Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	PP2A_PR55	PPP2R2A PPP2R2B	1.25e-04	4	86	2	IPR000009
Domain	MAGUK_N_PEST	DLG3 DLG4	1.25e-04	4	86	2	PF10608
Domain	PDZ_assoc	DLG3 DLG4	1.25e-04	4	86	2	PF10600
Domain	PP2A_PR55_CS	PPP2R2A PPP2R2B	1.25e-04	4	86	2	IPR018067
Domain	DLG1_PEST_dom	DLG3 DLG4	1.25e-04	4	86	2	IPR019590
Domain	PDZ_assoc	DLG3 DLG4	1.25e-04	4	86	2	IPR019583
Domain	KN_motif	KANK1 KANK2	1.25e-04	4	86	2	IPR021939
Domain	MAGUK_N_PEST	DLG3 DLG4	1.25e-04	4	86	2	SM01277
Domain	DLG1	DLG3 DLG4	1.25e-04	4	86	2	IPR016313
Domain	KN_motif	KANK1 KANK2	1.25e-04	4	86	2	PF12075
Domain	PR55_2	PPP2R2A PPP2R2B	1.25e-04	4	86	2	PS01025
Domain	PR55_1	PPP2R2A PPP2R2B	1.25e-04	4	86	2	PS01024
Domain	Pept_M16_Zn_BS	IDE UQCRC2	4.34e-04	7	86	2	IPR001431
Domain	Pept_M16_dom	IDE UQCRC2	4.34e-04	7	86	2	IPR011237
Domain	Metalloenz_LuxS/M16	IDE UQCRC2	4.34e-04	7	86	2	IPR011249
Domain	Peptidase_M16_C	IDE UQCRC2	4.34e-04	7	86	2	PF05193
Domain	Pept_M16_N	IDE UQCRC2	4.34e-04	7	86	2	IPR011765
Domain	Peptidase_M16	IDE UQCRC2	4.34e-04	7	86	2	PF00675
Domain	-	IDE UQCRC2	4.34e-04	7	86	2	3.30.830.10
Domain	Peptidase_M16_C	IDE UQCRC2	4.34e-04	7	86	2	IPR007863
Domain	INSULINASE	IDE UQCRC2	4.34e-04	7	86	2	PS00143
Pathway	REACTOME_SYNAPTIC_ADHESION_LIKE_MOLECULES	GRIA3 DLG3 DLG4	7.55e-05	20	59	3	MM15485
Pathway	REACTOME_SYNAPTIC_ADHESION_LIKE_MOLECULES	GRIA3 DLG3 DLG4	8.78e-05	21	59	3	M27736
Pathway	REACTOME_UNBLOCKING_OF_NMDA_RECEPTORS_GLUTAMATE_BINDING_AND_ACTIVATION	GRIA3 DLG3 DLG4	8.78e-05	21	59	3	M838
Pathway	REACTOME_UNBLOCKING_OF_NMDA_RECEPTORS_GLUTAMATE_BINDING_AND_ACTIVATION	GRIA3 DLG3 DLG4	1.01e-04	22	59	3	MM15104
Pathway	REACTOME_NRCAM_INTERACTIONS	DLG3 DLG4	3.57e-04	7	59	2	M27378
Pathway	REACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS	GRIA3 DLG3 DLG4	4.14e-04	35	59	3	MM15109
Pubmed	Combined analysis of exon splicing and genome wide polymorphism data predict schizophrenia risk loci.	BICD2 ZC3H13 DLG3	1.61e-07	5	89	3	24507884
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	PPP2R2A ZNF609 THADA PTPN14 TCF12 DCDC1 EP400 ERC1 SCML1 PCDH19 DLG4 CRYBG3 KANK2	5.24e-06	1116	89	13	31753913
Pubmed	Identification of the adenovirus E4orf4 protein binding site on the B55α and Cdc55 regulatory subunits of PP2A: Implications for PP2A function, tumor cell killing and viral replication.	PPP2R2A PPP2R2B	6.48e-06	2	89	2	24244166
Pubmed	Differential trafficking of AMPA and NMDA receptors by SAP102 and PSD-95 underlies synapse development.	DLG3 DLG4	6.48e-06	2	89	2	19104036
Pubmed	A mechano-signalling network linking microtubules, myosin IIA filaments and integrin-based adhesions.	KANK1 KANK2	6.48e-06	2	89	2	31114072
Pubmed	Synapse-associated protein 102/dlgh3 couples the NMDA receptor to specific plasticity pathways and learning strategies.	DLG3 DLG4	6.48e-06	2	89	2	17344405
Pubmed	Clustered gene expression changes flank targeted gene loci in knockout mice.	DLG3 DLG4	6.48e-06	2	89	2	18074027
Pubmed	Synaptic state-dependent functional interplay between postsynaptic density-95 and synapse-associated protein 102.	DLG3 DLG4	6.48e-06	2	89	2	23946397
Pubmed	Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	KLHL1 DCDC1 EP400 ALPK1 KANK2	7.04e-06	103	89	5	10819331
Pubmed	An integrated workflow for charting the human interaction proteome: insights into the PP2A system.	PPP4R1 PPP2R2A PPP2R2B MYO9A ZC3HAV1	7.73e-06	105	89	5	19156129
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	BICD2 KANK1 TCF20 EP400 ERC1 DOCK9 PCDH19 DLG3	1.01e-05	407	89	8	12693553
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	PPP2R2B ANK2 PCDH19 GRIA3 DLG3 DLG4	1.20e-05	197	89	6	36604605
Pubmed	A brain atlas of synapse protein lifetime across the mouse lifespan.	DLG3 DLG4	1.94e-05	3	89	2	36202095
Pubmed	SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family.	DLG3 DLG4	1.94e-05	3	89	2	9581761
Pubmed	Morphine has an antinociceptive effect through activation of the okadaic-acid-sensitive Ser/Thr protein phosphatases PP 2 A and PP5 estimated by tail-pinch test in mice.	PPP2R2A PPP2R2B	1.94e-05	3	89	2	16102737
Pubmed	Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform.	PPP2R2A PPP2R2B	1.94e-05	3	89	2	1849734
Pubmed	Peptidylarginine deiminase isoforms 1-3 are expressed in the epidermis and involved in the deimination of K1 and filaggrin.	FLG PADI3	1.94e-05	3	89	2	15675958
Pubmed	Association of liprin β-1 with kank proteins in melanoma.	KANK1 KANK2	1.94e-05	3	89	2	26739330
Pubmed	Structural basis for the recognition of kinesin family member 21A (KIF21A) by the ankyrin domains of KANK1 and KANK2 proteins.	KANK1 KANK2	1.94e-05	3	89	2	29183992
