Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	valine-tRNA ligase activity	VARS2 VARS1	3.46e-05	2	118	2	GO:0004832
GeneOntologyCellularComponent	distal axon	TSPOAP1 ADGRL1 DCC GPRIN1 SSH1 SYNJ1 KCNC2 COBL TRAK2 NOS1	1.57e-04	435	116	10	GO:0150034
Domain	ZnF_C2HC	FAM90A14 FAM90A1 FAM90A7 FAM90A9 FAM90A8	1.94e-05	55	112	5	SM00343
Domain	Znf_CCHC	FAM90A14 FAM90A1 FAM90A7 FAM90A9 FAM90A8	1.94e-05	55	112	5	IPR001878
Domain	Valyl-tRNA_ligase	VARS2 VARS1	3.56e-05	2	112	2	IPR002303
Domain	NYAP1/NYAP2	NYAP2 NYAP1	3.56e-05	2	112	2	IPR026722
Domain	NYAP_C	NYAP2 NYAP1	3.56e-05	2	112	2	IPR029353
Domain	NYAP_C	NYAP2 NYAP1	3.56e-05	2	112	2	PF15452
Domain	Anticodon_Ia_Val	VARS2 VARS1	3.56e-05	2	112	2	IPR033705
Domain	Protocadherin	PCDH11Y PCDH11X	3.52e-04	5	112	2	PF08374
Domain	Protocadherin	PCDH11Y PCDH11X	3.52e-04	5	112	2	IPR013585
Domain	Val/Leu/Ile-tRNA-synth_edit	VARS2 VARS1	5.26e-04	6	112	2	IPR009008
Domain	Anticodon_1	VARS2 VARS1	5.26e-04	6	112	2	PF08264
Domain	EF-hand_dom_typ1	DTNB UTRN	5.26e-04	6	112	2	IPR015153
Domain	EF-hand_dom_typ2	DTNB UTRN	5.26e-04	6	112	2	IPR015154
Domain	EF-hand_2	DTNB UTRN	5.26e-04	6	112	2	PF09068
Domain	EF-hand_3	DTNB UTRN	5.26e-04	6	112	2	PF09069
Domain	M/V/L/I-tRNA-synth_anticd-bd	VARS2 VARS1	5.26e-04	6	112	2	IPR013155
Domain	-	VARS2 VARS1	5.26e-04	6	112	2	3.90.740.10
Domain	aa-tRNA-synth_Ia	VARS2 VARS1	7.34e-04	7	112	2	IPR002300
Domain	tRNA-synt_1	VARS2 VARS1	7.34e-04	7	112	2	PF00133
Pubmed	Characterization and evolution of the novel gene family FAM90A in primates originated by multiple duplication and rearrangement events.	FAM90A14 FAM90A1 FAM90A17 FAM90A22 FAM90A23 FAM90A7 FAM90A9 FAM90A8 FAM90A16	1.25e-16	25	123	9	17684299
Pubmed	Analysis of the multi-copy gene family FAM90A as a copy number variant in different ethnic backgrounds.	FAM90A14 FAM90A17 FAM90A22 FAM90A23 FAM90A7 FAM90A9 FAM90A8 FAM90A16	9.11e-15	23	123	8	18602769
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SEMA4B ESYT1 PHF12 LAMA5 ADGRL1 SRCAP LYST LDLR CIC GAS2L1 KMT2D KLF10 SSH1 SYNJ1 GLI1 ZNF408 MCM3AP SEC16A COBL LTBP3 SNAPC4 SOWAHB	4.91e-11	1105	123	22	35748872
Pubmed	Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network.	FAM90A14 FAM90A1 FAM90A17 FAM90A22 FAM90A26 FAM90A23 FAM90A7 FAM90A9 FAM90A8	7.68e-09	164	123	9	22967998
Pubmed	Inflammation in atherosclerosis: lesion formation in LDL receptor-deficient mice with perforin and Lyst(beige) mutations.	LYST LDLR PRF1	1.72e-07	4	123	3	12171798
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	CUL3 PHF12 KDM5C IQCN GPRIN1 CIC KMT2D SSH1 CBFA2T2 BRPF1 SEC16A SNAPC4 AKAP1 KLHDC4	6.70e-07	774	123	14	15302935
Pubmed	Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defect.	LYST PRF1 IL21R	8.57e-07	6	123	3	38722309
Pubmed	Absence of alpha-syntrophin leads to structurally aberrant neuromuscular synapses deficient in utrophin.	DTNB NOS1 UTRN	6.98e-06	11	123	3	10995443
Pubmed	gamma-Syntrophin scaffolding is spatially and functionally distinct from that of the alpha/beta syntrophins.	DTNB NOS1 UTRN	6.98e-06	11	123	3	16857187
Pubmed	Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches.	KDM5C PCDH11Y PCDH11X	1.20e-05	13	123	3	14660691
Pubmed	NUTM2A-CIC fusion small round cell sarcoma: a genetically distinct variant of CIC-rearranged sarcoma.	NUTM2A CIC	1.24e-05	2	123	2	28188754
