Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	sphingolipid delta-4 desaturase activity	DEGS2 DEGS1	1.47e-05	2	77	2	GO:0042284
GeneOntologyMolecularFunction	L-leucine binding	UBR1 SESN1	3.04e-04	7	77	2	GO:0070728
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	FBH1 MYO1E DDX60 ABCF2 RHOT2 DDX60L AGAP4 AGAP6 ABCA8 DDX3X	7.65e-04	775	77	10	GO:0017111
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	DEGS2 DEGS1	1.11e-03	13	77	2	GO:0016717
GeneOntologyMolecularFunction	pyrophosphatase activity	FBH1 MYO1E DDX60 ABCF2 RHOT2 DDX60L AGAP4 AGAP6 ABCA8 DDX3X	1.39e-03	839	77	10	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	FBH1 MYO1E DDX60 ABCF2 RHOT2 DDX60L AGAP4 AGAP6 ABCA8 DDX3X	1.41e-03	840	77	10	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	FBH1 MYO1E DDX60 ABCF2 RHOT2 DDX60L AGAP4 AGAP6 ABCA8 DDX3X	1.41e-03	840	77	10	GO:0016818
GeneOntologyMolecularFunction	ATP hydrolysis activity	FBH1 MYO1E DDX60 ABCF2 DDX60L ABCA8 DDX3X	1.55e-03	441	77	7	GO:0016887
GeneOntologyMolecularFunction	protein kinase activator activity	CCNT2 MOB3C MOB3B DDX3X	2.64e-03	149	77	4	GO:0030295
GeneOntologyMolecularFunction	amino acid binding	UBR1 GAD2 SESN1	2.82e-03	73	77	3	GO:0016597
GeneOntologyMolecularFunction	helicase activity	FBH1 DDX60 DDX60L DDX3X	3.26e-03	158	77	4	GO:0004386
GeneOntologyMolecularFunction	kinase activator activity	CCNT2 MOB3C MOB3B DDX3X	3.34e-03	159	77	4	GO:0019209
GeneOntologyMolecularFunction	RNA helicase activity	DDX60 DDX60L DDX3X	3.41e-03	78	77	3	GO:0003724
GeneOntologyMolecularFunction	ATP-dependent activity, acting on RNA	DDX60 DDX60L DDX3X	3.66e-03	80	77	3	GO:0008186
GeneOntologyMolecularFunction	enzyme activator activity	DOCK1 CCNT2 MOB3C MOB3B AGAP4 AGAP6 IQGAP3 DDX3X	3.73e-03	656	77	8	GO:0008047
GeneOntologyCellularComponent	acrosomal matrix	DLD C4BPA	1.33e-04	5	77	2	GO:0043159
Domain	DES1/DES2	DEGS2 DEGS1	1.68e-05	2	77	2	IPR011388
Domain	Lipid_DES	DEGS2 DEGS1	1.68e-05	2	77	2	PF08557
Domain	Sphingolipid_d4-desaturase_N	DEGS2 DEGS1	1.68e-05	2	77	2	IPR013866
Domain	Lipid_DES	DEGS2 DEGS1	1.68e-05	2	77	2	SM01269
Domain	Mob1_phocein	MOB3C MOB3B	3.48e-04	7	77	2	PF03637
Domain	MOB_kinase_act_fam	MOB3C MOB3B	3.48e-04	7	77	2	IPR005301
Domain	-	MOB3C MOB3B	3.48e-04	7	77	2	1.20.140.30
Domain	Mob1_phocein	MOB3C MOB3B	3.48e-04	7	77	2	SM01388
Domain	FA_desaturase_dom	DEGS2 DEGS1	4.62e-04	8	77	2	IPR005804
Domain	FA_desaturase	DEGS2 DEGS1	4.62e-04	8	77	2	PF00487
Domain	Pyridoxal_deC	GAD2 SGPL1	4.62e-04	8	77	2	PF00282
Domain	DDC_GAD_HDC_YDC	GAD2 SGPL1	4.62e-04	8	77	2	PS00392
Domain	PyrdxlP-dep_de-COase	GAD2 SGPL1	4.62e-04	8	77	2	IPR002129
Domain	A2M_N_2	A2ML1 C5	4.62e-04	8	77	2	SM01359
Domain	-	A2ML1 C5	4.62e-04	8	77	2	2.60.40.690
Domain	A2M_recep	A2ML1 C5	4.62e-04	8	77	2	SM01361
Domain	A2M	A2ML1 C5	4.62e-04	8	77	2	SM01360
Domain	A2M_N	A2ML1 C5	7.39e-04	10	77	2	PF01835
Domain	A2M_N	A2ML1 C5	7.39e-04	10	77	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	A2ML1 C5	7.39e-04	10	77	2	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	A2ML1 C5	7.39e-04	10	77	2	PS00477
Domain	A2M	A2ML1 C5	7.39e-04	10	77	2	PF00207
Domain	A2M_N_2	A2ML1 C5	7.39e-04	10	77	2	IPR011625
Domain	A2M_comp	A2ML1 C5	7.39e-04	10	77	2	IPR011626
Domain	A2M_N_2	A2ML1 C5	7.39e-04	10	77	2	PF07703
Domain	A2M_recep	A2ML1 C5	7.39e-04	10	77	2	PF07677
Domain	A2M_comp	A2ML1 C5	7.39e-04	10	77	2	PF07678
Domain	Macroglobln_a2	A2ML1 C5	7.39e-04	10	77	2	IPR001599
Domain	-	A2ML1 C5	1.08e-03	12	77	2	1.50.10.20
Domain	Ferritin-like_SF	MOB3C MOB3B	1.48e-03	14	77	2	IPR009078
Domain	MAM_1	MAMDC2 MDGA1	1.94e-03	16	77	2	PS00740
Domain	MAM	MAMDC2 MDGA1	2.19e-03	17	77	2	SM00137
Domain	MAM	MAMDC2 MDGA1	2.46e-03	18	77	2	PF00629
Domain	MAM_dom	MAMDC2 MDGA1	2.46e-03	18	77	2	IPR000998
Domain	MAM_2	MAMDC2 MDGA1	2.46e-03	18	77	2	PS50060
Domain	Terpenoid_cyclase/PrenylTrfase	A2ML1 C5	2.46e-03	18	77	2	IPR008930
Domain	DEAD/DEAH_box_helicase_dom	DDX60 DDX60L DDX3X	3.41e-03	73	77	3	IPR011545
Domain	DEAD	DDX60 DDX60L DDX3X	3.41e-03	73	77	3	PF00270
Domain	NTR	TIMP4 C5	4.01e-03	23	77	2	PS50189
Domain	Netrin_domain	TIMP4 C5	4.01e-03	23	77	2	IPR001134
Domain	TIMP-like_OB-fold	TIMP4 C5	5.11e-03	26	77	2	IPR008993
Domain	ArfGap	AGAP4 AGAP6	6.34e-03	29	77	2	SM00105
Domain	ArfGap	AGAP4 AGAP6	6.34e-03	29	77	2	PF01412
Domain	ARFGAP	AGAP4 AGAP6	6.34e-03	29	77	2	PS50115
Domain	ArfGAP	AGAP4 AGAP6	6.34e-03	29	77	2	IPR001164
Pathway	WP_SPHINGOLIPID_METABOLISM_OVERVIEW	SGPL1 DEGS2 DEGS1	8.60e-05	25	49	3	MM15931
Pathway	WP_SPHINGOLIPID_METABOLISM_INTEGRATED_PATHWAY	SGPL1 DEGS2 DEGS1	9.70e-05	26	49	3	M39784
Pathway	WP_SPHINGOLIPID_METABOLISM_INTEGRATED_PATHWAY	SGPL1 DEGS2 DEGS1	9.70e-05	26	49	3	MM15892
