Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentcleavage furrow

OR2A7 HMCN2 OR2A4 RACGAP1

7.19e-0561764GO:0032154
GeneOntologyCellularComponentmitotic spindle

OR2A7 MAP1S OR2A4 RACGAP1 MAPKBP1 DCTN1

9.16e-05201766GO:0072686
GeneOntologyCellularComponentplatelet dense granule membrane

ABCC4 ITPR1

1.94e-046762GO:0031088
GeneOntologyCellularComponentcell division site

OR2A7 HMCN2 OR2A4 RACGAP1

2.07e-0480764GO:0032153
GeneOntologyCellularComponentFlemming body

OR2A7 OR2A4 RACGAP1

3.02e-0436763GO:0090543
GeneOntologyCellularComponentspindle midzone

OR2A7 OR2A4 RACGAP1

4.14e-0440763GO:0051233
GeneOntologyCellularComponentmitotic spindle pole

OR2A7 OR2A4 MAPKBP1

5.13e-0443763GO:0097431
GeneOntologyCellularComponentspindle pole

OR2A7 CEP89 OR2A4 MAPKBP1 DCTN1

9.08e-04205765GO:0000922
GeneOntologyCellularComponentrecycling endosome

OR2A7 MCTP1 MICALL2 OR2A4 RAB11FIP5

1.29e-03222765GO:0055037
GeneOntologyCellularComponentmitotic spindle midzone

OR2A7 OR2A4

1.51e-0316762GO:1990023
GeneOntologyCellularComponentspindle

OR2A7 MAP1S CEP89 OR2A4 RACGAP1 MAPKBP1 DCTN1

1.62e-03471767GO:0005819
Domain-

MAP1S DCLRE1A ELAC2

6.48e-05207433.60.15.10
DomainMetallo-B-lactamas

MAP1S DCLRE1A ELAC2

6.48e-0520743IPR001279
DomainCoact_PPARg

FAM120A FAM120C

9.24e-054742IPR026784
DomainRap_GAP

RALGAPA1 RAP1GAP2

6.83e-0410742PF02145
DomainRap_GAP_dom

RALGAPA1 RAP1GAP2

8.32e-0411742IPR000331
DomainRAPGAP

RALGAPA1 RAP1GAP2

8.32e-0411742PS50085
DomainPIN_domain-like

FAM120A FAM120C

1.37e-0314742IPR029060
DomainLactamase_B

DCLRE1A ELAC2

1.57e-0315742SM00849
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

JUN NR2F6 FASN KMT2D BRD2 MAP1S NUAK1 OBSCN PSMB10 RAP1GAP2 MAPKBP1 IL17RD DCTN1 ELAC2 CRAMP1 WNK2

2.62e-091105781635748872
Pubmed

The human gene CXorf17 encodes a member of a novel family of putative transmembrane proteins: cDNA cloning and characterization of CXorf17 and its mouse ortholog orf34.

FAM120A FAM120C FAM120AOS

4.33e-08478314585507
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

RALGAPA1 EXOSC10 FAM120A BRD2 SEC24C GTF3C2 CEP89 BAZ2A RAB11FIP5 CMAS DCTN1 ELAC2 MPP7 NDUFV2 ITPR1

9.39e-071487781533957083
Pubmed

Quantitative trait loci for body size components in mice.

TRMT2A BRD2 CIITA CMAS ITPR1

2.87e-069878516783635
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

RALGAPA1 MAST4 GTF3C2 NUAK1 RACGAP1 RAB11FIP5 NPEPL1 CRAMP1 WNK2

2.93e-0652978914621295
Pubmed

The actin and Rho-modifying toxins PTC3 and PTC5 of Photorhabdus luminescens: enzyme characterization and induction of MAL/SRF-dependent transcription.

JUN MRTFA

4.97e-06278225338512
Pubmed

A genome-wide association study of body mass index across early life and childhood.

FAM120A FAM120AOS

4.97e-06278225953783
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

JUN NR2F6 FASN KMT2D BRD2 SEC24C MAP1S BAZ2A RREB1 MRTFA

9.05e-06774781015302935
Pubmed

Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect epidermal proliferation and differentiation.

OR2A7 OR2A4

1.49e-05378227315375
Pubmed

Functional characterization of the mouse melanocortin 3 receptor gene promoter.

