Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	gap junction channel activity	GJB2 GJB3 GJB6	1.20e-05	25	36	3	GO:0005243
GeneOntologyMolecularFunction	integrin binding	LAMB1 FBN1 ADAM11 ITGB6 SVEP1	1.48e-05	175	36	5	GO:0005178
GeneOntologyMolecularFunction	extracellular matrix structural constituent	LAMA3 LAMB1 LTBP2 FBN1 HMCN1	2.09e-05	188	36	5	GO:0005201
GeneOntologyMolecularFunction	wide pore channel activity	GJB2 GJB3 GJB6	4.01e-05	37	36	3	GO:0022829
GeneOntologyMolecularFunction	calcium ion binding	CD93 GJB2 LTBP2 LTBP3 FBN1 HMCN1 LRP1B SVEP1	4.49e-05	749	36	8	GO:0005509
GeneOntologyMolecularFunction	gap junction channel activity involved in cell communication by electrical coupling	GJB2 GJB6	1.13e-04	9	36	2	GO:1903763
GeneOntologyMolecularFunction	transforming growth factor beta binding	CHRDL1 LTBP3	9.99e-04	26	36	2	GO:0050431
GeneOntologyMolecularFunction	growth factor binding	CHRDL1 LTBP2 LTBP3	2.76e-03	156	36	3	GO:0019838
GeneOntologyMolecularFunction	cytokine binding	CHRDL1 LTBP3 TNFRSF1A	2.81e-03	157	36	3	GO:0019955
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	GATA3 GLIS3 ZNF57 ZNF143 ZSCAN25 GLIS1 ZNF426 EPAS1	3.11e-03	1412	36	8	GO:0000981
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	GATA3 GLIS3 ZNF143 GLIS1 EPAS1	3.13e-03	560	36	5	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	GATA3 GLIS3 ZNF143 GLIS1 EPAS1	3.28e-03	566	36	5	GO:0001216
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	GATA3 GLIS3 ZNF57 ZNF143 ZSCAN25 GLIS1 ZNF426 EPAS1	3.81e-03	1459	36	8	GO:0000977
GeneOntologyMolecularFunction	cell adhesion molecule binding	LAMB1 FBN1 ADAM11 ITGB6 SVEP1	4.17e-03	599	36	5	GO:0050839
GeneOntologyMolecularFunction	transcription coactivator binding	GATA3 EPAS1	4.26e-03	54	36	2	GO:0001223
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	GATA3 GLIS3 ZNF143 ZSCAN25 GLIS1 ZNF426 EPAS1	6.08e-03	1244	36	7	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	GATA3 GLIS3 ZNF143 ZSCAN25 GLIS1 ZNF426 EPAS1	6.82e-03	1271	36	7	GO:0000987
GeneOntologyCellularComponent	extracellular matrix	LAMA3 LAMB1 INHBE LTBP2 LTBP3 FBN1 ADAM11 ZAN HMCN1 SVEP1	1.85e-07	656	38	10	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	LAMA3 LAMB1 INHBE LTBP2 LTBP3 FBN1 ADAM11 ZAN HMCN1 SVEP1	1.90e-07	658	38	10	GO:0030312
GeneOntologyCellularComponent	collagen-containing extracellular matrix	LAMA3 LAMB1 INHBE LTBP2 LTBP3 FBN1 ADAM11 HMCN1	4.05e-06	530	38	8	GO:0062023
GeneOntologyCellularComponent	connexin complex	GJB2 GJB3 GJB6	8.33e-06	22	38	3	GO:0005922
GeneOntologyCellularComponent	gap junction	GJB2 GJB3 GJB6	4.13e-05	37	38	3	GO:0005921
GeneOntologyCellularComponent	basement membrane	LAMA3 LAMB1 FBN1 HMCN1	6.99e-05	122	38	4	GO:0005604
GeneOntologyCellularComponent	laminin complex	LAMA3 LAMB1	1.43e-04	10	38	2	GO:0043256
GeneOntologyCellularComponent	cell-cell junction	LAMA3 GJB2 GJB3 HMCN1 GJB6	4.12e-03	591	38	5	GO:0005911
GeneOntologyCellularComponent	protein complex involved in cell adhesion	LAMB1 ITGB6	5.16e-03	59	38	2	GO:0098636
GeneOntologyCellularComponent	anchoring junction	LAMA3 GJB2 GJB3 HMCN1 ITGB6 GJB6	7.83e-03	976	38	6	GO:0070161
HumanPheno	Iridodonesis	CHRDL1 LTBP2 FBN1	3.69e-07	5	18	3	HP:0100693
HumanPheno	Equinus calcaneus	GJB2 FBN1 GJB6	2.05e-06	8	18	3	HP:0008138
HumanPheno	Deep anterior chamber	CHRDL1 LTBP2	1.18e-05	2	18	2	HP:0007765
HumanPheno	Fifth metacarpal with ulnar notch	LTBP3 FBN1	1.18e-05	2	18	2	HP:0005900
HumanPheno	Digenic inheritance	GJB2 GJB3 GJB6	2.02e-05	16	18	3	HP:0010984
HumanPheno	Scarring alopecia of scalp	LAMA3 GJB2 GJB6	2.02e-05	16	18	3	HP:0004552
HumanPheno	Lip fissure	GJB2 GJB6	3.53e-05	3	18	2	HP:0031250
HumanPheno	Thickened skin	LAMA3 GJB2 GJB3 LTBP2 LTBP3 FBN1 ITGB6 GJB6	5.04e-05	431	18	8	HP:0001072
HumanPheno	Microspherophakia	LTBP2 FBN1	7.05e-05	4	18	2	HP:0030961
HumanPheno	Cobblestone-like hyperkeratosis	GJB2 GJB6	7.05e-05	4	18	2	HP:0031288
HumanPheno	Dilatated internal auditory canal	GJB2 GJB6	1.17e-04	5	18	2	HP:0004458
HumanPheno	Hair follicle neoplasm	GJB2 GJB6	1.17e-04	5	18	2	HP:0012843
HumanPheno	Trichilemmoma	GJB2 GJB6	1.17e-04	5	18	2	HP:0012844
HumanPheno	Spherophakia	LTBP2 FBN1	1.17e-04	5	18	2	HP:0034375
HumanPheno	Progeroid facial appearance	GJB2 FBN1 GJB6	1.42e-04	30	18	3	HP:0005328
HumanPheno	Punctate keratitis	GJB2 GJB6	1.75e-04	6	18	2	HP:0011859
HumanPheno	Psoriasiform dermatitis	GATA3 GJB2 GJB6	1.89e-04	33	18	3	HP:0003765
HumanPheno	Amelogenesis imperfecta	LAMA3 LTBP3 ITGB6	1.89e-04	33	18	3	HP:0000705
HumanPheno	Delayed pubic bone ossification	GJB2 GJB6	2.45e-04	7	18	2	HP:0008788
HumanPheno	Posterior blepharitis	GJB2 GJB6	2.45e-04	7	18	2	HP:0025610
HumanPheno	Abnormal conjunctiva morphology	LAMA3 GJB2 FBN1 TNFRSF1A GJB6	2.76e-04	176	18	5	HP:0000502
HumanPheno	Abnormal intraocular pressure	GLIS3 CHRDL1 LTBP2	3.13e-04	39	18	3	HP:0012632
HumanPheno	Stapes ankylosis	GJB2 GJB6	3.26e-04	8	18	2	HP:0000381
HumanPheno	Limbal stem cell deficiency	GJB2 GJB6	3.26e-04	8	18	2	HP:0032107
HumanPheno	Recurrent bacterial skin infections	LAMA3 GJB2 GJB6	3.90e-04	42	18	3	HP:0005406
HumanPheno	Absent pubic hair	GJB2 GJB6	4.18e-04	9	18	2	HP:0002555
HumanPheno	Folliculitis	GJB2 GJB6	4.18e-04	9	18	2	HP:0025084
HumanPheno	Lens dislocation	CHRDL1 LTBP2 FBN1	4.19e-04	43	18	3	HP:0000665
HumanPheno	Ectopia lentis	CHRDL1 LTBP2 FBN1	4.19e-04	43	18	3	HP:0001083
HumanPheno	Alopecia of scalp	LAMA3 GJB2 GJB6	4.79e-04	45	18	3	HP:0002293
HumanPheno	Abnormally large globe	GLIS3 LTBP2 FBN1	4.79e-04	45	18	3	HP:0001090
HumanPheno	Abnormality of skin physiology	GATA3 SCNN1G LAMA3 GJB2 GJB3 TNFRSF1A EPAS1 GJB6	4.85e-04	593	18	8	HP:0011122
HumanPheno	Abnormal ossification of the pubic bone	GJB2 GJB6	5.22e-04	10	18	2	HP:0009105
HumanPheno	Skin plaque	LAMA3 GJB2 GJB6	5.45e-04	47	18	3	HP:0200035
HumanPheno	Keratoconjunctivitis sicca	GJB2 FBN1 GJB6	5.45e-04	47	18	3	HP:0001097
HumanPheno	Palmoplantar keratoderma	LAMA3 GJB2 GJB3 GJB6	5.71e-04	114	18	4	HP:0000982
HumanPheno	Conjunctivitis	GJB2 FBN1 TNFRSF1A GJB6	5.91e-04	115	18	4	HP:0000509
HumanPheno	Aplastic/hypoplastic lacrimal glands	GJB2 GJB6	6.37e-04	11	18	2	HP:0008038
HumanPheno	Abnormal vestibular function	GJB2 GJB3 TNFRSF1A EPAS1 GJB6	6.54e-04	212	18	5	HP:0001751
HumanPheno	Red eye	GJB2 FBN1 TNFRSF1A GJB6	6.94e-04	120	18	4	HP:0025337
HumanPheno	Keratoconjunctivitis	GJB2 FBN1 GJB6	7.35e-04	52	18	3	HP:0001096
HumanPheno	Angular cheilitis	GJB2 GJB6	7.62e-04	12	18	2	HP:0030318
HumanPheno	Megalocornea	CHRDL1 LTBP2 FBN1	8.21e-04	54	18	3	HP:0000485
HumanPheno	Epidermal acanthosis	GJB2 GJB3 GJB6	8.21e-04	54	18	3	HP:0025092
HumanPheno	Anterior chamber mesodermal anomalies	CHRDL1 LTBP2 FBN1	8.21e-04	54	18	3	HP:0008040
HumanPheno	Severe sensorineural hearing impairment	GJB2 GJB6	8.99e-04	13	18	2	HP:0008625
HumanPheno	Prelingual sensorineural hearing impairment	GJB2 GJB6	8.99e-04	13	18	2	HP:0000399
HumanPheno	Abnormal lacrimal gland morphology	GJB2 GJB6	8.99e-04	13	18	2	HP:0011482
HumanPheno	Absent axillary hair	GJB2 GJB6	8.99e-04	13	18	2	HP:0002221
HumanPheno	Hyperkeratotic papule	GJB2 GJB6	8.99e-04	13	18	2	HP:0045059
HumanPheno	Acne inversa	GJB2 GJB6	8.99e-04	13	18	2	HP:0040154
HumanPheno	Palmoplantar hyperkeratosis	LAMA3 GJB2 GJB3 GJB6	9.12e-04	129	18	4	HP:0000972
HumanPheno	Progressive sensorineural hearing impairment	GATA3 GJB2 GJB6	9.62e-04	57	18	3	HP:0000408
HumanPheno	Abnormality of the calcaneus	GJB2 FBN1 GJB6	9.62e-04	57	18	3	HP:0008364
HumanPheno	Palmar hyperkeratosis	LAMA3 GJB2 GJB3 GJB6	9.66e-04	131	18	4	HP:0010765
HumanPheno	Plantar hyperkeratosis	LAMA3 GJB2 GJB3 GJB6	9.94e-04	132	18	4	HP:0007556
HumanPheno	Severe hearing impairment	GJB2 GJB6	1.05e-03	14	18	2	HP:0012714
HumanPheno	Chest pain	SCNN1G FBN1 TNFRSF1A EPAS1	1.14e-03	137	18	4	HP:0100749
HumanPheno	Patellar hypoplasia	GJB2 GJB6	1.21e-03	15	18	2	HP:0003065
HumanPheno	Aplasia/Hypoplasia of the lens	LTBP2 FBN1	1.21e-03	15	18	2	HP:0008063
HumanPheno	Abnormal palm morphology	ZNF462 LAMA3 GJB2 GJB3 LTBP3 FBN1 GJB6	1.31e-03	521	18	7	HP:0100871
HumanPheno	Inflammatory abnormality of the skin	GATA3 SCNN1G LAMA3 GJB2 GJB3 TNFRSF1A GJB6	1.31e-03	521	18	7	HP:0011123
HumanPheno	Progressive hearing impairment	GATA3 GJB2 GJB6	1.35e-03	64	18	3	HP:0001730
HumanPheno	Abnormal stapes morphology	GJB2 GJB6	1.55e-03	17	18	2	HP:0008628
HumanPheno	Abnormal pelvis bone ossification	GJB2 GJB6	1.55e-03	17	18	2	HP:0009106
HumanPheno	Recurrent candida infections	GJB2 GJB6	1.55e-03	17	18	2	HP:0005401
HumanPheno	Knee pain	GJB2 GJB6	1.55e-03	17	18	2	HP:0030839
HumanPheno	Alopecia	LAMA3 GJB2 GJB3 ITGB6 GJB6	1.68e-03	261	18	5	HP:0001596
HumanPheno	Skin appendage neoplasm	GJB2 GJB6	1.75e-03	18	18	2	HP:0012842
HumanPheno	Abnormality of lens shape	LTBP2 FBN1	1.75e-03	18	18	2	HP:0011526
HumanPheno	Shallow anterior chamber	LTBP2 FBN1	1.75e-03	18	18	2	HP:0000594
HumanPheno	Squamous cell carcinoma	LAMA3 GJB2 GJB6	1.82e-03	71	18	3	HP:0002860
