Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	cyclic purine nucleotide metabolic process	PDE8A PDE8B GUCY2D ADCY9	2.29e-05	44	78	4	GO:0052652
GeneOntologyBiologicalProcess	cyclic nucleotide metabolic process	PDE8A PDE8B GUCY2D ADCY9	2.51e-05	45	78	4	GO:0009187
Domain	PDEase_PDE8	PDE8A PDE8B	1.55e-05	2	74	2	IPR013938
Domain	ARM-type_fold	TRPC4AP HEATR9 ARFGEF1 PUM2 NCBP1 TAF2 CTNNB1 LYST	5.77e-05	339	74	8	IPR016024
Domain	RasGEFN	RAPGEF6 RASGRF1 RASGRF2	6.48e-05	20	74	3	SM00229
Domain	RasGEF_N	RAPGEF6 RASGRF1 RASGRF2	7.54e-05	21	74	3	PF00618
Domain	Ras-like_Gua-exchang_fac_N	RAPGEF6 RASGRF1 RASGRF2	8.71e-05	22	74	3	IPR000651
Domain	RASGEF_NTER	RAPGEF6 RASGRF1 RASGRF2	8.71e-05	22	74	3	PS50212
Domain	RASGEF_CAT	RAPGEF6 RASGRF1 RASGRF2	2.03e-04	29	74	3	PS50009
Domain	RasGEF	RAPGEF6 RASGRF1 RASGRF2	2.24e-04	30	74	3	PF00617
Domain	-	RAPGEF6 RASGRF1 RASGRF2	2.24e-04	30	74	3	1.10.840.10
Domain	Ras_GEF_dom	RAPGEF6 RASGRF1 RASGRF2	2.24e-04	30	74	3	IPR023578
Domain	RASGEF_cat_dom	RAPGEF6 RASGRF1 RASGRF2	2.24e-04	30	74	3	IPR001895
Domain	RasGEF	RAPGEF6 RASGRF1 RASGRF2	2.24e-04	30	74	3	SM00147
Domain	PInositol-4-P-5-kinase	PIP5K1A PIP5K1C	3.21e-04	7	74	2	IPR023610
Domain	PTPc	PTPN14 PTPRB PTPRS	3.88e-04	36	74	3	SM00194
Domain	PIPKc	PIP5K1A PIP5K1C	4.27e-04	8	74	2	SM00330
Domain	-	PIP5K1A PIP5K1C	4.27e-04	8	74	2	3.30.800.10
Domain	PIP5K	PIP5K1A PIP5K1C	4.27e-04	8	74	2	PF01504
Domain	PIPK	PIP5K1A PIP5K1C	4.27e-04	8	74	2	PS51455
Domain	PInositol-4-P-5-kinase_N	PIP5K1A PIP5K1C	4.27e-04	8	74	2	IPR027484
Domain	PInositol-4-P-5-kinase_C	PIP5K1A PIP5K1C	4.27e-04	8	74	2	IPR027483
Domain	-	PIP5K1A PIP5K1C	4.27e-04	8	74	2	3.30.810.10
Domain	PInositol-4-P-5-kinase_core	PIP5K1A PIP5K1C	4.27e-04	8	74	2	IPR002498
Domain	TYR_PHOSPHATASE_PTP	PTPN14 PTPRB PTPRS	4.92e-04	39	74	3	PS50055
Domain	PTPase_domain	PTPN14 PTPRB PTPRS	5.71e-04	41	74	3	IPR000242
Domain	Y_phosphatase	PTPN14 PTPRB PTPRS	5.71e-04	41	74	3	PF00102
Domain	Clathrin_mu	STON2 AP1M2	6.83e-04	10	74	2	IPR001392
Domain	Adap_comp_sub	STON2 AP1M2	8.32e-04	11	74	2	PF00928
Domain	MHD	STON2 AP1M2	1.17e-03	13	74	2	PS51072
Domain	MHD	STON2 AP1M2	1.17e-03	13	74	2	IPR028565
Domain	Ras_G-nucl-exch_fac_CS	RASGRF1 RASGRF2	1.37e-03	14	74	2	IPR019804
Domain	PTPc_motif	PTPN14 PTPRB PTPRS	1.66e-03	59	74	3	SM00404
Domain	Tyr_Pase_cat	PTPN14 PTPRB PTPRS	1.66e-03	59	74	3	IPR003595
Domain	A/G_cyclase_CS	GUCY2D ADCY9	2.03e-03	17	74	2	IPR018297
Domain	Nucleotide_cyclase	GUCY2D ADCY9	2.27e-03	18	74	2	IPR029787
Domain	-	GUCY2D ADCY9	2.27e-03	18	74	2	3.30.70.1230
Domain	GUANYLATE_CYCLASE_1	GUCY2D ADCY9	2.54e-03	19	74	2	PS00452
Domain	Guanylate_cyc	GUCY2D ADCY9	2.54e-03	19	74	2	PF00211
Domain	GUANYLATE_CYCLASE_2	GUCY2D ADCY9	2.54e-03	19	74	2	PS50125
Domain	PDEase	PDE8A PDE8B	2.54e-03	19	74	2	IPR023088
Domain	A/G_cyclase	GUCY2D ADCY9	2.54e-03	19	74	2	IPR001054
Domain	CYCc	GUCY2D ADCY9	2.54e-03	19	74	2	SM00044
Domain	Tyr_Pase_AS	PTPN14 PTPRB PTPRS	3.04e-03	73	74	3	IPR016130
Domain	PDEase_I	PDE8A PDE8B	3.10e-03	21	74	2	PF00233
Domain	PDEASE_I	PDE8A PDE8B	3.10e-03	21	74	2	PS00126
Domain	PDEase_CS	PDE8A PDE8B	3.10e-03	21	74	2	IPR023174
Domain	-	PDE8A PDE8B	3.40e-03	22	74	2	1.10.1300.10
Domain	PDEase_catalytic_dom	PDE8A PDE8B	3.71e-03	23	74	2	IPR002073
Domain	HDc	PDE8A PDE8B	4.04e-03	24	74	2	SM00471
Domain	HD/PDEase_dom	PDE8A PDE8B	4.04e-03	24	74	2	IPR003607
Domain	IQ	RASGRF1 RASGRF2 UBE3C	4.08e-03	81	74	3	SM00015
Domain	PAS	PDE8A PDE8B	4.38e-03	25	74	2	PF00989
Domain	PAS_fold	PDE8A PDE8B	4.38e-03	25	74	2	IPR013767
Pubmed	RASGRF2 controls nuclear migration in postnatal retinal cone photoreceptors.	RASGRF1 RASGRF2	4.97e-06	2	78	2	26743081
Pubmed	cAMP-specific phosphodiesterases 8A and 8B, essential regulators of Leydig cell steroidogenesis.	PDE8A PDE8B	4.97e-06	2	78	2	22232524
Pubmed	Distinct roles for Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) and Ras-GRF2 in the induction of long-term potentiation and long-term depression.	RASGRF1 RASGRF2	4.97e-06	2	78	2	16467520
Pubmed	The high-affinity cAMP-specific phosphodiesterase 8B controls steroidogenesis in the mouse adrenal gland.	PDE8A PDE8B	4.97e-06	2	78	2	21187369
Pubmed	The environment versus genetics in controlling the contribution of MAP kinases to synaptic plasticity.	RASGRF1 RASGRF2	4.97e-06	2	78	2	17141611
Pubmed	Transgenerational rescue of a genetic defect in long-term potentiation and memory formation by juvenile enrichment.	RASGRF1 RASGRF2	4.97e-06	2	78	2	19193896
Pubmed	Type I phosphotidylinosotol 4-phosphate 5-kinase γ regulates osteoclasts in a bifunctional manner.	PIP5K1A PIP5K1C	4.97e-06	2	78	2	23300084
Pubmed	Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors.	RASGRF1 RASGRF2	4.97e-06	2	78	2	14749369
Pubmed	Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans.	PDE8A PDE8B	4.97e-06	2	78	2	12681444
Pubmed	PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions.	PIP5K1A PIP5K1C	4.97e-06	2	78	2	19889969
Pubmed	A murine CDC25/ras-GRF-related protein implicated in Ras regulation.	RASGRF1 RASGRF2	4.97e-06	2	78	2	8293576