JUN MC3R

1.49e-05378225701401
Pubmed

A zonal organization of odorant receptor gene expression in the olfactory epithelium.

OR2A7 OR2A4

2.97e-0547827683976
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

JUN EXOSC10 KMT2D BRD2 GTF3C2 BAZ2A TONSL RACGAP1 SRSF11 DCLRE1A RREB1 CMAS

3.01e-051294781230804502
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

FAM120A MCTP1 HMCN2 TRMT2A BRD2 BAZ2A FAM120C RAB11FIP5 RREB1 CMAS CDH16

3.85e-051116781131753913
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

TSHZ3 FASN KMT2D GTF3C2 RREB1 DCTN1 MRTFA

4.37e-0541878734709266
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

FASN EXOSC10 BRD2 SEC24C FAM120C RACGAP1 SRSF11 DCTN1

4.92e-0558278820467437
Pubmed

The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.

JUN TRMT2A SEC24C GTF3C2 BAZ2A TONSL RREB1 CMAS

4.98e-0558378829844126
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

TSHZ3 FMO1 MAP1S AP5B1 TONSL WNK2 MRTFA

5.22e-0543078735044719
Pubmed

Intron 1-Mediated Regulation of EGFR Expression in EGFR-Dependent Malignancies Is Mediated by AP-1 and BET Proteins.

JUN BRD2

7.40e-05678231444232
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

RALGAPA1 FASN FAM120A SEC24C MAP1S FAM120C LZTS1 CMAS DCTN1 TNS1 WNK2 NDUFV2

7.91e-051431781237142655
Pubmed

STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production.

JUN EXOSC10 GTF3C2 CIITA OBSCN SRSF11

7.96e-0531678631665637
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

PPP4R1 FAM120A TRMT2A AP5B1 TONSL RACGAP1 SRSF11 ITPR1

1.06e-0465078838777146
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

JUN NR2F6 FASN KMT2D FAM120A TRMT2A GTF3C2 DCTN1 NDUFV2

1.28e-0485778925609649
Pubmed

Saturation mutagenesis defines novel mouse models of severe spine deformity.

OR2A7 OR2A4

1.38e-04878234142127
Pubmed

Identification of proteins that interact with alpha A-crystallin using a human proteome microarray.

FASN SEC24C ZIM2 MAPKBP1

1.48e-0411878424453475
Pubmed

Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.

FASN TONSL OBSCN SRSF11 CRAMP1

1.59e-0422678531452512
Pubmed

CLAC-P/collagen type XXV is required for the intramuscular innervation of motoneurons during neuromuscular development.

JUN COL25A1

2.21e-041078224453327
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

RALGAPA1 FASN EXOSC10 TRMT2A BRD2 SEC24C RACGAP1 SRSF11 CMAS

3.69e-0498978936424410
Pubmed

Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

ADAMTS19 TSHZ3 ABCC4 BRD2 AP5B1 TONSL OBSCN SRSF11 IL17RD ITPR1

3.80e-041215781015146197
Pubmed

Evolution of odorant receptors expressed in mammalian testes.

OR2A7 OR2A4

3.81e-041378211014824
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

TSHZ3 BRD2 GTF3C2 BAZ2A RACGAP1 RREB1 CMAS

4.36e-0460878736089195
Pubmed

Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb.

OR2A7 OR2A4

4.44e-04147827528109
Pubmed

Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases.

MAP1S CIITA

4.44e-041478215964851
Pubmed

Coordinated histone modifications mediated by a CtBP co-repressor complex.

RREB1 ELAC2

5.12e-041578212700765
Pubmed

A genome annotation-driven approach to cloning the human ORFeome.

CYP2D6 TRMT2A ENTHD1 C22orf15 MRTFA

5.32e-0429478515461802
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

RALGAPA1 PPP4R1 KMT2D BRD2 CEP89 RAB11FIP5 TNS1 MPP7 ITPR1

5.65e-04104978927880917
Pubmed

Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain.

JUN OLIG1

5.84e-041678230322923
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

KMT2D FAM120A BRD2 GTF3C2 ZNF831 CMAS

6.59e-0446978627634302
Pubmed

EML3 is a nuclear microtubule-binding protein required for the correct alignment of chromosomes in metaphase.