HumanPheno	Hoarse voice	LAMA3 LTBP3 FBN1 EPAS1	1.99e-03	159	18	4	HP:0001609
HumanPheno	Atypical scarring of skin	LAMA3 GJB2 GJB6	2.05e-03	74	18	3	HP:0000987
HumanPheno	Increased inflammatory response	GATA3 GLIS3 SCNN1G LAMA3 FNIP1 GJB2 GJB3 LTBP3 FBN1 TNFRSF1A GJB6	2.12e-03	1355	18	11	HP:0012649
HumanPheno	Abnormal inflammatory response	GATA3 GLIS3 SCNN1G LAMA3 FNIP1 GJB2 GJB3 LTBP3 FBN1 TNFRSF1A GJB6	2.12e-03	1355	18	11	HP:0012647
HumanPheno	Childhood onset sensorineural hearing impairment	GJB2 GJB6	2.16e-03	20	18	2	HP:0011474
MousePheno	abnormal respiratory mechanics	LAMA3 FNIP1 FBN1 TNFRSF1A ITGB6	1.27e-05	135	32	5	MP:0002314
MousePheno	decreased lung tissue damping	FNIP1 ITGB6	1.52e-05	3	32	2	MP:0011048
MousePheno	increased lung compliance	FNIP1 FBN1 ITGB6	2.73e-05	26	32	3	MP:0010895
MousePheno	abnormal lung compliance	FNIP1 FBN1 ITGB6	1.18e-04	42	32	3	MP:0002333
Domain	EGF_2	NTN5 LAMA3 CD93 LAMB1 LTBP2 LTBP3 FBN1 ADAM11 ZAN HMCN1 LRP1B ITGB6 SVEP1	1.85e-15	265	37	13	PS01186
Domain	EGF_1	NTN5 LAMA3 LAMB1 LTBP2 LTBP3 FBN1 ADAM11 ZAN HMCN1 LRP1B ITGB6 SVEP1	4.43e-14	255	37	12	PS00022
Domain	EGF-like_CS	LAMA3 CD93 LAMB1 LTBP2 LTBP3 FBN1 ADAM11 ZAN HMCN1 LRP1B ITGB6 SVEP1	5.85e-14	261	37	12	IPR013032
Domain	EGF	LAMA3 CD93 LAMB1 LTBP2 LTBP3 FBN1 ADAM11 ZAN HMCN1 LRP1B SVEP1	6.35e-13	235	37	11	SM00181
Domain	EGF-like_dom	LAMA3 CD93 LAMB1 LTBP2 LTBP3 FBN1 ADAM11 ZAN HMCN1 LRP1B SVEP1	1.19e-12	249	37	11	IPR000742
Domain	Growth_fac_rcpt_	LAMA3 CD93 LAMB1 LTBP2 LTBP3 FBN1 HMCN1 LRP1B SVEP1	1.60e-11	156	37	9	IPR009030
Domain	EGF_CA	CD93 LTBP2 LTBP3 FBN1 HMCN1 LRP1B SVEP1	3.15e-10	86	37	7	PF07645
Domain	EGF_3	CD93 LTBP2 LTBP3 FBN1 ADAM11 ZAN HMCN1 LRP1B SVEP1	6.21e-10	235	37	9	PS50026
Domain	EGF_Ca-bd_CS	CD93 LTBP2 LTBP3 FBN1 HMCN1 LRP1B SVEP1	7.42e-10	97	37	7	IPR018097
Domain	EGF_CA	CD93 LTBP2 LTBP3 FBN1 HMCN1 LRP1B SVEP1	8.57e-10	99	37	7	PS01187
Domain	ASX_HYDROXYL	CD93 LTBP2 LTBP3 FBN1 HMCN1 LRP1B SVEP1	9.20e-10	100	37	7	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	CD93 LTBP2 LTBP3 FBN1 HMCN1 LRP1B SVEP1	1.39e-09	106	37	7	IPR000152
Domain	cEGF	CD93 LTBP3 FBN1 HMCN1 LRP1B	1.47e-09	26	37	5	IPR026823
Domain	cEGF	CD93 LTBP3 FBN1 HMCN1 LRP1B	1.47e-09	26	37	5	PF12662
Domain	EGF_CA	CD93 LTBP2 LTBP3 FBN1 HMCN1 LRP1B SVEP1	3.73e-09	122	37	7	SM00179
Domain	EGF-like_Ca-bd_dom	CD93 LTBP2 LTBP3 FBN1 HMCN1 LRP1B SVEP1	4.18e-09	124	37	7	IPR001881
Domain	EGF_extracell	LTBP2 ADAM11 LRP1B ITGB6 SVEP1	1.16e-07	60	37	5	IPR013111
Domain	EGF_2	LTBP2 ADAM11 LRP1B ITGB6 SVEP1	1.16e-07	60	37	5	PF07974
Domain	EGF	CD93 LTBP2 ZAN HMCN1 LRP1B SVEP1	1.64e-07	126	37	6	PF00008
Domain	TB	LTBP2 LTBP3 FBN1	2.49e-07	7	37	3	PF00683
Domain	-	LTBP2 LTBP3 FBN1	3.98e-07	8	37	3	3.90.290.10
Domain	TB	LTBP2 LTBP3 FBN1	5.96e-07	9	37	3	PS51364
Domain	TB_dom	LTBP2 LTBP3 FBN1	5.96e-07	9	37	3	IPR017878
Domain	TMEM9	TMEM9B TMEM9	3.82e-06	2	37	2	IPR008853
Domain	Tmemb_9	TMEM9B TMEM9	3.82e-06	2	37	2	PF05434
Domain	CONNEXINS_1	GJB2 GJB3 GJB6	6.79e-06	19	37	3	PS00407
Domain	Connexin_N	GJB2 GJB3 GJB6	7.97e-06	20	37	3	IPR013092
Domain	CONNEXINS_2	GJB2 GJB3 GJB6	7.97e-06	20	37	3	PS00408
Domain	Connexin	GJB2 GJB3 GJB6	7.97e-06	20	37	3	PF00029
Domain	Connexin_CCC	GJB2 GJB3 GJB6	7.97e-06	20	37	3	SM01089
Domain	Connexin_CS	GJB2 GJB3 GJB6	7.97e-06	20	37	3	IPR017990
Domain	Connexin	GJB2 GJB3 GJB6	7.97e-06	20	37	3	IPR000500
Domain	Connexin_CCC	GJB2 GJB3 GJB6	7.97e-06	20	37	3	IPR019570
Domain	CNX	GJB2 GJB3 GJB6	7.97e-06	20	37	3	SM00037
Domain	EGF_LAM_2	NTN5 LAMA3 LAMB1	2.80e-05	30	37	3	PS50027
Domain	EGF_LAM_1	NTN5 LAMA3 LAMB1	2.80e-05	30	37	3	PS01248
Domain	Laminin_EGF	NTN5 LAMA3 LAMB1	4.48e-05	35	37	3	PF00053
Domain	EGF_Lam	NTN5 LAMA3 LAMB1	4.48e-05	35	37	3	SM00180
Domain	Laminin_EGF	NTN5 LAMA3 LAMB1	5.76e-05	38	37	3	IPR002049
Domain	ZINC_FINGER_C2H2_2	GLIS3 ZNF462 ZNF57 ZNF143 ZSCAN25 ZNF474 GLIS1 ZNF426	1.12e-04	775	37	8	PS50157
Domain	ZINC_FINGER_C2H2_1	GLIS3 ZNF462 ZNF57 ZNF143 ZSCAN25 ZNF474 GLIS1 ZNF426	1.14e-04	777	37	8	PS00028
Domain	Znf_C2H2	GLIS3 ZNF462 ZNF57 ZNF143 ZSCAN25 ZNF474 GLIS1 ZNF426	1.46e-04	805	37	8	IPR007087
Domain	-	HMCN1 SVEP1	2.08e-04	11	37	2	2.40.155.10
Domain	GFP-like	HMCN1 SVEP1	2.08e-04	11	37	2	IPR023413
Domain	-	GLIS3 ZNF462 ZNF57 ZNF143 ZSCAN25 GLIS1 ZNF426	3.23e-04	679	37	7	3.30.160.60
Domain	zf-C2H2	GLIS3 ZNF462 ZNF57 ZNF143 ZSCAN25 GLIS1 ZNF426	3.66e-04	693	37	7	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	GLIS3 ZNF462 ZNF57 ZNF143 ZSCAN25 GLIS1 ZNF426	3.69e-04	694	37	7	IPR013087
Domain	-	HMCN1 ITGB6 SVEP1	4.21e-04	74	37	3	3.40.50.410
Domain	LAMININ_NTER	LAMA3 LAMB1	4.50e-04	16	37	2	PS51117
Domain	Laminin_N	LAMA3 LAMB1	4.50e-04	16	37	2	PF00055
Domain	Laminin_N	LAMA3 LAMB1	4.50e-04	16	37	2	IPR008211
Domain	LamNT	LAMA3 LAMB1	4.50e-04	16	37	2	SM00136
Domain	VWFA	HMCN1 ITGB6 SVEP1	5.69e-04	82	37	3	PS50234
Domain	VWA	HMCN1 ITGB6 SVEP1	6.11e-04	84	37	3	SM00327
Domain	Znf_C2H2-like	GLIS3 ZNF462 ZNF57 ZNF143 ZSCAN25 GLIS1 ZNF426	8.36e-04	796	37	7	IPR015880
Domain	ZnF_C2H2	GLIS3 ZNF462 ZNF57 ZNF143 ZSCAN25 GLIS1 ZNF426	9.13e-04	808	37	7	SM00355
Domain	VWF_A	HMCN1 ITGB6 SVEP1	9.85e-04	99	37	3	IPR002035
Domain	hEGF	LTBP3 SVEP1	1.40e-03	28	37	2	PF12661
Domain	VWFC_1	CHRDL1 ZAN	2.31e-03	36	37	2	PS01208
Domain	VWC	CHRDL1 ZAN	2.57e-03	38	37	2	SM00214
Domain	VWFC_2	CHRDL1 ZAN	2.57e-03	38	37	2	PS50184
Domain	VWF_dom	CHRDL1 ZAN	3.13e-03	42	37	2	IPR001007
Pathway	REACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES	LTBP2 LTBP3 FBN1 ITGB6	3.70e-07	32	27	4	MM14854
Pathway	REACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES	LTBP2 LTBP3 FBN1 ITGB6	6.75e-07	37	27	4	M27134
Pathway	REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS	LTBP2 LTBP3 FBN1 ITGB6	7.53e-07	38	27	4	MM14874
Pathway	REACTOME_ELASTIC_FIBRE_FORMATION	LTBP2 LTBP3 FBN1 ITGB6	8.38e-07	39	27	4	MM14601
Pathway	REACTOME_ELASTIC_FIBRE_FORMATION	LTBP2 LTBP3 FBN1 ITGB6	1.37e-06	44	27	4	M26969
Pathway	REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS	LTBP2 LTBP3 FBN1 ITGB6	1.80e-06	47	27	4	M646
Pathway	REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS	CHRDL1 LTBP2 LTBP3 FBN1 ITGB6	2.63e-06	118	27	5	MM15588
Pathway	REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS	CHRDL1 LTBP2 LTBP3 FBN1 ITGB6	1.20e-05	161	27	5	M27871
Pathway	REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX	LTBP2 LTBP3 FBN1 ITGB6	1.31e-05	77	27	4	MM14670
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	LAMA3 LAMB1 LTBP2 LTBP3 FBN1 ITGB6	1.79e-05	300	27	6	M610
Pathway	REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX	LTBP2 LTBP3 FBN1 ITGB6	2.89e-05	94	27	4	M1041
Pathway	REACTOME_GAP_JUNCTION_ASSEMBLY	GJB2 GJB3 GJB6	2.99e-05	32	27	3	MM14730
Pathway	REACTOME_GAP_JUNCTION_ASSEMBLY	GJB2 GJB3 GJB6	5.05e-05	38	27	3	M14981
Pathway	REACTOME_GAP_JUNCTION_TRAFFICKING_AND_REGULATION	GJB2 GJB3 GJB6	7.88e-05	44	27	3	MM14606
Pathway	KEGG_MEDICUS_REFERENCE_PLASMIN_MEDIATED_ACTIVATION_OF_LATENT_TGF_BETA	LTBP3 FBN1	9.82e-05	8	27	2	M47850
Pathway	REACTOME_GAP_JUNCTION_TRAFFICKING_AND_REGULATION	GJB2 GJB3 GJB6	1.23e-04	51	27	3	M26972
Pathway	WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS	LTBP3 FBN1 ITGB6	1.90e-04	59	27	3	M39886
Pathway	PID_INTEGRIN4_PATHWAY	LAMA3 LAMB1	1.92e-04	11	27	2	M158
Pathway	PID_INTEGRIN1_PATHWAY	LAMA3 LAMB1 FBN1	2.65e-04	66	27	3	M18
Pathway	REACTOME_ECM_PROTEOGLYCANS	LAMA3 LAMB1 ITGB6	4.01e-04	76	27	3	M27219
Pathway	PID_INTEGRIN5_PATHWAY	FBN1 ITGB6	4.72e-04	17	27	2	M212
Pathway	KEGG_ECM_RECEPTOR_INTERACTION	LAMA3 LAMB1 ITGB6	5.38e-04	84	27	3	M7098
Pathway	WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE	LTBP2 FBN1	1.03e-03	25	27	2	M39713
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	LTBP2 LTBP3 FBN1 ITGB6	1.38e-03	258	27	4	MM14572
Pathway	REACTOME_MET_ACTIVATES_PTK2_SIGNALING	LAMA3 LAMB1	1.49e-03	30	27	2	M27772
Pathway	WP_INFLAMMATORY_RESPONSE_PATHWAY	LAMB1 TNFRSF1A	1.49e-03	30	27	2	MM15812
Pathway	REACTOME_LAMININ_INTERACTIONS	LAMA3 LAMB1	1.49e-03	30	27	2	M27216
Pathway	WP_INFLAMMATORY_RESPONSE_PATHWAY	LAMB1 TNFRSF1A	1.49e-03	30	27	2	M39641
Pathway	REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_TRANSPORT_AND_UPTAKE_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS	LAMB1 CHRDL1 FBN1	1.67e-03	124	27	3	M27285
Pathway	WP_ALPHA_6_BETA_4_SIGNALING	LAMA3 LAMB1	1.80e-03	33	27	2	M39503
Pathway	REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX	LAMA3 LAMB1 FBN1	2.35e-03	140	27	3	M587
Pathway	WP_FOCAL_ADHESION_PI3KAKTMTORSIGNALING	LAMA3 LAMB1 ITGB6 EPAS1	2.46e-03	302	27	4	M39719
Pathway	WP_CALCIUM_REGULATION_IN_CARDIAC_CELLS	GJB2 GJB3 GJB6	2.70e-03	147	27	3	MM15854
Pathway	REACTOME_MET_PROMOTES_CELL_MOTILITY	LAMA3 LAMB1	2.77e-03	41	27	2	M27778
Pathway	WP_CALCIUM_REGULATION_IN_CARDIAC_CELLS	GJB2 GJB3 GJB6	2.92e-03	151	27	3	M39329
Pathway	PID_INTEGRIN3_PATHWAY	LAMB1 FBN1	3.04e-03	43	27	2	M53