Pubmed	cAMP-specific phosphodiesterase 8A and 8B isoforms are differentially expressed in human testis and Leydig cell tumor.	PDE8A PDE8B	4.97e-06	2	78	2	36277728
Pubmed	NLRP3 inflammasome activation is involved in Ang II-induced kidney damage via mitochondrial dysfunction.	AGTR1 NLRP3	4.97e-06	2	78	2	27509058
Pubmed	PI5KI-dependent signals are critical regulators of the cytolytic secretory pathway.	PIP5K1A PIP5K1C	4.97e-06	2	78	2	18073347
Pubmed	Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling.	PIP5K1A PIP5K1C	4.97e-06	2	78	2	12682053
Pubmed	Type I Phosphatidylinositol-4-Phosphate 5-Kinases α and γ Play a Key Role in Targeting HIV-1 Pr55Gag to the Plasma Membrane.	PIP5K1A PIP5K1C	4.97e-06	2	78	2	32376619
Pubmed	Ras-GRF2 regulates nestin-positive stem cell density and onset of differentiation during adult neurogenesis in the mouse dentate gyrus.	RASGRF1 RASGRF2	4.97e-06	2	78	2	28966131
Pubmed	PIPKIγ regulates β-catenin transcriptional activity downstream of growth factor receptor signaling.	CTNNB1 PIP5K1C	4.97e-06	2	78	2	21303971
Pubmed	Essential and unique roles of PIP5K-gamma and -alpha in Fcgamma receptor-mediated phagocytosis.	PIP5K1A PIP5K1C	4.97e-06	2	78	2	19153220
Pubmed	Dysregulation of the Scribble/YAP/β-catenin axis sustains the fibroinflammatory response in a PKHD1-/- mouse model of congenital hepatic fibrosis.	PKHD1 CTNNB1	4.97e-06	2	78	2	35593740
Pubmed	TRIM37 promoted the growth and migration of the pancreatic cancer cells.	CTNNB1 TRIM37	4.97e-06	2	78	2	26395261
Pubmed	The Inhibition of RasGRF2, But Not RasGRF1, Alters Cocaine Reward in Mice.	RASGRF1 RASGRF2	4.97e-06	2	78	2	31182637
Pubmed	Follicle-stimulating hormone/cAMP regulation of aromatase gene expression requires beta-catenin.	CYP19A1 CTNNB1	4.97e-06	2	78	2	16895991
Pubmed	RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation.	RASGRF1 RASGRF2	1.49e-05	3	78	2	21685891
Pubmed	β-catenin promotes NLRP3 inflammasome activation via increasing the association between NLRP3 and ASC.	CTNNB1 NLRP3	1.49e-05	3	78	2	32244067
Pubmed	Type I gamma phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct interaction with mu 1B adaptin.	AP1M2 PIP5K1C	1.49e-05	3	78	2	17261850
Pubmed	CLIC1 recruits PIP5K1A/C to induce cell-matrix adhesions for tumor metastasis.	PIP5K1A PIP5K1C	1.49e-05	3	78	2	33079727
Pubmed	Targeted disruption of Ras-Grf2 shows its dispensability for mouse growth and development.	RASGRF1 RASGRF2	1.49e-05	3	78	2	11909944
Pubmed	Enhancement of β-catenin activity by BIG1 plus BIG2 via Arf activation and cAMP signals.	ARFGEF1 CTNNB1	1.49e-05	3	78	2	27162341
Pubmed	Developmentally regulated role for Ras-GRFs in coupling NMDA glutamate receptors to Ras, Erk and CREB.	RASGRF1 RASGRF2	1.49e-05	3	78	2	15029245
Pubmed	Angiotensin receptors and β-catenin regulate brain endothelial integrity in malaria.	AGTR1 CTNNB1	1.49e-05	3	78	2	27643439
Pubmed	Activation of type I phosphatidylinositol 4-phosphate 5-kinase isoforms by the Rho GTPases, RhoA, Rac1, and Cdc42.	PIP5K1A PIP5K1C	1.49e-05	3	78	2	14681219
Pubmed	PIP5KIβ selectively modulates apical endocytosis in polarized renal epithelial cells.	PIP5K1A PIP5K1C	1.49e-05	3	78	2	23342003
Pubmed	Phosphatidylinositol-4-phosphate 5-kinase isoforms exhibit acyl chain selectivity for both substrate and lipid activator.	PIP5K1A PIP5K1C	1.49e-05	3	78	2	22942276
Pubmed	Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta.	PTPRB CTNNB1	2.97e-05	4	78	2	10706604
Pubmed	Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes.	PIP5K1A PIP5K1C	2.97e-05	4	78	2	18188447
Pubmed	Multiple post-translational modifications regulate E-cadherin transport during apoptosis.	CTNNB1 PIP5K1C	2.97e-05	4	78	2	22375065
Pubmed	Structural and spatial determinants regulating TC21 activation by RasGRF family nucleotide exchange factors.	RASGRF1 RASGRF2	2.97e-05	4	78	2	19692568
Pubmed	Identification and characterization of a phosphoinositide phosphate kinase homolog.	PIP5K1A PIP5K1C	2.97e-05	4	78	2	14701839
Pubmed	Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family.	PIP5K1A PIP5K1C	2.97e-05	4	78	2	9535851
Pubmed	RasGRF Couples Nox4-Dependent Endoplasmic Reticulum Signaling to Ras.	RASGRF1 RASGRF2	2.97e-05	4	78	2	27856453
Pubmed	Ras-guanine-nucleotide-releasing factors 1 and 2 interact with PLCγ at focal adhesions to enable IL-1-induced Ca(2+) signalling, ERK activation and MMP-3 expression.	RASGRF1 RASGRF2	2.97e-05	4	78	2	23145787
Pubmed	Pde8b haploinsufficiency in mice is associated with modest adrenal defects, impaired steroidogenesis, and male infertility, unaltered by concurrent PKA or Wnt activation.	PDE8B CTNNB1	2.97e-05	4	78	2	33338547
Pubmed	RRM1, TUBB3, TOP2A, CYP19A1, CYP2D6: Difference between mRNA and protein expression in predicting prognosis of breast cancer patients.	CYP19A1 RRM1	4.94e-05	5	78	2	26252353