Pubmed	Pooled genetic analysis identifies variants that confer enhanced susceptibility to PCOS in Indian ethnicity.	THADA IDE	1.94e-05	3	89	2	32416252
Pubmed	MAGUKs are essential, but redundant, in long-term potentiation.	DLG3 DLG4	1.94e-05	3	89	2	34244435
Pubmed	Postsynaptic density scaffold SAP102 regulates cortical synapse development through EphB and PAK signaling pathway.	DLG3 DLG4	1.94e-05	3	89	2	23486974
Pubmed	Developmental disruption and restoration of brain synaptome architecture in the murine Pax6 neurodevelopmental disease model.	DLG3 DLG4	1.94e-05	3	89	2	36369219
Pubmed	Architecture of the Mouse Brain Synaptome.	DLG3 DLG4	1.94e-05	3	89	2	30078578
Pubmed	The association of GPR85 with PSD-95-neuroligin complex and autism spectrum disorder: a molecular analysis.	DLG3 DLG4	1.94e-05	3	89	2	25780553
Pubmed	Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins.	DLG3 DLG4	1.94e-05	3	89	2	17046693
Pubmed	Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits.	PPP2R2A PPP2R2B	1.94e-05	3	89	2	9514514
Pubmed	Calcium-permeable AMPA receptors and silent synapses in cocaine-conditioned place preference.	DLG3 DLG4	1.94e-05	3	89	2	28077487
Pubmed	Interaction of NE-dlg/SAP102, a neuronal and endocrine tissue-specific membrane-associated guanylate kinase protein, with calmodulin and PSD-95/SAP90. A possible regulatory role in molecular clustering at synaptic sites.	DLG3 DLG4	1.94e-05	3	89	2	10026200
Pubmed	Acefylline activates filaggrin deimination by peptidylarginine deiminases in the upper epidermis.	FLG PADI3	1.94e-05	3	89	2	26616205
Pubmed	Standardized experiments in mutant mice reveal behavioural similarity on 129S5 and C57BL/6J backgrounds.	DLG3 DLG4	1.94e-05	3	89	2	27886459
Pubmed	Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.	THADA TCF20 IDE	2.08e-05	21	89	3	18591388
Pubmed	Underlying genetic models of inheritance in established type 2 diabetes associations.	THADA TCF20 IDE	2.08e-05	21	89	3	19602701
Pubmed	PTPN14 is required for the density-dependent control of YAP1.	WWC2 PPP2R2A PTPN14	2.08e-05	21	89	3	22948661
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	PPP4R1 THADA MYO9A ERC1 DOCK9 TRAPPC10 LAMC3 ZNF79 ZMYM1 TBC1D17 ZC3HAV1	2.45e-05	925	89	11	28986522
Pubmed	Tagging genes with cassette-exchange sites.	PPP2R2A DOCK9 UBR4 MTSS1 NAV2 ZMYM1 DMXL1	2.53e-05	335	89	7	15741177
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	FLG PPP2R2A ZNF609 THADA PTPN14 ERC1 GDAP2 SCML1 TRAPPC10 VSIG8 UQCRC2 BBS12 ZC3HAV1	3.11e-05	1321	89	13	27173435
Pubmed	High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes.	GRIA3 DLG3 DLG4	3.15e-05	24	89	3	22632720
Pubmed	Transcription factor Tcf4 is the preferred heterodimerization partner for Olig2 in oligodendrocytes and required for differentiation.	TCF12 ANK2 MYRF	3.58e-05	25	89	3	32266943
Pubmed	KANK deficiency leads to podocyte dysfunction and nephrotic syndrome.	KANK1 KANK2	3.87e-05	4	89	2	25961457
Pubmed	Kank proteins: structure, functions and diseases.	KANK1 KANK2	3.87e-05	4	89	2	19554261
Pubmed	Kank proteins: a new family of ankyrin-repeat domain-containing proteins.	KANK1 KANK2	3.87e-05	4	89	2	17996375
Pubmed	X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes.	GRIA3 DLG3	3.87e-05	4	89	2	25644381
Pubmed	Interaction of the tyrosine kinase Pyk2 with the N-methyl-D-aspartate receptor complex via the Src homology 3 domains of PSD-95 and SAP102.	DLG3 DLG4	3.87e-05	4	89	2	12576483
Pubmed	Cypin: a cytosolic regulator of PSD-95 postsynaptic targeting.	DLG3 DLG4	3.87e-05	4	89	2	10595517
Pubmed	Expression pattern of membrane-associated guanylate kinases in interneurons of the visual cortex.	DLG3 DLG4	3.87e-05	4	89	2	21031555
Pubmed	Synaptic scaffold evolution generated components of vertebrate cognitive complexity.	DLG3 DLG4	3.87e-05	4	89	2	23201973
Pubmed	Profile of cortical N-methyl-D-aspartate receptor subunit expression associates with inherent motor impulsivity in rats.	DLG3 DLG4	3.87e-05	4	89	2	31295463
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	WWC2 PPP2R2A PTPN14 UBR4 DLG4 IDE UQCRC2 SIX4 PPEF1 KANK2 ZC3HAV1	3.92e-05	974	89	11	28675297
Pubmed	Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release.	ERC1 DLG4 UNC13C	4.04e-05	26	89	3	17124501
Pubmed	Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight.	THADA TCF20 IDE	4.53e-05	27	89	3	20490451
Pubmed	Obesity and diabetes genetic variants associated with gestational weight gain.	THADA TCF20 IDE	5.64e-05	29	89	3	20816152
Pubmed	Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95.	DLG3 DLG4	6.44e-05	5	89	2	11134026