Pathway	WP_FOCAL_ADHESION_PI3KAKTMTOR_SIGNALING_PATHWAY	LAMA3 LAMB1 ITGB6 EPAS1	3.24e-03	326	27	4	MM15917
Pathway	PID_A6B1_A6B4_INTEGRIN_PATHWAY	LAMA3 LAMB1	3.47e-03	46	27	2	M239
Pathway	WP_FOCAL_ADHESION	LAMA3 LAMB1 ITGB6	5.32e-03	187	27	3	MM15913
Pathway	REACTOME_NON_INTEGRIN_MEMBRANE_ECM_INTERACTIONS	LAMA3 LAMB1	5.65e-03	59	27	2	M27218
Pathway	KEGG_FOCAL_ADHESION	LAMA3 LAMB1 ITGB6	6.31e-03	199	27	3	M7253
Pathway	WP_FOCAL_ADHESION	LAMA3 LAMB1 ITGB6	6.31e-03	199	27	3	M39402
Pubmed	[Mutation analysis of GJB2, GJB3 and GJB6 gene in deaf population from special educational school of Chifeng city].	GJB2 GJB3 GJB6	1.20e-09	3	38	3	18338563
Pubmed	[The roles of connexin genes in sporadic hearing loss population].	GJB2 GJB3 GJB6	1.20e-09	3	38	3	17672988
Pubmed	Mutational analysis for GJB2, GJB6, and GJB3 genes in Campania within a universal neonatal hearing screening programme.	GJB2 GJB3 GJB6	1.20e-09	3	38	3	21916817
Pubmed	GJB2-Related Autosomal Recessive Nonsyndromic Hearing Loss	GJB2 GJB3 GJB6	1.20e-09	3	38	3	20301449
Pubmed	Digenic inheritance of non-syndromic deafness caused by mutations at the gap junction proteins Cx26 and Cx31.	GJB2 GJB3 GJB6	1.20e-09	3	38	3	19050930
Pubmed	Mutation analysis of the Cx26, Cx30, and Cx31 genes in autosomal recessive nonsyndromic hearing impairment.	GJB2 GJB3 GJB6	1.20e-09	3	38	3	18607988
Pubmed	Absence of GJB3 and GJB6 mutations in Moroccan familial and sporadic patients with autosomal recessive non-syndromic deafness.	GJB2 GJB3 GJB6	1.20e-09	3	38	3	18809214
Pubmed	Mutation in gap and tight junctions in patients with non-syndromic hearing loss.	GJB2 GJB3 GJB6	4.81e-09	4	38	3	19254696
Pubmed	GJB2 mutations in patients with nonsyndromic hearing loss from Croatia.	GJB2 GJB3 GJB6	4.81e-09	4	38	3	19814620
Pubmed	Mutational analysis of the mitochondrial 12S rRNA and tRNASer(UCN) genes in Tunisian patients with nonsyndromic hearing loss.	GJB2 GJB3 GJB6	1.20e-08	5	38	3	16406239
Pubmed	Prospective variants screening of connexin genes in children with hearing impairment: genotype/phenotype correlation.	GJB2 GJB3 GJB6	2.40e-08	6	38	3	20593197
Pubmed	Comprehensive molecular etiology analysis of nonsyndromic hearing impairment from typical areas in China.	GJB2 GJB3 GJB6	2.40e-08	6	38	3	19744334
Pubmed	[Etiologic analysis of severe to profound hearing loss patients from Chifeng city in Inner Mongolia].	GJB2 GJB3 GJB6	4.20e-08	7	38	3	19558834
Pubmed	Splice variant IVS2-2A>G in the SLC26A5 (Prestin) gene in five Estonian families with hearing loss.	GJB2 GJB3 GJB6	6.71e-08	8	38	3	19027966
Pubmed	Genetic analysis of presbycusis by arrayed primer extension.	GJB2 GJB3 GJB6	6.71e-08	8	38	3	18988928
Pubmed	Genotyping with a 198 mutation arrayed primer extension array for hereditary hearing loss: assessment of its diagnostic value for medical practice.	GJB2 GJB3 GJB6	6.71e-08	8	38	3	20668687
Pubmed	Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins.	GJB2 GJB3 GJB6	1.01e-07	9	38	3	19864490
Pubmed	Gap junctions in the inner ear: comparison of distribution patterns in different vertebrates and assessement of connexin composition in mammals.	GJB2 GJB3 GJB6	1.01e-07	9	38	3	14595769
Pubmed	Analysis of gene polymorphisms associated with K ion circulation in the inner ear of patients susceptible and resistant to noise-induced hearing loss.	GJB2 GJB3 GJB6	1.44e-07	10	38	3	19523148
Pubmed	Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.	LAMA3 LAMB1 LTBP2 LTBP3 FBN1	5.46e-07	146	38	5	27068509
Pubmed	An expression atlas of connexin genes in the mouse.	GJB2 GJB3 GJB6	9.71e-07	18	38	3	15081111
Pubmed	The novel mouse connexin39 gene is expressed in developing striated muscle fibers.	GJB2 GJB3 GJB6	9.71e-07	18	38	3	15466892
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	LAMA3 LAMB1 LTBP2 FBN1 HMCN1	1.06e-06	167	38	5	22159717
Pubmed	An update on connexin genes and their nomenclature in mouse and man.	GJB2 GJB3 GJB6	1.15e-06	19	38	3	14681012
Pubmed	Frequency of GJB2 mutations, GJB6-D13S1830 and GJB6-D13S1854 deletions among patients with non-syndromic hearing loss from the central region of Iran.	GJB2 GJB6	1.16e-06	2	38	2	31162818
Pubmed	The lysosomal transmembrane protein 9B regulates the activity of inflammatory signaling pathways.	TMEM9B TMEM9	1.16e-06	2	38	2	18541524
Pubmed	First report of prevalence c.IVS1+1G>A and del (GJB6-13S1854) mutations in Syrian families with non-syndromic sensorineural hearing loss.	GJB2 GJB6	1.16e-06	2	38	2	28012540
Pubmed	The digenic hypothesis unraveled: the GJB6 del(GJB6-D13S1830) mutation causes allele-specific loss of GJB2 expression in cis.	GJB2 GJB6	1.16e-06	2	38	2	19723508
Pubmed	A study of GJB2 and delGJB6-D13S1830 mutations in Brazilian non-syndromic deaf children from the Amazon region.	GJB2 GJB6	1.16e-06	2	38	2	23503914
Pubmed	Prevalence of DFNB1 mutations among cochlear implant users in Slovakia and its clinical implications.	GJB2 GJB6	1.16e-06	2	38	2	23700267
Pubmed	[New recurrent extended deletion, including GJB2 and GJB6 genes, results in isolated sensorineural hearing impairment with autosomal recessive type of inheritance].	GJB2 GJB6	1.16e-06	2	38	2	25715449
Pubmed	A novel DFNB1 deletion allele supports the existence of a distant cis-regulatory region that controls GJB2 and GJB6 expression.	GJB2 GJB6	1.16e-06	2	38	2	20236118
Pubmed	Connexin 26 variants and auditory neuropathy/dys-synchrony among children in schools for the deaf.	GJB2 GJB6	1.16e-06	2	38	2	16222667
Pubmed	Genetic analysis of the contribution of LTBP-3 to thoracic aneurysm in Marfan syndrome.	LTBP3 FBN1	1.16e-06	2	38	2	26494287
Pubmed	Connexin26 gap junction mediates miRNA intercellular genetic communication in the cochlea and is required for inner ear development.	GJB2 GJB6	1.16e-06	2	38	2	26490746
Pubmed	Prevalence of DFNB1 mutations in Argentinean children with non-syndromic deafness. Report of a novel mutation in GJB2.	GJB2 GJB6	1.16e-06	2	38	2	20022641
Pubmed	GJB2 and GJB6 genes: molecular study and identification of novel GJB2 mutations in the hearing-impaired Argentinean population.	GJB2 GJB6	1.16e-06	2	38	2	19887791
Pubmed	Hearing impairment in Dutch patients with connexin 26 (GJB2) and connexin 30 (GJB6) mutations.	GJB2 GJB6	1.16e-06	2	38	2	15656949
Pubmed	The association between GJB2 mutation and GJB6 gene in non syndromic hearing loss school children.	GJB2 GJB6	1.16e-06	2	38	2	22106692
Pubmed	GJB2 and GJB6 Genetic Variant Curation in an Argentinean Non-Syndromic Hearing-Impaired Cohort.	GJB2 GJB6	1.16e-06	2	38	2	33096615
Pubmed	Mutation R184Q of connexin 26 in hearing loss patients has a dominant-negative effect on connexin 26 and connexin 30.	GJB2 GJB6	1.16e-06	2	38	2	20442751
Pubmed	Melanoma progression exhibits a significant impact on connexin expression patterns in the epidermal tumor microenvironment.	GJB2 GJB6	1.16e-06	2	38	2	19844737
Pubmed	8-Cysteine TGF-BP structural motifs are the site of covalent binding between mouse LTBP-3, LTBP-2, and latent TGF-beta 1.	LTBP2 LTBP3	1.16e-06	2	38	2	9602168
Pubmed	Common mutation analysis of GJB2 and GJB6 genes in affected families with autosomal recessive non-syndromic hearing loss from Iran: simultaneous detection of two common mutations (35delG/del(GJB6-D13S1830)) in the DFNB1-related deafness.	GJB2 GJB6	1.16e-06	2	38	2	17368814
Pubmed	Connexin Type and Fluorescent Protein Fusion Tag Determine Structural Stability of Gap Junction Plaques.	GJB2 GJB6	1.16e-06	2	38	2	26265468
Pubmed	GJB2 and GJB6 mutations are an infrequent cause of autosomal-recessive nonsyndromic hearing loss in residents of Mexico.	GJB2 GJB6	1.16e-06	2	38	2	25288386
Pubmed	GJB2 (connexin 26) variants and nonsyndromic sensorineural hearing loss: a HuGE review.	GJB2 GJB6	1.16e-06	2	38	2	12172392
Pubmed	Prevalence of DFNB1 mutations in Slovak patients with non-syndromic hearing loss.	GJB2 GJB6	1.16e-06	2	38	2	22281373
Pubmed	Particular distribution of the GJB2/GJB6 gene mutations in Mexican population with hearing impairment.	GJB2 GJB6	1.16e-06	2	38	2	24774219
Pubmed	GJB2 mutation spectrum in 209 hearing impaired individuals of predominantly Caribbean Hispanic and African descent.	GJB2 GJB6	1.16e-06	2	38	2	20381175
Pubmed	LTBP3 Pathogenic Variants Predispose Individuals to Thoracic Aortic Aneurysms and Dissections.	LTBP3 FBN1	1.16e-06	2	38	2	29625025
Pubmed	Infant hearing loss and connexin testing in a diverse population.	GJB2 GJB6	1.16e-06	2	38	2	18580690
Pubmed	The spectrum of GJB2 gene mutations in Algerian families with nonsyndromic hearing loss from Sahara and Kabylie regions.	GJB2 GJB6	1.16e-06	2	38	2	31200317
Pubmed	Phenotypic variability of non-syndromic hearing loss in patients heterozygous for both c.35delG of GJB2 and the 342-kb deletion involving GJB6.	GJB2 GJB6	1.16e-06	2	38	2	14759569
Pubmed	Mutation analysis of GJB2 and GJB6 genes in Southeastern Brazilians with hereditary nonsyndromic deafness.	GJB2 GJB6	1.16e-06	2	38	2	20563649