Pathway	WP_SPHINGOLIPID_METABOLISM_OVERVIEW	SGPL1 DEGS2 DEGS1	1.09e-04	27	49	3	M39863
Pathway	KEGG_SPHINGOLIPID_METABOLISM	SGPL1 DEGS2 DEGS1	3.30e-04	39	49	3	M15955
Pubmed	Identification and characterization of a sphingolipid delta 4-desaturase family.	DEGS2 DEGS1	4.97e-06	2	78	2	11937514
Pubmed	Dihydroceramide-based response to hypoxia.	DEGS2 DEGS1	4.97e-06	2	78	2	21914808
Pubmed	Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and Timp4 genes to human chromosome 3p25 and mouse chromosome 6, respectively.	TIMP4 DDX3X	1.49e-05	3	78	2	9693046
Pubmed	ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.	COPA MYO1E TTC28 ATG2B ABCF2 DDX3X	3.20e-05	268	78	6	33024031
Pubmed	ZFP750 affects the cutaneous barrier through regulating lipid metabolism.	SGPL1 DEGS2 DEGS1	4.66e-05	31	78	3	37115925
Pubmed	The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response.	TBK1 DDX3X	4.94e-05	5	78	2	18583960
Pubmed	Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles.	DOCK1 COPA SGPL1 IQGAP3	4.95e-05	89	78	4	27034005
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	RPL30 COPA MYO1E SGPL1 TBK1 ABCF2 DDX3X RPL19	6.15e-05	601	78	8	33658012
Pubmed	Chromosomal distribution of ribosomal protein genes in the mouse.	RPL30 RPL19	7.40e-05	6	78	2	7237550
Pubmed	Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966.	ZBTB38 TNXB TBX2	7.98e-05	37	78	3	19266077
Pubmed	A genomic atlas of mouse hypothalamic development.	GAD2 EFNB1 PAK3 TENM2 TBX2	1.01e-04	205	78	5	20436479
Pubmed	The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome.	RPL30 RPL19	1.04e-04	7	78	2	1577483
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	UBR1 RPL30 TTC28 SGPL1 TBK1 RBM47 IQGAP3 DDX3X	1.06e-04	650	78	8	38777146
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	TNIK VPS11 TBK1 AGAP4 AGAP6	1.35e-04	218	78	5	33378226
Pubmed	Molecular characterization of human homologs of yeast MOB1.	MOB3C MOB3B	1.38e-04	8	78	2	19739119
Pubmed	Variants in TNFAIP3, STAT4, and C12orf30 loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritis.	NAA25 C5	1.38e-04	8	78	2	19565500
Pubmed	Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3.	TOMM40 TNXB	1.38e-04	8	78	2	22694956
Pubmed	GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.	AGAP4 AGAP6	1.77e-04	9	78	2	12640130
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	DOCK1 COPA TTC28 ATG2B PTPN23 ABCF2 DDX3X RPL19	1.90e-04	708	78	8	39231216
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	DOCK1 RPL30 NAA25 MYO1E RBM6 AGAP4 AGAP6	2.04e-04	536	78	7	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	DOCK1 RPL30 NAA25 MYO1E RBM6 AGAP4 AGAP6	2.09e-04	538	78	7	10512203
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	UBR1 RPL30 COPA SGPL1 A2ML1 PTPN23 ABCF2 PRMT3 RHOT2 DDX60L RPL19	2.11e-04	1353	78	11	29467282
Pubmed	AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.	AGAP4 AGAP6	2.21e-04	10	78	2	20664521
Pubmed	Genes to diseases (G2D) computational method to identify asthma candidate genes.	DOCK1 FANK1	2.21e-04	10	78	2	18682798
Pubmed	A tumor-associated autoantibody panel for the detection of non-small cell lung cancer.	GAD2 ZNF573	2.21e-04	10	78	2	36531074
Pubmed	Landscape of the SOX2 protein-protein interactome.	RPL30 COPA MYO1E DDX3X	2.55e-04	136	78	4	21280222
Pubmed	Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.	TNIK RPL30 PHPT1 PAK3 TOMM40 DDX3X RPL19	2.60e-04	558	78	7	35063084
Pubmed	AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase.	AGAP4 AGAP6	2.70e-04	11	78	2	15381706
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	RPL30 COPA RBM6 DLD ABCF2 IQGAP3 AGTPBP1 RPL19	3.03e-04	759	78	8	35915203
Pubmed	Many sequence variants affecting diversity of adult human height.	PDE3A ZBTB38 TNXB TBX2	3.09e-04	143	78	4	18391951
Pubmed	Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides.	A2ML1 C4BPA C5	3.22e-04	59	78	3	17330941
Pubmed	LukS-PV inhibits hepatocellular carcinoma cells migration by downregulating HDAC6 expression.	RPL30 COPA MYO1E DLD TDRD6 DDX3X RPL19	3.29e-04	580	78	7	35676659
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	RPL30 COPA TBK1 DLD ABCF2 TOMM40 PRMT3 TDRD6 IQGAP3 DDX3X RPL19	3.29e-04	1425	78	11	30948266
Pubmed	The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin.	AGAP4 AGAP6	3.81e-04	13	78	2	27713690
Pubmed	Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.	TDRD6 SPATA4	4.44e-04	14	78	2	17662146
Pubmed	GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.	AGAP4 AGAP6	4.44e-04	14	78	2	22453919
Pubmed	A Noncanonical Role of Fructose-1, 6-Bisphosphatase 1 Is Essential for Inhibition of Notch1 in Breast Cancer.	RPL30 COPA MYO1E DDX3X RPL19	4.70e-04	286	78	5	32041737