Pubmed	Phase Separation-Mediated TARP/MAGUK Complex Condensation and AMPA Receptor Synaptic Transmission.	GRIA3 DLG4	6.44e-05	5	89	2	31492534
Pubmed	Selective interaction of megalin with postsynaptic density-95 (PSD-95)-like membrane-associated guanylate kinase (MAGUK) proteins.	DLG3 DLG4	6.44e-05	5	89	2	12713445
Pubmed	Activation of protein phosphatase-2A1 by HIV-1 Vpr cell death causing peptide in intact CD(4+) T cells and in vitro.	PPP2R2A PPP2R2B	6.44e-05	5	89	2	15578586
Pubmed	The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses.	DLG3 DLG4	6.44e-05	5	89	2	10725395
Pubmed	Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif.	DLG3 DLG4	6.44e-05	5	89	2	26352593
Pubmed	Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40.	PPP2R2A PPP2R2B	6.44e-05	5	89	2	17529992
Pubmed	SAP90 binds and clusters kainate receptors causing incomplete desensitization.	DLG3 DLG4	6.44e-05	5	89	2	9808460
Pubmed	Insulin receptor substrate of 53 kDa links postsynaptic shank to PSD-95.	DLG3 DLG4	6.44e-05	5	89	2	15255944
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PPP4R1 WWC2 PPP2R2A ZNF609 PTPN14 ERC1 IDE UQCRC2 CRYBG3 SIX4 PPEF1	7.61e-05	1049	89	11	27880917
Pubmed	NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex.	DLG3 DLG4	9.65e-05	6	89	2	12738960
Pubmed	Ep400 deficiency in Schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy.	ANK2 EP400	9.65e-05	6	89	2	31142747
Pubmed	Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes.	DLG3 DLG4	9.65e-05	6	89	2	11572861
Pubmed	Plasma membrane Ca2+-atpase isoforms 2b and 4b interact promiscuously and selectively with members of the membrane-associated guanylate kinase family of PDZ (PSD95/Dlg/ZO-1) domain-containing proteins.	DLG3 DLG4	9.65e-05	6	89	2	11274188
Pubmed	PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2.	DLG3 DLG4	9.65e-05	6	89	2	22246437
Pubmed	Disruption of the NMDA receptor-PSD-95 interaction in hippocampal neurons with no obvious physiological short-term effect.	DLG3 DLG4	9.65e-05	6	89	2	14529713
Pubmed	Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis.	DLG3 DLG4	9.65e-05	6	89	2	19118189
Pubmed	Proteasome-independent polyubiquitin linkage regulates synapse scaffolding, efficacy, and plasticity.	DLG3 DLG4	9.65e-05	6	89	2	28973854
Pubmed	Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission.	GRIA3 DLG4	9.65e-05	6	89	2	16990550
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	THADA HEG1 EP400 DOCK9 UBR4 NAV2 LAMC3 GPC2 MYRF TBC1D17 FANCA	1.20e-04	1105	89	11	35748872
Pubmed	Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).	THADA KLHL1 CSMD2	1.28e-04	38	89	3	22952603
Pubmed	HSF1 transcriptional activity is modulated by IER5 and PP2A/B55.	PPP2R2A PPP2R2B	1.35e-04	7	89	2	25816751
Pubmed	CKAMP44: a brain-specific protein attenuating short-term synaptic plasticity in the dentate gyrus.	GRIA3 DLG4	1.35e-04	7	89	2	20185686
Pubmed	Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition.	GRIA3 DLG4	1.35e-04	7	89	2	33981040
Pubmed	Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning.	DLG3 DLG4	1.35e-04	7	89	2	19243221
Pubmed	Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking.	GRIA3 DLG4	1.35e-04	7	89	2	17093100
Pubmed	Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses.	DLG3 DLG4	1.35e-04	7	89	2	11997254
Pubmed	SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density.	DLG3 DLG4	1.35e-04	7	89	2	9115257
Pubmed	Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones.	ERC1 UNC13C	1.35e-04	7	89	2	36398873
Pubmed	A novel family of adhesion-like molecules that interacts with the NMDA receptor.	DLG3 DLG4	1.35e-04	7	89	2	16495444
Pubmed	Polarity protein complex Scribble/Lgl/Dlg and epithelial cell barriers.	DLG3 DLG4	1.79e-04	8	89	2	23397623
Pubmed	The G protein-coupled receptor CL1 interacts directly with proteins of the Shank family.	DLG3 DLG4	1.79e-04	8	89	2	10958799
Pubmed	The serotonin 5-HT2A and 5-HT2C receptors interact with specific sets of PDZ proteins.	DLG3 DLG4	1.79e-04	8	89	2	14988405
Pubmed	Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest.	PPP2R2A PPP2R2B	1.79e-04	8	89	2	11956189
Pubmed	Btbd11 supports cell-type-specific synaptic function.	DLG3 DLG4	1.79e-04	8	89	2	37261953
Pubmed	The role of Vpr in HIV-1 pathogenesis.	PPP2R2A PPP2R2B	1.79e-04	8	89	2	15638722
Pubmed	A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55.	PPP2R2A PPP2R2B	1.79e-04	8	89	2	17245430
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	MYO9A ERC1 SCML1 CRYBG3 KANK2	2.06e-04	209	89	5	36779422