Pubmed	Double heterozygosity with mutations involving both the GJB2 and GJB6 genes is a possible, but very rare, cause of congenital deafness in the Czech population.	GJB2 GJB6	1.16e-06	2	38	2	15638823
Pubmed	The connexin31 F137L mutant mouse as a model for the human skin disease erythrokeratodermia variabilis (EKV).	GJB3 GJB6	1.16e-06	2	38	2	17446259
Pubmed	Decreased expression of connexin-30 and aberrant expression of connexin-26 in human head and neck cancer.	GJB2 GJB6	1.16e-06	2	38	2	17695503
Pubmed	Phenotype/genotype correlations in a DFNB1 cohort with ethnical diversity.	GJB2 GJB6	1.16e-06	2	38	2	18758381
Pubmed	Performance of speech perception after cochlear implantation in DFNB1 patients.	GJB2 GJB6	1.16e-06	2	38	2	19051073
Pubmed	GJB2 and GJB6 gene mutations found in Indian probands with congenital hearing impairment.	GJB2 GJB6	1.16e-06	2	38	2	20086291
Pubmed	Non-syndromic hearing impairment in a multi-ethnic population of Northeastern Brazil.	GJB2 GJB6	1.16e-06	2	38	2	23684175
Pubmed	A deletion mutation in GJB6 cooperating with a GJB2 mutation in trans in non-syndromic deafness: A novel founder mutation in Ashkenazi Jews.	GJB2 GJB6	1.16e-06	2	38	2	11668644
Pubmed	Evaluation of the pathogenicity of GJB3 and GJB6 variants associated with nonsyndromic hearing loss.	GJB3 GJB6	1.16e-06	2	38	2	22617145
Pubmed	Pediatric cholesteatoma and variants in the gene encoding connexin 26.	GJB2 GJB6	1.16e-06	2	38	2	19877196
Pubmed	Detection of the 35delG/GJB2 and del(GJB6-D13S1830) mutations in Venezuelan patients with autosomal recessive nonsyndromic hearing loss.	GJB2 GJB6	1.16e-06	2	38	2	18294049
Pubmed	Hearing loss features in GJB2 biallelic mutations and GJB2/GJB6 digenic inheritance in a large Italian cohort.	GJB2 GJB6	1.16e-06	2	38	2	19173109
Pubmed	Prevalence of GJB2 mutations and the del(GJB6-D13S1830) in Argentinean non-syndromic deaf patients.	GJB2 GJB6	1.16e-06	2	38	2	15964725
Pubmed	Screening for the GJB2 c.-3170 G>A (IVS 1+1 G>A) mutation in Brazilian deaf individuals using multiplex ligation-dependent probe amplification.	GJB2 GJB6	1.16e-06	2	38	2	19715470
Pubmed	Connexins 26 and 30 are co-assembled to form gap junctions in the cochlea of mice.	GJB2 GJB6	1.16e-06	2	38	2	12859965
Pubmed	[Sequence analysis of GJB3 in Chinese deafness population who carry one heterozygous GJB2 pathogenic mutation].	GJB2 GJB3	1.16e-06	2	38	2	20627047
Pubmed	Frequency and distribution of GJB2 (connexin 26) and GJB6 (connexin 30) mutations in a large North American repository of deaf probands.	GJB2 GJB6	1.16e-06	2	38	2	12865758
Pubmed	Genotyping for Cx26 and Cx30 mutations in cases with congenital hearing loss.	GJB2 GJB6	1.16e-06	2	38	2	18554165
Pubmed	Connexin gene mutations among Ugandan patients with nonsyndromic sensorineural hearing loss.	GJB2 GJB6	1.16e-06	2	38	2	24706568
Pubmed	GJB2 and GJB6 mutations in 165 Danish patients showing non-syndromic hearing impairment.	GJB2 GJB6	1.16e-06	2	38	2	15345117
Pubmed	Permeation pathway of homomeric connexin 26 and connexin 30 channels investigated by molecular dynamics.	GJB2 GJB6	1.16e-06	2	38	2	22292956
Pubmed	Connexin 26 and 30 genes mutations in patients with chronic rhinosinusitis.	GJB2 GJB6	1.16e-06	2	38	2	17989577
Pubmed	GJB2 and GJB6 screening in Tunisian patients with autosomal recessive deafness.	GJB2 GJB6	1.16e-06	2	38	2	23434199
Pubmed	Novel connexin 30 and connexin 26 mutational spectrum in patients with progressive sensorineural hearing loss.	GJB2 GJB6	1.16e-06	2	38	2	22704424
Pubmed	Low incidence of GJB2, GJB6 and mitochondrial DNA mutations in North Indian patients with non-syndromic hearing impairment.	GJB2 GJB6	1.16e-06	2	38	2	19465004
Pubmed	In vivo genetic manipulation of inner ear connexin expression by bovine adeno-associated viral vectors.	GJB2 GJB6	1.16e-06	2	38	2	28779115
Pubmed	Screening for monogenetic del(GJB6-D13S1830) and digenic del(GJB6-D13S1830)/GJB2 patterns of inheritance in deaf individuals from Eastern Austria.	GJB2 GJB6	1.16e-06	2	38	2	15464308
Pubmed	Prevalence of the GJB2 mutations and the del(GJB6-D13S1830) mutation in Brazilian patients with deafness.	GJB2 GJB6	1.16e-06	2	38	2	15464305
Pubmed	Connexin 26 and connexin 30 mutations in children with nonsyndromic hearing loss.	GJB2 GJB6	1.16e-06	2	38	2	15064611
Pubmed	Analysis of the presence of the GJB6 mutations in patients heterozygous for GJB2 mutation in Brazil.	GJB2 GJB6	1.16e-06	2	38	2	23553242
Pubmed	Connexin-Mediated Signaling in Nonsensory Cells Is Crucial for the Development of Sensory Inner Hair Cells in the Mouse Cochlea.	GJB2 GJB6	1.16e-06	2	38	2	28077706
Pubmed	Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein.	LTBP2 LTBP3	1.16e-06	2	38	2	7798248
Pubmed	Restoration of connexin26 protein level in the cochlea completely rescues hearing in a mouse model of human connexin30-linked deafness.	GJB2 GJB6	1.16e-06	2	38	2	17227867
Pubmed	Identification of Glis1, a novel Gli-related, Kruppel-like zinc finger protein containing transactivation and repressor functions.	GLIS3 GLIS1	1.16e-06	2	38	2	12042312
Pubmed	A large deletion including most of GJB6 in recessive non syndromic deafness: a digenic effect?	GJB2 GJB6	1.16e-06	2	38	2	11896458
Pubmed	Connexin 26 and 30 mutations in paediatric patients with congenital, non-syndromic hearing loss treated with cochlear implantation in Mediterranean Turkey.	GJB2 GJB6	1.16e-06	2	38	2	23171692
Pubmed	Clouston syndrome with heterozygous GJB6 mutation p.Ala88Val and GJB2 variant p.Val27Ile revealing mild sensorineural hearing loss and photophobia.	GJB2 GJB6	1.16e-06	2	38	2	23863883
Pubmed	Etiology of unilateral hearing loss in a national hereditary deafness repository.	GJB2 GJB6	1.16e-06	2	38	2	22534022
Pubmed	Human connexin26 and connexin30 form functional heteromeric and heterotypic channels.	GJB2 GJB6	1.16e-06	2	38	2	17615163
Pubmed	Screening for GJB2 and GJB6 gene mutations in patients from Campania region with sensorineural hearing loss.	GJB2 GJB6	1.16e-06	2	38	2	20233142
Pubmed	Analysis of the GJB2 and GJB6 genes in Italian patients with nonsyndromic hearing loss: frequencies, novel mutations, genotypes, and degree of hearing loss.	GJB2 GJB6	1.16e-06	2	38	2	19371219
Pubmed	Nonsyndromic Hearing Loss and Deafness, DFNA3 – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	GJB2 GJB6	1.16e-06	2	38	2	20301708
Pubmed	Gap junction-mediated intercellular biochemical coupling in cochlear supporting cells is required for normal cochlear functions.	GJB2 GJB6	1.16e-06	2	38	2	16217030
Pubmed	Connexin mutations associated with palmoplantar keratoderma and profound deafness in a single family.	GJB2 GJB3	1.16e-06	2	38	2	10757647
Pubmed	Mice with conditional deletion of Cx26 exhibit no vestibular phenotype despite secondary loss of Cx30 in the vestibular end organs.	GJB2 GJB6	1.16e-06	2	38	2	26232528
Interaction	FBN2 interactions	NTN5 LTBP2 FBN1 SVEP1	6.70e-06	65	38	4	int:FBN2
Interaction	GJB6 interactions	GJB2 GJB3 GJB6	9.29e-06	22	38	3	int:GJB6
Interaction	GJA3 interactions	GJB2 GJB3 TMEM9	9.29e-06	22	38	3	int:GJA3
Interaction	IGFL3 interactions	LAMA3 LAMB1 ADAM11 LRP1B	1.19e-05	75	38	4	int:IGFL3
Interaction	GJB3 interactions	GJB2 GJB3 GJB6	1.22e-05	24	38	3	int:GJB3
Interaction	NTN5 interactions	NTN5 FBN1 LRP1B	1.22e-05	24	38	3	int:NTN5
Interaction	CNST interactions	GJB2 GJB3 GJB6	1.56e-05	26	38	3	int:CNST
Interaction	CLCN4 interactions	TMEM9B TMEM9	7.23e-05	7	38	2	int:CLCN4
Interaction	CHRDL1 interactions	CHRDL1 LRP1B	1.88e-04	11	38	2	int:CHRDL1
Interaction	HRG interactions	FBN1 TNFRSF1A LRP1B	2.27e-04	63	38	3	int:HRG
Interaction	ZNF709 interactions	GATA3 LTBP2	2.67e-04	13	38	2	int:ZNF709
Interaction	GJB2 interactions	GJB2 GJB3 GJB6	2.85e-04	68	38	3	int:GJB2
Cytoband	7q22	LAMB1 ZAN	4.60e-04	38	38	2	7q22
GeneFamily	Gap junction proteins	GJB2 GJB3 GJB6	6.21e-06	22	30	3	314
GeneFamily	Latent transforming growth factor beta binding proteins	LTBP2 LTBP3	1.59e-05	4	30	2	628
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	GLIS3 ZNF462 ZNF57 ZNF143 ZSCAN25 ZNF474 GLIS1 ZNF426	1.60e-05	718	30	8	28
GeneFamily	Laminin subunits	LAMA3 LAMB1	1.74e-04	12	30	2	626
GeneFamily	Actins\|Deafness associated genes	GJB2 GJB3 GJB6	8.53e-04	113	30	3	1152
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	ADAM11 ADAM5	9.10e-04	27	30	2	47
Coexpression	NABA_ECM_GLYCOPROTEINS	NTN5 LAMA3 LAMB1 LTBP2 LTBP3 FBN1 HMCN1 SVEP1	2.78e-10	191	38	8	MM17059
Coexpression	NABA_ECM_GLYCOPROTEINS	NTN5 LAMA3 LAMB1 LTBP2 LTBP3 FBN1 HMCN1 SVEP1	3.42e-10	196	38	8	M3008
Coexpression	NABA_CORE_MATRISOME	NTN5 LAMA3 LAMB1 LTBP2 LTBP3 FBN1 HMCN1 SVEP1	4.28e-09	270	38	8	MM17057
Coexpression	NABA_CORE_MATRISOME	NTN5 LAMA3 LAMB1 LTBP2 LTBP3 FBN1 HMCN1 SVEP1	4.94e-09	275	38	8	M5884
Coexpression	NABA_MATRISOME	NTN5 LAMA3 LAMB1 CHRDL1 INHBE LTBP2 LTBP3 FBN1 ADAM11 HMCN1 SVEP1 ADAM5	1.05e-08	1008	38	12	MM17056