Pubmed	The importance of E-cadherin binding partners to evaluate the pathogenicity of E-cadherin missense mutations associated to HDGC.	CTNNB1 PIP5K1C	4.94e-05	5	78	2	22850631
Pubmed	The lipid kinase PIP5K1C regulates pain signaling and sensitization.	PIP5K1A PIP5K1C	4.94e-05	5	78	2	24853942
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	PTPN14 TSR1 RPS15 PSMC6 PIP5K1A NCBP1 CCT4 RGS11 CTNNB1 RRM1	6.21e-05	971	78	10	33306668
Pubmed	Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1.	PIP5K1A PIP5K1C	7.40e-05	6	78	2	14614850
Pubmed	Rac controls PIP5K localisation and PtdIns(4,5)P₂ synthesis, which modulates vinculin localisation and neurite dynamics.	PIP5K1A PIP5K1C	7.40e-05	6	78	2	20841379
Pubmed	ARTS mediates apoptosis and regeneration of the intestinal stem cell niche.	SEPTIN4 CTNNB1	7.40e-05	6	78	2	30389919
Pubmed	Smurf1 regulates lung cancer cell growth and migration through interaction with and ubiquitination of PIPKIγ.	PIP5K1A PIP5K1C	7.40e-05	6	78	2	28581524
Pubmed	Phosphatidylinositol 4,5-bisphosphate regulates adipocyte actin dynamics and GLUT4 vesicle recycling.	PIP5K1A PIP5K1C	7.40e-05	6	78	2	15123724
Pubmed	The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin.	PTPN14 CTNNB1	1.04e-04	7	78	2	12808048
Pubmed	Long-term potentiation in the CA1 hippocampus induced by NR2A subunit-containing NMDA glutamate receptors is mediated by Ras-GRF2/Erk map kinase signaling.	RASGRF1 RASGRF2	1.04e-04	7	78	2	20661302
Pubmed	Localization of mRNAs for phosphatidylinositol phosphate kinases in the mouse brain during development.	PIP5K1A PIP5K1C	1.04e-04	7	78	2	15018809
Pubmed	Identification and typing of members of the protein-tyrosine phosphatase gene family expressed in mouse brain.	PTPRB PTPRS	1.04e-04	7	78	2	1454056
Pubmed	HIV-1 Tat C phosphorylates VE-cadherin complex and increases human brain microvascular endothelial cell permeability.	PTPRB CTNNB1	1.38e-04	8	78	2	24965120
Pubmed	Btk-dependent regulation of phosphoinositide synthesis.	PIP5K1A PIP5K1C	1.38e-04	8	78	2	15046600
Pubmed	Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain.	PIP5K1A PIP5K1C	1.38e-04	8	78	2	20622009
Pubmed	A Large-scale genetic association study of esophageal adenocarcinoma risk.	CYP19A1 CYP24A1 GUCY2D RGS11 ALDH1L1 RRM1	1.41e-04	351	78	6	20453000
Pubmed	LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6.	LRRK1 CTNNB1	1.77e-04	9	78	2	22899650
Pubmed	Cutting edge: nitrogen bisphosphonate-induced inflammation is dependent upon mast cells and IL-1.	LYST NLRP3	1.77e-04	9	78	2	22387558
Pubmed	Comparative phenotypic analysis of the two major splice isoforms of phosphatidylinositol phosphate kinase type Iγ in vivo.	PIP5K1A PIP5K1C	1.77e-04	9	78	2	22976293
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	PTPN14 HMCN2 CHD5 AOX1 C16orf96 TAF2 EZH1 IQCM ADCY9 UNC80	1.94e-04	1116	78	10	31753913
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	PTPN14 PTPRS PIP5K1A CTNNB1 PIP5K1C ADCY9	2.08e-04	377	78	6	38117590
Pubmed	Analysis of differential gene expression by display of 3' end restriction fragments of cDNAs.	CTNNB1 APOBEC3F	2.21e-04	10	78	2	8570611
Pubmed	The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.	TSR1 CHD5 RPS15 PSMC6 PIP5K1A NCBP1 CCT4 POTEKP RRM1 PIP5K1C	2.51e-04	1153	78	10	29845934
Pubmed	Brain-specific Pd1 deficiency leads to cortical neurogenesis defects and depressive-like behaviors in mice.	ALDH1L1 CTNNB1	2.70e-04	11	78	2	37553426
Pubmed	A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain.	PTPRB PTPRS	2.70e-04	11	78	2	7832766
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	PTPN14 TSR1 STON2 PSMC6 CCT4 CTNNB1	2.81e-04	399	78	6	37536630
Pubmed	Single and multigenic analysis of the association between variants in 12 steroid hormone metabolism genes and risk of prostate cancer.	CYP19A1 CYP24A1	3.23e-04	12	78	2	19505920
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	TBCCD1 TRPC4AP PTPN14 PTPRS RPS15 PSMC6 PIP5K1A CCT4 UBE3C	3.30e-04	974	78	9	28675297
Pubmed	Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1.	RAPGEF6 PTPN14 RPS15 CCT4 TAF2	3.61e-04	270	78	5	24366813
Pubmed	USP9X Deubiquitylates DVL2 to Regulate WNT Pathway Specification.	RAPGEF6 PTPN14 PSMC6	3.73e-04	62	78	3	31340145
Pubmed	Crucial Role of Rapgef2 and Rapgef6, a Family of Guanine Nucleotide Exchange Factors for Rap1 Small GTPase, in Formation of Apical Surface Adherens Junctions and Neural Progenitor Development in the Mouse Cerebral Cortex.	RAPGEF6 CTNNB1	3.81e-04	13	78	2	27390776
Pubmed	Casein kinase 1α mediates estradiol secretion via CYP19A1 expression in mouse ovarian granulosa cells.	CYP19A1 CTNNB1	4.44e-04	14	78	2	39183304
Pubmed	Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf.	RASGRF1 RASGRF2	4.44e-04	14	78	2	10373510
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	SLC25A24 TSR1 PTPRS PSMC6 UGGT2 CCT4 RRM1	4.57e-04	613	78	7	22268729
Pubmed	The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1.	RASGRF1 RASGRF2	5.12e-04	15	78	2	14622581