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	PPP2R2A ZNF609 TCF20 EP400 CRYBG3 SIX4 KANK2	2.14e-04	472	89	7	38943005
Pubmed	Proteomic profiling of Myc-associated proteins.	PTPN14 TCF12 EP400 ERC1	2.16e-04	114	89	4	21150319
Pubmed	Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye.	PPP2R2A PPP2R2B	2.30e-04	9	89	2	18432318
Pubmed	Loss of postsynaptic GABA(A) receptor clustering in gephyrin-deficient mice.	GRIA3 DLG4	2.30e-04	9	89	2	10531433
Pubmed	Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems.	DLG3 DLG4	2.30e-04	9	89	2	17526495
Pubmed	Akt-dependent Pp2a activity is required for epidermal barrier formation during late embryonic development.	PPP2R2A PPP2R2B	2.30e-04	9	89	2	19762425
Pubmed	Binding of neuroligins to PSD-95.	DLG3 DLG4	2.30e-04	9	89	2	9278515
Pubmed	The nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activity.	DLG3 DLG4	2.30e-04	9	89	2	17938206
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	ZNF823 PPP2R2B TCF20 ADAMTS6 UBR4 C5 IDE CSMD2	2.35e-04	638	89	8	31182584
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	PPP4R1 ZNF609 TCF12 UQCRC2 CRYBG3 TBC1D17 ZC3HAV1 FANCA	2.67e-04	650	89	8	38777146
GeneFamily	Ankyrin repeat domain containing\|KN motif and ankyrin repeat domain containing	KANK1 KANK2	7.84e-05	4	66	2	623
GeneFamily	WD repeat domain containing\|Protein phosphatase 2 regulatory subunits	PPP2R2A PPP2R2B	1.34e-03	15	66	2	696
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	DPP6 ZNF609 KANK1 TCF12 MYO9A ERC1 NAV2 ZNF407	5.87e-09	196	89	8	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	DPP6 ZNF609 KANK1 TCF12 MYO9A ERC1 NAV2 ZNF407	6.36e-09	198	89	8	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	LPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_only / Treatment groups by lineage, cell group, cell type	EPHB3 DPP6 WWC2 MYO9A ATOH8 NAV2 C5 MYRF	6.88e-09	200	89	8	2dadf317a42a7e27cc1fac74f91b806c93a57108
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DPP6 WWC2 MYO9A ATOH8 NAV2 MYRF	1.72e-06	181	89	6	b45b11428d13950369347e051d4d517efb2bd4fd
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DPP6 WWC2 MYO9A ATOH8 NAV2 MYRF	2.01e-06	186	89	6	3aebe163799109ffc67e4e10ee47c2dd0886a92c
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DPP6 MYO9A ATOH8 NAV2 C5 MYRF	2.08e-06	187	89	6	58d48128547ee3513d0bf7f78e61b76b1c472ca9
ToppCell	renal_medulla_nuclei-Adult_normal_reference\|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	DPP6 KANK1 PTPN14 ANK2 MTSS1 UNC13C	2.28e-06	190	89	6	f1363f7806cfc4f14fbc1b0e8dac2de813a88eee
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DPP6 KANK1 KLHL1 DOCK9 MTSS1 CSMD2	2.97e-06	199	89	6	333056c2abe9724efeab542c0365fcfe4eff8f18
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DPP6 WWC2 MYO9A ATOH8 NAV2 MYRF	2.97e-06	199	89	6	d43c605a4ff221cf78d91678c15d2ad20f831c7f
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DPP6 KANK1 DOCK9 MTSS1 CSMD2 UNC79	2.97e-06	199	89	6	19a97e27a4758e794ce7246d295e112b47931a48
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DPP6 KANK1 KLHL1 DOCK9 MTSS1 CSMD2	2.97e-06	199	89	6	e60ecbb8fa7bcd3e2ce7d78f6efb2cfd1fd77698
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DPP6 WWC2 MYO9A ATOH8 NAV2 MYRF	3.06e-06	200	89	6	8683445ad5b70748c4a1f12eb77d47623085147e
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma-3\|TCGA-Brain / Sample_Type by Project: Shred V9	EYS ZNF609 UBR4 CSMD2 ZNF804A	7.66e-06	135	89	5	3351e8b9e417397c5fa9f856184ff24ce1a27242
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-3\|TCGA-Brain / Sample_Type by Project: Shred V9	TCF12 UBR4 SIX4 CSMD2 ZNF804A	1.24e-05	149	89	5	768877bade04ca0321593b8470b5011ad8270431
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-stromal_related\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PDE4C ZNF266 GRIA3 BBS12 DMXL1	1.80e-05	161	89	5	8aaca49b53a551395f4025ac4e535c7b0ce41a49
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-stromal_related-ICC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PDE4C ZNF266 GRIA3 BBS12 DMXL1	1.80e-05	161	89	5	deb10628d258fb813c293f81fb71be8e383dc82a
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-mesothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NFE2L3 PPP2R2B TTLL6 COL6A5 MYRF	2.14e-05	167	89	5	743df5908c1ceb43b34b240d9f9649f30f4142fa
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-mesothelial_cell-mesothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NFE2L3 PPP2R2B TTLL6 COL6A5 MYRF	2.14e-05	167	89	5	1adb566f98af0109c8cc6e36033b89651e2c75e7
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NFE2L3 MYO9A GRIA3 KCNK6 KANK2	2.47e-05	172	89	5	7fb31ccbcd0204c3612986a6bc20d57ed6825e9c