Pubmed	Conservation of PCDHX in mammals; expression of human X/Y genes predominantly in brain.	PCDH11Y PCDH11X	1.24e-05	2	123	2	11003707
Pubmed	Pcdh11x Negatively Regulates Dendritic Branching.	PCDH11Y PCDH11X	1.24e-05	2	123	2	25687328
Pubmed	Insights in cullin 3/WNK4 and its relationship to blood pressure regulation and electrolyte homeostasis.	CUL3 WNK4	1.24e-05	2	123	2	24518042
Pubmed	Cadherin expression delineates the divisions of the postnatal and adult mouse amygdala.	PCDH11Y PCDH11X	1.24e-05	2	123	2	22592879
Pubmed	Protocadherin X ( PCDHX) and Y ( PCDHY) genes; multiple mRNA isoforms encoding variant signal peptides and cytoplasmic domains.	PCDH11Y PCDH11X	1.24e-05	2	123	2	14727141
Pubmed	Subtle differences in CTL cytotoxicity determine susceptibility to hemophagocytic lymphohistiocytosis in mice and humans with Chediak-Higashi syndrome.	LYST PRF1	1.24e-05	2	123	2	21878672
Pubmed	Lack of association between protocadherin 11-X/Y (PCDH11X and PCDH11Y) polymorphisms and late onset Alzheimer's disease.	PCDH11Y PCDH11X	1.24e-05	2	123	2	21276771
Pubmed	Accelerated evolution of Protocadherin11X/Y: a candidate gene-pair for cerebral asymmetry and language.	PCDH11Y PCDH11X	1.24e-05	2	123	2	16874762
Pubmed	Participation of macrophages in atherosclerotic lesion morphology in LDLr-/- mice.	LYST LDLR	1.24e-05	2	123	2	15175354
Pubmed	PCDH11 is X/Y homologous in Homo sapiens but not in Gorilla gorilla and Pan troglodytes.	PCDH11Y PCDH11X	1.24e-05	2	123	2	16825765
Pubmed	The protocadherin 11X/Y (PCDH11X/Y) gene pair as determinant of cerebral asymmetry in modern Homo sapiens.	PCDH11Y PCDH11X	1.24e-05	2	123	2	23600975
Pubmed	Gli1 contributes to the invasiveness of pancreatic cancer through matrix metalloproteinase-9 activation.	GLI1 MMP9	1.24e-05	2	123	2	18410405
Pubmed	A comparative analysis of the pig, mouse, and human PCDHX genes.	PCDH11Y PCDH11X	1.24e-05	2	123	2	15112107
Pubmed	Protocadherin 11X/Y a human-specific gene pair: an immunohistochemical survey of fetal and adult brains.	PCDH11Y PCDH11X	1.24e-05	2	123	2	22744706
Pubmed	Quantitative analysis of alternative transcripts of human PCDH11X/Y genes.	PCDH11Y PCDH11X	1.24e-05	2	123	2	19859901
Pubmed	SEMA4b inhibits MMP9 to prevent metastasis of non-small cell lung cancer.	SEMA4B MMP9	1.24e-05	2	123	2	25095981
Pubmed	Genetically engineered mesenchymal stromal cells produce IL-3 and TPO to further improve human scaffold-based xenograft models.	THPO IL3	1.24e-05	2	123	2	28456746
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	PHF12 BCORL1 ZBTB9 CIC KMT2D SYNJ1 SEC16A AKAP1 UTRN	1.89e-05	418	123	9	34709266
Pubmed	An osteopontin-NADPH oxidase signaling cascade promotes pro-matrix metalloproteinase 9 activation in aortic mesenchymal cells.	LDLR MMP9	3.71e-05	3	123	2	16709900
Pubmed	Neuronal nitric oxide synthase-rescue of dystrophin/utrophin double knockout mice does not require nNOS localization to the cell membrane.	NOS1 UTRN	3.71e-05	3	123	2	22003386
Pubmed	Clinical presentation and outcome of pediatric patients with hemophagocytic lymphohistiocytosis in China: A retrospective multicenter study.	LYST PRF1	3.71e-05	3	123	2	27781387
Pubmed	Preliminary assessment of differential expression of candidate genes associated with atherosclerosis.	LDLR MMP9	3.71e-05	3	123	2	24025248
Pubmed	The alpha-syntrophin PH and PDZ domains scaffold acetylcholine receptors, utrophin, and neuronal nitric oxide synthase at the neuromuscular junction.	NOS1 UTRN	3.71e-05	3	123	2	20720107