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	RPL30 COPA MYO1E SGPL1 DDX60 ABCF2 TOMM40 IQGAP3 DDX3X RPL19	4.96e-04	1257	78	10	36526897
Pubmed	PARK2 promotes mitochondrial pathway of apoptosis and antimicrotubule drugs chemosensitivity via degradation of phospho-BCL-2.	RPL30 COPA ABCF2 DDX3X RPL19	5.00e-04	290	78	5	32929329
Pubmed	Git1-PGK1 interaction achieves self-protection against spinal cord ischemia-reperfusion injury by modulating Keap1/Nrf2 signaling.	COPA PAK3	5.12e-04	15	78	2	36963288
Pubmed	Comparative Proteomics and Interactome Analysis of the SARS-CoV-2 Nucleocapsid Protein in Human and Bat Cell Lines.	RPL30 COPA DDX3X RPL19	5.67e-04	168	78	4	39066279
Pubmed	Genetic influences on the end-stage effector phase of arthritis.	C4BPA C5	5.84e-04	16	78	2	11489951
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	GAD2 NAA25 ZBTB38 FBH1 COPA MYO1E TTC28 CADPS2 DDX3X AGTPBP1	5.88e-04	1285	78	10	35914814
Pubmed	High-sensitivity profiling of SARS-CoV-2 noncoding region-host protein interactome reveals the potential regulatory role of negative-sense viral RNA.	COPA SGPL1 DDX60 RBM47 DDX3X RPL19	6.59e-04	469	78	6	37314180
Pubmed	PDGF signaling specificity is mediated through multiple immediate early genes.	MYO1E SGPL1	6.61e-04	17	78	2	17143286
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	RPL30 SGPL1 DLD ABCF2 DDX3X TBX2 RPL19	6.77e-04	655	78	7	35819319
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	TNIK VPS11 COPA MYO1E SGPL1	7.06e-04	313	78	5	38270169
Pubmed	The nuclear import of the small GTPase Rac1 is mediated by the direct interaction with karyopherin alpha2.	IQGAP3 DDX3X	7.42e-04	18	78	2	19961560
Pubmed	RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma.	CCNT2 MYO1E RBM6 RPL19	7.81e-04	183	78	4	28186131
Pubmed	Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair.	MYO1E SGPL1 ABCA8 DDX3X RPL19	7.90e-04	321	78	5	32098917
Pubmed	LOXL2 Upregulates Phosphorylation of Ezrin to Promote Cytoskeletal Reorganization and Tumor Cell Invasion.	RPL30 COPA A2ML1 ABCF2 DDX3X	8.58e-04	327	78	5	31409639
Pubmed	Fine mapping of collagen-induced arthritis quantitative trait loci in an advanced intercross line.	UBR1 C5	9.19e-04	20	78	2	17082620
Pubmed	NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90.	RPL30 MYO1E DLD DDX3X RPL19	9.31e-04	333	78	5	32665550
Pubmed	HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis.	COPA TTC28 IQGAP3	1.00e-03	87	78	3	33711283
Pubmed	EEF1D Promotes Glioma Proliferation, Migration, and Invasion through EMT and PI3K/Akt Pathway.	MYO1E DDX3X	1.01e-03	21	78	2	33029523
Pubmed	Structural snapshots of actively translating human ribosomes.	RPL30 RPL19	1.01e-03	21	78	2	25957688
Pubmed	Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.	TNXB CASZ1	1.01e-03	21	78	2	25249183
Pubmed	Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags.	EFNB1 MYO1E MOB3B POMGNT1 RBM47 DDX3X	1.02e-03	510	78	6	16712791
Pubmed	PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.	FBH1 COPA MYO1E DDX3X RPL19	1.02e-03	340	78	5	24332808
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	TNIK COPA PTPN23 PRMT3 RHOT2 IQGAP3 DDX3X	1.03e-03	704	78	7	29955894
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	TTC28 ATG2B DEGS2 MINDY2 AGAP4 AGTPBP1	1.05e-03	513	78	6	25798074
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	DOCK1 COPA DDX60 IQGAP3	1.13e-03	202	78	4	33005030
Pubmed	Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature.	TIMP4 TBX2	1.22e-03	23	78	2	23117660
Pubmed	Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus.	ABCF2 ABCA8	1.22e-03	23	78	2	10708515
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	TNIK TTC28 ATG2B PRMT3	1.28e-03	209	78	4	36779422
Pubmed	Discovery and refinement of loci associated with lipid levels.	PDE3A AOC1 A2ML1 ABCA8	1.32e-03	211	78	4	24097068
Pubmed	A proteomics approach for the identification of cullin-9 (CUL9) related signaling pathways in induced pluripotent stem cell models.	COPA DDX3X	1.33e-03	24	78	2	33705438
Pubmed	CRISPR/Cas9-mediated Genomic Editing of Cluap1/IFT38 Reveals a New Role in Actin Arrangement.	EFNB1 TOMM40 CADPS2 IQGAP3	1.37e-03	213	78	4	29615496
Pubmed	Proteomic dissection of the von Hippel-Lindau (VHL) interactome.	RPL30 PRMT3 DDX3X	1.42e-03	98	78	3	21942715
Pubmed	Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex.	COPA ABCF2 IQGAP3 DDX3X	1.42e-03	215	78	4	30462309
Pubmed	Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development.	GAD2 CADPS2	1.44e-03	25	78	2	30718509
Pubmed	Integrated proteogenetic analysis reveals the landscape of a mitochondrial-autophagosome synapse during PARK2-dependent mitophagy.	TBK1 ATG2B TOMM40	1.46e-03	99	78	3	31723608