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NFE2L3 MYO9A GRIA3 KCNK6 KANK2	2.47e-05	172	89	5	2a4614b3d25e8c6b095e6992d8ca35371dcdb5e1
ToppCell	Control-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DPP6 MYO9A ATOH8 NAV2 MYRF	2.83e-05	177	89	5	9af14a056eb6d88c6f11b09f6d4c0d3448d647d5
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KANK1 ADAMTS6 PCDH19 ZNF804A VWA5B1	2.99e-05	179	89	5	cd7f0e8f4abb2a2bac366c8910c8c5fda841dbce
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MEP1B KANK1 DOCK9 NAV2 MYRF	3.15e-05	181	89	5	576da14ab3107f89e1f44a4a439d1bef5bb42370
ToppCell	3'-Adult-SmallIntestine-Endothelial-blood_vessel_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HEG1 ADAMTS6 ATOH8 DOCK9 PCDH19	3.32e-05	183	89	5	858682df5592c6856487487a7baabd6e60e63a38
ToppCell	3'-Adult-SmallIntestine-Endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HEG1 ADAMTS6 ATOH8 DOCK9 PCDH19	3.32e-05	183	89	5	f8212bf8a8b8312434ae030261c558c147f61747
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DPP6 ATOH8 NAV2 C5 MYRF	3.32e-05	183	89	5	ff6dde877659cde9daa3263db0932c9c9ef1adac
ToppCell	AT1-AT2_cells-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	WWC2 HEG1 ATOH8 KANK2 MYRF	3.32e-05	183	89	5	6821dca076318115d360ff426eb1218cfe104063
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PPP4R1 WWC2 PTPN14 NAV2 MYRF	3.40e-05	184	89	5	57c792e6e2fedba25d3350ffe649fd74750b579d
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-AT2_Progenitor\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DPP6 ATOH8 NAV2 C5 MYRF	3.40e-05	184	89	5	7cc5796557379c3d1db078c1aeda40659c6e401c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DPP6 KANK1 PTPN14 MTSS1 ZNF804A	3.40e-05	184	89	5	7294b379ce4cb8fa75e432559082f93cd106aaf5
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PPP4R1 WWC2 PTPN14 NAV2 MYRF	3.40e-05	184	89	5	d7bd0f0c607bade67c99e9fb3578a570298bf926
ToppCell	Control-Epithelial_alveolar\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DPP6 ATOH8 NAV2 C5 MYRF	3.49e-05	185	89	5	3937e026add96a396122139daf8011cfbc60e75c
ToppCell	droplet-Tongue-nan-24m-Epithelial-parabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NFE2L3 PCDH19 KCNK6 VSIG8 IDE	3.59e-05	186	89	5	18c06041c6c8a0ebac17b3c8aaebd67e652d315a
ToppCell	human_hepatoblastoma-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	KANK1 ADAMTS6 ZC3H13 TOM1L1 MTSS1	3.68e-05	187	89	5	f3e37c18ac6471c7992609bbddfa4975571c815c
ToppCell	wk_15-18-Epithelial-PNS-PCP4+_neuron\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	DPP6 PPP2R2B GRIA3 PPEF1 ZNF804A	3.87e-05	189	89	5	22c927d2691b867fbdee1fbee042a6d3f7eadd7d
ToppCell	renal_medulla_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	KANK1 PTPN14 SLC12A1 MYO9A ERC1	3.87e-05	189	89	5	830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN14 SLC12A1 DCDC1 MYO9A NAV2	3.97e-05	190	89	5	3fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PPP4R1 WWC2 HEG1 NAV2 MYRF	3.97e-05	190	89	5	30b50d183d7649146eb1e79b47ba897355f1998a
ToppCell	LAM-Epithelial-AT1\|Epithelial / Condition, Lineage and Cell class	WWC2 HEG1 NAV2 KANK2 MYRF	4.07e-05	191	89	5	3457e15d1e9b36a78363d46b320c4ec46b40290a
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_GGH\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTS6 PCDH19 LAMC3 ZNF804A VWA5B1	4.07e-05	191	89	5	06760c3bb40e4f66879a5f5e09c9abfce4ebbba3
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN14 SLC12A1 DCDC1 MYO9A NAV2	4.07e-05	191	89	5	5a67ff17fb4b9eff641176dff07830c9cd73754e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN14 SLC12A1 DCDC1 MYO9A NAV2	4.07e-05	191	89	5	55ab2854a02cdcfc395e49870ccb7290b5e5471d
ToppCell	facs-Skin-Anagen-3m-Epithelial-bulge_keratinocyte\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BICD2 KANK1 TCF12 ATOH8 MTSS1	4.27e-05	193	89	5	eba3c70701b051bc1ed1f4db9270cb27a77ffc3e
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HEG1 KIAA0825 ADAMTS6 ERC1 DOCK9	4.38e-05	194	89	5	0b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	KANK1 PTPN14 SLC12A1 MYO9A TOM1L1	4.49e-05	195	89	5	6477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KANK1 SLC12A1 ANK2 MYO9A TOM1L1	4.60e-05	196	89	5	eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCell	Control_saline-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control_saline / Treatment groups by lineage, cell group, cell type	EPHB3 DPP6 WWC2 ATOH8 NAV2	4.83e-05	198	89	5	85f424cd9bb3117c9e322031024aabb87696ce47