Pubmed	Sarcolemmal nNOS anchoring reveals a qualitative difference between dystrophin and utrophin.	NOS1 UTRN	3.71e-05	3	123	2	20483958
Pubmed	Cadherin expression in the somatosensory cortex: evidence for a combinatorial molecular code at the single-cell level.	PCDH11Y PCDH11X	3.71e-05	3	123	2	21129452
Pubmed	Neuronal nitric oxide synthase localizes to utrophin expressing intercalated discs and stabilizes their structural integrity.	NOS1 UTRN	3.71e-05	3	123	2	26483274
Pubmed	Association of LDLR, TP53 and MMP9 Gene Polymorphisms With Atherosclerosis in a Malaysian Study Population.	LDLR MMP9	3.71e-05	3	123	2	36822563
Pubmed	Where and what is the right shift factor or cerebral dominance gene? A critique of Francks et al. (2007).	PCDH11Y PCDH11X	3.71e-05	3	123	2	19125366
Pubmed	Potent synergistic effect of IL-3 and TNF on matrix metalloproteinase 9 generation by human eosinophils.	MMP9 IL3	3.71e-05	3	123	2	22321809
Pubmed	Trigger-dependent differences determine therapeutic outcome in murine primary hemophagocytic lymphohistiocytosis.	LYST PRF1	3.71e-05	3	123	2	32419134
Pubmed	Estradiol-Induced MMP-9 Expression via PELP1-Mediated Membrane-Initiated Signaling in ERα-Positive Breast Cancer Cells.	PELP1 MMP9	3.71e-05	3	123	2	32037484
Pubmed	Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3.	CUL3 WNK4	3.71e-05	3	123	2	25250572
Pubmed	Non-clustered protocadherin.	PCDH11Y PCDH11X	3.71e-05	3	123	2	21173574
Pubmed	The chromosomal distribution of mouse odorant receptor genes.	UGT1A1 PRF1 GLI1 IL3	4.11e-05	54	123	4	8570653
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	KDM5C GPRIN1 NSUN7 RYR3 ZNF408 KIF19 COBL WNK4 ZNF292	7.21e-05	497	123	9	36774506
Pubmed	Involvement of selective autophagy mediated by p62/SQSTM1 in KLHL3-dependent WNK4 degradation.	CUL3 WNK4	7.41e-05	4	123	2	26349538
Pubmed	Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation.	CUL3 WNK4	7.41e-05	4	123	2	23665031
Pubmed	Pseudohypoaldosteronism Type II	CUL3 WNK4	7.41e-05	4	123	2	22073419
Pubmed	Wdpcp regulates cellular proliferation and differentiation in the developing limb via hedgehog signaling.	WDPCP GLI1	7.41e-05	4	123	2	34225660
Pubmed	Anti-Inflammatory Actions of Soluble Ninjurin-1 Ameliorate Atherosclerosis.	LDLR MMP9	7.41e-05	4	123	2	32883094
Pubmed	Inhibition of hypoxia inducible factor-1α attenuates abdominal aortic aneurysm progression through the down-regulation of matrix metalloproteinases.	LDLR MMP9	7.41e-05	4	123	2	27363580
Pubmed	Identification of novel candidate genes in heterotaxy syndrome patients with congenital heart diseases by whole exome sequencing.	KMT2D GLI1	7.41e-05	4	123	2	32738303
Pubmed	Cytokine production and function in c-mpl-deficient mice: no physiologic role for interleukin-3 in residual megakaryocyte and platelet production.	THPO IL3	7.41e-05	4	123	2	9531584
Pubmed	Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4.	CUL3 WNK4	7.41e-05	4	123	2	23576762
Pubmed	Biglycan regulates the expression and sarcolemmal localization of dystrobrevin, syntrophin, and nNOS.	DTNB NOS1	7.41e-05	4	123	2	16807372
Pubmed	Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension.	CUL3 WNK4	7.41e-05	4	123	2	23453970
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DCAF1 TSPOAP1 DDN ADGRL1 MCM3AP SEC16A COBL TRAK2	1.05e-04	407	123	8	12693553