Coexpression	NABA_MATRISOME	NTN5 LAMA3 LAMB1 CHRDL1 INHBE LTBP2 LTBP3 FBN1 ADAM11 HMCN1 SVEP1	1.43e-07	1026	38	11	M5889
Coexpression	NABA_BASEMENT_MEMBRANES	NTN5 LAMA3 LAMB1 HMCN1	3.31e-07	40	38	4	M5887
Coexpression	SASAI_RESISTANCE_TO_NEOPLASTIC_TRANSFROMATION	GJB3 LTBP2 FBN1 TNFRSF1A	8.24e-07	50	38	4	M1259
Coexpression	SASAI_RESISTANCE_TO_NEOPLASTIC_TRANSFROMATION	GJB3 LTBP2 FBN1 TNFRSF1A	9.67e-07	52	38	4	MM1118
Coexpression	LIU_PROSTATE_CANCER_DN	GATA3 LAMB1 CHRDL1 FBN1 ITGB6 GLIS1 EPAS1	6.08e-06	493	38	7	M19391
Coexpression	SCHLESINGER_METHYLATED_DE_NOVO_IN_CANCER	LAMA3 CHRDL1 GJB2 FBN1	8.02e-06	88	38	4	M11288
Coexpression	IZADPANAH_STEM_CELL_ADIPOSE_VS_BONE_DN	GATA3 LAMB1 LTBP2 FBN1	1.74e-05	107	38	4	M4913
Coexpression	MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3	GLIS3 SCNN1G LAMB1 GJB2 HMCN1 GLIS1 EPAS1 SVEP1 GJB6	1.75e-05	1074	38	9	M1941
Coexpression	BOQUEST_STEM_CELL_UP	CHRDL1 LTBP2 FBN1 LRP1B SVEP1	3.62e-05	261	38	5	M1834
Coexpression	GSE5589_WT_VS_IL6_KO_LPS_STIM_MACROPHAGE_180MIN_UP	SCNN1G TMEM9 ADAM5 FAM76A	4.72e-05	138	38	4	M6678
Coexpression	ZHOU_CELL_CYCLE_GENES_IN_IR_RESPONSE_2HR	ZNF462 LAMB1	5.70e-05	8	38	2	M2604
Coexpression	NABA_MATRISOME_PRIMARY_METASTATIC_COLORECTAL_TUMOR	LTBP2 HMCN1 SVEP1	8.64e-05	59	38	3	M47989
Coexpression	HAY_BONE_MARROW_STROMAL	CHRDL1 LTBP2 FBN1 TNFRSF1A ITGB6 EPAS1 SVEP1	1.02e-04	767	38	7	M39209
Coexpression	WU_CELL_MIGRATION	GATA3 LAMA3 GJB3 EPAS1	1.41e-04	183	38	4	M2001
Coexpression	SESTO_RESPONSE_TO_UV_C8	LAMA3 LAMB1 GJB2	1.50e-04	71	38	3	M2948
Coexpression	BENPORATH_ES_WITH_H3K27ME3	GATA3 SCNN1G LAMB1 CHRDL1 GJB2 LTBP2 FBN1 EPAS1	1.64e-04	1115	38	8	M10371
Coexpression	HE_LIM_SUN_FETAL_LUNG_C1_PROXIMAL_BASAL_CELL	GLIS3 SCNN1G GJB2 EPAS1	1.73e-04	193	38	4	M45706
Coexpression	KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3	GATA3 ZNF462 LTBP2 LTBP3 ZNF143 ZSCAN25 TNFRSF1A	1.83e-04	843	38	7	M2356
Coexpression	GSE17721_LPS_VS_POLYIC_24H_BMDC_DN	CD93 ADAM11 TNFRSF1A SVEP1	1.94e-04	199	38	4	M3821
Coexpression	GSE17721_CTRL_VS_CPG_6H_BMDC_UP	CD93 ADAM11 APLF FAM76A	1.98e-04	200	38	4	M3764
Coexpression	GSE6092_UNSTIM_VS_IFNG_STIM_AND_B_BURGDORFERI_INF_ENDOTHELIAL_CELL_DN	CHRDL1 INHBE GJB3 FBN1	1.98e-04	200	38	4	M6715
Coexpression	GSE2826_WT_VS_BTK_KO_BCELL_DN	GATA3 ADAM11 TNFRSF1A EPAS1	1.98e-04	200	38	4	M4899
Coexpression	DESCARTES_FETAL_CEREBRUM_ASTROCYTES	GLIS3 GJB2 ZNF474 GJB6	2.22e-04	206	38	4	M40171
Coexpression	ONDER_CDH1_SIGNALING_VIA_CTNNB1	LTBP2 FBN1 EPAS1	2.47e-04	84	38	3	M15484
Coexpression	HE_LIM_SUN_FETAL_LUNG_C3_VENOUS_ENDOTHELIAL_CELL	LTBP3 FBN1 HMCN1	2.56e-04	85	38	3	M45761
Coexpression	THUM_MIR21_TARGETS_HEART_DISEASE_UP	LTBP2 SVEP1	3.09e-04	18	38	2	M13796
Coexpression	THUM_MIR21_TARGETS_HEART_DISEASE_UP	LTBP2 SVEP1	3.09e-04	18	38	2	MM1241
Coexpression	HOSHIDA_LIVER_CANCER_SUBCLASS_S1	LAMB1 LTBP2 LTBP3 FBN1	3.66e-04	235	38	4	M5311
Coexpression	MASRI_RESISTANCE_TO_TAMOXIFEN_AND_AROMATASE_INHIBITORS_DN	ITGB6 EPAS1	3.83e-04	20	38	2	M1991
Coexpression	MEBARKI_HCC_PROGENITOR_WNT_UP_CTNNB1_INDEPENDENT	FBN1 ZNF474	5.54e-04	24	38	2	M38986
Coexpression	BENPORATH_SUZ12_TARGETS	GATA3 SCNN1G LAMA3 GJB2 LTBP2 FBN1 EPAS1	6.33e-04	1035	38	7	M9898
CoexpressionAtlas	Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5	LAMB1 CHRDL1 LTBP3 FBN1 HMCN1 EPAS1 SVEP1	9.26e-06	466	35	7	GSM777050_500
CoexpressionAtlas	Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5	CHRDL1 FBN1 EPAS1 SVEP1	1.25e-05	87	35	4	GSM777050_100
CoexpressionAtlas	ratio_EmbryoidBody_vs_StemCell_top-relative-expression-ranked_1000	GATA3 GLIS3 LTBP2 FBN1 ZNF474 LRP1B ITGB6 EPAS1 SVEP1	2.44e-05	994	35	9	PCBC_ratio_EB_vs_SC_1000
CoexpressionAtlas	kidney_adult_JuxtaGlom_Ren1_Captopr_top-relative-expression-ranked_500	GATA3 SCNN1G CD93 GJB2 ITGB6 EPAS1	4.78e-05	406	35	6	gudmap_kidney_adult_JuxtaGlom_Ren1_Captopr_500
CoexpressionAtlas	Stromal Cells, LEC.MLN, gp38+ CD31+, Lymph Node, avg-4	CD93 LAMB1 LTBP2 FBN1 HMCN1 EPAS1	7.37e-05	439	35	6	GSM777059_500
CoexpressionAtlas	Stromal Cells, LEC.SLN, gp38+ CD31+, Lymph Node, avg-4	CD93 LAMB1 LTBP2 FBN1 HMCN1 EPAS1	8.44e-05	450	35	6	GSM777063_500
CoexpressionAtlas	Stromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4	LAMB1 CHRDL1 LTBP2 FBN1 EPAS1 SVEP1	8.97e-05	455	35	6	GSM777055_500
CoexpressionAtlas	ratio_EmbryoidBody_vs_StemCell_top-relative-expression-ranked_500	GATA3 GLIS3 LRP1B ITGB6 EPAS1 SVEP1	1.47e-04	498	35	6	PCBC_ratio_EB_vs_SC_500
CoexpressionAtlas	dev lower uro neuro_e14.5_PelvicGanglion_Sox10_k-means-cluster#2_top-relative-expression-ranked_1000	CD93 GJB3 FBN1	1.52e-04	63	35	3	gudmap_dev lower uro neuro_e14.5_PelvicGanglion_Sox10_k2_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_P2_bladder urothelium (LCM)_emap-30380_k-means-cluster#5_top-relative-expression-ranked_1000	GATA3 SCNN1G LAMA3 GJB2	1.60e-04	167	35	4	gudmap_developingLowerUrinaryTract_P2_bladder urothelium (LCM)_1000_k5
CoexpressionAtlas	ratio_EmbryoidBody_vs_StemCell_top-relative-expression-ranked_1000_k-means-cluster#1	GLIS3 LTBP2 FBN1 EPAS1 SVEP1	2.12e-04	336	35	5	ratio_EB_vs_SC_1000_K1
CoexpressionAtlas	kidney_adult_RenalCapsule_top-relative-expression-ranked_1000	CHRDL1 LTBP2 LTBP3 FBN1 HMCN1 EPAS1 SVEP1	2.37e-04	778	35	7	gudmap_kidney_adult_RenalCapsule_1000
CoexpressionAtlas	e10.5_ColumEpith_Mandib_top-relative-expression-ranked_500	GATA3 GJB2 GJB3 HMCN1 GJB6	2.46e-04	347	35	5	Facebase_ST1_e10.5_ColumEpith_Mandib_500
CoexpressionAtlas	kidney_adult_RenalCapsule_k-means-cluster#2_top-relative-expression-ranked_1000	CHRDL1 LTBP2 LTBP3 FBN1 SVEP1	3.26e-04	369	35	5	gudmap_kidney_adult_RenalCapsule_k2_1000
CoexpressionAtlas	ratio_EmbryoidBody_vs_StemCell_top-relative-expression-ranked_2500_k-means-cluster#3	GATA3 GLIS3 LTBP2 FBN1 ZNF474 HMCN1 LRP1B SVEP1	3.28e-04	1094	35	8	ratio_EB_vs_SC_2500_K3
CoexpressionAtlas	DevelopingKidney_e15.5_cortic collect duct_emap-28132_top-relative-expression-ranked_100	GATA3 SCNN1G LAMB1	3.44e-04	83	35	3	gudmap_developingKidney_e15.5_cortic collect duct_100
CoexpressionAtlas	Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2	CHRDL1 FBN1 EPAS1	3.69e-04	85	35	3	GSM777067_100
CoexpressionAtlas	gudmap_RNAseq_p2_CD2APMEISWT_2500_K4	GATA3 GLIS3 GJB2 LTBP3 FBN1 TMEM9B EPAS1	3.82e-04	842	35	7	gudmap_RNAseq_p2_CD2APMEISWT_2500_K4
CoexpressionAtlas	mendel_RNAseq_e12.5_Urothelium_ShhCreRFP_2500_K1	GATA3 SCNN1G LAMA3 GJB3 ITGB6	4.82e-04	402	35	5	mendel_RNAseq_e12.5_Urothelium_ShhCreRFP_2500_K1
CoexpressionAtlas	Progenitor-Cell-Biology-Consortium_reference_SmallAirwayEpithel_top-relative-expression-ranked_100	LAMA3 GJB2 GJB3	5.60e-04	98	35	3	PCBC_ctl_SmallAirwayEpithel_100
CoexpressionAtlas	Progenitor-Cell-Biology-Consortium_reference_BronchioEpithel_top-relative-expression-ranked_100	LAMA3 GJB2 GJB3	5.60e-04	98	35	3	PCBC_ctl_BronchioEpithel_100
CoexpressionAtlas	kidney_P0_JuxtaGlom_Ren1_top-relative-expression-ranked_1000	GATA3 SCNN1G CD93 GJB2 FBN1 ITGB6 EPAS1	5.89e-04	905	35	7	gudmap_kidney_P0_JuxtaGlom_Ren1_1000
CoexpressionAtlas	kidney_adult_RenalCapsule_k-means-cluster#1_top-relative-expression-ranked_500	CHRDL1 FBN1 HMCN1 SVEP1	6.33e-04	240	35	4	gudmap_kidney_adult_RenalCapsule_k1_500
CoexpressionAtlas	Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4	LAMB1 CHRDL1 FBN1 HMCN1 SVEP1	7.04e-04	437	35	5	GSM777046_500
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_MedNas_2500_K2	GATA3 ITGB6 GJB6	7.85e-04	110	35	3	facebase_RNAseq_e10.5_Emin_MedNas_2500_K2
CoexpressionAtlas	Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2	LAMB1 CHRDL1 FBN1 EPAS1 SVEP1	8.28e-04	453	35	5	GSM777067_500
CoexpressionAtlas	Stromal Cells, BEC.MLN, gp38- CD31+, Lymph Node, avg-5	LAMA3 CD93 LAMB1 LTBP2 EPAS1	8.52e-04	456	35	5	GSM777032_500
CoexpressionAtlas	kidney_P0_JuxtaGlom_Ren1_top-relative-expression-ranked_500	GATA3 CD93 FBN1 ITGB6 EPAS1	8.52e-04	456	35	5	gudmap_kidney_P0_JuxtaGlom_Ren1_500
CoexpressionAtlas	Stromal Cells, BEC.SLN, gp38- CD31+, Lymph Node, avg-4	LAMA3 CD93 LAMB1 LTBP2 EPAS1	8.78e-04	459	35	5	GSM777037_500
CoexpressionAtlas	dev gonad_e13.5_M_InterstitTestis_Sma_k-means-cluster#1_top-relative-expression-ranked_100	FBN1 HMCN1	9.03e-04	27	35	2	gudmap_dev gonad_e13.5_M_InterstitTestis_Sma_k1_100
CoexpressionAtlas	FacebaseRNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_1000	GATA3 GLIS3 LTBP2 LTBP3 FBN1 GLIS1 EPAS1	9.05e-04	973	35	7	Facebase_RNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_1000
CoexpressionAtlas	JC_fibro_top-relative-expression-ranked_1000_k-means-cluster#1	LTBP2 FBN1 GLIS1 EPAS1 SVEP1	9.21e-04	464	35	5	JC_fibro_1000_K1
CoexpressionAtlas	AravindRamakr_EmbryoidBody-LF_top-relative-expression-ranked_1000	GLIS3 INHBE GJB2 HMCN1 ITGB6 GLIS1 SVEP1	9.50e-04	981	35	7	Arv_EB-LF_1000