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	EPHB3 DPP6 WWC2 ATOH8 NAV2	4.83e-05	198	89	5	b598ab958e31f1e98bd06dc0097b58ac3a3f90a3
ToppCell	wk_08-11-Epithelial-PNS-TM4SF4+_CHODL+_neuron\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	DPP6 PPP2R2B ANK2 GPC2 ZNF804A	4.83e-05	198	89	5	eb3c389e7452d74e5e15179503e480d6d11ca9ca
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	EPHB3 DPP6 WWC2 ATOH8 NAV2	4.94e-05	199	89	5	a270630626df614f8605abddb7dee7c4d74f6149
ToppCell	Tracheal-NucSeq-Stromal-Peri/Epineurial_-NAF_epineurial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ANK2 PCDH19 AGMO MTSS1 KANK2	4.94e-05	199	89	5	9c2db0bb94cba71a3cc1827844da090e213e0258
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DPP6 WWC2 MYO9A ATOH8 NAV2	5.06e-05	200	89	5	ddfb1f006365bf16203ee49f20200f68220cc288
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-GGH-L1-3\|Neuronal / cells hierarchy compared to all cells using T-Statistic	KANK1 ADAMTS6 PCDH19 LAMC3 ZNF804A	5.06e-05	200	89	5	48303e499251d6754cfa991dc2d96c5563b2123c
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-GGH\|Neuronal / cells hierarchy compared to all cells using T-Statistic	KANK1 ADAMTS6 PCDH19 LAMC3 ZNF804A	5.06e-05	200	89	5	4802dd6cae84b41746227a5d1aa1c9b858495e36
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DPP6 ATOH8 C5 MYRF	1.34e-04	130	89	4	6434d9106ccb38786dad36fab80163dfc07b6eb7
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PPP2R2B PTPN14 MYO9A UNC13C	1.47e-04	133	89	4	f303ab771482281d8793974f9f5279cee09431fe
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligodendroglioma-3\|TCGA-Brain / Sample_Type by Project: Shred V9	EYS ZNF609 TCF12 ZNF804A	1.55e-04	135	89	4	b128596653a5e3b64ed7f657bbfeda35438e2e48
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	EYS KLHL1 UNC13C CSMD2	2.21e-04	148	89	4	d6ac5972267254651dfbe16bb4e9a62228093cc7
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HEG1 ADAMTS6 RBM46 ZMYM1	2.33e-04	150	89	4	322aa0c3fc159a4b2897daac881dfc744b24ffc4
ToppCell	LPS_only-Lymphocytic_NKT-iNKT/MAIT-T-cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNHD1 PPP2R2B EP400 VSIG8	2.39e-04	151	89	4	7270b8bbfae659e110bd9d513b602120b25de3dd
ToppCell	droplet-Liver-Npc-21m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPP2R2B ADAMTS6 DLG4 LAMC3	2.57e-04	154	89	4	d883b3e2a65e4375bea1216eb9bbc86c64ee449c
ToppCell	droplet-Liver-Npc-21m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPP2R2B MYO9A DLG4 LAMC3	2.63e-04	155	89	4	5d600e159738231d0607ea1a1ebd8510fc241b36
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A5 KCNK6 ZNF804A VWA5B1	2.63e-04	155	89	4	8fdda4e3657ac56188ae88ed3caf145f4d9d1567
ToppCell	356C-Myeloid-Dendritic-pDC\|356C / Donor, Lineage, Cell class and subclass (all cells)	THADA GRIA3 GPC2 DMXL1	2.70e-04	156	89	4	d9d87368e43b24952e70f31f38425e15b716ff5b
ToppCell	severe_influenza-CD8+_T_naive\|World / disease group, cell group and cell class (v2)	ZNF266 ADAMTS6 SCML1 DLG3	2.97e-04	160	89	4	a1181ef36b453eba53b04d836aa9f65a71354cdb
ToppCell	356C-Fibroblasts-Fibroblast-G-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	DPP6 MTSS1 COL6A5 VSIG8	2.97e-04	160	89	4	0293b244c063a62819690bf22bbc2681f8d15252
ToppCell	356C-Fibroblasts-Fibroblast-G\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	DPP6 MTSS1 COL6A5 VSIG8	2.97e-04	160	89	4	3eaae86fa08f7651021316f8e5811bf48055591e
ToppCell	normal_Lung-Myeloid_cells-Undetermined\|Myeloid_cells / Location, Cell class and cell subclass	DOCK9 TOM1L1 VSIG8 C5	3.04e-04	161	89	4	283012858e575c70d09950de53da041509f59bfa
ToppCell	severe_influenza-CD8+_T_naive\|severe_influenza / disease group, cell group and cell class (v2)	ZNF266 ADAMTS6 SCML1 DLG3	3.04e-04	161	89	4	82196139cdbbd70a36957a87bc9ac6d02575da3f
ToppCell	E16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNHD1 DNAJB7 VSIG8 PADI3	3.12e-04	162	89	4	8e0f03fcc25b2ea777e8478fbf771699cf93719c
ToppCell	E16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNHD1 DNAJB7 VSIG8 PADI3	3.12e-04	162	89	4	e0417f1242edf71934fe62bccc55c4678f7ff4ac
ToppCell	P15-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	NFE2L3 KANK1 UNC13C MYRF	3.42e-04	166	89	4	545f6c91102568791443717e522f89cb3bd1a070
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HEG1 ADAMTS6 DNAJB7 CRYBG3	3.42e-04	166	89	4	8e5f2afbeffae5e77fcb29e8fe9f5aa49779b619
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	GRIA3 SIX4 ZNF804A UNC79	3.50e-04	167	89	4	9efb9511a211d0824bb97f82c1a5860c43d2138f
