Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cadmium ion transmembrane transporter activity	SLC11A2 SLC11A1	1.49e-05	3	45	2	GO:0015086
GeneOntologyMolecularFunction	manganese ion transmembrane transporter activity	SLC11A2 SLC11A1	2.21e-04	10	45	2	GO:0005384
GeneOntologyMolecularFunction	iron ion transmembrane transporter activity	SLC11A2 SLC11A1	2.70e-04	11	45	2	GO:0005381
GeneOntologyMolecularFunction	microtubule motor activity	KIF9 KIF15 KIF25	5.27e-04	70	45	3	GO:0003777
GeneOntologyMolecularFunction	neurexin family protein binding	NLGN2 SYTL4	5.84e-04	16	45	2	GO:0042043
GeneOntologyMolecularFunction	mRNA 3'-UTR AU-rich region binding	ELAVL1 ELAVL3	1.94e-03	29	45	2	GO:0035925
GeneOntologyMolecularFunction	cytoskeletal motor activity	KIF9 KIF15 KIF25	2.38e-03	118	45	3	GO:0003774
GeneOntologyMolecularFunction	palmitoyltransferase activity	SPTLC2 CPT1C	3.15e-03	37	45	2	GO:0016409
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC11A2 SLC11A1 SLC34A1 SLC18B1	4.37e-03	296	45	4	GO:0015291
GeneOntologyMolecularFunction	transition metal ion transmembrane transporter activity	SLC11A2 SLC11A1	4.42e-03	44	45	2	GO:0046915
GeneOntologyMolecularFunction	active monoatomic ion transmembrane transporter activity	SLC11A2 SLC11A1 SLC34A1 SLC18B1	4.64e-03	301	45	4	GO:0022853
GeneOntologyBiologicalProcess	cadmium ion transmembrane transport	SLC11A2 SLC11A1	6.64e-05	6	44	2	GO:0070574
GeneOntologyBiologicalProcess	cadmium ion transport	SLC11A2 SLC11A1	6.64e-05	6	44	2	GO:0015691
GeneOntologyCellularComponent	kinesin complex	KIF9 KIF15 KIF25	1.60e-04	49	45	3	GO:0005871
Domain	Nramp	SLC11A2 SLC11A1	5.42e-06	2	44	2	PF01566
Domain	NRAMP_fam	SLC11A2 SLC11A1	5.42e-06	2	44	2	IPR001046
Domain	ELAD_HUD_SF	ELAVL1 ELAVL3	3.24e-05	4	44	2	IPR006548
Domain	Kinesin-like_fam	KIF9 KIF15 KIF25	1.41e-04	43	44	3	IPR027640
Domain	KINESIN_MOTOR_1	KIF9 KIF15 KIF25	1.51e-04	44	44	3	PS00411
Domain	-	KIF9 KIF15 KIF25	1.51e-04	44	44	3	3.40.850.10
Domain	Kinesin_motor_dom	KIF9 KIF15 KIF25	1.51e-04	44	44	3	IPR001752
Domain	Kinesin	KIF9 KIF15 KIF25	1.51e-04	44	44	3	PF00225
Domain	KISc	KIF9 KIF15 KIF25	1.51e-04	44	44	3	SM00129
Domain	KINESIN_MOTOR_2	KIF9 KIF15 KIF25	1.51e-04	44	44	3	PS50067
Domain	Hud_Sxl_RNA	ELAVL1 ELAVL3	2.41e-04	10	44	2	IPR002343
Domain	-	SEPSECS SPTLC2	3.80e-03	39	44	2	3.40.640.10
Domain	Kinesin_motor_CS	KIF9 KIF25	4.20e-03	41	44	2	IPR019821
Domain	PyrdxlP-dep_Trfase	SEPSECS SPTLC2	4.20e-03	41	44	2	IPR015424
Domain	PyrdxlP-dep_Trfase_major_sub1	SEPSECS SPTLC2	4.20e-03	41	44	2	IPR015421
Pubmed	Nramp1: a link between intracellular iron transport and innate resistance to intracellular pathogens.	SLC11A2 SLC11A1	1.64e-06	2	45	2	10577506