CoexpressionAtlas	Progenitor-Cell-Biology-Consortium_reference_BronchSmoothMuscl_top-relative-expression-ranked_1000	GLIS3 LAMA3 GJB2 LTBP2 FBN1 GLIS1 SVEP1	9.50e-04	981	35	7	PCBC_ctl_BronchSmoothMuscl_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e15.5_Urothelium_emap-28091_k-means-cluster#1_top-relative-expression-ranked_500	GATA3 SCNN1G LAMA3	9.62e-04	118	35	3	gudmap_developingLowerUrinaryTract_e15.5_Urothelium_500_k1
CoexpressionAtlas	gudmap_RNAseq_e11.5_Ureteric_bud_2500_K0	GATA3 SCNN1G LAMA3 GJB3 ITGB6 GJB6	9.77e-04	711	35	6	gudmap_RNAseq_e11.5_Ureteric_bud_2500_K0
CoexpressionAtlas	mendel_RNAseq_e17.5_Urothelium_ShhCreRFP_2500_K1	GATA3 SCNN1G LAMA3 GJB2 GJB3 ITGB6 GJB6	9.84e-04	987	35	7	mendel_RNAseq_e17.5_Urothelium_ShhCreRFP_2500_K1
CoexpressionAtlas	Progenitor-Cell-Biology-Consortium_reference_SmallAirwayEpithel_top-relative-expression-ranked_1000	LAMA3 GJB2 GJB3 LTBP2 ITGB6 EPAS1 GJB6	9.84e-04	987	35	7	PCBC_ctl_SmallAirwayEpithel_1000
CoexpressionAtlas	DevelopingKidney_e15.5_ureter tip_flank cortic collct_emap-27752_k-means-cluster#5_top-relative-expression-ranked_100	GATA3 SCNN1G	1.04e-03	29	35	2	gudmap_developingKidney_e15.5_ureter tip_flank cortic collct_100_k5
CoexpressionAtlas	facebase_RNAseq_e10.5_MaxArch_2500_K4	GJB3 ITGB6 GJB6	1.08e-03	123	35	3	facebase_RNAseq_e10.5_MaxArch_2500_K4
ToppCell	Adult-Mesenchymal-chondrocyte\|Adult / Lineage, Cell type, age group and donor	LAMB1 LTBP2 FBN1 ADAM11 HMCN1 SVEP1	4.45e-09	159	38	6	3f7305ee76447064b5c846c4f576360a2f7e0b7c
ToppCell	Adult-Mesenchymal-chondrocyte-D231\|Adult / Lineage, Cell type, age group and donor	LAMB1 LTBP2 FBN1 ADAM11 HMCN1 SVEP1	5.36e-09	164	38	6	2ba57dce5f69a88f0d1e450b9780425e2d9ca7d4
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LAMB1 CHRDL1 LTBP2 FBN1 HMCN1 SVEP1	1.14e-08	186	38	6	5473283fb95cee556b1f6934cf72169b676b5bcc
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_Carcinoma-6\|TCGA-Breast / Sample_Type by Project: Shred V9	GLIS3 LAMB1 GJB2 LTBP2 FBN1 HMCN1	1.18e-08	187	38	6	a96495803ba13fcfadd1d83b3cf5774f3fed0a20
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	GLIS3 LAMB1 LTBP2 FBN1 EPAS1 SVEP1	1.38e-08	192	38	6	60b1312e84f6d6448365a952469c506c00b5fe93
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LAMB1 CHRDL1 LTBP2 FBN1 HMCN1 SVEP1	1.51e-08	195	38	6	df409f94f4e83be89f7a608058ee07ce3ce3a149
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LAMB1 CHRDL1 LTBP2 FBN1 HMCN1 SVEP1	1.51e-08	195	38	6	4243190ad291d56694e2155954dbaa879c9d3844
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LAMB1 CHRDL1 LTBP2 FBN1 HMCN1 SVEP1	1.56e-08	196	38	6	42e9828222a9663525d571633e8a454c30bfa7f8
ToppCell	nucseq-Mesenchymal-Fibroblastic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	LAMB1 CHRDL1 LTBP2 FBN1 HMCN1 SVEP1	1.56e-08	196	38	6	7d8505dac15fa59935ccf592afc54b04c4c6554f
ToppCell	metastatic_Lymph_Node-Fibroblasts\|metastatic_Lymph_Node / Location, Cell class and cell subclass	LAMB1 CHRDL1 GJB2 LTBP2 FBN1 HMCN1	1.56e-08	196	38	6	275e153347caf94edc0c50021bbab49c8696fecb
ToppCell	COVID-19-Fibroblasts-Intermediate_pathological_FB\|COVID-19 / group, cell type (main and fine annotations)	GLIS3 LAMB1 LTBP2 FBN1 HMCN1 SVEP1	1.60e-08	197	38	6	f1c8936986123a3151140c374fcd62d6705c530b
ToppCell	COVID-19-Fibroblasts\|COVID-19 / group, cell type (main and fine annotations)	GLIS3 LAMB1 LTBP2 FBN1 HMCN1 SVEP1	1.60e-08	197	38	6	fb847f2277609c31fffcdf49517243ce0684facf
ToppCell	COVID-19-lung-Fibroblast\|COVID-19 / Disease (COVID-19 only), tissue and cell type	LAMB1 CHRDL1 LTBP2 FBN1 HMCN1 SVEP1	1.65e-08	198	38	6	3ec01a55ade5e1627258cc3cfebb2c3207a4cb43
ToppCell	Parenchymal-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	LAMB1 CHRDL1 LTBP2 FBN1 HMCN1 SVEP1	1.65e-08	198	38	6	300d7cc56207d77168390fa1ffcbcf76767b1b80
ToppCell	COVID-19-lung-Fibroblast\|lung / Disease (COVID-19 only), tissue and cell type	GLIS3 LAMB1 LTBP2 FBN1 HMCN1 SVEP1	1.65e-08	198	38	6	df3de77216f5c5d6141ec44d01c56b942f611838
ToppCell	cellseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	LAMB1 CHRDL1 LTBP2 FBN1 HMCN1 SVEP1	1.65e-08	198	38	6	f1374f7a50244d59c766ac41f44c08c9117407d2
ToppCell	Biopsy_Control_(H.)-Mesenchymal-Myofibroblasts\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	LAMB1 CHRDL1 LTBP2 FBN1 HMCN1 SVEP1	1.70e-08	199	38	6	7a227c239afdaebcac84644d9b2653a5f1a4be71
ToppCell	ASK452-Mesenchymal-Fibroblast\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	LAMB1 CHRDL1 LTBP2 FBN1 HMCN1 SVEP1	1.70e-08	199	38	6	4d0bf2a4bd97e5a3bfe4570a201cc21bb9c4c1f6
ToppCell	ASK452-Mesenchymal\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	LAMB1 CHRDL1 LTBP2 FBN1 HMCN1 SVEP1	1.70e-08	199	38	6	93e85e3731a9ece9aee3eb82c5dfdad331ee62d6
ToppCell	Bronchial-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	LAMB1 LTBP2 FBN1 HMCN1 GLIS1 SVEP1	1.70e-08	199	38	6	e1f1950d6f840485e263b83dc81b98910be3ae7a
ToppCell	cellseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	LAMB1 CHRDL1 LTBP2 FBN1 HMCN1 SVEP1	1.70e-08	199	38	6	66a79732caf2f04c09b4d9832377aa01ca477677
ToppCell	Biopsy_Other_PF-Mesenchymal-Myofibroblasts\|Biopsy_Other_PF / Sample group, Lineage and Cell type	LAMB1 CHRDL1 LTBP2 FBN1 HMCN1 SVEP1	1.76e-08	200	38	6	e504570fd7eec1524c401b1cfa9d10822d80d994
ToppCell	cellseq-Mesenchymal-Fibroblastic\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	LAMB1 CHRDL1 LTBP2 FBN1 HMCN1 SVEP1	1.76e-08	200	38	6	8978867bf69c830b1e48cac2ad6b512dbe60f149
ToppCell	Parenchymal-10x5prime-Stromal-Fibroblastic-Fibro_alveolar\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	LAMB1 CHRDL1 LTBP2 FBN1 HMCN1 SVEP1	1.76e-08	200	38	6	8c62f05c6042f24287a73fbdf80ff4a56f7ff403
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	ZNF462 LAMB1 CHRDL1 LTBP2 LTBP3 FBN1	1.76e-08	200	38	6	09537dc25f8b8b4654a7c183827ee1522a41a4e0
ToppCell	Parenchymal-10x5prime-Stromal-Fibroblastic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	LAMB1 CHRDL1 LTBP2 FBN1 HMCN1 SVEP1	1.76e-08	200	38	6	6e3d1ae0ef84d3075afa40129a41169996462672
ToppCell	Biopsy_Other_PF-Mesenchymal\|Biopsy_Other_PF / Sample group, Lineage and Cell type	LAMB1 CHRDL1 LTBP2 FBN1 HMCN1 SVEP1	1.76e-08	200	38	6	d6fcdd48858b53b5a8d18ae14b2dc4d9af41b070
ToppCell	Parenchymal-10x5prime-Stromal-Fibroblastic-Fibro_myofibroblast\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	LAMB1 CHRDL1 LTBP2 FBN1 HMCN1 SVEP1	1.76e-08	200	38	6	54806080b5e97859ee6a4a9b4f19e22021c218f5
ToppCell	(01)_IL1RL1+\|World / shred by cell type by condition	LAMA3 LAMB1 GJB2 GJB3 ITGB6 GJB6	1.76e-08	200	38	6	501420901bf3ec1b050e0d14596a9f9f3fdfc928
ToppCell	PND01-03-samps-Epithelial-Alveolar_epithelial-AT1_-_meso\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	SCNN1G LAMA3 INHBE ZSCAN25 ITGB6	1.77e-07	150	38	5	6a13e4c4b9c9e54a5016573a37132465ec1c8f99
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LAMB1 CHRDL1 LTBP2 FBN1 HMCN1	3.80e-07	175	38	5	1799a7be623dc3bf53ba580a7c47d2619969d708
ToppCell	343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	LAMB1 CHRDL1 FBN1 LRP1B SVEP1	3.91e-07	176	38	5	2e94bbe17c0bb65dc58b4ebc0cb829258bd7373b
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-COL13A1+_matrix_FBs\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	CHRDL1 LTBP2 FBN1 HMCN1 SVEP1	3.91e-07	176	38	5	510f9a14dc1c151d24d079e0cc004cdf4f86336c
ToppCell	343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)\|343B / Donor, Lineage, Cell class and subclass (all cells)	LAMB1 CHRDL1 FBN1 LRP1B SVEP1	3.91e-07	176	38	5	f33ab41d121b59d871ad7d48ca021524a027d2ef
ToppCell	facs-Heart-RA-24m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GATA3 SCNN1G CD93 HMCN1 EPAS1	4.37e-07	180	38	5	174c643e046646e3b305dd7e5b120d2c9a46690f
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LAMB1 CHRDL1 LTBP2 FBN1 HMCN1	4.49e-07	181	38	5	b116c68393d8836bac080f81a8fcbeb52e0403e7
ToppCell	metastatic_Brain-Fibroblasts-Myofibroblasts\|metastatic_Brain / Location, Cell class and cell subclass	LAMB1 LTBP2 FBN1 HMCN1 SVEP1	4.49e-07	181	38	5	bd0b5f74f9c81ec0f1592710774a4fdf33d9d5a9
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CD93 FBN1 ZAN HMCN1 EPAS1	4.62e-07	182	38	5	d0e3663f7d39f22a3ebd7fde56ab3504773598f4
ToppCell	COVID-19-Heart-Fib_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GLIS3 LAMB1 LTBP2 FBN1 SVEP1	5.01e-07	185	38	5	8f95d8e591bf7379d13f5a0545b0cb49e2b1ab5d
ToppCell	(0)_MSCs\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	LAMB1 CHRDL1 LTBP2 FBN1 SVEP1	5.14e-07	186	38	5	a832c1e0035bcd559722eccf262c145deb3494c7
ToppCell	(0)_MSCs-(00)_Lepr-MSC\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	LAMB1 CHRDL1 LTBP2 FBN1 SVEP1	5.14e-07	186	38	5	f0d156167d7cc2cd8a76e5a364233e9f2170bc01
ToppCell	Mesenchymal_cells-Adipo-CAR\|World / Lineage and Cell class	LAMB1 CHRDL1 LTBP2 EPAS1 SVEP1	5.14e-07	186	38	5	6ca8ce7ced91d6308b7c056032ffec1b37c974bf