ToppCell	Cerebellum-Neuronal-Inhibitory\|Cerebellum / BrainAtlas - Mouse McCarroll V32	GRIA3 SIX4 ZNF804A UNC79	3.50e-04	167	89	4	904c613aac3f9919a432b110bb1dcc832b5aec0a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HEG1 PDE8B DOCK9 MTSS1	3.66e-04	169	89	4	987ff79ad563825dd9877ea8ccb536758f8c6700
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNHD1 PDE8B DOCK9 CRYBG3	3.66e-04	169	89	4	8a6d05b5d60b2b2e43a8ff7521feb79cd6dbd940
ToppCell	Control-Epithelial_cells-ECM-high_epithelial\|Control / group, cell type (main and fine annotations)	WWC2 HEG1 PTPN14 NAV2	3.74e-04	170	89	4	e2023d66e70983c87dacbd6181d3426488d1fc57
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KLHL1 NAV2 PADI3 FANCA	3.82e-04	171	89	4	c2dbc439af28d4fabb24d57685b75b2e588819b0
ToppCell	droplet-Pancreas-Exocrine\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPN14 AGMO LAMC3 MYRF	3.82e-04	171	89	4	92ac4cc3d54da2ea8e202aa59c78e8875356649e
ToppCell	COVID-19-Heart-T_cell\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PPP2R2B EYS KLHL1 UNC13C	3.82e-04	171	89	4	b2e753e811a7639956994609f73efcdb62d04f82
ToppCell	E12.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	KIAA0825 DOCK9 ZNF407 IDE	3.91e-04	172	89	4	3b9be685fcd1634498a603b692f5ac6ddd0de176
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NFE2L3 PPP2R2B UNC13C MYRF	4.00e-04	173	89	4	ee7d1429f23f1b89a9a9f7bc07a84a44cf7acd1c
ToppCell	AT1_cells-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	WWC2 HEG1 NAV2 MYRF	4.00e-04	173	89	4	3afca2a429c634af0220c1aa19ce4cf4ee3e8b3e
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NFE2L3 PPP2R2B UNC13C MYRF	4.00e-04	173	89	4	3725525b99a6011eda2ff5459b4fd2e1eab1f090
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PPP2R2B DCDC1 LINC00052 DNAJB7	4.00e-04	173	89	4	922356a5b4c84607318ac24d7caa2e235b72b066
ToppCell	facs-Lung-24m-Mesenchymal-myofibroblast-myofibroblast_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KANK1 CALHM5 DLG3 BBS12	4.08e-04	174	89	4	eb8012823b08729b462d1e5212f4873bb6b4eb1e
ToppCell	Control-Epithelial_cells-AT1\|Control / group, cell type (main and fine annotations)	WWC2 PTPN14 NAV2 MYRF	4.08e-04	174	89	4	548d7f2b958a2bfd2c95eb049ceaab55a559c77d
ToppCell	facs-Lung-24m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KANK1 CALHM5 DLG3 BBS12	4.08e-04	174	89	4	32fdeeebeeeca657eac6329caad4c28ca54e4d1c
ToppCell	PND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DPP6 SIX4 CSMD2 VWA5B1	4.17e-04	175	89	4	8362a46f5804333baa84cd56d450bc147f372a7e
ToppCell	TCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Non-keratinizing_Cervical_Squamous_Cell_Carcinoma-3\|TCGA-Cervix / Sample_Type by Project: Shred V9	PPP2R2A MTSS1 CRYBG3 PADI3	4.17e-04	175	89	4	0cc215109d9915af47e4d0a120ce2e46910715fa
ToppCell	PND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DPP6 SIX4 CSMD2 VWA5B1	4.17e-04	175	89	4	8b4c62e608f0ec84e563bbf0ebffe3ed44085298
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTS6 LAMC3 ZNF804A VWA5B1	4.17e-04	175	89	4	9d09636a103daa8f622c3dbfd1f1536aaec3b6bb
ToppCell	3'-GW_trimst-2-SmallIntestine-Neuronal-neurons_B-Branch_B3_(IPAN)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DPP6 PPP2R2B SLC12A1 ZNF804A	4.26e-04	176	89	4	04dad262929581872e5bbc66cd8182c963e7e52f
ToppCell	3'-Adult-Appendix-Epithelial-mature_enterocytic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PCYOX1L KANK1 C5 UNC79	4.26e-04	176	89	4	30adf8f1638c6244586f8101c2590bb964dfae00
ToppCell	3'-Adult-Appendix-Epithelial-mature_enterocytic-Colonocyte\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PCYOX1L KANK1 C5 UNC79	4.26e-04	176	89	4	23fa02d4c39e0b8faa1658116d50b6233a952ccc
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN14 MYO9A ATOH8 MTSS1	4.26e-04	176	89	4	327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCell	facs-Lung-nan-3m-Epithelial-club_cell_of_bronchiole\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPP2R2B TOM1L1 DLG3 SIX4	4.36e-04	177	89	4	e5070934c674a46e070b0d52b9a374516bf6aea1
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN14 MYO9A ATOH8 MTSS1	4.36e-04	177	89	4	da8802a6351d3e510822f82e2fde8a4314a2216e
ToppCell	facs-Lung-nan-3m-Epithelial-Club_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPP2R2B TOM1L1 DLG3 SIX4	4.36e-04	177	89	4	b37d821f4f3204daf7c568ac17a0af0ba97273d6
Disease	level of Phosphatidylcholine (18:2_20:4) in blood serum	DPP6 MYRF	1.67e-04	7	84	2	OBA_2045109
Disease	benign neoplasm (implicated_via_orthology)	DLG3 DLG4	2.22e-04	8	84	2	DOID:0060072 (implicated_via_orthology)
Disease	primary ovarian insufficiency	ZNF485 RBM46	2.85e-04	9	84	2	EFO_0004266
Disease	non-syndromic X-linked intellectual disability (implicated_via_orthology)	THADA DLG3	2.85e-04	9	84	2	DOID:0050776 (implicated_via_orthology)