MAP1S RACGAP1

8.28e-041978218445686
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

FASN EXOSC10 FAM120A SEC24C GTF3C2 BAZ2A RACGAP1 CMAS DCTN1 ELAC2

8.74e-041353781029467282
Pubmed

A comprehensive resource of interacting protein regions for refining human transcription factor networks.

JUN NR2F6 SRSF11 DCTN1

9.16e-0419178420195357
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

FASN EXOSC10 GTF3C2 RREB1 ELAC2

9.18e-0433278532786267
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

TRMT2A BRD2 MAP1S NUAK1 CMAS RETSAT DCTN1 TNS1

9.93e-0491078836736316
Pubmed

Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.

KMT2D KDM8

1.01e-032178227626377
Pubmed

The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.

JUN EXOSC10 FAM120A BAZ2A RREB1

1.15e-0334978525665578
Pubmed

Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.

RALGAPA1 BRD2 GTF3C2 RAB11FIP5 MPP7 NDUFV2

1.27e-0353378625544563
Pubmed

TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.

FASN FAM120A TRMT2A RACGAP1 RAB11FIP5 CMAS DCTN1 ITPR1

1.30e-0394978836574265
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

JUN EXOSC10 BRD2 BAZ2A RACGAP1 SRSF11 RREB1 NDUFV2

1.34e-0395478836373674
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

FAM120A SEC24C FAM120C LZTS1 RACGAP1 DCTN1 TNS1 WNK2

1.42e-0396378828671696
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

FASN EXOSC10 KMT2D GTF3C2 BAZ2A DCTN1

1.48e-0354978638280479
Pubmed

Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.

KMT2D OR2A4 DACT2 IL17RD TNS1 ITPR1

1.52e-0355278610737800
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

FASN SEC24C DACT2 KDM8 DCTN1 MRTFA ITPR1

1.53e-0375478735906200
Pubmed

SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.

DPP7 ABCC4 BRD2 MRTFA MPP7

1.63e-0337878534315543
Pubmed

NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.

TSHZ3 BRD2 BAZ2A

1.63e-0310378332744500
Pubmed

Rhombomere-specific analysis reveals the repertoire of genetic cues expressed across the developing hindbrain.

NR2F6 TNS1

1.68e-032778219208226
Pubmed

Conditionals by inversion provide a universal method for the generation of conditional alleles.

EXOSC10 CHRD

1.68e-032778223918385
Pubmed

Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord.

SEC24C BAZ2A

1.68e-032778219026994
Pubmed

The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.

RALGAPA1 KMT2D TONSL

1.77e-0310678331024071
Pubmed

High glucose mediates the ChREBP/p300 transcriptional complex to activate proapoptotic genes Puma and BAX and contributes to intervertebral disc degeneration.

FASN RETSAT

1.94e-032978234461288
Pubmed

WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.

BRD2 SEC24C TONSL RACGAP1 DCTN1

1.95e-0339478527248496
Pubmed

c-Jun is required for the specification of joint cell fates.

JUN CHRD

2.21e-033178223475960
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

JUN FASN EXOSC10 FAM120A FAM120C SRSF11 ELAC2

2.24e-0380778722681889
InteractionTOP3B interactions

JUN NR2F6 FASN KMT2D FAM120A BRD2 MAP1S NUAK1 FAM120C OBSCN PSMB10 RAP1GAP2 RACGAP1 MAPKBP1 IL17RD DCTN1 ELAC2 CRAMP1 WNK2