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	RPL30 COPA SGPL1 POMGNT1 DLD PTPN23 ABCF2 DEGS1 DDX3X RPL19	1.48e-03	1451	78	10	30550785
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	RPL30 PDE3A COPA MYO1E DLD PTPN23 ABCF2 PRMT3 DDX3X RPL19	1.51e-03	1455	78	10	22863883
Pubmed	Foxn4 is a temporal identity factor conferring mid/late-early retinal competence and involved in retinal synaptogenesis.	GAD2 CASZ1	1.56e-03	26	78	2	32071204
Pubmed	Identification of 15 loci influencing height in a Korean population.	ZBTB38 TBX2	1.68e-03	27	78	2	19893584
Pubmed	Genome-wide association studies and heritability estimates of body mass index related phenotypes in Bangladeshi adults.	RBM47 TENM2	1.68e-03	27	78	2	25133637
Pubmed	BMP receptor 1b is required for axon guidance and cell survival in the developing retina.	EFNB1 TBX2	1.68e-03	27	78	2	12654290
Pubmed	Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil.	DEGS2 DEGS1	1.68e-03	27	78	2	25269881
Pubmed	Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.	RPL30 PHPT1 POMGNT1 DLD PTPN23 RHOT2	1.84e-03	573	78	6	28330616
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	UBR1 CCNT2 RPL30 COPA TBK1 DLD ABCF2 DDX3X RPL19	1.89e-03	1247	78	9	27684187
Pubmed	Single-cell transcriptomic landscapes of the otic neuronal lineage at multiple early embryonic ages.	CASZ1 TBX2	2.07e-03	30	78	2	35320729
Pubmed	Methylation of the DNA/RNA-binding protein Kin17 by METTL22 affects its association with chromatin.	DDX3X RPL19	2.07e-03	30	78	2	24140279
Pubmed	Nuclear organization of nucleotide excision repair is mediated by RING1B dependent H2A-ubiquitylation.	COPA DDX3X RPL19	2.07e-03	112	78	3	28416769
Pubmed	Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.	EFNB1 DLD CADPS2 AGAP4 AGAP6	2.20e-03	405	78	5	38187761
Pubmed	Risk of non-Hodgkin lymphoma in association with germline variation in complement genes.	C4BPA C5	2.21e-03	31	78	2	19344414
Pubmed	FBXW7 Reduces the Cancer Stem Cell-Like Properties of Hepatocellular Carcinoma by Regulating the Ubiquitination and Degradation of ACTL6A.	TOMM40 DDX3X	2.21e-03	31	78	2	36159747
Cytoband	4q32.3	DDX60 DDX60L	1.54e-03	34	78	2	4q32.3
Cytoband	14q32.2	ATG2B DEGS2	1.93e-03	38	78	2	14q32.2
GeneFamily	MOB kinase activators\|STRIPAK complex	MOB3C MOB3B	1.96e-04	7	56	2	647
GeneFamily	Fatty acid desaturases	DEGS2 DEGS1	2.61e-04	8	56	2	553
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	A2ML1 C5	3.35e-04	9	56	2	1234
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	AGAP4 AGAP6	1.24e-03	17	56	2	1291
Coexpression	GSE17721_CTRL_VS_LPS_24H_BMDC_UP	UBR1 RPL30 MYO1E SESN1 IQGAP3 DDX3X	2.90e-05	199	78	6	M3703
Coexpression	GSE9960_GRAM_NEG_VS_GRAM_NEG_AND_POS_SEPSIS_PBMC_DN	ZNF573 PHPT1 PRMT3 AASDH KIAA1586 AGTPBP1	2.90e-05	199	78	6	M7131
Coexpression	GSE21546_WT_VS_SAP1A_KO_AND_ELK1_KO_DP_THYMOCYTES_DN	TNIK SEMA3D TTC28 MAMDC2 RBM47 SESN1	2.98e-05	200	78	6	M7518
ToppCell	COVID-19-Heart-CM_1\|Heart / Disease (COVID-19 only), tissue and cell type	TNIK PDE3A NRAP SPHKAP PLCXD3 TENM2 CASZ1	5.25e-08	195	78	7	f1ef50331eda8f1239dba6ea970df4eaccf032f1
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|RV / Chamber and Cluster_Paper	TNIK SPHKAP PLCXD3 TENM2 SESN1 CASZ1	1.01e-06	189	78	6	9c1debd65c13d63fd4f3158917d621b44b714c26
ToppCell	COVID-19-Heart\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PDE3A NRAP SPHKAP PLCXD3 TENM2 ABCA8	1.05e-06	190	78	6	918ad5037881212008f9f69d5df5da91fd01422c
ToppCell	COVID-19-Heart-CM_2\|Heart / Disease (COVID-19 only), tissue and cell type	PDE3A NRAP SPHKAP PLCXD3 TENM2 CASZ1	1.22e-06	195	78	6	75fc81bddb246dca3b437fb60827b1d4fe416405
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PDE3A MAMDC2 PAK3 TENM2 TNXB TBX2	1.29e-06	197	78	6	6d0d68d460243a0259ada93ebda40fa7b3088eeb
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SEMA3D PDE3A PAK3 PLCXD3 TNXB ABCA8	1.41e-06	200	78	6	74e74123ea7bf38d337a3a0248a6a51437c6ab42
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Dedifferentiated_Liposarcoma-4\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	TIMP4 C4BPA SESN1 TNXB ABCA8	1.41e-05	175	78	5	16849ea8f0985108baa2085f34c3de14a4f9f28b
ToppCell	COVID-19-Heart-CM_3\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PDE3A NRAP PLCXD3 DDX60L TENM2	1.45e-05	176	78	5	9df7a124ebafb0087da0cda133a394275d7bed81
ToppCell	(3)_Chondrocytes-(32)_Chondro-prehyper-2\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	SEMA3D PDE3A CNMD PAK3 TENM2	1.53e-05	178	78	5	c569a406c3ae183a278d8540e8eba58f4f26c5b0
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SEMA3D PDE3A MAMDC2 TNXB ABCA8	1.62e-05	180	78	5	08ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SEMA3D PDE3A MAMDC2 TNXB ABCA8	1.62e-05	180	78	5	9b1de1b4711adbf9a423f4d2d08f3f4c78f1f8f4
