLC2A3	3.94e-05	6	57	2	18391940
Pubmed	Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth.	SLC2A14 SLC2A3	3.94e-05	6	57	2	32571479
Pubmed	Metabolic mode peculiar to Meckel's cartilage: immunohistochemical comparisons of hypoxia-inducible factor-1alpha and glucose transporters in developing endochondral bones in mice.	SLC2A14 SLC2A3	3.94e-05	6	57	2	18705802
Pubmed	Glucose uptake mediated by glucose transporter 1 is essential for early tooth morphogenesis and size determination of murine molars.	SLC2A14 SLC2A3	3.94e-05	6	57	2	22226978
Pubmed	A novel LPS-inducible C-type lectin is a transcriptional target of NF-IL6 in macrophages.	SLC2A14 SLC2A3	3.94e-05	6	57	2	10528209
Pubmed	Assignment of a novel protein tyrosine phosphatase gene (Hcph) to mouse chromosome 6.	SLC2A14 SLC2A3	3.94e-05	6	57	2	1427910
Pubmed	Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue.	SLC2A14 SLC2A3 OPLAH	3.95e-05	40	57	3	27760309
Pubmed	Characterization of genes which exhibit reduced expression during the retinoic acid-induced differentiation of F9 teratocarcinoma cells: involvement of cyclin D3 in RA-mediated growth arrest.	SLC2A14 SLC2A3	5.51e-05	7	57	2	9806360
Pubmed	Identification of putative downstream genes of Oct-3, a pluripotent cell-specific transcription factor.	SLC2A14 SLC2A3	5.51e-05	7	57	2	9140067
Pubmed	Essential role of glucose transporter GLUT3 for post-implantation embryonic development.	SLC2A14 SLC2A3	5.51e-05	7	57	2	18948350
Pubmed	Identification of NPM-ALK interacting proteins by tandem mass spectrometry.	MEP1B PLCG1 MAP3K4	6.43e-05	47	57	3	14968112
Pubmed	ROR2 Downregulation Activates the MSX2/NSUN2/p21 Regulatory Axis and Promotes Dental Pulp Stem Cell Senescence.	CNBP MYH6 MAP2 RPS24	6.51e-05	131	57	4	35356984
Pubmed	Acetoacetyl-CoA synthetase is essential for normal neuronal development.	FASN MAP2	7.34e-05	8	57	2	23000407
Pubmed	Altered placental function of 11beta-hydroxysteroid dehydrogenase 2 knockout mice.	SLC2A14 SLC2A3	9.43e-05	9	57	2	18845627
Pubmed	The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming.	SLC2A14 SLC2A3	9.43e-05	9	57	2	35316657
Pubmed	GLUT1 is redundant in hypoxic and glycolytic nucleus pulposus cells of the intervertebral disc.	SLC2A14 SLC2A3	9.43e-05	9	57	2	36917198
Pubmed	Lmx1b, Pet-1, and Nkx2.2 coordinately specify serotonergic neurotransmitter phenotype.	SLC2A14 SLC2A3	9.43e-05	9	57	2	14602809
Pubmed	A systematic analysis of a deep mouse epididymal sperm proteome.	SLC2A14 SLC2A3	1.18e-04	10	57	2	23115268
Pubmed	Prolonged endoplasmic reticulum stress alters placental morphology and causes low birth weight.	SLC2A14 SLC2A3	1.18e-04	10	57	2	24370435
Pubmed	Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development.	SLC2A14 SLC2A3	1.18e-04	10	57	2	18194653
Interaction	BPNT2 interactions	PTPRN VIRMA SDHA TCTN2	1.52e-05	56	54	4	int:BPNT2
Interaction	SLC2A14 interactions	SLC2A14 SLC2A3 SDHA	1.71e-05	19	54	3	int:SLC2A14