Pubmed	Contribution of NK cells to the innate phase of host protection against an intracellular bacterium targeting systemic endothelium.	LYST PRF1	1.23e-04	5	123	2	22617213
Pubmed	Dp71 gene disruption alters the composition of the dystrophin-associated protein complex and neuronal nitric oxide synthase expression in the hypothalamic supraoptic and paraventricular nuclei.	NOS1 UTRN	1.23e-04	5	123	2	22493004
Pubmed	Blocking immunoinhibitory receptor LILRB2 reprograms tumor-associated myeloid cells and promotes antitumor immunity.	THPO IL3	1.23e-04	5	123	2	30352428
Pubmed	Decrease of WNK4 ubiquitination by disease-causing mutations of KLHL3 through different molecular mechanisms.	CUL3 WNK4	1.23e-04	5	123	2	23962426
Pubmed	IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation.	PRF1 IL21R	1.23e-04	5	123	2	19843883
Pubmed	Perforin is a critical physiologic regulator of T-cell activation.	LYST PRF1	1.23e-04	5	123	2	21606480
Pubmed	Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma.	NLGN3 MMP9	1.23e-04	5	123	2	28959975
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	DBF4B PHF12 LAMA5 ADGRL1 SLC22A17 NLGN3 COBL LTBP3 ADAMTSL4	1.77e-04	560	123	9	21653829
Pubmed	RNF220-mediated ubiquitination promotes aggresomal accumulation and autophagic degradation of cytoplasmic Gli via HDAC6.	RNF220 GLI1	1.84e-04	6	123	2	33895473
Pubmed	Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections.	THPO IL3	1.84e-04	6	123	2	30504915
Pubmed	iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases.	THPO IL3	1.84e-04	6	123	2	28426964
Pubmed	The fate and lifespan of human monocyte subsets in steady state and systemic inflammation.	THPO IL3	1.84e-04	6	123	2	28606987
Pubmed	inv(16) and NPM1mut AMLs engraft human cytokine knock-in mice.	THPO IL3	1.84e-04	6	123	2	27581357
Pubmed	Different dystrophin-like complexes are expressed in neurons and glia.	DTNB UTRN	1.84e-04	6	123	2	10545507
Pubmed	Protocadherin 11 x regulates differentiation and proliferation of neural stem cell in vitro and in vivo.	PCDH11Y PCDH11X	1.84e-04	6	123	2	24647733
Pubmed	Development and function of human innate immune cells in a humanized mouse model.	THPO IL3	1.84e-04	6	123	2	24633240
Pubmed	IL-36γ Transforms the Tumor Microenvironment and Promotes Type 1 Lymphocyte-Mediated Antitumor Immune Responses.	IL1RL2 PRF1	1.84e-04	6	123	2	26321222
Pubmed	A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies.	THPO IL3	1.84e-04	6	123	2	30664659
Pubmed	Microenvironment-dependent growth of preneoplastic and malignant plasma cells in humanized mice.	THPO IL3	2.58e-04	7	123	2	27723723
Pubmed	Matrix Metalloproteinase-9 gene induction by a truncated oncogenic NF-kappaB2 protein involves the recruitment of MLL1 and MLL2 H3K4 histone methyltransferase complexes.	KMT2D MMP9	2.58e-04	7	123	2	19219072
Pubmed	Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes.	THPO MMP9	2.58e-04	7	123	2	16648859
Pubmed	Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease.	THPO IL3	2.58e-04	7	123	2	33097708
Pubmed	Targeting Cbx3/HP1γ Induces LEF-1 and IL-21R to Promote Tumor-Infiltrating CD8 T-Cell Persistence.	PRF1 IL21R	2.58e-04	7	123	2	34721405
Pubmed	Humanized mice in translational biomedical research.	LYST PRF1	2.58e-04	7	123	2	17259968