1.53e-0614707619int:TOP3B
Cytoband18p11.22

PPP4R1 NDUFV2

3.81e-041778218p11.22
Cytoband20q13.32

ZNF831 NPEPL1

5.31e-042078220q13.32
Cytoband2p13

RAB11FIP5 DCTN1

7.04e-04237822p13
Cytoband9q22.31

FAM120A FAM120AOS

9.73e-04277829q22.31
Cytoband12q13.12

KMT2D RACGAP1

1.93e-033878212q13.12
Diseasebrain measurement, neuroimaging measurement

ADAMTS19 MAST4 MCTP1 NUAK1 RREB1 TNS1 ELAC2 WNK2

7.09e-05550748EFO_0004346, EFO_0004464
Disease22q11 partial monosomy syndrome

SEC24C RREB1

2.21e-049742C3266101
DiseaseAsymmetric crying face association

SEC24C RREB1

2.76e-0410742C0431406
Disease22q11 Deletion Syndrome

SEC24C RREB1

2.76e-0410742C2936346
Diseaseargininosuccinate measurement

ABCC4 MC3R

3.36e-0411742EFO_0010461
Diseaseattention function measurement

NUAK1 LZTS1 ZNF831 ITPR1

5.32e-04148744EFO_0007636
DiseaseDiGeorge Syndrome

SEC24C RREB1

7.28e-0416742C0012236
DiseaseCONOTRUNCAL ANOMALY FACE SYNDROME

SEC24C RREB1

7.28e-0416742C0795907
DiseaseShprintzen syndrome

SEC24C RREB1

7.28e-0416742C0220704
Diseasecyclic adenosine monophosphate measurement

ABCC4 MAST4

8.24e-0417742EFO_0010473
DiseaseProstatic Neoplasms

ABCC4 KMT2D BAZ2A LZTS1 IL17RD ELAC2 ITPR1

8.97e-04616747C0033578
DiseaseMalignant neoplasm of prostate

ABCC4 KMT2D BAZ2A LZTS1 IL17RD ELAC2 ITPR1

8.97e-04616747C0376358
DiseaseMalignant neoplasm of breast

ADAMTS19 JUN NR2F6 FASN KMT2D CYP2D6 TRMT2A OBSCN TNS1

1.44e-031074749C0006142
Diseasecortical surface area measurement

ADAMTS19 MAST4 NUAK1 RREB1 OLIG1 IL17RD RETSAT TNS1 ELAC2 WNK2

1.89e-0313457410EFO_0010736
Diseaseplatelet-to-lymphocyte ratio

ABCC4 BAZ2A RAP1GAP2 RREB1 ZNF831

2.21e-03363745EFO_0008446

Protein segments in the cluster

PeptideGeneStartEntry
QLSGHLLKPRAPLEA

LINC01590

61

Q5TEZ4
ASLASLPPLHVAKLS

DCTN1

1121

Q14203
TPPDAHVLGKALEAA

CIITA

841

P33076
VRLLKAALHDPGFPS

BAZ2A

901

Q9UIF9
ALPLHTAPLLAAAGL

NR2F6

251

P10588
LSAQAKVLAPGASHP

RAB11FIP5

406

Q9BXF6
AKGPTTAPLHLLVLL

ADAMTS19

871

Q8TE59
LLAHPGPLLKSGETV

KIR3DL2

126

P43630
GTLRPAASLPHIAKT

KIAA0895L

111

Q68EN5
AHLRQKAGLPPDATI

C22orf15

26

Q8WYQ4
EKSAHLLSPILAGPS

ENTHD1

431

Q8IYW4
AALQPLLHTVKAGSP

IL17RD

641

Q8NFM7
REHLLPAVKGPAAAS

MCTP1

126

Q6DN14
LLDPASHKLLVLAGP

MAP1S

106

Q66K74
AFKPVLPRSGAILHS

LZTS1

126

Q9Y250
LISLAIVIALPKPHG

ITPR1

2326

Q14643
ALAPIATVKHAKSPG

LIPM

211

Q5VYY2
NLADPVGSLKPHLRA

JUN

41

P05412
PRPGVHLSADKALLQ

HMCN2

2121

Q8NDA2