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PDE3A NRAP SPHKAP PLCXD3 TENM2	1.66e-05	181	78	5	719eb532453ab7cd7893726885bc75d74a10b21e
ToppCell	COVID-19-Heart-CM_3\|Heart / Disease (COVID-19 only), tissue and cell type	TNIK PDE3A NRAP DDX60L TENM2	1.70e-05	182	78	5	287fcc3897ae08841f6f85ae6c9cef16f75b1dd1
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE3A MAMDC2 SPHKAP PAK3 TNXB	1.75e-05	183	78	5	7eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCell	COVID-19-Heart-CM_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PDE3A NRAP SPHKAP PLCXD3 TENM2	1.80e-05	184	78	5	e737f0f14c49b07bbb04a165083ac32210bc5690
ToppCell	COVID-19-Heart-CM_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PDE3A NRAP SPHKAP PLCXD3 TENM2	1.84e-05	185	78	5	549eeb521c3985bff396ea0f202db21822efa51f
ToppCell	Control-Epithelial_alveolar-AT_2-Differentiating_AT2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SPHKAP C4BPA C5 CADPS2 RBM47	1.84e-05	185	78	5	0d2add28ac1f4fa6de7699be009bf8391badaf4c
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	PDE3A NRAP SPHKAP PLCXD3 TENM2	1.84e-05	185	78	5	6baccb26f999145e51b91d94315bf8d4655bef31
ToppCell	Control-Fibroblasts-Other_FB\|Control / group, cell type (main and fine annotations)	PDE3A MAMDC2 TENM2 TNXB TBX2	1.94e-05	187	78	5	bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|World / Chamber and Cluster_Paper	TNIK SPHKAP PLCXD3 TENM2 CASZ1	1.94e-05	187	78	5	78cdcf8bc141d3b155c3c8af908431fc419c4d08
ToppCell	Control-Fibroblasts-Adventitial_FB\|Control / group, cell type (main and fine annotations)	SEMA3D PDE3A PAK3 TNXB ABCA8	1.99e-05	188	78	5	706a26c372add839d947749f0521a0e1f5c9b0ec
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	PDE3A SPHKAP PLCXD3 TENM2 CASZ1	2.04e-05	189	78	5	5e80c47f63980904c4c1ff02c201b67b456a0974
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	TNIK PDE3A SPHKAP PLCXD3 TENM2	2.10e-05	190	78	5	de5ef606a002f85c2e0e3a36c1f259d0b85a76ff
ToppCell	PCW_13-14\|World / Celltypes from embryonic and fetal-stage human lung	TNIK SEMA3D ZBTB38 ABCA8 TBX2	2.10e-05	190	78	5	62a3ec1ae0829602b0569cc051210551644f1d46
ToppCell	Control-Fibroblasts\|Control / group, cell type (main and fine annotations)	PDE3A MAMDC2 TNXB ABCA8 TBX2	2.10e-05	190	78	5	3a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|RV / Chamber and Cluster_Paper	PDE3A SPHKAP PLCXD3 TENM2 CASZ1	2.10e-05	190	78	5	fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCell	Control-Stromal_mesenchymal\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SEMA3D PDE3A MAMDC2 PAK3 TNXB	2.15e-05	191	78	5	14057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|LV / Chamber and Cluster_Paper	TNIK NRAP SPHKAP PLCXD3 TENM2	2.20e-05	192	78	5	ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	TNIK PDE3A NRAP PLCXD3 TENM2	2.26e-05	193	78	5	dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D231\|Adult / Lineage, Cell type, age group and donor	MAMDC2 TENM2 TNXB ABCA8 TBX2	2.26e-05	193	78	5	ef2f456c094e6e3c6ee81e0668c953cb8d0e1c0a
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SEMA3D PDE3A PAK3 TNXB ABCA8	2.26e-05	193	78	5	9ab47b360bee1d4f1092c2269e58acebe9584021
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM1_(8)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	SPHKAP CADPS2 CASZ1 TBX2 RPL19	2.26e-05	193	78	5	e2b455387d1de7812305200a2041a0f4759a6f54
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TNIK TTC28 TENM2 ABCA8 TBX2	2.32e-05	194	78	5	011e14d9ed1393275f892060e7708ffadcd0767f
ToppCell	COVID-19-Fibroblasts-Alveolar_FB\|COVID-19 / group, cell type (main and fine annotations)	TTC28 MAMDC2 TNXB ABCA8 TBX2	2.37e-05	195	78	5	603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A PAK3 PLCXD3 TNXB ABCA8	2.37e-05	195	78	5	3c3703f092b6fc1b7333426fb5e2823bfb74bb57
ToppCell	Children_(3_yrs)-Mesenchymal\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PDE3A MAMDC2 TNXB ABCA8 TBX2	2.43e-05	196	78	5	bc94909f9b2dc08a59eef1914148b69720569c8f
ToppCell	Control_saline-Epithelial_alveolar-AT_2-Differentiating_AT2\|Control_saline / Treatment groups by lineage, cell group, cell type	TNIK SPHKAP C5 CADPS2 RBM47	2.49e-05	197	78	5	44a59dfb889577b3160a5b13ada1276771a00241
ToppCell	Bronchial-NucSeq-Stromal-Peri/Epineurial_-NAF_epineurial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SEMA3D PDE3A EFNB1 PAK3 TENM2	2.49e-05	197	78	5	dfeb4a0eb4dfba90f4a3e6ba31e0ab0e4aba5849
ToppCell	tumor_Lung-Fibroblasts-COL13A1+_matrix_FBs\|Fibroblasts / Location, Cell class and cell subclass	RPL30 MAMDC2 TNXB ABCA8 TBX2	2.49e-05	197	78	5	44f37a98f07c3e46a7e8fd3b64c2b2b44d5bbe40