Pubmed	Association of dysfunctional synapse defective 1 (SYDE1) with restricted fetal growth - SYDE1 regulates placental cell migration and invasion.	AGTR1 CTNNB1	5.12e-04	15	78	2	27917469
Pubmed	Inactivation of LAR family phosphatase genes Ptprs and Ptprf causes craniofacial malformations resembling Pierre-Robin sequence.	PTPRS CTNNB1	5.12e-04	15	78	2	23863482
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PTPN14 PTPRB TSR1 PTPRS RPS15 PSMC6 NCBP1 CCT4 ADCY9	5.65e-04	1049	78	9	27880917
Pubmed	Essential requirement of mammalian Pumilio family in embryonic development.	PUM2 CTNNB1	5.84e-04	16	78	2	30256721
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	SLC25A24 RPS15 PSMC6 NCBP1 CCT4 UBE3C CTNNB1	6.29e-04	647	78	7	26618866
Pubmed	Protein tyrosine phosphatases expression during development of mouse superior colliculus.	PTPN14 PTPRS	6.61e-04	17	78	2	19727691
Pubmed	Lack of CUL4B leads to increased abundance of GFAP-positive cells that is mediated by PTGDS in mouse brain.	ALDH1L1 CTNNB1	6.61e-04	17	78	2	26025376
Pubmed	The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse.	PKHD1 CTNNB1	6.61e-04	17	78	2	16472605
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	TSR1 STON2 NCBP1 RGS11 UBE3C CTNNB1 RRM1	6.65e-04	653	78	7	33742100
Pubmed	Characterization of Dynamic UbR-Proteasome Subcomplexes by In vivo Cross-linking (X) Assisted Bimolecular Tandem Affinity Purification (XBAP) and Label-free Quantitation.	PSMC6 CCT4 UBE3C	7.31e-04	78	78	3	27114451
Pubmed	Misregulation of an Activity-Dependent Splicing Network as a Common Mechanism Underlying Autism Spectrum Disorders.	SHANK1 RAPGEF6	7.42e-04	18	78	2	27984743
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	HMCN2 TSR1 MTERF3 STON2 RPS15 PSMC6 PIP5K1A NCBP1 CCT4 POTEKP	7.89e-04	1335	78	10	29229926
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	RAPGEF6 ZBED4 PTPRS CHD5 LRRK1 UBE3C PIP5K1C LYST ADCY9	8.17e-04	1105	78	9	35748872
Pubmed	WNT signaling represses astrogliogenesis via Ngn2-dependent direct suppression of astrocyte gene expression.	ALDH1L1 CTNNB1	8.28e-04	19	78	2	30889310
Pubmed	Meta-analysis identifies four new loci associated with testicular germ cell tumor.	SEPTIN4 TRIM37	9.19e-04	20	78	2	23666239
Pubmed	Ubiquitin-protein ligase E3C maintains non-small-cell lung cancer stemness by targeting AHNAK-p53 complex.	UBE3C RRM1	1.01e-03	21	78	2	30503554
Pubmed	The sequence and analysis of duplication-rich human chromosome 16.	RRN3P2 C16orf96 RGS11	1.11e-03	90	78	3	15616553
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	TSR1 MTERF3 RPS15 PUM2 PIP5K1A NCBP1 APOBEC3F	1.11e-03	713	78	7	29802200
Pubmed	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	SLC25A24 MTRF1 SLC25A36 SEPTIN4 CYP24A1 MTERF3 NIPSNAP1 ALDH1L1	1.11e-03	926	78	8	20877624
Pubmed	p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation.	SUPT20HL1 CTNNB1	1.11e-03	22	78	2	16751104
Pubmed	Comprehensive Target Screening and Cellular Profiling of the Cancer-Active Compound b-AP15 Indicate Abrogation of Protein Homeostasis and Organelle Dysfunction as the Primary Mechanism of Action.	PSMC6 CCT4 UBE3C	1.18e-03	92	78	3	35530310
GeneFamily	Protein tyrosine phosphatases, receptor type	PTPRB PTPRS	1.46e-03	21	49	2	813
GeneFamily	Phosphodiesterases	PDE8A PDE8B	1.91e-03	24	49	2	681
Coexpression	GSE17721_CPG_VS_GARDIQUIMOD_6H_BMDC_DN	HIVEP1 PDE8A UGGT2 NCBP1 ZC3H12C LRRK1 NLRP3	2.27e-06	200	78	7	M3891
ToppCell	Macroglial-Oligodendrocytes\|Macroglial / cells hierarchy compared to all cells using T-Statistic	GREB1L SLC44A1 PDE8A SEPTIN4 ST6GALNAC3 SLC7A14	1.41e-06	200	78	6	4dbac2f2587e87ca5a0622f50439bb5447e93c7f
ToppCell	Macroglial-Oligodendrocytes-OPALIN--\|Macroglial / cells hierarchy compared to all cells using T-Statistic	GREB1L SLC44A1 PDE8A SEPTIN4 ST6GALNAC3 SLC7A14	1.41e-06	200	78	6	26b989e30bbbaf30904ced03f6aae3dea25c732c
ToppCell	Macroglial-Oligodendrocytes-OPALIN---\|Macroglial / cells hierarchy compared to all cells using T-Statistic	GREB1L SLC44A1 PDE8A SEPTIN4 ST6GALNAC3 SLC7A14	1.41e-06	200	78	6	1314664c1721e9ecb1e2c3482a039044b0fe50a9
ToppCell	Macroglial-Oligodendrocytes-OPALIN-\|Macroglial / cells hierarchy compared to all cells using T-Statistic	GREB1L SLC44A1 PDE8A SEPTIN4 ST6GALNAC3 SLC7A14	1.41e-06	200	78	6	8b229f095fc113aecfc94b64862a9e0fdcc363ce
ToppCell	Macroglial-Oligodendrocytes-OPALIN----L1-6\|Macroglial / cells hierarchy compared to all cells using T-Statistic	GREB1L SLC44A1 PDE8A SEPTIN4 ST6GALNAC3 SLC7A14	1.41e-06	200	78	6	272909f4354f3ae22e2b2f8f35970e6b0e92cfe2
ToppCell	Macroglial-Oligodendrocytes-OPALIN\|Macroglial / cells hierarchy compared to all cells using T-Statistic	GREB1L SLC44A1 PDE8A SEPTIN4 ST6GALNAC3 SLC7A14	1.41e-06	200	78	6	5f75a9b8bcd49d9bbb1e9ce2de730eaec96369ca
ToppCell	COVID-19-Endothelial_cells-Arterial_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	PTPN14 PTPRB HMCN2 RASGRF2 ST6GALNAC3	1.80e-05	184	78	5	0f19494789f38ab1a420545e15e748ca7eb345c3
