Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncyclic nucleotide-dependent protein kinase activity

PRKACA PRKACB PRKACG PRKG2 PRKX PRKY

2.38e-1291136GO:0004690
GeneOntologyMolecularFunctioncAMP-dependent protein kinase activity

PRKACA PRKACB PRKACG PRKX PRKY

1.10e-1071135GO:0004691
GeneOntologyMolecularFunctionheparan sulfate 6-O-sulfotransferase activity

HS6ST2 HS6ST1 HS6ST3

1.76e-0731133GO:0017095
GeneOntologyMolecularFunctionAMP-activated protein kinase activity

PRKACA PRKACB PRKACG

2.06e-05101133GO:0004679
GeneOntologyMolecularFunctionprostaglandin-endoperoxide synthase activity

PTGS1 PTGS2

3.17e-0521132GO:0004666
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

PGA4 PGA5 CTSE PGA3

5.56e-05371134GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

PGA4 PGA5 CTSE PGA3

6.19e-05381134GO:0070001
GeneOntologyMolecularFunctionheparan sulfate sulfotransferase activity

HS6ST2 HS6ST1 HS6ST3

7.64e-05151133GO:0034483
GeneOntologyMolecularFunctionprotein kinase activity

PDK2 SPEG MST1 PRKACA PRKACB PRKACG FES IRAK3 PRKG2 PRKX PRKY

5.99e-0460011311GO:0004672
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

PDK2 SPEG PRKACA PRKACB PRKACG IRAK3 PRKG2 PRKX PRKY

9.82e-044461139GO:0004674
GeneOntologyBiologicalProcessprotein kinase A signaling

PRKACA PRKACB PRKACG PRKG2 PRKX PRKY

2.05e-07481106GO:0010737
GeneOntologyBiologicalProcessheparan sulfate proteoglycan biosynthetic process, enzymatic modification

HS6ST2 HS6ST1 HS6ST3

3.14e-05121103GO:0015015
GeneOntologyBiologicalProcessheparan sulfate proteoglycan biosynthetic process

HS6ST2 EXTL3 HS6ST1 HS6ST3

3.53e-05351104GO:0015012
GeneOntologyBiologicalProcesshigh-density lipoprotein particle assembly

PRKACA PRKACB PRKACG

4.06e-05131103GO:0034380
GeneOntologyBiologicalProcessregulation of postsynaptic neurotransmitter receptor activity

SHISA7 CHRNA5 NOTCH1

9.50e-05171103GO:0098962
GeneOntologyBiologicalProcessheparan sulfate proteoglycan metabolic process

HS6ST2 HS6ST1 HS6ST3

9.50e-05171103GO:0030201
GeneOntologyCellularComponentmultivesicular body lumen

PGA4 PGA5 PGA3

5.44e-0671143GO:0097486
GeneOntologyCellularComponentcAMP-dependent protein kinase complex