Pubmed	RNA-binding protein HuR is required for stabilization of SLC11A1 mRNA and SLC11A1 protein expression.	ELAVL1 SLC11A1	1.64e-06	2	45	2	16135804
Pubmed	Identification of a tyrosine-based motif (YGSI) in the amino terminus of Nramp1 (Slc11a1) that is important for lysosomal targeting.	SLC11A2 SLC11A1	1.64e-06	2	45	2	16905747
Pubmed	Cloning and characterization of a second human NRAMP gene on chromosome 12q13.	SLC11A2 SLC11A1	1.64e-06	2	45	2	7613023
Pubmed	Analysis of the RNA recognition motifs of human neuronal ELAV-like proteins in binding to a cytokine mRNA.	ELAVL1 ELAVL3	1.64e-06	2	45	2	10079173
Pubmed	SLC11A1 (NRAMP1) but not SLC11A2 (NRAMP2) polymorphisms are associated with susceptibility to tuberculosis in a high-incidence community in South Africa.	SLC11A2 SLC11A1	1.64e-06	2	45	2	15636493
Pubmed	Mutation analysis of seven SLC family transporters for early-onset Parkinson's disease in Chinese population.	SLC11A2 SLC11A1	1.64e-06	2	45	2	33781609
Pubmed	Nutritional immunity: homology modeling of Nramp metal import.	SLC11A2 SLC11A1	1.64e-06	2	45	2	21948377
Pubmed	Both Nramp1 and DMT1 are necessary for efficient macrophage iron recycling.	SLC11A2 SLC11A1	1.64e-06	2	45	2	20394798
Pubmed	Evolution of differences in transport function in Slc11a family members.	SLC11A2 SLC11A1	1.64e-06	2	45	2	17932044
Pubmed	Identification and characterization of a second mouse Nramp gene.	SLC11A2 SLC11A1	1.64e-06	2	45	2	7789986
Pubmed	Candidate gene association study of solute carrier family 11a members 1 (SLC11A1) and 2 (SLC11A2) genes in Alzheimer's disease.	SLC11A2 SLC11A1	4.91e-06	3	45	2	15644277
Pubmed	Diversity of Ca2+-activated K+ channel transcripts in inner ear hair cells.	SLC11A2 SLC11A1	4.91e-06	3	45	2	17097837
Pubmed	HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA.	ELAVL1 ELAVL3	9.81e-06	4	45	2	10848602
Pubmed	Hu proteins regulate alternative splicing by inducing localized histone hyperacetylation in an RNA-dependent manner.	ELAVL1 ELAVL3	9.81e-06	4	45	2	21808035
Pubmed	Role for a novel Usher protein complex in hair cell synaptic maturation.	ADGRV1 CLRN1	9.81e-06	4	45	2	22363448
Pubmed	Defining the membrane proteome of NK cells.	DIP2B ELAVL1 PSMD2 C1QTNF3 DNAJC13 SLC11A2 GALNT1 HYOU1 KIF15	1.57e-05	1168	45	9	19946888
Pubmed	A hierarchy of Hu RNA binding proteins in developing and adult neurons.	ELAVL1 ELAVL3	2.45e-05	6	45	2	9096138
Pubmed	Biochemical characterization of native Usher protein complexes from a vesicular subfraction of tracheal epithelial cells.	ADGRV1 CLRN1	3.42e-05	7	45	2	20058854