ToppCell	COVID-19-kidney-FLT1+PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PTPRB PDE8A RASGRF2 ST6GALNAC3 CTNNB1	1.84e-05	185	78	5	673308ca0514a4d3629d61fe91e9d8fb31b72166
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PTPN14 PTPRB RASGRF2 ST6GALNAC3 RGS11	1.84e-05	185	78	5	a7ae76058b2082020cadec49d63b9f4e24d21734
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB HMCN2 RASGRF2 ST6GALNAC3 CTNNB1	2.04e-05	189	78	5	6463890d8dbee4bc198f91628a5f784970de786a
ToppCell	COVID-19-Heart-EC_3\|Heart / Disease (COVID-19 only), tissue and cell type	PTPRB RASGRF2 ST6GALNAC3 MAMLD1 LYST	2.10e-05	190	78	5	78e7c502b0450c0b37652b1896a2a752fd8a2111
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PTPN14 PTPRB RASGRF2 ST6GALNAC3 RGS11	2.10e-05	190	78	5	f6c38d197fd9d69a4f97cb2e72cd4747984c1a86
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PTPRS AGTR1 AOX1 MAMLD1 ALDH1L1	2.26e-05	193	78	5	261cafc167c86ab277be4ea7f08b0173e2dde26e
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB HMCN2 RASGRF2 ST6GALNAC3 CTNNB1	2.37e-05	195	78	5	6bdef651cf73d7381e5012d0eb3c809138fb6b92
ToppCell	Fetal_29-31_weeks-Immune-dendritic_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	THEMIS2 CYP19A1 GUCY2D LRRK1	1.40e-04	150	78	4	57f21ad380fd1350a2c25d75ad8c3b763ded53ec
ToppCell	facs-Liver-Non-hepatocytes-3m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GREB1L RASGRF1 PDE8B NLRP3	1.47e-04	152	78	4	b61d2f6ee819c8dd4b4b601a8bc8388b1983de58
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_0\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PNMA5 S1PR3 ADCY9 NLRP3	1.75e-04	159	78	4	2f6c60ddff2208a68146f9786143d9aefd528840
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_0\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PNMA5 S1PR3 ADCY9 NLRP3	1.75e-04	159	78	4	ded4e3626a62fb6334403b7213b467fb7e8131c3
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB HMCN2 ST6GALNAC3 RRM1	2.06e-04	166	78	4	8e2faca6a2e76a625de04d6098aa6f98911945c6
ToppCell	droplet-Liver-Npc-18m-Myeloid-plasmacytoid_dendritic_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF1 CHD5 CXXC5 AP1M2	2.11e-04	167	78	4	1248f809afbcccb42ce9e29cfe6fa1f6f6b65005
ToppCell	droplet-Liver-Npc-18m-Myeloid-plasmacytoid_dendritic_cells\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF1 CHD5 CXXC5 AP1M2	2.11e-04	167	78	4	a66552667aa6e8992c159df27a57c2e8ae14a9ce
ToppCell	facs-Heart-RV-24m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRB RASGRF2 SEPTIN4 TRIM37	2.16e-04	168	78	4	831b000e26b4a7e7fdfa3988372e0281c45eadbb
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SEPTIN4 AGTR1 MAMLD1 S1PR3	2.26e-04	170	78	4	876b84740e15399bfff2b9c7f0b80fd759bbdb3f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SEPTIN4 AGTR1 MAMLD1 S1PR3	2.26e-04	170	78	4	1f8738acf439d893880db7e1fdc9b3615ca00c39
ToppCell	COVID_vent-Lymphocytic-Dendritic-pDC\|COVID_vent / Disease condition, Lineage, Cell class and subclass	TRHR PTPRS GUCY2D LRRK1	2.31e-04	171	78	4	779c951d274ecbd1d546ac425d6c8e718623be5a
ToppCell	COVID_vent-Lymphocytic-Dendritic\|COVID_vent / Disease condition, Lineage, Cell class and subclass	TRHR PTPRS GUCY2D LRRK1	2.31e-04	171	78	4	debbb071d260639b16269c94d172766908325c58
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PTPN14 PTPRB RASGRF2 ST6GALNAC3	2.31e-04	171	78	4	1597459c971d6befa991d59dc66b41b6a522f797
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Plasmacytoid_Dendritic_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	THEMIS2 PTPRS GUCY2D LRRK1	2.31e-04	171	78	4	af1c93eb75f45c042ea475d93db56e4da207e31f
ToppCell	3'_v3-bone_marrow-Hematopoietic_progenitors-Cycling_pre-Lymphocytic-T\|bone_marrow / Manually curated celltypes from each tissue	SLC44A1 GUCY2D UGGT2 RRM1	2.47e-04	174	78	4	1e289b26e2c29dbad15b712a999b96c391a26129
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB RASGRF2 ST6GALNAC3 CTNNB1	2.47e-04	174	78	4	3d4c05ea5719ca65e85d1f15198453034791087c
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PTPRS AOX1 MAMLD1 IQCM	2.47e-04	174	78	4	1d157f7a919c8246e83d8060d2a0017c6c781ef3
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1_FGFR3_FOS\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	AGTR1 STON2 ALDH1L1 PLXNB3	2.58e-04	176	78	4	2bc4d3ddc2f752d8255dec0e7a9b87c7f82a372d
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SEPTIN4 PDE8B AGTR1 S1PR3	2.58e-04	176	78	4	e9152defb4fd41267fb33c42c01fd0c683280783
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SEPTIN4 PDE8B AGTR1 S1PR3	2.58e-04	176	78	4	a4d269075aa0efc46fa251b379f334e50c69391d
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SEPTIN4 PDE8B AGTR1 S1PR3	2.58e-04	176	78	4	cc6f65a7d2c622841c9d1ab3755586039d4ccc4d
ToppCell	RV-11._Adipocyte\|World / Chamber and Cluster_Paper	PTPRS PDE8B MAMLD1 ALDH1L1	2.63e-04	177	78	4	f0edf04930692418953e4f00a917257804ec0ffd
ToppCell	RV-11._Adipocyte\|RV / Chamber and Cluster_Paper	PTPRS PDE8B MAMLD1 ALDH1L1	2.69e-04	178	78	4	278bbea5cf8f0589f71675c7a3d00679391b5253