PRKACA PRKACB PRKACG

1.84e-05101143GO:0005952
GeneOntologyCellularComponentlate endosome lumen

PGA4 PGA5 PGA3

2.52e-05111143GO:0031906
GeneOntologyCellularComponentcholinergic synapse

CHRNA4 CHRNA5 SLC22A2

2.26e-04221143GO:0098981
DomainPeptidase_aspartic_dom

PGA4 PGA5 RTL1 CTSE PGA3

3.61e-08171095IPR021109
DomainAspartic_peptidase_N

PGA4 PGA5 CTSE PGA3

3.79e-0871094IPR012848
DomainA1_Propeptide

PGA4 PGA5 CTSE PGA3

3.79e-0871094PF07966
DomainIGc2

HSPG2 IGFN1 VSIG2 PSG4 SPEG SIGLEC5 NCAM2 HMCN2 SIGLEC10 NECTIN4 GPA33

1.29e-0723510911SM00408
DomainIg_sub2

HSPG2 IGFN1 VSIG2 PSG4 SPEG SIGLEC5 NCAM2 HMCN2 SIGLEC10 NECTIN4 GPA33

1.29e-0723510911IPR003598
DomainHeparan_SO4-6-sulfoTrfase

HS6ST2 HS6ST1 HS6ST3

1.93e-0731093IPR010635
DomainAspartic_peptidase_A1

PGA4 PGA5 CTSE PGA3

2.24e-07101094IPR001461
DomainPEPTIDASE_A1

PGA4 PGA5 CTSE PGA3

2.24e-07101094IPR033121
DomainAsp

PGA4 PGA5 CTSE PGA3

2.24e-07101094PF00026
DomainPEPTIDASE_A1

PGA4 PGA5 CTSE PGA3

2.24e-07101094PS51767
DomainIg_V-set

HSPG2 VSIG2 PSG4 SIGLEC5 NCAM2 PTGFRN BTN1A1 SIGLEC10 NECTIN4 GPA33

2.57e-0719910910IPR013106
Domain-

PGA4 PGA5 CTSE PGA3

5.24e-071210942.40.70.10
DomainASP_PROTEASE

PGA4 PGA5 CTSE PGA3

5.24e-07121094PS00141
DomainAspartic_peptidase_AS

PGA4 PGA5 CTSE PGA3

7.54e-07131094IPR001969
DomainIG

HSPG2 IGFN1 VSIG2 PSG4 SPEG SIGLEC5 NCAM2 PTGFRN HMCN2 BTN1A1 SIGLEC10 NECTIN4 GPA33

1.06e-0642110913SM00409
DomainIg_sub

HSPG2 IGFN1 VSIG2 PSG4 SPEG SIGLEC5 NCAM2 PTGFRN HMCN2 BTN1A1 SIGLEC10 NECTIN4 GPA33

1.06e-0642110913IPR003599
DomainV-set

HSPG2 VSIG2 PSG4 SIGLEC5 PTGFRN BTN1A1 SIGLEC10 NECTIN4 GPA33

1.31e-061841099PF07686
DomainIg-like_dom

HSPG2 IGFN1 VSIG2 PTCRA PSG4 SPEG SIGLEC5 NCAM2 PTGFRN HMCN2 BTN1A1 SIGLEC10 NECTIN4 GPA33

1.36e-0650310914IPR007110
DomainIGv

HSPG2 VSIG2 NCAM2 PTGFRN BTN1A1 GPA33

4.99e-06751096SM00406
DomainIG_LIKE

HSPG2 IGFN1 VSIG2 PSG4 SPEG SIGLEC5 NCAM2 PTGFRN HMCN2 BTN1A1 SIGLEC10 NECTIN4 GPA33

5.74e-0649110913PS50835
DomainIg-like_fold

HSPG2 IGFN1 VSIG2 PTCRA PSG4 SPEG SIGLEC5 NCAM2 PTGFRN HMCN2 BTN1A1 SIGLEC10 PKHD1 NECTIN4 GPA33

1.49e-0570610915IPR013783
Domainig

HSPG2 PSG4 SIGLEC5 NCAM2 PTGFRN SIGLEC10 NECTIN4 GPA33

1.57e-051901098PF00047
DomainImmunoglobulin

HSPG2 PSG4 SIGLEC5 NCAM2 PTGFRN SIGLEC10 NECTIN4 GPA33

1.57e-051901098IPR013151
DomainAGC-kinase_C

PRKACA PRKACB PRKACG PRKG2 PRKX

1.86e-05561095IPR000961
DomainAGC_KINASE_CTER

PRKACA PRKACB PRKACG PRKG2 PRKX

1.86e-05561095PS51285
DomainS_TK_X

PRKACA PRKACB PRKACG PRKG2 PRKX

1.86e-05561095SM00133
DomainEGF_LAM_2

HSPG2 LAMC3 NTN4 ATRNL1

2.68e-05301094PS50027
DomainEGF_LAM_1

HSPG2 LAMC3 NTN4 ATRNL1

2.68e-05301094PS01248
Domain-

HSPG2 IGFN1 VSIG2 PTCRA PSG4 SPEG SIGLEC5 NCAM2 PTGFRN BTN1A1 SIGLEC10 PKHD1 NECTIN4 GPA33

3.14e-05663109142.60.40.10
DomainProthrombin/thrombin

F2 MST1

3.37e-0521092IPR003966
DomainHGF-like

HGF MST1

3.37e-0521092IPR024174
DomainSulfotransfer_2

HS6ST2 HS6ST1 HS6ST3

4.09e-05121093PF03567
DomainSulfotransferase

HS6ST2 HS6ST1 HS6ST3

4.09e-05121093IPR005331
DomainEGF_Lam

HSPG2 LAMC3 NTN4 ATRNL1

5.00e-05351094SM00180
DomainLaminin_EGF

HSPG2 LAMC3 NTN4 ATRNL1

6.95e-05381094IPR002049
DomainEGF-like_dom

HSPG2 LAMC3 TECTA PTGS1 PTGS2 HMCN2 ATRNL1 NOTCH1

1.06e-042491098IPR000742
DomainKringle

HGF F2 MST1

1.24e-04171093IPR000001
DomainKringle_CS

HGF F2 MST1

1.24e-04171093IPR018056
DomainKRINGLE_2

HGF F2 MST1

1.24e-04171093PS50070
DomainKringle

HGF F2 MST1

1.24e-04171093PF00051
DomainKRINGLE_1

HGF F2 MST1

1.24e-04171093PS00021
DomainKR

HGF F2 MST1

1.24e-04171093SM00130
DomainEGF_1

HSPG2 LAMC3 PTGS1 PTGS2 NTN4 HMCN2 ATRNL1 NOTCH1

1.25e-042551098PS00022
DomainIg_I-set

HSPG2 IGFN1 VSIG2 SPEG NCAM2 HMCN2 SIGLEC10

1.25e-041901097IPR013098
DomainI-set

HSPG2 IGFN1 VSIG2 SPEG NCAM2 HMCN2 SIGLEC10

1.25e-041901097PF07679
DomainEGF-like_CS

HSPG2 LAMC3 PTGS1 PTGS2 NTN4 HMCN2 ATRNL1 NOTCH1

1.47e-042611098IPR013032
DomainHATPase_c

HSP90B1 PDK2 MLH3

1.48e-04181093SM00387
DomainHATPase_c

HSP90B1 PDK2 MLH3

1.75e-04191093PF02518
Domain-

RABEPK KLHL30 ATRNL1 KBTBD13

1.75e-044810942.120.10.80
Domain-

HSP90B1 PDK2 MLH3

2.05e-042010933.30.565.10
DomainHATPase_C

HSP90B1 PDK2 MLH3

2.38e-04211093IPR003594
DomainSushi

CSMD2 CSMD3 CFHR4 C2

2.40e-04521094PF00084
DomainCCP

CSMD2 CSMD3 CFHR4 C2

2.77e-04541094SM00032
DomainKelch-typ_b-propeller

RABEPK KLHL30 ATRNL1 KBTBD13

2.98e-04551094IPR015915
DomainSUSHI

CSMD2 CSMD3 CFHR4 C2

3.19e-04561094PS50923
DomainKinase-like_dom

SPEG ACAD10 PRKACA PRKACB PRKACG FES IRAK3 PRKG2 PRKX PRKY FOXF1

3.27e-0454210911IPR011009
DomainPAN_AP

HGF MST1

3.34e-0451092SM00473
DomainSushi_SCR_CCP_dom

CSMD2 CSMD3 CFHR4 C2

3.42e-04571094IPR000436
DomainEGF

HSPG2 LAMC3 TECTA PTGS1 PTGS2 ATRNL1 NOTCH1

4.58e-042351097SM00181
DomainCP2

TFCP2 TFCP2L1

4.99e-0461092PF04516
DomainCP2

TFCP2 TFCP2L1

4.99e-0461092IPR007604
DomainPAN

HGF MST1

6.95e-0471092PS50948
DomainPan_app

HGF MST1

6.95e-0471092IPR003609
DomainPAN_1

HGF MST1

6.95e-0471092PF00024
DomainKelch_1

RABEPK KLHL30 ATRNL1 KBTBD13

7.48e-04701094PF01344
DomainKelch_1

RABEPK KLHL30 ATRNL1 KBTBD13

7.48e-04701094IPR006652
DomainKringle-like

HGF F2 MST1

8.48e-04321093IPR013806
DomainEGF

HSPG2 TECTA PTGS1 PTGS2 NOTCH1

8.61e-041261095PF00008
DomainLAMININ_IVA

HSPG2 LAMC3

9.24e-0481092PS51115
DomainLaminin_B

HSPG2 LAMC3

9.24e-0481092PF00052
DomainLamB

HSPG2 LAMC3

9.24e-0481092SM00281
DomainLaminin_IV

HSPG2 LAMC3

9.24e-0481092IPR000034
DomainEGF_2

HSPG2 LAMC3 PTGS1 PTGS2 HMCN2 ATRNL1 NOTCH1

9.31e-042651097PS01186
DomainLaminin_EGF

HSPG2 LAMC3 NTN4

1.10e-03351093PF00053
DomainSer/Thr_kinase_AS

SPEG PRKACA PRKACB PRKACG IRAK3 PRKG2 PRKX PRKY

1.17e-033571098IPR008271
DomainPROTEIN_KINASE_ST

SPEG PRKACA PRKACB PRKACG IRAK3 PRKG2 PRKX PRKY

1.28e-033621098PS00108
DomainPROTEIN_KINASE_ATP

SPEG PRKACA PRKACB PRKACG FES IRAK3 PRKG2 PRKX PRKY

1.47e-034591099PS00107
DomainHaem_peroxidase

PTGS1 PTGS2

1.47e-03101092IPR010255
DomainAn_peroxidase

PTGS1 PTGS2

1.47e-03101092PF03098
DomainPEROXIDASE_3

PTGS1 PTGS2

1.47e-03101092PS50292
DomainHaem_peroxidase_animal

PTGS1 PTGS2

1.47e-03101092IPR019791
Domain-

PTGS1 PTGS2

1.47e-031010921.10.640.10
DomainC2-set_2

BTN1A1 SIGLEC10 NECTIN4

1.75e-03411093PF08205
DomainCD80_C2-set

BTN1A1 SIGLEC10 NECTIN4

1.75e-03411093IPR013162
DomainPkinase

SPEG PRKACA PRKACB PRKACG IRAK3 PRKG2 PRKX PRKY

1.77e-033811098PF00069
DomainCarbonic_anhydrase_a-class_CS

CA3 CA8

2.14e-03121092IPR018338
DomainGrowth_fac_rcpt_

HSPG2 LAMC3 NTN4 HMCN2 NOTCH1

2.22e-031561095IPR009030
DomainProt_kinase_dom

SPEG PRKACA PRKACB PRKACG FES IRAK3 PRKG2 PRKX PRKY

2.26e-034891099IPR000719
DomainPROTEIN_KINASE_DOM

SPEG PRKACA PRKACB PRKACG FES IRAK3 PRKG2 PRKX PRKY

2.39e-034931099PS50011
DomainKelch_2

RABEPK ATRNL1

2.52e-03131092IPR011498
DomainPMG

KRTAP13-2 KRTAP13-1

2.52e-03131092PF05287
DomainKRTAP_PMG

KRTAP13-2 KRTAP13-1

2.52e-03131092IPR007951
DomainKelch_2

RABEPK ATRNL1

2.52e-03131092PF07646
DomainEGF_3

HSPG2 PTGS1 PTGS2 HMCN2 ATRNL1 NOTCH1

2.57e-032351096PS50026
DomainCUB

CSMD2 CSMD3 ATRNL1

2.93e-03491093PF00431
DomainCUB

CSMD2 CSMD3 ATRNL1

3.10e-03501093SM00042
DomainCarbonic_anhydrase_a-class

CA3 CA8

3.37e-03151092IPR023561
DomainALPHA_CA_1

CA3 CA8

3.37e-03151092PS00162
Domain-

CSMD2 CSMD3 ATRNL1

3.47e-035210932.60.120.290
DomainCUB

CSMD2 CSMD3 ATRNL1

3.66e-03531093PS01180
PathwayKEGG_PRION_DISEASES

NCAM2 PRKACA PRKACB PRKACG PRKX NOTCH1

4.56e-0835826M13036
PathwayREACTOME_CREB1_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_ADENYLATE_CYCLASE

PRKACA PRKACB PRKACG PRKX

5.08e-0712824M27363
PathwayREACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_KEY_METABOLIC_FACTORS

PRKACA PRKACB PRKACG

1.88e-065823M26988
PathwayREACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB

PRKACA PRKACB PRKACG PRKX

4.80e-0620824M759
PathwayKEGG_MEDICUS_REFERENCE_PKA_HOLOENZYME

PRKACA PRKACB PRKACG

6.53e-067823M47896
PathwayREACTOME_HDL_ASSEMBLY

PRKACA PRKACB PRKACG

1.04e-058823M27840
PathwayKEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE

HS6ST2 EXTL3 HS6ST1 HS6ST3

1.44e-0526824M7330
PathwayREACTOME_ROBO_RECEPTORS_BIND_AKAP5

PRKACA PRKACB PRKACG

1.55e-059823M27877
PathwayKEGG_MEDICUS_REFERENCE_AVP_V2R_PKA_SIGNALING_PATHWAY

PRKACA PRKACB PRKACG

2.21e-0510823M47648
PathwayREACTOME_HS_GAG_BIOSYNTHESIS

HSPG2 HS6ST2 HS6ST1 HS6ST3

2.97e-0531824M685
PathwayWP_GASTRIC_ACID_PRODUCTION

PGA4 PGA5 PGA3

3.03e-0511823M39726
PathwayWP_CANCER_PATHWAYS

HGF HSP90B1 LAMC3 F2 PTGS2 MST1 BRCA2 PRKACA PRKACB PRKACG FZD10 NOTCH1

3.44e-055078212M48302
PathwayWP_CARDIOMYOCYTE_SIGNALING_CONVERGING_ON_TITIN

PRKACA PRKACB PRKACG PRKG2

3.83e-0533824M48071
PathwayREACTOME_REGULATION_OF_GLYCOLYSIS_BY_FRUCTOSE_2_6_BISPHOSPHATE_METABOLISM

PRKACA PRKACB PRKACG

4.02e-0512823M27950
PathwayWP_DOPAMINE_METABOLISM

PRKACA PRKACB PRKACG

5.20e-0513823M39622
PathwayREACTOME_CA_DEPENDENT_EVENTS

PRKACA PRKACB PRKACG PRKX

6.07e-0537824M749
PathwayREACTOME_TRIGLYCERIDE_METABOLISM

PRKACA PRKACB LPIN2 PRKACG

6.75e-0538824M27856
PathwayKEGG_MEDICUS_REFERENCE_EP_NE_ADRB_CAMP_SIGNALING_PATHWAY

PRKACA PRKACB PRKACG

8.21e-0515823M47794
PathwayKEGG_MEDICUS_REFERENCE_PTH_PTH1R_PKA_SIGNALING_PATHWAY

PRKACA PRKACB PRKACG

8.21e-0515823M47504
PathwayWP_GLYCOSAMINOGLYCAN_SYNTHESIS_IN_FIBROBLASTS

HS6ST2 EXTL3 HS6ST1 HS6ST3

9.14e-0541824M48095
PathwayREACTOME_DAG_AND_IP3_SIGNALING

PRKACA PRKACB PRKACG PRKX

9.14e-0541824M512
PathwayKEGG_MEDICUS_REFERENCE_DRD1_GNAS_AC_PKA_SIGNALING_PATHWAY

PRKACA PRKACB PRKACG

1.01e-0416823M47551
PathwayKEGG_MEDICUS_REFERENCE_LHCGR_GNAS_PKA_SIGNALING_PATHWAY

PRKACA PRKACB PRKACG

1.01e-0416823M47645
PathwayKEGG_MEDICUS_REFERENCE_FSHR_GNAS_PKA_SIGNALING_PATHWAY

PRKACA PRKACB PRKACG

1.01e-0416823M47650
PathwayREACTOME_RAP1_SIGNALLING

PRKACA PRKACB PRKACG

1.01e-0416823M923
PathwayREACTOME_ADORA2B_MEDIATED_ANTI_INFLAMMATORY_CYTOKINES_PRODUCTION

PRKACA PRKACB PRKACG PRKX

1.10e-0443824M29837
PathwayKEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION

PRKACA PRKACB PRKACG PRKX

1.21e-0444824M9011
PathwayREACTOME_PKA_ACTIVATION_IN_GLUCAGON_SIGNALLING

PRKACA PRKACB PRKACG

1.22e-0417823M26995
PathwayKEGG_MEDICUS_REFERENCE_CX3CR1_GNAI_AC_PKA_SIGNALING_PATHWAY

PRKACA PRKACB PRKACG

1.22e-0417823M47544
PathwayKEGG_APOPTOSIS

PRKACA PRKACB PRKACG IRAK3 PRKX

1.50e-0487825M8492
PathwayREACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY

PRKACA PRKACB PRKACG

1.72e-0419823M27841
PathwayKEGG_GAP_JUNCTION

PRKACA PRKACB PRKACG PRKG2 PRKX

1.76e-0490825M4013
PathwayKEGG_TASTE_TRANSDUCTION

PRKACA PRKACB PRKACG PRKX

2.33e-0452824M5785
PathwayWP_NICOTINE_EFFECT_ON_DOPAMINERGIC_NEURONS

CHRNA4 CHRNA5 PRKACA

2.34e-0421823M39343
PathwayREACTOME_CD209_DC_SIGN_SIGNALING

PRKACA PRKACB PRKACG

2.34e-0421823M27485
PathwayREACTOME_G_PROTEIN_MEDIATED_EVENTS

PRKACA PRKACB PRKACG PRKX

2.70e-0454824M26911
PathwayKEGG_VIBRIO_CHOLERAE_INFECTION

PRKACA PRKACB PRKACG PRKX

2.70e-0454824M17906
PathwayKEGG_MELANOGENESIS

PRKACA PRKACB PRKACG FZD10 PRKX

3.01e-04101825M7761
PathwayKEGG_HEDGEHOG_SIGNALING_PATHWAY

PRKACA PRKACB PRKACG PRKX

3.10e-0456824M1053
PathwayBIOCARTA_ACETAMINOPHEN_PATHWAY

PTGS1 PTGS2

3.30e-045822M22024
PathwayREACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM

HSPG2 HS6ST2 HS6ST1 HS6ST3

3.32e-0457824M692
PathwayREACTOME_TRIGLYCERIDE_CATABOLISM

PRKACA PRKACB PRKACG

3.52e-0424823M10064
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_GNAS_TO_CRHR_PKA_ACTH_SIGNALING_PATHWAY

PRKACA PRKACB PRKACG

3.52e-0424823M47520
PathwayREACTOME_DARPP_32_EVENTS

PRKACA PRKACB PRKACG

3.52e-0424823M751
PathwayREACTOME_DEGRADATION_OF_GLI1_BY_THE_PROTEASOME

PSME4 PRKACA PRKACB PRKACG

4.05e-0460824M27470
PathwayKEGG_MEDICUS_PATHOGEN_HCMV_UL33_TO_GNAI_AC_PKA_SIGNALING_PATHWAY

PRKACA PRKACB PRKACG

4.48e-0426823M47553
PathwayPID_IL3_PATHWAY

PRKACA PRKACB PRKACG

4.48e-0426823M182
PathwayREACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION

PRKACA PRKACB

4.94e-046822MM14628
PathwayKEGG_MEDICUS_REFERENCE_CRHR_PKA_ACTH_SIGNALING_PATHWAY

PRKACA PRKACB PRKACG

5.02e-0427823M47518
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_RASD1_TO_CRHR_PKA_ACTH_SIGNALING_PATHWAY

PRKACA PRKACB PRKACG

5.02e-0427823M47519
PathwayKEGG_OOCYTE_MEIOSIS

PRKACA PRKACB PRKACG PRKX STAG3

5.06e-04113825M16817
PathwayKEGG_MEDICUS_REFERENCE_GHRHR_PKA_GH_SIGNALING_PATHWAY

PRKACA PRKACB PRKACG

5.60e-0428823M47647
PathwayREACTOME_HS_GAG_BIOSYNTHESIS

HS6ST2 HS6ST1 HS6ST3

6.21e-0429823MM14802
PathwayWP_LIPID_METABOLISM_PATHWAY

PRKACA PRKACB PRKACG

6.21e-0429823M39762
PathwayKEGG_MEDICUS_REFERENCE_TSH_TG_SIGNALING_PATHWAY

PRKACA PRKACB PRKACG

6.21e-0429823M47627
PathwayWP_CANNABINOID_RECEPTOR_SIGNALING

PRKACA PRKACB PRKACG

6.21e-0429823M39676
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_GNAS_TO_ACTH_CORTISOL_SIGNALING_PATHWAY

PRKACA PRKACB PRKACG

6.21e-0429823M47515
PathwayREACTOME_SURFACTANT_METABOLISM

PGA4 PGA5 PGA3

6.88e-0430823M27566
PathwayWP_GPR143_IN_MELANOCYTES_AND_RETINAL_PIGMENT_EPITHELIUM_CELLS

PRKACA PRKACB PRKACG

6.88e-0430823M42578
PathwayREACTOME_HDL_ASSEMBLY

PRKACA PRKACB

6.89e-047822MM15560
PathwayKEGG_LONG_TERM_POTENTIATION

PRKACA PRKACB PRKACG PRKX

7.28e-0470824M3115
PathwayKEGG_MEDICUS_VARIANT_CYP11B1_CYP11B2_FUSION_TO_ACTH_CORTISOL_SIGNALING_PATHWAY

PRKACA PRKACB PRKACG

7.58e-0431823M47507
PathwayKEGG_MEDICUS_REFERENCE_ACTH_CORTISOL_SIGNALING_PATHWAY

PRKACA PRKACB PRKACG

8.33e-0432823M47506
PathwayREACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION

PRKACA PRKACB PRKACG

9.13e-0433823M11575
PathwayBIOCARTA_ACETAMINOPHEN_PATHWAY

PTGS1 PTGS2

9.15e-048822MM1547
PathwayREACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES

CHRNA4 CHRNA5 SLC22A2 PRKACA PRKACB PRKACG PRKX

9.78e-04270827M15514
PathwayKEGG_MEDICUS_REFERENCE_ADRB3_UCP1_SIGNALING_PATHWAY

PRKACA PRKACB PRKACG

1.09e-0335823M47969
PathwayREACTOME_HIGHLY_CALCIUM_PERMEABLE_NICOTINIC_ACETYLCHOLINE_RECEPTORS

CHRNA4 CHRNA5

1.17e-039822M27597
PathwayREACTOME_HIGHLY_CALCIUM_PERMEABLE_NICOTINIC_ACETYLCHOLINE_RECEPTORS

CHRNA4 CHRNA5

1.17e-039822MM15313
PathwayWP_ACETAMINOPHEN_IN_ANALGESIA_AND_ANTIPYRESIS

PTGS1 PTGS2

1.17e-039822M48307
PathwayPID_GMCSF_PATHWAY

PRKACA PRKACB PRKACG

1.18e-0336823M22
PathwayREACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION

CHRNA4 CHRNA5 PRKACA PRKACB PRKACG PRKX

1.23e-03205826M752
PathwayREACTOME_METABOLISM_OF_CARBOHYDRATES

HSPG2 HS6ST2 HS6ST1 PRKACA PRKACB PRKACG HS6ST3

1.42e-03288827M16864
PathwayREACTOME_MET_ACTIVATES_RAS_SIGNALING

HGF RANBP10

1.46e-0310822MM15488
PathwayKEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION

PRKACA PRKACB PRKACG PRKX

1.51e-0385824M3578
PathwayREACTOME_RET_SIGNALING

PRKACA PRKACB PRKACG

1.60e-0340823M27746
PathwayWP_COMMON_PATHWAYS_UNDERLYING_DRUG_ADDICTION

PRKACA PRKACB PRKACG

1.72e-0341823M39655
PathwayBIOCARTA_AKAP95_PATHWAY

PRKACB PRKACG

1.78e-0311822M5731
PathwayREACTOME_MET_ACTIVATES_RAS_SIGNALING

HGF RANBP10

1.78e-0311822M27740
PathwayBIOCARTA_PLCE_PATHWAY

PRKACB PRKACG

1.78e-0311822M5576
PathwayREACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS

CHRNA4 CHRNA5

1.78e-0311822M883
PathwayBIOCARTA_CFTR_PATHWAY

PRKACB PRKACG

1.78e-0311822M12399
PathwayBIOCARTA_AGPCR_PATHWAY

PRKACB PRKACG

1.78e-0311822M19829
PathwayBIOCARTA_AKAP13_PATHWAY

PRKACB PRKACG

1.78e-0311822M17668
PathwayKEGG_MEDICUS_REFERENCE_HEPARAN_SULFATE_BIOSYNTHESIS

EXTL3 HS6ST1

1.78e-0311822M47921
PathwayREACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION

PRKACA PRKACB PRKACG

1.85e-0342823M791
PathwayKEGG_WNT_SIGNALING_PATHWAY

PRKACA PRKACB PRKACG FZD10 PRKX

1.86e-03151825M19428
PathwayREACTOME_OPIOID_SIGNALLING

PRKACA PRKACB PRKACG PRKX

1.86e-0390824M6467
PathwayKEGG_DILATED_CARDIOMYOPATHY

PRKACA PRKACB PRKACG PRKX

1.86e-0390824M835
PathwayWP_HEDGEHOG_SIGNALING_WP4249

PRKACA PRKACB PRKACG

1.98e-0343823M39706
PathwayREACTOME_VASOPRESSIN_REGULATES_RENAL_WATER_HOMEOSTASIS_VIA_AQUAPORINS

PRKACA PRKACB PRKACG

1.98e-0343823M933
PathwayREACTOME_MAPK6_MAPK4_SIGNALING

PSME4 PRKACA PRKACB PRKACG

2.10e-0393824M27572
PathwayWP_VASOPRESSINREGULATED_WATER_REABSORPTION

PRKACA PRKACB PRKACG

2.12e-0344823M42554
PathwayBIOCARTA_CARM1_PATHWAY

PRKACB PRKACG

2.12e-0312822M7968
PathwayREACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS

CHRNA4 CHRNA5

2.12e-0312822M48008
PathwayREACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS

CHRNA4 CHRNA5

2.12e-0312822MM15312
PathwayREACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS

PRKACA PRKACB PRKACG PRKX

2.18e-0394824M2843
PathwayWP_PROSTAGLANDIN_SYNTHESIS_AND_REGULATION

PTGFRN PTGS1 PTGS2

2.26e-0345823M39355
PathwayREACTOME_GPER1_SIGNALING

PRKACA PRKACB PRKACG

2.26e-0345823M45008
PathwayREACTOME_FCGR3A_MEDIATED_IL10_SYNTHESIS

PRKACA PRKACB PRKACG PRKX

2.27e-0395824M29842
Pubmed

Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase.

PRKACA PRKACB PRKACG

3.52e-08311532342480
Pubmed

The epidemiology of low serum pepsinogen A levels and an international association with gastric cancer rates. EUROGAST Study Group.

PGA4 PGA5 PGA3

3.52e-08311537926498
Pubmed

Crystal structure of human pepsinogen A.

PGA4 PGA5 PGA3

3.52e-08311539561228
Pubmed

The combination of serum trefoil factor 3 and pepsinogen testing is a valid non-endoscopic biomarker for predicting the presence of gastric cancer: a new marker for gastric cancer risk.

PGA4 PGA5 PGA3

3.52e-083115321455714
Pubmed

Serum pepsinogen level, atrophic gastritis and the risk of incident pancreatic cancer--a prospective cohort study.

PGA4 PGA5 PGA3

3.52e-083115319800305
Pubmed

Serum pepsinogen reference intervals in apparently healthy Chinese population with latex enhanced turbidimetric immunoassay.

PGA4 PGA5 PGA3

3.52e-083115324170207
Pubmed

Relationships between the human pepsinogen DNA and protein polymorphisms.

PGA4 PGA5 PGA3

3.52e-08311533014868
Pubmed

The ratio of pepsinogen A to pepsinogen C: a sensitive test for atrophic gastritis.

PGA4 PGA5 PGA3

3.52e-08311532799289
Pubmed

CRYSTALLINE PEPSIN : I. ISOLATION AND TESTS OF PURITY.

PGA4 PGA5 PGA3

3.52e-083115319872561
Pubmed

Human pepsinogen A (PGA): an informative gene complex located at 11q13.

PGA4 PGA5 PGA3

3.52e-08311531968039
Pubmed

The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine.

HS6ST2 HS6ST1 HS6ST3

3.52e-083115310644753
Pubmed

Helicobacter pylori infection and serum pepsinogen A, pepsinogen C, and gastrin in gastritis and peptic ulcer: significance of inflammation and effect of bacterial eradication.

PGA4 PGA5 PGA3

3.52e-08311538053437
Pubmed

Family and population studies on the human pepsinogen A multigene family.

PGA4 PGA5 PGA3

3.52e-08311532566575
Pubmed

Immunoblot technique to visualise serum pepsinogen A isozymogen patterns.

PGA4 PGA5 PGA3

3.52e-08311532229438
Pubmed

Prediction of gastric cancer development by serum pepsinogen test and Helicobacter pylori seropositivity in Eastern Asians: a systematic review and meta-analysis.

PGA4 PGA5 PGA3

3.52e-083115325314140
Pubmed

Validation of the pepsinogen test method for gastric cancer screening using a follow-up study.

PGA4 PGA5 PGA3

3.52e-083115319890696
Pubmed

Diagnostic value of serum pepsinogen C in patients with raised serum concentrations of pepsinogen A.

PGA4 PGA5 PGA3

3.52e-08311538244094
Pubmed

Plasma pepsinogens, antibodies against Helicobacter pylori, and risk of gastric cancer in the Shanghai Women's Health Study Cohort.

PGA4 PGA5 PGA3

3.52e-083115321407214
Pubmed

Isolation of an activation intermediate and determination of the amino acid sequence of the activation segment of human pepsinogen A.

PGA4 PGA5 PGA3

3.52e-08311536774973
Pubmed

Primary structure of human pepsinogen gene.

PGA4 PGA5 PGA3

3.52e-08311536300126
Pubmed

Pepsinogen I/II ratio is related to glucose, triacylglycerol, and uric acid levels.

PGA4 PGA5 PGA3

3.52e-083115322304859
Pubmed

Pepsinogen I and II expressions in situ and their correlations with serum pesignogen levels in gastric cancer and its precancerous disease.

PGA4 PGA5 PGA3

3.52e-083115324004680
Pubmed

Effect of enprostil on serum gastrin and pepsinogen A and C levels in patients on long-term treatment with omeprazole.

PGA4 PGA5 PGA3

3.52e-08311538038355
Pubmed

The paradoxical increase in cortisol secretion induced by dexamethasone in primary pigmented nodular adrenocortical disease involves a glucocorticoid receptor-mediated effect of dexamethasone on protein kinase A catalytic subunits.

PRKACA PRKACB PRKACG

3.52e-083115319383776
Pubmed

Human pepsinogen A isozymogen patterns in serum and gastric mucosa.

PGA4 PGA5 PGA3

3.52e-08311532227273
Pubmed

Identification of a high risk gastric cancer group using serum pepsinogen after successful eradication of Helicobacter pylori.

PGA4 PGA5 PGA3

3.52e-083115323034090
Pubmed

A possible association of low pepsinogen I and pepsinogen I/II with low and high body weight in Japanese men.

PGA4 PGA5 PGA3

3.52e-083115324125879
Pubmed

Effects of omeprazole and lansoprazole on fasting and postprandial serum gastrin and serum pepsinogen A and C.

PGA4 PGA5 PGA3

3.52e-08311538751234
Pubmed

Enzyme-linked immunosorbent assay and radioimmunoassay of serum pepsinogen A.

PGA4 PGA5 PGA3

3.52e-08311533554488
Pubmed

Expression of serum miR-20a-5p, let-7a, and miR-320a and their correlations with pepsinogen in atrophic gastritis and gastric cancer: a case-control study.

PGA4 PGA5 PGA3

3.52e-083115323521833
Pubmed

Close linkage of human chromosomal pepsinogen A genes.

PGA4 PGA5 PGA3

3.52e-08311533017318
Pubmed

Serum pepsinogen test for early detection of gastric cancer in a European country.

PGA4 PGA5 PGA3

3.52e-083115321989121
Pubmed

Serum antibodies to H+,K+-ATPase, serum pepsinogen A and Helicobacter pylori in relation to gastric mucosa morphology in patients with low or low-normal concentrations of serum cobalamins.

PGA4 PGA5 PGA3

3.52e-08311539855083
Pubmed

Advantages of serum pepsinogen A combined with gastrin or pepsinogen C as first-line analytes in the evaluation of suspected cobalamin deficiency: a study in patients previously not subjected to gastrointestinal surgery.

PGA4 PGA5 PGA3

3.52e-08311539797498
Pubmed

The glomerular sieving of pepsinogen A and C in man.

PGA4 PGA5 PGA3

3.52e-08311532478370
Pubmed

Clinical significance of pepsinogen A isozymogens, serum pepsinogen A and C levels, and serum gastrin levels.

PGA4 PGA5 PGA3

3.52e-08311533815274
Pubmed

Pepsinogens: physiology, pharmacology pathophysiology and exercise.

PGA4 PGA5 PGA3

3.52e-083115310675278
Pubmed

Pepsinogen A polymorphism in gastric mucosa and urine, with special reference to patients with gastric cancer.

PGA4 PGA5 PGA3

3.52e-08311533780036
Pubmed

Identification of a Glu greater than Lys substitution in the activation segment of human pepsinogen A-3 and -5 isozymogens by peptide mapping using endoproteinase Lys-C.

PGA4 PGA5 PGA3

3.52e-08311532901984
Pubmed

Assignment of human pepsinogen A locus to the q12-pter region of chromosome 11.

PGA4 PGA5 PGA3

3.52e-08311533839486
Pubmed

Active cAMP-dependent protein kinase incorporated within highly purified HIV-1 particles is required for viral infectivity and interacts with viral capsid protein.

PRKACA PRKACB PRKACG

3.52e-083115312842892
Pubmed

Differential expression of heparan sulfate 6-O-sulfotransferase isoforms in the mouse embryo suggests distinctive roles during organogenesis.