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	TNIK SEMA3D SPHKAP CADPS2 ABCA8	2.49e-05	197	78	5	0034bae02ee7fcfea520d453ca3c842ab6963b12
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	TNIK SEMA3D TTC28 ABCA8 TBX2	2.55e-05	198	78	5	17dc055e2a289496d9c5cdbf3297bdf906dc6d22
ToppCell	Adult-Mesenchymal\|Adult / Lineage, Cell type, age group and donor	PDE3A MAMDC2 TNXB ABCA8 TBX2	2.55e-05	198	78	5	26e55b409db2a1637c95fae7c54b0abea1ef550c
ToppCell	Fetal_29-31_weeks-Mesenchymal\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SEMA3D PDE3A TTC28 ABCA8 TBX2	2.55e-05	198	78	5	21cf4d81386761d09d0f6829c01c198e5524176d
ToppCell	Mesenchymal\|World / Lineage, Cell type, age group and donor	PDE3A TTC28 TNXB ABCA8 TBX2	2.61e-05	199	78	5	4bac110c2b3609f6ee5d0e3275da0824a6240270
ToppCell	Parenchymal-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PDE3A MAMDC2 TNXB ABCA8 TBX2	2.68e-05	200	78	5	cf433f9b43d7db07acaf70e060f8f77c974e72f3
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PDE3A MAMDC2 TNXB ABCA8 TBX2	2.68e-05	200	78	5	311fab076f2ceb258e3970eb21e39344b894042a
ToppCell	(15)_Treg\|World / shred on Cell_type and subtype	TNIK RPL30 FANK1 SESN1 RPL19	3.16e-05	207	78	5	83bae0389269077434d1e5ab53205ae569ff4479
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE3A MAMDC2 TNXB ABCA8	6.91e-05	125	78	4	b162a5bfbb8ac5e65e13578fef9de442a9e4fd8b
ToppCell	Control-Plasmablast\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	ZBTB38 FBH1 GPR55 RBM47	1.23e-04	145	78	4	fe68582f5a15b9714cb84fa32ac880e13cb69895
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A PAK3 PLCXD3 ABCA8	1.23e-04	145	78	4	051d964ff6bdc12ba3f0459d3e6ab16fa9507b0b
ToppCell	367C-Lymphocytic-CD4_T-cell-Treg_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	FANK1 PHPT1 PLAGL2 IQGAP3	1.47e-04	152	78	4	6d02b50e9e9ecf820f84a79e46d153a4840a1cfe
ToppCell	metastatic_Brain-Fibroblasts-Smooth_muscle_cells\|Fibroblasts / Location, Cell class and cell subclass	C9orf43 NAA25 PAK3 CASZ1	1.55e-04	154	78	4	423f58fc7dcef068458cbf7b4ee989e37227041e
ToppCell	Children_(3_yrs)-Mesenchymal-chondrocyte\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TIMP4 MAMDC2 ABCA8 TBX2	1.67e-04	157	78	4	f147e24f2ece82e1c54750868954d09b3c461804
ToppCell	Healthy/Control-Treg\|Healthy/Control / Disease group and Cell class	C9orf43 FANK1 ZBTB25 GPR55	1.75e-04	159	78	4	16a322760c99f3e2c3b73cbb399f77868951d3cb
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A MOB3C PLCXD3 ABCA8	1.75e-04	159	78	4	e812cbde59188924c6277c3feadf1a9592fa62a4
ToppCell	Adult-Mesenchymal-chondrocyte\|Adult / Lineage, Cell type, age group and donor	MAMDC2 PAK3 TNXB TBX2	1.75e-04	159	78	4	3f7305ee76447064b5c846c4f576360a2f7e0b7c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A MOB3C PLCXD3 ABCA8	1.75e-04	159	78	4	2607b562903228274fbd96168ba826782fab0b53
ToppCell	PND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SEMA3D MAMDC2 SPHKAP TENM2	1.79e-04	160	78	4	8624f101828efd32cdd38a65df8d94d690720a63
ToppCell	PND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SEMA3D MAMDC2 SPHKAP TENM2	1.79e-04	160	78	4	9de3dd6b9d4b51314d60b3b01f4132bcfa2dfc18
ToppCell	Healthy/Control-Treg\|World / Disease group and Cell class	C9orf43 FANK1 ZBTB25 GPR55	1.83e-04	161	78	4	457297cda5c9cee3bcc069fdecbbe24def027e5f
ToppCell	normal_Lung-Myeloid_cells-Undetermined\|Myeloid_cells / Location, Cell class and cell subclass	GPR55 C5 ZNF891 SPATA4	1.83e-04	161	78	4	283012858e575c70d09950de53da041509f59bfa
ToppCell	droplet-Marrow-nan-21m-Hematologic-erythroid_progenitor\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1E GPR55 PRMT3 AASDH	1.88e-04	162	78	4	d0ffebf5adee8a3ac9b81a4b793184f54010489a
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26-Neuronal-Interneuron\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	GAD2 SEMA3D MOB3B	1.94e-04	64	78	3	fefabdf8d72a8f3caf78eb79d759edb475bdb2ad
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_B_(ET)-Glut_ET_L5_FEZF2-Exc_L3-5_FEZF2_DCN\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SEMA3D DDX60 SPHKAP DDX60L	2.01e-04	165	78	4	aad0ab96d9d4387edfcef2b114346a030eb4b021
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_B_(ET)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SEMA3D DDX60 SPHKAP DDX60L	2.16e-04	168	78	4	8e9046b661642293eee640ead91d43db9d8daae0
ToppCell	TCGA-Colorectal-Solid_Tissue_Normal-Rectum_normal_tissue-Rectum_normal_tissue-6\|TCGA-Colorectal / Sample_Type by Project: Shred V9	NRAP MAMDC2 TNXB ABCA8	2.16e-04	168	78	4	5ce3129a023a48a3d7e6b9306c1fc5addfef9675
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_B_(ET)-Glut_ET_L5_FEZF2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SEMA3D DDX60 SPHKAP DDX60L	2.16e-04	168	78	4	c7d66e5d9311ceaab3f144f1516b49b8812976b8