ToppCell	facs-Trachea-24m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l7\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PTPRB RASGRF2 SEPTIN4 TRIM37	2.69e-04	178	78	4	a3f95f0002f408b5b6c57e28b297b5b2737e919c
ToppCell	COVID-19-kidney-PCT-S2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CYP24A1 AOX1 PKHD1 ALDH1L1	2.81e-04	180	78	4	358923e4228035a3e90e2957392089219e90dcd7
ToppCell	COVID-19-kidney-tDL\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CYP24A1 AOX1 PKHD1 ALDH1L1	2.81e-04	180	78	4	864c895b5eaedefae86f5829fa344f7b686fb59f
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SEPTIN4 PDE8B AGTR1 S1PR3	2.87e-04	181	78	4	a2058d658f07ab6f0a28d2622f3090b4cde6f763
ToppCell	Control-Classical_Monocyte-cMono_4\|Control / Disease condition and Cell class	THEMIS2 CXXC5 CTNNB1 NLRP3	2.87e-04	181	78	4	f3e1d8fe5cf1eba19e51c3680a55306cae687fe9
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SEPTIN4 PDE8B AGTR1 S1PR3	2.87e-04	181	78	4	526e858a848470b6d2d5248788004d9735ed3add
ToppCell	droplet-Lung-1m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PTPRB RASGRF2 PTPRS AOX1	2.87e-04	181	78	4	136b0c60680068838d184d32aa99d7bea8718dbc
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-2\|TCGA-Skin / Sample_Type by Project: Shred V9	RASGRF1 CTNNB1 LYST TRIM37	2.87e-04	181	78	4	9d5b331cabc5524f0a9fd8b571e87be4c447c7d4
ToppCell	facs-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PTPRB RASGRF2 GUCY2D SYT6	2.93e-04	182	78	4	d22ab50b135482915687c70e6dad29bfe2bb2c68
ToppCell	5'-GW_trimst-2-LargeIntestine-Neuronal-neurons_B-Branch_B1_(eMN)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CHD5 SYT6 SLC7A14 UNC80	2.99e-04	183	78	4	7e2bac8b005155888ff4b41ef2e1d975dc17abc7
ToppCell	COVID-19-kidney-PCT-S1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CYP24A1 AOX1 PKHD1 ALDH1L1	2.99e-04	183	78	4	6878d14026c3df6aa12e45dfad94b32fa9d9b0b7
ToppCell	droplet-Heart-4Chambers-21m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPN14 PTPRB SEPTIN4 TRIM37	3.05e-04	184	78	4	f17d713af4a97dff4eeeab24c405677ef2ffcf84
ToppCell	droplet-Limb_Muscle-nan-21m-Macroglial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF1 CHD5 UNC80 PLXNB3	3.05e-04	184	78	4	9f8cd5ab5af6c35a1be25d70a125b9a3f4dd667a
ToppCell	droplet-Limb_Muscle-nan-21m-Macroglial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF1 CHD5 UNC80 PLXNB3	3.11e-04	185	78	4	3d1353dbcb60e2531ef67e1bd218b7bc4d7c7c9b
ToppCell	droplet-Limb_Muscle-nan-21m-Macroglial-Schwann_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF1 CHD5 UNC80 PLXNB3	3.11e-04	185	78	4	995a8ddc3fd8e6879d8b5de8cbdefe232d34833b
ToppCell	COVID-19-Neuronal_cells-Neuronal_cells\|COVID-19 / group, cell type (main and fine annotations)	PTPN14 PTPRB ST6GALNAC3 STON2	3.11e-04	185	78	4	4a095829992b39856a73bdfac03ee68b9aa0d3b8
ToppCell	pdx-Tumor_cells-T0\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	AOX1 NIPSNAP1 PKHD1 ALDH1L1	3.11e-04	185	78	4	1d874608aa2062024323512f68889219471b2f00
ToppCell	COVID-19-kidney-Mito-rich_PCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CYP24A1 AOX1 PKHD1 ALDH1L1	3.11e-04	185	78	4	1bbc2ba8a20f72f61981b1301cdd6018cdd9150d
ToppCell	COVID-19-Neuronal_cells\|COVID-19 / group, cell type (main and fine annotations)	PTPN14 PTPRB ST6GALNAC3 STON2	3.11e-04	185	78	4	36ce23893915f5c380cca39b2c33a516edf31c3a
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPN14 PTPRB RASGRF2 TRIM37	3.11e-04	185	78	4	bdd2e6cb20294b39a9d856004bf57ba69cf877e2
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c5-WDR74\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	THEMIS2 CYP19A1 CXXC5 NLRP3	3.11e-04	185	78	4	68edb1bb03ed221d49e583123ca4de14252d7bc5
ToppCell	droplet-Bladder-nan-24m-Endothelial-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRB RASGRF2 ST6GALNAC3 SLC7A14	3.11e-04	185	78	4	90caab8d9361a541c5d5121c97c3f1cdffeeae4a
ToppCell	droplet-Heart-nan-3m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPN14 PTPRB LYST TRIM37	3.18e-04	186	78	4	0ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCell	5'-GW_trimst-2-LargeIntestine-Neuronal-neurons_B\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CHD5 SYT6 SLC7A14 UNC80	3.18e-04	186	78	4	15f2e5905486e33f6f7b3b3e9758a0559e8c61ee
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-Pericytes-Pericyte\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SEPTIN4 PDE8B AGTR1 S1PR3	3.18e-04	186	78	4	0c477016c1b539b3086a8066c3c6443f08c222a3
ToppCell	droplet-Lung-3m-Endothelial-venous_endothelial-vein_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PTPN14 PTPRB ST6GALNAC3 TRIM37	3.24e-04	187	78	4	3827fa80e558b642f3e0036f5ee1a8b69f437e30
ToppCell	droplet-Lung-3m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PTPN14 PTPRB ST6GALNAC3 TRIM37	3.24e-04	187	78	4	1bf696eb03422ea507d3efe58dda1d442a65225d
ToppCell	droplet-Lung-3m-Endothelial-venous_endothelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PTPN14 PTPRB ST6GALNAC3 TRIM37	3.24e-04	187	78	4	ebe4d1216cc0d4c079b413d5a5460cfd3a4af922