ToppCell	Control-Fibroblasts-Alveolar_FB\|Control / group, cell type (main and fine annotations)	LAMB1 LTBP2 FBN1 HMCN1 SVEP1	5.28e-07	187	38	5	92d468dde81125d51daf7abd4703741abe1ab91c
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB1 CHRDL1 GJB3 FBN1 SVEP1	5.28e-07	187	38	5	4e553721fa5598cb211f44e3226280b7e6885484
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB1 CHRDL1 GJB3 FBN1 SVEP1	5.28e-07	187	38	5	d36e7fc6125e7a4310499365022d38f34b757a73
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB1 CHRDL1 GJB3 FBN1 SVEP1	5.28e-07	187	38	5	827eae63fabf6892a82ce7779b5f395958d3d628
ToppCell	Control-Fibroblasts-Other_FB\|Control / group, cell type (main and fine annotations)	LAMB1 LTBP2 FBN1 HMCN1 SVEP1	5.28e-07	187	38	5	bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCell	E17.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	GATA3 CD93 FBN1 HMCN1 EPAS1	5.42e-07	188	38	5	59f276e23c8380bae57d7ecca3a8b83df4bc150b
ToppCell	-Donor_07\|World / lung cells shred on cell class, cell subclass, sample id	LAMB1 CHRDL1 LTBP2 FBN1 SVEP1	5.42e-07	188	38	5	038f48e8daaeb72716e975d22a6b004a90654960
ToppCell	COVID-19-Heart-Fib_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GLIS3 LAMB1 LTBP2 FBN1 SVEP1	5.42e-07	188	38	5	fe361215f4ba841aa5e1e581fb56f2f4d3ccd201
ToppCell	COVID-19-kidney-CD-PC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GATA3 GLIS3 SCNN1G LAMB1 LRP1B	5.42e-07	188	38	5	8f9996c3f3b27efaaae8960a66af77412de9c7ef
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GATA3 GLIS3 SCNN1G LAMB1 LRP1B	5.42e-07	188	38	5	4154f4787483c7e076e87a187733a9f666742c3d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GATA3 GLIS3 SCNN1G LAMB1 LRP1B	5.56e-07	189	38	5	90aae7e806882bebfad78a78e9a16cf56af3ecd4
ToppCell	E17.5-Endothelial-large_vessel_endothelial_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	GATA3 CD93 FBN1 HMCN1 EPAS1	5.56e-07	189	38	5	360f09f46231a83f99d8fa0158b72a38068e1642
ToppCell	droplet-Pancreas-PANCREAS-30m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA3 CD93 LAMB1 HMCN1 EPAS1	5.71e-07	190	38	5	9d5242759546be0089981ef1877e4ed5f81face5
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GATA3 GLIS3 SCNN1G LAMB1 LRP1B	5.71e-07	190	38	5	4836ea19308d2a96694f12ab0653b7ce7b101d2f
ToppCell	Control-Fibroblasts\|Control / group, cell type (main and fine annotations)	LAMB1 LTBP2 FBN1 HMCN1 SVEP1	5.71e-07	190	38	5	3a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCell	ASK440-Mesenchymal\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	CHRDL1 LTBP2 FBN1 HMCN1 SVEP1	5.86e-07	191	38	5	f12959eebb4167e1aa03de05d7711a702c58b3c9
ToppCell	ASK454-Mesenchymal\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	LAMB1 CHRDL1 LTBP2 FBN1 SVEP1	5.86e-07	191	38	5	e30ae7a12439f8a79820b13f03e822c1223fd0cb
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LAMB1 CHRDL1 LTBP2 FBN1 HMCN1	5.86e-07	191	38	5	0fae1c2ef9f83ac7721d0a9d69455bf97eed9257
ToppCell	LV-02._Fibroblast_II\|World / Chamber and Cluster_Paper	GLIS3 LAMB1 LTBP2 FBN1 SVEP1	5.86e-07	191	38	5	d36565257ccba8c1bbed2c1c01be66a9cbb5f834
ToppCell	ASK454-Mesenchymal-Fibroblast\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	LAMB1 CHRDL1 LTBP2 FBN1 SVEP1	5.86e-07	191	38	5	1726add3f392a061536b7aff72ba84303f4a0b1f
ToppCell	metastatic_Lymph_Node-Fibroblasts-Myofibroblasts\|metastatic_Lymph_Node / Location, Cell class and cell subclass	LAMB1 GJB2 LTBP2 FBN1 HMCN1	5.86e-07	191	38	5	aa43b472bc8362f79ae63f09f1ca764718bbf22c
ToppCell	ASK440-Mesenchymal-Fibroblast\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	CHRDL1 LTBP2 FBN1 HMCN1 SVEP1	5.86e-07	191	38	5	387296b5377ef6839f0812e5b3529a10b5f7d530
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	LAMB1 LTBP2 FBN1 HMCN1 SVEP1	5.86e-07	191	38	5	6688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCell	COVID-19-kidney-CNT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GATA3 GLIS3 SCNN1G LRP1B ITGB6	6.01e-07	192	38	5	760c6b9628de9693034b00c5025c5c4df94bb2e8
ToppCell	nucseq-Mesenchymal-Myocytic-Myocytic_2-SCMF\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	LAMB1 GJB2 LTBP2 FBN1 HMCN1	6.01e-07	192	38	5	67e845e513e76e820f55e2f0d15eb16f2944d05c
ToppCell	COVID-19-kidney-CNT\|kidney / Disease (COVID-19 only), tissue and cell type	GATA3 SCNN1G LAMB1 LRP1B ITGB6	6.01e-07	192	38	5	d32ae226d95b4b6adb99d14b602be09b661d4cd9
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	LAMB1 LTBP2 FBN1 HMCN1 SVEP1	6.01e-07	192	38	5	99ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCell	droplet-Lung-30m-Mesenchymal-fibroblast-adventitial_fibroblast\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LAMB1 CHRDL1 GJB3 FBN1 SVEP1	6.17e-07	193	38	5	9d0b966d13cbce97beb43de6dc77f006c363a181
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.4.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LAMB1 CHRDL1 LTBP2 FBN1 SVEP1	6.17e-07	193	38	5	5bee7abc550ddaa28cbb3b9ecaf6b924ab175de0
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D231\|Adult / Lineage, Cell type, age group and donor	LAMB1 LTBP2 FBN1 HMCN1 SVEP1	6.17e-07	193	38	5	ef2f456c094e6e3c6ee81e0668c953cb8d0e1c0a
ToppCell	LA\|World / Chamber and Cluster_Paper	GLIS3 LTBP2 FBN1 LRP1B SVEP1	6.17e-07	193	38	5	d4bf89437216baf489ea0239136dcedf3b6714af
ToppCell	LV-01._Fibroblast_I\|LV / Chamber and Cluster_Paper	GLIS3 LAMB1 LTBP2 FBN1 SVEP1	6.17e-07	193	38	5	dc17f3b9758936d428cf17f77a1ce6d4c479b165
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	GLIS3 LAMB1 FBN1 HMCN1 SVEP1	6.33e-07	194	38	5	011e14d9ed1393275f892060e7708ffadcd0767f
ToppCell	Control-Fibroblasts-Intermediate_pathological_FB\|Control / group, cell type (main and fine annotations)	LAMB1 LTBP2 FBN1 HMCN1 SVEP1	6.33e-07	194	38	5	03a269f75a481ea54aea8e6444605db8d6df493d
ToppCell	LV-02._Fibroblast_II\|LV / Chamber and Cluster_Paper	GLIS3 LAMB1 LTBP2 FBN1 SVEP1	6.33e-07	194	38	5	014d2feb5db2a6a35ef759761a41e466e108c3c1
ToppCell	COVID-19-Heart-Fib_2\|Heart / Disease (COVID-19 only), tissue and cell type	GLIS3 LAMB1 LTBP2 FBN1 SVEP1	6.33e-07	194	38	5	d91c9f2ec47319051fc398320693fddbe8bbd4d6
ToppCell	Control-Stromal-Myofibroblast\|World / Disease state, Lineage and Cell class	LAMB1 CHRDL1 LTBP2 HMCN1 SVEP1	6.33e-07	194	38	5	3c2266772c5b56e8e02a461e5193e29588028ee9
ToppCell	COVID-19-Heart-Fib_1\|Heart / Disease (COVID-19 only), tissue and cell type	GLIS3 LAMB1 LTBP2 FBN1 SVEP1	6.49e-07	195	38	5	f423baa36ac7cdc383c033e35a7d17e6bf913323
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell\|Adult / Lineage, Cell type, age group and donor	LAMB1 LTBP2 FBN1 HMCN1 SVEP1	6.49e-07	195	38	5	61c9e09fc84d1012e472185d70ad0a06cee30d6e
ToppCell	COVID-19-Fibroblasts-Alveolar_FB\|COVID-19 / group, cell type (main and fine annotations)	LAMB1 LTBP2 FBN1 HMCN1 SVEP1	6.49e-07	195	38	5	603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LAMB1 CHRDL1 LTBP2 FBN1 SVEP1	6.49e-07	195	38	5	1236dc60288c7dd91868e86e9174a2dacd3b11b3
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	LAMB1 LTBP2 FBN1 ADAM11 HMCN1	6.49e-07	195	38	5	f5e91ce20a7ce528dc4c1a968c7bf096bf45c528
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LAMB1 CHRDL1 LTBP2 HMCN1 SVEP1	6.66e-07	196	38	5	9737a5f006d37b549f281e1863aca558e1e4dc99
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LAMB1 CHRDL1 LTBP2 HMCN1 SVEP1	6.66e-07	196	38	5	cecf82cd5e0a3835d655f5e7478578674a63ce25
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LAMB1 CHRDL1 LTBP2 HMCN1 SVEP1	6.83e-07	197	38	5	94a9603cbd3516fbcce871909693b88f20d41713
ToppCell	COPD-Stromal-Myofibroblast\|World / Disease state, Lineage and Cell class	LAMB1 CHRDL1 LTBP2 HMCN1 SVEP1	6.83e-07	197	38	5	d51f484b4e01ac64233950d0b97fa88825ea1dbb
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal-mesenchymal-mesenchymal_stem_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	LAMB1 CHRDL1 FBN1 LRP1B SVEP1	6.83e-07	197	38	5	3bb92dd8a94e2be3b7fe51c9a21b241215477ac7
ToppCell	10x3'2.3-week_17-19-Mesenchymal_adipo\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	GLIS3 ZNF462 LTBP2 FBN1 SVEP1	6.83e-07	197	38	5	5afddde4e2b5cd55abe11e9b9efae02dbdc3da3a
ToppCell	10x3'2.3-week_17-19-Mesenchymal_adipo-stroma-adipo-CAR\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	GLIS3 ZNF462 LTBP2 FBN1 SVEP1	6.83e-07	197	38	5	1baffd087ca194a7355fefbb3bf67befb14fe2de
ToppCell	normal_Lung-Fibroblasts-COL13A1+_matrix_FBs\|normal_Lung / Location, Cell class and cell subclass	LAMB1 CHRDL1 LTBP2 HMCN1 SVEP1	6.83e-07	197	38	5	6c57ab2efb8363828e24211c4d45e58bb73a9a4d
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	LAMB1 LTBP2 FBN1 HMCN1 SVEP1	6.83e-07	197	38	5	44673c38384453207871d3fd8e8ba9093cc06bc5
ToppCell	10x3'2.3-week_17-19-Mesenchymal_adipo-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	GLIS3 ZNF462 LTBP2 FBN1 SVEP1	6.83e-07	197	38	5	b9745e382baa2725dfcae060701fb53f6c8a31fa
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	LAMB1 CHRDL1 FBN1 LRP1B SVEP1	6.83e-07	197	38	5	17344464fdcc5ba0c03959696b97c195f11e644c