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_B_(ET)-Glut_ET_L5_FEZF2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SEMA3D DDX60 SPHKAP DDX60L	2.21e-04	169	78	4	d0c64ca31053dfc283a07d5ad1117ca7dc1777a7
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_B_(ET)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SEMA3D DDX60 SPHKAP DDX60L	2.21e-04	169	78	4	d79abfbeffd082a4fbffbc1051ffc474374874fa
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A PLCXD3 TNXB ABCA8	2.26e-04	170	78	4	fa753cc8fbd04e63c9a303da4dc17ee2ce907f92
ToppCell	COVID-19-Heart-CM_+_Macrophage\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PDE3A NRAP PLCXD3 TENM2	2.26e-04	170	78	4	3f15242a1d3e4e9871d9170b2ef05842fb609c29
ToppCell	COVID-19-Heart-CM_+_Macrophage\|Heart / Disease (COVID-19 only), tissue and cell type	NRAP DDX60L RBM47 TENM2	2.26e-04	170	78	4	4232fe937909f93d3736988c707b8f95ce993398
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L6_LHX6_GLP1R\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GAD2 SEMA3D PDE3A PLCXD3	2.26e-04	170	78	4	40675b55269ffa57fb7fcdb903c81b02b4e01f8f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A PLCXD3 TNXB ABCA8	2.26e-04	170	78	4	03044e1436443b28dd39d5ef4fdb25c18e3a7546
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A PLCXD3 TNXB ABCA8	2.31e-04	171	78	4	5d31fc9b60329d4ae3c77e4ca679359d9314397d
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SEMA3D MAMDC2 SPHKAP TENM2	2.31e-04	171	78	4	82de2885c8ce4fb7776da6a0207b3355c0910121
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SEMA3D MAMDC2 SPHKAP TENM2	2.31e-04	171	78	4	09e653973962fb884878089d281f0947f7a285f6
ToppCell	-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	MAMDC2 TNXB ABCA8 TBX2	2.41e-04	173	78	4	88be9182fbb1bc83531cd41e59ea57c112a21d54
ToppCell	TCGA-Breast-Solid_Tissue_Normal-Breast_normal_tissue-Breast_normal_tissue-3\|TCGA-Breast / Sample_Type by Project: Shred V9	KY MAMDC2 TNXB ABCA8	2.47e-04	174	78	4	7f8f5fafae08676d2b90cab9802c3c9320f1370e
ToppCell	TCGA-Breast-Solid_Tissue_Normal\|TCGA-Breast / Sample_Type by Project: Shred V9	KY MAMDC2 TNXB ABCA8	2.47e-04	174	78	4	e2f240d60bffbe8e6d60f0bb405b231bd3c96875
ToppCell	TCGA-Breast-Solid_Tissue_Normal-Breast_normal_tissue-Breast_normal_tissue\|TCGA-Breast / Sample_Type by Project: Shred V9	KY MAMDC2 TNXB ABCA8	2.47e-04	174	78	4	0f3ec0d0d4344e10c9b48adc9174123f6402dc51
ToppCell	TCGA-Breast-Solid_Tissue_Normal-Breast_normal_tissue\|TCGA-Breast / Sample_Type by Project: Shred V9	KY MAMDC2 TNXB ABCA8	2.47e-04	174	78	4	1aadbf2642b6d1320ceabd92e6ff59e11f16c315
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L6_LAMP5_C1QL2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GAD2 SPHKAP PLCXD3 MDGA1	2.52e-04	175	78	4	4d42a97c450e919a409477a7db85e2668f0d473b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A PLCXD3 TNXB ABCA8	2.52e-04	175	78	4	795a6564d5a75ffd35d39f5274b9e8d28708bbc8
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-COL13A1+_matrix_FBs\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	MAMDC2 TNXB ABCA8 TBX2	2.58e-04	176	78	4	510f9a14dc1c151d24d079e0cc004cdf4f86336c
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SEMA3D FUT10 MAMDC2 IQGAP3	2.63e-04	177	78	4	3e149bff1f1b393a7abe98984e37981c8296f95d
ToppCell	droplet-Heart-nan-3m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KY PDE3A MAMDC2 TBX2	2.63e-04	177	78	4	dbdbdc8ed9ef0b529694242ef9f9f07a42e16005
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-K_cells_(GIP+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GAD2 PAK3 PLCXD3 RBM47	2.63e-04	177	78	4	43dce527392f3b8364bb6a55268ce9d6518d3a29
ToppCell	droplet-Heart-nan-3m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KY PDE3A MAMDC2 TBX2	2.69e-04	178	78	4	416f85e51f45ec7949451fd47611a84e33e87245
ToppCell	facs-Heart-LV-3m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KY PDE3A MAMDC2 TBX2	2.75e-04	179	78	4	8da6863edc756540bb097cc7221c1408640d9bb4
ToppCell	-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	MAMDC2 SPHKAP ABCA8 TBX2	2.75e-04	179	78	4	10fadbaa1b6d21cbf9f354d717cc4c225619f4fd
ToppCell	facs-Heart-LV-3m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KY PDE3A MAMDC2 TBX2	2.75e-04	179	78	4	f39c13c99a07d009cc677e363ffe089089c64916
ToppCell	390C-Lymphocytic-ILC-ILC-1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	FUT10 FANK1 EFNB1 PRMT3	2.75e-04	179	78	4	3edcd1356e49b1f5514c585861999e079ca5e579
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MAMDC2 SPHKAP PAK3 TNXB	2.75e-04	179	78	4	02c90d8306016365ed811f0c63cfb3ac7b85464c