Cytoband	Ensembl 112 genes in cytogenetic band chr2q35	PTPRN ABCA12 DNAJB2	5.68e-04	129	57	3	chr2q35
Cytoband	Ensembl 112 genes in cytogenetic band chr17q25	FASN SLC38A10 LLGL2 MYADML2	5.86e-04	307	57	4	chr17q25
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	FBLN7 C2 CSMD1	1.97e-04	57	36	3	1179
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LLGL2 MAP2 MTHFD2L CACNA2D3 FBXL4	4.35e-06	189	57	5	e059be2965cca70ff5576df055d0af1775b76e00
ToppCell	PND01-03-samps-Mesenchymal-Pericyte\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	ART3 MAP2 CSPG4 FGF22	4.30e-05	152	57	4	fc9472bc19f997103da535b035105f01429cb08e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GPR20 PTPRN CSPG4 CSMD1	5.78e-05	164	57	4	43630a448f4369fa9e4e3eccdf3b9f29cec16c39
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GPR20 PTPRN CSPG4 CSMD1	5.78e-05	164	57	4	108fbecb56d69a675d6ce6e826a873ae528f2fd7
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GPR20 PTPRN CSPG4 CSMD1	5.78e-05	164	57	4	46208f18325976c89f572f6627aea0582142b92d
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GPLD1 PTPRN MYADML2 RIPPLY3	6.65e-05	170	57	4	941d637cf76918ee4b0a1833abd1a42593cb8b1a
ToppCell	wk_20-22-Mesenchymal-Chondrocyte\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	ART3 MAP2 CSPG4 AOC2	6.80e-05	171	57	4	d2938639e9a7c349e5a6ec61724222f9d127c89f
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYH6 ART3 CSPG4 AGBL5	7.60e-05	176	57	4	4ed73c73972334f6dc4229920205547823252fa0
ToppCell	3'-Adult-LargeIntestine-Hematopoietic-T_cells-Treg\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FBLN7 PIM2 SLC2A14 SLC2A3	7.94e-05	178	57	4	307b6e21bc69a0310c550f1fafa8600285e99ccd
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GPR20 ART3 MAP2 CSPG4	8.12e-05	179	57	4	56db12467b445f2b8ef92af50779eeab10413eb2
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZDHHC2 ART3 CSPG4 CSMD1	8.66e-05	182	57	4	a1c0e4090a9e7aa4941a40c817d178de144888b6
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1\|Children_(3_yrs) / Lineage, Cell type, age group and donor	LLGL2 MAP2 PPFIBP1 CACNA2D3	9.22e-05	185	57	4	1c222f7285d6e3dae0354dc7e853ddc0ea55e63e
ToppCell	Fetal_29-31_weeks-Mesenchymal-chondrocyte-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FBLN7 ART3 CSPG4 CACNA2D3	9.22e-05	185	57	4	8ed10ba581849c9c4ac4397226be2b62b4b3b900
ToppCell	Fetal_29-31_weeks-Mesenchymal-chondrocyte\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FBLN7 ART3 CSPG4 CACNA2D3	9.22e-05	185	57	4	b8052cebb73f41abe6faf0aa847be7c8ef23ae94
ToppCell	droplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l30\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FBLN7 ART3 CSPG4 CSMD1	9.61e-05	187	57	4	6f7f293c9cf35261e0e3614e46ec1fb00a701b63
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1\|Adult / Lineage, Cell type, age group and donor	LLGL2 MAP2 PPFIBP1 CACNA2D3	9.61e-05	187	57	4	77f78aec946bc6bd85c29aee9ca978ce49f853a3