HS6ST2 HS6ST1 HS6ST3

3.52e-083115315499561
Pubmed

Assignment of the pepsinogen gene complex (PGA) to human chromosome region 11q13 by in situ hybridization.

PGA4 PGA5 PGA3

3.52e-08311533467902
Pubmed

The pepsinogens of human gastric mucosa.

PGA4 PGA5 PGA3

3.52e-08311534586732
Pubmed

Substrate specificities of mouse heparan sulphate glucosaminyl 6-O-sulphotransferases.

HS6ST2 HS6ST1 HS6ST3

3.52e-083115312611590
Pubmed

Genomic structure and evolution of the human pepsinogen A multigene family.

PGA4 PGA5 PGA3

3.52e-08311532892778
Pubmed

The value of serum pepsinogen levels for the diagnosis of gastric diseases in Chinese Han people in midsouth China.

PGA4 PGA5 PGA3

3.52e-083115324383519
Pubmed

Gene structures of pepsinogens A and C.

PGA4 PGA5 PGA3

3.52e-08311531455184
Pubmed

Hypomethylation and expression of pepsinogen A genes in the fundic mucosa of human stomach.

PGA4 PGA5 PGA3

3.52e-08311532831884
Pubmed

Localization of pepsinogen (A and C) and cellular differentiation of pepsinogen-synthesizing cells in the human gastric mucosa.

PGA4 PGA5 PGA3

3.52e-08311532032552
Pubmed

Analysis of the promoter of a human pepsinogen A gene.

PGA4 PGA5 PGA3

3.52e-08311531812762
Pubmed

O6-methylguanine in blood leucocyte DNA: an association with the geographic prevalence of gastric cancer and with low levels of serum pepsinogen A, a marker of severe chronic atrophic gastritis. The EUROGAST Study Group.

PGA4 PGA5 PGA3

3.52e-08311537923573
Pubmed

Fast detection of phosphorylation of human pepsinogen A, human pepsinogen C and swine pepsinogen using a combination of reversed-phase high-performance liquid chromatography and capillary zone electrophoresis for peptide mapping.

PGA4 PGA5 PGA3

3.52e-08311539061458
Pubmed

Ratio between serum IL-8 and pepsinogen A/C: a marker for atrophic body gastritis.

PGA4 PGA5 PGA3

3.52e-083115312588289
Pubmed

Gastric cancer detection using gastric juice pepsinogen and melanoma-associated gene RNA.

PGA4 PGA5 PGA3

3.52e-083115323897256
Pubmed

An aspartic proteinase expressed in the yolk sac and neonatal stomach of the mouse.

PGA4 PGA5 PGA3

3.52e-083115311566730
Pubmed

The effect of acute and chronic protein loading on urinary pepsinogen A excretion.

PGA4 PGA5 PGA3

3.52e-08311531956484
Pubmed

Transcription regulation of human and porcine pepsinogen A.

PGA4 PGA5 PGA3

3.52e-08311538540382
Pubmed

Exploratory findings of audiometry in adult patients with otitis media with high pepsinogen concentrations: a preliminary study.

PGA4 PGA5 PGA3

3.52e-083115322992016
Pubmed

The role of serum pepsinogen in the detection of gastric cancer.

PGA4 PGA5 PGA3

3.52e-083115320981206
Pubmed

Gastric chief cell-specific transcription of the pepsinogen A gene.

PGA4 PGA5 PGA3

3.52e-08311538504820
Pubmed

Detection of pepsinogen in the neonatal lung and stomach by immunohistochemistry.

PGA4 PGA5 PGA3

3.52e-083115321970995
Pubmed

Heparan sulfate 6-O-sulfotransferase isoform-dependent regulatory effects of heparin on the activities of various proteases in mast cells and the biosynthesis of 6-O-sulfated heparin.

HS6ST2 HS6ST1 HS6ST3

3.52e-083115323223449
Pubmed

Serum pepsinogens in gastric cancer screening.

PGA4 PGA5 PGA3

3.52e-083115320428942
Pubmed

The relationship of Helicobacter pylori colonization, the serum pepsinogen A level, and gastric resection.

PGA4 PGA5 PGA3

3.52e-08311539525001
Pubmed

Evaluation of pepsinogen A and gastrin-17 as markers of gastric cancer and high-risk pathologic conditions.

PGA4 PGA5 PGA3

3.52e-08311537886402
Pubmed

Serum pepsinogen and gastric cancer screening.

PGA4 PGA5 PGA3

3.52e-083115317379991
Pubmed

Low serum pepsinogen I and pepsinogen I/II ratio and Helicobacter pylori infection are associated with increased risk of gastric cancer: 14-year follow up result in a rural Chinese community.

PGA4 PGA5 PGA3

3.52e-083115321547904
Pubmed

Overexpression of heparan sulfate 6-O-sulfotransferases in human embryonic kidney 293 cells results in increased N-acetylglucosaminyl 6-O-sulfation.

HS6ST2 HS6ST1 HS6ST3

3.52e-083115316326709
Pubmed

Stem domains of heparan sulfate 6-O-sulfotransferase are required for Golgi localization, oligomer formation and enzyme activity.

HS6ST2 HS6ST1 HS6ST3

1.41e-074115315226404
Pubmed

Proteoglycans and their roles in brain cancer.

HSPG2 HS6ST2 HS6ST1

1.41e-074115323281850
Pubmed

Serum pepsinogen I/II ratio is correlated with albuminuria in patients with type 2 diabetes.

PGA4 PGA5 PGA3

1.41e-074115323047493
Pubmed

Pepsinogens, progastricsins, and prochymosins: structure, function, evolution, and development.

PGA4 PGA5 PGA3

1.41e-074115311915945
Pubmed

Protein kinase A-induced phosphorylation of the p65 subunit of nuclear factor-kappaB promotes Schwann cell differentiation into a myelinating phenotype.

PRKACA PRKACB PRKACG

1.41e-074115318385332
Pubmed

Analysis of axon guidance defects at the optic chiasm in heparan sulphate sulphotransferase compound mutant mice.

HS6ST2 HS6ST1 HS6ST3

1.41e-074115321951307
Pubmed

Pepsinogen A and C serum levels in relation to acute NSAID-associated mucosal lesions in healthy volunteers.

PGA4 PGA5 PGA3

1.41e-07411538322031
Pubmed

Transcription factor SOX2 up-regulates stomach-specific pepsinogen A gene expression.

PGA4 PGA5 PGA3

1.41e-074115317136346
Pubmed

Pepsinogen A, pepsinogen C, and gastrin as markers of atrophic chronic gastritis in European dyspeptics.

PGA4 PGA5 PGA3

1.41e-074115312698190
Pubmed

Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all.

PRKACA PRKACB PRKACG APOBEC3C

2.61e-0717115424189052
Pubmed

HIV-1 Tat binds to SH3 domains: cellular and viral outcome of Tat/Grb2 interaction.

PRKACA PRKACB PRKACG

3.50e-075115321745501
Pubmed

HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling.

PRKACA PRKACB PRKACG

3.50e-075115312972513
Pubmed

Overexpressing PKIB in prostate cancer promotes its aggressiveness by linking between PKA and Akt pathways.

PRKACA PRKACB PRKACG

3.50e-075115319483721
Pubmed

Accuracy and cut-off values of pepsinogens I, II and gastrin 17 for diagnosis of gastric fundic atrophy: influence of gastritis.

PGA4 PGA5 PGA3

3.50e-075115322066020
Pubmed

Effects of [D-Ala1] peptide T-NH2 and HIV envelope glycoprotein gp120 on cyclic AMP dependent protein kinases in normal and psoriatic human fibroblasts.

PRKACA PRKACB PRKACG

3.50e-07511539540970
Pubmed

PKA-mediated stabilization of FoxH1 negatively regulates ERalpha activity.

PRKACA PRKACB PRKACG

3.50e-075115319711044
Pubmed

Architectural DNA-binding properties of the spermatidal transition proteins 1 and 2.

PRKACA PRKACB PRKACG

6.99e-07611539837753
Pubmed

Ser276 phosphorylation of NF-kB p65 by MSK1 controls SCF expression in inflammation.

PRKACA PRKACB PRKACG

6.99e-076115319197368
Pubmed

Sulfatase 1 is an inhibitor of ductal morphogenesis with sexually dimorphic expression in the urogenital sinus.

HS6ST2 HS6ST1 HS6ST3

1.22e-067115320410206
Pubmed

Dynamic binding of PKA regulatory subunit RI alpha.

PRKACA PRKACB PRKACG

1.22e-067115316407073
Pubmed

Phosphorylation of HIV Nef by cAMP-dependent protein kinase.

PRKACA PRKACB PRKACG

1.22e-067115315629779
Pubmed

CCL3L1 prevents gp120-induced neuron death via the CREB cell signaling pathway.

PRKACA PRKACB PRKACG

1.95e-068115319100722
Pubmed

Mice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethality.

HS6ST2 HS6ST1 HS6ST3

1.95e-068115317405882
Pubmed

Bicc1 links the regulation of cAMP signaling in polycystic kidneys to microRNA-induced gene silencing.

PRKACA PRKX PRKY

1.95e-068115322641646
Pubmed

Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1).

PRKACA PRKACB PRKACG

1.95e-068115312628924
Pubmed

Lacrimal gland development and Fgf10-Fgfr2b signaling are controlled by 2-O- and 6-O-sulfated heparan sulfate.

HS6ST2 HS6ST1 HS6ST3

2.92e-069115321357686
Pubmed

Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes.

PRKACA PRKACB PRKACG

2.92e-06911537688126
Pubmed

HIV-1 Tat-peptide inhibits protein kinase C and protein kinase A through substrate competition.

PRKACA PRKACB PRKACG

4.16e-0610115320433920
Pubmed

Involvement of heparan sulfate 6-O-sulfation in the regulation of energy metabolism and the alteration of thyroid hormone levels in male mice.

HS6ST2 HS6ST1 HS6ST3

5.70e-0611115323690091
Pubmed

Developmental and regional expression of heparan sulfate sulfotransferase genes in the mouse brain.

HS6ST2 HS6ST1 HS6ST3

5.70e-0611115315944372
Pubmed

PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.

PRKACA PRKACB PRKACG

7.58e-0612115310830164
GeneFamilyAdenosine receptors|V-set domain containing

VSIG2 PSG4 SIGLEC5 PTGFRN BTN1A1 SIGLEC10 NECTIN4 GPA33

4.12e-07163768590
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

HSPG2 IGFN1 VSIG2 SPEG NCAM2 HMCN2

5.94e-05161766593
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

CSMD2 CSMD3 CFHR4 C2

9.62e-05577641179
GeneFamilySulfotransferases, membrane bound

HS6ST2 HS6ST1 HS6ST3

5.00e-0437763763
GeneFamilyC2-set domain containing|Immunoglobulin like domain containing|Scavenger receptors

BTN1A1 SIGLEC10 NECTIN4

6.31e-0440763592
GeneFamilyCholinergic receptors nicotinic subunits

CHRNA4 CHRNA5

2.01e-0316762173
GeneFamilyCarbonic anhydrases

CA3 CA8

2.55e-0318762460
CoexpressionAtlasDevelopingLowerUrinaryTract_P1_ureter_emap-30363_k-means-cluster#1_top-relative-expression-ranked_200

TC2N PKHD1 CTSE CA3

1.13e-05271114gudmap_developingLowerUrinaryTract_P1_ureter_200_k1
CoexpressionAtlasDevelopingLowerUrinaryTract_P1_ureter_emap-30363_top-relative-expression-ranked_1000

VSIG2 PTGS1 CLDN11 TC2N KLHL30 EHF PKHD1 NECTIN4 IRAK3 C2 PRKG2 CTSE FOXF1 CA3 CA8

1.22e-0577411115gudmap_developingLowerUrinaryTract_P1_ureter_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_P1_ureter_emap-30363_k-means-cluster#1_top-relative-expression-ranked_1000

PTGS1 KLHL30 IRAK3 C2 CTSE CA3

4.20e-051211116gudmap_developingLowerUrinaryTract_P1_ureter_1000_k1
CoexpressionAtlasDevelopingLowerUrinaryTract_adult_bladder_emap-29457_top-relative-expression-ranked_100

TC2N EHF PKHD1 CTSE CA3

5.91e-05791115gudmap_developingLowerUrinaryTract_adult_bladder_100
CoexpressionAtlasDevelopingKidney_e15.5_Medullary collecting duct_emap-28063_top-relative-expression-ranked_100

PTGS1 TFCP2L1 EHF PKHD1 CTSE

5.91e-05791115DevelopingKidney_e15.5_Medullary collecting duct_emap-28063_100
CoexpressionAtlasDevelopingLowerUrinaryTract_e15.5_Urothelium_emap-28091_k-means-cluster#4_top-relative-expression-ranked_100

PKHD1 CTSE CA3

7.41e-05161113gudmap_developingLowerUrinaryTract_e15.5_Urothelium_100_k4
CoexpressionAtlasDevelopingLowerUrinaryTract_P1_ureter_emap-30363_k-means-cluster#4_top-relative-expression-ranked_500