Pubmed	Stabilization of Dll1 mRNA by Elavl1/HuR in neuroepithelial cells undergoing mitosis.	ELAVL1 ELAVL3	3.42e-05	7	45	2	21346194
Pubmed	Microarray-based mutation analysis of 183 Spanish families with Usher syndrome.	ADGRV1 CLRN1	4.56e-05	8	45	2	19683999
Pubmed	Massively parallel DNA sequencing facilitates diagnosis of patients with Usher syndrome type 1.	ADGRV1 CLRN1	7.32e-05	10	45	2	24618850
Pubmed	Usher protein functions in hair cells and photoreceptors.	ADGRV1 CLRN1	7.32e-05	10	45	2	24239741
Pubmed	Organization and evolutionary relatedness of OR37 olfactory receptor genes in mouse and human.	OR13C3 OR13C4	1.07e-04	12	45	2	12906860
Pubmed	Sequence and expression of murine type I hair keratins mHa2 and mHa3.	KIF9 KIF15	1.47e-04	14	45	2	7514534
Pubmed	An oocyte-specific ELAVL2 isoform is a translational repressor ablated from meiotically competent antral oocytes.	ELAVL1 ELAVL3	1.47e-04	14	45	2	24553115
Pubmed	Candidate genes and their regulatory elements: alcohol preference and tolerance.	GALNT1 HYOU1	2.20e-04	17	45	2	16783646
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DIP2B ELAVL1 ELAVL3 NLGN2 DNAJC13 KIF15 SEC23A	2.21e-04	963	45	7	28671696
Pubmed	Proteomic analysis of SARS-CoV-2 particles unveils a key role of G3BP proteins in viral assembly.	PSMD2 ITGA3 SEC23A	2.42e-04	93	45	3	38245532
Pubmed	Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome.	KIF9 KIF15	4.82e-04	25	45	2	9275178
Pubmed	A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney.	ITGA3 SLC34A1	5.22e-04	26	45	2	19060336
Pubmed	Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.	ITGA3 GALNT1 HYOU1 PHIP	6.59e-04	306	45	4	18973680
Pubmed	EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired.	RNF121 HYOU1 RNF139	9.77e-04	150	45	3	32423001
Pubmed	Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens.	ELAVL1 ELAVL3	1.00e-03	36	45	2	9344654
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	DIP2B ELAVL1 PSMD2 SEC23A	1.02e-03	344	45	4	30333137
Pubmed	All kinesin superfamily protein, KIF, genes in mouse and human.	KIF15 KIF25	1.06e-03	37	45	2	11416179
Pubmed	Defining the molecular character of the developing and adult kidney podocyte.	ITGA3 PLEKHH2	1.18e-03	39	45	2	21931791
Pubmed	A novel lncRNA MDHDH suppresses glioblastoma multiforme by acting as a scaffold for MDH2 and PSMA1 to regulate NAD+ metabolism and autophagy.	ELAVL1 ITGA3	1.24e-03	40	45	2	36527092
Pubmed	O-glycosylation modulates integrin and FGF signalling by influencing the secretion of basement membrane components.	GALNT1 SEC23A	1.24e-03	40	45	2	22643896
Cytoband	9q31.1	OR13C3 OR13C4	7.52e-04	41	45	2	9q31.1