ToppCell	facs-Trachea-nan-3m-Mesenchymal-smooth_muscle_cell_of_trachea\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR20 ART3 MAP2 CSMD1	9.81e-05	188	57	4	794fc1d9a726945c42f7eac221eed938309b47a9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GPR20 MAP2 CSPG4 CSMD1	1.00e-04	189	57	4	7fbe855bfdb47d35e040b04a80fe4b729a3764e8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GPR20 MAP2 CSPG4 CSMD1	1.00e-04	189	57	4	06b35abecd29f902cf251fcc1f6ad33db7ab08a2
ToppCell	(0)_T_CD4\|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)	FBLN7 PIM2 ZFP36L2 SLC2A3	1.04e-04	191	57	4	ba289658777a2669fda9da9128e87adb60fd8430
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.4.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FASN C2 RPS24 AGBL5	1.04e-04	191	57	4	2b0d55a8e1b4ce862dd038f8e0429e8428fb8aba
ToppCell	facs-Lung-3m-Mesenchymal-myofibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ART3 CSPG4 CSMD1 CACNA2D3	1.04e-04	191	57	4	fd8331c7abdd999f55ba43d307945c6abfccbf84
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ART3 MAP2 ZFP36L2 RPS24	1.06e-04	192	57	4	d0649410cf5eacdb0c1dce70e37c7473ef5fddfa
ToppCell	(1)_T_cells-(1)_T_CD4\|(1)_T_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	FBLN7 PIM2 ZFP36L2 SLC2A3	1.09e-04	193	57	4	788daf1d7c7a26eb052b386a114248772e05c27e
ToppCell	droplet-Lung-3m-Mesenchymal-myofibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ART3 CSPG4 CSMD1 CACNA2D3	1.11e-04	194	57	4	c992e3357f4bf3069f8d697803e5785e49a2ef0a
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)\|10x_3'_v3 / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	FBLN7 PIM2 ZFP36L2 PLCG1	1.11e-04	194	57	4	1600ed112cec4ad05469b4aa5647314a8691575c
ToppCell	critical-Lymphoid-Treg\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	FBLN7 PIM2 ZFP36L2 SLC2A3	1.15e-04	196	57	4	861665912eb0538b083d3eee77190925b3a43c24
ToppCell	10x5'-Liver-Lymphocytic_T_CD4\|Liver / Manually curated celltypes from each tissue	FBLN7 ZFP36L2 PLCG1 SLC2A3	1.17e-04	197	57	4	4891111894b741555f549deec6af8006376d9358
ToppCell	Severe_COVID-19-T/NK-CD4+_T_1\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	FBLN7 PIM2 ZFP36L2 PLCG1	1.20e-04	198	57	4	bc6b983fdb9547ef8a9e693bc15fced1b73e101f
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell-CD4_T_cells-CD4_T_cells_L.1.1.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FBLN7 PIM2 ZFP36L2 SLC2A3	1.20e-04	198	57	4	f6472649cf000918b98126cf02821d6779643292
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FBLN7 PIM2 ZFP36L2 PLCG1	1.20e-04	198	57	4	fc8099bce80d84b29bdcc87064d4d8375dddfa0f
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_1\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	FBLN7 PIM2 ZFP36L2 PLCG1	1.20e-04	198	57	4	32ec322ed144c545014b191da5274d12feeaf96b