PTGS1 C2 CTSE CA3

1.06e-04471114gudmap_developingLowerUrinaryTract_P1_ureter_500_k4
CoexpressionAtlasDevelopingLowerUrinaryTract_adult_bladder_emap-29457_top-relative-expression-ranked_1000

VSIG2 MFSD6 PTGS1 NTN4 TC2N KLHL30 EHF PKHD1 NECTIN4 C2 CTSE FOXF1 CA3

1.20e-0473411113gudmap_developingLowerUrinaryTract_adult_bladder_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_adult_ureter_emap-29479_top-relative-expression-ranked_500

MFSD6 NTN4 TFCP2L1 TC2N EHF PKHD1 NECTIN4 CTSE CA8

1.51e-043731119gudmap_developingLowerUrinaryTract_adult_ureter_500
CoexpressionAtlasDevelopingLowerUrinaryTract_adult_bladder_emap-29457_top-relative-expression-ranked_500

VSIG2 MFSD6 PTGS1 TC2N KLHL30 EHF PKHD1 CTSE CA3

1.67e-043781119gudmap_developingLowerUrinaryTract_adult_bladder_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_k-means-cluster#4_top-relative-expression-ranked_100

PCDHA11 CLDN11 FOXF1

1.99e-04221113gudmap_developingLowerUrinaryTract_e14.5_ urethra_100_k4
CoexpressionAtlasDevelopingLowerUrinaryTract_P1_ureter_emap-30363_top-relative-expression-ranked_500

PTGS1 TC2N EHF PKHD1 NECTIN4 C2 CTSE CA3 CA8

2.11e-043901119gudmap_developingLowerUrinaryTract_P1_ureter_500
ToppCellfacs-Lung-EPCAM-24m-Epithelial-Alveolar_Epithelial_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VSIG2 TFCP2L1 EHF PKHD1 GPA33 SLC25A48 CA8

5.54e-0718611573c4994a1a7db06a61da8170e45e06aaef7896592
ToppCell(5)_Epithelial_cells-(5)_Glands_duct|(5)_Epithelial_cells / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

ANKRD66 TFCP2L1 CLDN11 FES IRAK3 C2 CA8

5.54e-071861157219b1aeca17503244fabbb780bca58f22c7c0f27
ToppCellfacs-Lung-EPCAM-24m-Epithelial-type_II_pneumocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VSIG2 TFCP2L1 EHF PKHD1 GPA33 SLC25A48 CA8

5.54e-071861157a583d6fc0f1e729f6e9fd18d7b49d6eab9ca32b9
ToppCellfacs-Bladder|facs / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VSIG2 PTGS1 EHF LPIN2 CTSE GPA33 FOXF1

5.75e-071871157dd5ca59417fd1b388fd975f0f3e1f3245d66ebc5
ToppCelldroplet-Bladder|droplet / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VSIG2 PTGFRN PTGS1 EHF CTSE GPA33 CA3

6.39e-071901157170484f7a6f0a0d0792bbe1bb04abad060b7188e
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-goblet-Goblet_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VSIG2 CFAP65 NTN4 TFCP2L1 EHF GPA33 CA8

7.61e-0719511577ff04c45a02df01e3816f3c1d43585a93182a730
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-goblet|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VSIG2 CFAP65 NTN4 TFCP2L1 EHF GPA33 CA8

7.61e-07195115709605533aa5947bb2e5a6725c1ce89f79d330bf5
ToppCellLPS-IL1RA-Epithelial_alveolar-Mes-Like|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP65 NTN4 TC2N BRCA2 CA8

7.17e-061031155c11bb0238e81a42dad5d7687c9d22474129d803d
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HGF LAMC3 PTGS2 ATRNL1 FZD10 CA8

7.40e-061801156280ff5c8f292be1b88120db5ff1788b750644856
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HGF LAMC3 PTGS2 ATRNL1 FZD10 CA8

7.40e-061801156fdbd7c22044d9328a1e06e2f9a4451529d1df767
ToppCellrenal_papilla_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

HSPG2 PTGS1 ATRNL1 EHF LPIN2 CA8

7.40e-06180115649829e833fe6d2431cfd2e8f378c2aaa3b2b46a4
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A LAMC3 CHRNA4 NTN4 IRAK3 SLC25A48

7.63e-0618111562f3d04d22d4ac016e61709ea5af3d48885c946c4
ToppCellControl-Epithelial_cells-Airway_club|Control / group, cell type (main and fine annotations)

HS6ST2 TFCP2L1 EHF CTSE CA3 CA8

7.63e-061811156c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A LAMC3 NTN4 LPIN2 IRAK3 SLC25A48

8.65e-061851156487fa382232564f075960899d50afa0edae5d258
ToppCell(5)_Glands_duct|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

ANKRD66 TFCP2L1 CLDN11 FES C2 CA8

8.92e-061861156ad8d5010e5095508f4995e0c6c016a44e8ffb8dd
ToppCellCOVID-19-kidney-Mito-rich_Distal|kidney / Disease (COVID-19 only), tissue and cell type

HS6ST2 TFCP2L1 EHF PKHD1 FZD10 PRKX

9.19e-0618711562ce8038d9d1302e850c1bb536e755598f77ba4b9
ToppCelldroplet-Bladder-BLADDER-1m-Epithelial-bladder_urothelial_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VSIG2 EHF NECTIN4 CTSE GPA33 NOTCH1

9.19e-061871156aa336fb568a24e12c0454265ddd71ed10a6614cf
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A LAMC3 CHRNA4 NTN4 IRAK3 SLC25A48

9.19e-06187115602105c82a9ba79d2f19e002188377fc3440770c2
ToppCellfacs-Lung-EPCAM-3m-Epithelial-Alveolar_Epithelial_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VSIG2 TFCP2L1 TC2N EHF NECTIN4 CA8

9.48e-061881156b1049003ca79c340bb8c78da66bdc0956e1aebc2
ToppCellfacs-Lung-EPCAM-3m-Epithelial-type_II_pneumocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VSIG2 TFCP2L1 TC2N EHF NECTIN4 CA8

9.48e-0618811563dd571bd8e7358b4346dea71f6bf9602dabf583c
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PTGS1 TFCP2L1 TC2N EHF LPIN2 CA8

1.01e-0519011568ff8c586237cf15f930416710bcff45205fe6f70
ToppCellfacs-Lung-3m-Epithelial-alveolar_epithelial-type_II_pneumocyte-type_2_alveolar_epithelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VSIG2 TFCP2L1 TC2N EHF LPIN2 CA8

1.04e-051911156f98fc372e579ce69409afbbe0f83c03c7ea62632
ToppCellfacs-Lung-3m-Epithelial-alveolar_epithelial-type_II_pneumocyte|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VSIG2 TFCP2L1 TC2N EHF LPIN2 CA8

1.04e-051911156210589095a3f5d5117174caf6ec110b502f27030
ToppCellPND14-Epithelial-Epithelial_Alveolar|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PTGS1 TFCP2L1 TC2N EHF LPIN2 CA8

1.04e-0519111565f8b3b2d38b37027901db9a1cccdbd1ff70f29de
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PTGS1 TFCP2L1 TC2N EHF LPIN2 CA8

1.04e-0519111562f71f1fb6b5872d84860840b22e789a87ab14eec
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PTGS1 TFCP2L1 TC2N EHF LPIN2 CA8

1.04e-0519111564ab3056f9af2a6caed39f32288562f480811cd7b
ToppCellfacs-Lung-3m-Epithelial-alveolar_epithelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VSIG2 TFCP2L1 TC2N EHF LPIN2 CA8

1.07e-0519211564a46f7980ec145be5b4bf8b98265e3e0f2ea4c63
ToppCellTCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Endometrioid-1|TCGA-Endometrium / Sample_Type by Project: Shred V9

BARD1 EXTL3 DCLRE1B PTGS2 CHRNA5 PTPN9

1.10e-051931156c2673d86f7d7b849788036032a93a6d136a70040
ToppCelldroplet-Bladder-nan-3m-Epithelial-luminal_bladder_epithelial_cell_(umbrella_cell)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VSIG2 TC2N EHF NECTIN4 CTSE NOTCH1

1.17e-051951156d6e2a5a15bea16de5f7ff09318c67d46ea923203
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NCAM2 CSMD3 SHISA7 NTN4 ATRNL1 FZD10

1.20e-051961156f374cb3ec31c6eef2cef9e07547bfd1e380553af
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NCAM2 CSMD3 SHISA7 NTN4 ATRNL1 FZD10

1.20e-051961156671c380b58d7f634b4fbec38c357d357ea4f3535
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_1-AT1|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ACAD10 NTN4 PTPRQ PKHD1 SLC25A48 ERVFRD-1

1.27e-0519811565a85c286f79cde5811d2595a3397c6fb7685adee
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

HS6ST2 HCAR1 EHF CTSE CA3 CA8

1.27e-051981156af399569c718f5fd971d73a7926768c9311002a3
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Club|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

HS6ST2 HCAR1 EHF CTSE CA3 CA8

1.27e-0519811561408e02e053ad3406229bfe8189da03be6366e81
ToppCellLPS_anti-TNF-Hematopoietic_Erythro-Megakary-Erythro-Mega-Erythroid|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

RANBP10 PGA4 TECTA LPIN2 CTSE CA3

1.31e-051991156565404c155dfac57c020a8f2d09cbf756da20ffd
ToppCellLPS_anti-TNF-Hematopoietic_Erythro-Megakary|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

RANBP10 PGA4 TECTA LPIN2 CTSE CA3

1.31e-0519911566c174dbcc25b980f10a3d1dfe39e613acac73bb6
ToppCellLPS_anti-TNF-Hematopoietic_Erythro-Megakary-Erythro-Mega|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

RANBP10 PGA4 TECTA LPIN2 CTSE CA3

1.31e-051991156284ee9632413f6404fc0b0c7c393ad813db834f2
ToppCellLPS_IL1RA_TNF-Hematopoietic_Erythro-Megakary-Erythro-Mega-Erythroid|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

RANBP10 PGA4 DCLRE1B TECTA LPIN2 CTSE

1.35e-052001156f100edfd2b3b742458cbbf34de9c403c4d272d3c
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST-MC4R|Neuronal / cells hierarchy compared to all cells using T-Statistic

THSD7A LAMC3 NTN4 CLDN11 IRAK3 SLC25A48

1.35e-052001156c1797542541747b524c9c22c723d24c8d027d486
ToppCellBrain_organoid-organoid_Tanaka_cellReport-2m-Neuroepithelial|2m / Sample Type, Dataset, Time_group, and Cell type.

CPA4 HGF IGFN1 LAMC3 PTGS2 AOPEP

1.35e-0520011563da9441c0f1e242f0d195de47ecd4c24dfdca232
ToppCellBrain_organoid-organoid_Tanaka_cellReport-2m-Neuroepithelial-Proteoglycan-expressing_cell|2m / Sample Type, Dataset, Time_group, and Cell type.