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LAMB1 CHRDL1 LTBP2 HMCN1 SVEP1	6.83e-07	197	38	5	13896ec65ccda0b928c91d41112dc01b480036b7
ToppCell	distal-1-Epithelial-Basal\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LAMA3 GJB2 GJB3 MYRFL GJB6	6.83e-07	197	38	5	25a2ccc98b973611de0d920b1b455d0b40f0d37f
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal-mesenchymal\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	LAMB1 CHRDL1 FBN1 LRP1B SVEP1	6.83e-07	197	38	5	5b8d0d7116b20d8e27541e88ec80c9f1f477e384
ToppCell	Adult-Mesenchymal\|Adult / Lineage, Cell type, age group and donor	LAMB1 LTBP2 FBN1 HMCN1 SVEP1	7.00e-07	198	38	5	26e55b409db2a1637c95fae7c54b0abea1ef550c
ToppCell	nucseq-Mesenchymal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	LAMB1 LTBP2 FBN1 HMCN1 SVEP1	7.00e-07	198	38	5	8f52243ca8b9ba68a75ae411506a3a6de258eb97
Computational	Genes upregulated in subsets of cells of a given type within various tumors	LAMA3 GJB2 GJB3	6.15e-05	50	17	3	GAVISH_3CA_METAPROGRAM_EPITHELIAL_EPI3
Computational	ECM and collagens.	LAMB1 GJB2 LTBP2 FBN1	3.59e-04	225	17	4	MODULE_47
Computational	Neighborhood of CDH11	LAMB1 FBN1	6.91e-04	25	17	2	GNF2_CDH11
Computational	Neighborhood of CDH3	LAMA3 GJB3	8.07e-04	27	17	2	GNF2_CDH3
Computational	Neighborhood of SERPINB5	LAMA3 GJB3	8.69e-04	28	17	2	GNF2_SERPINB5
Computational	Adhesion molecules.	LAMA3 LAMB1 FBN1	1.31e-03	141	17	3	MODULE_122
Computational	Neighborhood of PTX3	LAMB1 FBN1	1.44e-03	36	17	2	GNF2_PTX3
Computational	Genes upregulated in subsets of cells of a given type within various tumors	GATA3 SCNN1G	2.76e-03	50	17	2	GAVISH_3CA_METAPROGRAM_EPITHELIAL_METABOLISM_KIDNEY_2
Computational	Genes upregulated in subsets of cells of a given type within various tumors	CD93 EPAS1	2.76e-03	50	17	2	GAVISH_3CA_METAPROGRAM_ENDOTHELIAL_ENDO_3
Computational	Genes upregulated in subsets of cells of a given type within various tumors	LAMA3 ITGB6	2.76e-03	50	17	2	GAVISH_3CA_MALIGNANT_METAPROGRAM_13_EMT_2
Disease	DEAFNESS, AUTOSOMAL RECESSIVE 1A	GJB2 GJB3 GJB6	1.53e-09	3	35	3	220290
Disease	DEAFNESS, DIGENIC, GJB2/GJB6 (disorder)	GJB2 GJB3 GJB6	1.53e-09	3	35	3	C2673760
Disease	DEAFNESS, DIGENIC, GJB2/GJB3 (disorder)	GJB2 GJB3 GJB6	1.53e-09	3	35	3	C2673761
Disease	DEAFNESS, AUTOSOMAL RECESSIVE 1A (disorder)	GJB2 GJB3 GJB6	1.53e-09	3	35	3	C2673759
Disease	Autosomal recessive nonsyndromic hearing loss 1A	GJB2 GJB3 GJB6	1.53e-09	3	35	3	cv:C2673759
Disease	autosomal recessive nonsyndromic deafness 1A (implicated_via_orthology)	GJB2 GJB6	1.37e-06	2	35	2	DOID:0110475 (implicated_via_orthology)
Disease	Keratitis-Ichthyosis-Deafness Syndrome	GJB2 GJB6	1.37e-06	2	35	2	C3665333
Disease	DFNA 3 Nonsyndromic Hearing Loss and Deafness	GJB2 GJB6	1.37e-06	2	35	2	cv:CN043589
Disease	Senter syndrome	GJB2 GJB6	1.37e-06	2	35	2	C0265336
Disease	autosomal recessive nonsyndromic deafness 1A (is_implicated_in)	GJB2 GJB6	1.37e-06	2	35	2	DOID:0110475 (is_implicated_in)
Disease	Deafness, digenic, GJB2/GJB3	GJB2 GJB3	1.37e-06	2	35	2	cv:C2673761
Disease	Sensorineural Hearing Loss (disorder)	GLIS3 GJB2 GJB3	2.66e-06	23	35	3	C0018784
Disease	Deafness, autosomal dominant nonsyndromic sensorineural 3	GJB2 GJB6	4.10e-06	3	35	2	cv:
Disease	Progressive hearing loss stapes fixation	GJB2 GJB6	4.10e-06	3	35	2	C1844678
Disease	Weill-Marchesani syndrome	LTBP2 FBN1	4.10e-06	3	35	2	C0265313
Disease	Weill-Marchesani Syndrome, Autosomal Dominant	LTBP2 FBN1	4.10e-06	3	35	2	C1869115
Disease	Weill-Marchesani Syndrome, Autosomal Recessive	LTBP2 FBN1	4.10e-06	3	35	2	C1869114
Disease	X-linked mixed hearing loss with perilymphatic gusher	GJB2 GJB6	4.10e-06	3	35	2	cv:C1844678
Disease	DEAFNESS, X-LINKED 2	GJB2 GJB6	4.10e-06	3	35	2	304400
Disease	Autosomal dominant nonsyndromic hearing loss	GJB2 GJB3 GJB6	5.47e-06	29	35	3	cv:C5779548
Disease	Weill-Marchesani syndrome	LTBP2 FBN1	8.19e-06	4	35	2	cv:C0265313
Disease	Weill-Marchesani syndrome (is_implicated_in)	LTBP2 FBN1	8.19e-06	4	35	2	DOID:0050475 (is_implicated_in)
Disease	Mitral valve prolapse	LTBP2 LTBP3 GLIS1	1.06e-05	36	35	3	HP_0001634
Disease	Geleophysic dysplasia	LTBP3 FBN1	1.36e-05	5	35	2	C3489726
Disease	Acromicric Dysplasia	LTBP3 FBN1	1.36e-05	5	35	2	C0265287
Disease	Hydrophthalmos	GLIS3 LTBP2	1.36e-05	5	35	2	C0020302
Disease	Hidrotic Ectodermal Dysplasia	GJB2 GJB6	1.36e-05	5	35	2	C0162361
Disease	Amelogenesis imperfecta local hypoplastic form	LAMA3 ITGB6	2.86e-05	7	35	2	C0399367
Disease	cholesteryl ester 16:2 measurement	LTBP2 LTBP3	2.86e-05	7	35	2	EFO_0021435
Disease	Nonsyndromic Hearing Loss and Deafness, Autosomal Recessive	GJB2 GJB3 GJB6	3.06e-05	51	35	3	cv:CN043650
Disease	lymphocyte count	GATA3 GLIS3 INHBE LTBP2 LTBP3 FBN1 ZSCAN25 TNFRSF1A ZAN	3.89e-05	1464	35	9	EFO_0004587
Disease	Pulmonary Cystic Fibrosis	SCNN1G TNFRSF1A	4.89e-05	9	35	2	C0392164
Disease	Fibrocystic Disease of Pancreas	SCNN1G TNFRSF1A	4.89e-05	9	35	2	C1527396
Disease	fish oil supplement exposure measurement, triglyceride measurement	GJB2 GJB6	6.11e-05	10	35	2	EFO_0004530, EFO_0600007
Disease	Sensory hearing loss	GJB2 GJB3	7.47e-05	11	35	2	C1691779
Disease	Marfan Syndrome	LTBP2 FBN1	7.47e-05	11	35	2	C0024796
Disease	Cystic Fibrosis	SCNN1G TNFRSF1A	7.47e-05	11	35	2	C0010674
Disease	FEV/FEC ratio	GLIS3 CHRDL1 LTBP2 LTBP3 FBN1 MYRFL ZNF474 HMCN1	7.59e-05	1228	35	8	EFO_0004713
Disease	open-angle glaucoma	LTBP2 LTBP3 GLIS1 SVEP1	7.61e-05	191	35	4	EFO_0004190
Disease	Mitral valve prolapse, response to surgery	LTBP2 LTBP3	8.95e-05	12	35	2	EFO_0009951, HP_0001634
Disease	stenosing tenosynovitis	LTBP2 LTBP3	8.95e-05	12	35	2	EFO_0010822
Disease	Nonsyndromic genetic hearing loss	GJB2 GJB3 GJB6	1.01e-04	76	35	3	cv:C5680182
Disease	DEAFNESS, AUTOSOMAL RECESSIVE (disorder)	GJB2 GJB3	1.06e-04	13	35	2	C1846647
Disease	ischemia (implicated_via_orthology)	SCNN1G TNFRSF1A	1.84e-04	17	35	2	DOID:326 (implicated_via_orthology)
Disease	hearing impairment	GJB2 GJB3 GJB6	2.15e-04	98	35	3	C1384666
Disease	Deaf Mutism	GJB2 GJB3	2.56e-04	20	35	2	C4082305
Disease	Deafness, Acquired	GJB2 GJB3	2.56e-04	20	35	2	C0751068
Disease	Hearing Loss, Extreme	GJB2 GJB3	2.56e-04	20	35	2	C0086395
Disease	Complete Hearing Loss	GJB2 GJB3	2.56e-04	20	35	2	C0581883
Disease	Prelingual Deafness	GJB2 GJB3	2.56e-04	20	35	2	C0011052
Disease	Bilateral Deafness	GJB2 GJB3	2.56e-04	20	35	2	C3665473
Disease	intraocular pressure measurement	GLIS3 LTBP2 LTBP3 FBN1 ZNF474	3.17e-04	509	35	5	EFO_0004695
Disease	Deafness	GJB2 GJB3	4.03e-04	25	35	2	C0011053
Disease	suicidal ideation	LTBP2 LTBP3	5.44e-04	29	35	2	EFO_0004320
Disease	lung non-small cell carcinoma (is_implicated_in)	TNFRSF1A LRP1B EPAS1	6.00e-04	139	35	3	DOID:3908 (is_implicated_in)
Disease	body weight	CHRDL1 FNIP1 LTBP2 LTBP3 ZNF143 LRP1B EPAS1	6.02e-04	1261	35	7	EFO_0004338
Disease	Hereditary hearing loss and deafness	GJB2 GJB3 GJB6	6.92e-04	146	35	3	cv:C0236038
Disease	type 2 diabetes mellitus (biomarker_via_orthology)	FBN1 TNFRSF1A EPAS1	7.05e-04	147	35	3	DOID:9352 (biomarker_via_orthology)
Disease	glaucoma	LTBP2 LTBP3 LRP1B	8.07e-04	154	35	3	MONDO_0005041
Disease	Stevens-Johnson syndrome, toxic epidermal necrolysis, response to cold medicine	LTBP2 LTBP3	8.87e-04	37	35	2	EFO_0004276, EFO_0004775, EFO_0006997
Disease	COVID-19, mortality	LTBP2 LTBP3 LRP1B	1.07e-03	170	35	3	EFO_0004352, MONDO_0100096
Disease	hematocrit	GLIS3 ZNF462 CHRDL1 ZAN ITGB6 EPAS1	1.10e-03	1011	35	6	EFO_0004348
Disease	Autoimmune Diseases	TNFRSF1A ITGB6	1.14e-03	42	35	2	C0004364

Protein segments in the cluster

Peptide	Gene	Start	Entry
VYNNCPPHNSLCGYK	EPAS1	201	Q99814
NHCHCEKGYNPPYCQ	ADAM5	371	Q6NVV9
CPYGPSCYRKNPQHK	APLF	421	Q8IW19
SQCPPNLHKLDGYYC	ADAM11	521	O75078
PHGKNYTCRCPQGYQ	CD93	321	Q9NPY3
LQPGCKNVCYDHYFP	GJB2	56	P29033
VTAGNQPYCHCQPEY	LRP1B	4301	Q9NZR2
CAYAGPPQENCLLYQ	LAMA3	881	Q16787
YQLNYCSGQCPPHLA	INHBE	271	P58166
QCICHLSPYGNIYGP	ITGB6	521	P18564
CGSGNYNYNIPVNKH	MYRFL	791	Q96LU7
GRNCEQCKPFYYQHP	LAMB1	371	P07942
GSYQCICPPGYQLTH	HMCN1	5451	Q96RW7
PVCNACGLYYKLHNI	GATA3	336	P23771
HCPNRYPCKYPQKID	CHRDL1	301	Q9BU40
GKYQCACNPGYHSTP	FBN1	1176	P35555
PNCNCKYCSHPLLGQ	FNIP1	606	Q8TF40
LQPGCKNVCYDHFFP	GJB6	56	O95452
PYLCQHPGCQKAFSN	GLIS3	441	Q8NEA6
VCSPGYQLHPSQAYC	LTBP2	871	Q14767
CINFPGHYKCNCYPG	LTBP3	676	Q9NS15
PYLCQHPGCQKAFSN	GLIS1	291	Q8NBF1
KQPGCTNVCYDNYFP	GJB3	56	O75712
LPPAANYCNYQQHPN	SCNN1G	416	P51170
PYCGPNQIQHYLCDA	OR10G9	166	Q8NGN4
PGAYSSDPQCQNYCN	NTN5	336	Q8WTR8
NVQLYGTPKPCQYCN	FAM76A	61	Q8TAV0
CPRDYYQPNAGKAFC	SVEP1	1126	Q4LDE5
CICPPYRNISGHIYN	TMEM9	31	Q9P0T7
PYNCNHCGKTYKQIS	ZNF143	416	P52747
CPPYKENSGHIYNKN	TMEM9B	46	Q9NQ34
EKPYHCPACGRSFNQ	ZSCAN25	511	Q6NSZ9
PGAVYKCRHCPYINT	ZNF462	1511	Q96JM2
YKCQACGQTFQHPRY	ZNF57	196	Q68EA5
CKTHPYGPKYQNLNL	ZNF474	306	Q6S9Z5
KCHKGTYLYNDCPGP	TNFRSF1A	61	P19438
PYKCQQCGKAYSHPR	ZNF426	531	Q9BUY5
TVCQLKNGQYGCHPY	ZAN	1136	Q9Y493