ToppCell	LV\|World / Chamber and Cluster_Paper	TNIK SPHKAP PLCXD3 TENM2	2.81e-04	180	78	4	5ac6f485a58bb29462fec02dfbe8eb70864eafe3
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SPHKAP MOB3B PLCXD3 CADPS2	2.81e-04	180	78	4	8923a42a6db9c6e9f3ce2ca9530e620dfea700ba
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK1 EFNB1 POMGNT1 RBM47	2.81e-04	180	78	4	be10fe5bf7c3a671c42704ce7dd8226ab6896794
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK1 EFNB1 POMGNT1 RBM47	2.81e-04	180	78	4	3b747a517ce75ef2ff09011c037dad7b01ed3e03
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYO1E CADPS2 CASZ1 TBX2	2.81e-04	180	78	4	788d5fbf688365b5d92d3aa19b9f8e9448f8be5a
ToppCell	Thalamus-Macroglia\|Thalamus / BrainAtlas - Mouse McCarroll V32	FUT10 TIMP4 CNMD MOB3B	2.87e-04	181	78	4	4f62b63854a4e9fea6e839f0340e78392c66fb0e
Drug	Clemizole hydrochloride [1163-36-6]; Down 200; 11uM; PC3; HT_HG-U133A	TNIK COPA TTC28 PAK3 CASZ1 DDX3X TBX2	4.48e-06	193	78	7	3672_DN
Drug	nifedipine; Down 200; 10uM; MCF7; HG-U133A	DOCK1 CNMD ATG2B PAK3 ABCF2 MINDY2 DEGS1	5.48e-06	199	78	7	603_DN
Disease	hypertension	PDE3A MOB3C RBM47 TNXB CASZ1 TBX2	1.33e-04	307	75	6	EFO_0000537
Disease	urate measurement, bone density	TTC28 A2ML1 RBM6 CADPS2 TENM2 TNXB ABCA8 CASZ1	1.76e-04	619	75	8	EFO_0003923, EFO_0004531
Disease	cerebral palsy (implicated_via_orthology)	AGAP4 AGAP6	2.83e-04	10	75	2	DOID:1969 (implicated_via_orthology)
Disease	neurodegenerative disease (implicated_via_orthology)	UBR1 RHOT2 DEGS2 DEGS1	5.19e-04	145	75	4	DOID:1289 (implicated_via_orthology)
Disease	level of Phosphatidylethanolamine (18:0_20:4) in blood serum	MYO1E MINDY2	1.06e-03	19	75	2	OBA_2045140
Disease	p-tau:beta-amyloid 1-42 ratio measurement	TTC28 TOMM40	1.06e-03	19	75	2	EFO_0007709
Disease	lipoprotein measurement	DOCK1 NAA25 ABCA8	2.45e-03	105	75	3	EFO_0004732

Protein segments in the cluster

Peptide	Gene	Start	Entry
MFLAAIAHHYTFSYK	TMEM184C	301	Q9NVA4
TYYSSLGDYMKNIHK	AGAP4	291	Q96P64
KIAHGHYKQSSSYSF	C4BPA	431	P04003
IHMHNKKLKYYTGNY	ABCF2	296	Q9UG63
HRFYMHHSFTKFNKN	CCNT2	66	O60583
YKFCGRTHMYKHAQH	CASZ1	1466	Q86V15
QKELMYKHSNGSYSA	A2ML1	1011	A8K2U0
YIGSHSHRMKAVDFY	AASDH	786	Q4L235
EAKMHATGYVHATFY	AOC1	476	P19801
YHGHSRKKNVFMYGC	AGTPBP1	1016	Q9UPW5
MYTSYNKHISLHKAF	ATG2B	711	Q96BY7
TYYSSLGDYMKNIHK	AGAP6	291	Q5VW22
RGYAFVMYCHKHEAK	RBM47	111	A0AV96
YYFAAVAHLHMGKQA	PTPN23	246	Q9H3S7
QDHTFKSELGHYMYV	MAMDC2	206	Q7Z304
MGAEAHVNTCYKHFY	MOB3B	176	Q86TA1
FFYHMYGKHIGSLNL	MDGA1	836	Q8NFP4
LENMAYEHHYKGSSR	DDX3X	571	O00571
KYMSFTSGDKSAHGY	PAK3	151	O75914
MHASYLFQQDKHYDL	GAD2	421	Q05329
MDLFCYGSHYFHKVA	nan	296	A8MVJ9
QDFNKMKGAAHYHSL	NRAP	336	Q86VF7
YHKSEFYNKGMLSAH	KY	341	Q8NBH2
QMYYSGSLEAKSTHH	MFI	186	Q8NCR3
MSLNAYALDFYKHGS	DDX60	1636	Q8IY21
AQRGIGYHHSSMYFK	DDX60L	1241	Q5H9U9
GYHHSSMYFKEKEFV	DDX60L	1246	Q5H9U9
ILYMHFSHSYSGLAK	KIAA1586	501	Q9HCI6
HGHMGYVFSKTYNVT	PDE3A	796	Q14432
IYSFHGKVEKYMCFH	GPR55	156	Q9Y2T6
VQHDMKDGTAYYFHL	IQGAP3	671	Q86VI3
FHSMAYGHIGRKYQS	FBH1	511	Q8NFZ0
QMEDYHYAHLIKTFG	DOCK1	941	Q14185
DSMVHKHGLEFYGYI	PRMT3	76	O60678
FSSYGHYGIHEEMLK	PRMT3	221	O60678
YAVHGNMLHYVKDRF	COPA	326	P53621
HHMTKAFLFYGTDFN	FUT10	116	Q6P4F1
KMNYYDHADFHHSVK	C9orf43	376	Q8TAL5
SYKHKGALHNYKMTD	C5	1316	P01031
YMGLEFKKHHDYYIT	EFNB1	121	P98172
AEHYMFLKGHETYSY	DEGS1	231	O15121
AEHYMFLKGHETYSY	DEGS2	231	Q6QHC5
AHMKHSGYLYALGQK	CADPS2	486	Q86UW7
LLNNSHYYHMAHGKD	DLD	91	P09622
HYYHMAHGKDFASRG	DLD	96	P09622
MGAEAHVNTCYKHFY	MOB3C	176	Q70IA8
MHTYGIIYTGYATKH	FANK1	56	Q8TC84
NNHFSTMTKYKGQLY	MINDY2	446	Q8NBR6
SGDHSDHMHYYQGKK	RBM6	746	P78332
HYYHSEAFKGQMEKS	SPHKAP	321	Q2M3C7
DTSYGYKDFSRHGMH	SESN1	331	Q9Y6P5
YPTMKDFNHSYHACG	TMEM50A	46	O95807
QLHSYFYSTHDMKIG	TDRD6	971	O60522
FAHCASVYKHHYMDG	RHOT2	501	Q8IXI1
LNMNGYFHEAYFKKH	POMGNT1	506	Q8WZA1
DRHMYHSLYLKVKGN	RPL19	116	P84098
LDKMHYSIEGKDTHY	TENM2	2606	Q9NT68
HQSQDKKIHVYGYSM	PHPT1	81	Q9NRX4
SKYKLYRHMATHSAQ	PLAGL2	81	Q9UPG8
DMRHHGSFNYLKFFK	PVALEF	31	A0A1B0GWK0
AHAAFNKAASYFGMK	SGPL1	241	O95470
GMYYCKAQEHTFIHT	SEMA3D	661	O95025
NTYSYHLKFLLGHGM	ABCA8	131	O94911
KGSDSHIYNVHYTMS	CNMD	66	O75829
EHMYTHKGKSYRYNR	ZBTB25	366	P24278
IHVKQAGQHSYYSAM	SPATA4	281	Q8NEY3
FLDFNHFYGMQKYHH	PLCXD3	141	Q63HM9
YHKFMAFKSFADLQH	TNIK	1176	Q9UKE5
FMQYGDHLYSKGNHD	VPS11	391	Q9H270
FKMYGYLTQHQKIHT	ZNF573	591	Q86YE8
EYYAMLAKTGVHHYS	RPL30	61	P62888
SDKHGFTILNSMHKY	TBX2	216	Q13207
DHKYKMNLYGFHGGQ	TNXB	3121	P22105
YHYSKTQHSKAEHMQ	UBR1	836	Q8IWV7
KLYGYQAQHYVCMKH	TIMP4	186	Q99727
GQAGMHATYYHKASD	TOMM40	266	O96008
AHGHLAAVYMALGKY	TTC28	796	Q96AY4
HYNMFNHHFFDGKTA	ZCCHC4	241	Q9H5U6
MTYYILKNHQKSFHA	ZBTB38	526	Q8NAP3
QTVQKEYTYSKHGMH	ZNF891	261	A8MT65
DKQKLYYHATKAMTH	TBK1	586	Q9UHD2
GFIIHHYAGKVSYDM	MYO1E	501	Q12965
HSHLFMAYARVGEYK	NAA25	116	Q14CX7