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	KDM5C ZBTB9 E4F1 CIC GLI1 CBFA2T2 ZNF408 BRPF1 PLAGL2 SNAPC4 ZNF292	2.93e-04	877	123	11	20211142
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	PHF12 BCORL1 ZBTB9 SRCAP CIC RNF220 BRPF1 SNAPC4 ZNF292	3.24e-04	608	123	9	36089195
Pubmed	DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy.	DCAF1 MYCT1 FAM90A1 NSUN7 RUSC1-AS1 KLHDC4 ADAMTSL4	3.26e-04	364	123	7	31391242
Pubmed	Molecular genetic markers spanning mouse chromosome 10.	PRF1 GLI1	3.43e-04	8	123	2	1981053
Pubmed	The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.	CUL3 WNK4	3.43e-04	8	123	2	23387299
Pubmed	KLHL2 interacts with and ubiquitinates WNK kinases.	CUL3 WNK4	3.43e-04	8	123	2	23838290
Pubmed	Suppression of IL-1β promotes beneficial accumulation of fibroblast-like cells in atherosclerotic plaques in clonal hematopoiesis.	LDLR GLI1	3.43e-04	8	123	2	38362011
Pubmed	L-arginine decreases inflammation and modulates the nuclear factor-kappaB/matrix metalloproteinase cascade in mdx muscle fibers.	MMP9 UTRN	3.43e-04	8	123	2	18458097
Pubmed	Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia.	CUL3 WNK4	3.43e-04	8	123	2	26286618
Pubmed	Gelatinase B (MMP-9) is not essential in the normal kidney and does not influence progression of renal disease in a mouse model of Alport syndrome.	LAMA5 MMP9	4.39e-04	9	123	2	10880400
Pubmed	Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation.	CUL3 GLI1	4.39e-04	9	123	2	20081843
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	LAMA5 MCM3AP TRAK2 ZNF292	5.41e-04	105	123	4	9628581
Pubmed	The IL-6 signaling complex is a critical driver, negative prognostic factor, and therapeutic target in diffuse large B-cell lymphoma.	THPO IL3	5.48e-04	10	123	2	31515941
Pubmed	Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells.	LYST PRF1	5.48e-04	10	123	2	17982459
Pubmed	Immune effectors required for hepatitis B virus clearance.	LYST PRF1	5.48e-04	10	123	2	20080755
Pubmed	Loss of Fam60a, a Sin3a subunit, results in embryonic lethality and is associated with aberrant methylation at a subset of gene promoters.	LENG9 ADHFE1	6.68e-04	11	123	2	30070635
Pubmed	The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability.	CUL3 GLI1	6.68e-04	11	123	2	27621083
Pubmed	delta-Protocadherins: a gene family expressed differentially in the mouse brain.	PCDH11Y PCDH11X	6.68e-04	11	123	2	15905963
Interaction	TOP3B interactions	SEMA4B ESYT1 PHF12 LAMA5 ADGRL1 SRCAP LYST LDLR CIC GAS2L1 KMT2D KLF10 SSH1 PELP1 SYNJ1 GLI1 ZNF408 MCM3AP SEC16A COBL LTBP3 SNAPC4 ADAMTSL4 SOWAHB	1.19e-06	1470	111	24	int:TOP3B
Interaction	H3-3A interactions	DCAF1 CUL3 DYNC2I2 KDM5C BCORL1 ZBTB9 SRCAP CIC RNF220 KMT2D PELP1 BRPF1 SNAPC4 VARS1 ZNF292	1.53e-05	749	111	15	int:H3-3A
Interaction	LHX6 interactions	KDM5C BCORL1 ZBTB9 FAM90A1 CIC	1.68e-05	58	111	5	int:LHX6
Interaction	FAM90A26 interactions	FAM90A1 FAM90A26	3.01e-05	2	111	2	int:FAM90A26
Cytoband	8p23.1	FAM90A14 FAM90A17 FAM90A22 FAM90A23 FAM90A7 FAM90A9 FAM90A8 FAM90A16	9.92e-09	154	123	8	8p23.1
Cytoband	Ensembl 112 genes in cytogenetic band chr8p23	FAM90A14 FAM90A17 FAM90A22 FAM90A23 FAM90A7 FAM90A9 FAM90A8 FAM90A16	2.51e-07	234	123	8	chr8p23
GeneFamily	PHD finger proteins	PHF12 KDM5C KMT2D BRPF1	4.81e-04	90	73	4	88
GeneFamily	Non-clustered protocadherins	PCDH11Y PCDH11X	1.03e-03	12	73	2	21
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	DTNB UTRN	2.36e-03	18	73	2	91