CPA4 HGF IGFN1 LAMC3 PTGS2 AOPEP

1.35e-052001156eed2bafddcd041ef5fcc4d1d31edb8be4d83ce01
ToppCellLPS_IL1RA-Hematopoietic_Erythro-Megakary-Erythro-Mega|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

RANBP10 PGA4 DCLRE1B TECTA LPIN2 CTSE

1.35e-052001156f99e214eb680fd82a33f2b1524fbfca265d1cc42
ToppCellLPS_IL1RA-Hematopoietic_Erythro-Megakary|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

RANBP10 PGA4 DCLRE1B TECTA LPIN2 CTSE

1.35e-052001156d85074b362b11e5a523a5325d203a61aa2759a7a
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST|Neuronal / cells hierarchy compared to all cells using T-Statistic

THSD7A LAMC3 NTN4 CLDN11 IRAK3 SLC25A48

1.35e-05200115653d5e427f0cbf5cf0b63efe4ec01da302f555704
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST-MC4R-L1-2|Neuronal / cells hierarchy compared to all cells using T-Statistic

THSD7A LAMC3 NTN4 CLDN11 IRAK3 SLC25A48

1.35e-052001156a0cc84add181109bb66ba9d49c732e1790222c96
ToppCellLPS-IL1RA-Epithelial_alveolar-Mes-Like-AT1-AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TFCP2L1 HMCN2 HS6ST3 GPA33 ERVFRD-1

2.06e-051281155082b3dc312b033c9b21cf73499009a1dc049ee2b
ToppCellStriatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Col3a1_(Mural.Rgs5Acta2.Col3a1)-|Striatum / BrainAtlas - Mouse McCarroll V32

ANKRD66 VSIG2 LAMC3 ACAD10 HS6ST3

2.57e-051341155a3547a68012d879d4dfe80394eace70808722e43
ToppCellStriatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Col3a1_(Mural.Rgs5Acta2.Col3a1)|Striatum / BrainAtlas - Mouse McCarroll V32

ANKRD66 VSIG2 LAMC3 ACAD10 HS6ST3

2.57e-0513411559458e2d0dbc18d9025b66b59f3ecc2fbc5384940
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

THSD7A HCAR1 HS6ST1 HS6ST3 CA8

3.17e-051401155e64f6aa57bc069cfe970089bd1c298433bfaf771
ToppCellCOVID-19-Heart-CM_5_(RYR2-)|COVID-19 / Disease (COVID-19 only), tissue and cell type

IGFN1 SPEG KLHL30 ATRNL1 STAG3

3.62e-051441155f92e03dd784e31a9e5dbd4f4c3a6517ea19210cf
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TECTA CSMD3 PTPRQ PKHD1 CES4A

3.74e-05145115596712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCellBronchial_Biopsy-Epithelial-Goblet_1|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

CPA4 VSIG2 HCAR1 NTN4 C2

3.87e-051461155a4f2e3ea79e7154873c01739672ec6454547e6a6
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-myeloid-myeloid_granulocytic|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PTGS1 HS6ST1 IRAK3 PRKG2 ERVFRD-1

4.69e-05152115532634195048858ae84605c61e43c542d90f7cab5
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-myeloid-myeloid_granulocytic-mast_cell|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PTGS1 HS6ST1 IRAK3 PRKG2 ERVFRD-1

4.69e-0515211550eb185b2404f015efff1bd140e0c502d714720fb
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CSMD3 NTN4 TFCP2L1 KLHL30 CA8

4.69e-051521155655d47efe0608d729801f1f01668e84c1bc0675f
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Myeloid-Dendritic-conventional_dendritic_cell|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

RANBP10 SIGLEC5 LAMC3 SIGLEC10 PGA3

4.84e-051531155ee6f4770c6e35d59bdeec5b0ecb10119fa8c3ca5
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Myeloid-Dendritic|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

RANBP10 SIGLEC5 LAMC3 SIGLEC10 PGA3

4.84e-051531155a35149a0c8b4ec9ad27cc4b3d34fba3b8714a6a2
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

RANBP10 SIGLEC5 LAMC3 SIGLEC10 PGA3

4.84e-05153115590cd6efda83c0b4b80eae2c90e7ff45dfd936dc2
ToppCellCOVID-19-Heart-CM_5_(RYR2-)|Heart / Disease (COVID-19 only), tissue and cell type

IGFN1 KLHL30 ATRNL1 PTPRQ STAG3

5.15e-051551155d7e26696fd9c0a759524f331243db43059b33ed9
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo1_Itga4|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

THSD7A TECTA CSMD3 CHRNA5 KRTAP13-1

5.15e-051551155cba6f3f7742b4d5d54ad0a0ac0dd4016e73fe658
ToppCellCOVID-19-lung-Mesothelial|lung / Disease (COVID-19 only), tissue and cell type

CPA4 SPEG MST1 ATRNL1 PTPRQ

5.30e-051561155e1f563869b3bf997eaa2e756e31b53db1a478903
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Lypd1_Gpr88|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

HGF THSD7A VSIG2 PTGFRN HS6ST3

5.47e-0515711555aee90ad7aaa65fdabc23597451da5e48db8f4e6
ToppCellPBMC-Severe-cDC_1|Severe / Compartment, Disease Groups and Clusters

VSIG2 PTGFRN PHF2 TFCP2L1

5.79e-058111546d1e524f000b71c935359afc801a1d31f218fec8
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Pygm_C1ql1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

THSD7A BARD1 TECTA CSMD3 CHRNA5

6.16e-0516111553b5d7a3dab479c6959a428f3954dedd989900276
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1-AT1|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NTN4 PTPRQ PKHD1 SLC25A48 ERVFRD-1

6.16e-0516111551e17a993126e1f2a25ee7dfbb95a74ccb2a26791
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TECTA CSMD3 PTPRQ PKHD1 CES4A

6.34e-051621155bf886e22ff2a20353499004b53f25fb9e6574896
ToppCellCOVID-19-lung-Mesothelial|COVID-19 / Disease (COVID-19 only), tissue and cell type

CPA4 PTGS1 MST1 ATRNL1 PTPRQ

6.72e-05164115583303e2ba52008391b8dc3fae8225ab5bcb20063
ToppCellMild-Myeloid-Mast|Mild / Condition, Lineage, Cell class and cell subclass

HSPG2 THSD7A PTGS1 HS6ST1 PRKG2

6.92e-0516511555fa9552c37890c5cc7e672a47038aebba2413cb4
ToppCellMild-Myeloid-Mast-|Mild / Condition, Lineage, Cell class and cell subclass

HSPG2 THSD7A PTGS1 HS6ST1 PRKG2

6.92e-05165115593d3909a0f5f43d473d5005c842d7d73e25eceed
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Pygm_C1ql1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

THSD7A BARD1 CSMD3 PTGS1 CHRNA5

7.53e-051681155f3879a8e11eaf866f37c52e67021be43f0b8784a
ToppCellControl-Lymphoid-ILC_B|Lymphoid / Disease state, Lineage and Cell class

HS6ST2 FES IRAK3 SCART1 ERVFRD-1

7.53e-051681155d7118d39253ed9790908b850088ebfc5a86f4065
ToppCellP15-Epithelial-alveolar_epithelial_cell-type_II_pneumocyte|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

VSIG2 TFCP2L1 TC2N EHF CA8

7.97e-0517011556c0619cbe2f01a6de18da0a137f92bda0cbdf075
ToppCellP28-Epithelial-epithelial_progenitor_cell-epithelial_progenitor_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

VSIG2 TFCP2L1 TC2N EHF CA8

7.97e-051701155d0ed3a8a7ad96c05641ec409b0a69c4fb094893c
ToppCell3'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet-Goblet_cell|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VSIG2 CFAP65 TC2N EHF CA8

7.97e-0517011552c5a1469e5743870e96e6c2cc92f0c5096b79f51
ToppCell3'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VSIG2 CFAP65 TC2N EHF CA8

7.97e-0517011559bea81031cdfe45e8cddac3a3afd9ca6c331c45a
ToppCellprimary_visual_cortex-Non-neuronal-leptomeningeal_cell|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

HSPG2 HCAR1 LAMC3 SLC22A2 C2

8.89e-0517411552891ab2fd05eb4bbd239d1a2865f21ef7f2df39e
ToppCellprimary_visual_cortex-Non-neuronal-leptomeningeal_cell-VLMC|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

HSPG2 HCAR1 LAMC3 SLC22A2 C2

8.89e-051741155eade55f86ef1f7a5355ad65cec3aa6bfc5d3c62d
ToppCell3'-GW_trimst-1-LargeIntestine-Epithelial-Tuft-related-BEST4+_epithelial|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VSIG2 PKHD1 CTSE GPA33 CA3

9.13e-0517511558727252bcbc70bfa2ff72e7421df9cfe6fd4eed7
ToppCellP28-Epithelial-alveolar_epithelial_cell-type_II_pneumocyte|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

VSIG2 TFCP2L1 TC2N EHF CA8

9.13e-0517511558a4ed775ff973123dbcfe9c809959d11a62450c9
ToppCell3'-GW_trimst-1-LargeIntestine-Epithelial-Tuft-related|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VSIG2 PKHD1 CTSE GPA33 CA3

9.13e-051751155c083abe368e5c0dc2b0f27f375c9271a2d7ff64f
ToppCellprimary_visual_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Osr1_Mc5r|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

HSPG2 HCAR1 LAMC3 SLC22A2 C2

9.63e-051771155599cf7f5b774e197a1b43c98e4b9a8c1a618f38a
ToppCellControl-Lymphoid-ILC_B|Control / Disease state, Lineage and Cell class

HS6ST2 SCART1 LPAL2 PRKX PRKY

9.63e-0517711553d0f4b4054185ba77071efbe53df34fee84b9b24
ToppCellcellseq2-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SPEG NCAM2 PTGS1 ADGRG4 FOXF1

9.89e-0517811558ec2a25dda96c9cc9c2904b6cb18f75a293f4969
ToppCellcellseq2-Mesenchymal-Fibroblastic-Fibroblastic_2|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SPEG NCAM2 PTGS1 ADGRG4 FOXF1

9.89e-0517811556c91331196696e0cf239d105f458e3230659fa38
ToppCellAdult-Epithelial-club_cell-D122|Adult / Lineage, Cell type, age group and donor

HCAR1 EHF NECTIN4 CA3 CA8

9.89e-05178115535a2e3ba98b6f857dbb79cf8ddb4846ddcda6c17
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ANKLE2 TFCP2L1 TC2N EHF NECTIN4

1.02e-0417911556e965e424eebef50f0202cff75f458be395cfca1
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-Tuft-related-BEST4+_epithelial|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VSIG2 ADGRG4 PRKG2 CTSE GPA33

1.04e-041801155d1beaf1f106c7efaeaf61f29742d0a7310a83916
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-Tuft-related|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VSIG2 ADGRG4 PRKG2 CTSE GPA33

1.04e-041801155156b988b71f6dcf3117c1e5f4625632cb97e54f2
ToppCelldroplet-Lung-LUNG-1m-Epithelial-type_II_pneumocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VSIG2 SHISA7 TFCP2L1 EHF CA8

1.10e-041821155c1e0be27064e14043b78ae501b02d4e9542267a3
ToppCellCOVID-19-kidney-Distal_Epi_Doublet_(PCT)|COVID-19 / Disease (COVID-19 only), tissue and cell type

THSD7A TFCP2L1 SLC22A2 PKHD1 SLC25A48

1.10e-0418211559d67717a6e13bcb54c1297a3e4e3abf4e51628a3
ToppCelldroplet-Lung-LUNG-1m-Epithelial-Alveolar_Epithelial_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VSIG2 SHISA7 TFCP2L1 EHF CA8

1.10e-0418211553c9b4869d357884ae4bcd22a9872faf83a5cfc6d
ToppCellPND07-28-samps-Epithelial-Alveolar_epithelial|PND07-28-samps / Age Group, Lineage, Cell class and subclass

VSIG2 TFCP2L1 TC2N EHF CA8

1.13e-04183115523e55f88a802a9299d2773f9394970e86e8bbfaa
ToppCellPND07-28-samps-Epithelial-Alveolar_epithelial-AT2|PND07-28-samps / Age Group, Lineage, Cell class and subclass

VSIG2 TFCP2L1 TC2N EHF CA8

1.13e-0418311550a69e22750dd8b66ab988cf36d0dd2b59e2f7d26
ToppCellPND07-28-samps-Epithelial|PND07-28-samps / Age Group, Lineage, Cell class and subclass

VSIG2 TFCP2L1 TC2N EHF CA8

1.13e-041831155a98f1d71d82ed6cca996f74352ab834fb6e95206
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A LAMC3 NTN4 IRAK3 SLC25A48

1.13e-0418311556e6128c5be5e0a2db6d84eecbf4dddd02d0216f8
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A CHRNA4 NTN4 IRAK3 SLC25A48

1.13e-041831155e3ffef2b57dc5b96466dccc9cd54ba326ccf378a
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A LAMC3 NTN4 IRAK3 SLC25A48

1.13e-0418311555e361be3ae3fe05098968e58427630127bd12675
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGFN1 NCAM2 CSMD3 PTPRQ PKHD1

1.16e-0418411552cbed6462fea2622871bb7e49b0df3d984239281
ToppCell3'-GW_trimst-2-LargeIntestine-Epithelial-goblet-Goblet_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VSIG2 CFAP65 NTN4 TFCP2L1 EHF

1.16e-041841155886d2d9bf2fe31207f17e3edc309ef44029924e1
ToppCellwk_20-22-Mesenchymal-Mesothelial|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