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-T_lymphocytic\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	FBLN7 ZFP36L2 PLCG1 SLC2A3	1.20e-04	198	57	4	db107a5511571384f26e26c6301aef9a9f2423c4
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell-CD4_T_cells\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FBLN7 PIM2 ZFP36L2 SLC2A3	1.20e-04	198	57	4	cd1cd0ac2a66578aa38a139322295170002ec049
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_1-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FBLN7 PIM2 ZFP36L2 PLCG1	1.20e-04	198	57	4	1e281d8f0291e8cf814e9e5abd7f5860402a7c77
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FBLN7 PIM2 ZFP36L2 SLC2A3	1.20e-04	198	57	4	a17eb0e19e04e9d4fe14e19452d79c3c4559817a
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FBLN7 PIM2 ZFP36L2 PLCG1	1.20e-04	198	57	4	74f190d8e337cff5ffb65d446cf784759e1c2a59
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD4+_T\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	FBLN7 PIM2 ZFP36L2 PLCG1	1.22e-04	199	57	4	4669b6be3b513d80b6f79bd10a1974fefdf58093
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD4+_T\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FBLN7 PIM2 ZFP36L2 PLCG1	1.22e-04	199	57	4	b270d8274249103d3a1b4a4f8601c92fde007ed7
ToppCell	FLU-Healthy-4\|Healthy / Virus stimulation, Condition and Cluster	ZFP36L2 RPS24 DNAJB2 SLC2A3	1.22e-04	199	57	4	40061131e35131873192ca65c0e731a7b3045636
ToppCell	ILEUM-inflamed-(3)_MNP-(3)_DC2\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	ZFP36L2 RPS24 EIF3G CACNA2D3	1.22e-04	199	57	4	64b320a9e4e65071cff77980dbff7e06526819b3
ToppCell	10x5'-Lung-Lymphocytic_T_CD4\|Lung / Manually curated celltypes from each tissue	FBLN7 PIM2 ZFP36L2 PLCG1	1.22e-04	199	57	4	32b9f19579448f1775ecb7974c29c60334513c88
ToppCell	18-Airway-Mesenchymal-Cartilage\|Airway / Age, Tissue, Lineage and Cell class	FBLN7 ART3 CSPG4 RPS24	1.22e-04	199	57	4	f5d0aa4170367c080d3c2f01d9af3529762917fa
ToppCell	COVID-19-Lymphoid-CD4_T_cells\|COVID-19 / Condition, Lineage and Cell class	FBLN7 PIM2 ZFP36L2 PLCG1	1.22e-04	199	57	4	27ac7ad2f4c2028c355632cbb81f2b52439b85ad
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-CD8_EM\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FBLN7 PIM2 ZFP36L2 SLC2A3	1.24e-04	200	57	4	712e3b7c12308b547cfe362b46a6313236391667
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-CD8_EM-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FBLN7 PIM2 ZFP36L2 SLC2A3	1.24e-04	200	57	4	55f19f990fa02664aa02812f6fc65f93d5e7f382
ToppCell	Sepsis-ICU-NoSEP\|Sepsis / Disease, condition lineage and cell class	CNBP ZFP36L2 RPS24 EIF3G	1.24e-04	200	57	4	173b74bd83c5018035ec73f33896d4058a2fff87
Drug	lysosphingomyelin	GPLD1 CDR1 ART3 RPS6KA1 PLCG1 MAP3K4	2.66e-06	160	56	6	CID000005263
Drug	Ketoprofen [22071-15-4]; Down 200; 15.8uM; MCF7; HT_HG-U133A	GPLD1 ZFP36L2 PPFIBP1 DEPDC5 MARK2 CAPN15	9.07e-06	198	56	6	3626_DN