GeneFamily	Aminoacyl tRNA synthetases, Class I	VARS2 VARS1	2.63e-03	19	73	2	131
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	LMNTD2 LDLR PCDH11X COBL LTBP3 UTRN SLC22A31	8.64e-07	197	116	7	3d13a4f2e86422900ee2194e8a1fd1cf9750d5d3
ToppCell	Frontal_cortex-Neuronal\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	ADGRL1 IDS GPRIN1 RNF220 SYNJ1 LONRF2 NYAP1	9.24e-07	199	116	7	f88039d862f3bfa01dc39d2de4f3f548dc5a0e61
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DTNB LDLR COBL LONRF2 KLHDC4 SLC22A31	8.02e-06	181	116	6	576da14ab3107f89e1f44a4a439d1bef5bb42370
ToppCell	Substantia_nigra-Neuronal\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	NYAP2 GPRIN1 SYNJ1 TTLL11 LONRF2 NYAP1	9.37e-06	186	116	6	3f889083fcffe516388e9b03a5e23af2010ced33
ToppCell	cellseq2-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-VEC\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	INTS6L MYCT1 SRCAP LDLR SNAPC4 ADAMTSL4	1.03e-05	189	116	6	bccb3481ffed597c845fe860da658505316105b5
ToppCell	Hippocampus-Neuronal\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ADGRL1 IDS RNF220 SYNJ1 TTLL11 NYAP1	1.19e-05	194	116	6	8aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	KIF6 LMNTD2 PCDH11X COBL UTRN SLC22A31	1.30e-05	197	116	6	b94645d57efe8d9e032bffb8c89af1f425c6421e
ToppCell	LPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_only / Treatment groups by lineage, cell group, cell type	LMNTD2 LDLR COBL LTBP3 UTRN SLC22A31	1.41e-05	200	116	6	2dadf317a42a7e27cc1fac74f91b806c93a57108
ToppCell	Control_saline-Epithelial_alveolar-AT_1-Differentiating_AT2\|Control_saline / Treatment groups by lineage, cell group, cell type	DBF4B TMCO4 PCDH11X COBL SNAPC4 SLC22A31	1.41e-05	200	116	6	eac33be484dc443794e66e473f03e98406c2983e
Disease	cognitive function measurement	CUL3 NYAP2 ARPP21 TCERG1L DBF4B ZBTB9 DDN DCC WDPCP RYR3 MEI4 KMT2D KCNC2 TTLL11 GJD3 MTRFR LONRF2 SOWAHB REV1	9.05e-07	1434	107	19	EFO_0008354
Disease	combined oxidative phosphorylation deficiency 20 (implicated_via_orthology)	VARS2 VARS1	1.30e-05	2	107	2	DOID:0111478 (implicated_via_orthology)
Disease	multiple sclerosis (is_marker_for)	PRF1 GLI1 IL21R MMP9	3.05e-05	49	107	4	DOID:2377 (is_marker_for)
Disease	Pseudohypoaldosteronism type 2A	CUL3 WNK4	7.78e-05	4	107	2	cv:C1840389
Disease	Pseudohypoaldosteronism, type 2	CUL3 WNK4	7.78e-05	4	107	2	cv:C1449844
Disease	Crohn's disease (is_implicated_in)	UGT1A1 PRF1 IL21R	1.75e-04	30	107	3	DOID:8778 (is_implicated_in)
Disease	myoclonic-atonic epilepsy (implicated_via_orthology)	VARS2 VARS1	2.70e-04	7	107	2	DOID:0060475 (implicated_via_orthology)
Disease	Morphine Abuse	MMP9 NOS1	2.70e-04	7	107	2	C0600272
Disease	Morphine Dependence	MMP9 NOS1	2.70e-04	7	107	2	C0026552
Disease	mitochondrial encephalomyopathy (implicated_via_orthology)	VARS2 VARS1	3.60e-04	8	107	2	DOID:890 (implicated_via_orthology)
Disease	pseudohypoaldosteronism (is_implicated_in)	CUL3 WNK4	3.60e-04	8	107	2	DOID:4479 (is_implicated_in)
Disease	dietary approaches to stop hypertension diet	ARPP21 DDN	4.61e-04	9	107	2	EFO_0803365
Disease	age at first sexual intercourse measurement	CUL3 ARPP21 BCORL1 DCC TTLL11 UTRN ZNF292	5.04e-04	383	107	7	EFO_0009749
Disease	lymphocyte:monocyte ratio	NEK6 TSPOAP1 VARS2 LYST PRF1 VARS1	6.50e-04	288	107	6	EFO_0600088
Disease	intracranial aneurysm (is_implicated_in)	KMT2D MMP9	8.40e-04	12	107	2	DOID:10941 (is_implicated_in)