CPA4 PTGS1 MST1 PTPRQ CTSE

1.16e-041841155804f8a41cd6b1361448872bf352bf0a38a0fac66
DrugAC1LAIK6

PTGS1 PTGS2 PRKACA PRKACB PRKACG CA3 CA8

7.64e-071011147CID000469113
DrugLY83583

PTGS1 PTGS2 PRKACA PRKACB PRKACG C2 PRKG2

9.95e-071051147CID000003976
Drugtryptanthrin

HGF PTGS1 PTGS2 C2

1.04e-06161144CID000073549
Drugproglumetacin

PGA5 PTGS1 PTGS2

2.42e-0661143CID000004921
DrugKBT-3022

F2 PTGS1 PTGS2

2.42e-0661143CID000065870
Drugoxindanac

PGA5 PTGS1 PTGS2

2.42e-0661143CID000068879
DrugS35b

F2 PTGS1 PTGS2

2.42e-0661143CID000193841
DrugAH6809

PTGS1 PTGS2 PRKACA PRKACB PRKACG

3.00e-06451145CID000119461
DrugRp-8-Br-cGMPS

PTGS1 PRKACA PRKACB PRKACG PRKG2

3.35e-06461145CID003035839
DrugSp-8-Cl-cAMPS

PRKACA PRKACB PRKACG PRKG2

4.07e-06221144CID000133987
Drugsatigrel

F2 PTGS1 PTGS2

4.22e-0671143CID000065913
DrugLMWH

HGF HSPG2 HS6ST2 LAMC3 EXTL3 F2 PGA5 CHRNA4 CFHR4 HS6ST1 PRKACA PRKACB PRKACG HS6ST3

5.88e-0666311414CID000000772
DrugH-9 dihydrochloride

LAMC3 PTGS1 PRKACA PRKACB PRKACG PRKG2

6.10e-06901146CID000003544
DrugThromboxane B2

F2 PTGS1 PTGS2

6.72e-0681143ctd:D013929
DrugAC1OCF9M

HSPG2 EXTL3 PTGS1 PTGS2

1.29e-05291144CID006918304
Drugphenylpropionic acid

CPA4 ACAD10 PTGS1 PTGS2 C2 CA3 CA8

2.14e-051671147CID000000107
Drug8-pCPT-cGMP

F2 PRKACA PRKACB PRKACG PRKG2

2.17e-05671145CID000123969
DrugN6-monobutyryl-cAMP

BTN1A1 PRKACA PRKACB PRKACG

2.18e-05331144CID000115029
DrugTolmetin

PTGS1 PTGS2

2.49e-0521142DB00500
DrugPiroxicam

PTGS1 PTGS2

2.49e-0521142DB00554
DrugFenoprofen

PTGS1 PTGS2

2.49e-0521142DB00573
DrugTenoxicam

PTGS1 PTGS2

2.49e-0521142DB00469
DrugKetorolac

PTGS1 PTGS2

2.49e-0521142DB00465
DrugNabumetone

PTGS1 PTGS2

2.49e-0521142DB00461
DrugAC1O5RN5

PTGS1 PTGS2

2.49e-0521142CID006439421
DrugTiaprofenic acid

PTGS1 PTGS2

2.49e-0521142DB01600
DrugAcetaminophen

PTGS1 PTGS2

2.49e-0521142DB00316
DrugAntrafenine

PTGS1 PTGS2

2.49e-0521142DB01419
DrugTrisalicylate-choline

PTGS1 PTGS2

2.49e-0521142DB01401
DrugAntipyrine

PTGS1 PTGS2

2.49e-0521142DB01435
Druggamma-Homolinolenic acid

PTGS1 PTGS2

2.49e-0521142DB00154
DrugSalsalate

PTGS1 PTGS2

2.49e-0521142DB01399
DrugSalicylate-sodium

PTGS1 PTGS2

2.49e-0521142DB01398
DrugMagnesium salicylate

PTGS1 PTGS2

2.49e-0521142DB01397
DrugBismuth Subsalicylate

PTGS1 PTGS2

2.49e-0521142DB01294
DrugLumiracoxib

PTGS1 PTGS2

2.49e-0521142DB01283
Drug2-methoxybenzoic acid

PTGS1 PTGS2

2.49e-0521142ctd:C081914
DrugOxaprozin

PTGS1 PTGS2

2.49e-0521142DB00991
DrugBromfenac

PTGS1 PTGS2

2.49e-0521142DB00963
DrugSuprofen

PTGS1 PTGS2

2.49e-0521142DB00870
DrugDiflunisal

PTGS1 PTGS2

2.49e-0521142DB00861
DrugCarprofen

PTGS1 PTGS2

2.49e-0521142DB00821
DrugMeloxicam

PTGS1 PTGS2

2.49e-0521142DB00814
DrugNaproxen

PTGS1 PTGS2

2.49e-0521142DB00788
DrugMefenamic acid

PTGS1 PTGS2

2.49e-0521142DB00784
DrugFlurbiprofen

PTGS1 PTGS2

2.49e-0521142DB00712
DrugMDL 035

PTGS1 PTGS2

2.49e-0521142CID000053454
Drugtricin

PTGS1 PTGS2

2.49e-0521142ctd:C017769
DrugLornoxicam

PTGS1 PTGS2

2.49e-0521142DB06725
DrugN-(3-phenoxy-4-pyridinyl)trifluoromethanesulfonamide

PTGS1 PTGS2

2.49e-0521142ctd:C468797
DrugIbuprofen

PTGS1 PTGS2

2.49e-0521142DB01050
DrugKetoprofen

PTGS1 PTGS2

2.49e-0521142DB01009
DrugSC 299

PTGS1 PTGS2

2.49e-0521142ctd:C409370
Drugflosulide

PTGS1 PTGS2

2.49e-0521142ctd:C059178
Drugcimicoxib

PTGS1 PTGS2

2.49e-0521142CID000213053
DrugMaleimides

PTGS1 PTGS2

2.49e-0521142ctd:D008301
DrugNepafenac

PTGS1 PTGS2

2.49e-0521142DB06802
Drugcicaprost

PTGS1 PTGS2 PRKACA PRKACB PRKACG

2.69e-05701145CID005311044
Drugsulprostone

PTGS1 PTGS2 PRKACA PRKACB PRKACG

2.88e-05711145CID005312153
Drug1-(5-isoquinolinesulfonyl)-2-methylpiperazine

HGF LAMC3 F2 PTGS1 PTGS2 PRKACA PRKACB PRKACG PRKG2

2.94e-053141149CID000003542
Drug8-N3cAMP

PRKACA PRKACB PRKACG

4.27e-05141143CID006426627
Drug8-(6-aminohexyl)amino cyclic AMP

PRKACA PRKACB PRKACG

4.27e-05141143CID000161999
Drugbutaprost

PTGS1 PTGS2 PRKACA PRKACB PRKACG

4.55e-05781145CID005311035
Drugsodium nitroprusside

F2 PTGS1 PTGS2 PRKACA PRKACB PRKACG C2 PRKG2

5.17e-052611148CID000045469
DrugMK-447

F2 PTGS1 PTGS2

5.32e-05151143CID000119286
DrugNA-382

PRKACA PRKACB PRKACG

5.32e-05151143CID000132534
DrugPyrilamine maleate [59-33-6]; Up 200; 10uM; PC3; HT_HG-U133A

PTCRA LAMC3 ACAD10 PTGS2 PRICKLE3 PRKX STAG3

5.58e-0519411475869_UP
Drugiloprost

F2 PTGS1 PTGS2 PRKACA PRKACB PRKACG

5.89e-051341146CID005311181
DrugSQ22536

PTGS1 PTGS2 PRKACA PRKACB PRKACG PRKG2

6.14e-051351146CID000005270
DrugPyrazines

PTGS1 PTGS2 CHRNA4

6.53e-05161143ctd:D011719
DrugVerapamyl hydrochloride [152-11-4]; Up 200; 8.2uM; MCF7; HT_HG-U133A

PDK2 SPEG EXTL3 PTGS1 PRKACA APOBEC3C PRKG2

6.55e-0519911471509_UP
Drugfirocoxib

PTGS1 PTGS2

7.43e-0531142CID000208910
Drugitazigrel

PTGS1 PTGS2

7.43e-0531142CID000051087
Drugnesodine

PTGS1 PTGS2

7.43e-0531142CID006475455
DrugMeclofenamic acid

PTGS1 PTGS2

7.43e-0531142DB00939
DrugAcetylsalicylic acid

PTGS1 PTGS2

7.43e-0531142DB00945
DrugSalicyclic acid

PTGS1 PTGS2

7.43e-0531142DB00936
DrugPhenylbutazone

PTGS1 PTGS2

7.43e-0531142DB00812
DrugEtodolac

PTGS1 PTGS2

7.43e-0531142DB00749
Drug1a, 1b-dihomo-PGF2

PTGS1 PTGS2

7.43e-0531142CID006443812
Drugmalabaricone C

PTGS1 PTGS2

7.43e-0531142ctd:C071787
Drugmalabaricone B

PTGS1 PTGS2

7.43e-0531142ctd:C071788
Drug2-propionyloxybenzoic acid

PTGS1 PTGS2

7.43e-0531142CID000095938
Drug17-hydroxy-ent-kaur-15-en-19-oic acid

PTGS1 PTGS2

7.43e-0531142CID000169654
DrugAHR-10037

PTGS1 PTGS2

7.43e-0531142CID000132843
DrugMannans

PTGS2 IRAK3

7.43e-0531142ctd:D008351
Drugzaprinast

PTGS1 PTGS2 PRKACA PRKACB PRKACG PRKG2

7.81e-051411146CID000005722
Druglonazolac

PGA5 PTGS1 PTGS2

7.90e-05171143CID000068706
Drug4,4'-diisothiocyanostilbene-2,2'-disulfonic acid

F2 PRKACA PRKACB PRKACG C2 PRKG2 CA3

8.14e-052061147CID000040600
Drug8-azido cyclic AMP

PRKACA PRKACB PRKACG

9.44e-05181143CID000115296
DrugStarlicide

F2 PRKACA PRKACB PRKACG

1.06e-04491144CID000007255
Drugvaldecoxib

EXTL3 PTGS1 PTGS2 CA3

1.06e-04491144CID000119607
Drug8-azidoadenosine

PRKACA PRKACB PRKACG

1.12e-04191143CID000160751
Drug8-thiomethyl-cAMP

PRKACA PRKACB PRKACG

1.12e-04191143CID000093140
DrugCGS 13080

F2 PTGS1 PTGS2

1.12e-04191143CID000055390
DrugWEB 2170

HGF F2 PTGS1 PTGS2

1.15e-04501144CID000065923
Drugtriethylamine

PRKACA PRKACB PRKACG PRKG2

1.15e-04501144CID000008471
DrugN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide

HGF F2 PTGS1 PTGS2 CHRNA4

1.23e-04961145ctd:C080955
DrugTacrine

HGF PTGS2 CHRNA4 SLC22A2

1.44e-04531144ctd:D013619
DrugFc 6

TFCP2 C2

1.48e-0441142CID011963939
Diseasegliosarcoma (biomarker_via_orthology)

PTGS1 PTGS2

1.35e-0521092DOID:3071 (biomarker_via_orthology)
Diseaseglioblastoma (biomarker_via_orthology)

PTGS1 PTGS2

8.07e-0541092DOID:3068 (biomarker_via_orthology)
DiseaseIntrahepatic Cholangiocarcinoma

PTGS2 PRKACA PRKACB

9.38e-05241093C0345905
DiseaseExtrahepatic Cholangiocarcinoma

PTGS2 PRKACA PRKACB

9.38e-05241093C3805278
Diseasecalcium measurement

CPA4 HGF MFSD6 ZMYM2 TC2N PRICKLE3 AOPEP SLC22A2 EHF L3MBTL3

1.14e-0462810910EFO_0004838
DiseaseCholangiocarcinoma

PTGS2 PRKACA PRKACB

1.20e-04261093C0206698
DiseaseIntestinal Polyps

PTGS1 PTGS2

1.34e-0451092C0021846
Disease1,5 anhydroglucitol measurement

PCDHA11 NCAM2 PCDHA5

1.67e-04291093EFO_0008009
Diseasenicotine dependence (is_implicated_in)

CHRNA4 CHRNA5

2.01e-0461092DOID:0050742 (is_implicated_in)
Diseaseulcerative colitis (implicated_via_orthology)

PTGS1 PTGS2

2.81e-0471092DOID:8577 (implicated_via_orthology)
Diseaseadenocarcinoma (implicated_via_orthology)

PTGS2 NOTCH1

2.81e-0471092DOID:299 (implicated_via_orthology)
Diseaselipoprotein A measurement, apolipoprotein A 1 measurement

SLC22A2 LPAL2

2.81e-0471092EFO_0004614, EFO_0006925
DiseaseReperfusion Injury

HGF PTGS1 PTGS2 IRAK3

3.38e-04891094C0035126
Diseaseparental longevity

NCAM2 DCLRE1B CHRNA4 CHRNA5 SLC22A2 FES LPAL2 HS6ST3

5.06e-044941098EFO_0007796
DiseaseCreutzfeldt-Jakob disease (is_marker_for)

PTGS1 PTGS2

5.97e-04101092DOID:11949 (is_marker_for)
DiseaseAsthma, Occupational

PTGS1 PTGS2

5.97e-04101092C0264423
Diseaseesophagus squamous cell carcinoma (is_implicated_in)

CHRNA5 BRCA2 FES

6.21e-04451093DOID:3748 (is_implicated_in)
DiseaseThrombus

HGF F2 PTGS2

6.63e-04461093C0087086
Diseasecryptic phenotype measurement

CHRNA4 CHRNA5 FES

7.06e-04471093EFO_0021487
DiseaseAdrenal Gland Neoplasms

PTGS2 PRKACA

7.28e-04111092C0001624
DiseaseAdrenal Cancer

PTGS2 PRKACA

7.28e-04111092C0750887
DiseaseThrombosis

HGF F2 PTGS2

7.98e-04491093C0040053
Diseasealcohol use disorder (implicated_via_orthology)