Drug	CTK2I5299	CNBP ART3 CSPG4 MARK2	1.02e-05	55	56	4	CID005310955
Drug	LY294002	CNBP GPLD1 MYH6 FASN ART3 RPS6KA1 SLC2A14 PLCG1 MARK2 SLC2A3	1.25e-05	748	56	10	CID000003973
Disease	Cardiomyopathy, Dilated	MYH6 FASN SDHA	1.05e-04	48	56	3	C0007193
Disease	Cardiomyopathy, Familial Idiopathic	MYH6 FASN SDHA	1.19e-04	50	56	3	C1449563
Disease	cataract (biomarker_via_orthology)	SLC2A14 SLC2A3	2.72e-04	13	56	2	DOID:83 (biomarker_via_orthology)
Disease	insulin metabolic clearance rate measurement, glucose homeostasis measurement	RPS6KA1 ZZEF1	3.17e-04	14	56	2	EFO_0006830, EFO_0006896
Disease	Hypertrophic obstructive cardiomyopathy	MYH6 FASN	1.03e-03	25	56	2	C4551472
Disease	Sezary Syndrome	RPS6KA1 PLCG1	1.20e-03	27	56	2	C0036920
Disease	Primary familial dilated cardiomyopathy	MYH6 SDHA	1.49e-03	30	56	2	cv:C0340427
Disease	response to vaccine	C2 CSMD1 CACNA2D3	1.63e-03	122	56	3	EFO_0004645

Protein segments in the cluster

Peptide	Gene	Start	Entry
HRFVEGRGATTFFAF	AGBL5	141	Q8NDL9
TGQSKGFAFISFHRR	EIF3G	276	O75821
RIGFHFGVGDSLTFS	CSMD1	1056	Q96PZ7
FSHRGTLDGGFRFRL	CSPG4	1546	Q6UVK1
GSLQHIKSRFGRGFT	ABCA12	2471	Q86UK0
TSGFQATVRGLFGQH	GPR20	301	Q99678
FSGRHGFFGRRRFSG	CDR1	141	P51861
LVFRATFGSGGHLSL	CAPN15	851	O75808
FTFGHGVFSGLRIFD	AOC2	331	O75106
RHSSFSRSFGGRSQA	DEPDC5	1326	O75140
LRFGIVGGNSRGHFV	FBLN7	371	Q53RD9
FHQFGSRDGSRVSEG	PTPRN	211	Q16849
TFSLVAHRGGFAGVQ	MYADML2	36	A6NDP7
RLVAFGTSHGFGLFD	LLGL2	601	Q6P1M3
FREDFHSGRGGFGRQ	NCBP2L	136	A6PVI3
FGTRKVRSSFGRGFF	PPFIBP1	516	Q86W92
ISLGAVRTGFRFGHG	C2	156	P06681
RADQHTFGSKGAFGF	RIPPLY3	61	P57055
FFSNTFGRSGEQRRF	EXPH5	461	Q8NEV8
FSSTHFFLRVDPGGR	FGF22	46	Q9HCT0
GSFSVGLFVNRFGRR	SLC2A14	101	Q8TDB8
QHSFTRGFSGVLGFR	PKD1L2	1981	Q7Z442
SRGHGKYFFRGNVTI	CACNA2D3	621	Q8IZS8
GNRGFISVAGFSRFL	FBXL4	356	Q9UKA2
LQNRGSRHSGPFFTF	DNAJB2	126	P25686
FSESGEGTRFLHGAR	IDI2-AS1	66	Q9NZ38
NFPRGVSSRSTFHAG	MARK2	586	Q7KZI7
IGSFSVGLFVNRFGR	SLC2A3	76	P11169
RFESGSHISGRGFLL	DCBLD1	131	Q8N8Z6
NSFGFGGSNVHIILR	FASN	391	P49327
FSNRFTHVLTAGGIG	FLAD1	166	Q8NFF5
KRRDGTGGVTGHFTF	PSG4	126	Q00888
GFGELFRTHFFLNAG	SAMM50	386	Q9Y512
FFARLFGFQVGGTFR	SLC38A10	111	Q9HBR0
FRRGGGYGTSAFITH	MEP1B	551	Q16820
GSFAFVRDRAGFNGT	MAP3K4	306	Q9Y6R4
TAGFSGIFSNFLFRR	TMEM126B	81	Q8IUX1
LQTGTRGFHFTVDGN	SDHA	26	P31040
GRFHFAIDRGGTFTD	OPLAH	6	O14841
GGSRLFFRSGLFVVG	OPLAH	356	O14841
GGFGTVFAGHRLTDR	PIM2	41	Q9P1W9
NSSRFGKFIRIHFGA	MYH6	241	P13533
THQSGAFGSVFGSRA	POM121L2	871	Q96KW2
SRGRGGFTSDRGFQF	CNBP	31	P62633
FVFGFRTHFGGGKTT	RPS24	56	P62847
GDRRFSRFGGVLHLS	GPLD1	711	P80108
GRFSGRHHFVAGRFV	YJEFN3	261	A6XGL0
SGQLFHGRAREGSFE	PLCG1	1236	P19174
GSAFRGFRSSGVRHE	MTHFD2L	36	Q9H903
SIALGFNFGRGHDLS	MAP2	711	P11137
LGFRGSGQRARHNSF	nan	86	Q6ZRN7
RFTVTAGHLGRFQTG	ZZEF1	2791	O43149
SIFFGNFRGNRIHFS	SLC9C2	196	Q5TAH2
FRHGTDKNGFSLGFS	ZDHHC2	251	Q9UIJ5
SGFAPGFLRRHSASN	ZFP36L2	46	P47974
FVSGGSGRGRHVRSF	VIRMA	1796	Q69YN4
TLFRRSCFTGVFGGD	TCTN2	196	Q96GX1
GAHQLFRGFSFVATG	RPS6KA1	371	Q15418
TFGGLNQARFGHFTL	ART3	171	Q13508