Disease	aplastic anemia (is_implicated_in)	THPO PRF1	9.90e-04	13	107	2	DOID:12449 (is_implicated_in)
Disease	cortisol measurement, response to corticosteroid, response to synacthen	ELSPBP1 NOS1	9.90e-04	13	107	2	EFO_0005843, EFO_0009175, GO_0031960
Disease	free cholesterol to total lipids in large HDL percentage	NYAP2 LDLR MMP9	1.12e-03	56	107	3	EFO_0022279
Disease	free cholesterol in very large HDL measurement	NYAP2 LDLR MMP9	1.50e-03	62	107	3	EFO_0022273
Disease	syndromic intellectual disability (implicated_via_orthology)	KDM5C BRPF1	1.51e-03	16	107	2	DOID:0050888 (implicated_via_orthology)
Disease	temporal arteritis (is_implicated_in)	IL21R MMP9	1.51e-03	16	107	2	DOID:13375 (is_implicated_in)
Disease	ocular hypertension (biomarker_via_orthology)	GLI1 MMP9	1.71e-03	17	107	2	DOID:9282 (biomarker_via_orthology)
Disease	age at initiation of smoking	CUL3 WDPCP VARS1	1.80e-03	66	107	3	EFO_0021784
Disease	hair colour measurement	NYAP2 NEK6 LYST WDPCP KMT2D AKAP1 KLHDC4 SLC22A31	1.82e-03	615	107	8	EFO_0007822
Disease	Non-alcoholic Fatty Liver Disease	LDLR PRF1 IL3	2.13e-03	70	107	3	C0400966
Disease	Nonalcoholic Steatohepatitis	LDLR PRF1 IL3	2.13e-03	70	107	3	C3241937
Disease	X-11470 measurement	VARS2 VARS1	2.14e-03	19	107	2	EFO_0021241
Disease	multiple sclerosis (is_implicated_in)	PRF1 IL21R MMP9	2.40e-03	73	107	3	DOID:2377 (is_implicated_in)
Disease	granulocyte percentage of myeloid white cells	NYAP2 NEK6 TSPOAP1 SNAPC4 ZNF292	2.98e-03	268	107	5	EFO_0007997
Disease	squamous cell lung carcinoma	NYAP2 VARS2 COBL VARS1	3.11e-03	165	107	4	EFO_0000708
Disease	Attention deficit hyperactivity disorder	CIC ZNF292	3.41e-03	24	107	2	C1263846

Protein segments in the cluster

Peptide	Gene	Start	Entry
PATHSLPPSNPCRLT	LINC00114	56	Q6XXX2
PPRPCHTTPDSQFGT	ESYT1	631	Q9BSJ8
EPPALLQTHPPCRRS	AKAP1	91	Q92667
NVTSPSNCSHLPRPP	ADAMTSL4	946	Q6UY14
RPPAPNLHVSPELFC	ADGRL1	466	O94910
LVTTNFSPLPAPICP	BCORL1	191	Q5H9F3
ATAAPCAPHPAPRSR	DDN	351	O94850
PRGRFVHVPPQLPCS	CYB5D1	96	Q6P9G0
NLRLIGPHCPSSTVP	ARPP21	776	Q9UBL0
RPFTPIHSCIISPSL	CCDC60	131	Q8IWA6
ASLPARVSCPSPHPS	TSPOAP1	1081	O95153
RVSCPSPHPSPEARA	TSPOAP1	1086	O95153
AFLPHQTVTIRFPCP	IQCN	236	Q9H0B3
SLPPRTSHPVVRFSC	INTS6L	301	Q5JSJ4
VPSVDRQPPHSTPCL	FAM90A7	356	A6NKC0
RQPPHSTPCLPTAQA	FAM90A7	361	A6NKC0
VPSVDRQPPHSRPCL	FAM90A23	356	A8MXZ1
RQPPHSRPCLPTAQA	FAM90A23	361	A8MXZ1
TVCPTGPPTVHPSER	MMP9	466	P14780
NPVATCPPFSLFTPH	DCAF1	1021	Q9Y4B6
PSPTCGYPHPQFTLR	DCC	1266	P43146
VQTPSTLHLPFCPDR	OR2H2	156	O95918
HIPPAPQASSPTFCK	KCNC2	496	Q96PR1
RQPPHSRPCLPTAQA	FAM90A1	361	Q86YD7
LPPVPRHTPVCSFNS	MCM3AP	971	O60318
VPSAVLCLAFHPTQP	DYNC2I2	216	Q96EX3
VPSVDRQPPHSRPCL	FAM90A22	356	A8MWA6
RQPPHSRPCLPTAQA	FAM90A22	361	A8MWA6
VPSVDRQPPHSRPCL	FAM90A14	356	P0C7W9
RQPPHSRPCLPTAQA	FAM90A14	361	P0C7W9
CTISPAPRHSPALTV	CBFA2T2	261	O43439
SVAAPCQPRPTHFVA	LENG9	311	Q96B70
PLPVPAPCHTAARSE	PRF1	16	P14222
PPDPQRHPNTLSFRC	NEK6	26	Q9HC98
VNARKILPSPCPSPH	KIF6	746	Q6ZMV9
PHPQSRGPFPTCQLK	GLI1	166	P08151
LPDTTPHPAPVVCSA	LMNTD2	36	Q8IXW0
FVCEPPVVTHRSPPL	LRFN3	291	Q9BTN0
AFPTVPCPLHVFEPR	LONRF2	546	Q1L5Z9
PRSTPPHPCSLEDNV	PMS2P1	411	A4D2B8
VPSVDRQPPHSTPCL	FAM90A17	356	P0DV74
RQPPHSTPCLPTAQA	FAM90A17	361	P0DV74
PTEQLSPSHPPLITC	LAMA5	1076	O15230
LLVFPPAPVHCSPNS	NYAP2	336	Q9P242
SPRVTQTIALCHSPP	PCDH11X	1186	Q9BZA7
TCAALTHPRVPPLQP	PELP1	626	Q8IZL8
VPSVDRQPPHSTPCL	FAM90A16	356	P0DV73