Disease	cytokine measurement	EPHB3 PPP2R2B DCDC1 ANK2 UNC13C ZNF804A FANCA	3.49e-04	461	84	7	EFO_0004873
Disease	developmental disorder of mental health (implicated_via_orthology)	TCF12 DLG3 DLG4	3.73e-04	49	84	3	DOID:0060037 (implicated_via_orthology)
Disease	autosomal dominant cerebellar ataxia (implicated_via_orthology)	PPP2R2A PPP2R2B	5.19e-04	12	84	2	DOID:1441 (implicated_via_orthology)
Disease	stenosing tenosynovitis	KLHL1 ADAMTS6	5.19e-04	12	84	2	EFO_0010822
Disease	low density lipoprotein cholesterol measurement, response to selective serotonin reuptake inhibitor	ADAMTS6 CSMD2	8.21e-04	15	84	2	EFO_0004611, EFO_0005658
Disease	phosphatidylcholine 38:3 measurement	DPP6 MYRF	9.36e-04	16	84	2	EFO_0010385
Disease	nucleotide measurement	DPP6 RBM46 UNC13C	1.20e-03	73	84	3	EFO_0010513
Disease	Arthrogryposis	BICD2 MYO9A	1.62e-03	21	84	2	C0003886
Disease	response to xenobiotic stimulus	THADA KLHL1 UBR4 CSMD2	1.84e-03	182	84	4	GO_0009410
Disease	Autism Spectrum Disorders	DPP6 DLG4 LAMC3	1.86e-03	85	84	3	C1510586
Disease	thalamus volume	DPP6 DCDC1 NAV2	1.86e-03	85	84	3	EFO_0006935
Disease	alpha-linolenic acid measurement	KIAA0825 MYRF	2.30e-03	25	84	2	EFO_0007759
Disease	Bipolar Disorder	DOCK9 GRIA3 DLG3 DLG4 ZNF804A FBXL3	2.43e-03	477	84	6	C0005586
Disease	cholesteryl ester measurement, intermediate density lipoprotein measurement	NFE2L3 DLG4 KANK2	2.48e-03	94	84	3	EFO_0008595, EFO_0010351

Protein segments in the cluster

Peptide	Gene	Start	Entry
QDENATHTQLYTSHF	EP400	2451	Q96L91
AHTYHINSISVNSDY	PPP2R2B	171	Q00005
SINDSFYTSHLHVSL	BICD2	266	Q8TD16
SHETTVYFHSDHSQN	CSMD2	2051	Q7Z408
AYHQYLQTSQSHSSE	CRYBG3	2236	Q68DQ2
HTYHINSISINSDYE	PPP2R2A	176	P63151
QTHHSSEDYNLSTAL	AGMO	146	Q6ZNB7
FLYQVSSHEQSESTH	FLG	1441	P20930
HEQAQDSSRHSASQY	FLG	3091	P20930
FLYQVSTHEQSESAH	FLG	3386	P20930
FQNTVSDLSELHHAY	DNHD1	981	Q96M86
LSSNLQHHFSLSSVY	ANGEL2	441	Q5VTE6
SEFEASTYIQHHLQN	BBS12	611	Q6ZW61
SASEFASHHYNLNIL	CBLL2	351	Q8N7E2
ASDFHLQEHSNSNSY	DMXL1	2471	Q9Y485
FHSDHRLSYSSQEEF	ADAMTS6	21	Q9UKP5
DFQKILDTYSQHHTS	ALPK1	451	Q96QP1
NYEDDHFKSSHSNQT	ERC1	986	Q8IUD2
HLDYNFHRSSINSLS	RBM46	466	Q8TBY0
TSEELHYFVQNHFTS	UQCRC2	201	P22695
SHQQLSASSHTDYAS	KCNK6	296	Q9Y257
TDANHTTSFHSSEVY	ANK2	2946	Q01484
ADLDYSADHSNLSFS	ATOH8	286	Q96SQ7
RNTSANHIYHHSFNS	PCDH19	841	Q8TAB3
FHTLTSEYNHLDSDF	GDAP2	391	Q9NXN4
HSHDEISDLDSYKSN	DCDC1	106	M0R2J8
SDQVLHSKQSHFYET	EYS	1571	Q5T1H1
EYSHNSFDLHCLLNS	KIAA0825	6	Q8IV33
SVAQHSLTQLFSHSY	GPC2	116	Q8N158
LNYHVDHLDSSNSFS	GRIA3	71	P42263
SVNKQHYESGAASFH	PCYOX1L	71	Q8NBM8
LSNGFSHYSLSSESH	MTSS1	346	O43312
AYHNSLHAADVAQST	PDE4C	386	Q08493
SNAYHNSTHAADVLH	PDE8B	611	O95263
NSSAHYHVNFSQAIS	NFE2L3	296	Q9Y4A8
FTDSPHYSDHLNDSR	TCF12	76	Q99081
NGNTALHYSVSHSNF	KANK1	1161	Q14678
HNNFYRADSDSADSA	EPHB3	321	P54753
SNSSHSEYSSFFHAQ	HEG1	591	Q9ULI3
DLNDSHVQISYHSSH	PADI3	86	Q9ULW8
SHSSKHVSQYTFVDN	DNAJB7	251	Q7Z6W7
NSLTFNHSYGHSDAD	DOCK9	1371	Q9BZ29
HSNHLQYVSFKVDSS	FBXL3	106	Q9UKT7
SELHSFHQSQQHYST	CALHM5	266	Q8N5C1
FHQSSRSYDHSENSD	FANCA	991	O15360
LAQYSDEFHSEFHLS	COL6A5	71	A8TX70
YSSGHVHLSSENKFQ	C5	66	P01031
YASTFTALADNHISH	DLG3	326	Q92796
TTSYSQHLDNEISHS	DLG4	261	P78352
NGNTALHYSVSHANF	KANK2	666	Q63ZY3
EYSQFLSEHAGSSNA	IDE	126	P14735
DESHYFTSSSLKQHL	DPP6	821	P42658
HNFNTYSDDISDSLN	MEP1B	186	Q16820
KLFSSHYNVHIDDSQ	PPEF1	596	O14829
ADSIHNTYSTDHASA	SCML1	216	Q9UN30
AYSDSKHGTNSDFQH	THADA	1416	Q6YHU6
LTSSHAYDNFLEHSN	TOM1L1	386	O75674
STLHYIHSDSDLSNN	PPP4R1	586	Q8TF05
YDSDSNSNSHHDDIL	NAV2	2466	Q8IVL1
EHYSETHTSQDSIFH	PTPN14	346	Q15678
YSILESHSFESANHP	SIX4	166	Q9UIU6
AYNSFLNHSDSESDV	SHOC1	1216	Q5VXU9
KTDASFHAYDSHTNT	SLC12A1	81	Q13621
SSALSNSFHHLQLFD	TBC1D17	191	Q9HA65
AFSDLSSFQNHETTH	ZNF823	451	P16415
TSQHSYHSELSYQES	VSIG8	196	P0DPA2
SSSHDASLHQFTADF	WWC2	571	Q6AWC2
HFTLNYTSHAHELSA	LINC00052	101	Q96N35
SHYSDSQLSLHEDLS	UNC13C	641	Q8NB66
SAHYSYDHQTEELNL	PRPH2	231	P23942
SDQSYHTHLLSTNTA	ZNF609	986	O15014
DKNSFFHYDSHSRSN	SENP8	111	Q96LD8
FNSYAHLSHSQDIKS	TCF20	1296	Q9UGU0
YSINKHSSNFSRDAH	TTLL6	266	Q8N841
SICSNNFDSFLHETH	ZC3HAV1	796	Q7Z2W4
HSSNTSFADELSHLL	ZMYM1	836	Q5SVZ6
KSFYTESNLHQHLAS	ZNF407	1451	Q9C0G0
ENYLQTSSLLASDHH	TRAPPC10	536	P48553
SSDEEFAAALYHFNH	UBR4	701	Q5T4S7
AFSYCSSLSQHQKSH	ZNF79	201	Q15937
YNSSFISHQRNHTSE	ZNF485	141	Q8NCK3
SQIDSHSSNSNYHDS	ZC3H13	581	Q5T200
HSQESGSSVFYHSQD	VWA5B1	596	Q5TIE3
SSSHHSLDNADFDNK	UNC79	476	Q9P2D8
SHSYSSDESLNRQNH	ZNF804A	776	Q7Z570
FSYSNSFQLHERTHT	ZNF266	501	Q14584
DSSSSEEFYQAVHHA	KLHL1	181	Q9NR64
HNASYLTDFHSQDES	LAMC3	86	Q9Y6N6
LKSTTESYVFHNHSN	N4BP2L2	26	Q92802
HFRPTQSYSHNSDDL	MYO9A	1646	B2RTY4
SSEALAQPATDYHFH	MYRF	1131	Q9Y2G1