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-Pericytes-Immature_pericyte\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SEPTIN4 AGTR1 CXXC5 S1PR3	3.24e-04	187	78	4	6820bfbe552ea5e62cfe699687b051a17d9fda61
ToppCell	human_hepatoblastoma-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	RASGRF2 PKHD1 ALDH1L1 LYST	3.24e-04	187	78	4	f3e37c18ac6471c7992609bbddfa4975571c815c
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel-D175\|Adult / Lineage, Cell type, age group and donor	PTPN14 PTPRB ST6GALNAC3 STON2	3.24e-04	187	78	4	1e52d3d9d664c813d859b5b75e4c07b218818f95
ToppCell	droplet-Fat-SCAT-30m-Endothelial-Cd36+\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRB RASGRF2 SEPTIN4 TRIM37	3.31e-04	188	78	4	e901a9bdf00b8e91806f445af66647373bf62661
ToppCell	COVID-19-lung-Artery_EC\|lung / Disease (COVID-19 only), tissue and cell type	PTPN14 PTPRB RASGRF2 ST6GALNAC3	3.31e-04	188	78	4	eecd7482b3c97d7f49993cb17edfab30c61232fc
ToppCell	droplet-Fat-Scat-21m-Endothelial-Cd36+\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRB RASGRF2 SEPTIN4 TRIM37	3.31e-04	188	78	4	8671fdbc4138e6f9559920779c98628ed80f0da3
ToppCell	Endothelial-endothelial_cell_of_lymph_vessel\|World / Lineage, Cell type, age group and donor	PTPN14 PTPRB ST6GALNAC3 STON2	3.31e-04	188	78	4	80910dcbb51990f2baed240f319456c0d3fa2065
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PTPN14 PTPRB ST6GALNAC3 STON2	3.31e-04	188	78	4	c2805232618a7b6f844d34e37ad458a9923dbfe1
ToppCell	droplet-Mammary_Gland-nan-21m-Endothelial-endothelial_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRB RASGRF2 SEPTIN4 TRIM37	3.31e-04	188	78	4	05de6677f9bb4b00fed47f4b72f4a2cd507cb0f2
ToppCell	droplet-Fat-SCAT-30m-Endothelial-endothelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRB RASGRF2 SEPTIN4 TRIM37	3.31e-04	188	78	4	5cf060bb8adaefa9964187195d67993c1248ef47
ToppCell	droplet-Fat-SCAT-30m-Endothelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRB RASGRF2 SEPTIN4 TRIM37	3.31e-04	188	78	4	449f9602df3c83b2110eb479a00d428d1b55b423
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PTPN14 PTPRB ST6GALNAC3 STON2	3.31e-04	188	78	4	2db80767903703e7e0a1a37c598f7877a909ee94
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PTPRB RASGRF2 ST6GALNAC3 STON2	3.38e-04	189	78	4	0d18ea72bd58d32a8ab9a61cf97f5786642f804b
ToppCell	Endothelial-endothelial_cell_of_artery\|World / Lineage, Cell type, age group and donor	PTPN14 PTPRB RASGRF2 ST6GALNAC3	3.38e-04	189	78	4	fdd89c71113ac99b7c800c6def8888e512ff1128
ToppCell	droplet-Mammary_Gland-nan-21m-Endothelial-endothelial_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRB RASGRF2 SEPTIN4 TRIM37	3.38e-04	189	78	4	8ced0381ea042ba47680a02b617a2368fa2c54c8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GREB1L PTPN14 CYP24A1 RPS15	3.38e-04	189	78	4	1ecf9911ff82e0ca0f0c101b735d3b1f3b339d57
ToppCell	droplet-Liver-Hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRB SEPTIN4 ST6GALNAC3 TRIM37	3.38e-04	189	78	4	ce5b3d53c9a5457a5a02b221dee18334b5eaf8b7
ToppCell	droplet-Mammary_Gland-nan-21m-Endothelial\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRB RASGRF2 SEPTIN4 TRIM37	3.38e-04	189	78	4	403a82bb416aed13b9d31411ad17bdc4ce2a95fb
ToppCell	droplet-Fat-Scat-21m-Endothelial-endothelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRB RASGRF2 SEPTIN4 TRIM37	3.44e-04	190	78	4	d3e46cf800a07ca9b01c78192962d223b9785d05
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PTPN14 PTPRB ST6GALNAC3 STON2	3.44e-04	190	78	4	6e6ce6dd549d1c38cfef5b3f8be06ab01ce344b7
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Artery\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PTPRB RASGRF2 MAMLD1 LRRK1	3.44e-04	190	78	4	aed65d584ca0c25f6a8313c66b421a6618af82ea
ToppCell	facs-SCAT-Fat-18m-Endothelial-nan\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRB RASGRF2 SEPTIN4 TRIM37	3.44e-04	190	78	4	b0c9dae8189d407c94964c6bfe3ef92035245357
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Macrophage\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	THEMIS2 PKHD1 LYST NLRP3	3.44e-04	190	78	4	e1c02fe6fa43a36381cb9f02569fa9b1c5f5efdc
ToppCell	droplet-Fat-Scat-21m-Endothelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRB RASGRF2 SEPTIN4 TRIM37	3.44e-04	190	78	4	dd89ef1ecea20b2f6fbdc6cea4ca41b28b3ed822
ToppCell	facs-SCAT-Fat-18m-Endothelial\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRB RASGRF2 SEPTIN4 TRIM37	3.44e-04	190	78	4	ee63dc04e91ad49aa7820c98e97261176ecebaa6
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Endothelial-endothelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRB RASGRF2 SEPTIN4 TRIM37	3.44e-04	190	78	4	c8370c922e0cf0e0c36e02e1ed2b4053ad6a8073
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel\|Adult / Lineage, Cell type, age group and donor	PTPN14 PTPRB ST6GALNAC3 STON2	3.44e-04	190	78	4	91bf3b7e9148589757436a53a4f58e0ebfe54400