RQPPHSTPCLPTAQA	FAM90A16	361	P0DV73
APSFHLPRNPQVPCI	NOS1	1236	P29475
TGNPTPHFLSVCRPN	PLPPR2	151	Q96GM1
PLACKRPPSPTLQHA	KIF19	826	Q2TAC6
PIQRPIPSAFCFLSH	NEU2	186	Q9Y3R4
RLVSHTVPRAPPSPC	PODNL1	486	Q6PEZ8
VPSIDRQPPHSTPCL	FAM90A8	356	A6NJQ4
RQPPHSTPCLPTAQA	FAM90A8	361	A6NJQ4
CRPFPPVQLLQHTPC	IL1RL2	541	Q9HB29
HFPPVCPQNIHTAVP	NLGN3	101	Q9NZ94
SFPDNLPPSCPTHRH	WDPCP	666	O95876
LPCLPLATAAPTRHP	IL3	101	P08700
PIPRTSHPCTLAFPS	DBF4B	566	Q8NFT6
HRPPQPRVCTFSPQR	GAS2L1	281	Q99501
QSATPKCNIPPAPRH	CUL3	516	Q13618
PPPPHTSDTQACSRE	COBL	1021	O75128
SLGCVPTREPPHPVF	DTNB	306	O60941
PPCPHTVDCFVSRPT	GJD3	171	Q8N144
PSAPVPVVCFSQPHG	LYST	3476	Q99698
SHPRPPTQKPLGRCF	LTBP3	266	Q9NS15
TRISALVPGFPCHFP	ELSPBP1	171	Q96BH3
DIPSPPPRRCAHQAV	KLHDC4	111	Q8TBB5
TPDFHTIPAFCLTPP	KLF10	81	Q13118
PSTLEVYSCHPPRSP	IL21R	311	Q9HBE5
VPRTHPCPQCSETFP	E4F1	431	Q66K89
LQVPPRCPVPSFHVE	IDS	416	P22304
CPSQQKASPAPPRHT	GPRIN1	46	Q7Z2K8
VPSVDRQPPHSRPCL	FAM90A5P	356	A8MXJ8
RQPPHSRPCLPTAQA	FAM90A5P	361	A8MXJ8
LLTAQPAPHCRPDPT	SLC22A31	41	A6NKX4
RTPTCRELGSPHPTP	SCNN1D	36	P51172
VPSVDRQPPHSRPCL	FAM90A24P	356	P0C7X0
RQPPHSRPCLPTAQA	FAM90A24P	361	P0C7X0
SPPVTQTIALCHSPP	PCDH11Y	1191	Q9BZA8
YHLRSPCPSNPITRP	ADHFE1	256	Q8IWW8
PCSQPRDALSQPHPA	NYAP1	746	Q6ZVC0
AARPTSPPQDHRPTC	NUTM2A	711	Q8IVF1
AARPTSPPQDHRPTC	NUTM2E	711	B1AL46
FVESCTPTHFPPLPL	MEI4	121	A8MW99
AHPRICLQPPPTSRT	VARS1	36	P26640
HSPRPLGPPQVLFSC	VARS2	831	Q5ST30
VPRPHQVSRCPQPLF	HHLA1	431	C9JL84
HSTFPSCCPNVPSRP	UTRN	3416	P46939
PVTVQPPHCVPDTYS	TMEM248	196	Q9NWD8
FINICHSPSIPPPAD	PIH1D1	66	Q9NWS0
LPAAASPERPPICSH	TMCO4	596	Q5TGY1
TNVSFCVLPSRRPPP	SYNJ1	1526	O43426
PPTRCDHVPLLATPN	SLC22A17	521	Q8WUG5
TFHPFLQCPPLPVET	MYCT1	166	Q8N699
PHPAVPAFVKNTCPS	NSUN7	611	Q8NE18
VPSVDRQPPHSRPCL	FAM90A12P	356	A8MX19
RQPPHSRPCLPTAQA	FAM90A12P	361	A8MX19
VPSVDRQPPHSTPCL	FAM90A9	356	A6NNJ1
RQPPHSTPCLPTAQA	FAM90A9	361	A6NNJ1
VPSVDRQPPHSRPCL	FAM90A13P	356	P0C7W8
RQPPHSRPCLPTAQA	FAM90A13P	361	P0C7W8
RQPPHSRPCLPTAQA	FAM90A26	361	D6RGX4
SSCPQRSLVPVPSLP	PHF12	611	Q96QT6
TVTHPVPTPRPGACI	SEMA4B	386	Q9NPR2
LKCPATQPHVVFPPS	SPATA31E1	231	Q6ZUB1
CSTVHCFIPPRPPIF	PRR32	241	B1ATL7
HPQFAPPNLDCTPIS	RNF220	96	Q5VTB9
SPAPLSCPAPRAQVH	RUSC1-AS1	141	Q66K80
TPAHLVPQPCPRLVF	SEC31B	406	Q9NQW1
CNHPNLFDPRPVTSP	SRCAP	901	Q6ZRS2
HTPPPAQTCLVTPSS	SRCAP	2511	Q6ZRS2
PPDPCLSSHSLFPVV	SOWAHB	351	A6NEL2
VPSVDRQPPHSRPCL	FAM90A15P	356	P0C7V4
RQPPHSRPCLPTAQA	FAM90A15P	361	P0C7V4
RPHSLPQPEQRPYSC	PLAGL2	56	Q9UPG8
PNAPAICTQPAFLPH	SSH1	671	Q8WYL5
ICTQPAFLPHITSSP	SSH1	676	Q8WYL5
AAAPVVSVPCIPPHR	BRPF1	506	P55201
SPVIRSSFTHCRPPL	CIC	496	Q96RK0
PVFPHLCPSALATPI	TCERG1L	136	Q5VWI1
TPLCLPQPAHRFPFG	PRSS53	141	Q2L4Q9
PNCSSSRIPTVPRPH	SWI5	96	Q1ZZU3
CPSPLPFEPRVHLSE	TRAK2	786	O60296
NPPPRTSCANKLSHP	TTLL11	781	Q8NHH1
LFHFPTPLTRICPAP	MTRFR	6	Q9H3J6
VPCATSVPHFPTPSI	SEC16A	241	O15027
RTCTFLPPFPAHLPT	REV1	886	Q9UBZ9
PCPVDTSQVILPPHL	RYR3	851	Q15413
QLSHRPEAPCSPPSV	ZNF408	626	Q9H9D4
CPNPFSYVPRPLSSH	UGT1A1	186	P22309
PTVPPLLHTVCHPNT	ZNF292	1531	O60281
PASPTCNPAPRTIQI	ZBTB9	11	Q96C00
IHTIPNCSFSPPLRP	TRIM49D1	431	C9J1S8
PSCRTDTPAPPTHAL	SNAPC4	1146	Q5SXM2
LPVATTTAQPTFPCP	ZNF576	101	Q9H609
CHPSPSPFSPISSQV	WNK4	836	Q96J92
EGHSPSCRTFVPLPP	XRRA1	511	Q6P2D8
PPRHPSCDSFSLEPL	VWA5B1	1111	Q5TIE3
RLSQCPEVHPLPTPV	THPO	46	P40225
STLTPRLHLPCPQQP	KDM5C	1541	P41229
VAEQHTPVCSRFSPP	KMT2D	361	O14686
HQPSTPDPFLKPRCP	KMT2D	2236	O14686
GRHPSPCQFTIATPK	KMT2D	3126	O14686
CLPAPQINPHSPKFT	LDLR	681	P01130