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIF9 KIF15 KIF25	6.59e-05	46	31	3	622
GeneFamily	Solute carriers	SLC11A2 SLC11A1 SLC16A6 SLC34A1 SLC18B1	5.16e-04	395	31	5	752
GeneFamily	Olfactory receptors, family 13	OR13C3 OR13C4	7.04e-04	23	31	2	162
Disease	creatinine measurement	TMEM131L PSMD2 DNAJC13 ADGRV1 PLEKHH2 CMAHP SLC34A1 CASZ1	9.79e-05	995	44	8	EFO_0004518
Disease	platelet component distribution width	TMEM131L PSMD2 KIF9 BTBD2 AGBL2 TUBD1 SYTL4	1.17e-04	755	44	7	EFO_0007984
Disease	middle temporal gyrus volume measurement	OR13C3 OR13C4	1.19e-04	11	44	2	EFO_0010316
Disease	Varicose veins	DIP2B PSMD2 ADGRV1 CASZ1	1.96e-04	193	44	4	HP_0002619
Disease	total iron binding capacity	DNAJC13 CMAHP SLC34A1	2.18e-04	78	44	3	EFO_0006334
Disease	pappalysin‐1 measurement	PSMD2 UROC1	8.60e-04	29	44	2	EFO_0010618
Disease	resting heart rate, chronic obstructive pulmonary disease	ADGRV1 CASZ1	9.21e-04	30	44	2	EFO_0000341, EFO_0004351

Protein segments in the cluster

Peptide	Gene	Start	Entry
DYAASTMTEFLGMFG	CASZ1	176	Q86V15
GTYGMVMVTFEVEGG	ADGRV1	176	Q8WXG9
GFGFVTMTNYDEAAM	ELAVL3	326	Q14576
GCAVQMFFGFAMGST	OR13C4	96	Q8NGS5
FAYGQTGSGKTFTMM	KIF15	106	Q9NS87
GMMEFSLFGISYTGA	MGAM	2436	O43451
LQSFFGGTVMGESGM	ITGA3	771	P26006
EICVSSRTGGMMYFG	DIP2B	751	Q9P265
SRTGGMMYFGLAGVT	DIP2B	756	Q9P265
TMTGTYAGQFVMEGF	SLC11A1	376	P49279
STMTGTYSGQFVMEG	SLC11A2	386	P49281
GFGFVTMTNYEEAAM	ELAVL1	286	Q15717
GAGKTYTMMGATENY	KIF9	96	Q9HAQ2
TVVGMFYGAATFMYV	OR2AG1	246	Q9H205
SLMTFGGYQDDFMVV	PLEKHH2	1396	Q8IVE3
TGYFAMVVGASMTFV	SLC34A1	401	Q06495
GAPVSGVYFFTFSMM	C1QTNF3	156	Q9BXJ4
GYGVSYIFMGDGMIT	CPT1C	716	Q8TCG5
FEYMAGSDMTYGGFN	GALNT1	246	Q10472
QNIMFYDMGSGSTVC	HYOU1	226	Q9Y4L1
MGILNSYTMESTFGG	AGBL2	621	Q5U5Z8
LSGVFFFIMMYTGSN	DNAJC13	1121	O75165
SSFEVYCDMETMGGG	FGL2	236	Q14314
VGSAVFDAMFNGGMA	BTBD2	141	Q9BX70
GSYMEGTGNMFDGSV	NLGN2	186	Q8NFZ4
GCAVQMFFGFAMGST	OR13C3	126	Q8NGS6
MSCSIFFGFMVGTIG	SLC16A6	386	O15403
GVVMFGNGAYTMMFE	RNF139	476	Q8WU17
GNGAYTMMFESGSKI	RNF139	481	Q8WU17
MMSIYSEAGDFGNIF	SYTL4	341	Q96C24
FGTDMQMINFTTGEF	TMEM131L	641	A2VDJ0
FMFVAGMFVSGGVTI	SLC18B1	101	Q6NT16
VSYNSIFAMGMVGSG	PSMD2	721	Q13200
VMAYGQTGSGKSYTM	KIF25	61	Q9UIL4
LTGGYMVMGDSFNTS	SEC23A	366	Q15436
AMDFGVGGFVFGSAM	PIGW	166	Q7Z7B1
VALMMSDFAGGASGF	CMAHP	196	Q9Y471
LTMVGTAFFMYNAFG	CLRN1	111	P58418
DSFSGFFIIMSMAGG	TUBD1	131	Q9UJT1
LVFGFMFTVSGMKGE	TMEM215	21	Q68D42
GVQMICSSFSAGGMF	PHIP	321	Q8WWQ0
FLGVEAAMAYGMGFA	SPTLC2	226	O15270
ALGVTMYGQMTAGSY	UROC1	196	Q96N76
SYATGIVGYMAVMFT	RNF121	146	Q9H920
FMKGVFTFVTGTGMA	TMEM141	31	Q96I45
FTFVTGTGMAFGLQM	TMEM141	36	Q96I45
MQTVSGYTFRGFMSH	SEPSECS	411	Q9HD40
DEMAAVMGFSGFGST	ZMAT2	181	Q96NC0