VAAILQTHLPGKRPA

KDM8

141

Q8N371
HLPAAASASPKLTGL

MICALL2

241

Q8IY33
VGKAALHPPALAVLS

NPEPL1

231

Q8NDH3
LESAKGAPSIHLLPD

COL25A1

66

Q9BXS0
EKQSPVPILHGAAAL

MPP7

61

Q5T2T1
HLAAPKLGVALGPSL

AP5B1

621

Q2VPB7
ADIFHLANLTGLPPK

ASIC4

131

Q96FT7
SLLGPEHPLASLKVR

FAM120A

256

Q9NZB2
LVNLLHPAKPISFAG

OR2A7

81

Q96R45
LLVLVKDHGEPPLTA

PCDHA5

646

Q9Y5H7
KFPHLVPASLGLAAV

OLIG1

251

Q8TAK6
LVNLLHPAKPISFAG

OR2A4

81

O95047
LEFPGTVHLAPKLAV

OBSCN

601

Q5VST9
SPGGPLVLKHLTALI

ABCC4

1051

O15439
SPLILGDPLHKQAAL

DUOXA2

296

Q1HG44
LPSLGHRAPVSQAAK

EXOSC10

696

Q01780
LLVANAIKASLPHGP

FAM126A

276

Q9BYI3
GSLLPVAQAHKARPS

DACT2

156

Q5SW24
IIHGLLPAASVAPKA

CEP89

16

Q96ST8
AVPVLLHIPALAGKV

CYP2D6

226

P10635
IFPAHLQKPTLAIIG

FMO1

356

Q01740
AKDAHVLPPAQILGI

CRAMP1

436

Q96RY5
SLLGPEHPLASLKVR

FAM120C

331

Q9NX05
LHVKRIAALPPADGV

MC3R

216

P41968
APPLGSLLKDALHKQ

MAST4

1596

O15021
AHAPIRVSPLSKLAL

MAPKBP1

1276

O60336
LALHPKKPLAVTGSD

EML6

331

Q6ZMW3
PPALAGKLAASVHQA

DCLRE1A

411

Q6PJP8
HPEPASGLAALAKVL

FASN

331

P49327
LFHTSLPIAEAPGKL

SEC24C

641

P53992
PHLVAGALAASAPVL

DPP7

176

Q9UHL4
LSASAPLVIHFLKAP

CDH16

646

O75309
LANLLHPAKPISFAG

OR2A1;

81

Q8NGT9
LVNLLHPAKPISFAG

OR2A25

81

A4D2G3
VSSGAPHAILLKFLP

RETSAT

201

Q6NUM9
VAILDPPRAGLHSKV

TRMT2A

506

Q8IZ69
HERIPLAGLSKLPSV

RAP1GAP2

206

Q684P5
KLHAATPPTFGVDLI

PPP4R1

811

Q8TF05
KPPHLAALILARGGS

CMAS

41

Q8NFW8
SLHAHGLAKEAPILP

FAM120AOS

211

Q5T036
FSHLPVKGVLDQLPA

SLITRK2

506

Q9H156
AVAGATAALEPRKPH

NUAK1

26

O60285
ASLERVLPGLKVPHA

PSMB10

21

P40306
LAKVFGPTIVAHAVP

RACGAP1

496

Q9H0H5
PKAPAATSILHKAGE

MRTFA

391

Q969V6
APKRVSLALQLPEHG

SNED1

1286

Q8TER0
LKSLHSAGPPLLAVT

BRD2

251

P25440
ALVLPPVKSQAAGHA

CHRD

541

Q9H2X0
VAAGLPPILVHTDAA

SCLY

221

Q96I15
PPILVHTDAAQALGK

SCLY

226

Q96I15
ALPLKTLLQPFHATG

RALGAPA1

1401

Q6GYQ0
LASLGKPLHPLLVVA

ELAC2

566

Q9BQ52
PKLNHVAAGLVSPSL

SRSF11

196

Q05519
LLGLQHTKDVRPAPA

RREB1

366

Q92766
PRGHSKALAPQAALI

TONSL

811

Q96HA7
SALGLKPHNPADILL

TNS1

981

Q9HBL0
IHLGKAAKPSLPALD

TSHZ3

731

Q63HK5
LKAHEAARVLPPGLS

ZIM2

431

Q9NZV7
AALKVLGKDHLPSSP

nan

171

A8MV72
AALKVLGEDHLPSSP

nan

201

Q8N9G6
AALKVLGKDHLPSSP

nan

201

A8MUI8
AALKVLGKDHLPSSP

nan

201

A8MUA0
GKVLLFSLPHPEALL

GTF3C2

506

Q8WUA4
LLAVAPPGVAALSIH

WNK2

886

Q9Y3S1
LSPGAHVPLLAKNLD

ZNF831

246

Q5JPB2
AALPAGPAGELHAKV

KMT2D

2496

O14686
PEGHKAAAVLPVLDL

NDUFV2

71

P19404