CHRNA4 PRKACA PRKACB PRKACG NOTCH1

8.02e-041951095DOID:1574 (implicated_via_orthology)
DiseaseTOBACCO ADDICTION, SUSCEPTIBILITY TO (finding)

CHRNA4 CHRNA5

8.71e-04121092C1861063
DiseaseNonsyndromic Hearing Loss and Deafness, Autosomal Recessive

HGF TECTA PTPRQ

8.98e-04511093cv:CN043650
Diseasenervous system disorder

PTGS2 CHRNA4 NOTCH1

1.00e-03531093C0027765
Diseasesystemic scleroderma (is_marker_for)

HGF F2 PTGS2

1.00e-03531093DOID:418 (is_marker_for)
Diseasehyperglycemia (is_marker_for)

HSPG2 F2

1.03e-03131092DOID:4195 (is_marker_for)
DiseaseConnective Tissue Diseases

SLC39A13 NOTCH1

1.03e-03131092C0009782
Diseaserenal cell carcinoma (biomarker_via_orthology)

PTGS1 PTGS2

1.20e-03141092DOID:4450 (biomarker_via_orthology)
DiseaseHereditary Breast and Ovarian Cancer Syndrome

BARD1 BRCA2

1.20e-03141092C0677776
DiseaseBarrett Epithelium

HGF PTGS2

1.57e-03161092C1258085
DiseaseBarrett Esophagus

HGF PTGS2

1.57e-03161092C0004763
Diseasecholangiocarcinoma (is_marker_for)

HGF PTGS2 NOTCH1

1.73e-03641093DOID:4947 (is_marker_for)
DiseaseGastric ulcer

PTGS1 PTGS2

1.99e-03181092C0038358
Diseasecholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement

RANBP10 HCAR1 SLC22A2 LPAL2 L3MBTL3

2.12e-032431095EFO_0004612, EFO_0020944
DiseaseCardiomyopathies, Primary

HGF PDK2 PTGS2

2.15e-03691093C0033141
DiseaseMyocardial Diseases, Secondary

HGF PDK2 PTGS2

2.15e-03691093C0036529
Diseasebipolar disorder (is_marker_for)

PTGS1 PTGS2

2.22e-03191092DOID:3312 (is_marker_for)
Diseasecarotid artery disease (is_marker_for)

HGF HSPG2

2.22e-03191092DOID:3407 (is_marker_for)
DiseaseHereditary Non-Polyposis Colon Cancer Type 2

BARD1 MLH3

2.22e-03191092C1333991
DiseaseColorectal cancer, hereditary nonpolyposis, type 1

BARD1 MLH3

2.22e-03191092C2936783
Diseasebody surface area

ACAD10 ATP13A2 SLC39A13 AOPEP PKHD1 PRKG2 HS6ST3 L3MBTL3

2.69e-036431098EFO_0022196
DiseaseBREAST CANCER

BARD1 BRCA2

2.71e-03211092114480
Diseasenon-small cell lung carcinoma

CHRNA5 BRCA2 LINC00114

2.73e-03751093EFO_0003060
DiseaseNonsyndromic genetic hearing loss

HGF TECTA PTPRQ

2.83e-03761093cv:C5680182
DiseaseEsophageal Neoplasms

PTGS1 PTGS2 MLH3

3.05e-03781093C0014859
Diseasenicotine dependence

CHRNA4 CHRNA5 SLC25A48

3.05e-03781093EFO_0003768
DiseaseMalignant neoplasm of esophagus

PTGS1 PTGS2 MLH3

3.05e-03781093C0546837
DiseaseMammary Carcinoma, Human

BARD1 PTGS1 PTGS2 MST1 BRCA2 L3MBTL3 NOTCH1

3.40e-035251097C4704874
DiseaseMammary Neoplasms, Human

BARD1 PTGS1 PTGS2 MST1 BRCA2 L3MBTL3 NOTCH1

3.40e-035251097C1257931
DiseaseMammary Neoplasms

BARD1 PTGS1 PTGS2 MST1 BRCA2 L3MBTL3 NOTCH1

3.47e-035271097C1458155

Protein segments in the cluster

PeptideGeneStartEntry
DPSLQPWSVSYDGGS

CA3

41

P07451
QPGCSYPTSWLSSQE

LINC00114

6

Q6XXX2
WTPPAIYKSSCSIDV

CHRNA4

151

P43681
AVLCYSPSDRQSWPS

ANKLE2

861

Q86XL3
TGCPVCYTPAWIQDL

BARD1

81

Q99728
PYSSSQDCVWLITVP

CSMD2

2201

Q7Z408
GFPGNYPSSLDCTWT

CSMD3

2126

Q7Z407
CLECTSVGWYPEPQV

BTN1A1

161

Q13410
YGTLSPTTPFCWIKD

ADGRG4

2876

Q8IZF6
YTSWSPCPDCAGEVA

APOBEC3C

91

Q9NRW3
YGARPCLVTSVGWTP

ANKRD66

66

B4E2M5
SQWCPTGSRSYSSVP

ACAD10

626

Q6JQN1
SVTWTSDQSGRPCVY

AOPEP

256

Q8N6M6
SSTWARPLYCSPITA

DCLRE1B

41

Q9H816
DAFSLLAYSDPWSCP

RANBP10

541

Q6VN20
KAWIYCESLSGPAPS

TP53I13

141

Q8NBR0
CIASGYPTPDISWSK

HSPG2

3596

P98160
ATWYTLTVPGDSPCA

RABEPK

16

Q7Z6M1
IGWASYAPDPTGATC

RRH

161

O14718
YAPDPTGATCTINWR

RRH

166

O14718
LSWPDYGVPSSAASL

PTPN9

466

P43378
CYNPVTDAWSVIASP

KLHL30

441

Q0D2K2
AYWTSPPGCPTVFSE

L3MBTL3

86

Q96JM7
GSSNLWVPSVYCSSL

PGA5

96

P0DJD9
PTLVCSRAVGSWSYS

PCDHA11

736

Q9Y5I1
YGPSPATDGTWTNLA

PTCRA

76

Q6ISU1
TWTLCGTPEYLAPEI

PRKACA

196

P17612
PSGWTGLYCDVPSVS

NOTCH1

1086

P46531
TCQSKEGSPTPQYSW

GPA33

161

Q99795
SCETDALPEPTVTWY

HMCN2

3061

Q8NDA2
LYFKPTWVGCSSTSP

CFAP65

886

Q6ZU64
YPSPASRLCKSSGQW

C2

56

P06681
VSTSSACVWQLAYPP

LBHD1

51

Q9BQE6
DTGSSNLWVPSVYCT

CTSE

96

P14091
TDCILSDTSPSFPWY

MLH3

706

Q9UHC1
RYSWSGEPLFLTCPT

PDCD2L

266

Q9BRP1
ATTYPPGCLQESWGQ

CES4A

81

Q5XG92
CSPAYWKPSTFGGEV

PTGS2

526

P35354
WDYCPISRCEGDTTP

HGF

461

P14210
SSSCEESWFPKYIVP

IRAK3

536

Q9Y616
PTLLCSSAVGSWSYS

PCDHA5

736

Q9Y5H7
TGYSGPNCTIPGLWT

PTGS1

61

P23219
WAACISYLSAAVPPE

MFSD6

551

Q6ZSS7
LPPCYEGTDWSGCTL

HS6ST1

221

O60243
LPTCYPGDDWSGVSL

HS6ST3

281

Q8IZP7
KTWTFCGTPEYVAPE

PRKG2

606

Q13237
WTAVYLPASSPCTLG

MTMR4

566

Q9NYA4
WCVPSTEPKNTSTYR

PDK2

391

Q15119
GSSNLWVPSVYCSSL

PGA3

96

P0DJD8
WSEPAVITGPTCYLI

PTPRQ

1601

Q9UMZ3
GDGTRDPCLPYSWIS

POP1

401

Q99575
SGCASEEYAWVPPGL

PRICKLE3

86

O43900
TESPCALVASQYGWS

HSP90B1

641

P14625
RSYGDLSPPCSNWVE

BTBD18

621

B2RXH4
SCAPLCTPGVDVYWS

FZD10

206

Q9ULW2
GTVTWTPPANYKSSC

CHRNA5

156

P30532
SVSSVRLSGYCGSPW

ATP13A2

31

Q9NQ11
TWTLCGTPEYLAPEI

PRKACB

196

P22694
TWTLCGTPEYLAPEI

PRKACG

196

P22612
WSTPTKDCTSGPYTA

BRCA2

3191

P51587
PPAWTDSYSTCNVSS

EHF

21

Q9NZC4
TVTDFYRSWNCAPGP

EXTL3

596

O43909
CTTVYPASGSSIDWA

CPA4

356

Q9UI42
WVYEGSLTIPPCSEG

CA8

216

P35219
STNDWVVTCGYTIPT

CLDN11

26

O75508
PYGQCLEWQTATCSP

ATRNL1

926

Q5VV63
YVTCSNGDWSEPPRC

CFHR4

251

Q92496
SNYVTCSNGEWSEPP

CFHR4

496

Q92496
PTSEELPSCYTGDDW

HS6ST2

356

Q96MM7
LYFLWTVPSSACDPS

HCAR1

241

Q9BXC0
WEPTSCQTSYVESSP

KRTAP13-1

61

Q8IUC0
WEPTSCQTSYVESSP

KRTAP13-2

61

Q52LG2
WLPCHVGTVPVTTYT

IGFN1

891

Q86VF2
GPWCYTTDPAVRFQS

MST1

166

P26927
ILTCDPATPAASYQW

PSG4

166

Q00888
PCRDGWVYETPGSSI

SLC22A2

121

O15244
LPEAWAYTCSASPGG

SLC39A13

126

Q96H72
YFSIISPKEWGTSCP

C1orf50

131

Q9BV19
GSSNLWVPSVYCSSL

PGA4

96

P0DJD7
CWAYEPGQRPSFSTI

FES

796

P07332
YYCSVTPWVKSPTGS

PTGFRN

791

Q9P2B2
AVYSGSAAAWPPSAS

FOXF1

261

Q12946
TFYECPSTAPWEPVG

RTL1

606

A6NKG5
ECTISASSPLYPAFW

RNF135

401

Q8IUD6
YGDPTLCPTWATDAL

QTRT1

381

Q9BXR0
PSGWIYATLTPVDCL

PHF2

316

O75151
DCIVTPYSDWTSCPS

THSD7A

771

Q9UPZ6
QCRDLSWPSSYGDTP

TC2N

246

Q8N9U0
DCSAGPWCYTTDPNV

LPAL2

81

Q16609
LYPESWTDRGCTCPI

NTN4

566

Q9HB63
TWTLCGTPEYLAPEV

PRKY

201

O43930
VYSLPQLLGPSCSWE

SIGLEC5

331

O15389
ASCSNYDTPRWATTP

SHISA7

126

A6NL88
GSPPVYSVTSWLAGC

PKHD1

736

P08F94
YSVTSWLAGCGTELP

PKHD1

741

P08F94
FLSEWITPEACTGPS

SLC25A48

201

Q6ZT89
QPSYETTILTECSPW

TFCP2L1

246

Q9NZI6
TTILTECSPWPDVAY

TFCP2L1

251

Q9NZI6
WPSSLGITDCCQYVT

ANGEL1

481

Q9UNK9
GWRNYTSCTVTCPPN

TECTA

1361

O75443
CRVSSSPAPAVSWLY

NCAM2

136

O15394
VLWKPGDSRAPCTYT

SPEG

2696

Q15772
WGPVTTYCHSLSPVE

STAG3

1046

Q9UJ98
SNWTGTCTIGYVTPD

ERVFRD-1

311

P60508
QPSYETTILTECSPW

TFCP2

266

Q12800
TTILTECSPWPEITY

TFCP2

271

Q12800
LDPLYPSRCSWETFG

TMEM94

1021

Q12767
PISSVERYDPAAGCW

KBTBD13

271

C9JR72
ESYLWNCPVSTLGAP

SCART1

401

Q4G0T1
TWTLCGTPEYLAPEV

PRKX

201

P51817
LGACVLSSPYDVPTW

PSME4

1766

Q14997
YLQPECSSSTDSPVW

ZMYM2

1326

Q9UBW7
DSSTTGPWCYTTDPT

F2

161

P00734
CSFSYPRQDWTGSTP

SIGLEC10

41

Q96LC7
CSSSEGAPKPVYNWV

VSIG2

166

Q96IQ7
PGYVVPCNCTAWSAS

SOX14

196

O95416
STCTWYLGTSGIQPV

TM7SF3

106

Q9NS93
PASWVEICSCPTGYT

LAMC3

666

Q9Y6N6
GDWSPLETTYPQTAC

LPIN2

226

Q92539
CTAEGSPAPSVTWDT

NECTIN4

171

Q96NY8