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-intestinal_crypt_stem_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE8B NIPSNAP1 CCT4 RRM1	3.44e-04	190	78	4	c0ee404d705b0b4f0c6ded4d070ad85eac4b16db
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Endothelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRB RASGRF2 SEPTIN4 TRIM37	3.44e-04	190	78	4	5174f91a880f85bb20806023aa68bd4b8ca24ea5
ToppCell	facs-SCAT-Fat-18m-Endothelial-endothelial_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRB RASGRF2 SEPTIN4 TRIM37	3.44e-04	190	78	4	0e50808bfc3d0820524c8470ae3e8250819d65b2
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PAN2 UGGT2 NCBP1 RRM1	3.44e-04	190	78	4	3f0c7d130f66faea778fe567604edf1b4cdf85b3
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Macrophage-macrophage,_alveolar\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	THEMIS2 PKHD1 LYST NLRP3	3.44e-04	190	78	4	6de15ec88426fbf52acb0a8371f82cf03b6a6237
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Endothelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRB RASGRF2 SEPTIN4 TRIM37	3.44e-04	190	78	4	90e494cbfbed33a3a0d29bb7dae83f0c81580bcf
ToppCell	E16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal\|E16.5-samps / Age Group, Lineage, Cell class and subclass	SEPTIN4 PTPRS UGGT2 S1PR3	3.51e-04	191	78	4	3379d145d34f89150f7b06d1340022cfc6b4a6ce
ToppCell	droplet-Trachea-3m-Epithelial-airway_epithelial-neuroendocrine_cell-neuroendocrine\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PDE8B AGTR1 S1PR3 PLXNB3	3.51e-04	191	78	4	72f1ddc09080dbfea8d51294cbf7f9d4925f9cc0
Disease	Colorectal Carcinoma	SHANK1 RASGRF2 PTPRS CHD5 PKHD1 PAN2 ARFGEF1 ALDH1L1 CTNNB1	7.98e-05	702	76	9	C0009402
Disease	placental insufficiency (biomarker_via_orthology)	CYP19A1 AGTR1	1.81e-04	8	76	2	DOID:3891 (biomarker_via_orthology)
Disease	Hemangiosarcoma	PTPRB CTNNB1	9.75e-04	18	76	2	C0018923
Disease	Adrenocortical carcinoma	CTNNB1 RRM1	9.75e-04	18	76	2	C0206686
Disease	thyroid stimulating hormone measurement	PTPN14 TRHR PTPRS PDE8B ADCY9	1.49e-03	323	76	5	EFO_0004748
Disease	endometriosis (is_marker_for)	CYP19A1 CTNNB1	1.89e-03	25	76	2	DOID:289 (is_marker_for)
Disease	serum non-albumin protein measurement	GREB1L FAM178B GUCY2D LRRK1 NLRP3	2.42e-03	361	76	5	EFO_0004568

Protein segments in the cluster

Peptide	Gene	Start	Entry
AMSKIEHFMPLLVQR	AP1M2	26	Q9Y6Q5
VAKRKMMLTHLVVRP	CHD5	1161	Q8TDI0
HRMQKEITALAPSIM	POTEKP	311	Q9BYX7
EHIMKRNRSPTIRDM	ARFGEF1	1241	Q9Y6D6
VHPMKSRLRRTMLVA	AGTR1	131	P30556
VHTKMIQVVSRELRM	AOX1	1051	Q06278
MPHLRKMERVVVSMQ	RGS11	16	O94810
ITPKLIRMVTVMQAH	IQCM	286	A0A1B0GVH7
MAEPAQRKIIMHKIR	PUM2	1011	Q8TB72
HTLRQISERDPMMQK	PCDHB1	626	Q9Y5F3
DLRMMRAITPLQVHV	PAN2	271	Q504Q3
KEASRHAIMRSPQMV	CTNNB1	181	P35222
HAIMRSPQMVSAIVR	CTNNB1	186	P35222
NIMMLVPHKRYLVSI	PTPRB	1411	P23467
NHPQMIAVLVDKMIR	NCBP1	596	Q09161
GPRVTAVIMVMHSVL	GUCY2D	236	Q02846
MRHPTANTIQRVFKM	LRRK1	1006	Q38SD2
QEMRLSVNTKPRIHM	HMCN2	1056	Q8NDA2
HRNPKLMLRRTETMV	PLXNB3	1436	Q9ULL4
MARIHSMTIEAPITK	PDE8A	381	O60658
MARIHSMTIEAPITK	PDE8B	441	O95263
HMLIIRVPSVQLAML	GREB1L	956	Q9C091
IVVMNNLLPRSVKMH	PIP5K1A	241	Q99755
MLKRVVQEHLPLMSE	CXXC5	171	Q7LFL8
TVKMLRTQRPAMVQT	PTPRS	1911	Q13332
HRTLKEILRNPMEAM	APOBEC3F	181	Q8IUX4
RMMVTPVELHKSLNT	CYP24A1	251	Q07973
MMTGPQLITIRKAHL	C16orf96	921	A6NNT2
MMKAILVTLLRRFHV	CYP19A1	446	P11511
VHMRSRLIVMVAPAL	ADCY9	136	O60503
IIPQQMAAHMLRSRS	LYST	2091	Q99698
SRLVIKSMLPHFAMV	MAMLD1	6	Q13495
TLVKIPRMILMYIHS	SLC44A1	451	Q8WWI5
AIAIERHLTMIKMRP	S1PR3	131	Q99500
EIQHMITRIPKMLTA	MTERF3	311	Q96E29
PKIEINLSTRMDHMV	NLRP3	651	Q96P20
LVRHMESRIMIPLKI	NIPSNAP1	266	Q9BPW8
IPAEVQMSVKEHIMR	SYT6	141	Q5T7P8
SSEILMMFQQVHRKP	TRIM37	241	O94972
VQRSKMMHNSLSRLP	RAPGEF6	1536	Q8TEU7
LLRPTMQTLAHDVKM	SUPT20HL1	166	Q3ZLR7
VKLRTMLVRTHMQDL	SEPTIN4	381	O43236
ARTQLPQSMKIMHEI	TRPC4AP	371	Q8TEL6
VVLVVMRTKHMRTPT	TRHR	46	P34981
LVNFSKMRMISHIIR	RASGRF2	1176	O14827
KTMPVAMALLRDVHN	TAF2	751	Q6P1X5
VPKMIVDMQTHSRVI	OR7E24	96	Q6IFN5
VVMNNILPRVVKMHL	PIP5K1C	236	O60331
IRESPQAMHRTMLKD	FAM178B	636	Q8IXR5
MTLKSLHLPMARRNT	PTPN14	656	Q15678
RMTMIRVVSHTSVPL	ST6GALNAC3	121	Q8NDV1
THLVRQIPNTAIMMA	SLC25A36	286	Q96CQ1
TILKQMQVLHPAARM	CCT4	76	P50991
MHPITAERTRMLKIK	PKHD1	3306	P08F94
SKMRMISHIIREIRQ	RASGRF1	1216	Q13972
RMQRIHTGTMSVIVL	MTRF1	271	O75570
MLRIPEKKNIMSSRH	STON2	431	Q8WXE9
GNTLMVKVVMVTRHP	SHANK1	746	Q9Y566
MAVNKRTVRMPHQLF	ALDH1L1	411	O75891
MKAQPERMHVLVLSS	CHST4	36	Q8NCG5
MIRLKHLLARVAMTP	PNMA5	286	Q96PV4
AMHSRILRTKPVESM	SLC7A14	21	Q8TBB6
VKTHLRDMIILPEMV	RPS15	76	P62841
MELHIPQKRRTSMSE	STK35	486	Q8TDR2
PHEQKMSVLNMVVRR	TSR1	586	Q2NL82
RMFNKIHKMPTLRRQ	UNC80	2591	Q8N2C7
GKVAERPQHMLMRVS	RRM1	161	P23921
QAIMHMRRTIVKIPS	THEMIS2	211	Q5TEJ8
HMLMRSLNTVALVPI	EZH1	96	Q92800
RMLVKVMHVHSAPVI	HEATR9	316	A2RTY3
KFIPLMIREQRHSAM	RRN3P2	301	A6NIE6
HRVKMIMATNRPDTL	PSMC6	271	P62333
HVAPRMHRLVVMSQV	TBCCD1	301	Q9NVR7
PDLVRIVMKRNPHMT	ZC3H12C	851	Q9C0D7
LRIMMLSVLRNTKTP	UGGT2	1246	Q9NYU1
MELQPVHIIKRMSNA	HIVEP1	511	P15822
STAPLDRLKIMMQVH	SLC25A24	211	Q6NUK1
TLMVQHRMMVPKVRL	UBE3C	431	Q15386
QVIPMVHILNRKVEM	ZBED4	956	O75132